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Protein

Apoptosis-stimulating of p53 protein 1

Gene

PPP1R13B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Regulator that plays a central role in regulation of apoptosis via its interaction with p53/TP53. Regulates TP53 by enhancing the DNA binding and transactivation function of TP53 on the promoters of proapoptotic genes in vivo.1 Publication

GO - Biological processi

  1. intrinsic apoptotic signaling pathway by p53 class mediator Source: UniProtKB
  2. negative regulation of cell cycle Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Apoptosis

Names & Taxonomyi

Protein namesi
Recommended name:
Apoptosis-stimulating of p53 protein 1
Alternative name(s):
Protein phosphatase 1 regulatory subunit 13B
Gene namesi
Name:PPP1R13B
Synonyms:ASPP1, KIAA0771
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 14

Organism-specific databases

HGNCiHGNC:14950. PPP1R13B.

Subcellular locationi

Cytoplasm 1 Publication. Nucleus 1 Publication
Note: Predominantly cytoplasmic. Some fraction is nuclear.

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. nucleoplasm Source: HPA
  3. nucleus Source: UniProtKB
  4. plasma membrane Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA33622.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10901090Apoptosis-stimulating of p53 protein 1PRO_0000066962Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei332 – 3321Phosphoserine1 Publication
Modified residuei335 – 3351Phosphoserine1 Publication
Modified residuei681 – 6811Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ96KQ4.
PaxDbiQ96KQ4.
PRIDEiQ96KQ4.

PTM databases

PhosphoSiteiQ96KQ4.

Expressioni

Tissue specificityi

Reduced expression in breast carcinomas expressing a wild-type TP53 protein.1 Publication

Gene expression databases

BgeeiQ96KQ4.
CleanExiHS_PPP1R13B.
ExpressionAtlasiQ96KQ4. baseline and differential.
GenevestigatoriQ96KQ4.

Organism-specific databases

HPAiCAB015454.
HPA006394.

Interactioni

Subunit structurei

Interacts with TP53.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
EP300Q094722EBI-1105153,EBI-447295
PPP1CAP621365EBI-1105153,EBI-357253

Protein-protein interaction databases

BioGridi116948. 21 interactions.
IntActiQ96KQ4. 22 interactions.
MINTiMINT-1130841.
STRINGi9606.ENSP00000202556.

Structurei

3D structure databases

ProteinModelPortaliQ96KQ4.
SMRiQ96KQ4. Positions 1-83, 887-1083.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati920 – 95233ANK 1Add
BLAST
Repeati953 – 98533ANK 2Add
BLAST
Domaini1019 – 108163SH3PROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi132 – 292161Gln-richAdd
BLAST
Compositional biasi428 – 860433Pro-richAdd
BLAST

Domaini

The ankyrin repeats and the SH3 domain are required for specific interactions with TP53.

Sequence similaritiesi

Belongs to the ASPP family.Curated
Contains 2 ANK repeats.PROSITE-ProRule annotation
Contains 1 SH3 domain.PROSITE-ProRule annotation

