Q96KG9 (NTKL_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
N-terminal kinase-like protein

Alternative name(s):
Coated vesicle-associated kinase of 90 kDa
SCY1-like protein 1
Telomerase regulation-associated protein
Telomerase transcriptional element-interacting factor
Teratoma-associated tyrosine kinase

Gene names

Name:	SCYL1
Synonyms:	CVAK90, GKLP, NTKL, TAPK, TEIF, TRAP
ORF Names:	HT019

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	808 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Regulates COPI-mediated retrograde traffic. Has no detectable kinase activity in vitro. Ref.8 Ref.11 Isoform 6 acts as transcriptional activator. It binds to three different types of GC-rich DNA binding sites (box-A, -B and -C) in the beta-polymerase promoter region. It also binds to the TERT promoter region. Ref.8 Ref.11
Subunit structure	Interacts with GORAB. Interacts with COPA, COPB1 and COPB2 By similarity. Homooligomer. Interacts with AP2B1. Ref.1 Ref.10
Subcellular location	Cytoplasm › cytoskeleton › centrosome. Endoplasmic reticulum-Golgi intermediate compartment. Golgi apparatus › cis-Golgi network. Note: Localized to the Endoplasmic reticulum-Golgi intermediate and cis-Golgi in an ARF1-independent manner. Ref.2 Ref.11 Isoform 1: Cytoplasm. Note: Cytoplasmic throughout the cell cycle. Ref.2 Ref.11 Isoform 2: Cytoplasm. Note: Cytoplasmic throughout the cell cycle. Ref.2 Ref.11 Isoform 3: Cytoplasm. Cytoplasm › cytoskeleton › centrosome. Note: Cytoplasmic during interphase and centrosomal during mitosis, it localizes to the centrosomes in a microtubule-independent manner. Ref.2 Ref.11 Isoform 6: Nucleus Ref.2 Ref.11.
Tissue specificity	Ubiquitous. Ref.1
Domain	The protein kinase domain is predicted to be catalytically inactive.
Sequence similarities	Belongs to the protein kinase superfamily. Contains 3 HEAT repeats. Contains 1 protein kinase domain.
Sequence caution	The sequence AAG09726.1 differs from that shown. Reason: Frameshift at positions 289 and 307. The sequence AAG17902.1 differs from that shown. Reason: Frameshift at several positions.

Ontologies

Keywords
Biological process	ER-Golgi transport Transcription Transcription regulation Transport
Cellular component	Cytoplasm Cytoskeleton Golgi apparatus Nucleus
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Coiled coil Repeat
Ligand	DNA-binding
Molecular function	Activator
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW retrograde vesicle-mediated transport, Golgi to ER Inferred from direct assay Ref.11. Source: UniProtKB transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	COPI vesicle coat Inferred from direct assay Ref.11. Source: UniProtKB cis-Golgi network Inferred from direct assay Ref.11. Source: UniProtKB endoplasmic reticulum-Golgi intermediate compartment Inferred from direct assay Ref.11. Source: UniProtKB microtubule organizing center Inferred from electronic annotation. Source: UniProtKB-SubCell nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: InterPro DNA binding Inferred from electronic annotation. Source: UniProtKB-KW protein tyrosine kinase activity Non-traceable author statement Ref.6. Source: UniProtKB
Complete GO annotation...

Alternative products

This entry describes 6 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q96KG9-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q96KG9-2)

Also known as: Variant 1;

The sequence of this isoform differs from the canonical sequence as follows:
     606-622: Missing.

Isoform 3 (identifier: Q96KG9-3)

Also known as: Variant 2;

The sequence of this isoform differs from the canonical sequence as follows:
     606-622: Missing.
     628-711: Missing.

Note: No experimental confirmation available.

