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Q96KG9

- NTKL_HUMAN

UniProt

Q96KG9 - NTKL_HUMAN

Protein

N-terminal kinase-like protein

Gene

SCYL1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
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    • History
      Entry version 118 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    Regulates COPI-mediated retrograde traffic. Has no detectable kinase activity in vitro.1 Publication
    Isoform 6 acts as transcriptional activator. It binds to three different types of GC-rich DNA binding sites (box-A, -B and -C) in the beta-polymerase promoter region. It also binds to the TERT promoter region.1 Publication

    GO - Molecular functioni

    1. ATP binding Source: InterPro
    2. DNA binding Source: UniProtKB-KW
    3. protein tyrosine kinase activity Source: UniProtKB

    GO - Biological processi

    1. peptidyl-tyrosine phosphorylation Source: GOC
    2. regulation of transcription, DNA-templated Source: UniProtKB-KW
    3. retrograde vesicle-mediated transport, Golgi to ER Source: UniProtKB
    4. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Activator

    Keywords - Biological processi

    ER-Golgi transport, Transcription, Transcription regulation, Transport

    Keywords - Ligandi

    DNA-binding

    Enzyme and pathway databases

    SignaLinkiQ96KG9.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    N-terminal kinase-like protein
    Alternative name(s):
    Coated vesicle-associated kinase of 90 kDa
    SCY1-like protein 1
    Telomerase regulation-associated protein
    Telomerase transcriptional element-interacting factor
    Teratoma-associated tyrosine kinase
    Gene namesi
    Name:SCYL1
    Synonyms:CVAK90, GKLP, NTKL, TAPK, TEIF, TRAP
    ORF Names:HT019
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:14372. SCYL1.

    Subcellular locationi

    Cytoplasmcytoskeletonmicrotubule organizing centercentrosome 1 Publication. Endoplasmic reticulum-Golgi intermediate compartment 1 Publication. Golgi apparatuscis-Golgi network 1 Publication
    Note: Localized to the Endoplasmic reticulum-Golgi intermediate and cis-Golgi in an ARF1-independent manner.
    Isoform 1 : Cytoplasm
    Note: Cytoplasmic throughout the cell cycle.
    Isoform 2 : Cytoplasm
    Note: Cytoplasmic throughout the cell cycle.
    Isoform 3 : Cytoplasm. Cytoplasmcytoskeletonmicrotubule organizing centercentrosome
    Note: Cytoplasmic during interphase and centrosomal during mitosis, it localizes to the centrosomes in a microtubule-independent manner.
    Isoform 6 : Nucleus 1 Publication

    GO - Cellular componenti

    1. cis-Golgi network Source: UniProtKB
    2. COPI vesicle coat Source: UniProtKB
    3. cytoplasm Source: HGNC
    4. endoplasmic reticulum-Golgi intermediate compartment Source: UniProtKB
    5. Golgi apparatus Source: UniProtKB
    6. membrane Source: UniProtKB
    7. microtubule organizing center Source: UniProtKB-SubCell
    8. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Cytoskeleton, Golgi apparatus, Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA31812.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 808808N-terminal kinase-like proteinPRO_0000249541Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei754 – 7541Phosphoserine2 Publications

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ96KG9.
    PaxDbiQ96KG9.
    PRIDEiQ96KG9.

    PTM databases

    PhosphoSiteiQ96KG9.

    Expressioni

    Tissue specificityi

    Ubiquitous.1 Publication

    Gene expression databases

    ArrayExpressiQ96KG9.
    BgeeiQ96KG9.
    CleanExiHS_SCYL1.
    GenevestigatoriQ96KG9.

    Organism-specific databases

    HPAiHPA015015.

    Interactioni

    Subunit structurei

    Interacts with GORAB. Interacts with COPA, COPB1 and COPB2 By similarity. Homooligomer. Interacts with AP2B1.By similarity2 Publications

    Protein-protein interaction databases

    BioGridi121512. 11 interactions.
    IntActiQ96KG9. 9 interactions.
    MINTiMINT-3055065.
    STRINGi9606.ENSP00000270176.

