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Q96KK4

- O10C1_HUMAN

UniProt

Q96KK4 - O10C1_HUMAN

Protein

Olfactory receptor 10C1

Gene

OR10C1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 121 (01 Oct 2014)
      Sequence version 3 (18 May 2010)
      Previous versions | rss
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    Functioni

    Odorant receptor.Curated

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: UniProtKB-KW
    2. olfactory receptor activity Source: InterPro

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Olfaction, Sensory transduction

    Enzyme and pathway databases

    ReactomeiREACT_15488. Olfactory Signaling Pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Olfactory receptor 10C1
    Alternative name(s):
    Hs6M1-17
    Olfactory receptor 10C2
    Gene namesi
    Name:OR10C1
    Synonyms:OR10C2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 6

    Organism-specific databases

    HGNCiHGNC:8165. OR10C1.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 312312Olfactory receptor 10C1PRO_0000150693Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi4 – 41N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi96 ↔ 188PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ96KK4.
    PRIDEiQ96KK4.

    PTM databases

    PhosphoSiteiQ96KK4.

    Expressioni

    Gene expression databases

    BgeeiQ96KK4.
    CleanExiHS_OR10C1.
    GenevestigatoriQ96KK4.

    Organism-specific databases

    HPAiHPA049336.

    Structurei

    3D structure databases

    ProteinModelPortaliQ96KK4.
    SMRiQ96KK4. Positions 28-308.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2424ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini46 – 538CytoplasmicSequence Analysis
    Topological domaini75 – 9824ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini120 – 13819CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini160 – 19637ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini217 – 23620CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini258 – 27013ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini292 – 31221CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei25 – 4521Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei54 – 7421Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei99 – 11921Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei139 – 15921Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei197 – 21620Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei237 – 25721Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei271 – 29121Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG145065.
    HOVERGENiHBG017625.
    InParanoidiQ96KK4.
    KOiK04257.
    OMAiTIQKMRP.
    OrthoDBiEOG7W9RV4.
    PhylomeDBiQ96KK4.
    TreeFamiTF337350.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q96KK4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSANTSMVTE FLLLGFSHLA DLQGLLFSVF LTIYLLTVAG NFLIVVLVST    50
    DAALQSPMYF FLRTLSALEI GYTSVTVPLL LHHLLTGRRH ISRSGCALQM 100
    FFFLFFGATE CCLLAAMAYD RYAAICEPLR YPLLLSHRVC LQLAGSAWAC 150
    GVLVGLGHTP FIFSLPFCGP NTIPQFFCEI QPVLQLVCGD TSLNELQIIL 200
    ATALLILCPF GLILGSYGRI LVTIFRIPSV AGRRKAFSTC SSHLIMVSLF 250
    YGTALFIYIR PKASYDPATD PLVSLFYAVV TPILNPIIYS LRNTEVKAAL 300
    KRTIQKTVPM EI 312
    Length:312
    Mass (Da):34,384
    Last modified:May 18, 2010 - v3
    Checksum:iB6FD7A4A2018F69C
    GO

    Sequence cautioni

    The sequence CAB44507.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

    Polymorphismi

    A stop codon at position Gln-55 in the gene coding for this protein is responsible for functional diversity thus producing a pseudogene. The stop codon is more frequent in African-Americans than in non-Africans.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti57 – 571P → S.
    Corresponds to variant rs17184016 [ dbSNP | Ensembl ].
    VAR_037822
    Natural varianti60 – 601F → L.
    Corresponds to variant rs2074469 [ dbSNP | Ensembl ].
    VAR_037823
    Natural varianti89 – 891R → S.
    Corresponds to variant rs11755182 [ dbSNP | Ensembl ].
    VAR_037824
    Natural varianti100 – 1001M → V.
    Corresponds to variant rs17177632 [ dbSNP | Ensembl ].
    VAR_037825
    Natural varianti121 – 1211R → C.
    Corresponds to variant rs17177639 [ dbSNP | Ensembl ].
    VAR_037826
    Natural varianti138 – 1381R → W.
    Corresponds to variant rs17177646 [ dbSNP | Ensembl ].
    VAR_037827
    Natural varianti160 – 1601P → S.
    Corresponds to variant rs2074468 [ dbSNP | Ensembl ].
    VAR_037828
    Natural varianti161 – 1611F → L.
    Corresponds to variant rs2074467 [ dbSNP | Ensembl ].
    VAR_037829
    Natural varianti174 – 1741P → Q.
    Corresponds to variant rs2074466 [ dbSNP | Ensembl ].
    VAR_037830
    Natural varianti246 – 2461M → V.2 Publications
    Corresponds to variant rs2074464 [ dbSNP | Ensembl ].
    VAR_037831
    Natural varianti255 – 2551L → I.
    Corresponds to variant rs17177674 [ dbSNP | Ensembl ].
    VAR_037832
    Natural varianti310 – 3101M → R.
    Corresponds to variant rs11968123 [ dbSNP | Ensembl ].
    VAR_037833

