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Protein

Olfactory receptor 10C1

Gene

OR10C1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

BioCyciZFISH:ENSG00000181207-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 10C1
Alternative name(s):
Hs6M1-17
Olfactory receptor 10C2
Gene namesi
Name:OR10C1
Synonyms:OR10C2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:8165. OR10C1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 24ExtracellularSequence analysisAdd BLAST24
Transmembranei25 – 45Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini46 – 53CytoplasmicSequence analysis8
Transmembranei54 – 74Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini75 – 98ExtracellularSequence analysisAdd BLAST24
Transmembranei99 – 119Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini120 – 138CytoplasmicSequence analysisAdd BLAST19
Transmembranei139 – 159Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini160 – 196ExtracellularSequence analysisAdd BLAST37
Transmembranei197 – 216Helical; Name=5Sequence analysisAdd BLAST20
Topological domaini217 – 236CytoplasmicSequence analysisAdd BLAST20
Transmembranei237 – 257Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini258 – 270ExtracellularSequence analysisAdd BLAST13
Transmembranei271 – 291Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini292 – 312CytoplasmicSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000204689.
ENSG00000206474.
ENSG00000229412.

Polymorphism and mutation databases

BioMutaiOR10C1.
DMDMi296439284.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001506931 – 312Olfactory receptor 10C1Add BLAST312

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi4N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi96 ↔ 188PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ96KK4.
PRIDEiQ96KK4.

PTM databases

iPTMnetiQ96KK4.
PhosphoSitePlusiQ96KK4.

Expressioni

Gene expression databases

BgeeiENSG00000206474.
CleanExiHS_OR10C1.
ExpressionAtlasiQ96KK4. differential.
GenevisibleiQ96KK4. HS.

Organism-specific databases

HPAiHPA049336.

Structurei

3D structure databases

ProteinModelPortaliQ96KK4.
SMRiQ96KK4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410ITUP. Eukaryota.
ENOG4111574. LUCA.
GeneTreeiENSGT00760000119002.
HOVERGENiHBG017625.
InParanoidiQ96KK4.
KOiK04257.
PhylomeDBiQ96KK4.
TreeFamiTF337350.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96KK4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSANTSMVTE FLLLGFSHLA DLQGLLFSVF LTIYLLTVAG NFLIVVLVST
60 70 80 90 100
DAALQSPMYF FLRTLSALEI GYTSVTVPLL LHHLLTGRRH ISRSGCALQM
110 120 130 140 150
FFFLFFGATE CCLLAAMAYD RYAAICEPLR YPLLLSHRVC LQLAGSAWAC
160 170 180 190 200
GVLVGLGHTP FIFSLPFCGP NTIPQFFCEI QPVLQLVCGD TSLNELQIIL
210 220 230 240 250
ATALLILCPF GLILGSYGRI LVTIFRIPSV AGRRKAFSTC SSHLIMVSLF
260 270 280 290 300
YGTALFIYIR PKASYDPATD PLVSLFYAVV TPILNPIIYS LRNTEVKAAL
310
KRTIQKTVPM EI
Length:312
Mass (Da):34,384
Last modified:May 18, 2010 - v3
Checksum:iB6FD7A4A2018F69C
GO

Sequence cautioni

The sequence CAB44507 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Polymorphismi

A stop codon at position Gln-55 in the gene coding for this protein is responsible for functional diversity thus producing a pseudogene. The stop codon is more frequent in African-Americans than in non-Africans.

