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Q96KG7

- MEG10_HUMAN

UniProt

Q96KG7 - MEG10_HUMAN

Protein

Multiple epidermal growth factor-like domains protein 10

Gene

MEGF10

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 102 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    Membrane receptor involved in phagocytosis by macrophages of apoptotic cells. Cooperates with ABCA1 within the process of engulfment. Promotes the formation of large intracellular vacuoles and may be responsible for the uptake of amyloid-beta peptides. May also function in the mosaic spacing of specific neuron subtypes in the retina through homotypic retinal neuron repulsion. Mosaics provide a mechanism to distribute each cell type evenly across the retina, ensuring that all parts of the visual field have access to a full set of processing elements. May play role in cell adhesion and motility. Is also an essential factor in the regulation of myogenesis. Controls the balance between skeletal muscle satellite cells proliferation and differentiation problably through regulation of the notch signaling pathway.4 Publications

    GO - Biological processi

    1. homotypic cell-cell adhesion Source: UniProtKB
    2. muscle cell development Source: UniProtKB
    3. recognition of apoptotic cell Source: Ensembl
    4. regulation of muscle cell differentiation Source: UniProtKB
    5. regulation of skeletal muscle tissue development Source: UniProtKB
    6. skeletal muscle satellite cell activation Source: UniProtKB
    7. skeletal muscle satellite cell differentiation Source: UniProtKB
    8. skeletal muscle satellite cell proliferation Source: UniProtKB

    Keywords - Biological processi

    Cell adhesion, Myogenesis, Phagocytosis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Multiple epidermal growth factor-like domains protein 10
    Short name:
    Multiple EGF-like domains protein 10
    Gene namesi
    Name:MEGF10
    Synonyms:KIAA1780
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 5

    Organism-specific databases

    HGNCiHGNC:29634. MEGF10.

    Subcellular locationi

    Cell membrane; Single-pass type I membrane protein. Basolateral cell membrane; Single-pass type I membrane protein. Cell projectionphagocytic cup
    Note: Enriched at the sites of contact with apoptotic thymocyte cells By similarity. Forms an irregular, mosaic-like adhesion pattern in region of the cell surface that becomes firmely fixed to the substrate. Expressed at the cell surface in clusters around cell corpses during engulfment. During the engulfment of apoptotic thymocytes, recruited at the bottom of the forming phagocytic cup. Colocalizes with ABCA1 in absence of any phagocytic challenge. Does not localize within lamellipodia. Does not localize with MEGF11.By similarity

    GO - Cellular componenti

    1. basolateral plasma membrane Source: UniProtKB-SubCell
    2. cell projection Source: UniProtKB-KW
    3. integral component of membrane Source: UniProtKB-KW
    4. phagocytic cup Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Cell projection, Membrane

    Pathology & Biotechi

    Involvement in diseasei

    Myopathy, early-onset, areflexia, respiratory distress, and dysphagia (EMARDD) [MIM:614399]: An autosomal recessive congenital myopathy characterized by onset at birth, or early in infancy, of respiratory distress caused by diaphragmatic weakness. Additional features are dysphagia resulting in poor feeding, failure to thrive, poor head control, facial weakness, cleft palate, contractures and scoliosis. Affected individuals become ventilator-dependent, and most require feeding by gastrostomy. The disorder results in severe muscle weakness and most patients never achieve walking. Death from respiratory failure in childhood occurs in about half of patients. Muscle biopsies from affected individuals show myopathic changes, replacement of myofibers with fatty tissue, small and incompletely fused muscle fibers, and variation in fiber size. Short regions of sarcomeric disorganization with few or no mitochondria (minicores) have been observed in some cases.2 Publications
    Note: The disease is caused by mutations affecting the gene represented in this entry.
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti71 – 711R → W in a patient with EMARDD; unknown pathological significance. 1 Publication
    VAR_067469
    Natural varianti326 – 3261C → R in EMARDD. 1 Publication
    VAR_067470
    Natural varianti774 – 7741C → R in EMARDD. 2 Publications
    VAR_067471

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi927 – 9271N → A: Does not interact with GULP1; when associated with A-930. 1 Publication
    Mutagenesisi930 – 9301Y → A: Does not interact with GULP1; when associated with A-927. 1 Publication

