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Q96KK4

- O10C1_HUMAN

UniProt

Q96KK4 - O10C1_HUMAN

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Protein

Olfactory receptor 10C1

Gene
OR10C1, OR10C2
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Odorant receptor Reviewed prediction.

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. olfactory receptor activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 10C1
Alternative name(s):
Hs6M1-17
Olfactory receptor 10C2
Gene namesi
Name:OR10C1
Synonyms:OR10C2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 6

Organism-specific databases

HGNCiHGNC:8165. OR10C1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2424Extracellular Reviewed predictionAdd
BLAST
Transmembranei25 – 4521Helical; Name=1; Reviewed predictionAdd
BLAST
Topological domaini46 – 538Cytoplasmic Reviewed prediction
Transmembranei54 – 7421Helical; Name=2; Reviewed predictionAdd
BLAST
Topological domaini75 – 9824Extracellular Reviewed predictionAdd
BLAST
Transmembranei99 – 11921Helical; Name=3; Reviewed predictionAdd
BLAST
Topological domaini120 – 13819Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei139 – 15921Helical; Name=4; Reviewed predictionAdd
BLAST
Topological domaini160 – 19637Extracellular Reviewed predictionAdd
BLAST
Transmembranei197 – 21620Helical; Name=5; Reviewed predictionAdd
BLAST
Topological domaini217 – 23620Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei237 – 25721Helical; Name=6; Reviewed predictionAdd
BLAST
Topological domaini258 – 27013Extracellular Reviewed predictionAdd
BLAST
Transmembranei271 – 29121Helical; Name=7; Reviewed predictionAdd
BLAST
Topological domaini292 – 31221Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 312312Olfactory receptor 10C1PRO_0000150693Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi4 – 41N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi96 ↔ 188 By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ96KK4.
PRIDEiQ96KK4.

PTM databases

PhosphoSiteiQ96KK4.

Expressioni

Gene expression databases

BgeeiQ96KK4.
CleanExiHS_OR10C1.
GenevestigatoriQ96KK4.

Organism-specific databases

HPAiHPA049336.

Structurei

3D structure databases

ProteinModelPortaliQ96KK4.
SMRiQ96KK4. Positions 28-308.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG145065.
HOVERGENiHBG017625.
InParanoidiQ96KK4.
KOiK04257.
OMAiTIQKMRP.
OrthoDBiEOG7W9RV4.
PhylomeDBiQ96KK4.
TreeFamiTF337350.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96KK4-1 [UniParc]FASTAAdd to Basket

« Hide

MSANTSMVTE FLLLGFSHLA DLQGLLFSVF LTIYLLTVAG NFLIVVLVST    50
DAALQSPMYF FLRTLSALEI GYTSVTVPLL LHHLLTGRRH ISRSGCALQM 100
FFFLFFGATE CCLLAAMAYD RYAAICEPLR YPLLLSHRVC LQLAGSAWAC 150
GVLVGLGHTP FIFSLPFCGP NTIPQFFCEI QPVLQLVCGD TSLNELQIIL 200
ATALLILCPF GLILGSYGRI LVTIFRIPSV AGRRKAFSTC SSHLIMVSLF 250
YGTALFIYIR PKASYDPATD PLVSLFYAVV TPILNPIIYS LRNTEVKAAL 300
KRTIQKTVPM EI 312
Length:312
Mass (Da):34,384
Last modified:May 18, 2010 - v3
Checksum:iB6FD7A4A2018F69C
GO

Sequence cautioni

The sequence CAB44507.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Polymorphismi

A stop codon at position Gln-55 in the gene coding for this protein is responsible for functional diversity thus producing a pseudogene. The stop codon is more frequent in African-Americans than in non-Africans.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti57 – 571P → S.
Corresponds to variant rs17184016 [ dbSNP | Ensembl ].
VAR_037822
Natural varianti60 – 601F → L.
Corresponds to variant rs2074469 [ dbSNP | Ensembl ].
VAR_037823
Natural varianti89 – 891R → S.
Corresponds to variant rs11755182 [ dbSNP | Ensembl ].
VAR_037824
Natural varianti100 – 1001M → V.
Corresponds to variant rs17177632 [ dbSNP | Ensembl ].
VAR_037825
Natural varianti121 – 1211R → C.
Corresponds to variant rs17177639 [ dbSNP | Ensembl ].
VAR_037826
Natural varianti138 – 1381R → W.
Corresponds to variant rs17177646 [ dbSNP | Ensembl ].
VAR_037827
Natural varianti160 – 1601P → S.
Corresponds to variant rs2074468 [ dbSNP | Ensembl ].
VAR_037828
Natural varianti161 – 1611F → L.
Corresponds to variant rs2074467 [ dbSNP | Ensembl ].
VAR_037829
Natural varianti174 – 1741P → Q.
Corresponds to variant rs2074466 [ dbSNP | Ensembl ].
VAR_037830
Natural varianti246 – 2461M → V.2 Publications
Corresponds to variant rs2074464 [ dbSNP | Ensembl ].
VAR_037831
Natural varianti255 – 2551L → I.
Corresponds to variant rs17177674 [ dbSNP | Ensembl ].
VAR_037832
Natural varianti310 – 3101M → R.
Corresponds to variant rs11968123 [ dbSNP | Ensembl ].
VAR_037833

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL035542 Genomic DNA. Translation: CAB44507.1. Different initiation.
AL645927 Genomic DNA. Translation: CAI18054.1.
CR759768 Genomic DNA. Translation: CAQ09887.1.
CR388393 Genomic DNA. Translation: CAQ10823.1.
BC136996 mRNA. Translation: AAI36997.1.
BC136997 mRNA. Translation: AAI36998.1.
AF399627 Genomic DNA. Translation: AAK95112.1.
CCDSiCCDS34364.1.
RefSeqiNP_039229.3. NM_013941.3.
UniGeneiHs.631997.

Genome annotation databases

EnsembliENST00000377138; ENSP00000366343; ENSG00000229412.
ENST00000391549; ENSP00000375393; ENSG00000204689.
ENST00000437403; ENSP00000408961; ENSG00000224234.
ENST00000444197; ENSP00000419119; ENSG00000206474.
ENST00000455234; ENSP00000402486; ENSG00000230505.
ENST00000457403; ENSP00000412512; ENSG00000232397.
GeneIDi442194.
KEGGihsa:442194.
UCSCiuc011dlp.2. human.

Polymorphism databases

DMDMi296439284.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL035542 Genomic DNA. Translation: CAB44507.1 . Different initiation.
AL645927 Genomic DNA. Translation: CAI18054.1 .
CR759768 Genomic DNA. Translation: CAQ09887.1 .
CR388393 Genomic DNA. Translation: CAQ10823.1 .
BC136996 mRNA. Translation: AAI36997.1 .
BC136997 mRNA. Translation: AAI36998.1 .
AF399627 Genomic DNA. Translation: AAK95112.1 .
CCDSi CCDS34364.1.
RefSeqi NP_039229.3. NM_013941.3.
UniGenei Hs.631997.

3D structure databases

ProteinModelPortali Q96KK4.
SMRi Q96KK4. Positions 28-308.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei Q96KK4.

Polymorphism databases

DMDMi 296439284.

Proteomic databases

PaxDbi Q96KK4.
PRIDEi Q96KK4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000377138 ; ENSP00000366343 ; ENSG00000229412 .
ENST00000391549 ; ENSP00000375393 ; ENSG00000204689 .
ENST00000437403 ; ENSP00000408961 ; ENSG00000224234 .
ENST00000444197 ; ENSP00000419119 ; ENSG00000206474 .
ENST00000455234 ; ENSP00000402486 ; ENSG00000230505 .
ENST00000457403 ; ENSP00000412512 ; ENSG00000232397 .
GeneIDi 442194.
KEGGi hsa:442194.
UCSCi uc011dlp.2. human.

Organism-specific databases

CTDi 442194.
GeneCardsi GC06P029407.
GC06Pi29407.
GC06Pj29382.
GC06Pk29384.
GC06Pl29385.
GC06Pm29384.
HGNCi HGNC:8165. OR10C1.
HPAi HPA049336.
neXtProti NX_Q96KK4.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG145065.
HOVERGENi HBG017625.
InParanoidi Q96KK4.
KOi K04257.
OMAi TIQKMRP.
OrthoDBi EOG7W9RV4.
PhylomeDBi Q96KK4.
TreeFami TF337350.

Enzyme and pathway databases

Reactomei REACT_15488. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikii OR10C1.
GenomeRNAii 442194.
NextBioi 110824.
PROi Q96KK4.

Gene expression databases

Bgeei Q96KK4.
CleanExi HS_OR10C1.
Genevestigatori Q96KK4.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT VAL-246.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 67-282, VARIANT VAL-246.
  4. Cited for: POLYMORPHISM.

Entry informationi

Entry nameiO10C1_HUMAN
AccessioniPrimary (citable) accession number: Q96KK4
Secondary accession number(s): Q5SUN7, Q96R18
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: May 18, 2010
Last modified: September 3, 2014
This is version 120 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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