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Q96KQ4

- ASPP1_HUMAN

UniProt

Q96KQ4 - ASPP1_HUMAN

Protein

Apoptosis-stimulating of p53 protein 1

Gene

PPP1R13B

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 106 (01 Oct 2014)
      Sequence version 3 (18 May 2010)
      Previous versions | rss
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    Functioni

    Regulator that plays a central role in regulation of apoptosis via its interaction with p53/TP53. Regulates TP53 by enhancing the DNA binding and transactivation function of TP53 on the promoters of proapoptotic genes in vivo.1 Publication

    GO - Molecular functioni

    1. protein binding Source: UniProtKB

    GO - Biological processi

    1. intrinsic apoptotic signaling pathway by p53 class mediator Source: UniProtKB
    2. negative regulation of cell cycle Source: UniProtKB

    Keywords - Biological processi

    Apoptosis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Apoptosis-stimulating of p53 protein 1
    Alternative name(s):
    Protein phosphatase 1 regulatory subunit 13B
    Gene namesi
    Name:PPP1R13B
    Synonyms:ASPP1, KIAA0771
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 14

    Organism-specific databases

    HGNCiHGNC:14950. PPP1R13B.

    Subcellular locationi

    Cytoplasm 1 Publication. Nucleus 1 Publication
    Note: Predominantly cytoplasmic. Some fraction is nuclear.

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. nucleus Source: UniProtKB
    3. plasma membrane Source: HPA

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA33622.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 10901090Apoptosis-stimulating of p53 protein 1PRO_0000066962Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei332 – 3321Phosphoserine1 Publication
    Modified residuei335 – 3351Phosphoserine1 Publication
    Modified residuei681 – 6811Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ96KQ4.
    PaxDbiQ96KQ4.
    PRIDEiQ96KQ4.

    PTM databases

    PhosphoSiteiQ96KQ4.

    Expressioni

    Tissue specificityi

    Reduced expression in breast carcinomas expressing a wild-type TP53 protein.1 Publication

    Gene expression databases

    ArrayExpressiQ96KQ4.
    BgeeiQ96KQ4.
    CleanExiHS_PPP1R13B.
    GenevestigatoriQ96KQ4.

    Organism-specific databases

    HPAiCAB015454.
    HPA006394.

    Interactioni

    Subunit structurei

    Interacts with TP53.1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    EP300Q094722EBI-1105153,EBI-447295
    PPP1CAP621365EBI-1105153,EBI-357253

    Protein-protein interaction databases

    BioGridi116948. 14 interactions.
    IntActiQ96KQ4. 22 interactions.
    MINTiMINT-1130841.
    STRINGi9606.ENSP00000202556.

    Structurei

    3D structure databases

    ProteinModelPortaliQ96KQ4.
    SMRiQ96KQ4. Positions 1-83, 887-1083.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati920 – 95233ANK 1Add
    BLAST
    Repeati953 – 98533ANK 2Add
    BLAST
    Domaini1019 – 108163SH3PROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi132 – 292161Gln-richAdd
    BLAST
    Compositional biasi428 – 860433Pro-richAdd
    BLAST

    Domaini

    The ankyrin repeats and the SH3 domain are required for specific interactions with TP53.

    Sequence similaritiesi

    Belongs to the ASPP family.Curated
    Contains 2 ANK repeats.PROSITE-ProRule annotation
    Contains 1 SH3 domain.PROSITE-ProRule annotation

    Keywords - Domaini

    ANK repeat, Repeat, SH3 domain

    Phylogenomic databases

    eggNOGiNOG283717.
    HOGENOMiHOG000034106.
    HOVERGENiHBG050596.
    InParanoidiQ96KQ4.
    KOiK17554.
    OMAiKLTPMVH.
    OrthoDBiEOG73FQKX.
    PhylomeDBiQ96KQ4.
    TreeFamiTF105545.