    Keywords - Diseasei

    Disease mutation

    Organism-specific databases

    MIMi614399. phenotype.
    Orphaneti98920. Spinal muscular atrophy with respiratory distress.
    PharmGKBiPA144596410.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2525Sequence AnalysisAdd
    BLAST
    Chaini26 – 11401115Multiple epidermal growth factor-like domains protein 10PRO_0000309732Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi34 ↔ 95Sequence Analysis
    Disulfide bondi60 ↔ 69Sequence Analysis
    Disulfide bondi94 ↔ 105Sequence Analysis
    Disulfide bondi109 ↔ 118By similarity
    Disulfide bondi113 ↔ 124By similarity
    Disulfide bondi126 ↔ 135By similarity
    Glycosylationi134 – 1341N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi148 ↔ 160By similarity
    Disulfide bondi154 ↔ 167By similarity
    Disulfide bondi169 ↔ 178By similarity
    Disulfide bondi191 ↔ 203By similarity
    Disulfide bondi197 ↔ 210By similarity
    Disulfide bondi212 ↔ 221By similarity
    Disulfide bondi234 ↔ 246By similarity
    Disulfide bondi240 ↔ 253By similarity
    Disulfide bondi255 ↔ 264By similarity
    Disulfide bondi281 ↔ 289By similarity
    Disulfide bondi283 ↔ 296By similarity
    Disulfide bondi298 ↔ 307By similarity
    Disulfide bondi320 ↔ 332By similarity
    Disulfide bondi326 ↔ 339By similarity
    Disulfide bondi341 ↔ 350By similarity
    Disulfide bondi409 ↔ 421By similarity
    Disulfide bondi415 ↔ 428By similarity
    Disulfide bondi430 ↔ 439By similarity
    Disulfide bondi456 ↔ 464By similarity
    Disulfide bondi458 ↔ 471By similarity
    Disulfide bondi473 ↔ 482By similarity
    Disulfide bondi495 ↔ 507By similarity
    Glycosylationi496 – 4961N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi501 ↔ 514By similarity
    Disulfide bondi516 ↔ 525By similarity
    Disulfide bondi542 ↔ 550By similarity
    Disulfide bondi544 ↔ 557By similarity
    Disulfide bondi559 ↔ 568By similarity
    Disulfide bondi581 ↔ 593By similarity
    Disulfide bondi587 ↔ 600By similarity
    Disulfide bondi602 ↔ 611By similarity
    Disulfide bondi669 ↔ 681By similarity
    Disulfide bondi675 ↔ 688By similarity
    Disulfide bondi690 ↔ 699By similarity
    Disulfide bondi716 ↔ 724By similarity
    Disulfide bondi718 ↔ 731By similarity
    Disulfide bondi733 ↔ 742By similarity
    Disulfide bondi755 ↔ 767By similarity
    Disulfide bondi761 ↔ 774By similarity
    Disulfide bondi776 ↔ 785By similarity
    Disulfide bondi802 ↔ 810By similarity
    Disulfide bondi804 ↔ 817By similarity
    Disulfide bondi819 ↔ 828By similarity

    Post-translational modificationi

    Phosphorylated on tyrosine residues.1 Publication
    Ubiquitinated; mono- and polyubiquitinated forms are detected.1 Publication

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Ubl conjugation

    Proteomic databases

    PaxDbiQ96KG7.
    PRIDEiQ96KG7.

    PTM databases

    PhosphoSiteiQ96KG7.

    Expressioni

    Gene expression databases

    BgeeiQ96KG7.
    CleanExiHS_MEGF10.
    GenevestigatoriQ96KG7.

    Organism-specific databases

    HPAiHPA026876.

    Interactioni

    Subunit structurei

    Homopolymer Probable. Interacts with GULP1 and ABCA1. Interacts with AP2M1. Does not interact with MEGF11.3 PublicationsCurated

    Protein-protein interaction databases

    BioGridi124099. 5 interactions.
    IntActiQ96KG7. 24 interactions.
    STRINGi9606.ENSP00000274473.

