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Q96KG9

- NTKL_HUMAN

UniProt

Q96KG9 - NTKL_HUMAN

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Protein
N-terminal kinase-like protein
Gene
SCYL1, CVAK90, GKLP, NTKL, TAPK, TEIF, TRAP, HT019
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Regulates COPI-mediated retrograde traffic. Has no detectable kinase activity in vitro.2 Publications
Isoform 6 acts as transcriptional activator. It binds to three different types of GC-rich DNA binding sites (box-A, -B and -C) in the beta-polymerase promoter region. It also binds to the TERT promoter region.2 Publications

GO - Molecular functioni

  1. ATP binding Source: InterPro
  2. DNA binding Source: UniProtKB-KW
  3. protein tyrosine kinase activity Source: UniProtKB

GO - Biological processi

  1. peptidyl-tyrosine phosphorylation Source: GOC
  2. regulation of transcription, DNA-templated Source: UniProtKB-KW
  3. retrograde vesicle-mediated transport, Golgi to ER Source: UniProtKB
  4. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

ER-Golgi transport, Transcription, Transcription regulation, Transport

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

SignaLinkiQ96KG9.

Names & Taxonomyi

Protein namesi
Recommended name:
N-terminal kinase-like protein
Alternative name(s):
Coated vesicle-associated kinase of 90 kDa
SCY1-like protein 1
Telomerase regulation-associated protein
Telomerase transcriptional element-interacting factor
Teratoma-associated tyrosine kinase
Gene namesi
Name:SCYL1
Synonyms:CVAK90, GKLP, NTKL, TAPK, TEIF, TRAP
ORF Names:HT019
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:14372. SCYL1.

Subcellular locationi

Cytoplasmcytoskeletonmicrotubule organizing centercentrosome. Endoplasmic reticulum-Golgi intermediate compartment. Golgi apparatuscis-Golgi network
Note: Localized to the Endoplasmic reticulum-Golgi intermediate and cis-Golgi in an ARF1-independent manner.2 Publications
Isoform 1 : Cytoplasm
Note: Cytoplasmic throughout the cell cycle.2 Publications
Isoform 2 : Cytoplasm
Note: Cytoplasmic throughout the cell cycle.2 Publications
Isoform 3 : Cytoplasm. Cytoplasmcytoskeletonmicrotubule organizing centercentrosome
Note: Cytoplasmic during interphase and centrosomal during mitosis, it localizes to the centrosomes in a microtubule-independent manner.2 Publications
Isoform 6 : Nucleus 2 Publications

GO - Cellular componenti

  1. COPI vesicle coat Source: UniProtKB
  2. Golgi apparatus Source: UniProtKB
  3. cis-Golgi network Source: UniProtKB
  4. cytoplasm Source: HGNC
  5. endoplasmic reticulum-Golgi intermediate compartment Source: UniProtKB
  6. microtubule organizing center Source: UniProtKB-SubCell
  7. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Golgi apparatus, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31812.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 808808N-terminal kinase-like protein
PRO_0000249541Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei754 – 7541Phosphoserine2 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ96KG9.
PaxDbiQ96KG9.
PRIDEiQ96KG9.

PTM databases

PhosphoSiteiQ96KG9.

Expressioni

Tissue specificityi

Ubiquitous.1 Publication

Gene expression databases

ArrayExpressiQ96KG9.
BgeeiQ96KG9.
CleanExiHS_SCYL1.
GenevestigatoriQ96KG9.

Organism-specific databases

HPAiHPA015015.

Interactioni

Subunit structurei

Interacts with GORAB. Interacts with COPA, COPB1 and COPB2 By similarity. Homooligomer. Interacts with AP2B1.2 Publications

Protein-protein interaction databases

BioGridi121512. 10 interactions.
IntActiQ96KG9. 9 interactions.
MINTiMINT-3055065.
STRINGi9606.ENSP00000270176.

Structurei

3D structure databases

ProteinModelPortaliQ96KG9.
SMRiQ96KG9. Positions 29-526.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini14 – 314301Protein kinase
Add
BLAST
Repeati350 – 38839HEAT 1
Add
BLAST
Repeati389 – 42739HEAT 2
Add
BLAST
Repeati507 – 54539HEAT 3
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni793 – 80816Interaction with COPB1 By similarity
Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili761 – 79737 Reviewed prediction
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi589 – 61931Pro-rich
Add
BLAST

Domaini

The protein kinase domain is predicted to be catalytically inactive.

Sequence similaritiesi

Contains 3 HEAT repeats.

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

eggNOGiNOG293900.
HOVERGENiHBG082065.
InParanoidiQ96KG9.
KOiK08876.
OMAiQEDWSTG.
OrthoDBiEOG7RJPQX.
PhylomeDBiQ96KG9.
TreeFamiTF313435.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]

Sequences (6)i

Sequence statusi: Complete.