Isoform 4 (identifier: Q96KG9-4)

The sequence of this isoform differs from the canonical sequence as follows:
     750-808: PRPDSWGEDN...PMKLGARKLD → DRSRLSWPGRSARSGGGRWRPNAPRGRWPRAP

Isoform 5 (identifier: Q96KG9-5)

The sequence of this isoform differs from the canonical sequence as follows:
     603-626: TPEGVPAPAPTPVPATPTTSGHWE → SRPARRPLGDAGGGQGHSRGQQHC
     627-808: Missing.

Isoform 6 (identifier: Q96KG9-6)

The sequence of this isoform differs from the canonical sequence as follows:
     678-808: VSNSDHKSSK...PMKLGARKLD → SPTGAAGKLR...APRGRWPRAP

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 808	808	N-terminal kinase-like protein		PRO_0000249541
Regions
	Domain	14 – 314	301	Protein kinase
	Repeat	350 – 388	39	HEAT 1
	Repeat	389 – 427	39	HEAT 2
	Repeat	507 – 545	39	HEAT 3
	Region	793 – 808	16	Interaction with COPB1 By similarity
	Coiled coil	761 – 797	37	Potential
	Compositional bias	589 – 619	31	Pro-rich
Amino acid modifications
	Modified residue	754	1	Phosphoserine Ref.9 Ref.12
Natural variations
	Alternative sequence	603 – 626	24	TPEGV…SGHWE → SRPARRPLGDAGGGQGHSRG QQHC in isoform 5.		VSP_020503
	Alternative sequence	606 – 622	17	Missing in isoform 2 and isoform 3.		VSP_020504
	Alternative sequence	627 – 808	182	Missing in isoform 5.		VSP_020505
	Alternative sequence	628 – 711	84	Missing in isoform 3.		VSP_020506
	Alternative sequence	678 – 808	131	VSNSD…ARKLD → SPTGAAGKLRAPGNRAGRSQ APRSHLLTVHGWPASITGVA QSPATRATPSLPCLHVPAPS RGQTLGVRTTGRASRLTVDR SRLSWPGRSARSGGGRWRPN APRGRWPRAP in isoform 6.		VSP_020507
	Alternative sequence	750 – 808	59	PRPDS…ARKLD → DRSRLSWPGRSARSGGGRWR PNAPRGRWPRAP in isoform 4.		VSP_020508
	Natural variant	479	1	P → L. Ref.14 Corresponds to variant rs55977709 [ dbSNP | Ensembl ].		VAR_041364
	Natural variant	495	1	H → Y in a metastatic melanoma sample; somatic mutation. Ref.14		VAR_041365
	Natural variant	663	1	Q → H. Ref.14 Corresponds to variant rs56076708 [ dbSNP | Ensembl ].		VAR_041366
	Natural variant	755	1	W → S. Ref.14 Corresponds to variant rs56077405 [ dbSNP | Ensembl ].		VAR_041367
Experimental info
	Sequence conflict	168 – 169	2	GN → AT in AAG17902. Ref.2
	Sequence conflict	530	1	I → F in AAG09726. Ref.7
	Sequence conflict	574	1	V → W in AAG09726. Ref.7

