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Protein

Potassium voltage-gated channel subfamily S member 1

Gene

KCNS1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Potassium channel subunit that does not form functional channels by itself. Can form functional heterotetrameric channels with KCNB1 and KCNB2; modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1 and KCNB2 (PubMed:10484328).1 Publication

GO - Molecular functioni

  • delayed rectifier potassium channel activity Source: UniProtKB
  • potassium channel regulator activity Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Potassium channel, Voltage-gated channel

Keywords - Biological processi

Ion transport, Potassium transport, Transport

Keywords - Ligandi

Potassium

Enzyme and pathway databases

ReactomeiR-HSA-1296072. Voltage gated Potassium channels.

Protein family/group databases

TCDBi1.A.1.2.7. the voltage-gated ion channel (vic) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium voltage-gated channel subfamily S member 1
Alternative name(s):
Delayed-rectifier K(+) channel alpha subunit 1
Voltage-gated potassium channel subunit Kv9.1
Gene namesi
Name:KCNS1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

HGNCiHGNC:6300. KCNS1.

Subcellular locationi

  • Cell membrane 1 Publication; Multi-pass membrane protein Curated

  • Note: May not reach the plasma membrane but remain in an intracellular compartment in the absence of KCNB1 or KCNB2 (PubMed:10484328).1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 217217CytoplasmicBy similarityAdd
BLAST
Transmembranei218 – 23922Helical; Name=Segment S1By similarityAdd
BLAST
Topological domaini240 – 27031ExtracellularBy similarityAdd
BLAST
Transmembranei271 – 29323Helical; Name=Segment S2By similarityAdd
BLAST
Topological domaini294 – 30411CytoplasmicBy similarityAdd
BLAST
Transmembranei305 – 32218Helical; Name=Segment S3By similarityAdd
BLAST
Topological domaini323 – 33715ExtracellularBy similarityAdd
BLAST
Transmembranei338 – 35821Helical; Voltage-sensor; Name=Segment S4By similarityAdd
BLAST
Topological domaini359 – 37315CytoplasmicBy similarityAdd
BLAST
Transmembranei374 – 39522Helical; Name=Segment S5By similarityAdd
BLAST
Topological domaini396 – 40813ExtracellularBy similarityAdd
BLAST
Intramembranei409 – 42012Helical; Name=Pore helixBy similarityAdd
BLAST
Intramembranei421 – 4288By similarity
Topological domaini429 – 4357ExtracellularBy similarity
Transmembranei436 – 46429Helical; Name=Segment S6By similarityAdd
BLAST
Topological domaini465 – 52662CytoplasmicBy similarityAdd
BLAST

GO - Cellular componenti

  • perinuclear region of cytoplasm Source: UniProtKB
  • plasma membrane Source: UniProtKB
  • voltage-gated potassium channel complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30078.

Chemistry

ChEMBLiCHEMBL2362996.

Polymorphism and mutation databases

BioMutaiKCNS1.
DMDMi24418474.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 526526Potassium voltage-gated channel subfamily S member 1PRO_0000054081Add
BLAST

Proteomic databases

PaxDbiQ96KK3.
PRIDEiQ96KK3.

PTM databases

iPTMnetiQ96KK3.
PhosphoSiteiQ96KK3.

Expressioni

Tissue specificityi

Detected in all tissues tested with the exception of skeletal muscle. Highly expressed in adult and fetal brain, fetal kidney and lung, and adult prostate and testis (PubMed:10484328).1 Publication

Gene expression databases

BgeeiENSG00000124134.
CleanExiHS_KCNS1.
ExpressionAtlasiQ96KK3. baseline and differential.
GenevisibleiQ96KK3. HS.

Interactioni

Subunit structurei

Heterotetramer with KCNB1 (PubMed:10484328). Heterotetramer with KCNB2 (By similarity). Does not form homomultimers (PubMed:10484328).By similarity1 Publication

Protein-protein interaction databases

STRINGi9606.ENSP00000307694.