    Structurei

    3D structure databases

    ProteinModelPortaliQ96KG9.
    SMRiQ96KG9. Positions 29-526.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini14 – 314301Protein kinasePROSITE-ProRule annotationAdd
    BLAST
    Repeati350 – 38839HEAT 1Add
    BLAST
    Repeati389 – 42739HEAT 2Add
    BLAST
    Repeati507 – 54539HEAT 3Add
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni793 – 80816Interaction with COPB1By similarityAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili761 – 79737Sequence AnalysisAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi589 – 61931Pro-richAdd
    BLAST

    Domaini

    The protein kinase domain is predicted to be catalytically inactive.

    Sequence similaritiesi

    Belongs to the protein kinase superfamily.Curated
    Contains 3 HEAT repeats.Curated
    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil, Repeat

    Phylogenomic databases

    eggNOGiNOG293900.
    HOVERGENiHBG082065.
    InParanoidiQ96KG9.
    KOiK08876.
    OMAiQEDWSTG.
    OrthoDBiEOG7RJPQX.
    PhylomeDBiQ96KG9.
    TreeFamiTF313435.

    Family and domain databases

    Gene3Di1.25.10.10. 1 hit.
    InterProiIPR011989. ARM-like.
    IPR016024. ARM-type_fold.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    [Graphical view]
    PfamiPF00069. Pkinase. 1 hit.
    [Graphical view]
    SUPFAMiSSF48371. SSF48371. 1 hit.
    SSF56112. SSF56112. 1 hit.
    PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
    [Graphical view]

    Sequences (6)i

    Sequence statusi: Complete.

    This entry describes 6 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q96KG9-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MWFFARDPVR DFPFELIPEP PEGGLPGPWA LHRGRKKATG SPVSIFVYDV    50
    KPGAEEQTQV AKAAFKRFKT LRHPNILAYI DGLETEKCLH VVTEAVTPLG 100
    IYLKARVEAG GLKELEISWG LHQIVKALSF LVNDCSLIHN NVCMAAVFVD 150
    RAGEWKLGGL DYMYSAQGNG GGPPRKGIPE LEQYDPPELA DSSGRVVREK 200
    WSADMWRLGC LIWEVFNGPL PRAAALRNPG KIPKTLVPHY CELVGANPKV 250
    RPNPARFLQN CRAPGGFMSN RFVETNLFLE EIQIKEPAEK QKFFQELSKS 300
    LDAFPEDFCR HKVLPQLLTA FEFGNAGAVV LTPLFKVGKF LSAEEYQQKI 350
    IPVVVKMFSS TDRAMRIRLL QQMEQFIQYL DEPTVNTQIF PHVVHGFLDT 400
    NPAIREQTVK SMLLLAPKLN EANLNVELMK HFARLQAKDE QGPIRCNTTV 450
    CLGKIGSYLS ASTRHRVLTS AFSRATRDPF APSRVAGVLG FAATHNLYSM 500
    NDCAQKILPV LCGLTVDPEK SVRDQAFKAI RSFLSKLESV SEDPTQLEEV 550
    EKDVHAASSP GMGGAAASWA GWAVTGVSSL TSKLIRSHPT TAPTETNIPQ 600
    RPTPEGVPAP APTPVPATPT TSGHWETQEE DKDTAEDSST ADRWDDEDWG 650
    SLEQEAESVL AQQDDWSTGG QVSRASQVSN SDHKSSKSPE SDWSSWEAEG 700
    SWEQGWQEPS SQEPPPDGTR LASEYNWGGP ESSDKGDPFA TLSARPSTQP 750
    RPDSWGEDNW EGLETDSRQV KAELARKKRE ERRREMEAKR AERKVAKGPM 800
    KLGARKLD 808
    Length:808
    Mass (Da):89,631
    Last modified:December 1, 2001 - v1
    Checksum:iE87A2957DDCCE937
    GO
    Isoform 2 (identifier: Q96KG9-2) [UniParc]FASTAAdd to Basket

    Also known as: Variant 1

    The sequence of this isoform differs from the canonical sequence as follows:
         606-622: Missing.

