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Protein

Solute carrier family 35 member G5

Gene

SLC35G5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Enzyme and pathway databases

BioCyciZFISH:ENSG00000164729-MONOMER.

Protein family/group databases

TCDBi2.A.7.28.5. the drug/metabolite transporter (dmt) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 35 member G5
Alternative name(s):
Acyl-malonyl-condensing enzyme 1-like protein 2
Gene namesi
Name:SLC35G5
Synonyms:AMAC, AMAC1L2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:15546. SLC35G5.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei37 – 57HelicalSequence analysisAdd BLAST21
Transmembranei67 – 87HelicalSequence analysisAdd BLAST21
Transmembranei102 – 122HelicalSequence analysisAdd BLAST21
Transmembranei160 – 180HelicalSequence analysisAdd BLAST21
Transmembranei190 – 210HelicalSequence analysisAdd BLAST21
Transmembranei221 – 241HelicalSequence analysisAdd BLAST21
Transmembranei250 – 270HelicalSequence analysisAdd BLAST21
Transmembranei281 – 301HelicalSequence analysisAdd BLAST21
Transmembranei305 – 325HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi83650.
OpenTargetsiENSG00000177710.
PharmGKBiPA24756.

Polymorphism and mutation databases

BioMutaiSLC35G5.
DMDMi74751987.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002695561 – 338Solute carrier family 35 member G5Add BLAST338

Proteomic databases

PaxDbiQ96KT7.
PRIDEiQ96KT7.

PTM databases

iPTMnetiQ96KT7.
PhosphoSitePlusiQ96KT7.

Expressioni

Tissue specificityi

Expressed in placenta and testis.1 Publication

Gene expression databases

BgeeiENSG00000177710.
CleanExiHS_AMAC1L2.
GenevisibleiQ96KT7. HS.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000371872.

Structurei

3D structure databases

ProteinModelPortaliQ96KT7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini49 – 174EamA 1Add BLAST126
Domaini272 – 325EamA 2Add BLAST54

Sequence similaritiesi

Belongs to the SLC35G solute transporter family.Curated
Contains 2 EamA domains.Curated

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IEWA. Eukaryota.
ENOG410YABU. LUCA.
GeneTreeiENSGT00730000110996.
HOGENOMiHOG000033917.
HOVERGENiHBG080671.
InParanoidiQ96KT7.
OrthoDBiEOG091G070D.
PhylomeDBiQ96KT7.
TreeFamiTF331838.

Sequencei

Sequence statusi: Complete.

Q96KT7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGSHPYFNL PDSTHPSPPS APPSLRWHQR CQPSGATNGL LVALLGGGLP
60 70 80 90 100
AGFVGPLSRM AYQGSNLPSL ELLICRCLFH LPIALLLKLR GDPLLGPPDI
110 120 130 140 150
RGWACFCALL NVLSIGCAYS AVQVVPAGNA ATVRKGSSTV CSAVLTLCLE
160 170 180 190 200
SQGLGGYEWC GLLGSILGLI IILGPGLWTL QEGTTGVYTT LGYVQAFLGG
210 220 230 240 250
LALSLGLLVY RSLHFPSCLP TVAFLSGLVG LLGCVPGLFV LQTPVLPSDL
260 270 280 290 300
LSWSCVGAEG ILALVSFTCV GYAVTKAHPA LVCAVLHSEV VVALILQYYM
310 320 330
LHETVALSDI MGAGVVLGSI AIITARNLSC ERTGKVEE
Length:338
Mass (Da):35,161
Last modified:December 1, 2001 - v1
Checksum:i8421C9A5E1E48D35
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05957946G → D.Corresponds to variant rs6990563dbSNPEnsembl.1
Natural variantiVAR_059580307L → P.Corresponds to variant rs12681991dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ291677 mRNA. Translation: CAC82744.1.
BC131696 mRNA. Translation: AAI31697.1.
CCDSiCCDS5980.1.
RefSeqiNP_473369.1. NM_054028.1.
UniGeneiHs.458397.

Genome annotation databases

EnsembliENST00000382435; ENSP00000371872; ENSG00000177710.
GeneIDi83650.
KEGGihsa:83650.
UCSCiuc003wtp.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ291677 mRNA. Translation: CAC82744.1.
BC131696 mRNA. Translation: AAI31697.1.
CCDSiCCDS5980.1.
RefSeqiNP_473369.1. NM_054028.1.
UniGeneiHs.458397.

3D structure databases

ProteinModelPortaliQ96KT7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000371872.

Protein family/group databases

TCDBi2.A.7.28.5. the drug/metabolite transporter (dmt) superfamily.

PTM databases

iPTMnetiQ96KT7.
PhosphoSitePlusiQ96KT7.

Polymorphism and mutation databases

BioMutaiSLC35G5.
DMDMi74751987.

Proteomic databases

PaxDbiQ96KT7.
PRIDEiQ96KT7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000382435; ENSP00000371872; ENSG00000177710.
GeneIDi83650.
KEGGihsa:83650.
UCSCiuc003wtp.2. human.

Organism-specific databases

CTDi83650.
DisGeNETi83650.
GeneCardsiSLC35G5.
HGNCiHGNC:15546. SLC35G5.
MIMi615199. gene.
neXtProtiNX_Q96KT7.
OpenTargetsiENSG00000177710.
PharmGKBiPA24756.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IEWA. Eukaryota.
ENOG410YABU. LUCA.
GeneTreeiENSGT00730000110996.
HOGENOMiHOG000033917.
HOVERGENiHBG080671.
InParanoidiQ96KT7.
OrthoDBiEOG091G070D.
PhylomeDBiQ96KT7.
TreeFamiTF331838.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000164729-MONOMER.

Miscellaneous databases

GenomeRNAii83650.
PROiQ96KT7.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000177710.
CleanExiHS_AMAC1L2.
GenevisibleiQ96KT7. HS.

Family and domain databases

ProtoNetiSearch...

Entry informationi

Entry nameiS35G5_HUMAN
AccessioniPrimary (citable) accession number: Q96KT7
Secondary accession number(s): A2RRL6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: December 1, 2001
Last modified: November 2, 2016
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

The gene encoding this protein appears to have arisen by SVA-mediated retrotransposition of the SLC35G6 gene in the primate lineage.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.