Keywords - Domaini

ANK repeat, Repeat, SH3 domain

Phylogenomic databases

eggNOGiNOG283717.
GeneTreeiENSGT00760000119141.
HOGENOMiHOG000034106.
HOVERGENiHBG050596.
InParanoidiQ96KQ4.
KOiK17554.
OMAiRNRLNQE.
OrthoDBiEOG73FQKX.
PhylomeDBiQ96KQ4.
TreeFamiTF105545.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR028319. ASPP_1.
IPR001452. SH3_domain.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PANTHERiPTHR24131:SF5. PTHR24131:SF5. 1 hit.
PfamiPF00023. Ank. 2 hits.
PF00018. SH3_1. 1 hit.
[Graphical view]
PRINTSiPR00452. SH3DOMAIN.
SMARTiSM00248. ANK. 2 hits.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
SSF50044. SSF50044. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 2 hits.
PS50002. SH3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96KQ4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MMPMILTVFL SNNEQILTEV PITPETTCRD VVEFCKEPGE GSCHLAEVWR
60 70 80 90 100
GNERPIPFDH MMYEHLQKWG PRREEVKFFL RHEDSPTENS EQGGRQTQEQ
110 120 130 140 150
RTQRNVINVP GEKRTENGVG NPRVELTLSE LQDMAARQQQ QIENQQQMLV
160 170 180 190 200
AKEQRLHFLK QQERRQQQSI SENEKLQKLK ERVEAQENKL KKIRAMRGQV
210 220 230 240 250
DYSKIMNGNL SAEIERFSAM FQEKKQEVQT AILRVDQLSQ QLEDLKKGKL
260 270 280 290 300
NGFQSYNGKL TGPAAVELKR LYQELQIRNQ LNQEQNSKLQ QQKELLNKRN
310 320 330 340 350
MEVAMMDKRI SELRERLYGK KIQLNRVNGT SSPQSPLSTS GRVAAVGPYI
360 370 380 390 400
QVPSAGSFPV LGDPIKPQSL SIASNAAHGR SKSANDGNWP TLKQNSSSSV
410 420 430 440 450
KPVQVAGADW KDPSVEGSVK QGTVSSQPVP FSALGPTEKP GIEIGKVPPP
460 470 480 490 500
IPGVGKQLPP SYGTYPSPTP LGPGSTSSLE RRKEGSLPRP SAGLPSRQRP
510 520 530 540 550
TLLPATGSTP QPGSSQQIQQ RISVPPSPTY PPAGPPAFPA GDSKPELPLT
560 570 580 590 600
VAIRPFLADK GSRPQSPRKG PQTVNSSSIY SMYLQQATPP KNYQPAAHSA
610 620 630 640 650
LNKSVKAVYG KPVLPSGSTS PSPLPFLHGS LSTGTPQPQP PSESTEKEPE
660 670 680 690 700
QDGPAAPADG STVESLPRPL SPTKLTPIVH SPLRYQSDAD LEALRRKLAN
710 720 730 740 750
APRPLKKRSS ITEPEGPGGP NIQKLLYQRF NTLAGGMEGT PFYQPSPSQD
760 770 780 790 800
FMGTLADVDN GNTNANGNLE ELPPAQPTAP LPAEPAPSSD ANDNELPSPE
810 820 830 840 850
PEELICPQTT HQTAEPAEDN NNNVATVPTT EQIPSPVAEA PSPGEEQVPP
860 870 880 890 900
APLPPASHPP ATSTNKRTNL KKPNSERTGH GLRVRFNPLA LLLDASLEGE
910 920 930 940 950
FDLVQRIIYE VEDPSKPNDE GITPLHNAVC AGHHHIVKFL LDFGVNVNAA
960 970 980 990 1000
DSDGWTPLHC AASCNSVHLC KQLVESGAAI FASTISDIET AADKCEEMEE
1010 1020 1030 1040 1050
GYIQCSQFLY GVQEKLGVMN KGVAYALWDY EAQNSDELSF HEGDALTILR
1060 1070 1080 1090
RKDESETEWW WARLGDREGY VPKNLLGLYP RIKPRQRTLA
Length:1,090
Mass (Da):119,565
Last modified:May 18, 2010 - v3
Checksum:i0026F07D7AB33295
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti68 – 681K → I in CAC83011. (PubMed:11684014)Curated
Sequence conflicti112 – 1121E → D in CAC83011. (PubMed:11684014)Curated
Sequence conflicti117 – 1171N → Y in CAC83011. (PubMed:11684014)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ318887 mRNA. Translation: CAC83011.2.
AL049840 Genomic DNA. No translation available.
CH471061 Genomic DNA. Translation: EAW81847.1.
BC136527 mRNA. Translation: AAI36528.1.
AB018314 mRNA. Translation: BAA34491.1.
CCDSiCCDS41997.1.
RefSeqiNP_056131.2. NM_015316.2.
UniGeneiHs.709297.