This entry describes 6 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q96KG9-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MWFFARDPVR DFPFELIPEP PEGGLPGPWA LHRGRKKATG SPVSIFVYDV    50
KPGAEEQTQV AKAAFKRFKT LRHPNILAYI DGLETEKCLH VVTEAVTPLG 100
IYLKARVEAG GLKELEISWG LHQIVKALSF LVNDCSLIHN NVCMAAVFVD 150
RAGEWKLGGL DYMYSAQGNG GGPPRKGIPE LEQYDPPELA DSSGRVVREK 200
WSADMWRLGC LIWEVFNGPL PRAAALRNPG KIPKTLVPHY CELVGANPKV 250
RPNPARFLQN CRAPGGFMSN RFVETNLFLE EIQIKEPAEK QKFFQELSKS 300
LDAFPEDFCR HKVLPQLLTA FEFGNAGAVV LTPLFKVGKF LSAEEYQQKI 350
IPVVVKMFSS TDRAMRIRLL QQMEQFIQYL DEPTVNTQIF PHVVHGFLDT 400
NPAIREQTVK SMLLLAPKLN EANLNVELMK HFARLQAKDE QGPIRCNTTV 450
CLGKIGSYLS ASTRHRVLTS AFSRATRDPF APSRVAGVLG FAATHNLYSM 500
NDCAQKILPV LCGLTVDPEK SVRDQAFKAI RSFLSKLESV SEDPTQLEEV 550
EKDVHAASSP GMGGAAASWA GWAVTGVSSL TSKLIRSHPT TAPTETNIPQ 600
RPTPEGVPAP APTPVPATPT TSGHWETQEE DKDTAEDSST ADRWDDEDWG 650
SLEQEAESVL AQQDDWSTGG QVSRASQVSN SDHKSSKSPE SDWSSWEAEG 700
SWEQGWQEPS SQEPPPDGTR LASEYNWGGP ESSDKGDPFA TLSARPSTQP 750
RPDSWGEDNW EGLETDSRQV KAELARKKRE ERRREMEAKR AERKVAKGPM 800
KLGARKLD 808
Length:808
Mass (Da):89,631
Last modified:December 1, 2001 - v1
Checksum:iE87A2957DDCCE937
GO
Isoform 2 (identifier: Q96KG9-2) [UniParc]FASTAAdd to Basket

Also known as: Variant 1

The sequence of this isoform differs from the canonical sequence as follows:
     606-622: Missing.

Show »
Length:791
Mass (Da):88,089
Checksum:i79A8FA462666CBC5
GO
Isoform 3 (identifier: Q96KG9-3) [UniParc]FASTAAdd to Basket

Also known as: Variant 2

The sequence of this isoform differs from the canonical sequence as follows:
     606-622: Missing.
     628-711: Missing.

Note: Non-canonical splice junctions.

Show »
Length:707
Mass (Da):78,696
Checksum:i2F2C81CD4EAF8225
GO
Isoform 4 (identifier: Q96KG9-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     750-808: PRPDSWGEDN...PMKLGARKLD → DRSRLSWPGRSARSGGGRWRPNAPRGRWPRAP

Show »
Length:781
Mass (Da):86,312
Checksum:i7DC90CF2578622FE
GO
Isoform 5 (identifier: Q96KG9-5) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     603-626: TPEGVPAPAPTPVPATPTTSGHWE → SRPARRPLGDAGGGQGHSRGQQHC
     627-808: Missing.

Show »
Length:626
Mass (Da):69,238
Checksum:i43E36C7298D8BB33
GO
Isoform 6 (identifier: Q96KG9-6) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     678-808: VSNSDHKSSK...PMKLGARKLD → SPTGAAGKLR...APRGRWPRAP

Show »
Length:787
Mass (Da):86,371
Checksum:iBD673D007B1A79B9
GO

Sequence cautioni

The sequence AAG09726.1 differs from that shown. Reason: Frameshift at positions 289 and 307.
The sequence AAG17902.1 differs from that shown. Reason: Frameshift at several positions.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti479 – 4791P → L.1 Publication
Corresponds to variant rs55977709 [ dbSNP | Ensembl ].
VAR_041364
Natural varianti495 – 4951H → Y in a metastatic melanoma sample; somatic mutation. 1 Publication
VAR_041365
Natural varianti663 – 6631Q → H.1 Publication
Corresponds to variant rs56076708 [ dbSNP | Ensembl ].
VAR_041366
Natural varianti755 – 7551W → S.1 Publication
Corresponds to variant rs56077405 [ dbSNP | Ensembl ].
VAR_041367

