Q96KK3 (KCNS1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Potassium voltage-gated channel subfamily S member 1

Alternative name(s):
Delayed-rectifier K(+) channel alpha subunit 1
Voltage-gated potassium channel subunit Kv9.1

Gene names

Name:

KCNS1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	526 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Potassium channel subunit. Modulates channel activity and reduces the ion flow By similarity.
Subunit structure	Heteromultimer with KCNB1 and with KCNB2. Does not form homomultimers. Might also bind to other channel proteins By similarity.
Subcellular location	Cell membrane; Multi-pass membrane protein. Note: May not reach the plasma membrane but remain in an intracellular compartment in the absence of KCNB1.
Tissue specificity	Detected in all tissues tested with the exception of skeletal muscle. Highly expressed in adult and fetal brain, fetal kidney and lung, and adult prostate and testis.
Domain	The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.
Sequence similarities	Belongs to the potassium channel family. S (TC 1.A.1.2) subfamily. Kv9.1/KCNS1 sub-subfamily. [View classification]

Ontologies

Keywords
Biological process	Ion transport Potassium transport Transport
Cellular component	Cell membrane Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane Transmembrane helix
Ligand	Potassium
Molecular function	Ion channel Potassium channel Voltage-gated channel
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	protein homooligomerization Inferred from electronic annotation. Source: InterPro synaptic transmission Traceable author statement. Source: Reactome
Cellular_component	voltage-gated potassium channel complex Inferred from direct assay Ref.1. Source: UniProtKB
Molecular_function	delayed rectifier potassium channel activity Inferred from direct assay Ref.1. Source: UniProtKB potassium channel regulator activity Inferred from direct assay Ref.1. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 526	526	Potassium voltage-gated channel subfamily S member 1		PRO_0000054081
Regions
	Topological domain	1 – 221	221	Cytoplasmic Potential
	Transmembrane	222 – 242	21	Helical; Name=Segment S1; Potential
	Transmembrane	275 – 295	21	Helical; Name=Segment S2; Potential
	Topological domain	296 – 306	11	Cytoplasmic Potential
	Transmembrane	307 – 327	21	Helical; Name=Segment S3; Potential
	Transmembrane	340 – 360	21	Helical; Voltage-sensor; Name=Segment S4; Potential
	Topological domain	361 – 375	15	Cytoplasmic Potential
	Transmembrane	376 – 396	21	Helical; Name=Segment S5; Potential
	Intramembrane	409 – 429	21	Pore-forming; Name=Segment H5; Potential
	Transmembrane	437 – 457	21	Helical; Name=Segment S6; Potential
	Topological domain	458 – 526	69	Cytoplasmic Potential
	Motif	421 – 426	6	Selectivity filter By similarity
	Compositional bias	250 – 259	10	Poly-Ala
Natural variations
	Natural variant	489	1	I → V. Ref.3 Corresponds to variant rs734784 [ dbSNP | Ensembl ].		VAR_020052
	Natural variant	508	1	Q → R. Corresponds to variant rs7264544 [ dbSNP | Ensembl ].		VAR_053867

Sequences

	Sequence		Length	Mass (Da)
	Q96KK3 [UniParc]. Last modified March 1, 2002. Version 2. Checksum: 00F0E415E3A68C91	FASTA	526	58,372
	10 20 30 40 50 60 MLMLLVRGTH YENLRSKVVL PTPLGGRSTE TFVSEFPGPD TGIRWRRSDE ALRVNVGGVR 70 80 90 100 110 120 RQLSARALAR FPGTRLGRLQ AAASEEQARR LCDDYDEAAR EFYFDRHPGF FLSLLHFYRT 130 140 150 160 170 180 GHLHVLDELC VFAFGQEADY WGLGENALAA CCRARYLERR LTQPHAWDED SDTPSSVDPC 190 200 210 220 230 240 PDEISDVQRE LARYGAARCG RLRRRLWLTM ENPGYSLPSK LFSCVSISVV LASIAAMCIH 250 260 270 280 290 300 SLPEYQAREA AAAVAAVAAG RSPEGVRDDP VLRRLEYFCI AWFSFEVSSR LLLAPSTRNF 310 320 330 340 350 360 FCHPLNLIDI VSVLPFYLTL LAGVALGDQG GKEFGHLGKV VQVFRLMRIF RVLKLARHST 370 380 390 400 410 420 GLRSLGATLK HSYREVGILL LYLAVGVSVF SGVAYTAEKE EDVGFNTIPA CWWWGTVSMT 430 440 450 460 470 480 TVGYGDVVPV TVAGKLAASG CILGGILVVA LPITIIFNKF SHFYRRQKAL EAAVRNSNHQ 490 500 510 520 EFEDLLSSID GVSEASLETS RETSQEGQSA DLESQAPSEP PHPQMY