Structurei

3D structure databases

ProteinModelPortaliQ96KK3.
SMRiQ96KK3. Positions 50-467.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi421 – 4266Selectivity filterBy similarity

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi250 – 25910Poly-Ala

Domaini

The transmembrane segment S4 functions as voltage-sensor and is characterized by a series of positively charged amino acids at every third position. Channel opening and closing is effected by a conformation change that affects the position and orientation of the voltage-sensor paddle formed by S3 and S4 within the membrane. A transmembrane electric field that is positive inside would push the positively charged S4 segment outwards, thereby opening the pore, while a field that is negative inside would pull the S4 segment inwards and close the pore. Changes in the position and orientation of S4 are then transmitted to the activation gate formed by the inner helix bundle via the S4-S5 linker region.By similarity

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3713. Eukaryota.
COG1226. LUCA.
GeneTreeiENSGT00760000118981.
HOGENOMiHOG000231016.
HOVERGENiHBG052230.
InParanoidiQ96KK3.
KOiK04931.
OMAiWLTLENP.
OrthoDBiEOG091G0FP3.
PhylomeDBiQ96KK3.
TreeFamiTF313103.

Family and domain databases

Gene3Di1.20.120.350. 1 hit.
InterProiIPR000210. BTB/POZ_dom.
IPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR003968. K_chnl_volt-dep_Kv.
IPR003971. K_chnl_volt-dep_Kv9.
IPR011333. SKP1/BTB/POZ.
IPR003131. T1-type_BTB.
IPR028325. VG_K_chnl.
[Graphical view]
PANTHERiPTHR11537. PTHR11537. 1 hit.
PfamiPF02214. BTB_2. 1 hit.
PF00520. Ion_trans. 1 hit.
[Graphical view]
PRINTSiPR00169. KCHANNEL.
PR01494. KV9CHANNEL.
PR01491. KVCHANNEL.
SMARTiSM00225. BTB. 1 hit.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.

Sequencei

Sequence statusi: Complete.

Q96KK3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLMLLVRGTH YENLRSKVVL PTPLGGRSTE TFVSEFPGPD TGIRWRRSDE
60 70 80 90 100
ALRVNVGGVR RQLSARALAR FPGTRLGRLQ AAASEEQARR LCDDYDEAAR
110 120 130 140 150
EFYFDRHPGF FLSLLHFYRT GHLHVLDELC VFAFGQEADY WGLGENALAA
160 170 180 190 200
CCRARYLERR LTQPHAWDED SDTPSSVDPC PDEISDVQRE LARYGAARCG
210 220 230 240 250
RLRRRLWLTM ENPGYSLPSK LFSCVSISVV LASIAAMCIH SLPEYQAREA
260 270 280 290 300
AAAVAAVAAG RSPEGVRDDP VLRRLEYFCI AWFSFEVSSR LLLAPSTRNF
310 320 330 340 350
FCHPLNLIDI VSVLPFYLTL LAGVALGDQG GKEFGHLGKV VQVFRLMRIF
360 370 380 390 400
RVLKLARHST GLRSLGATLK HSYREVGILL LYLAVGVSVF SGVAYTAEKE
410 420 430 440 450
EDVGFNTIPA CWWWGTVSMT TVGYGDVVPV TVAGKLAASG CILGGILVVA
460 470 480 490 500
LPITIIFNKF SHFYRRQKAL EAAVRNSNHQ EFEDLLSSID GVSEASLETS
510 520
RETSQEGQSA DLESQAPSEP PHPQMY
Length:526
Mass (Da):58,372
Last modified:March 1, 2002 - v2
Checksum:i00F0E415E3A68C91
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti489 – 4891I → V.1 Publication
Corresponds to variant rs734784 [ dbSNP | Ensembl ].
VAR_020052
Natural varianti508 – 5081Q → R.
Corresponds to variant rs7264544 [ dbSNP | Ensembl ].
VAR_053867

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF043473 mRNA. Translation: AAC13165.2.
Z93016 Genomic DNA. Translation: CAB07507.2.
BC075033 mRNA. Translation: AAH75033.2.
BC075034 mRNA. Translation: AAH75034.2.
BC132959 mRNA. Translation: AAI32960.1.
BC144234 mRNA. Translation: AAI44235.1.
CCDSiCCDS13342.1.
RefSeqiNP_001309728.1. NM_001322799.1.
NP_002242.2. NM_002251.4.
UniGeneiHs.117780.
Hs.563002.

