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Q96KM6

- Z512B_HUMAN

UniProt

Q96KM6 - Z512B_HUMAN

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Protein
Zinc finger protein 512B
Gene
ZNF512B, KIAA1196
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri105 – 12925C2H2-type 1; atypical
Add
BLAST
Zinc fingeri140 – 16324C2H2-type 2
Add
BLAST
Zinc fingeri540 – 56324C2H2-type 3
Add
BLAST
Zinc fingeri594 – 61825C2H2-type 4; atypical
Add
BLAST
Zinc fingeri630 – 65324C2H2-type 5
Add
BLAST
Zinc fingeri750 – 77425C2H2-type 6; atypical
Add
BLAST
Zinc fingeri784 – 80724C2H2-type 7
Add
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
Complete GO annotation...

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 512B
Gene namesi
Name:ZNF512B
Synonyms:KIAA1196
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 20

Organism-specific databases

HGNCiHGNC:29212. ZNF512B.

Subcellular locationi

Nucleus Inferred

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162410181.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 892892Zinc finger protein 512B
PRO_0000047779Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei409 – 4091Phosphoserine1 Publication
Modified residuei686 – 6861Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ96KM6.
PaxDbiQ96KM6.
PRIDEiQ96KM6.

PTM databases

PhosphoSiteiQ96KM6.

Expressioni

Gene expression databases

BgeeiQ96KM6.
CleanExiHS_ZNF512B.
GenevestigatoriQ96KM6.

Organism-specific databases

HPAiHPA006688.

Interactioni

Protein-protein interaction databases

BioGridi121543. 59 interactions.
IntActiQ96KM6. 59 interactions.
MINTiMINT-1180628.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi499 – 5024
Turni503 – 5075
Turni513 – 5153
Helixi524 – 54017
Beta strandi543 – 5453
Helixi552 – 56211

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2GQJNMR-A493-577[»]
ProteinModelPortaliQ96KM6.
SMRiQ96KM6. Positions 497-577, 588-662, 741-815.

Miscellaneous databases

EvolutionaryTraceiQ96KM6.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiNOG235851.
HOGENOMiHOG000070202.
HOVERGENiHBG081832.
InParanoidiQ96KM6.
OMAiISRHTPP.
OrthoDBiEOG7T1R9K.
PhylomeDBiQ96KM6.
TreeFamiTF331185.

Family and domain databases

InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 6 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 4 hits.
PS50157. ZINC_FINGER_C2H2_2. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96KM6-1 [UniParc]FASTAAdd to Basket

« Hide

MTDPFCVGGR RLPGSSKSGP GKDGSRKEVR LPMLHDPPKM GMPVVRGGQT    50
VPGQAPLCFD PGSPASDKTE GKKKGRPKAE NQALRDIPLS LMNDWKDEFK 100
AHSRVKCPNS GCWLEFPSIY GLKYHYQRCQ GGAISDRLAF PCPFCEAAFT 150
SKTQLEKHRI WNHMDRPLPA SKPGPISRPV TISRPVGVSK PIGVSKPVTI 200
GKPVGVSKPI GISKPVSVGR PMPVTKAIPV TRPVPVTKPV TVSRPMPVTK 250
AMPVTKPITV TKSVPVTKPV PVTKPITVTK LVTVTKPVPV TKPVTVSRPI 300
VVSKPVTVSR PIAISRHTPP CKMVLLTRSE NKAPRATGRN SGKKRAADSL 350
DTCPIPPKQA RPENGEYGPS SMGQSSAFQL SADTSSGSLS PGSRPSGGME 400
ALKAAGPASP PEEDPERTKH RRKQKTPKKF TGEQPSISGT FGLKGLVKAE 450
DKARVHRSKK QEGPGPEDAR KKVPAAPITV SKEAPAPVAH PAPGGPEEQW 500
QRAIHERGEA VCPTCNVVTR KTLVGLKKHM EVCQKLQDAL KCQHCRKQFK 550
SKAGLNYHTM AEHSAKPSDA EASEGGEQEE RERLRKVLKQ MGRLRCPQEG 600
CGAAFSSLMG YQYHQRRCGK PPCEVDSPSF PCTHCGKTYR SKAGHDYHVR 650
SEHTAPPPEE PTDKSPEAED PLGVERTPSG RVRRTSAQVA VFHLQEIAED 700
ELARDWTKRR MKDDLVPETA RLNYTRPGLP TLNPQLLEAW KNEVKEKGHV 750
NCPNDCCEAI YSSVSGLKAH LASCSKGAHL AGKYRCLLCP KEFSSESGVK 800
YHILKTHAEN WFRTSADPPP KHRSQDSLVP KKEKKKNLAG GKKRGRKPKE 850
RTPEEPVAKL PPRRDDWPPG CRDKGARGST GRKVGVSKAP EK 892
Length:892
Mass (Da):97,264
Last modified:December 1, 2001 - v1
Checksum:i50449C476DFCE4DF
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti288 – 2881V → M.
Corresponds to variant rs45486695 [ dbSNP | Ensembl ].
VAR_061954
Natural varianti372 – 3721M → V.
Corresponds to variant rs817326 [ dbSNP | Ensembl ].
VAR_024226
Natural varianti453 – 4531A → T.
Corresponds to variant rs6062599 [ dbSNP | Ensembl ].
VAR_024227