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei603 – 62624TPEGV…SGHWE → SRPARRPLGDAGGGQGHSRG QQHC in isoform 5.
VSP_020503Add
BLAST
Alternative sequencei606 – 62217Missing in isoform 2 and isoform 3.
VSP_020504Add
BLAST
Alternative sequencei627 – 808182Missing in isoform 5.
VSP_020505Add
BLAST
Alternative sequencei628 – 71184Missing in isoform 3.
VSP_020506Add
BLAST
Alternative sequencei678 – 808131VSNSD…ARKLD → SPTGAAGKLRAPGNRAGRSQ APRSHLLTVHGWPASITGVA QSPATRATPSLPCLHVPAPS RGQTLGVRTTGRASRLTVDR SRLSWPGRSARSGGGRWRPN APRGRWPRAP in isoform 6.
VSP_020507Add
BLAST
Alternative sequencei750 – 80859PRPDS…ARKLD → DRSRLSWPGRSARSGGGRWR PNAPRGRWPRAP in isoform 4.
VSP_020508Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti168 – 1692GN → AT in AAG17902. 1 Publication
Sequence conflicti530 – 5301I → F in AAG09726. 1 Publication
Sequence conflicti574 – 5741V → W in AAG09726. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB047077 mRNA. Translation: BAB55454.1.
AB051427 mRNA. Translation: BAB55458.1.
AB051428 mRNA. Translation: BAB55459.1.
AF297709 mRNA. Translation: AAG17902.1. Frameshift.
AP000769 Genomic DNA. No translation available.
CH471076 Genomic DNA. Translation: EAW74399.1.
BC009967 mRNA. Translation: AAH09967.2.
BC069233 mRNA. Translation: AAH69233.1.
AF255613 Genomic DNA. Translation: AAF81422.1.
AF225424 mRNA. Translation: AAG09726.1. Frameshift.
CCDSiCCDS41672.1. [Q96KG9-1]
CCDS44646.1. [Q96KG9-2]
RefSeqiNP_001041683.1. NM_001048218.1. [Q96KG9-2]
NP_065731.3. NM_020680.3. [Q96KG9-1]
XP_005274177.1. XM_005274120.1. [Q96KG9-4]
UniGeneiHs.238839.

Genome annotation databases

EnsembliENST00000270176; ENSP00000270176; ENSG00000142186. [Q96KG9-1]
ENST00000279270; ENSP00000279270; ENSG00000142186. [Q96KG9-4]
ENST00000420247; ENSP00000408192; ENSG00000142186. [Q96KG9-2]
ENST00000533862; ENSP00000437254; ENSG00000142186. [Q96KG9-6]
GeneIDi57410.
KEGGihsa:57410.
UCSCiuc001oea.1. human. [Q96KG9-1]
uc001oeb.1. human. [Q96KG9-2]
uc001oec.1. human. [Q96KG9-6]
uc001oee.1. human. [Q96KG9-4]

Polymorphism databases

DMDMi74762671.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB047077 mRNA. Translation: BAB55454.1 .
AB051427 mRNA. Translation: BAB55458.1 .
AB051428 mRNA. Translation: BAB55459.1 .
AF297709 mRNA. Translation: AAG17902.1 . Frameshift.
AP000769 Genomic DNA. No translation available.
CH471076 Genomic DNA. Translation: EAW74399.1 .
BC009967 mRNA. Translation: AAH09967.2 .
BC069233 mRNA. Translation: AAH69233.1 .
AF255613 Genomic DNA. Translation: AAF81422.1 .
AF225424 mRNA. Translation: AAG09726.1 . Frameshift.
CCDSi CCDS41672.1. [Q96KG9-1 ]
CCDS44646.1. [Q96KG9-2 ]
RefSeqi NP_001041683.1. NM_001048218.1. [Q96KG9-2 ]
NP_065731.3. NM_020680.3. [Q96KG9-1 ]
XP_005274177.1. XM_005274120.1. [Q96KG9-4 ]
UniGenei Hs.238839.

3D structure databases

ProteinModelPortali Q96KG9.
SMRi Q96KG9. Positions 29-526.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 121512. 10 interactions.
IntActi Q96KG9. 9 interactions.
MINTi MINT-3055065.
STRINGi 9606.ENSP00000270176.

PTM databases

PhosphoSitei Q96KG9.

Polymorphism databases

DMDMi 74762671.

Proteomic databases

MaxQBi Q96KG9.
PaxDbi Q96KG9.
PRIDEi Q96KG9.

