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Q96KM6

- Z512B_HUMAN

UniProt

Q96KM6 - Z512B_HUMAN

Protein

Zinc finger protein 512B

Gene

ZNF512B

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 114 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    May be involved in transcriptional regulation.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri105 – 12925C2H2-type 1; atypicalPROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri140 – 16324C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri540 – 56324C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri594 – 61825C2H2-type 4; atypicalPROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri630 – 65324C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri750 – 77425C2H2-type 6; atypicalPROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri784 – 80724C2H2-type 7PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. regulation of transcription, DNA-templated Source: UniProtKB-KW
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Zinc finger protein 512B
    Gene namesi
    Name:ZNF512B
    Synonyms:KIAA1196
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 20

    Organism-specific databases

    HGNCiHGNC:29212. ZNF512B.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA162410181.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 892892Zinc finger protein 512BPRO_0000047779Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei409 – 4091Phosphoserine1 Publication
    Modified residuei686 – 6861Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ96KM6.
    PaxDbiQ96KM6.
    PRIDEiQ96KM6.

    PTM databases

    PhosphoSiteiQ96KM6.

    Expressioni

    Gene expression databases

    BgeeiQ96KM6.
    CleanExiHS_ZNF512B.
    GenevestigatoriQ96KM6.

    Organism-specific databases

    HPAiHPA006688.

    Interactioni

    Protein-protein interaction databases

    BioGridi121543. 60 interactions.
    IntActiQ96KM6. 59 interactions.
    MINTiMINT-1180628.

    Structurei

    Secondary structure

    1
    892
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi499 – 5024
    Turni503 – 5075
    Turni513 – 5153
    Helixi524 – 54017
    Beta strandi543 – 5453
    Helixi552 – 56211

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2GQJNMR-A493-577[»]
    ProteinModelPortaliQ96KM6.
    SMRiQ96KM6. Positions 497-577, 588-662, 741-815.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ96KM6.

    Family & Domainsi

    Sequence similaritiesi

    Contains 7 C2H2-type zinc fingers.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri105 – 12925C2H2-type 1; atypicalPROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri140 – 16324C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri540 – 56324C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri594 – 61825C2H2-type 4; atypicalPROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri630 – 65324C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri750 – 77425C2H2-type 6; atypicalPROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri784 – 80724C2H2-type 7PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiNOG235851.
    HOGENOMiHOG000070202.
    HOVERGENiHBG081832.
    InParanoidiQ96KM6.
    OMAiISRHTPP.
    OrthoDBiEOG7T1R9K.
    PhylomeDBiQ96KM6.
    TreeFamiTF331185.

    Family and domain databases

    InterProiIPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    [Graphical view]
    SMARTiSM00355. ZnF_C2H2. 6 hits.
    [Graphical view]
    PROSITEiPS00028. ZINC_FINGER_C2H2_1. 4 hits.
    PS50157. ZINC_FINGER_C2H2_2. 4 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q96KM6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTDPFCVGGR RLPGSSKSGP GKDGSRKEVR LPMLHDPPKM GMPVVRGGQT    50
    VPGQAPLCFD PGSPASDKTE GKKKGRPKAE NQALRDIPLS LMNDWKDEFK 100
    AHSRVKCPNS GCWLEFPSIY GLKYHYQRCQ GGAISDRLAF PCPFCEAAFT 150
    SKTQLEKHRI WNHMDRPLPA SKPGPISRPV TISRPVGVSK PIGVSKPVTI 200
    GKPVGVSKPI GISKPVSVGR PMPVTKAIPV TRPVPVTKPV TVSRPMPVTK 250
    AMPVTKPITV TKSVPVTKPV PVTKPITVTK LVTVTKPVPV TKPVTVSRPI 300
    VVSKPVTVSR PIAISRHTPP CKMVLLTRSE NKAPRATGRN SGKKRAADSL 350
    DTCPIPPKQA RPENGEYGPS SMGQSSAFQL SADTSSGSLS PGSRPSGGME 400
    ALKAAGPASP PEEDPERTKH RRKQKTPKKF TGEQPSISGT FGLKGLVKAE 450
    DKARVHRSKK QEGPGPEDAR KKVPAAPITV SKEAPAPVAH PAPGGPEEQW 500
    QRAIHERGEA VCPTCNVVTR KTLVGLKKHM EVCQKLQDAL KCQHCRKQFK 550
    SKAGLNYHTM AEHSAKPSDA EASEGGEQEE RERLRKVLKQ MGRLRCPQEG 600
    CGAAFSSLMG YQYHQRRCGK PPCEVDSPSF PCTHCGKTYR SKAGHDYHVR 650
    SEHTAPPPEE PTDKSPEAED PLGVERTPSG RVRRTSAQVA VFHLQEIAED 700
    ELARDWTKRR MKDDLVPETA RLNYTRPGLP TLNPQLLEAW KNEVKEKGHV 750
    NCPNDCCEAI YSSVSGLKAH LASCSKGAHL AGKYRCLLCP KEFSSESGVK 800
    YHILKTHAEN WFRTSADPPP KHRSQDSLVP KKEKKKNLAG GKKRGRKPKE 850
    RTPEEPVAKL PPRRDDWPPG CRDKGARGST GRKVGVSKAP EK 892
    Length:892
    Mass (Da):97,264
    Last modified:December 1, 2001 - v1
    Checksum:i50449C476DFCE4DF
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti288 – 2881V → M.
    Corresponds to variant rs45486695 [ dbSNP | Ensembl ].
    VAR_061954
    Natural varianti372 – 3721M → V.
    Corresponds to variant rs817326 [ dbSNP | Ensembl ].
    VAR_024226
    Natural varianti453 – 4531A → T.
    Corresponds to variant rs6062599 [ dbSNP | Ensembl ].
    VAR_024227