Genome annotation databases

EnsembliENST00000202556; ENSP00000202556; ENSG00000088808.
GeneIDi23368.
KEGGihsa:23368.
UCSCiuc001yof.1. human.

Polymorphism databases

DMDMi296439434.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ318887 mRNA. Translation: CAC83011.2.
AL049840 Genomic DNA. No translation available.
CH471061 Genomic DNA. Translation: EAW81847.1.
BC136527 mRNA. Translation: AAI36528.1.
AB018314 mRNA. Translation: BAA34491.1.
CCDSiCCDS41997.1.
RefSeqiNP_056131.2. NM_015316.2.
UniGeneiHs.709297.

3D structure databases

ProteinModelPortaliQ96KQ4.
SMRiQ96KQ4. Positions 1-83, 887-1083.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116948. 21 interactions.
IntActiQ96KQ4. 22 interactions.
MINTiMINT-1130841.
STRINGi9606.ENSP00000202556.

PTM databases

PhosphoSiteiQ96KQ4.

Polymorphism databases

DMDMi296439434.

Proteomic databases

MaxQBiQ96KQ4.
PaxDbiQ96KQ4.
PRIDEiQ96KQ4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000202556; ENSP00000202556; ENSG00000088808.
GeneIDi23368.
KEGGihsa:23368.
UCSCiuc001yof.1. human.

Organism-specific databases

CTDi23368.
GeneCardsiGC14M104200.
H-InvDBHIX0012009.
HGNCiHGNC:14950. PPP1R13B.
HPAiCAB015454.
HPA006394.
MIMi606455. gene.
neXtProtiNX_Q96KQ4.
PharmGKBiPA33622.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG283717.
GeneTreeiENSGT00760000119141.
HOGENOMiHOG000034106.
HOVERGENiHBG050596.
InParanoidiQ96KQ4.
KOiK17554.
OMAiRNRLNQE.
OrthoDBiEOG73FQKX.
PhylomeDBiQ96KQ4.
TreeFamiTF105545.

Miscellaneous databases

ChiTaRSiPPP1R13B. human.
GeneWikiiPPP1R13B.
GenomeRNAii23368.
NextBioi45436.
PROiQ96KQ4.
SOURCEiSearch...

Gene expression databases

BgeeiQ96KQ4.
CleanExiHS_PPP1R13B.
ExpressionAtlasiQ96KQ4. baseline and differential.
GenevestigatoriQ96KQ4.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR028319. ASPP_1.
IPR001452. SH3_domain.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PANTHERiPTHR24131:SF5. PTHR24131:SF5. 1 hit.
PfamiPF00023. Ank. 2 hits.
PF00018. SH3_1. 1 hit.
[Graphical view]
PRINTSiPR00452. SH3DOMAIN.
SMARTiSM00248. ANK. 2 hits.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
SSF50044. SSF50044. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 2 hits.
PS50002. SH3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INTERACTION WITH TP53.
  2. "The DNA sequence and analysis of human chromosome 14."
    Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H.
    , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
    Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Ishikawa K., Suyama M., Kikuno R., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 5:277-286(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 143-1090.
    Tissue: Brain.
  6. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-681, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  7. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-332 AND SER-335, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.

Entry informationi

Entry nameiASPP1_HUMAN
AccessioniPrimary (citable) accession number: Q96KQ4
Secondary accession number(s): B2RMX5, O94870
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 15, 2003
Last sequence update: May 18, 2010
Last modified: February 4, 2015
This is version 109 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

In contrast to its official gene name, it is not a regulatory subunit of protein phosphatase 1. This name was given due to its similarity with a protein that binds to protein phosphatase 1.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.