    Show »
    Length:791
    Mass (Da):88,089
    Checksum:i79A8FA462666CBC5
    GO
    Isoform 3 (identifier: Q96KG9-3) [UniParc]FASTAAdd to Basket

    Also known as: Variant 2

    The sequence of this isoform differs from the canonical sequence as follows:
         606-622: Missing.
         628-711: Missing.

    Note: Non-canonical splice junctions.

    Show »
    Length:707
    Mass (Da):78,696
    Checksum:i2F2C81CD4EAF8225
    GO
    Isoform 4 (identifier: Q96KG9-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         750-808: PRPDSWGEDN...PMKLGARKLD → DRSRLSWPGRSARSGGGRWRPNAPRGRWPRAP

    Show »
    Length:781
    Mass (Da):86,312
    Checksum:i7DC90CF2578622FE
    GO
    Isoform 5 (identifier: Q96KG9-5) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         603-626: TPEGVPAPAPTPVPATPTTSGHWE → SRPARRPLGDAGGGQGHSRGQQHC
         627-808: Missing.

    Show »
    Length:626
    Mass (Da):69,238
    Checksum:i43E36C7298D8BB33
    GO
    Isoform 6 (identifier: Q96KG9-6) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         678-808: VSNSDHKSSK...PMKLGARKLD → SPTGAAGKLR...APRGRWPRAP

    Show »
    Length:787
    Mass (Da):86,371
    Checksum:iBD673D007B1A79B9
    GO

    Sequence cautioni

    The sequence AAG09726.1 differs from that shown. Reason: Frameshift at positions 289 and 307.
    The sequence AAG17902.1 differs from that shown. Reason: Frameshift at several positions.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti168 – 1692GN → AT in AAG17902. (PubMed:15504359)Curated
    Sequence conflicti530 – 5301I → F in AAG09726. 1 PublicationCurated
    Sequence conflicti574 – 5741V → W in AAG09726. 1 PublicationCurated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti479 – 4791P → L.1 Publication
    Corresponds to variant rs55977709 [ dbSNP | Ensembl ].
    VAR_041364
    Natural varianti495 – 4951H → Y in a metastatic melanoma sample; somatic mutation. 1 Publication
    VAR_041365
    Natural varianti663 – 6631Q → H.1 Publication
    Corresponds to variant rs56076708 [ dbSNP | Ensembl ].
    VAR_041366
    Natural varianti755 – 7551W → S.1 Publication
    Corresponds to variant rs56077405 [ dbSNP | Ensembl ].
    VAR_041367

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei603 – 62624TPEGV…SGHWE → SRPARRPLGDAGGGQGHSRG QQHC in isoform 5. 1 PublicationVSP_020503Add
    BLAST
    Alternative sequencei606 – 62217Missing in isoform 2 and isoform 3. 1 PublicationVSP_020504Add
    BLAST
    Alternative sequencei627 – 808182Missing in isoform 5. 1 PublicationVSP_020505Add
    BLAST
    Alternative sequencei628 – 71184Missing in isoform 3. 1 PublicationVSP_020506Add
    BLAST
    Alternative sequencei678 – 808131VSNSD…ARKLD → SPTGAAGKLRAPGNRAGRSQ APRSHLLTVHGWPASITGVA QSPATRATPSLPCLHVPAPS RGQTLGVRTTGRASRLTVDR SRLSWPGRSARSGGGRWRPN APRGRWPRAP in isoform 6. 1 PublicationVSP_020507Add
    BLAST
    Alternative sequencei750 – 80859PRPDS…ARKLD → DRSRLSWPGRSARSGGGRWR PNAPRGRWPRAP in isoform 4. 1 PublicationVSP_020508Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB047077 mRNA. Translation: BAB55454.1.
    AB051427 mRNA. Translation: BAB55458.1.
    AB051428 mRNA. Translation: BAB55459.1.
    AF297709 mRNA. Translation: AAG17902.1. Frameshift.
    AP000769 Genomic DNA. No translation available.
    CH471076 Genomic DNA. Translation: EAW74399.1.
    BC009967 mRNA. Translation: AAH09967.2.
    BC069233 mRNA. Translation: AAH69233.1.
    AF255613 Genomic DNA. Translation: AAF81422.1.
    AF225424 mRNA. Translation: AAG09726.1. Frameshift.
    CCDSiCCDS41672.1. [Q96KG9-1]
    CCDS44646.1. [Q96KG9-2]
    RefSeqiNP_001041683.1. NM_001048218.1. [Q96KG9-2]
    NP_065731.3. NM_020680.3. [Q96KG9-1]
    XP_005274177.1. XM_005274120.1. [Q96KG9-4]
    UniGeneiHs.238839.