    Structurei

    3D structure databases

    ProteinModelPortaliQ96KG7.
    SMRiQ96KG7. Positions 85-833.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini26 – 857832ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini879 – 1140262CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei858 – 87821HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini30 – 10778EMIPROSITE-ProRule annotationAdd
    BLAST
    Domaini106 – 13631EGF-like 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini144 – 17936EGF-like 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini187 – 22236EGF-like 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini230 – 26536EGF-like 4PROSITE-ProRule annotationAdd
    BLAST
    Domaini278 – 30831EGF-like 5PROSITE-ProRule annotationAdd
    BLAST
    Domaini316 – 35136EGF-like 6PROSITE-ProRule annotationAdd
    BLAST
    Domaini405 – 44036EGF-like 7PROSITE-ProRule annotationAdd
    BLAST
    Domaini453 – 48331EGF-like 8PROSITE-ProRule annotationAdd
    BLAST
    Domaini491 – 52636EGF-like 9PROSITE-ProRule annotationAdd
    BLAST
    Domaini539 – 56931EGF-like 10PROSITE-ProRule annotationAdd
    BLAST
    Domaini577 – 61236EGF-like 11PROSITE-ProRule annotationAdd
    BLAST
    Domaini665 – 70036EGF-like 12PROSITE-ProRule annotationAdd
    BLAST
    Domaini713 – 74331EGF-like 13PROSITE-ProRule annotationAdd
    BLAST
    Domaini751 – 78636EGF-like 14PROSITE-ProRule annotationAdd
    BLAST
    Domaini799 – 82931EGF-like 15PROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 857857Necessary for interaction with AP2M1, self-assembly and formation of the irregular, mosaic-like adhesion patternAdd
    BLAST
    Regioni945 – 1140196Necessary for formation of large intracellular vacuolesAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi1119 – 113921Ser-richAdd
    BLAST

    Domaini

    The EMI and EGF-like domains work in concert to promote self-assembly.

    Sequence similaritiesi

    Belongs to the MEGF family.Curated
    Contains 15 EGF-like domains.PROSITE-ProRule annotation
    Contains 1 EMI domain.PROSITE-ProRule annotation

    Keywords - Domaini

    EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG12793.
    HOGENOMiHOG000294130.
    HOVERGENiHBG108333.
    InParanoidiQ96KG7.
    OMAiFGCNLTC.
    OrthoDBiEOG72C50D.
    PhylomeDBiQ96KG7.
    TreeFamiTF332598.

    Family and domain databases

    InterProiIPR000742. EG-like_dom.
    IPR013032. EGF-like_CS.
    IPR002049. EGF_laminin.
    IPR011489. EMI_domain.
    [Graphical view]
    PfamiPF12661. hEGF. 3 hits.
    PF00053. Laminin_EGF. 4 hits.
    [Graphical view]
    SMARTiSM00181. EGF. 11 hits.
    SM00180. EGF_Lam. 6 hits.
    [Graphical view]
    PROSITEiPS00022. EGF_1. 17 hits.
    PS01186. EGF_2. 17 hits.
    PS50026. EGF_3. 15 hits.
    PS51041. EMI. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q96KG7-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MVISLNSCLS FICLLLCHWI GTASPLNLED PNVCSHWESY SVTVQESYPH     50
    PFDQIYYTSC TDILNWFKCT RHRVSYRTAY RHGEKTMYRR KSQCCPGFYE 100
    SGEMCVPHCA DKCVHGRCIA PNTCQCEPGW GGTNCSSACD GDHWGPHCTS 150
    RCQCKNGALC NPITGACHCA AGFRGWRCED RCEQGTYGND CHQRCQCQNG 200
    ATCDHVTGEC RCPPGYTGAF CEDLCPPGKH GPQCEQRCPC QNGGVCHHVT 250
    GECSCPSGWM GTVCGQPCPE GRFGKNCSQE CQCHNGGTCD AATGQCHCSP 300
    GYTGERCQDE CPVGTYGVLC AETCQCVNGG KCYHVSGACL CEAGFAGERC 350
    EARLCPEGLY GIKCDKRCPC HLENTHSCHP MSGECACKPG WSGLYCNETC 400
    SPGFYGEACQ QICSCQNGAD CDSVTGKCTC APGFKGIDCS TPCPLGTYGI 450
    NCSSRCGCKN DAVCSPVDGS CTCKAGWHGV DCSIRCPSGT WGFGCNLTCQ 500
    CLNGGACNTL DGTCTCAPGW RGEKCELPCQ DGTYGLNCAE RCDCSHADGC 550
    HPTTGHCRCL PGWSGVHCDS VCAEGRWGPN CSLPCYCKNG ASCSPDDGIC 600
    ECAPGFRGTT CQRICSPGFY GHRCSQTCPQ CVHSSGPCHH ITGLCDCLPG 650
    FTGALCNEVC PSGRFGKNCA GICTCTNNGT CNPIDRSCQC YPGWIGSDCS 700
    QPCPPAHWGP NCIHTCNCHN GAFCSAYDGE CKCTPGWTGL YCTQRCPLGF 750
    YGKDCALICQ CQNGADCDHI SGQCTCRTGF MGRHCEQKCP SGTYGYGCRQ 800
    ICDCLNNSTC DHITGTCYCS PGWKGARCDQ AGVIIVGNLN SLSRTSTALP 850
    ADSYQIGAIA GIIILVLVVL FLLALFIIYR HKQKGKESSM PAVTYTPAMR 900
    VVNADYTISG TLPHSNGGNA NSHYFTNPSY HTLTQCATSP HVNNRDRMTV 950
    TKSKNNQLFV NLKNVNPGKR GPVGDCTGTL PADWKHGGYL NELGAFGLDR 1000
    SYMGKSLKDL GKNSEYNSSN CSLSSSENPY ATIKDPPVLI PKSSECGYVE 1050
    MKSPARRDSP YAEINNSTSA NRNVYEVEPT VSVVQGVFSN NGRLSQDPYD 1100
    LPKNSHIPCH YDLLPVRDSS SSPKQEDSGG SSSNSSSSSE 1140
    Length:1,140
    Mass (Da):122,205
    Last modified:December 1, 2001 - v1
    Checksum:i45B2FA239423895A
    GO
    Isoform 2 (identifier: Q96KG7-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         566-567: VH → LF
         568-1140: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:567
    Mass (Da):60,797
    Checksum:iCF2FB8CDEB7CF627
    GO