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: E87A2957DDCCE937	FASTA	808	89,631
	10 20 30 40 50 60 MWFFARDPVR DFPFELIPEP PEGGLPGPWA LHRGRKKATG SPVSIFVYDV KPGAEEQTQV 70 80 90 100 110 120 AKAAFKRFKT LRHPNILAYI DGLETEKCLH VVTEAVTPLG IYLKARVEAG GLKELEISWG 130 140 150 160 170 180 LHQIVKALSF LVNDCSLIHN NVCMAAVFVD RAGEWKLGGL DYMYSAQGNG GGPPRKGIPE 190 200 210 220 230 240 LEQYDPPELA DSSGRVVREK WSADMWRLGC LIWEVFNGPL PRAAALRNPG KIPKTLVPHY 250 260 270 280 290 300 CELVGANPKV RPNPARFLQN CRAPGGFMSN RFVETNLFLE EIQIKEPAEK QKFFQELSKS 310 320 330 340 350 360 LDAFPEDFCR HKVLPQLLTA FEFGNAGAVV LTPLFKVGKF LSAEEYQQKI IPVVVKMFSS 370 380 390 400 410 420 TDRAMRIRLL QQMEQFIQYL DEPTVNTQIF PHVVHGFLDT NPAIREQTVK SMLLLAPKLN 430 440 450 460 470 480 EANLNVELMK HFARLQAKDE QGPIRCNTTV CLGKIGSYLS ASTRHRVLTS AFSRATRDPF 490 500 510 520 530 540 APSRVAGVLG FAATHNLYSM NDCAQKILPV LCGLTVDPEK SVRDQAFKAI RSFLSKLESV 550 560 570 580 590 600 SEDPTQLEEV EKDVHAASSP GMGGAAASWA GWAVTGVSSL TSKLIRSHPT TAPTETNIPQ 610 620 630 640 650 660 RPTPEGVPAP APTPVPATPT TSGHWETQEE DKDTAEDSST ADRWDDEDWG SLEQEAESVL 670 680 690 700 710 720 AQQDDWSTGG QVSRASQVSN SDHKSSKSPE SDWSSWEAEG SWEQGWQEPS SQEPPPDGTR 730 740 750 760 770 780 LASEYNWGGP ESSDKGDPFA TLSARPSTQP RPDSWGEDNW EGLETDSRQV KAELARKKRE 790 800 ERRREMEAKR AERKVAKGPM KLGARKLD
	Isoform 2 (Variant 1) [UniParc]. Checksum: 79A8FA462666CBC5	FASTA	791	88,089
	10 20 30 40 50 60 MWFFARDPVR DFPFELIPEP PEGGLPGPWA LHRGRKKATG SPVSIFVYDV KPGAEEQTQV 70 80 90 100 110 120 AKAAFKRFKT LRHPNILAYI DGLETEKCLH VVTEAVTPLG IYLKARVEAG GLKELEISWG 130 140 150 160 170 180 LHQIVKALSF LVNDCSLIHN NVCMAAVFVD RAGEWKLGGL DYMYSAQGNG GGPPRKGIPE 190 200 210 220 230 240 LEQYDPPELA DSSGRVVREK WSADMWRLGC LIWEVFNGPL PRAAALRNPG KIPKTLVPHY 250 260 270 280 290 300 CELVGANPKV RPNPARFLQN CRAPGGFMSN RFVETNLFLE EIQIKEPAEK QKFFQELSKS 310 320 330 340 350 360 LDAFPEDFCR HKVLPQLLTA FEFGNAGAVV LTPLFKVGKF LSAEEYQQKI IPVVVKMFSS 370 380 390 400 410 420 TDRAMRIRLL QQMEQFIQYL DEPTVNTQIF PHVVHGFLDT NPAIREQTVK SMLLLAPKLN 430 440 450 460 470 480 EANLNVELMK HFARLQAKDE QGPIRCNTTV CLGKIGSYLS ASTRHRVLTS AFSRATRDPF 490 500 510 520 530 540 APSRVAGVLG FAATHNLYSM NDCAQKILPV LCGLTVDPEK SVRDQAFKAI RSFLSKLESV 550 560 570 580 590 600 SEDPTQLEEV EKDVHAASSP GMGGAAASWA GWAVTGVSSL TSKLIRSHPT TAPTETNIPQ 610 620 630 640 650 660 RPTPEGHWET QEEDKDTAED SSTADRWDDE DWGSLEQEAE SVLAQQDDWS TGGQVSRASQ 670 680 690 700 710 720 VSNSDHKSSK SPESDWSSWE AEGSWEQGWQ EPSSQEPPPD GTRLASEYNW GGPESSDKGD 730 740 750 760 770 780 PFATLSARPS TQPRPDSWGE DNWEGLETDS RQVKAELARK KREERRREME AKRAERKVAK 790 GPMKLGARKL D
	Isoform 3 (Variant 2) [UniParc]. Checksum: 2F2C81CD4EAF8225	FASTA	707	78,696