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03782257P → S.Corresponds to variant rs17184016dbSNPEnsembl.1
Natural variantiVAR_03782360F → L.Corresponds to variant rs2074469dbSNPEnsembl.1
Natural variantiVAR_03782489R → S.Corresponds to variant rs11755182dbSNPEnsembl.1
Natural variantiVAR_037825100M → V.Corresponds to variant rs17177632dbSNPEnsembl.1
Natural variantiVAR_037826121R → C.Corresponds to variant rs17177639dbSNPEnsembl.1
Natural variantiVAR_037827138R → W.Corresponds to variant rs17177646dbSNPEnsembl.1
Natural variantiVAR_037828160P → S.Corresponds to variant rs2074468dbSNPEnsembl.1
Natural variantiVAR_037829161F → L.Corresponds to variant rs2074467dbSNPEnsembl.1
Natural variantiVAR_037830174P → Q.Corresponds to variant rs2074466dbSNPEnsembl.1
Natural variantiVAR_037831246M → V.2 PublicationsCorresponds to variant rs2074464dbSNPEnsembl.1
Natural variantiVAR_037832255L → I.Corresponds to variant rs17177674dbSNPEnsembl.1
Natural variantiVAR_037833310M → R.Corresponds to variant rs11968123dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL035542 Genomic DNA. Translation: CAB44507.1. Different initiation.
AL645927 Genomic DNA. Translation: CAI18054.1.
CR759768 Genomic DNA. Translation: CAQ09887.1.
CR388393 Genomic DNA. Translation: CAQ10823.1.
BC136996 mRNA. Translation: AAI36997.1.
BC136997 mRNA. Translation: AAI36998.1.
AF399627 Genomic DNA. Translation: AAK95112.1.
CCDSiCCDS34364.1.
RefSeqiNP_039229.3. NM_013941.3.
UniGeneiHs.631997.

Genome annotation databases

EnsembliENST00000377138; ENSP00000366343; ENSG00000229412.
ENST00000391549; ENSP00000375393; ENSG00000204689.
ENST00000437403; ENSP00000408961; ENSG00000224234.
ENST00000444197; ENSP00000419119; ENSG00000206474.
ENST00000455234; ENSP00000402486; ENSG00000230505.
ENST00000457403; ENSP00000412512; ENSG00000232397.
GeneIDi442194.
KEGGihsa:442194.
UCSCiuc011dlp.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL035542 Genomic DNA. Translation: CAB44507.1. Different initiation.
AL645927 Genomic DNA. Translation: CAI18054.1.
CR759768 Genomic DNA. Translation: CAQ09887.1.
CR388393 Genomic DNA. Translation: CAQ10823.1.
BC136996 mRNA. Translation: AAI36997.1.
BC136997 mRNA. Translation: AAI36998.1.
AF399627 Genomic DNA. Translation: AAK95112.1.
CCDSiCCDS34364.1.
RefSeqiNP_039229.3. NM_013941.3.
UniGeneiHs.631997.

3D structure databases

ProteinModelPortaliQ96KK4.
SMRiQ96KK4.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ96KK4.
PhosphoSitePlusiQ96KK4.

Polymorphism and mutation databases

BioMutaiOR10C1.
DMDMi296439284.

Proteomic databases

PaxDbiQ96KK4.
PRIDEiQ96KK4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000377138; ENSP00000366343; ENSG00000229412.
ENST00000391549; ENSP00000375393; ENSG00000204689.
ENST00000437403; ENSP00000408961; ENSG00000224234.
ENST00000444197; ENSP00000419119; ENSG00000206474.
ENST00000455234; ENSP00000402486; ENSG00000230505.
ENST00000457403; ENSP00000412512; ENSG00000232397.
GeneIDi442194.
KEGGihsa:442194.
UCSCiuc011dlp.3. human.

Organism-specific databases

CTDi442194.
GeneCardsiOR10C1.
HGNCiHGNC:8165. OR10C1.
HPAiHPA049336.
neXtProtiNX_Q96KK4.
OpenTargetsiENSG00000204689.
ENSG00000206474.
ENSG00000229412.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410ITUP. Eukaryota.
ENOG4111574. LUCA.
GeneTreeiENSGT00760000119002.
HOVERGENiHBG017625.
InParanoidiQ96KK4.
KOiK04257.
PhylomeDBiQ96KK4.
TreeFamiTF337350.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000181207-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR10C1.
GenomeRNAii442194.
PROiQ96KK4.

Gene expression databases

BgeeiENSG00000206474.
CleanExiHS_OR10C1.
ExpressionAtlasiQ96KK4. differential.
GenevisibleiQ96KK4. HS.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiO10C1_HUMAN
AccessioniPrimary (citable) accession number: Q96KK4
Secondary accession number(s): Q5SUN7, Q96R18
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: May 18, 2010
Last modified: November 30, 2016
This is version 140 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.