    Sequence cautioni

    The sequence BAB47409.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti543 – 5431D → G in CAH18275. (PubMed:17974005)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti71 – 711R → W in a patient with EMARDD; unknown pathological significance. 1 Publication
    VAR_067469
    Natural varianti206 – 2061V → I.
    Corresponds to variant rs3812054 [ dbSNP | Ensembl ].
    VAR_036988
    Natural varianti326 – 3261C → R in EMARDD. 1 Publication
    VAR_067470
    Natural varianti774 – 7741C → R in EMARDD. 2 Publications
    VAR_067471
    Natural varianti897 – 8971P → L.
    Corresponds to variant rs13183625 [ dbSNP | Ensembl ].
    VAR_046377
    Natural varianti1072 – 10721R → K.
    Corresponds to variant rs17164935 [ dbSNP | Ensembl ].
    VAR_036989

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei566 – 5672VH → LF in isoform 2. 1 PublicationVSP_029244
    Alternative sequencei568 – 1140573Missing in isoform 2. 1 PublicationVSP_029245Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB058676 mRNA. Translation: BAB47409.2. Different initiation.
    CR749437 mRNA. Translation: CAH18275.1.
    CH471062 Genomic DNA. Translation: EAW62406.1.
    BC020198 mRNA. Translation: AAH20198.1.
    BC152478 mRNA. Translation: AAI52479.1.
    CCDSiCCDS4142.1. [Q96KG7-1]
    RefSeqiNP_001243474.1. NM_001256545.1. [Q96KG7-1]
    NP_115822.1. NM_032446.2. [Q96KG7-1]
    UniGeneiHs.438709.

    Genome annotation databases

    EnsembliENST00000274473; ENSP00000274473; ENSG00000145794. [Q96KG7-1]
    ENST00000418761; ENSP00000416284; ENSG00000145794. [Q96KG7-2]
    ENST00000503335; ENSP00000423354; ENSG00000145794. [Q96KG7-1]
    ENST00000508365; ENSP00000423195; ENSG00000145794. [Q96KG7-2]
    GeneIDi84466.
    KEGGihsa:84466.
    UCSCiuc003kuh.4. human. [Q96KG7-1]
    uc010jdc.1. human. [Q96KG7-2]

    Polymorphism databases

    DMDMi74716908.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB058676 mRNA. Translation: BAB47409.2 . Different initiation.
    CR749437 mRNA. Translation: CAH18275.1 .
    CH471062 Genomic DNA. Translation: EAW62406.1 .
    BC020198 mRNA. Translation: AAH20198.1 .
    BC152478 mRNA. Translation: AAI52479.1 .
    CCDSi CCDS4142.1. [Q96KG7-1 ]
    RefSeqi NP_001243474.1. NM_001256545.1. [Q96KG7-1 ]
    NP_115822.1. NM_032446.2. [Q96KG7-1 ]
    UniGenei Hs.438709.

    3D structure databases

    ProteinModelPortali Q96KG7.
    SMRi Q96KG7. Positions 85-833.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 124099. 5 interactions.
    IntActi Q96KG7. 24 interactions.
    STRINGi 9606.ENSP00000274473.