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL118506 Genomic DNA. Translation: CAC15498.3.
BC125128 mRNA. Translation: AAI25129.1.
BC125129 mRNA. Translation: AAI25130.1.
AB033022 mRNA. Translation: BAA86510.1.
AL834525 mRNA. Translation: CAD39181.1.
CCDSiCCDS13548.1.
RefSeqiNP_065764.1. NM_020713.2.
UniGeneiHs.740578.

Genome annotation databases

EnsembliENST00000217130; ENSP00000217130; ENSG00000196700.
ENST00000369888; ENSP00000358904; ENSG00000196700.
ENST00000450537; ENSP00000393795; ENSG00000196700.
GeneIDi57473.
KEGGihsa:57473.
UCSCiuc002yhl.2. human.

Polymorphism databases

DMDMi23822331.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL118506 Genomic DNA. Translation: CAC15498.3 .
BC125128 mRNA. Translation: AAI25129.1 .
BC125129 mRNA. Translation: AAI25130.1 .
AB033022 mRNA. Translation: BAA86510.1 .
AL834525 mRNA. Translation: CAD39181.1 .
CCDSi CCDS13548.1.
RefSeqi NP_065764.1. NM_020713.2.
UniGenei Hs.740578.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2GQJ NMR - A 493-577 [» ]
ProteinModelPortali Q96KM6.
SMRi Q96KM6. Positions 497-577, 588-662, 741-815.
ModBasei Search...

Protein-protein interaction databases

BioGridi 121543. 59 interactions.
IntActi Q96KM6. 59 interactions.
MINTi MINT-1180628.

PTM databases

PhosphoSitei Q96KM6.

Polymorphism databases

DMDMi 23822331.

Proteomic databases

MaxQBi Q96KM6.
PaxDbi Q96KM6.
PRIDEi Q96KM6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000217130 ; ENSP00000217130 ; ENSG00000196700 .
ENST00000369888 ; ENSP00000358904 ; ENSG00000196700 .
ENST00000450537 ; ENSP00000393795 ; ENSG00000196700 .
GeneIDi 57473.
KEGGi hsa:57473.
UCSCi uc002yhl.2. human.

Organism-specific databases

CTDi 57473.
GeneCardsi GC20M062588.
HGNCi HGNC:29212. ZNF512B.
HPAi HPA006688.
neXtProti NX_Q96KM6.
PharmGKBi PA162410181.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG235851.
HOGENOMi HOG000070202.
HOVERGENi HBG081832.
InParanoidi Q96KM6.
OMAi ISRHTPP.
OrthoDBi EOG7T1R9K.
PhylomeDBi Q96KM6.
TreeFami TF331185.

Miscellaneous databases

EvolutionaryTracei Q96KM6.
GenomeRNAii 57473.
NextBioi 63707.
PROi Q96KM6.

Gene expression databases

Bgeei Q96KM6.
CleanExi HS_ZNF512B.
Genevestigatori Q96KM6.

Family and domain databases

InterProi IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
[Graphical view ]
SMARTi SM00355. ZnF_C2H2. 6 hits.
[Graphical view ]
PROSITEi PS00028. ZINC_FINGER_C2H2_1. 4 hits.
PS50157. ZINC_FINGER_C2H2_2. 4 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence and comparative analysis of human chromosome 20."
    Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
    , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
    Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Ishikawa K., Kikuno R., Hirosawa M., Nomura N., Ohara O.
    DNA Res. 6:337-345(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 42-892.
    Tissue: Brain.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 425-892.
    Tissue: Testis.
  5. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
    Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
    Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-409, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  6. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-686, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  7. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  8. "Solution structure of the two ZF-C2H2-like domains (493-575) of human zinc finger protein KIAA1196."
    RIKEN structural genomics initiative (RSGI)
    Submitted (OCT-2006) to the PDB data bank
    Cited for: STRUCTURE BY NMR OF 493-577.

Entry informationi

Entry nameiZ512B_HUMAN
AccessioniPrimary (citable) accession number: Q96KM6
Secondary accession number(s): Q08AK9, Q9ULM4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: December 1, 2001
Last modified: July 9, 2014
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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