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL035542 Genomic DNA. Translation: CAB44507.1. Different initiation.
    AL645927 Genomic DNA. Translation: CAI18054.1.
    CR759768 Genomic DNA. Translation: CAQ09887.1.
    CR388393 Genomic DNA. Translation: CAQ10823.1.
    BC136996 mRNA. Translation: AAI36997.1.
    BC136997 mRNA. Translation: AAI36998.1.
    AF399627 Genomic DNA. Translation: AAK95112.1.
    CCDSiCCDS34364.1.
    RefSeqiNP_039229.3. NM_013941.3.
    UniGeneiHs.631997.

    Genome annotation databases

    EnsembliENST00000377138; ENSP00000366343; ENSG00000229412.
    ENST00000391549; ENSP00000375393; ENSG00000204689.
    ENST00000437403; ENSP00000408961; ENSG00000224234.
    ENST00000444197; ENSP00000419119; ENSG00000206474.
    ENST00000455234; ENSP00000402486; ENSG00000230505.
    ENST00000457403; ENSP00000412512; ENSG00000232397.
    GeneIDi442194.
    KEGGihsa:442194.
    UCSCiuc011dlp.2. human.

    Polymorphism databases

    DMDMi296439284.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Human Olfactory Receptor Data Exploratorium (HORDE)

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL035542 Genomic DNA. Translation: CAB44507.1 . Different initiation.
    AL645927 Genomic DNA. Translation: CAI18054.1 .
    CR759768 Genomic DNA. Translation: CAQ09887.1 .
    CR388393 Genomic DNA. Translation: CAQ10823.1 .
    BC136996 mRNA. Translation: AAI36997.1 .
    BC136997 mRNA. Translation: AAI36998.1 .
    AF399627 Genomic DNA. Translation: AAK95112.1 .
    CCDSi CCDS34364.1.
    RefSeqi NP_039229.3. NM_013941.3.
    UniGenei Hs.631997.

    3D structure databases

    ProteinModelPortali Q96KK4.
    SMRi Q96KK4. Positions 28-308.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei Q96KK4.

    Polymorphism databases

    DMDMi 296439284.

    Proteomic databases

    PaxDbi Q96KK4.
    PRIDEi Q96KK4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000377138 ; ENSP00000366343 ; ENSG00000229412 .
    ENST00000391549 ; ENSP00000375393 ; ENSG00000204689 .
    ENST00000437403 ; ENSP00000408961 ; ENSG00000224234 .
    ENST00000444197 ; ENSP00000419119 ; ENSG00000206474 .
    ENST00000455234 ; ENSP00000402486 ; ENSG00000230505 .
    ENST00000457403 ; ENSP00000412512 ; ENSG00000232397 .
    GeneIDi 442194.
    KEGGi hsa:442194.
    UCSCi uc011dlp.2. human.

    Organism-specific databases

    CTDi 442194.
    GeneCardsi GC06P029407.
    GC06Pi29407.
    GC06Pj29382.
    GC06Pk29384.
    GC06Pl29385.
    GC06Pm29384.
    HGNCi HGNC:8165. OR10C1.
    HPAi HPA049336.
    neXtProti NX_Q96KK4.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG145065.
    HOVERGENi HBG017625.
    InParanoidi Q96KK4.
    KOi K04257.
    OMAi TIQKMRP.
    OrthoDBi EOG7W9RV4.
    PhylomeDBi Q96KK4.
    TreeFami TF337350.

    Enzyme and pathway databases

    Reactomei REACT_15488. Olfactory Signaling Pathway.

    Miscellaneous databases

    GeneWikii OR10C1.
    GenomeRNAii 442194.
    NextBioi 110824.
    PROi Q96KK4.

    Gene expression databases

    Bgeei Q96KK4.
    CleanExi HS_OR10C1.
    Genevestigatori Q96KK4.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
      Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT VAL-246.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis.
    3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 67-282, VARIANT VAL-246.
    4. Cited for: POLYMORPHISM.

    Entry informationi

    Entry nameiO10C1_HUMAN
    AccessioniPrimary (citable) accession number: Q96KK4
    Secondary accession number(s): Q5SUN7, Q96R18
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 23, 2002
    Last sequence update: May 18, 2010
    Last modified: October 1, 2014
    This is version 121 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3