Genome annotation databases

EnsembliENST00000306117; ENSP00000307694; ENSG00000124134.
ENST00000537075; ENSP00000445595; ENSG00000124134.
GeneIDi3787.
KEGGihsa:3787.
UCSCiuc002xnc.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF043473 mRNA. Translation: AAC13165.2.
Z93016 Genomic DNA. Translation: CAB07507.2.
BC075033 mRNA. Translation: AAH75033.2.
BC075034 mRNA. Translation: AAH75034.2.
BC132959 mRNA. Translation: AAI32960.1.
BC144234 mRNA. Translation: AAI44235.1.
CCDSiCCDS13342.1.
RefSeqiNP_001309728.1. NM_001322799.1.
NP_002242.2. NM_002251.4.
UniGeneiHs.117780.
Hs.563002.

3D structure databases

ProteinModelPortaliQ96KK3.
SMRiQ96KK3. Positions 50-467.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000307694.

Chemistry

ChEMBLiCHEMBL2362996.

Protein family/group databases

TCDBi1.A.1.2.7. the voltage-gated ion channel (vic) superfamily.

PTM databases

iPTMnetiQ96KK3.
PhosphoSiteiQ96KK3.

Polymorphism and mutation databases

BioMutaiKCNS1.
DMDMi24418474.

Proteomic databases

PaxDbiQ96KK3.
PRIDEiQ96KK3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000306117; ENSP00000307694; ENSG00000124134.
ENST00000537075; ENSP00000445595; ENSG00000124134.
GeneIDi3787.
KEGGihsa:3787.
UCSCiuc002xnc.4. human.

Organism-specific databases

CTDi3787.
GeneCardsiKCNS1.
HGNCiHGNC:6300. KCNS1.
MIMi602905. gene.
neXtProtiNX_Q96KK3.
PharmGKBiPA30078.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3713. Eukaryota.
COG1226. LUCA.
GeneTreeiENSGT00760000118981.
HOGENOMiHOG000231016.
HOVERGENiHBG052230.
InParanoidiQ96KK3.
KOiK04931.
OMAiWLTLENP.
OrthoDBiEOG091G0FP3.
PhylomeDBiQ96KK3.
TreeFamiTF313103.

Enzyme and pathway databases

ReactomeiR-HSA-1296072. Voltage gated Potassium channels.

Miscellaneous databases

GeneWikiiKCNS1.
GenomeRNAii3787.
PROiQ96KK3.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000124134.
CleanExiHS_KCNS1.
ExpressionAtlasiQ96KK3. baseline and differential.
GenevisibleiQ96KK3. HS.

Family and domain databases

Gene3Di1.20.120.350. 1 hit.
InterProiIPR000210. BTB/POZ_dom.
IPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR003968. K_chnl_volt-dep_Kv.
IPR003971. K_chnl_volt-dep_Kv9.
IPR011333. SKP1/BTB/POZ.
IPR003131. T1-type_BTB.
IPR028325. VG_K_chnl.
[Graphical view]
PANTHERiPTHR11537. PTHR11537. 1 hit.
PfamiPF02214. BTB_2. 1 hit.
PF00520. Ion_trans. 1 hit.
[Graphical view]
PRINTSiPR00169. KCHANNEL.
PR01494. KV9CHANNEL.
PR01491. KVCHANNEL.
SMARTiSM00225. BTB. 1 hit.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiKCNS1_HUMAN
AccessioniPrimary (citable) accession number: Q96KK3
Secondary accession number(s): A2RUL9
, B7ZM31, O43652, Q6DJU6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 25, 2002
Last sequence update: March 1, 2002
Last modified: September 7, 2016
This is version 127 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.