	10 20 30 40 50 60 MWFFARDPVR DFPFELIPEP PEGGLPGPWA LHRGRKKATG SPVSIFVYDV KPGAEEQTQV 70 80 90 100 110 120 AKAAFKRFKT LRHPNILAYI DGLETEKCLH VVTEAVTPLG IYLKARVEAG GLKELEISWG 130 140 150 160 170 180 LHQIVKALSF LVNDCSLIHN NVCMAAVFVD RAGEWKLGGL DYMYSAQGNG GGPPRKGIPE 190 200 210 220 230 240 LEQYDPPELA DSSGRVVREK WSADMWRLGC LIWEVFNGPL PRAAALRNPG KIPKTLVPHY 250 260 270 280 290 300 CELVGANPKV RPNPARFLQN CRAPGGFMSN RFVETNLFLE EIQIKEPAEK QKFFQELSKS 310 320 330 340 350 360 LDAFPEDFCR HKVLPQLLTA FEFGNAGAVV LTPLFKVGKF LSAEEYQQKI IPVVVKMFSS 370 380 390 400 410 420 TDRAMRIRLL QQMEQFIQYL DEPTVNTQIF PHVVHGFLDT NPAIREQTVK SMLLLAPKLN 430 440 450 460 470 480 EANLNVELMK HFARLQAKDE QGPIRCNTTV CLGKIGSYLS ASTRHRVLTS AFSRATRDPF 490 500 510 520 530 540 APSRVAGVLG FAATHNLYSM NDCAQKILPV LCGLTVDPEK SVRDQAFKAI RSFLSKLESV 550 560 570 580 590 600 SEDPTQLEEV EKDVHAASSP GMGGAAASWA GWAVTGVSSL TSKLIRSHPT TAPTETNIPQ 610 620 630 640 650 660 RPTPEGHWET QEPPPDGTRL ASEYNWGGPE SSDKGDPFAT LSARPSTQPR PDSWGEDNWE 670 680 690 700 GLETDSRQVK AELARKKREE RRREMEAKRA ERKVAKGPMK LGARKLD
	Isoform 4 [UniParc]. Checksum: 7DC90CF2578622FE	FASTA	781	86,312
	10 20 30 40 50 60 MWFFARDPVR DFPFELIPEP PEGGLPGPWA LHRGRKKATG SPVSIFVYDV KPGAEEQTQV 70 80 90 100 110 120 AKAAFKRFKT LRHPNILAYI DGLETEKCLH VVTEAVTPLG IYLKARVEAG GLKELEISWG 130 140 150 160 170 180 LHQIVKALSF LVNDCSLIHN NVCMAAVFVD RAGEWKLGGL DYMYSAQGNG GGPPRKGIPE 190 200 210 220 230 240 LEQYDPPELA DSSGRVVREK WSADMWRLGC LIWEVFNGPL PRAAALRNPG KIPKTLVPHY 250 260 270 280 290 300 CELVGANPKV RPNPARFLQN CRAPGGFMSN RFVETNLFLE EIQIKEPAEK QKFFQELSKS 310 320 330 340 350 360 LDAFPEDFCR HKVLPQLLTA FEFGNAGAVV LTPLFKVGKF LSAEEYQQKI IPVVVKMFSS 370 380 390 400 410 420 TDRAMRIRLL QQMEQFIQYL DEPTVNTQIF PHVVHGFLDT NPAIREQTVK SMLLLAPKLN 430 440 450 460 470 480 EANLNVELMK HFARLQAKDE QGPIRCNTTV CLGKIGSYLS ASTRHRVLTS AFSRATRDPF 490 500 510 520 530 540 APSRVAGVLG FAATHNLYSM NDCAQKILPV LCGLTVDPEK SVRDQAFKAI RSFLSKLESV 550 560 570 580 590 600 SEDPTQLEEV EKDVHAASSP GMGGAAASWA GWAVTGVSSL TSKLIRSHPT TAPTETNIPQ 610 620 630 640 650 660 RPTPEGVPAP APTPVPATPT TSGHWETQEE DKDTAEDSST ADRWDDEDWG SLEQEAESVL 670 680 690 700 710 720 AQQDDWSTGG QVSRASQVSN SDHKSSKSPE SDWSSWEAEG SWEQGWQEPS SQEPPPDGTR 730 740 750 760 770 780 LASEYNWGGP ESSDKGDPFA TLSARPSTQD RSRLSWPGRS ARSGGGRWRP NAPRGRWPRA P
	Isoform 5 [UniParc]. Checksum: 43E36C7298D8BB33	FASTA	626	69,238
