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Protein

Olfactory receptor 10C1

Gene

OR10C1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. olfactory receptor activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 10C1
Alternative name(s):
Hs6M1-17
Olfactory receptor 10C2
Gene namesi
Name:OR10C1
Synonyms:OR10C2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 6, UP000005640: Unplaced

Organism-specific databases

HGNCiHGNC:8165. OR10C1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2424ExtracellularSequence AnalysisAdd
BLAST
Transmembranei25 – 4521Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini46 – 538CytoplasmicSequence Analysis
Transmembranei54 – 7421Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini75 – 9824ExtracellularSequence AnalysisAdd
BLAST
Transmembranei99 – 11921Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini120 – 13819CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei139 – 15921Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini160 – 19637ExtracellularSequence AnalysisAdd
BLAST
Transmembranei197 – 21620Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini217 – 23620CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei237 – 25721Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini258 – 27013ExtracellularSequence AnalysisAdd
BLAST
Transmembranei271 – 29121Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini292 – 31221CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 312312Olfactory receptor 10C1PRO_0000150693Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi4 – 41N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi96 ↔ 188PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ96KK4.
PRIDEiQ96KK4.

PTM databases

PhosphoSiteiQ96KK4.

Expressioni

Gene expression databases

BgeeiQ96KK4.
CleanExiHS_OR10C1.
GenevestigatoriQ96KK4.

Organism-specific databases

HPAiHPA049336.

Structurei

3D structure databases

ProteinModelPortaliQ96KK4.
SMRiQ96KK4. Positions 28-308.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG145065.
GeneTreeiENSGT00760000119002.
HOVERGENiHBG017625.
InParanoidiQ96KK4.
KOiK04257.
OrthoDBiEOG7W9RV4.
PhylomeDBiQ96KK4.
TreeFamiTF337350.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96KK4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSANTSMVTE FLLLGFSHLA DLQGLLFSVF LTIYLLTVAG NFLIVVLVST
60 70 80 90 100
DAALQSPMYF FLRTLSALEI GYTSVTVPLL LHHLLTGRRH ISRSGCALQM
110 120 130 140 150
FFFLFFGATE CCLLAAMAYD RYAAICEPLR YPLLLSHRVC LQLAGSAWAC
160 170 180 190 200
GVLVGLGHTP FIFSLPFCGP NTIPQFFCEI QPVLQLVCGD TSLNELQIIL
210 220 230 240 250
ATALLILCPF GLILGSYGRI LVTIFRIPSV AGRRKAFSTC SSHLIMVSLF
260 270 280 290 300
YGTALFIYIR PKASYDPATD PLVSLFYAVV TPILNPIIYS LRNTEVKAAL
310
KRTIQKTVPM EI
Length:312
Mass (Da):34,384
Last modified:May 18, 2010 - v3
Checksum:iB6FD7A4A2018F69C
GO

Sequence cautioni

The sequence CAB44507.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Polymorphismi

A stop codon at position Gln-55 in the gene coding for this protein is responsible for functional diversity thus producing a pseudogene. The stop codon is more frequent in African-Americans than in non-Africans.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti57 – 571P → S.
Corresponds to variant rs17184016 [ dbSNP | Ensembl ].
VAR_037822
Natural varianti60 – 601F → L.
Corresponds to variant rs2074469 [ dbSNP | Ensembl ].
VAR_037823
Natural varianti89 – 891R → S.
Corresponds to variant rs11755182 [ dbSNP | Ensembl ].
VAR_037824
Natural varianti100 – 1001M → V.
Corresponds to variant rs17177632 [ dbSNP | Ensembl ].
VAR_037825
Natural varianti121 – 1211R → C.
Corresponds to variant rs17177639 [ dbSNP | Ensembl ].
VAR_037826
Natural varianti138 – 1381R → W.
Corresponds to variant rs17177646 [ dbSNP | Ensembl ].
VAR_037827
Natural varianti160 – 1601P → S.
Corresponds to variant rs2074468 [ dbSNP | Ensembl ].
VAR_037828
Natural varianti161 – 1611F → L.
Corresponds to variant rs2074467 [ dbSNP | Ensembl ].
VAR_037829
Natural varianti174 – 1741P → Q.
Corresponds to variant rs2074466 [ dbSNP | Ensembl ].
VAR_037830
Natural varianti246 – 2461M → V.2 Publications
Corresponds to variant rs2074464 [ dbSNP | Ensembl ].
VAR_037831
Natural varianti255 – 2551L → I.
Corresponds to variant rs17177674 [ dbSNP | Ensembl ].
VAR_037832
Natural varianti310 – 3101M → R.
Corresponds to variant rs11968123 [ dbSNP | Ensembl ].
VAR_037833

