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Q96KT7

- S35G5_HUMAN

UniProt

Q96KT7 - S35G5_HUMAN

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Protein

Solute carrier family 35 member G5

Gene

SLC35G5

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

Protein family/group databases

TCDBi2.A.7.28.5. the drug/metabolite transporter (dmt) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 35 member G5
Alternative name(s):
Acyl-malonyl-condensing enzyme 1-like protein 2
Gene namesi
Name:SLC35G5
Synonyms:AMAC, AMAC1L2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 8

Organism-specific databases

HGNCiHGNC:15546. SLC35G5.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA24756.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 338338Solute carrier family 35 member G5PRO_0000269556Add
BLAST

Proteomic databases

PRIDEiQ96KT7.

Expressioni

Tissue specificityi

Expressed in placenta and testis.1 Publication

Gene expression databases

BgeeiQ96KT7.
CleanExiHS_AMAC1L2.
GenevestigatoriQ96KT7.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000371872.

Structurei

3D structure databases

ProteinModelPortaliQ96KT7.
ModBaseiSearch...
MobiDBiSearch...

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei37 – 5721HelicalSequence AnalysisAdd
BLAST
Transmembranei67 – 8721HelicalSequence AnalysisAdd
BLAST
Transmembranei102 – 12221HelicalSequence AnalysisAdd
BLAST
Transmembranei160 – 18021HelicalSequence AnalysisAdd
BLAST
Transmembranei190 – 21021HelicalSequence AnalysisAdd
BLAST
Transmembranei221 – 24121HelicalSequence AnalysisAdd
BLAST
Transmembranei250 – 27021HelicalSequence AnalysisAdd
BLAST
Transmembranei281 – 30121HelicalSequence AnalysisAdd
BLAST
Transmembranei305 – 32521HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini49 – 174126EamA 1Add
BLAST
Domaini272 – 32554EamA 2Add
BLAST

Sequence similaritiesi

Belongs to the SLC35G solute transporter family.Curated
Contains 2 EamA domains.Curated

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00730000110996.
HOGENOMiHOG000033917.
HOVERGENiHBG080671.
InParanoidiQ96KT7.
OrthoDBiEOG7BGHKM.
PhylomeDBiQ96KT7.
TreeFamiTF331838.

Family and domain databases

InterProiIPR000620. DMT.
[Graphical view]
PfamiPF00892. EamA. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96KT7 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAGSHPYFNL PDSTHPSPPS APPSLRWHQR CQPSGATNGL LVALLGGGLP
60 70 80 90 100
AGFVGPLSRM AYQGSNLPSL ELLICRCLFH LPIALLLKLR GDPLLGPPDI
110 120 130 140 150
RGWACFCALL NVLSIGCAYS AVQVVPAGNA ATVRKGSSTV CSAVLTLCLE
160 170 180 190 200
SQGLGGYEWC GLLGSILGLI IILGPGLWTL QEGTTGVYTT LGYVQAFLGG
210 220 230 240 250
LALSLGLLVY RSLHFPSCLP TVAFLSGLVG LLGCVPGLFV LQTPVLPSDL
260 270 280 290 300
LSWSCVGAEG ILALVSFTCV GYAVTKAHPA LVCAVLHSEV VVALILQYYM
310 320 330
LHETVALSDI MGAGVVLGSI AIITARNLSC ERTGKVEE
Length:338
Mass (Da):35,161
Last modified:December 1, 2001 - v1
Checksum:i8421C9A5E1E48D35
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti46 – 461G → D.
Corresponds to variant rs6990563 [ dbSNP | Ensembl ].
VAR_059579
Natural varianti307 – 3071L → P.
Corresponds to variant rs12681991 [ dbSNP | Ensembl ].
VAR_059580

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ291677 mRNA. Translation: CAC82744.1.
BC131696 mRNA. Translation: AAI31697.1.
CCDSiCCDS5980.1.
RefSeqiNP_473369.1. NM_054028.1.
UniGeneiHs.458397.

Genome annotation databases

EnsembliENST00000382435; ENSP00000371872; ENSG00000177710.
GeneIDi83650.
KEGGihsa:83650.
UCSCiuc003wtp.1. human.

Polymorphism databases

DMDMi74751987.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ291677 mRNA. Translation: CAC82744.1 .
BC131696 mRNA. Translation: AAI31697.1 .
CCDSi CCDS5980.1.
RefSeqi NP_473369.1. NM_054028.1.
UniGenei Hs.458397.

3D structure databases

ProteinModelPortali Q96KT7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000371872.

Protein family/group databases

TCDBi 2.A.7.28.5. the drug/metabolite transporter (dmt) superfamily.

Polymorphism databases

DMDMi 74751987.

Proteomic databases

PRIDEi Q96KT7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000382435 ; ENSP00000371872 ; ENSG00000177710 .
GeneIDi 83650.
KEGGi hsa:83650.
UCSCi uc003wtp.1. human.

Organism-specific databases

CTDi 83650.
GeneCardsi GC08P011189.
HGNCi HGNC:15546. SLC35G5.
MIMi 615199. gene.
neXtProti NX_Q96KT7.
PharmGKBi PA24756.
GenAtlasi Search...

Phylogenomic databases

GeneTreei ENSGT00730000110996.
HOGENOMi HOG000033917.
HOVERGENi HBG080671.
InParanoidi Q96KT7.
OrthoDBi EOG7BGHKM.
PhylomeDBi Q96KT7.
TreeFami TF331838.

Miscellaneous databases

GenomeRNAii 83650.
NextBioi 72611.
PROi Q96KT7.
SOURCEi Search...

Gene expression databases

Bgeei Q96KT7.
CleanExi HS_AMAC1L2.
Genevestigatori Q96KT7.

Family and domain databases

InterProi IPR000620. DMT.
[Graphical view ]
Pfami PF00892. EamA. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Physical and transcriptional map of the critical region for keratolytic winter erythema (KWE) on chromosome 8p22-p23 between D8S550 and D8S1759."
    Appel S., Filter M., Reis A., Hennies H.C., Bergheim A., Ogilvie E., Arndt S., Simmons A., Lovett M., Hide W., Ramsay M., Reichwald K., Zimmermann W., Rosenthal A.
    Eur. J. Hum. Genet. 10:17-25(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "Emergence of primate genes by retrotransposon-mediated sequence transduction."
    Xing J., Wang H., Belancio V.P., Cordaux R., Deininger P.L., Batzer M.A.
    Proc. Natl. Acad. Sci. U.S.A. 103:17608-17613(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, GENE EVOLUTION.

Entry informationi

Entry nameiS35G5_HUMAN
AccessioniPrimary (citable) accession number: Q96KT7
Secondary accession number(s): A2RRL6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: December 1, 2001
Last modified: October 29, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

The gene encoding this protein appears to have arisen by SVA-mediated retrotransposition of the SLC35G6 gene in the primate lineage.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3