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Electrically silent potassium channel subunits from human lens epithelium." Shepard A.R., Rae J.L. Am. J. Physiol. 277:C412-C424(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Brain and Lens epithelium.
[2]	"The DNA sequence and comparative analysis of human chromosome 20." Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E. , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J. Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT VAL-489. Tissue: Brain.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF043473 mRNA. Translation: AAC13165.2. Z93016 Genomic DNA. Translation: CAB07507.2. BC075033 mRNA. Translation: AAH75033.2. BC075034 mRNA. Translation: AAH75034.2. BC132959 mRNA. Translation: AAI32960.1. BC144234 mRNA. Translation: AAI44235.1.
IPI	IPI00102065.
RefSeq	NP_002242.2. NM_002251.3.
UniGene	Hs.117780.
3D structure databases
ProteinModelPortal	Q96KK3.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000307694.
Protein family/group databases
TCDB	1.A.1.2.7. voltage-gated ion channel (VIC) superfamily.
PTM databases
PhosphoSite	Q96KK3.
Polymorphism databases
DMDM	24418474.
Proteomic databases
PaxDb	Q96KK3.
PRIDE	Q96KK3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000306117; ENSP00000307694; ENSG00000124134. ENST00000537075; ENSP00000445595; ENSG00000124134.
GeneID	3787.
KEGG	hsa:3787.
UCSC	uc002xnc.3. human.
Organism-specific databases
CTD	3787.
GeneCards	GC20M043720.
HGNC	HGNC:6300. KCNS1.
MIM	602905. gene.
neXtProt	NX_Q96KK3.
PharmGKB	PA30078.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG1226.
HOGENOM	HOG000231016.
HOVERGEN	HBG052230.
InParanoid	Q96KK3.
KO	K04931.
OMA	FSCVSIS.
OrthoDB	EOG4NS3B8.
Enzyme and pathway databases
Reactome	REACT_13685. Neuronal System.
Gene expression databases
ArrayExpress	Q96KK3.
Bgee	Q96KK3.
CleanEx	HS_KCNS1.
Genevestigator	Q96KK3.
GermOnline	ENSG00000124134. Homo sapiens.
Family and domain databases
Gene3D	3.30.710.10. 1 hit.
InterPro	IPR000210. BTB/POZ-like. IPR011333. BTB/POZ_fold. IPR005821. Ion_trans_dom. IPR003091. K_chnl. IPR003968. K_chnl_volt-dep_Kv. IPR003971. K_chnl_volt-dep_Kv9. IPR003131. T1-type_BTB. [Graphical view]
PANTHER	PTHR11537. PTHR11537. 1 hit.
Pfam	PF00520. Ion_trans. 1 hit. PF02214. K_tetra. 1 hit. [Graphical view]
PRINTS	PR00169. KCHANNEL. PR01494. KV9CHANNEL. PR01491. KVCHANNEL.
SMART	SM00225. BTB. 1 hit. [Graphical view]
SUPFAM	SSF54695. BTB/POZ_fold. 1 hit.
ProtoNet	Search...
Other
GenomeRNAi	3787.
NextBio	14875.
SOURCE	Search...

Entry information

Entry name

KCNS1_HUMAN

Accession

Primary (citable) accession number: Q96KK3
Secondary accession number(s): A2RUL9 , B7ZM31, O43652, Q6DJU6

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 25, 2002
Last sequence update:	March 1, 2002
Last modified:	May 1, 2013
This is version 98 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.