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL118506 Genomic DNA. Translation: CAC15498.3.
    BC125128 mRNA. Translation: AAI25129.1.
    BC125129 mRNA. Translation: AAI25130.1.
    AB033022 mRNA. Translation: BAA86510.1.
    AL834525 mRNA. Translation: CAD39181.1.
    CCDSiCCDS13548.1.
    RefSeqiNP_065764.1. NM_020713.2.
    UniGeneiHs.740578.

    Genome annotation databases

    EnsembliENST00000217130; ENSP00000217130; ENSG00000196700.
    ENST00000369888; ENSP00000358904; ENSG00000196700.
    ENST00000450537; ENSP00000393795; ENSG00000196700.
    GeneIDi57473.
    KEGGihsa:57473.
    UCSCiuc002yhl.2. human.

    Polymorphism databases

    DMDMi23822331.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL118506 Genomic DNA. Translation: CAC15498.3 .
    BC125128 mRNA. Translation: AAI25129.1 .
    BC125129 mRNA. Translation: AAI25130.1 .
    AB033022 mRNA. Translation: BAA86510.1 .
    AL834525 mRNA. Translation: CAD39181.1 .
    CCDSi CCDS13548.1.
    RefSeqi NP_065764.1. NM_020713.2.
    UniGenei Hs.740578.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2GQJ NMR - A 493-577 [» ]
    ProteinModelPortali Q96KM6.
    SMRi Q96KM6. Positions 497-577, 588-662, 741-815.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 121543. 60 interactions.
    IntActi Q96KM6. 59 interactions.
    MINTi MINT-1180628.

    PTM databases

    PhosphoSitei Q96KM6.

    Polymorphism databases

    DMDMi 23822331.

    Proteomic databases

    MaxQBi Q96KM6.
    PaxDbi Q96KM6.
    PRIDEi Q96KM6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000217130 ; ENSP00000217130 ; ENSG00000196700 .
    ENST00000369888 ; ENSP00000358904 ; ENSG00000196700 .
    ENST00000450537 ; ENSP00000393795 ; ENSG00000196700 .
    GeneIDi 57473.
    KEGGi hsa:57473.
    UCSCi uc002yhl.2. human.

    Organism-specific databases

    CTDi 57473.
    GeneCardsi GC20M062588.
    HGNCi HGNC:29212. ZNF512B.
    HPAi HPA006688.
    neXtProti NX_Q96KM6.
    PharmGKBi PA162410181.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG235851.
    HOGENOMi HOG000070202.
    HOVERGENi HBG081832.
    InParanoidi Q96KM6.
    OMAi ISRHTPP.
    OrthoDBi EOG7T1R9K.
    PhylomeDBi Q96KM6.
    TreeFami TF331185.

    Miscellaneous databases

    EvolutionaryTracei Q96KM6.
    GenomeRNAii 57473.
    NextBioi 63707.
    PROi Q96KM6.

    Gene expression databases

    Bgeei Q96KM6.
    CleanExi HS_ZNF512B.
    Genevestigatori Q96KM6.

    Family and domain databases

    InterProi IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    [Graphical view ]
    SMARTi SM00355. ZnF_C2H2. 6 hits.
    [Graphical view ]
    PROSITEi PS00028. ZINC_FINGER_C2H2_1. 4 hits.
    PS50157. ZINC_FINGER_C2H2_2. 4 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The DNA sequence and comparative analysis of human chromosome 20."
      Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
      , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
      Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    3. "Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
      Nagase T., Ishikawa K., Kikuno R., Hirosawa M., Nomura N., Ohara O.
      DNA Res. 6:337-345(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 42-892.
      Tissue: Brain.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 425-892.
      Tissue: Testis.
    5. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
      Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
      Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-409, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    6. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-686, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    7. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    8. "Solution structure of the two ZF-C2H2-like domains (493-575) of human zinc finger protein KIAA1196."
      RIKEN structural genomics initiative (RSGI)
      Submitted (OCT-2006) to the PDB data bank
      Cited for: STRUCTURE BY NMR OF 493-577.

    Entry informationi

    Entry nameiZ512B_HUMAN
    AccessioniPrimary (citable) accession number: Q96KM6
    Secondary accession number(s): Q08AK9, Q9ULM4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 10, 2002
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 114 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 20
      Human chromosome 20: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3