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Q96KQ4

- ASPP1_HUMAN

UniProt

Q96KQ4 - ASPP1_HUMAN

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Protein

Apoptosis-stimulating of p53 protein 1

Gene
PPP1R13B, ASPP1, KIAA0771
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Regulator that plays a central role in regulation of apoptosis via its interaction with p53/TP53. Regulates TP53 by enhancing the DNA binding and transactivation function of TP53 on the promoters of proapoptotic genes in vivo.1 Publication

GO - Molecular functioni

  1. protein binding Source: UniProtKB

GO - Biological processi

  1. intrinsic apoptotic signaling pathway by p53 class mediator Source: UniProtKB
  2. negative regulation of cell cycle Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Apoptosis

Names & Taxonomyi

Protein namesi
Recommended name:
Apoptosis-stimulating of p53 protein 1
Alternative name(s):
Protein phosphatase 1 regulatory subunit 13B
Gene namesi
Synonyms:ASPP1, KIAA0771
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 14

Organism-specific databases

HGNCiHGNC:14950. PPP1R13B.

Subcellular locationi

Cytoplasm. Nucleus
Note: Predominantly cytoplasmic. Some fraction is nuclear.1 Publication

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. nucleus Source: UniProtKB
  3. plasma membrane Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA33622.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10901090Apoptosis-stimulating of p53 protein 1PRO_0000066962Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei332 – 3321Phosphoserine1 Publication
Modified residuei335 – 3351Phosphoserine1 Publication
Modified residuei681 – 6811Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ96KQ4.
PaxDbiQ96KQ4.
PRIDEiQ96KQ4.

PTM databases

PhosphoSiteiQ96KQ4.

Expressioni

Tissue specificityi

Reduced expression in breast carcinomas expressing a wild-type TP53 protein.1 Publication

Gene expression databases

ArrayExpressiQ96KQ4.
BgeeiQ96KQ4.
CleanExiHS_PPP1R13B.
GenevestigatoriQ96KQ4.

Organism-specific databases

HPAiCAB015454.
HPA006394.

Interactioni

Subunit structurei

Interacts with TP53.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
EP300Q094722EBI-1105153,EBI-447295
PPP1CAP621365EBI-1105153,EBI-357253

Protein-protein interaction databases

BioGridi116948. 14 interactions.
IntActiQ96KQ4. 22 interactions.
MINTiMINT-1130841.
STRINGi9606.ENSP00000202556.

Structurei

3D structure databases

ProteinModelPortaliQ96KQ4.
SMRiQ96KQ4. Positions 1-83, 887-1083.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati920 – 95233ANK 1Add
BLAST
Repeati953 – 98533ANK 2Add
BLAST
Domaini1019 – 108163SH3Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi132 – 292161Gln-richAdd
BLAST
Compositional biasi428 – 860433Pro-richAdd
BLAST

Domaini

The ankyrin repeats and the SH3 domain are required for specific interactions with TP53.

Sequence similaritiesi

Belongs to the ASPP family.
Contains 2 ANK repeats.
Contains 1 SH3 domain.

Keywords - Domaini

ANK repeat, Repeat, SH3 domain

Phylogenomic databases

eggNOGiNOG283717.
HOGENOMiHOG000034106.
HOVERGENiHBG050596.
InParanoidiQ96KQ4.
KOiK17554.
OMAiKLTPMVH.
OrthoDBiEOG73FQKX.
PhylomeDBiQ96KQ4.
TreeFamiTF105545.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR028319. ASPP_1.
IPR001452. SH3_domain.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PANTHERiPTHR24131:SF5. PTHR24131:SF5. 1 hit.
PfamiPF00023. Ank. 2 hits.
PF00018. SH3_1. 1 hit.
[Graphical view]
PRINTSiPR00452. SH3DOMAIN.
SMARTiSM00248. ANK. 2 hits.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
SSF50044. SSF50044. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 2 hits.
PS50002. SH3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96KQ4-1 [UniParc]FASTAAdd to Basket