	10 20 30 40 50 60 MWFFARDPVR DFPFELIPEP PEGGLPGPWA LHRGRKKATG SPVSIFVYDV KPGAEEQTQV 70 80 90 100 110 120 AKAAFKRFKT LRHPNILAYI DGLETEKCLH VVTEAVTPLG IYLKARVEAG GLKELEISWG 130 140 150 160 170 180 LHQIVKALSF LVNDCSLIHN NVCMAAVFVD RAGEWKLGGL DYMYSAQGNG GGPPRKGIPE 190 200 210 220 230 240 LEQYDPPELA DSSGRVVREK WSADMWRLGC LIWEVFNGPL PRAAALRNPG KIPKTLVPHY 250 260 270 280 290 300 CELVGANPKV RPNPARFLQN CRAPGGFMSN RFVETNLFLE EIQIKEPAEK QKFFQELSKS 310 320 330 340 350 360 LDAFPEDFCR HKVLPQLLTA FEFGNAGAVV LTPLFKVGKF LSAEEYQQKI IPVVVKMFSS 370 380 390 400 410 420 TDRAMRIRLL QQMEQFIQYL DEPTVNTQIF PHVVHGFLDT NPAIREQTVK SMLLLAPKLN 430 440 450 460 470 480 EANLNVELMK HFARLQAKDE QGPIRCNTTV CLGKIGSYLS ASTRHRVLTS AFSRATRDPF 490 500 510 520 530 540 APSRVAGVLG FAATHNLYSM NDCAQKILPV LCGLTVDPEK SVRDQAFKAI RSFLSKLESV 550 560 570 580 590 600 SEDPTQLEEV EKDVHAASSP GMGGAAASWA GWAVTGVSSL TSKLIRSHPT TAPTETNIPQ 610 620 RPSRPARRPL GDAGGGQGHS RGQQHC
	Isoform 6 [UniParc]. Checksum: BD673D007B1A79B9	FASTA	787	86,371
	10 20 30 40 50 60 MWFFARDPVR DFPFELIPEP PEGGLPGPWA LHRGRKKATG SPVSIFVYDV KPGAEEQTQV 70 80 90 100 110 120 AKAAFKRFKT LRHPNILAYI DGLETEKCLH VVTEAVTPLG IYLKARVEAG GLKELEISWG 130 140 150 160 170 180 LHQIVKALSF LVNDCSLIHN NVCMAAVFVD RAGEWKLGGL DYMYSAQGNG GGPPRKGIPE 190 200 210 220 230 240 LEQYDPPELA DSSGRVVREK WSADMWRLGC LIWEVFNGPL PRAAALRNPG KIPKTLVPHY 250 260 270 280 290 300 CELVGANPKV RPNPARFLQN CRAPGGFMSN RFVETNLFLE EIQIKEPAEK QKFFQELSKS 310 320 330 340 350 360 LDAFPEDFCR HKVLPQLLTA FEFGNAGAVV LTPLFKVGKF LSAEEYQQKI IPVVVKMFSS 370 380 390 400 410 420 TDRAMRIRLL QQMEQFIQYL DEPTVNTQIF PHVVHGFLDT NPAIREQTVK SMLLLAPKLN 430 440 450 460 470 480 EANLNVELMK HFARLQAKDE QGPIRCNTTV CLGKIGSYLS ASTRHRVLTS AFSRATRDPF 490 500 510 520 530 540 APSRVAGVLG FAATHNLYSM NDCAQKILPV LCGLTVDPEK SVRDQAFKAI RSFLSKLESV 550 560 570 580 590 600 SEDPTQLEEV EKDVHAASSP GMGGAAASWA GWAVTGVSSL TSKLIRSHPT TAPTETNIPQ 610 620 630 640 650 660 RPTPEGVPAP APTPVPATPT TSGHWETQEE DKDTAEDSST ADRWDDEDWG SLEQEAESVL 670 680 690 700 710 720 AQQDDWSTGG QVSRASQSPT GAAGKLRAPG NRAGRSQAPR SHLLTVHGWP ASITGVAQSP 730 740 750 760 770 780 ATRATPSLPC LHVPAPSRGQ TLGVRTTGRA SRLTVDRSRL SWPGRSARSG GGRWRPNAPR GRWPRAP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification and characterization of the human protein kinase-like gene NTKL: mitosis-specific centrosomal localization of an alternatively spliced isoform." Kato M., Yano K., Morotomi-Yano K., Saito H., Miki Y. Genomics 79:760-767(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3), SUBUNIT, TISSUE SPECIFICITY. Tissue: Testis.
[2]	"Molecular cloning and characterization of a human gene involved in transcriptional regulation of hTERT." Tang Z., Zhao Y., Mei F., Yang S., Li X., Lv J., Hou L., Zhang B. Biochem. Biophys. Res. Commun. 324:1324-1332(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 6), DNA-BINDING (ISOFORM 6), SUBCELLULAR LOCATION (ISOFORM 6). Tissue: Cervix carcinoma.
