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Protein

Exocyst complex component 2

Gene

EXOC2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.

GO - Molecular functioni

  • protein kinase binding Source: UniProtKB
  • protein N-terminus binding Source: Ensembl
  • Ral GTPase binding Source: UniProtKB

GO - Biological processi

  • exocyst assembly Source: GO_Central
  • Golgi to plasma membrane transport Source: InterPro
  • protein transport Source: UniProtKB-KW
  • regulation of entry of bacterium into host cell Source: AgBase

Keywordsi

Biological processExocytosis, Protein transport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-1445148 Translocation of GLUT4 to the plasma membrane
R-HSA-264876 Insulin processing
R-HSA-5620916 VxPx cargo-targeting to cilium
SignaLinkiQ96KP1

Protein family/group databases

TCDBi1.F.2.1.2 the octameric exocyst (exocyst) family

Names & Taxonomyi

Protein namesi
Recommended name:
Exocyst complex component 2
Alternative name(s):
Exocyst complex component Sec5
Gene namesi
Name:EXOC2
Synonyms:SEC5, SEC5L1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000112685.13
HGNCiHGNC:24968 EXOC2
MIMi615329 gene
neXtProtiNX_Q96KP1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi11T → A: Impaired cytokinesis. Loss of RALA-binding. No change in localization to the midbody during cytokinesis. 1 Publication1

Organism-specific databases

DisGeNETi55770
OpenTargetsiENSG00000112685
PharmGKBiPA134862170

Polymorphism and mutation databases

DMDMi24638219

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001189181 – 924Exocyst complex component 2Add BLAST924

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei431PhosphoserineCombined sources1
Modified residuei432PhosphoserineCombined sources1
Modified residuei435PhosphoserineCombined sources1
Modified residuei440PhosphothreonineCombined sources1
Modified residuei454N6-acetyllysineCombined sources1
Modified residuei888PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ96KP1
MaxQBiQ96KP1
PaxDbiQ96KP1
PeptideAtlasiQ96KP1
PRIDEiQ96KP1

PTM databases

iPTMnetiQ96KP1
PhosphoSitePlusiQ96KP1

Expressioni

Tissue specificityi

Widely expressed with highest levels in brain and placenta.1 Publication

Gene expression databases

BgeeiENSG00000112685
CleanExiHS_EXOC2
ExpressionAtlasiQ96KP1 baseline and differential
GenevisibleiQ96KP1 HS

Organism-specific databases

HPAiHPA032093

Interactioni

Subunit structurei

The exocyst complex is composed of EXOC1, EXOC2, EXOC3, EXOC4, EXOC5, EXOC6, EXOC7 and EXOC8 (By similarity). Interacts with EXOC3L1 (By similarity). Interacts with GNEFR/DELGEF; this interaction occurs only in the presence of magnesium or manganese and is stimulated by dCTP or GTP (PubMed:12459492). Interacts with RALA and RALB (PubMed:18756269, PubMed:19166349).By similarity3 Publications

Binary interactionsi

Show more details

GO - Molecular functioni

  • protein kinase binding Source: UniProtKB
  • protein N-terminus binding Source: Ensembl
  • Ral GTPase binding Source: UniProtKB

Protein-protein interaction databases

BioGridi12088747 interactors.
CORUMiQ96KP1
DIPiDIP-31795N
IntActiQ96KP1 18 interactors.
MINTiQ96KP1
STRINGi9606.ENSP00000230449

Structurei

3D structure databases

ProteinModelPortaliQ96KP1
SMRiQ96KP1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 93IPT/TIGAdd BLAST86

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili240 – 260Sequence analysisAdd BLAST21

Domaini

Interacts with RALA through the TIG domain.By similarity

Sequence similaritiesi

Belongs to the SEC5 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG2347 Eukaryota
ENOG410XSY3 LUCA
GeneTreeiENSGT00390000010872
HOGENOMiHOG000044231
HOVERGENiHBG028469
InParanoidiQ96KP1
KOiK17637
OMAiGMQKILY
OrthoDBiEOG091G02P6
PhylomeDBiQ96KP1
TreeFamiTF105891

Family and domain databases

Gene3Di2.60.40.101 hit
InterProiView protein in InterPro
IPR029175 EXOC2/Sec5
IPR013783 Ig-like_fold
IPR014756 Ig_E-set
IPR002909 IPT_dom
PANTHERiPTHR13043 PTHR13043, 1 hit
PfamiView protein in Pfam
PF01833 TIG, 1 hit
SUPFAMiSSF81296 SSF81296, 1 hit

Sequencei

Sequence statusi: Complete.

