ID   O10C1_HUMAN             Reviewed;         312 AA.
AC   Q96KK4; Q5SUN7; Q96R18;
DT   23-JAN-2002, integrated into UniProtKB/Swiss-Prot.
DT   18-MAY-2010, sequence version 3.
DT   27-MAR-2024, entry version 183.
DE   RecName: Full=Olfactory receptor 10C1;
DE   AltName: Full=Hs6M1-17;
DE   AltName: Full=Olfactory receptor 10C2;
GN   Name=OR10C1; Synonyms=OR10C2;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANT VAL-246.
RX   PubMed=14574404; DOI=10.1038/nature02055;
RA   Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA   Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R.,
RA   Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D.,
RA   Andrews T.D., Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J.,
RA   Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H.,
RA   Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J.,
RA   Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA   Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA   Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA   Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E.,
RA   Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J.,
RA   French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J.,
RA   Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C.,
RA   Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A.,
RA   Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R.,
RA   Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M.,
RA   Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K.,
RA   Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R.,
RA   Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA   Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A.,
RA   Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L.,
RA   Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I.,
RA   Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y.,
RA   Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E.,
RA   Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A.,
RA   Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W.,
RA   Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M.,
RA   West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J.,
RA   Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M.,
RA   Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I.,
RA   Rogers J., Beck S.;
RT   "The DNA sequence and analysis of human chromosome 6.";
RL   Nature 425:805-811(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 67-282, AND VARIANT VAL-246.
RX   PubMed=12213199; DOI=10.1006/geno.2002.6830;
RA   Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R.,
RA   Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U.,
RA   Lehrach H., Lancet D., Shamir R.;
RT   "DEFOG: a practical scheme for deciphering families of genes.";
RL   Genomics 80:295-302(2002).
RN   [4]
RP   POLYMORPHISM.
RX   PubMed=12730696; DOI=10.1038/ng1160;
RA   Menashe I., Man O., Lancet D., Gilad Y.;
RT   "Different noses for different people.";
RL   Nat. Genet. 34:143-144(2003).
CC   -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- POLYMORPHISM: A stop codon at position Gln-55 in the gene coding for
CC       this protein is responsible for functional diversity thus producing a
CC       pseudogene. The stop codon is more frequent in African-Americans than
CC       in non-Africans.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAB44507.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC   -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC       URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR10C2";
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DR   EMBL; AL035542; CAB44507.1; ALT_INIT; Genomic_DNA.
DR   EMBL; AL645927; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CR759768; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CR388393; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC136996; AAI36997.1; -; mRNA.
DR   EMBL; BC136997; AAI36998.1; -; mRNA.
DR   EMBL; AF399627; AAK95112.1; -; Genomic_DNA.
DR   CCDS; CCDS34364.1; -.
DR   RefSeq; NP_039229.3; NM_013941.3.
DR   AlphaFoldDB; Q96KK4; -.
DR   SMR; Q96KK4; -.
DR   STRING; 9606.ENSP00000419119; -.
DR   GlyCosmos; Q96KK4; 1 site, No reported glycans.
DR   GlyGen; Q96KK4; 1 site.
DR   iPTMnet; Q96KK4; -.
DR   PhosphoSitePlus; Q96KK4; -.
DR   BioMuta; OR10C1; -.
DR   DMDM; 296439284; -.
DR   MassIVE; Q96KK4; -.
DR   PaxDb; 9606-ENSP00000485032; -.
DR   PeptideAtlas; Q96KK4; -.
DR   Antibodypedia; 57682; 59 antibodies from 18 providers.
DR   DNASU; 442194; -.
DR   Ensembl; ENST00000377138.1; ENSP00000366343.1; ENSG00000229412.5.
DR   Ensembl; ENST00000391549.2; ENSP00000375393.2; ENSG00000204689.7.
DR   Ensembl; ENST00000437403.1; ENSP00000408961.1; ENSG00000224234.5.
DR   Ensembl; ENST00000444197.3; ENSP00000419119.1; ENSG00000206474.8.
DR   Ensembl; ENST00000455234.1; ENSP00000402486.1; ENSG00000230505.4.
DR   Ensembl; ENST00000457403.1; ENSP00000412512.1; ENSG00000232397.5.
DR   GeneID; 442194; -.
DR   KEGG; hsa:442194; -.
DR   MANE-Select; ENST00000444197.3; ENSP00000419119.1; NM_013941.4; NP_039229.3.
DR   UCSC; uc011dlp.3; human.
DR   AGR; HGNC:8165; -.
DR   CTD; 442194; -.
DR   GeneCards; OR10C1; -.
DR   HGNC; HGNC:8165; OR10C1.
DR   HPA; ENSG00000206474; Not detected.
DR   neXtProt; NX_Q96KK4; -.
DR   VEuPathDB; HostDB:ENSG00000206474; -.