[3]	"Human chromosome 11 DNA sequence and analysis including novel gene identification." Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G. , Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S., Sakaki Y. Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 310-808 (ISOFORM 4). Tissue: Eye and Teratocarcinoma.
[6]	"Construction of a 350-kb sequence-ready 11q13 cosmid contig encompassing the markers D11S4933 and D11S546: mapping of 11 genes and 3 tumor-associated translocation breakpoints." van Asseldonk M., Schepens M., de Bruijn D., Janssen B., Merkx G., Geurts van Kessel A. Genomics 66:35-42(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-283.
[7]	Xiao H., Song H., Gao G., Ren S., Chen Z., Han Z. Submitted (JAN-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 288-808 (ISOFORM 5). Tissue: Hypothalamus.
[8]	"Transcriptional upregulation of DNA polymerase beta by TEIF." Zhao Y., Zheng J., Ling Y., Hou L., Zhang B. Biochem. Biophys. Res. Commun. 333:908-916(2005) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION (ISOFORM 6), DNA-BINDING (ISOFORM 6).
[9]	"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-754, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[10]	"Role of the AP2 beta-appendage hub in recruiting partners for clathrin-coated vesicle assembly." Schmid E.M., Ford M.G.J., Burtey A., Praefcke G.J.K., Peak-Chew S.-Y., Mills I.G., Benmerah A., McMahon H.T. PLoS Biol. 4:E262-E262(2006) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH AP2B1.
[11]	"Scyl1, mutated in a recessive form of spinocerebellar neurodegeneration, regulates COPI-mediated retrograde traffic." Burman J.L., Bourbonniere L., Philie J., Stroh T., Dejgaard S.Y., Presley J.F., McPherson P.S. J. Biol. Chem. 283:22774-22786(2008) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, SUBCELLULAR LOCATION.
[12]	"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis." Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M. Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-754, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[13]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[14]	"Patterns of somatic mutation in human cancer genomes." Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G. , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R. Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANTS [LARGE SCALE ANALYSIS] LEU-479; TYR-495; HIS-663 AND SER-755.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB047077 mRNA. Translation: BAB55454.1. AB051427 mRNA. Translation: BAB55458.1. AB051428 mRNA. Translation: BAB55459.1. AF297709 mRNA. Translation: AAG17902.1. Frameshift. AP000769 Genomic DNA. No translation available. CH471076 Genomic DNA. Translation: EAW74399.1. BC009967 mRNA. Translation: AAH09967.2. BC069233 mRNA. Translation: AAH69233.1. AF255613 Genomic DNA. Translation: AAF81422.1. AF225424 mRNA. Translation: AAG09726.1. Frameshift.
