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Protein

Homeobox protein PKNOX2

Gene

PKNOX2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Caution

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi291 – 350HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

Keywordsi

Molecular functionDNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein PKNOX2
Alternative name(s):
Homeobox protein PREP-2
PBX/knotted homeobox 2
Gene namesi
Name:PKNOX2
Synonyms:PREP2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000165495.15
HGNCiHGNC:16714 PKNOX2
MIMi613066 gene
neXtProtiNX_Q96KN3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi63876
OpenTargetsiENSG00000165495
PharmGKBiPA33355

Polymorphism and mutation databases

BioMutaiPKNOX2
DMDMi115311621

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000492501 – 472Homeobox protein PKNOX2Add BLAST472

Proteomic databases

MaxQBiQ96KN3
PaxDbiQ96KN3
PeptideAtlasiQ96KN3
PRIDEiQ96KN3

PTM databases

iPTMnetiQ96KN3
PhosphoSitePlusiQ96KN3

Expressioni

Gene expression databases

BgeeiENSG00000165495
CleanExiHS_PKNOX2
ExpressionAtlasiQ96KN3 baseline and differential
GenevisibleiQ96KN3 HS

Organism-specific databases

HPAiCAB034342
HPA028867
HPA055368
HPA066962

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi1219696 interactors.
IntActiQ96KN3 30 interactors.
STRINGi9606.ENSP00000298282

Structurei

3D structure databases

ProteinModelPortaliQ96KN3
SMRiQ96KN3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi20 – 23Poly-Pro4
Compositional biasi426 – 454Asp/Glu-rich (acidic)Add BLAST29

Sequence similaritiesi

Belongs to the TALE/MEIS homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0773 Eukaryota
ENOG410XPMQ LUCA
GeneTreeiENSGT00550000074260
HOGENOMiHOG000253922
HOVERGENiHBG055193
InParanoidiQ96KN3
OMAiTMMATQS
OrthoDBiEOG091G09WJ
PhylomeDBiQ96KN3
TreeFamiTF318093

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR001356 Homeobox_dom
IPR008422 Homeobox_KN_domain
IPR032453 PKNOX/Meis_N
PfamiView protein in Pfam
PF05920 Homeobox_KN, 1 hit
PF16493 Meis_PKNOX_N, 1 hit
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS50071 HOMEOBOX_2, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96KN3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MMQHASPAPA LTMMATQNVP PPPYQDSPQM TATAQPPSKA QAVHISAPSA
60 70 80 90 100
AASTPVPSAP IDPQAQLEAD KRAVYRHPLF PLLTLLFEKC EQATQGSECI
110 120 130 140 150
TSASFDVDIE NFVHQQEQEH KPFFSDDPEL DNLMVKAIQV LRIHLLELEK
160 170 180 190 200
VNELCKDFCN RYITCLKTKM HSDNLLRNDL GGPYSPNQPS INLHSQDLLQ
210 220 230 240 250
NSPNSMSGVS NNPQGIVVPA SALQQGNIAM TTVNSQVVSG GALYQPVTMV
260 270 280 290 300
TSQGQVVTQA IPQGAIQIQN TQVNLDLTSL LDNEDKKSKN KRGVLPKHAT
310 320 330 340 350
NIMRSWLFQH LMHPYPTEDE KRQIAAQTNL TLLQVNNWFI NARRRILQPM
360 370 380 390 400
LDASNPDPAP KAKKIKSQHR PTQRFWPNSI AAGVLQQQGG APGTNPDGSI
410 420 430 440 450
NLDNLQSLSS DSATMAMQQA MMAAHDDSLD GTEEEDEDEM EEEEEEELEE
460 470
EVDELQTTNV SDLGLEHSDS LE
Length:472
Mass (Da):52,028
Last modified:September 19, 2006 - v2
Checksum:iC83EBE0DA3F286E8
GO
Isoform 2 (identifier: Q96KN3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-75: MMQHASPAPA...QLEADKRAVY → MSRPHPTRTAH

Note: No experimental confirmation available.
Show »
Length:408
Mass (Da):45,557
Checksum:i5B385026F493D452
GO

Sequence cautioni

The sequence BAB83665 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti427D → G in BAH12921 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_049590110E → K. Corresponds to variant dbSNP:rs34936365Ensembl.1
Natural variantiVAR_027500447Missing 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0543061 – 75MMQHA…KRAVY → MSRPHPTRTAH in isoform 2. 1 PublicationAdd BLAST75

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK298999 mRNA Translation: BAH12921.1
BX648615 mRNA Translation: CAH56146.1
AP000708 Genomic DNA No translation available.
AP001007 Genomic DNA No translation available.
AP003061 Genomic DNA No translation available.
AP003069 Genomic DNA No translation available.
BC045626 mRNA Translation: AAH45626.3
AB065001 mRNA Translation: BAB83665.1 Different initiation.
AJ417081 mRNA Translation: CAD01142.1
CCDSiCCDS41730.1 [Q96KN3-1]
PIRiJC7766
RefSeqiNP_071345.2, NM_022062.2 [Q96KN3-1]
XP_005271699.1, XM_005271642.2 [Q96KN3-1]
XP_011541246.1, XM_011542944.2 [Q96KN3-1]
XP_011541247.1, XM_011542945.2 [Q96KN3-1]
XP_016873599.1, XM_017018110.1 [Q96KN3-1]
UniGeneiHs.278564

Genome annotation databases

EnsembliENST00000298282; ENSP00000298282; ENSG00000165495 [Q96KN3-1]
GeneIDi63876
KEGGihsa:63876
UCSCiuc001qbu.4 human [Q96KN3-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiPKNX2_HUMAN
AccessioniPrimary (citable) accession number: Q96KN3
Secondary accession number(s): B7Z5I5
, F5GZ15, Q63HL6, Q86XD1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2002
Last sequence update: September 19, 2006
Last modified: March 28, 2018
This is version 134 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome