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Q96KK4 (O10C1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 119. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Olfactory receptor 10C1
Alternative name(s):
Hs6M1-17
Olfactory receptor 10C2
Gene names
Name:OR10C1
Synonyms:OR10C2
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length312 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Odorant receptor Potential.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Polymorphism

A stop codon at position Gln-55 in the gene coding for this protein is responsible for functional diversity thus producing a pseudogene. The stop codon is more frequent in African-Americans than in non-Africans.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Sequence caution

The sequence CAB44507.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 312312Olfactory receptor 10C1
PRO_0000150693

Regions

Topological domain1 – 2424Extracellular Potential
Transmembrane25 – 4521Helical; Name=1; Potential
Topological domain46 – 538Cytoplasmic Potential
Transmembrane54 – 7421Helical; Name=2; Potential
Topological domain75 – 9824Extracellular Potential
Transmembrane99 – 11921Helical; Name=3; Potential
Topological domain120 – 13819Cytoplasmic Potential
Transmembrane139 – 15921Helical; Name=4; Potential
Topological domain160 – 19637Extracellular Potential
Transmembrane197 – 21620Helical; Name=5; Potential
Topological domain217 – 23620Cytoplasmic Potential
Transmembrane237 – 25721Helical; Name=6; Potential
Topological domain258 – 27013Extracellular Potential
Transmembrane271 – 29121Helical; Name=7; Potential
Topological domain292 – 31221Cytoplasmic Potential

Amino acid modifications

Glycosylation41N-linked (GlcNAc...) Potential
Disulfide bond96 ↔ 188 By similarity

Natural variations

Natural variant571P → S.
Corresponds to variant rs17184016 [ dbSNP | Ensembl ].
VAR_037822
Natural variant601F → L.
Corresponds to variant rs2074469 [ dbSNP | Ensembl ].
VAR_037823
Natural variant891R → S.
Corresponds to variant rs11755182 [ dbSNP | Ensembl ].
VAR_037824
Natural variant1001M → V.
Corresponds to variant rs17177632 [ dbSNP | Ensembl ].
VAR_037825
Natural variant1211R → C.
Corresponds to variant rs17177639 [ dbSNP | Ensembl ].
VAR_037826
Natural variant1381R → W.
Corresponds to variant rs17177646 [ dbSNP | Ensembl ].
VAR_037827
Natural variant1601P → S.
Corresponds to variant rs2074468 [ dbSNP | Ensembl ].
VAR_037828
Natural variant1611F → L.
Corresponds to variant rs2074467 [ dbSNP | Ensembl ].
VAR_037829
Natural variant1741P → Q.
Corresponds to variant rs2074466 [ dbSNP | Ensembl ].
VAR_037830
Natural variant2461M → V. Ref.1 Ref.3
Corresponds to variant rs2074464 [ dbSNP | Ensembl ].
VAR_037831
Natural variant2551L → I.
Corresponds to variant rs17177674 [ dbSNP | Ensembl ].
VAR_037832
Natural variant3101M → R.
Corresponds to variant rs11968123 [ dbSNP | Ensembl ].
VAR_037833

Sequences

Sequence LengthMass (Da)Tools
Q96KK4 [UniParc].

Last modified May 18, 2010. Version 3.
Checksum: B6FD7A4A2018F69C

FASTA31234,384
        10         20         30         40         50         60 
MSANTSMVTE FLLLGFSHLA DLQGLLFSVF LTIYLLTVAG NFLIVVLVST DAALQSPMYF 

        70         80         90        100        110        120 
FLRTLSALEI GYTSVTVPLL LHHLLTGRRH ISRSGCALQM FFFLFFGATE CCLLAAMAYD 

       130        140        150        160        170        180 
RYAAICEPLR YPLLLSHRVC LQLAGSAWAC GVLVGLGHTP FIFSLPFCGP NTIPQFFCEI 

       190        200        210        220        230        240 
QPVLQLVCGD TSLNELQIIL ATALLILCPF GLILGSYGRI LVTIFRIPSV AGRRKAFSTC 

       250        260        270        280        290        300 
SSHLIMVSLF YGTALFIYIR PKASYDPATD PLVSLFYAVV TPILNPIIYS LRNTEVKAAL 

       310 
KRTIQKTVPM EI 

« Hide

References

« Hide 'large scale' references
[1]"The DNA sequence and analysis of human chromosome 6."
Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. expand/collapse author list , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT VAL-246.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Testis.
[3]"DEFOG: a practical scheme for deciphering families of genes."
Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R., Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U., Lehrach H., Lancet D., Shamir R.
Genomics 80:295-302(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 67-282, VARIANT VAL-246.
[4]"Different noses for different people."
Menashe I., Man O., Lancet D., Gilad Y.
Nat. Genet. 34:143-144(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: POLYMORPHISM.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL035542 Genomic DNA. Translation: CAB44507.1. Different initiation.
AL645927 Genomic DNA. Translation: CAI18054.1.
CR759768 Genomic DNA. Translation: CAQ09887.1.
CR388393 Genomic DNA. Translation: CAQ10823.1.
BC136996 mRNA. Translation: AAI36997.1.
BC136997 mRNA. Translation: AAI36998.1.
AF399627 Genomic DNA. Translation: AAK95112.1.
CCDSCCDS34364.1.
RefSeqNP_039229.3. NM_013941.3.
UniGeneHs.631997.

3D structure databases

ProteinModelPortalQ96KK4.
SMRQ96KK4. Positions 28-308.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteQ96KK4.

Polymorphism databases

DMDM296439284.

Proteomic databases

PaxDbQ96KK4.
PRIDEQ96KK4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000377138; ENSP00000366343; ENSG00000229412.
ENST00000391549; ENSP00000375393; ENSG00000204689.
ENST00000437403; ENSP00000408961; ENSG00000224234.
ENST00000444197; ENSP00000419119; ENSG00000206474.
ENST00000455234; ENSP00000402486; ENSG00000230505.
ENST00000457403; ENSP00000412512; ENSG00000232397.
GeneID442194.
KEGGhsa:442194.
UCSCuc011dlp.2. human.

Organism-specific databases

CTD442194.
GeneCardsGC06P029407.
GC06Pi29407.
GC06Pj29382.
GC06Pk29384.
GC06Pl29385.
GC06Pm29384.
HGNCHGNC:8165. OR10C1.
HPAHPA049336.
neXtProtNX_Q96KK4.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG145065.
HOVERGENHBG017625.
InParanoidQ96KK4.
KOK04257.
OMATIQKMRP.
OrthoDBEOG7W9RV4.
PhylomeDBQ96KK4.
TreeFamTF337350.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

BgeeQ96KK4.
CleanExHS_OR10C1.
GenevestigatorQ96KK4.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiOR10C1.
GenomeRNAi442194.
NextBio110824.
PROQ96KK4.

Entry information

Entry nameO10C1_HUMAN
AccessionPrimary (citable) accession number: Q96KK4
Secondary accession number(s): Q5SUN7, Q96R18
Entry history
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: May 18, 2010
Last modified: July 9, 2014
This is version 119 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 6

Human chromosome 6: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries