Reviewed, UniProtKB/Swiss-Prot Q96KJ9 (COX42_HUMAN)

Names and origin

Protein names

Recommended name:
    Cytochrome c oxidase subunit 4 isoform 2, mitochondrial
Alternative name(s):
    Cytochrome c oxidase subunit IV isoform 2
      Short name=COX IV-2

Gene names

Name:	COX4I2
Synonyms:	COX4L2

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	171 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.
Subcellular location	Mitochondrion inner membrane.
Tissue specificity	Highly expressed in lung.
Sequence similarities	Belongs to the cytochrome c oxidase IV family.

Ontologies

Keywords
Cellular component	Membrane Mitochondrion Mitochondrion inner membrane
Coding sequence diversity	Polymorphism
Domain	Transit peptide
PTM	Disulfide bond
Gene Ontology (GO)
Biological process	cellular respiration Non-traceable author statement. Source: UniProtKB oxidation reduction Ref.1 Non-traceable author statement. Source: UniProtKB
Cellular component	mitochondrial respiratory chain complex IV Ref.1 Inferred by curator. Source: UniProtKB
Molecular function	cytochrome-c oxidase activity Ref.1 Inferred from direct assay. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Transit peptide	1 – ?		Mitochondrion Potential
	Chain	? – 171		Cytochrome c oxidase subunit 4 isoform 2, mitochondrial		PRO_0000006089
Amino acid modifications
	Disulfide bond	40 ↔ 54		Potential
Natural variations
	Natural variant	161	1	R → H: dbSNP rs11907253. Ref.1		VAR_033815

Sequences

	Sequence		Length	Mass (Da)
	Q96KJ9-1 [UniParc]. Last modified August 16, 2005. Version 2. Checksum: CD9BC8EC6EA3F4A3	FASTA	171	20,010
	10 20 30 40 50 60 MLPRAAWSLV LRKGGGGRRG MHSSEGTTRG GGKMSPYTNC YAQRYYPMPE EPFCTELNAE 70 80 90 100 110 120 EQALKEKEKG SWTQLTHAEK VALYRLQFNE TFAEMNRRSN EWKTVMGCVF FFIGFAALVI 130 140 150 160 170 WWQRVYVFPP KPITLTDERK AQQLQRMLDM KVNPVQGLAS RWDYEKKQWK K

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Mammalian subunit IV isoforms of cytochrome c oxidase." Huettemann M., Kadenbach B., Grossman L.I. Gene 267:111-123(2001) [PubMed: 11311561] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT HIS-161.
[2]	"The DNA sequence and comparative analysis of human chromosome 20." Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E. , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J. Nature 414:865-871(2001) [PubMed: 11780052] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Placenta.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF257180 mRNA. Translation: AAK49333.1. AL117381 Genomic DNA. Translation: CAI23028.1. BC057779 mRNA. Translation: AAH57779.1.
IPI	IPI00064655.
RefSeq	NP_115998.2.
UniGene	Hs.277101
3D structure databases
ModBase	Search...
Protein family/group databases
TCDB	3.D.4.11.1. proton-translocating cytochrome oxidase (COX) superfamily.
Genome annotation databases
Ensembl	ENSG00000131055. Homo sapiens. [Contig view]
GeneID	84701.
KEGG	hsa:84701.
Organism-specific databases
GeneCards	GC20P029689.
HGNC	HGNC:16232. COX4I2.
MIM	607976. gene.
PharmGKB	PA26783.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	Q96KJ9.
HOVERGEN	Q96KJ9.
OMA	Q96KJ9. GKMPPYT.
Gene expression databases
ArrayExpress	Q96KJ9.
Bgee	Q96KJ9.
CleanEx	HS_COX4I2.
GermOnline	ENSG00000131055. Homo sapiens.
Family and domain databases
InterPro	IPR004203. Cyt_c_oxidase_su4. IPR013288. Cyt_c_oxidase_su4_sub. [Graphical view]
Gene3D	G3DSA:1.10.442.10. COX4. 1 hit.
Pfam	PF02936. COX4. 1 hit. [Graphical view]
PRINTS	PR01873. CYTCOXIDASE4.
ProtoNet	Search...
Other Resources
NextBio	74788.
SOURCE	Search...

Entry information

Entry name

COX42_HUMAN

Accession

Primary (citable) accession number: Q96KJ9
Secondary accession number(s): Q6GTF4, Q9H0Z4

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 3, 2002
Last sequence update:	August 16, 2005
Last modified:	June 16, 2009
This is version 63 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)