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Q96KT7 (S35G5_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 73. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Solute carrier family 35 member G5
Alternative name(s):
Acyl-malonyl-condensing enzyme 1-like protein 2
Gene names
Name:SLC35G5
Synonyms:AMAC, AMAC1L2
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length338 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subcellular location

Membrane; Multi-pass membrane protein Potential.

Tissue specificity

Expressed in placenta and testis. Ref.3

Miscellaneous

The gene encoding this protein appears to have arisen by SVA-mediated retrotransposition of the SLC35G6 gene in the primate lineage.

Sequence similarities

Belongs to the SLC35G solute transporter family.

Contains 2 EamA domains.

Ontologies

Keywords
   Cellular componentMembrane
   Coding sequence diversityPolymorphism
   DomainRepeat
Transmembrane
Transmembrane helix
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 338338Solute carrier family 35 member G5
PRO_0000269556

Regions

Transmembrane37 – 5721Helical; Potential
Transmembrane67 – 8721Helical; Potential
Transmembrane102 – 12221Helical; Potential
Transmembrane160 – 18021Helical; Potential
Transmembrane190 – 21021Helical; Potential
Transmembrane221 – 24121Helical; Potential
Transmembrane250 – 27021Helical; Potential
Transmembrane281 – 30121Helical; Potential
Transmembrane305 – 32521Helical; Potential
Domain49 – 174126EamA 1
Domain272 – 32554EamA 2

Natural variations

Natural variant461G → D.
Corresponds to variant rs6990563 [ dbSNP | Ensembl ].
VAR_059579
Natural variant3071L → P.
Corresponds to variant rs12681991 [ dbSNP | Ensembl ].
VAR_059580

Sequences

Sequence LengthMass (Da)Tools
Q96KT7 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: 8421C9A5E1E48D35

FASTA33835,161
        10         20         30         40         50         60 
MAGSHPYFNL PDSTHPSPPS APPSLRWHQR CQPSGATNGL LVALLGGGLP AGFVGPLSRM 

        70         80         90        100        110        120 
AYQGSNLPSL ELLICRCLFH LPIALLLKLR GDPLLGPPDI RGWACFCALL NVLSIGCAYS 

       130        140        150        160        170        180 
AVQVVPAGNA ATVRKGSSTV CSAVLTLCLE SQGLGGYEWC GLLGSILGLI IILGPGLWTL 

       190        200        210        220        230        240 
QEGTTGVYTT LGYVQAFLGG LALSLGLLVY RSLHFPSCLP TVAFLSGLVG LLGCVPGLFV 

       250        260        270        280        290        300 
LQTPVLPSDL LSWSCVGAEG ILALVSFTCV GYAVTKAHPA LVCAVLHSEV VVALILQYYM 

       310        320        330 
LHETVALSDI MGAGVVLGSI AIITARNLSC ERTGKVEE 

« Hide

References

« Hide 'large scale' references
[1]"Physical and transcriptional map of the critical region for keratolytic winter erythema (KWE) on chromosome 8p22-p23 between D8S550 and D8S1759."
Appel S., Filter M., Reis A., Hennies H.C., Bergheim A., Ogilvie E., Arndt S., Simmons A., Lovett M., Hide W., Ramsay M., Reichwald K., Zimmermann W., Rosenthal A.
Eur. J. Hum. Genet. 10:17-25(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]"Emergence of primate genes by retrotransposon-mediated sequence transduction."
Xing J., Wang H., Belancio V.P., Cordaux R., Deininger P.L., Batzer M.A.
Proc. Natl. Acad. Sci. U.S.A. 103:17608-17613(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY, GENE EVOLUTION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ291677 mRNA. Translation: CAC82744.1.
BC131696 mRNA. Translation: AAI31697.1.
RefSeqNP_473369.1. NM_054028.1.
UniGeneHs.458397.

3D structure databases

ProteinModelPortalQ96KT7.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000371872.

Protein family/group databases

TCDB2.A.7.28.5. the drug/metabolite transporter (dmt) superfamily.

Polymorphism databases

DMDM74751987.

Proteomic databases

PRIDEQ96KT7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000382435; ENSP00000371872; ENSG00000177710.
GeneID83650.
KEGGhsa:83650.
UCSCuc003wtp.1. human.

Organism-specific databases

CTD83650.
GeneCardsGC08P011189.
HGNCHGNC:15546. SLC35G5.
MIM615199. gene.
neXtProtNX_Q96KT7.
PharmGKBPA24756.
GenAtlasSearch...

Phylogenomic databases

HOGENOMHOG000033917.
HOVERGENHBG080671.
InParanoidQ96KT7.
OrthoDBEOG7BGHKM.
PhylomeDBQ96KT7.
TreeFamTF331838.

Gene expression databases

BgeeQ96KT7.
CleanExHS_AMAC1L2.
GenevestigatorQ96KT7.

Family and domain databases

InterProIPR000620. DMT.
[Graphical view]
PfamPF00892. EamA. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi83650.
NextBio72611.
PROQ96KT7.
SOURCESearch...

Entry information

Entry nameS35G5_HUMAN
AccessionPrimary (citable) accession number: Q96KT7
Secondary accession number(s): A2RRL6
Entry history
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: December 1, 2001
Last modified: February 19, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 8

Human chromosome 8: entries, gene names and cross-references to MIM