    Family and domain databases

    Gene3Di1.25.40.20. 1 hit.
    InterProiIPR002110. Ankyrin_rpt.
    IPR020683. Ankyrin_rpt-contain_dom.
    IPR028319. ASPP_1.
    IPR001452. SH3_domain.
    IPR029071. Ubiquitin-rel_dom.
    [Graphical view]
    PANTHERiPTHR24131:SF5. PTHR24131:SF5. 1 hit.
    PfamiPF00023. Ank. 2 hits.
    PF00018. SH3_1. 1 hit.
    [Graphical view]
    PRINTSiPR00452. SH3DOMAIN.
    SMARTiSM00248. ANK. 2 hits.
    SM00326. SH3. 1 hit.
    [Graphical view]
    SUPFAMiSSF48403. SSF48403. 1 hit.
    SSF50044. SSF50044. 1 hit.
    SSF54236. SSF54236. 1 hit.
    PROSITEiPS50297. ANK_REP_REGION. 1 hit.
    PS50088. ANK_REPEAT. 2 hits.
    PS50002. SH3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q96KQ4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MMPMILTVFL SNNEQILTEV PITPETTCRD VVEFCKEPGE GSCHLAEVWR     50
    GNERPIPFDH MMYEHLQKWG PRREEVKFFL RHEDSPTENS EQGGRQTQEQ 100
    RTQRNVINVP GEKRTENGVG NPRVELTLSE LQDMAARQQQ QIENQQQMLV 150
    AKEQRLHFLK QQERRQQQSI SENEKLQKLK ERVEAQENKL KKIRAMRGQV 200
    DYSKIMNGNL SAEIERFSAM FQEKKQEVQT AILRVDQLSQ QLEDLKKGKL 250
    NGFQSYNGKL TGPAAVELKR LYQELQIRNQ LNQEQNSKLQ QQKELLNKRN 300
    MEVAMMDKRI SELRERLYGK KIQLNRVNGT SSPQSPLSTS GRVAAVGPYI 350
    QVPSAGSFPV LGDPIKPQSL SIASNAAHGR SKSANDGNWP TLKQNSSSSV 400
    KPVQVAGADW KDPSVEGSVK QGTVSSQPVP FSALGPTEKP GIEIGKVPPP 450
    IPGVGKQLPP SYGTYPSPTP LGPGSTSSLE RRKEGSLPRP SAGLPSRQRP 500
    TLLPATGSTP QPGSSQQIQQ RISVPPSPTY PPAGPPAFPA GDSKPELPLT 550
    VAIRPFLADK GSRPQSPRKG PQTVNSSSIY SMYLQQATPP KNYQPAAHSA 600
    LNKSVKAVYG KPVLPSGSTS PSPLPFLHGS LSTGTPQPQP PSESTEKEPE 650
    QDGPAAPADG STVESLPRPL SPTKLTPIVH SPLRYQSDAD LEALRRKLAN 700
    APRPLKKRSS ITEPEGPGGP NIQKLLYQRF NTLAGGMEGT PFYQPSPSQD 750
    FMGTLADVDN GNTNANGNLE ELPPAQPTAP LPAEPAPSSD ANDNELPSPE 800
    PEELICPQTT HQTAEPAEDN NNNVATVPTT EQIPSPVAEA PSPGEEQVPP 850
    APLPPASHPP ATSTNKRTNL KKPNSERTGH GLRVRFNPLA LLLDASLEGE 900
    FDLVQRIIYE VEDPSKPNDE GITPLHNAVC AGHHHIVKFL LDFGVNVNAA 950
    DSDGWTPLHC AASCNSVHLC KQLVESGAAI FASTISDIET AADKCEEMEE 1000
    GYIQCSQFLY GVQEKLGVMN KGVAYALWDY EAQNSDELSF HEGDALTILR 1050
    RKDESETEWW WARLGDREGY VPKNLLGLYP RIKPRQRTLA 1090
    Length:1,090
    Mass (Da):119,565
    Last modified:May 18, 2010 - v3
    Checksum:i0026F07D7AB33295
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti68 – 681K → I in CAC83011. (PubMed:11684014)Curated
    Sequence conflicti112 – 1121E → D in CAC83011. (PubMed:11684014)Curated
    Sequence conflicti117 – 1171N → Y in CAC83011. (PubMed:11684014)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ318887 mRNA. Translation: CAC83011.2.
    AL049840 Genomic DNA. No translation available.
    CH471061 Genomic DNA. Translation: EAW81847.1.
    BC136527 mRNA. Translation: AAI36528.1.
    AB018314 mRNA. Translation: BAA34491.1.
    CCDSiCCDS41997.1.
    RefSeqiNP_056131.2. NM_015316.2.
    UniGeneiHs.709297.