Q96KP1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRSRQPPLV TGISPNEGIP WTKVTIRGEN LGTGPTDLIG LTICGHNCLL
60 70 80 90 100
TAEWMSASKI VCRVGQAKND KGDIIVTTKS GGRGTSTVSF KLLKPEKIGI
110 120 130 140 150
LDQSAVWVDE MNYYDMRTDR NKGIPPLSLR PANPLGIEIE KSKFSQKDLE
160 170 180 190 200
MLFHGMSADF TSENFSAAWY LIENHSNTSF EQLKMAVTNL KRQANKKSEG
210 220 230 240 250
SLAYVKGGLS TFFEAQDALS AIHQKLEADG TEKVEGSMTQ KLENVLNRAS
260 270 280 290 300
NTADTLFQEV LGRKDKADST RNALNVLQRF KFLFNLPLNI ERNIQKGDYD
310 320 330 340 350
VVINDYEKAK SLFGKTEVQV FKKYYAEVET RIEALRELLL DKLLETPSTL
360 370 380 390 400
HDQKRYIRYL SDLHASGDPA WQCIGAQHKW ILQLMHSCKE GYVKDLKGNP
410 420 430 440 450
GLHSPMLDLD NDTRPSVLGH LSQTASLKRG SSFQSGRDDT WRYKTPHRVA
460 470 480 490 500
FVEKLTKLVL SQLPNFWKLW ISYVNGSLFS ETAEKSGQIE RSKNVRQRQN
510 520 530 540 550
DFKKMIQEVM HSLVKLTRGA LLPLSIRDGE AKQYGGWEVK CELSGQWLAH
560 570 580 590 600
AIQTVRLTHE SLTALEIPND LLQTIQDLIL DLRVRCVMAT LQHTAEEIKR
610 620 630 640 650
LAEKEDWIVD NEGLTSLPCQ FEQCIVCSLQ SLKGVLECKP GEASVFQQPK
660 670 680 690 700
TQEEVCQLSI NIMQVFIYCL EQLSTKPDAD IDTTHLSVDV SSPDLFGSIH
710 720 730 740 750
EDFSLTSEQR LLIVLSNCCY LERHTFLNIA EHFEKHNFQG IEKITQVSMA
760 770 780 790 800
SLKELDQRLF ENYIELKADP IVGSLEPGIY AGYFDWKDCL PPTGVRNYLK
810 820 830 840 850
EALVNIIAVH AEVFTISKEL VPRVLSKVIE AVSEELSRLM QCVSSFSKNG
860 870 880 890 900
ALQARLEICA LRDTVAVYLT PESKSSFKQA LEALPQLSSG ADKKLLEELL
910 920
NKFKSSMHLQ LTCFQAASST MMKT
Length:924
Mass (Da):104,066
Last modified:December 1, 2001 - v1
Checksum:i2234E463DE8B076F
GO

Sequence cautioni

The sequence BAA91963 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti19I → K in BAG37193 (PubMed:14702039).Curated1
Sequence conflicti522L → H in BAA91963 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_048956195N → T. Corresponds to variant dbSNP:rs35600069Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ414403 mRNA Translation: CAC92092.1
AK001888 mRNA Translation: BAA91963.1 Different initiation.
AK314628 mRNA Translation: BAG37193.1
AL833213 mRNA Translation: CAI46189.1
AL031770 Genomic DNA No translation available.
AL512308 Genomic DNA No translation available.
BC016918 mRNA Translation: AAH16918.2
BC080542 mRNA Translation: AAH80542.1
CCDSiCCDS34327.1
RefSeqiNP_060773.3, NM_018303.5
XP_016866507.1, XM_017011018.1
XP_016866508.1, XM_017011019.1
XP_016866509.1, XM_017011020.1
XP_016866510.1, XM_017011021.1
XP_016866511.1, XM_017011022.1
XP_016866512.1, XM_017011023.1
XP_016866513.1, XM_017011024.1
UniGeneiHs.484412

Genome annotation databases

EnsembliENST00000230449; ENSP00000230449; ENSG00000112685
GeneIDi55770
KEGGihsa:55770
UCSCiuc003mtd.5 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiEXOC2_HUMAN
AccessioniPrimary (citable) accession number: Q96KP1
Secondary accession number(s): B2RBE6
, Q5JPC8, Q96AN6, Q9NUZ8, Q9UJM7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 2002
Last sequence update: December 1, 2001
Last modified: April 25, 2018
This is version 157 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome