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Protein

Protein FAM84A

Gene

FAM84A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Protein FAM84A
Alternative name(s):
Neurologic sensory protein 1
Short name:
NSE1
Gene namesi
Name:FAM84A
Synonyms:NSE1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:20743. FAM84A.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142671854.

Polymorphism and mutation databases

BioMutaiFAM84A.
DMDMi97049335.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 292292Protein FAM84APRO_0000234425Add
BLAST

Post-translational modificationi

Isoform 2 is phosphorylated.

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ96KN4.
PaxDbiQ96KN4.
PeptideAtlasiQ96KN4.
PRIDEiQ96KN4.

PTM databases

iPTMnetiQ96KN4.
PhosphoSiteiQ96KN4.

Expressioni

Gene expression databases

BgeeiQ96KN4.
CleanExiHS_FAM84A.
GenevisibleiQ96KN4. HS.

Organism-specific databases

HPAiHPA047703.

Interactioni

Protein-protein interaction databases

BioGridi127371. 1 interaction.
IntActiQ96KN4. 1 interaction.
STRINGi9606.ENSP00000295092.

Structurei

3D structure databases

ProteinModelPortaliQ96KN4.
SMRiQ96KN4. Positions 118-224.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi71 – 744Poly-His

Sequence similaritiesi

Belongs to the FAM84 family.Curated

Phylogenomic databases

eggNOGiENOG410IJCX. Eukaryota.
ENOG4111FA5. LUCA.
GeneTreeiENSGT00390000013755.
HOGENOMiHOG000293400.
HOVERGENiHBG054465.
InParanoidiQ96KN4.
OMAiCIFSKLR.
OrthoDBiEOG7HXCRJ.
PhylomeDBiQ96KN4.
TreeFamiTF330836.

Family and domain databases

InterProiIPR007053. LRAT-like_dom.
[Graphical view]
PfamiPF04970. LRAT. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96KN4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGNQLDRITH LNYSELPTGD PSGIEKDELR VGVAYFFSDD EEDLDERGQP
60 70 80 90 100
DKFGVKAPPG CTPCPESPSR HHHHLLHQLV LNETQFSAFR GQECIFSKVS
110 120 130 140 150
GGPQGADLSV YAVTALPALC EPGDLLELLW LQPAPEPPAP APHWAVYVGG
160 170 180 190 200
GQIIHLHQGE IRQDSLYEAG AANVGRVVNS WYRYRPLVAE LVVQNACGHL
210 220 230 240 250
GLKSEEICWT NSESFAAWCR FGKREFKAGG EVPAGTQPPQ QQYYLKVHLG
260 270 280 290
ENKVHTARFH SLEDLIREKR RIDASGRLRV LQELADLVDD KE
Length:292
Mass (Da):32,491
Last modified:May 16, 2006 - v2
Checksum:i652F11029F517626
GO
Isoform 2 (identifier: Q96KN4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     146-292: VYVGGGQIIH...ELADLVDDKE → SRARRSAGRT...TWPSPRVHGQ

Show »
Length:354
Mass (Da):37,751
Checksum:iDF510D1FEEF93C1D
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti72 – 721H → Q in CAD10038 (Ref. 1) Curated
Sequence conflicti133 – 1331P → H in AAH26346 (PubMed:15815621).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei146 – 292147VYVGG…VDDKE → SRARRSAGRTRRASPPGAAL ASGSSRREGRCRQARSPRSS STISRCTWERTRSTPPGFTA WKTSSARSAVSTPAAACECS RSSPTSWTTRSSRLGAAGPS ASPAPRSLPFPAPGLRSQRF STSAPPRHARPPPVARARAA PPHPQASGRKSQELPQGRKG AAASAWLTATAVVTVLGDPA CAFPLRCKPGTGKGLRGERT WPSPRVHGQ in isoform 2. 1 PublicationVSP_018314Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ417080 mRNA. Translation: CAD10038.1.
AK092654 mRNA. Translation: BAC03938.1.
AC011897 Genomic DNA. Translation: AAY15041.1.
CH471053 Genomic DNA. Translation: EAX00905.1.
BC026346 mRNA. Translation: AAH26346.1.
BC052284 mRNA. Translation: AAH52284.1.
CCDSiCCDS1684.1. [Q96KN4-1]
RefSeqiNP_660158.2. NM_145175.2. [Q96KN4-1]
UniGeneiHs.260855.

Genome annotation databases

EnsembliENST00000295092; ENSP00000295092; ENSG00000162981. [Q96KN4-1]
ENST00000331243; ENSP00000330681; ENSG00000162981. [Q96KN4-1]
GeneIDi151354.
KEGGihsa:151354.
UCSCiuc002rbz.3. human. [Q96KN4-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ417080 mRNA. Translation: CAD10038.1.
AK092654 mRNA. Translation: BAC03938.1.
AC011897 Genomic DNA. Translation: AAY15041.1.
CH471053 Genomic DNA. Translation: EAX00905.1.
BC026346 mRNA. Translation: AAH26346.1.
BC052284 mRNA. Translation: AAH52284.1.
CCDSiCCDS1684.1. [Q96KN4-1]
RefSeqiNP_660158.2. NM_145175.2. [Q96KN4-1]
UniGeneiHs.260855.

3D structure databases

ProteinModelPortaliQ96KN4.
SMRiQ96KN4. Positions 118-224.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127371. 1 interaction.
IntActiQ96KN4. 1 interaction.
STRINGi9606.ENSP00000295092.

PTM databases

iPTMnetiQ96KN4.
PhosphoSiteiQ96KN4.

Polymorphism and mutation databases

BioMutaiFAM84A.
DMDMi97049335.

Proteomic databases

MaxQBiQ96KN4.
PaxDbiQ96KN4.
PeptideAtlasiQ96KN4.
PRIDEiQ96KN4.

Protocols and materials databases

DNASUi151354.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000295092; ENSP00000295092; ENSG00000162981. [Q96KN4-1]
ENST00000331243; ENSP00000330681; ENSG00000162981. [Q96KN4-1]
GeneIDi151354.
KEGGihsa:151354.
UCSCiuc002rbz.3. human. [Q96KN4-1]

Organism-specific databases

CTDi151354.
GeneCardsiFAM84A.
H-InvDBHIX0001836.
HGNCiHGNC:20743. FAM84A.
HPAiHPA047703.
MIMi611234. gene.
neXtProtiNX_Q96KN4.
PharmGKBiPA142671854.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IJCX. Eukaryota.
ENOG4111FA5. LUCA.
GeneTreeiENSGT00390000013755.
HOGENOMiHOG000293400.
HOVERGENiHBG054465.
InParanoidiQ96KN4.
OMAiCIFSKLR.
OrthoDBiEOG7HXCRJ.
PhylomeDBiQ96KN4.
TreeFamiTF330836.

Miscellaneous databases

ChiTaRSiFAM84A. human.
GenomeRNAii151354.
PROiQ96KN4.
SOURCEiSearch...

Gene expression databases

BgeeiQ96KN4.
CleanExiHS_FAM84A.
GenevisibleiQ96KN4. HS.

Family and domain databases

InterProiIPR007053. LRAT-like_dom.
[Graphical view]
PfamiPF04970. LRAT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of a novel member of the H-rev107 protein family."
    Hughes P.J., Stanway G.
    Submitted (OCT-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Prostate.
  3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiFA84A_HUMAN
AccessioniPrimary (citable) accession number: Q96KN4
Secondary accession number(s): A6NP76
, Q86UZ2, Q8NAH7, Q8TAM5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: May 16, 2006
Last modified: July 6, 2016
This is version 90 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.