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Q96KT7

- S35G5_HUMAN

UniProt

Q96KT7 - S35G5_HUMAN

Protein

Solute carrier family 35 member G5

Gene

SLC35G5

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 75 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    Protein family/group databases

    TCDBi2.A.7.28.5. the drug/metabolite transporter (dmt) superfamily.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Solute carrier family 35 member G5
    Alternative name(s):
    Acyl-malonyl-condensing enzyme 1-like protein 2
    Gene namesi
    Name:SLC35G5
    Synonyms:AMAC, AMAC1L2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 8

    Organism-specific databases

    HGNCiHGNC:15546. SLC35G5.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA24756.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 338338Solute carrier family 35 member G5PRO_0000269556Add
    BLAST

    Proteomic databases

    PRIDEiQ96KT7.

    Expressioni

    Tissue specificityi

    Expressed in placenta and testis.1 Publication

    Gene expression databases

    BgeeiQ96KT7.
    CleanExiHS_AMAC1L2.
    GenevestigatoriQ96KT7.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000371872.

    Structurei

    3D structure databases

    ProteinModelPortaliQ96KT7.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei37 – 5721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei67 – 8721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei102 – 12221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei160 – 18021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei190 – 21021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei221 – 24121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei250 – 27021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei281 – 30121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei305 – 32521HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini49 – 174126EamA 1Add
    BLAST
    Domaini272 – 32554EamA 2Add
    BLAST

    Sequence similaritiesi

    Belongs to the SLC35G solute transporter family.Curated
    Contains 2 EamA domains.Curated

    Keywords - Domaini

    Repeat, Transmembrane, Transmembrane helix

    Phylogenomic databases

    HOGENOMiHOG000033917.
    HOVERGENiHBG080671.
    InParanoidiQ96KT7.
    OrthoDBiEOG7BGHKM.
    PhylomeDBiQ96KT7.
    TreeFamiTF331838.

    Family and domain databases

    InterProiIPR000620. DMT.
    [Graphical view]
    PfamiPF00892. EamA. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q96KT7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAGSHPYFNL PDSTHPSPPS APPSLRWHQR CQPSGATNGL LVALLGGGLP    50
    AGFVGPLSRM AYQGSNLPSL ELLICRCLFH LPIALLLKLR GDPLLGPPDI 100
    RGWACFCALL NVLSIGCAYS AVQVVPAGNA ATVRKGSSTV CSAVLTLCLE 150
    SQGLGGYEWC GLLGSILGLI IILGPGLWTL QEGTTGVYTT LGYVQAFLGG 200
    LALSLGLLVY RSLHFPSCLP TVAFLSGLVG LLGCVPGLFV LQTPVLPSDL 250
    LSWSCVGAEG ILALVSFTCV GYAVTKAHPA LVCAVLHSEV VVALILQYYM 300
    LHETVALSDI MGAGVVLGSI AIITARNLSC ERTGKVEE 338
    Length:338
    Mass (Da):35,161
    Last modified:December 1, 2001 - v1
    Checksum:i8421C9A5E1E48D35
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti46 – 461G → D.
    Corresponds to variant rs6990563 [ dbSNP | Ensembl ].
    VAR_059579
    Natural varianti307 – 3071L → P.
    Corresponds to variant rs12681991 [ dbSNP | Ensembl ].
    VAR_059580

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ291677 mRNA. Translation: CAC82744.1.
    BC131696 mRNA. Translation: AAI31697.1.
    CCDSiCCDS5980.1.
    RefSeqiNP_473369.1. NM_054028.1.
    UniGeneiHs.458397.

    Genome annotation databases

    EnsembliENST00000382435; ENSP00000371872; ENSG00000177710.
    GeneIDi83650.
    KEGGihsa:83650.
    UCSCiuc003wtp.1. human.

    Polymorphism databases

    DMDMi74751987.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ291677 mRNA. Translation: CAC82744.1 .
    BC131696 mRNA. Translation: AAI31697.1 .
    CCDSi CCDS5980.1.
    RefSeqi NP_473369.1. NM_054028.1.
    UniGenei Hs.458397.

    3D structure databases

    ProteinModelPortali Q96KT7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000371872.

    Protein family/group databases

    TCDBi 2.A.7.28.5. the drug/metabolite transporter (dmt) superfamily.

    Polymorphism databases

    DMDMi 74751987.

    Proteomic databases

    PRIDEi Q96KT7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000382435 ; ENSP00000371872 ; ENSG00000177710 .
    GeneIDi 83650.
    KEGGi hsa:83650.
    UCSCi uc003wtp.1. human.

    Organism-specific databases

    CTDi 83650.
    GeneCardsi GC08P011189.
    HGNCi HGNC:15546. SLC35G5.
    MIMi 615199. gene.
    neXtProti NX_Q96KT7.
    PharmGKBi PA24756.
    GenAtlasi Search...

    Phylogenomic databases

    HOGENOMi HOG000033917.
    HOVERGENi HBG080671.
    InParanoidi Q96KT7.
    OrthoDBi EOG7BGHKM.
    PhylomeDBi Q96KT7.
    TreeFami TF331838.

    Miscellaneous databases

    GenomeRNAii 83650.
    NextBioi 72611.
    PROi Q96KT7.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q96KT7.
    CleanExi HS_AMAC1L2.
    Genevestigatori Q96KT7.

    Family and domain databases

    InterProi IPR000620. DMT.
    [Graphical view ]
    Pfami PF00892. EamA. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Physical and transcriptional map of the critical region for keratolytic winter erythema (KWE) on chromosome 8p22-p23 between D8S550 and D8S1759."
      Appel S., Filter M., Reis A., Hennies H.C., Bergheim A., Ogilvie E., Arndt S., Simmons A., Lovett M., Hide W., Ramsay M., Reichwald K., Zimmermann W., Rosenthal A.
      Eur. J. Hum. Genet. 10:17-25(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    3. "Emergence of primate genes by retrotransposon-mediated sequence transduction."
      Xing J., Wang H., Belancio V.P., Cordaux R., Deininger P.L., Batzer M.A.
      Proc. Natl. Acad. Sci. U.S.A. 103:17608-17613(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY, GENE EVOLUTION.

    Entry informationi

    Entry nameiS35G5_HUMAN
    AccessioniPrimary (citable) accession number: Q96KT7
    Secondary accession number(s): A2RRL6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 12, 2006
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 75 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    The gene encoding this protein appears to have arisen by SVA-mediated retrotransposition of the SLC35G6 gene in the primate lineage.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 8
      Human chromosome 8: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3