    Genome annotation databases

    EnsembliENST00000270176; ENSP00000270176; ENSG00000142186. [Q96KG9-1]
    ENST00000279270; ENSP00000279270; ENSG00000142186. [Q96KG9-4]
    ENST00000420247; ENSP00000408192; ENSG00000142186. [Q96KG9-2]
    ENST00000533862; ENSP00000437254; ENSG00000142186. [Q96KG9-6]
    GeneIDi57410.
    KEGGihsa:57410.
    UCSCiuc001oea.1. human. [Q96KG9-1]
    uc001oeb.1. human. [Q96KG9-2]
    uc001oec.1. human. [Q96KG9-6]
    uc001oee.1. human. [Q96KG9-4]

    Polymorphism databases

    DMDMi74762671.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB047077 mRNA. Translation: BAB55454.1 .
    AB051427 mRNA. Translation: BAB55458.1 .
    AB051428 mRNA. Translation: BAB55459.1 .
    AF297709 mRNA. Translation: AAG17902.1 . Frameshift.
    AP000769 Genomic DNA. No translation available.
    CH471076 Genomic DNA. Translation: EAW74399.1 .
    BC009967 mRNA. Translation: AAH09967.2 .
    BC069233 mRNA. Translation: AAH69233.1 .
    AF255613 Genomic DNA. Translation: AAF81422.1 .
    AF225424 mRNA. Translation: AAG09726.1 . Frameshift.
    CCDSi CCDS41672.1. [Q96KG9-1 ]
    CCDS44646.1. [Q96KG9-2 ]
    RefSeqi NP_001041683.1. NM_001048218.1. [Q96KG9-2 ]
    NP_065731.3. NM_020680.3. [Q96KG9-1 ]
    XP_005274177.1. XM_005274120.1. [Q96KG9-4 ]
    UniGenei Hs.238839.

    3D structure databases

    ProteinModelPortali Q96KG9.
    SMRi Q96KG9. Positions 29-526.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 121512. 11 interactions.
    IntActi Q96KG9. 9 interactions.
    MINTi MINT-3055065.
    STRINGi 9606.ENSP00000270176.

    PTM databases

    PhosphoSitei Q96KG9.

    Polymorphism databases

    DMDMi 74762671.

    Proteomic databases

    MaxQBi Q96KG9.
    PaxDbi Q96KG9.
    PRIDEi Q96KG9.

    Protocols and materials databases

    DNASUi 57410.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000270176 ; ENSP00000270176 ; ENSG00000142186 . [Q96KG9-1 ]
    ENST00000279270 ; ENSP00000279270 ; ENSG00000142186 . [Q96KG9-4 ]
    ENST00000420247 ; ENSP00000408192 ; ENSG00000142186 . [Q96KG9-2 ]
    ENST00000533862 ; ENSP00000437254 ; ENSG00000142186 . [Q96KG9-6 ]
    GeneIDi 57410.
    KEGGi hsa:57410.
    UCSCi uc001oea.1. human. [Q96KG9-1 ]
    uc001oeb.1. human. [Q96KG9-2 ]
    uc001oec.1. human. [Q96KG9-6 ]
    uc001oee.1. human. [Q96KG9-4 ]

    Organism-specific databases

    CTDi 57410.
    GeneCardsi GC11P065292.
    HGNCi HGNC:14372. SCYL1.
    HPAi HPA015015.
    MIMi 607982. gene.
    neXtProti NX_Q96KG9.
    PharmGKBi PA31812.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG293900.
    HOVERGENi HBG082065.
    InParanoidi Q96KG9.
    KOi K08876.
    OMAi QEDWSTG.
    OrthoDBi EOG7RJPQX.
    PhylomeDBi Q96KG9.
    TreeFami TF313435.