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL035542 Genomic DNA. Translation: CAB44507.1. Different initiation.
AL645927 Genomic DNA. Translation: CAI18054.1.
CR759768 Genomic DNA. Translation: CAQ09887.1.
CR388393 Genomic DNA. Translation: CAQ10823.1.
BC136996 mRNA. Translation: AAI36997.1.
BC136997 mRNA. Translation: AAI36998.1.
AF399627 Genomic DNA. Translation: AAK95112.1.
CCDSiCCDS34364.1.
RefSeqiNP_039229.3. NM_013941.3.
UniGeneiHs.631997.

Genome annotation databases

EnsembliENST00000377138; ENSP00000366343; ENSG00000229412.
ENST00000391549; ENSP00000375393; ENSG00000204689.
ENST00000437403; ENSP00000408961; ENSG00000224234.
ENST00000444197; ENSP00000419119; ENSG00000206474.
ENST00000455234; ENSP00000402486; ENSG00000230505.
ENST00000457403; ENSP00000412512; ENSG00000232397.
ENST00000623086; ENSP00000485032; ENSG00000279941.
GeneIDi442194.
KEGGihsa:442194.
UCSCiuc011dlp.2. human.

Polymorphism databases

DMDMi296439284.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL035542 Genomic DNA. Translation: CAB44507.1. Different initiation.
AL645927 Genomic DNA. Translation: CAI18054.1.
CR759768 Genomic DNA. Translation: CAQ09887.1.
CR388393 Genomic DNA. Translation: CAQ10823.1.
BC136996 mRNA. Translation: AAI36997.1.
BC136997 mRNA. Translation: AAI36998.1.
AF399627 Genomic DNA. Translation: AAK95112.1.
CCDSiCCDS34364.1.
RefSeqiNP_039229.3. NM_013941.3.
UniGeneiHs.631997.

3D structure databases

ProteinModelPortaliQ96KK4.
SMRiQ96KK4. Positions 28-308.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiQ96KK4.

Polymorphism databases

DMDMi296439284.

Proteomic databases

PaxDbiQ96KK4.
PRIDEiQ96KK4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000377138; ENSP00000366343; ENSG00000229412.
ENST00000391549; ENSP00000375393; ENSG00000204689.
ENST00000437403; ENSP00000408961; ENSG00000224234.
ENST00000444197; ENSP00000419119; ENSG00000206474.
ENST00000455234; ENSP00000402486; ENSG00000230505.
ENST00000457403; ENSP00000412512; ENSG00000232397.
ENST00000623086; ENSP00000485032; ENSG00000279941.
GeneIDi442194.
KEGGihsa:442194.
UCSCiuc011dlp.2. human.

Organism-specific databases

CTDi442194.
GeneCardsiGC06P029407.
GC06Pi29407.
GC06Pj29382.
GC06Pk29384.
GC06Pl29385.
GC06Pm29384.
HGNCiHGNC:8165. OR10C1.
HPAiHPA049336.
neXtProtiNX_Q96KK4.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG145065.
GeneTreeiENSGT00760000119002.
HOVERGENiHBG017625.
InParanoidiQ96KK4.
KOiK04257.
OrthoDBiEOG7W9RV4.
PhylomeDBiQ96KK4.
TreeFamiTF337350.

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR10C1.
GenomeRNAii442194.
NextBioi110824.
PROiQ96KK4.

Gene expression databases

BgeeiQ96KK4.
CleanExiHS_OR10C1.
GenevestigatoriQ96KK4.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT VAL-246.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 67-282, VARIANT VAL-246.
  4. Cited for: POLYMORPHISM.

Entry informationi

Entry nameiO10C1_HUMAN
AccessioniPrimary (citable) accession number: Q96KK4
Secondary accession number(s): Q5SUN7, Q96R18
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: May 18, 2010
Last modified: January 7, 2015
This is version 124 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.