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Protein

Protein FAM84B

Gene

FAM84B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Protein FAM84B
Alternative name(s):
Breast cancer membrane protein 101
Protein NSE2
Gene namesi
Name:FAM84B
Synonyms:BCMP101, NSE2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:24166. FAM84B.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: HGNC
  • plasma membrane Source: HGNC
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142671855.

Polymorphism and mutation databases

BioMutaiFAM84B.
DMDMi74732219.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 310310Protein FAM84BPRO_0000234348Add
BLAST

Proteomic databases

EPDiQ96KN1.
MaxQBiQ96KN1.
PaxDbiQ96KN1.
PeptideAtlasiQ96KN1.
PRIDEiQ96KN1.

PTM databases

iPTMnetiQ96KN1.
PhosphoSiteiQ96KN1.

Expressioni

Tissue specificityi

Expressed in esophageal squamous cell carcinomas.1 Publication

Gene expression databases

BgeeiQ96KN1.
CleanExiHS_FAM84B.
GenevisibleiQ96KN1. HS.

Organism-specific databases

HPAiHPA050782.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CHEK2O960173EBI-9057780,EBI-1180783
RAD51Q066094EBI-9057780,EBI-297202
URODP061323EBI-9057780,EBI-2871776

Protein-protein interaction databases

BioGridi127609. 19 interactions.
IntActiQ96KN1. 11 interactions.
STRINGi9606.ENSP00000302578.

Structurei

3D structure databases

ProteinModelPortaliQ96KN1.
SMRiQ96KN1. Positions 117-211.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi47 – 7630Pro-richAdd
BLAST

Sequence similaritiesi

Belongs to the FAM84 family.Curated

Phylogenomic databases

eggNOGiENOG410IGIG. Eukaryota.
ENOG410ZUU0. LUCA.
GeneTreeiENSGT00390000013755.
HOGENOMiHOG000293400.
HOVERGENiHBG054465.
InParanoidiQ96KN1.
OMAiYYRDECI.
OrthoDBiEOG7HXCRJ.
PhylomeDBiQ96KN1.
TreeFamiTF330836.

Family and domain databases

InterProiIPR028815. FAM84B.
IPR007053. LRAT-like_dom.
[Graphical view]
PANTHERiPTHR13943:SF39. PTHR13943:SF39. 1 hit.
PfamiPF04970. LRAT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96KN1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGNQVEKLTH LSYKEVPTAD PTGVDRDDGP RIGVSYIFSN DDEDVEPQPP
60 70 80 90 100
PQGPDGGGLP DGGDGPPPPQ PQPYDPRLHE VECSVFYRDE CIYQKSFAPG
110 120 130 140 150
SAALSTYTPE NLLNKCKPGD LVEFVSQAQY PHWAVYVGNF QVVHLHRLEV
160 170 180 190 200
INSFLTDASQ GRRGRVVNDL YRYKPLSSSA VVRNALAHVG AKERELSWRN
210 220 230 240 250
SESFAAWCRY GKREFKIGGE LRIGKQPYRL QIQLSAQRSH TLEFQSLEDL
260 270 280 290 300
IMEKRRNDQI GRAAVLQELA THLHPAEPEE GDSNVARTTP PPGRPPAPSS
310
EEEDGEAVAH
Length:310
Mass (Da):34,474
Last modified:December 1, 2001 - v1
Checksum:iB587A33F9CB41938
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ417849 mRNA. Translation: CAD10629.1.
BC052957 mRNA. Translation: AAH52957.1.
CCDSiCCDS6358.1.
RefSeqiNP_777571.1. NM_174911.4.
UniGeneiHs.741352.

Genome annotation databases

EnsembliENST00000304916; ENSP00000302578; ENSG00000168672.
GeneIDi157638.
KEGGihsa:157638.
UCSCiuc003yrz.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ417849 mRNA. Translation: CAD10629.1.
BC052957 mRNA. Translation: AAH52957.1.
CCDSiCCDS6358.1.
RefSeqiNP_777571.1. NM_174911.4.
UniGeneiHs.741352.

3D structure databases

ProteinModelPortaliQ96KN1.
SMRiQ96KN1. Positions 117-211.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127609. 19 interactions.
IntActiQ96KN1. 11 interactions.
STRINGi9606.ENSP00000302578.

PTM databases

iPTMnetiQ96KN1.
PhosphoSiteiQ96KN1.

Polymorphism and mutation databases

BioMutaiFAM84B.
DMDMi74732219.

Proteomic databases

EPDiQ96KN1.
MaxQBiQ96KN1.
PaxDbiQ96KN1.
PeptideAtlasiQ96KN1.
PRIDEiQ96KN1.

Protocols and materials databases

DNASUi157638.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000304916; ENSP00000302578; ENSG00000168672.
GeneIDi157638.
KEGGihsa:157638.
UCSCiuc003yrz.3. human.

Organism-specific databases

CTDi157638.
GeneCardsiFAM84B.
HGNCiHGNC:24166. FAM84B.
HPAiHPA050782.
MIMi609483. gene.
neXtProtiNX_Q96KN1.
PharmGKBiPA142671855.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IGIG. Eukaryota.
ENOG410ZUU0. LUCA.
GeneTreeiENSGT00390000013755.
HOGENOMiHOG000293400.
HOVERGENiHBG054465.
InParanoidiQ96KN1.
OMAiYYRDECI.
OrthoDBiEOG7HXCRJ.
PhylomeDBiQ96KN1.
TreeFamiTF330836.

Miscellaneous databases

GenomeRNAii157638.
PROiQ96KN1.
SOURCEiSearch...

Gene expression databases

BgeeiQ96KN1.
CleanExiHS_FAM84B.
GenevisibleiQ96KN1. HS.

Family and domain databases

InterProiIPR028815. FAM84B.
IPR007053. LRAT-like_dom.
[Graphical view]
PANTHERiPTHR13943:SF39. PTHR13943:SF39. 1 hit.
PfamiPF04970. LRAT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A novel NS-containing protein."
    Hughes P.J., Stanway G.
    Submitted (OCT-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  3. Cited for: TISSUE SPECIFICITY.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiFA84B_HUMAN
AccessioniPrimary (citable) accession number: Q96KN1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: December 1, 2001
Last modified: July 6, 2016
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.