    PTM databases

    PhosphoSitei Q96KG7.

    Polymorphism databases

    DMDMi 74716908.

    Proteomic databases

    PaxDbi Q96KG7.
    PRIDEi Q96KG7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000274473 ; ENSP00000274473 ; ENSG00000145794 . [Q96KG7-1 ]
    ENST00000418761 ; ENSP00000416284 ; ENSG00000145794 . [Q96KG7-2 ]
    ENST00000503335 ; ENSP00000423354 ; ENSG00000145794 . [Q96KG7-1 ]
    ENST00000508365 ; ENSP00000423195 ; ENSG00000145794 . [Q96KG7-2 ]
    GeneIDi 84466.
    KEGGi hsa:84466.
    UCSCi uc003kuh.4. human. [Q96KG7-1 ]
    uc010jdc.1. human. [Q96KG7-2 ]

    Organism-specific databases

    CTDi 84466.
    GeneCardsi GC05P126654.
    HGNCi HGNC:29634. MEGF10.
    HPAi HPA026876.
    MIMi 612453. gene.
    614399. phenotype.
    neXtProti NX_Q96KG7.
    Orphaneti 98920. Spinal muscular atrophy with respiratory distress.
    PharmGKBi PA144596410.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG12793.
    HOGENOMi HOG000294130.
    HOVERGENi HBG108333.
    InParanoidi Q96KG7.
    OMAi FGCNLTC.
    OrthoDBi EOG72C50D.
    PhylomeDBi Q96KG7.
    TreeFami TF332598.

    Miscellaneous databases

    GeneWikii MEGF10.
    GenomeRNAii 84466.
    NextBioi 74274.
    PROi Q96KG7.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q96KG7.
    CleanExi HS_MEGF10.
    Genevestigatori Q96KG7.

    Family and domain databases

    InterProi IPR000742. EG-like_dom.
    IPR013032. EGF-like_CS.
    IPR002049. EGF_laminin.
    IPR011489. EMI_domain.
    [Graphical view ]
    Pfami PF12661. hEGF. 3 hits.
    PF00053. Laminin_EGF. 4 hits.
    [Graphical view ]
    SMARTi SM00181. EGF. 11 hits.
    SM00180. EGF_Lam. 6 hits.
    [Graphical view ]
    PROSITEi PS00022. EGF_1. 17 hits.
    PS01186. EGF_2. 17 hits.
    PS50026. EGF_3. 15 hits.
    PS51041. EMI. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
      Nagase T., Nakayama M., Nakajima D., Kikuno R., Ohara O.
      DNA Res. 8:85-95(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Retina.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Muscle.
    5. "Cooperation between engulfment receptors: the case of ABCA1 and MEGF10."
      Hamon Y., Trompier D., Ma Z., Venegas V., Pophillat M., Mignotte V., Zhou Z., Chimini G.
      PLoS ONE 1:E120-E120(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH GULP1 AND ABCA1, MUTAGENESIS OF ASN-927 AND TYR-930, SUBCELLULAR LOCATION.
    6. "The mammalian Ced-1 ortholog MEGF10/KIAA1780 displays a novel adhesion pattern."
      Suzuki E., Nakayama M.
      Exp. Cell Res. 313:2451-2464(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBUNIT, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    7. "MEGF10 is a mammalian ortholog of CED-1 that interacts with clathrin assembly protein complex 2 medium chain and induces large vacuole formation."
      Suzuki E., Nakayama M.
      Exp. Cell Res. 313:3729-3742(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, IDENTIFICATION BY MASS SPECTROMETRY, INTERACTION WITH AP2M1 AND GULP1, PHOSPHORYLATION, UBIQUITINATION.
    8. "MEGF10 functions as a receptor for the uptake of amyloid-beta."
      Singh T.D., Park S.Y., Bae J.S., Yun Y., Bae Y.C., Park R.W., Kim I.S.
      FEBS Lett. 584:3936-3942(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION IN ENDOCYTOSIS.
    9. Cited for: FUNCTION IN MYOGENESIS, VARIANT EMARDD ARG-774.
    10. Cited for: VARIANTS EMARDD ARG-326 AND ARG-774, VARIANT TRP-71.

    Entry informationi

    Entry nameiMEG10_HUMAN
    AccessioniPrimary (citable) accession number: Q96KG7
    Secondary accession number(s): Q68DE5, Q8WUL3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 13, 2007
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 102 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 5
      Human chromosome 5: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3