    Genome annotation databases

    EnsembliENST00000202556; ENSP00000202556; ENSG00000088808.
    GeneIDi23368.
    KEGGihsa:23368.
    UCSCiuc001yof.1. human.

    Polymorphism databases

    DMDMi296439434.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ318887 mRNA. Translation: CAC83011.2 .
    AL049840 Genomic DNA. No translation available.
    CH471061 Genomic DNA. Translation: EAW81847.1 .
    BC136527 mRNA. Translation: AAI36528.1 .
    AB018314 mRNA. Translation: BAA34491.1 .
    CCDSi CCDS41997.1.
    RefSeqi NP_056131.2. NM_015316.2.
    UniGenei Hs.709297.

    3D structure databases

    ProteinModelPortali Q96KQ4.
    SMRi Q96KQ4. Positions 1-83, 887-1083.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 116948. 14 interactions.
    IntActi Q96KQ4. 22 interactions.
    MINTi MINT-1130841.
    STRINGi 9606.ENSP00000202556.

    PTM databases

    PhosphoSitei Q96KQ4.

    Polymorphism databases

    DMDMi 296439434.

    Proteomic databases

    MaxQBi Q96KQ4.
    PaxDbi Q96KQ4.
    PRIDEi Q96KQ4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000202556 ; ENSP00000202556 ; ENSG00000088808 .
    GeneIDi 23368.
    KEGGi hsa:23368.
    UCSCi uc001yof.1. human.

    Organism-specific databases

    CTDi 23368.
    GeneCardsi GC14M104200.
    H-InvDB HIX0012009.
    HGNCi HGNC:14950. PPP1R13B.
    HPAi CAB015454.
    HPA006394.
    MIMi 606455. gene.
    neXtProti NX_Q96KQ4.
    PharmGKBi PA33622.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG283717.
    HOGENOMi HOG000034106.
    HOVERGENi HBG050596.
    InParanoidi Q96KQ4.
    KOi K17554.
    OMAi KLTPMVH.
    OrthoDBi EOG73FQKX.
    PhylomeDBi Q96KQ4.
    TreeFami TF105545.

    Miscellaneous databases

    ChiTaRSi PPP1R13B. human.
    GeneWikii PPP1R13B.
    GenomeRNAii 23368.
    NextBioi 45436.
    PROi Q96KQ4.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q96KQ4.
    Bgeei Q96KQ4.
    CleanExi HS_PPP1R13B.
    Genevestigatori Q96KQ4.

    Family and domain databases

    Gene3Di 1.25.40.20. 1 hit.
    InterProi IPR002110. Ankyrin_rpt.
    IPR020683. Ankyrin_rpt-contain_dom.
    IPR028319. ASPP_1.
    IPR001452. SH3_domain.
    IPR029071. Ubiquitin-rel_dom.
    [Graphical view ]
    PANTHERi PTHR24131:SF5. PTHR24131:SF5. 1 hit.
    Pfami PF00023. Ank. 2 hits.
    PF00018. SH3_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00452. SH3DOMAIN.
    SMARTi SM00248. ANK. 2 hits.
    SM00326. SH3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48403. SSF48403. 1 hit.
    SSF50044. SSF50044. 1 hit.
    SSF54236. SSF54236. 1 hit.
    PROSITEi PS50297. ANK_REP_REGION. 1 hit.
    PS50088. ANK_REPEAT. 2 hits.
    PS50002. SH3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INTERACTION WITH TP53.
    2. "The DNA sequence and analysis of human chromosome 14."
      Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H.
      , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
      Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    5. "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
      Nagase T., Ishikawa K., Suyama M., Kikuno R., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
      DNA Res. 5:277-286(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 143-1090.
      Tissue: Brain.
    6. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-681, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    7. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-332 AND SER-335, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.

    Entry informationi

    Entry nameiASPP1_HUMAN
    AccessioniPrimary (citable) accession number: Q96KQ4
    Secondary accession number(s): B2RMX5, O94870
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 15, 2003
    Last sequence update: May 18, 2010
    Last modified: October 1, 2014
    This is version 106 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    In contrast to its official gene name, it is not a regulatory subunit of protein phosphatase 1. This name was given due to its similarity with a protein that binds to protein phosphatase 1.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 14
      Human chromosome 14: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3