Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Protein FAM210B, mitochondrial

Gene

FAM210B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a role in erythroid differentiation (PubMed:26968549). Involved in cell proliferation and tumor cell growth suppression (PubMed:28594398). Involved in the metabolic reprogramming of cancer cells in a PDK4-dependent manner (PubMed:28594398).2 Publications

GO - Biological processi

  • cellular response to estradiol stimulus Source: UniProtKB
  • erythrocyte maturation Source: UniProtKB-KW
  • positive regulation of erythrocyte differentiation Source: UniProtKB

Keywordsi

Biological processDifferentiation, Erythrocyte maturation

Names & Taxonomyi

Protein namesi
Recommended name:
Protein FAM210B, mitochondrialCurated
Gene namesi
Name:FAM210BImported
Synonyms:C20orf108
ORF Names:PSEC0265
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

EuPathDBiHostDB:ENSG00000124098.9
HGNCiHGNC:16102 FAM210B
neXtProtiNX_Q96KR6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei99 – 119HelicalSequence analysisAdd BLAST21
Transmembranei150 – 170HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion outer membrane

Pathology & Biotechi

Keywords - Diseasei

Tumor suppressor

Organism-specific databases

DisGeNETi116151
OpenTargetsiENSG00000124098
PharmGKBiPA25647

Polymorphism and mutation databases

BioMutaiFAM210B
DMDMi41688811

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 58MitochondrionSequence analysis1 PublicationAdd BLAST58
ChainiPRO_000007945159 – 192Protein FAM210B, mitochondrialAdd BLAST134

Proteomic databases

EPDiQ96KR6
MaxQBiQ96KR6
PaxDbiQ96KR6
PeptideAtlasiQ96KR6
PRIDEiQ96KR6
ProteomicsDBi77108
TopDownProteomicsiQ96KR6

PTM databases

iPTMnetiQ96KR6
PhosphoSitePlusiQ96KR6

Expressioni

Tissue specificityi

Expressed in late erythroblast differentiation stages (PubMed:26968549). Underexpressed in ovarian cancer epithelia cells compared with normal human ovarian surface epithelia (PubMed:28594398).2 Publications

Inductioni

Up-regulated by the erythroid transcription factor GATA1 (PubMed:26968549).1 Publication

Gene expression databases

BgeeiENSG00000124098
CleanExiHS_C20orf108
ExpressionAtlasiQ96KR6 baseline and differential
GenevisibleiQ96KR6 HS

Organism-specific databases

HPAiHPA042652

Interactioni

Protein-protein interaction databases

BioGridi125482, 14 interactors
STRINGi9606.ENSP00000360437

Structurei

3D structure databases

ProteinModelPortaliQ96KR6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini80 – 191DUF1279Add BLAST112

Sequence similaritiesi

Belongs to the FAM210 family.Curated

Keywords - Domaini

Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4526 Eukaryota
ENOG411243X LUCA
GeneTreeiENSGT00530000063556
HOGENOMiHOG000115712
HOVERGENiHBG051187
InParanoidiQ96KR6
OMAiDCRGRQD
OrthoDBiEOG091G11NI
PhylomeDBiQ96KR6
TreeFamiTF313283

Family and domain databases

InterProiView protein in InterPro
IPR009688 DUF1279
PfamiView protein in Pfam
PF06916 DUF1279, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q96KR6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGLLALLGP AGRVGARVRP RATWLLGATA PCAPPPLALA LLPPRLDARL
60 70 80 90 100
LRTARGDCRG HQDPSQATGT TGSSVSCTEE KKQSKSQQLK KIFQEYGTVG
110 120 130 140 150
VSLHIGISLI SLGIFYMVVS SGVDMPAILL KLGFKESLVQ SKMAAGTSTF
160 170 180 190
VVAYAIHKLF APVRISITLV SVPLIVRYFR KVGFFKPPAA KP
Length:192
Mass (Da):20,424
Last modified:October 10, 2003 - v2
Checksum:iFE895D3E5FB042D2
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti36P → L in CAC67490 (Ref. 1) Curated1
Sequence conflicti161A → V in AAH17725 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_033763126P → S. Corresponds to variant dbSNP:rs6099115Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ311123 mRNA Translation: CAC67490.1
AK075565 mRNA Translation: BAC11704.1
AK314768 mRNA Translation: BAG37306.1
AL121914 Genomic DNA No translation available.
CH471077 Genomic DNA Translation: EAW75564.1
CH471077 Genomic DNA Translation: EAW75565.1
BC017725 mRNA Translation: AAH17725.1
CCDSiCCDS13450.1
RefSeqiNP_543011.2, NM_080821.2
UniGeneiHs.143736

Genome annotation databases

EnsembliENST00000371384; ENSP00000360437; ENSG00000124098
GeneIDi116151
KEGGihsa:116151
UCSCiuc002xxc.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiF210B_HUMAN
AccessioniPrimary (citable) accession number: Q96KR6
Secondary accession number(s): B2RBQ9
, E1P5Y7, Q8WVN2, Q9BYL6, Q9H418
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 10, 2003
Last modified: June 20, 2018
This is version 119 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health