Q96KT7 (S35G5_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Solute carrier family 35 member G5

Alternative name(s):
Acyl-malonyl-condensing enzyme 1-like protein 2

Gene names

Name:	SLC35G5
Synonyms:	AMAC, AMAC1L2

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	338 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subcellular location	Membrane; Multi-pass membrane protein Potential.
Tissue specificity	Expressed in placenta and testis. Ref.3
Miscellaneous	The gene encoding this protein appears to have arisen by SVA-mediated retrotransposition of the SLC35G6 gene in the primate lineage.
Sequence similarities	Belongs to the SLC35G solute transporter family. Contains 2 EamA domains.

Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Polymorphism
Domain	Repeat Transmembrane Transmembrane helix
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 338	338	Solute carrier family 35 member G5		PRO_0000269556
Regions
	Transmembrane	37 – 57	21	Helical; Potential
	Transmembrane	67 – 87	21	Helical; Potential
	Transmembrane	102 – 122	21	Helical; Potential
	Transmembrane	160 – 180	21	Helical; Potential
	Transmembrane	190 – 210	21	Helical; Potential
	Transmembrane	221 – 241	21	Helical; Potential
	Transmembrane	250 – 270	21	Helical; Potential
	Transmembrane	281 – 301	21	Helical; Potential
	Transmembrane	305 – 325	21	Helical; Potential
	Domain	49 – 174	126	EamA 1
	Domain	272 – 325	54	EamA 2
Natural variations
	Natural variant	46	1	G → D. Corresponds to variant rs6990563 [ dbSNP | Ensembl ].		VAR_059579
	Natural variant	307	1	L → P. Corresponds to variant rs12681991 [ dbSNP | Ensembl ].		VAR_059580

Sequences

	Sequence		Length	Mass (Da)
	Q96KT7 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: 8421C9A5E1E48D35	FASTA	338	35,161
	10 20 30 40 50 60 MAGSHPYFNL PDSTHPSPPS APPSLRWHQR CQPSGATNGL LVALLGGGLP AGFVGPLSRM 70 80 90 100 110 120 AYQGSNLPSL ELLICRCLFH LPIALLLKLR GDPLLGPPDI RGWACFCALL NVLSIGCAYS 130 140 150 160 170 180 AVQVVPAGNA ATVRKGSSTV CSAVLTLCLE SQGLGGYEWC GLLGSILGLI IILGPGLWTL 190 200 210 220 230 240 QEGTTGVYTT LGYVQAFLGG LALSLGLLVY RSLHFPSCLP TVAFLSGLVG LLGCVPGLFV 250 260 270 280 290 300 LQTPVLPSDL LSWSCVGAEG ILALVSFTCV GYAVTKAHPA LVCAVLHSEV VVALILQYYM 310 320 330 LHETVALSDI MGAGVVLGSI AIITARNLSC ERTGKVEE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Physical and transcriptional map of the critical region for keratolytic winter erythema (KWE) on chromosome 8p22-p23 between D8S550 and D8S1759." Appel S., Filter M., Reis A., Hennies H.C., Bergheim A., Ogilvie E., Arndt S., Simmons A., Lovett M., Hide W., Ramsay M., Reichwald K., Zimmermann W., Rosenthal A. Eur. J. Hum. Genet. 10:17-25(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]	"Emergence of primate genes by retrotransposon-mediated sequence transduction." Xing J., Wang H., Belancio V.P., Cordaux R., Deininger P.L., Batzer M.A. Proc. Natl. Acad. Sci. U.S.A. 103:17608-17613(2006) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY, GENE EVOLUTION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ291677 mRNA. Translation: CAC82744.1. BC131696 mRNA. Translation: AAI31697.1.
IPI	IPI00064799.
RefSeq	NP_473369.1. NM_054028.1.
UniGene	Hs.458397.
3D structure databases
ProteinModelPortal	Q96KT7.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000371872.
Polymorphism databases
DMDM	74751987.
Proteomic databases
PRIDE	Q96KT7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000382435; ENSP00000371872; ENSG00000177710.
GeneID	83650.
KEGG	hsa:83650.
UCSC	uc003wtp.1. human.
Organism-specific databases
CTD	83650.
GeneCards	GC08P011189.
HGNC	HGNC:15546. SLC35G5.
neXtProt	NX_Q96KT7.
PharmGKB	PA24756.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	HOG000033917.
HOVERGEN	HBG080671.
InParanoid	Q96KT7.
OMA	EVVVALM.
OrthoDB	EOG4K0QPB.
PhylomeDB	Q96KT7.
Gene expression databases
Bgee	Q96KT7.
CleanEx	HS_AMAC1L2.
Genevestigator	Q96KT7.
Family and domain databases
InterPro	IPR000620. DMT. [Graphical view]
Pfam	PF00892. EamA. 2 hits. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	83650.
NextBio	72611.

Entry information

Entry name

S35G5_HUMAN

Accession

Primary (citable) accession number: Q96KT7
Secondary accession number(s): A2RRL6

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 12, 2006
Last sequence update:	December 1, 2001
Last modified:	April 3, 2013
This is version 67 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.