    Enzyme and pathway databases

    SignaLinki Q96KG9.

    Miscellaneous databases

    ChiTaRSi SCYL1. human.
    GeneWikii SCYL1.
    GenomeRNAii 57410.
    NextBioi 63536.
    PROi Q96KG9.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q96KG9.
    Bgeei Q96KG9.
    CleanExi HS_SCYL1.
    Genevestigatori Q96KG9.

    Family and domain databases

    Gene3Di 1.25.10.10. 1 hit.
    InterProi IPR011989. ARM-like.
    IPR016024. ARM-type_fold.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    [Graphical view ]
    Pfami PF00069. Pkinase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48371. SSF48371. 1 hit.
    SSF56112. SSF56112. 1 hit.
    PROSITEi PS50011. PROTEIN_KINASE_DOM. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification and characterization of the human protein kinase-like gene NTKL: mitosis-specific centrosomal localization of an alternatively spliced isoform."
      Kato M., Yano K., Morotomi-Yano K., Saito H., Miki Y.
      Genomics 79:760-767(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3), SUBUNIT, TISSUE SPECIFICITY.
      Tissue: Testis.
    2. "Molecular cloning and characterization of a human gene involved in transcriptional regulation of hTERT."
      Tang Z., Zhao Y., Mei F., Yang S., Li X., Lv J., Hou L., Zhang B.
      Biochem. Biophys. Res. Commun. 324:1324-1332(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 6), DNA-BINDING (ISOFORM 6), SUBCELLULAR LOCATION (ISOFORM 6).
      Tissue: Cervix carcinoma.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 310-808 (ISOFORM 4).
      Tissue: Eye and Teratocarcinoma.
    6. "Construction of a 350-kb sequence-ready 11q13 cosmid contig encompassing the markers D11S4933 and D11S546: mapping of 11 genes and 3 tumor-associated translocation breakpoints."
      van Asseldonk M., Schepens M., de Bruijn D., Janssen B., Merkx G., Geurts van Kessel A.
      Genomics 66:35-42(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-283.
    7. Xiao H., Song H., Gao G., Ren S., Chen Z., Han Z.
      Submitted (JAN-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 288-808 (ISOFORM 5).
      Tissue: Hypothalamus.
    8. "Transcriptional upregulation of DNA polymerase beta by TEIF."
      Zhao Y., Zheng J., Ling Y., Hou L., Zhang B.
      Biochem. Biophys. Res. Commun. 333:908-916(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION (ISOFORM 6), DNA-BINDING (ISOFORM 6).
    9. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
      Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
      Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-754, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    10. "Role of the AP2 beta-appendage hub in recruiting partners for clathrin-coated vesicle assembly."
      Schmid E.M., Ford M.G.J., Burtey A., Praefcke G.J.K., Peak-Chew S.-Y., Mills I.G., Benmerah A., McMahon H.T.
      PLoS Biol. 4:E262-E262(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH AP2B1.
    11. "Scyl1, mutated in a recessive form of spinocerebellar neurodegeneration, regulates COPI-mediated retrograde traffic."
      Burman J.L., Bourbonniere L., Philie J., Stroh T., Dejgaard S.Y., Presley J.F., McPherson P.S.
      J. Biol. Chem. 283:22774-22786(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION.
    12. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-754, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    13. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    14. "Patterns of somatic mutation in human cancer genomes."
      Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G.
      , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.
      Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS [LARGE SCALE ANALYSIS] LEU-479; TYR-495; HIS-663 AND SER-755.

    Entry informationi

    Entry nameiNTKL_HUMAN
    AccessioniPrimary (citable) accession number: Q96KG9
    Secondary accession number(s): A6NJF1
    , Q96G50, Q96KG8, Q96KH1, Q9HAW5, Q9HBL3, Q9NR53
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 19, 2006
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 118 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3