DR   eggNOG; ENOG502QVH7; Eukaryota.
DR   GeneTree; ENSGT01050000244815; -.
DR   HOGENOM; CLU_012526_0_1_1; -.
DR   InParanoid; Q96KK4; -.
DR   OMA; SHRMCLQ; -.
DR   OrthoDB; 5305474at2759; -.
DR   PhylomeDB; Q96KK4; -.
DR   TreeFam; TF337350; -.
DR   PathwayCommons; Q96KK4; -.
DR   Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR   BioGRID-ORCS; 442194; 44 hits in 739 CRISPR screens.
DR   GeneWiki; OR10C1; -.
DR   GenomeRNAi; 442194; -.
DR   Pharos; Q96KK4; Tdark.
DR   PRO; PR:Q96KK4; -.
DR   Proteomes; UP000005640; Chromosome 6.
DR   RNAct; Q96KK4; Protein.
DR   Bgee; ENSG00000206474; Expressed in bone marrow cell.
DR   ExpressionAtlas; Q96KK4; baseline and differential.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR   GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR   GO; GO:0050911; P:detection of chemical stimulus involved in sensory perception of smell; IBA:GO_Central.
DR   CDD; cd15225; 7tmA_OR10A-like; 1.
DR   Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR000725; Olfact_rcpt.
DR   PANTHER; PTHR26453; OLFACTORY RECEPTOR; 1.
DR   PANTHER; PTHR26453:SF669; OLFACTORY RECEPTOR 10C1; 1.
DR   Pfam; PF13853; 7tm_4; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR00245; OLFACTORYR.
DR   SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
DR   Genevisible; Q96KK4; HS.
PE   2: Evidence at transcript level;
KW   Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW   Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW   Transducer; Transmembrane; Transmembrane helix.
FT   CHAIN           1..312
FT                   /note="Olfactory receptor 10C1"
FT                   /id="PRO_0000150693"
FT   TOPO_DOM        1..24
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        25..45
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        46..53
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        54..74
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        75..98
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        99..119
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        120..138
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        139..159
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        160..196
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        197..216
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        217..236
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        237..257
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        258..270
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        271..291
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        292..312
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        4
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        96..188
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT   VARIANT         57
FT                   /note="P -> S (in dbSNP:rs17184016)"
FT                   /id="VAR_037822"
FT   VARIANT         60
FT                   /note="F -> L (in dbSNP:rs2074469)"
FT                   /id="VAR_037823"
FT   VARIANT         89
FT                   /note="R -> S (in dbSNP:rs11755182)"
FT                   /id="VAR_037824"
FT   VARIANT         100
FT                   /note="M -> V (in dbSNP:rs17177632)"
FT                   /id="VAR_037825"
FT   VARIANT         121
FT                   /note="R -> C (in dbSNP:rs17177639)"
FT                   /id="VAR_037826"
FT   VARIANT         138
FT                   /note="R -> W (in dbSNP:rs17177646)"
FT                   /id="VAR_037827"
FT   VARIANT         160
FT                   /note="P -> S (in dbSNP:rs2074468)"
FT                   /id="VAR_037828"
FT   VARIANT         161
FT                   /note="F -> L (in dbSNP:rs2074467)"
FT                   /id="VAR_037829"
FT   VARIANT         174
FT                   /note="P -> Q (in dbSNP:rs2074466)"
FT                   /id="VAR_037830"
FT   VARIANT         246
FT                   /note="M -> V (in dbSNP:rs2074464)"
FT                   /evidence="ECO:0000269|PubMed:12213199,
FT                   ECO:0000269|PubMed:14574404"
FT                   /id="VAR_037831"
FT   VARIANT         255
FT                   /note="L -> I (in dbSNP:rs17177674)"
FT                   /id="VAR_037832"
FT   VARIANT         310
FT                   /note="M -> R (in dbSNP:rs11968123)"
FT                   /id="VAR_037833"
SQ   SEQUENCE   312 AA;  34384 MW;  B6FD7A4A2018F69C CRC64;
     MSANTSMVTE FLLLGFSHLA DLQGLLFSVF LTIYLLTVAG NFLIVVLVST DAALQSPMYF
     FLRTLSALEI GYTSVTVPLL LHHLLTGRRH ISRSGCALQM FFFLFFGATE CCLLAAMAYD
     RYAAICEPLR YPLLLSHRVC LQLAGSAWAC GVLVGLGHTP FIFSLPFCGP NTIPQFFCEI
     QPVLQLVCGD TSLNELQIIL ATALLILCPF GLILGSYGRI LVTIFRIPSV AGRRKAFSTC
     SSHLIMVSLF YGTALFIYIR PKASYDPATD PLVSLFYAVV TPILNPIIYS LRNTEVKAAL
     KRTIQKTVPM EI
//