IPI	IPI00062264. IPI00102059. IPI00186969. IPI00787009. IPI00788043. IPI00788089.
RefSeq	NP_001041683.1. NM_001048218.1. NP_065731.3. NM_020680.3.
UniGene	Hs.238839.
3D structure databases
ProteinModelPortal	Q96KG9.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q96KG9. 9 interactions.
MINT	MINT-3055065.
STRING	9606.ENSP00000270176.
PTM databases
PhosphoSite	Q96KG9.
Polymorphism databases
DMDM	74762671.
Proteomic databases
PaxDb	Q96KG9.
PRIDE	Q96KG9.
Protocols and materials databases
DNASU	57410.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000270176; ENSP00000270176; ENSG00000142186. ENST00000279270; ENSP00000279270; ENSG00000142186. ENST00000420247; ENSP00000408192; ENSG00000142186. ENST00000527630; ENSP00000433450; ENSG00000142186. ENST00000533862; ENSP00000437254; ENSG00000142186.
GeneID	57410.
KEGG	hsa:57410.
UCSC	uc001oea.1. human. uc001oeb.1. human. uc001oec.1. human. uc001oee.1. human.
Organism-specific databases
CTD	57410.
GeneCards	GC11P065292.
HGNC	HGNC:14372. SCYL1.
HPA	HPA015015.
MIM	607982. gene.
neXtProt	NX_Q96KG9.
PharmGKB	PA31812.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG293900.
HOVERGEN	HBG082065.
InParanoid	Q96KG9.
KO	K08876.
OMA	LGIYLKA.
OrthoDB	EOG40CHGC.
PhylomeDB	Q96KG9.
Enzyme and pathway databases
SignaLink	Q96KG9.
Gene expression databases
ArrayExpress	Q96KG9.
Bgee	Q96KG9.
CleanEx	HS_SCYL1.
Genevestigator	Q96KG9.
GermOnline	ENSG00000142186. Homo sapiens.
Family and domain databases
Gene3D	1.25.10.10. 1 hit.
InterPro	IPR011989. ARM-like. IPR016024. ARM-type_fold. IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_cat_dom. [Graphical view]
Pfam	PF00069. Pkinase. 1 hit. [Graphical view]
SUPFAM	SSF48371. ARM-type_fold. 1 hit. SSF56112. Kinase_like. 1 hit.
PROSITE	PS50077. HEAT_REPEAT. False negative. PS50011. PROTEIN_KINASE_DOM. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	SCYL1. human.
GenomeRNAi	57410.
NextBio	63536.
SOURCE	Search...

Entry information

Entry name

NTKL_HUMAN

Accession

Primary (citable) accession number: Q96KG9
Secondary accession number(s): A6NJF1 , Q96G50, Q96KG8, Q96KH1, Q9HAW5, Q9HBL3, Q9NR53

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 19, 2006
Last sequence update:	December 1, 2001
Last modified:	May 29, 2013
This is version 107 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.