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Protein

Exocyst complex component 2

Gene

EXOC2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.

GO - Molecular functioni

  • protein kinase binding Source: UniProtKB
  • Ral GTPase binding Source: UniProtKB

GO - Biological processi

  • exocyst assembly Source: GO_Central
  • Golgi to plasma membrane transport Source: InterPro
  • protein transport Source: UniProtKB-KW
  • regulation of entry of bacterium into host cell Source: AgBase
Complete GO annotation...

Keywords - Biological processi

Exocytosis, Protein transport, Transport

Enzyme and pathway databases

BioCyciZFISH:ENSG00000112685-MONOMER.
ReactomeiR-HSA-1445148. Translocation of GLUT4 to the plasma membrane.
R-HSA-264876. Insulin processing.
R-HSA-5620916. VxPx cargo-targeting to cilium.
SignaLinkiQ96KP1.

Names & Taxonomyi

Protein namesi
Recommended name:
Exocyst complex component 2
Alternative name(s):
Exocyst complex component Sec5
Gene namesi
Name:EXOC2
Synonyms:SEC5, SEC5L1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:24968. EXOC2.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: Reactome
  • exocyst Source: UniProtKB
  • intracellular membrane-bounded organelle Source: HPA
  • membrane Source: UniProtKB
  • plasma membrane Source: Reactome
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

DisGeNETi55770.
OpenTargetsiENSG00000112685.
PharmGKBiPA134862170.

Polymorphism and mutation databases

DMDMi24638219.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001189181 – 924Exocyst complex component 2Add BLAST924

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei431PhosphoserineCombined sources1
Modified residuei432PhosphoserineCombined sources1
Modified residuei435PhosphoserineCombined sources1
Modified residuei440PhosphothreonineCombined sources1
Modified residuei454N6-acetyllysineCombined sources1
Modified residuei888PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ96KP1.
MaxQBiQ96KP1.
PaxDbiQ96KP1.
PeptideAtlasiQ96KP1.
PRIDEiQ96KP1.

PTM databases

iPTMnetiQ96KP1.
PhosphoSitePlusiQ96KP1.

Expressioni

Tissue specificityi

Widely expressed with highest levels in brain and placenta.1 Publication

Gene expression databases

BgeeiENSG00000112685.
CleanExiHS_EXOC2.
ExpressionAtlasiQ96KP1. baseline and differential.
GenevisibleiQ96KP1. HS.

Organism-specific databases

HPAiHPA032093.
HPA032094.

Interactioni

Subunit structurei

The exocyst complex is composed of EXOC1, EXOC2, EXOC3, EXOC4, EXOC5, EXOC6, EXOC7 and EXOC8. Interacts with EXOC3L1 (By similarity). Interacts with RALA and GNEFR/DELGEF. Interaction with GNEFR occurs only in the presence of magnesium or manganese and is stimulated by dCTP or GTP. Interacts with RALB.By similarity2 Publications

GO - Molecular functioni

  • protein kinase binding Source: UniProtKB
  • Ral GTPase binding Source: UniProtKB

Protein-protein interaction databases

BioGridi120887. 39 interactors.
DIPiDIP-31795N.
IntActiQ96KP1. 14 interactors.
STRINGi9606.ENSP00000230449.

Structurei

3D structure databases

ProteinModelPortaliQ96KP1.
SMRiQ96KP1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 93IPT/TIGAdd BLAST86

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili240 – 260Sequence analysisAdd BLAST21

Domaini

Interacts with RALA through the TIG domain.By similarity

Sequence similaritiesi

Belongs to the SEC5 family.Curated
Contains 1 IPT/TIG domain.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG2347. Eukaryota.
ENOG410XSY3. LUCA.
GeneTreeiENSGT00390000010872.
HOGENOMiHOG000044231.
HOVERGENiHBG028469.
InParanoidiQ96KP1.
KOiK17637.
OMAiSWTKVTI.
OrthoDBiEOG091G02P6.
PhylomeDBiQ96KP1.
TreeFamiTF105891.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR029175. EXOC2/Sec5.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR002909. IPT.
[Graphical view]
PANTHERiPTHR13043. PTHR13043. 1 hit.
PfamiPF01833. TIG. 1 hit.
[Graphical view]
SUPFAMiSSF81296. SSF81296. 1 hit.

Sequencei

Sequence statusi: Complete.

Q96KP1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRSRQPPLV TGISPNEGIP WTKVTIRGEN LGTGPTDLIG LTICGHNCLL
60 70 80 90 100
TAEWMSASKI VCRVGQAKND KGDIIVTTKS GGRGTSTVSF KLLKPEKIGI
110 120 130 140 150
LDQSAVWVDE MNYYDMRTDR NKGIPPLSLR PANPLGIEIE KSKFSQKDLE
160 170 180 190 200
MLFHGMSADF TSENFSAAWY LIENHSNTSF EQLKMAVTNL KRQANKKSEG
210 220 230 240 250
SLAYVKGGLS TFFEAQDALS AIHQKLEADG TEKVEGSMTQ KLENVLNRAS
260 270 280 290 300
NTADTLFQEV LGRKDKADST RNALNVLQRF KFLFNLPLNI ERNIQKGDYD
310 320 330 340 350
VVINDYEKAK SLFGKTEVQV FKKYYAEVET RIEALRELLL DKLLETPSTL
360 370 380 390 400
HDQKRYIRYL SDLHASGDPA WQCIGAQHKW ILQLMHSCKE GYVKDLKGNP
410 420 430 440 450
GLHSPMLDLD NDTRPSVLGH LSQTASLKRG SSFQSGRDDT WRYKTPHRVA
460 470 480 490 500
FVEKLTKLVL SQLPNFWKLW ISYVNGSLFS ETAEKSGQIE RSKNVRQRQN
510 520 530 540 550
DFKKMIQEVM HSLVKLTRGA LLPLSIRDGE AKQYGGWEVK CELSGQWLAH
560 570 580 590 600
AIQTVRLTHE SLTALEIPND LLQTIQDLIL DLRVRCVMAT LQHTAEEIKR
610 620 630 640 650
LAEKEDWIVD NEGLTSLPCQ FEQCIVCSLQ SLKGVLECKP GEASVFQQPK
660 670 680 690 700
TQEEVCQLSI NIMQVFIYCL EQLSTKPDAD IDTTHLSVDV SSPDLFGSIH
710 720 730 740 750
EDFSLTSEQR LLIVLSNCCY LERHTFLNIA EHFEKHNFQG IEKITQVSMA
760 770 780 790 800
SLKELDQRLF ENYIELKADP IVGSLEPGIY AGYFDWKDCL PPTGVRNYLK
810 820 830 840 850
EALVNIIAVH AEVFTISKEL VPRVLSKVIE AVSEELSRLM QCVSSFSKNG
860 870 880 890 900
ALQARLEICA LRDTVAVYLT PESKSSFKQA LEALPQLSSG ADKKLLEELL
910 920
NKFKSSMHLQ LTCFQAASST MMKT
Length:924
Mass (Da):104,066
Last modified:December 1, 2001 - v1
Checksum:i2234E463DE8B076F
GO

Sequence cautioni

The sequence BAA91963 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti19I → K in BAG37193 (PubMed:14702039).Curated1
Sequence conflicti522L → H in BAA91963 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_048956195N → T.Corresponds to variant rs35600069dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ414403 mRNA. Translation: CAC92092.1.
AK001888 mRNA. Translation: BAA91963.1. Different initiation.
AK314628 mRNA. Translation: BAG37193.1.
AL833213 mRNA. Translation: CAI46189.1.
AL031770, AL512308 Genomic DNA. Translation: CAI19790.1.
AL512308, AL031770 Genomic DNA. Translation: CAH70772.1.
BC016918 mRNA. Translation: AAH16918.2.
BC080542 mRNA. Translation: AAH80542.1.
CCDSiCCDS34327.1.
RefSeqiNP_060773.3. NM_018303.5.
XP_016866507.1. XM_017011018.1.
XP_016866508.1. XM_017011019.1.
XP_016866509.1. XM_017011020.1.
XP_016866510.1. XM_017011021.1.
XP_016866511.1. XM_017011022.1.
XP_016866512.1. XM_017011023.1.
XP_016866513.1. XM_017011024.1.
UniGeneiHs.484412.