« Hide

MMPMILTVFL SNNEQILTEV PITPETTCRD VVEFCKEPGE GSCHLAEVWR     50
GNERPIPFDH MMYEHLQKWG PRREEVKFFL RHEDSPTENS EQGGRQTQEQ 100
RTQRNVINVP GEKRTENGVG NPRVELTLSE LQDMAARQQQ QIENQQQMLV 150
AKEQRLHFLK QQERRQQQSI SENEKLQKLK ERVEAQENKL KKIRAMRGQV 200
DYSKIMNGNL SAEIERFSAM FQEKKQEVQT AILRVDQLSQ QLEDLKKGKL 250
NGFQSYNGKL TGPAAVELKR LYQELQIRNQ LNQEQNSKLQ QQKELLNKRN 300
MEVAMMDKRI SELRERLYGK KIQLNRVNGT SSPQSPLSTS GRVAAVGPYI 350
QVPSAGSFPV LGDPIKPQSL SIASNAAHGR SKSANDGNWP TLKQNSSSSV 400
KPVQVAGADW KDPSVEGSVK QGTVSSQPVP FSALGPTEKP GIEIGKVPPP 450
IPGVGKQLPP SYGTYPSPTP LGPGSTSSLE RRKEGSLPRP SAGLPSRQRP 500
TLLPATGSTP QPGSSQQIQQ RISVPPSPTY PPAGPPAFPA GDSKPELPLT 550
VAIRPFLADK GSRPQSPRKG PQTVNSSSIY SMYLQQATPP KNYQPAAHSA 600
LNKSVKAVYG KPVLPSGSTS PSPLPFLHGS LSTGTPQPQP PSESTEKEPE 650
QDGPAAPADG STVESLPRPL SPTKLTPIVH SPLRYQSDAD LEALRRKLAN 700
APRPLKKRSS ITEPEGPGGP NIQKLLYQRF NTLAGGMEGT PFYQPSPSQD 750
FMGTLADVDN GNTNANGNLE ELPPAQPTAP LPAEPAPSSD ANDNELPSPE 800
PEELICPQTT HQTAEPAEDN NNNVATVPTT EQIPSPVAEA PSPGEEQVPP 850
APLPPASHPP ATSTNKRTNL KKPNSERTGH GLRVRFNPLA LLLDASLEGE 900
FDLVQRIIYE VEDPSKPNDE GITPLHNAVC AGHHHIVKFL LDFGVNVNAA 950
DSDGWTPLHC AASCNSVHLC KQLVESGAAI FASTISDIET AADKCEEMEE 1000
GYIQCSQFLY GVQEKLGVMN KGVAYALWDY EAQNSDELSF HEGDALTILR 1050
RKDESETEWW WARLGDREGY VPKNLLGLYP RIKPRQRTLA 1090
Length:1,090
Mass (Da):119,565
Last modified:May 18, 2010 - v3
Checksum:i0026F07D7AB33295
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti68 – 681K → I in CAC83011. 1 Publication
Sequence conflicti112 – 1121E → D in CAC83011. 1 Publication
Sequence conflicti117 – 1171N → Y in CAC83011. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ318887 mRNA. Translation: CAC83011.2.
AL049840 Genomic DNA. No translation available.
CH471061 Genomic DNA. Translation: EAW81847.1.
BC136527 mRNA. Translation: AAI36528.1.
AB018314 mRNA. Translation: BAA34491.1.
CCDSiCCDS41997.1.
RefSeqiNP_056131.2. NM_015316.2.
UniGeneiHs.709297.

Genome annotation databases

EnsembliENST00000202556; ENSP00000202556; ENSG00000088808.
GeneIDi23368.
KEGGihsa:23368.
UCSCiuc001yof.1. human.

Polymorphism databases

DMDMi296439434.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ318887 mRNA. Translation: CAC83011.2 .
AL049840 Genomic DNA. No translation available.
CH471061 Genomic DNA. Translation: EAW81847.1 .
BC136527 mRNA. Translation: AAI36528.1 .
AB018314 mRNA. Translation: BAA34491.1 .
CCDSi CCDS41997.1.
RefSeqi NP_056131.2. NM_015316.2.
UniGenei Hs.709297.

3D structure databases

ProteinModelPortali Q96KQ4.
SMRi Q96KQ4. Positions 1-83, 887-1083.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 116948. 14 interactions.
IntActi Q96KQ4. 22 interactions.
MINTi MINT-1130841.
STRINGi 9606.ENSP00000202556.

PTM databases

PhosphoSitei Q96KQ4.

Polymorphism databases

DMDMi 296439434.

Proteomic databases

MaxQBi Q96KQ4.
PaxDbi Q96KQ4.
PRIDEi Q96KQ4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000202556 ; ENSP00000202556 ; ENSG00000088808 .
GeneIDi 23368.
KEGGi hsa:23368.
UCSCi uc001yof.1. human.

Organism-specific databases

CTDi 23368.
GeneCardsi GC14M104200.
H-InvDB HIX0012009.
HGNCi HGNC:14950. PPP1R13B.
HPAi CAB015454.
HPA006394.
MIMi 606455. gene.
neXtProti NX_Q96KQ4.
PharmGKBi PA33622.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG283717.
HOGENOMi HOG000034106.
HOVERGENi HBG050596.
InParanoidi Q96KQ4.
KOi K17554.
OMAi KLTPMVH.
OrthoDBi EOG73FQKX.
PhylomeDBi Q96KQ4.
TreeFami TF105545.

Miscellaneous databases

ChiTaRSi PPP1R13B. human.
GeneWikii PPP1R13B.
GenomeRNAii 23368.
NextBioi 45436.
PROi Q96KQ4.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q96KQ4.
Bgeei Q96KQ4.
CleanExi HS_PPP1R13B.
Genevestigatori Q96KQ4.

Family and domain databases

Gene3Di 1.25.40.20. 1 hit.
InterProi IPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR028319. ASPP_1.
IPR001452. SH3_domain.
IPR029071. Ubiquitin-rel_dom.
[Graphical view ]
PANTHERi PTHR24131:SF5. PTHR24131:SF5. 1 hit.
Pfami PF00023. Ank. 2 hits.
PF00018. SH3_1. 1 hit.
[Graphical view ]
PRINTSi PR00452. SH3DOMAIN.
SMARTi SM00248. ANK. 2 hits.
SM00326. SH3. 1 hit.
[Graphical view ]
SUPFAMi SSF48403. SSF48403. 1 hit.
SSF50044. SSF50044. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEi PS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 2 hits.
PS50002. SH3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INTERACTION WITH TP53.
  2. "The DNA sequence and analysis of human chromosome 14."
    Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H.
    , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
    Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Ishikawa K., Suyama M., Kikuno R., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 5:277-286(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 143-1090.
    Tissue: Brain.
  6. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-681, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  7. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-332 AND SER-335, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.

Entry informationi

Entry nameiASPP1_HUMAN
AccessioniPrimary (citable) accession number: Q96KQ4
Secondary accession number(s): B2RMX5, O94870
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 15, 2003
Last sequence update: May 18, 2010
Last modified: July 9, 2014
This is version 105 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

In contrast to its official gene name, it is not a regulatory subunit of protein phosphatase 1. This name was given due to its similarity with a protein that binds to protein phosphatase 1.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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