Protocols and materials databases

DNASUi 57410.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000270176 ; ENSP00000270176 ; ENSG00000142186 . [Q96KG9-1 ]
ENST00000279270 ; ENSP00000279270 ; ENSG00000142186 . [Q96KG9-4 ]
ENST00000420247 ; ENSP00000408192 ; ENSG00000142186 . [Q96KG9-2 ]
ENST00000533862 ; ENSP00000437254 ; ENSG00000142186 . [Q96KG9-6 ]
GeneIDi 57410.
KEGGi hsa:57410.
UCSCi uc001oea.1. human. [Q96KG9-1 ]
uc001oeb.1. human. [Q96KG9-2 ]
uc001oec.1. human. [Q96KG9-6 ]
uc001oee.1. human. [Q96KG9-4 ]

Organism-specific databases

CTDi 57410.
GeneCardsi GC11P065292.
HGNCi HGNC:14372. SCYL1.
HPAi HPA015015.
MIMi 607982. gene.
neXtProti NX_Q96KG9.
PharmGKBi PA31812.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG293900.
HOVERGENi HBG082065.
InParanoidi Q96KG9.
KOi K08876.
OMAi QEDWSTG.
OrthoDBi EOG7RJPQX.
PhylomeDBi Q96KG9.
TreeFami TF313435.

Enzyme and pathway databases

SignaLinki Q96KG9.

Miscellaneous databases

ChiTaRSi SCYL1. human.
GeneWikii SCYL1.
GenomeRNAii 57410.
NextBioi 63536.
PROi Q96KG9.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q96KG9.
Bgeei Q96KG9.
CleanExi HS_SCYL1.
Genevestigatori Q96KG9.

Family and domain databases

Gene3Di 1.25.10.10. 1 hit.
InterProi IPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
[Graphical view ]
Pfami PF00069. Pkinase. 1 hit.
[Graphical view ]
SUPFAMi SSF48371. SSF48371. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEi PS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification and characterization of the human protein kinase-like gene NTKL: mitosis-specific centrosomal localization of an alternatively spliced isoform."
    Kato M., Yano K., Morotomi-Yano K., Saito H., Miki Y.
    Genomics 79:760-767(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3), SUBUNIT, TISSUE SPECIFICITY.
    Tissue: Testis.
  2. "Molecular cloning and characterization of a human gene involved in transcriptional regulation of hTERT."
    Tang Z., Zhao Y., Mei F., Yang S., Li X., Lv J., Hou L., Zhang B.
    Biochem. Biophys. Res. Commun. 324:1324-1332(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 6), DNA-BINDING (ISOFORM 6), SUBCELLULAR LOCATION (ISOFORM 6).
    Tissue: Cervix carcinoma.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 310-808 (ISOFORM 4).
    Tissue: Eye and Teratocarcinoma.
  6. "Construction of a 350-kb sequence-ready 11q13 cosmid contig encompassing the markers D11S4933 and D11S546: mapping of 11 genes and 3 tumor-associated translocation breakpoints."
    van Asseldonk M., Schepens M., de Bruijn D., Janssen B., Merkx G., Geurts van Kessel A.
    Genomics 66:35-42(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-283.
  7. Xiao H., Song H., Gao G., Ren S., Chen Z., Han Z.
    Submitted (JAN-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 288-808 (ISOFORM 5).
    Tissue: Hypothalamus.
  8. "Transcriptional upregulation of DNA polymerase beta by TEIF."
    Zhao Y., Zheng J., Ling Y., Hou L., Zhang B.
    Biochem. Biophys. Res. Commun. 333:908-916(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION (ISOFORM 6), DNA-BINDING (ISOFORM 6).
  9. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
    Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
    Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-754, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  10. "Role of the AP2 beta-appendage hub in recruiting partners for clathrin-coated vesicle assembly."
    Schmid E.M., Ford M.G.J., Burtey A., Praefcke G.J.K., Peak-Chew S.-Y., Mills I.G., Benmerah A., McMahon H.T.
    PLoS Biol. 4:E262-E262(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH AP2B1.
  11. "Scyl1, mutated in a recessive form of spinocerebellar neurodegeneration, regulates COPI-mediated retrograde traffic."
    Burman J.L., Bourbonniere L., Philie J., Stroh T., Dejgaard S.Y., Presley J.F., McPherson P.S.
    J. Biol. Chem. 283:22774-22786(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.
  12. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-754, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  13. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  14. "Patterns of somatic mutation in human cancer genomes."
    Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G.
    , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.
    Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS [LARGE SCALE ANALYSIS] LEU-479; TYR-495; HIS-663 AND SER-755.

Entry informationi

Entry nameiNTKL_HUMAN
AccessioniPrimary (citable) accession number: Q96KG9
Secondary accession number(s): A6NJF1
, Q96G50, Q96KG8, Q96KH1, Q9HAW5, Q9HBL3, Q9NR53
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2006
Last sequence update: December 1, 2001
Last modified: July 9, 2014
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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