Genome annotation databases

EnsembliENST00000230449; ENSP00000230449; ENSG00000112685.
GeneIDi55770.
KEGGihsa:55770.
UCSCiuc003mtd.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ414403 mRNA. Translation: CAC92092.1.
AK001888 mRNA. Translation: BAA91963.1. Different initiation.
AK314628 mRNA. Translation: BAG37193.1.
AL833213 mRNA. Translation: CAI46189.1.
AL031770, AL512308 Genomic DNA. Translation: CAI19790.1.
AL512308, AL031770 Genomic DNA. Translation: CAH70772.1.
BC016918 mRNA. Translation: AAH16918.2.
BC080542 mRNA. Translation: AAH80542.1.
CCDSiCCDS34327.1.
RefSeqiNP_060773.3. NM_018303.5.
XP_016866507.1. XM_017011018.1.
XP_016866508.1. XM_017011019.1.
XP_016866509.1. XM_017011020.1.
XP_016866510.1. XM_017011021.1.
XP_016866511.1. XM_017011022.1.
XP_016866512.1. XM_017011023.1.
XP_016866513.1. XM_017011024.1.
UniGeneiHs.484412.

3D structure databases

ProteinModelPortaliQ96KP1.
SMRiQ96KP1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120887. 39 interactors.
DIPiDIP-31795N.
IntActiQ96KP1. 14 interactors.
STRINGi9606.ENSP00000230449.

PTM databases

iPTMnetiQ96KP1.
PhosphoSitePlusiQ96KP1.

Polymorphism and mutation databases

DMDMi24638219.

Proteomic databases

EPDiQ96KP1.
MaxQBiQ96KP1.
PaxDbiQ96KP1.
PeptideAtlasiQ96KP1.
PRIDEiQ96KP1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000230449; ENSP00000230449; ENSG00000112685.
GeneIDi55770.
KEGGihsa:55770.
UCSCiuc003mtd.5. human.

Organism-specific databases

CTDi55770.
DisGeNETi55770.
GeneCardsiEXOC2.
HGNCiHGNC:24968. EXOC2.
HPAiHPA032093.
HPA032094.
MIMi615329. gene.
neXtProtiNX_Q96KP1.
OpenTargetsiENSG00000112685.
PharmGKBiPA134862170.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2347. Eukaryota.
ENOG410XSY3. LUCA.
GeneTreeiENSGT00390000010872.
HOGENOMiHOG000044231.
HOVERGENiHBG028469.
InParanoidiQ96KP1.
KOiK17637.
OMAiSWTKVTI.
OrthoDBiEOG091G02P6.
PhylomeDBiQ96KP1.
TreeFamiTF105891.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000112685-MONOMER.
ReactomeiR-HSA-1445148. Translocation of GLUT4 to the plasma membrane.
R-HSA-264876. Insulin processing.
R-HSA-5620916. VxPx cargo-targeting to cilium.
SignaLinkiQ96KP1.

Miscellaneous databases

ChiTaRSiEXOC2. human.
GeneWikiiEXOC2.
GenomeRNAii55770.
PROiQ96KP1.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000112685.
CleanExiHS_EXOC2.
ExpressionAtlasiQ96KP1. baseline and differential.
GenevisibleiQ96KP1. HS.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR029175. EXOC2/Sec5.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR002909. IPT.
[Graphical view]
PANTHERiPTHR13043. PTHR13043. 1 hit.
PfamiPF01833. TIG. 1 hit.
[Graphical view]
SUPFAMiSSF81296. SSF81296. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiEXOC2_HUMAN
AccessioniPrimary (citable) accession number: Q96KP1
Secondary accession number(s): B2RBE6
, Q5JPC8, Q96AN6, Q9NUZ8, Q9UJM7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 2002
Last sequence update: December 1, 2001
Last modified: November 30, 2016
This is version 143 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.