Q96KG7 (MEG10_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Multiple epidermal growth factor-like domains protein 10
Short name=Multiple EGF-like domains protein 10

Gene names

Name:	MEGF10
Synonyms:	KIAA1780

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1140 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Membrane receptor involved in phagocytosis by macrophages of apoptotic cells. Cooperates with ABCA1 within the process of engulfment. Promotes the formation of large intracellular vacuoles and may be responsible for the uptake of amyloid-beta peptides. May also function in the mosaic spacing of specific neuron subtypes in the retina through homotypic retinal neuron repulsion. Mosaics provide a mechanism to distribute each cell type evenly across the retina, ensuring that all parts of the visual field have access to a full set of processing elements. May play role in cell adhesion and motility. Is also an essential factor in the regulation of myogenesis. Controls the balance between skeletal muscle satellite cells proliferation and differentiation problably through regulation of the notch signaling pathway. Ref.6 Ref.7 Ref.8 Ref.9
Subunit structure	Homopolymer Probable. Interacts with GULP1 and ABCA1. Interacts with AP2M1. Does not interact with MEGF11. Ref.5 Ref.6 Ref.7
Subcellular location	Cell membrane; Single-pass type I membrane protein. Basolateral cell membrane; Single-pass type I membrane protein. Cell projection › phagocytic cup. Note: Enriched at the sites of contact with apoptotic thymocyte cells By similarity. Forms an irregular, mosaic-like adhesion pattern in region of the cell surface that becomes firmely fixed to the substrate. Expressed at the cell surface in clusters around cell corpses during engulfment. During the engulfment of apoptotic thymocytes, recruited at the bottom of the forming phagocytic cup. Colocalizes with ABCA1 in absence of any phagocytic challenge. Does not localize within lamellipodia. Does not localize with MEGF11. Ref.5 Ref.6
Domain	The EMI and EGF-like domains work in concert to promote self-assembly.
Post-translational modification	Phosphorylated on tyrosine residues. Ref.7 Ubiquitinated; mono- and polyubiquitinated forms are detected. Ref.7
Involvement in disease	Myopathy, early-onset, areflexia, respiratory distress, and dysphagia (EMARDD) [MIM:614399]: An autosomal recessive congenital myopathy characterized by onset at birth, or early in infancy, of respiratory distress caused by diaphragmatic weakness. Additional features are dysphagia resulting in poor feeding, failure to thrive, poor head control, facial weakness, cleft palate, contractures and scoliosis. Affected individuals become ventilator-dependent, and most require feeding by gastrostomy. The disorder results in severe muscle weakness and most patients never achieve walking. Death from respiratory failure in childhood occurs in about half of patients. Muscle biopsies from affected individuals show myopathic changes, replacement of myofibers with fatty tissue, small and incompletely fused muscle fibers, and variation in fiber size. Short regions of sarcomeric disorganization with few or no mitochondria (minicores) have been observed in some cases. Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.9 Ref.10
Sequence similarities	Belongs to the MEGF family. Contains 15 EGF-like domains. Contains 1 EMI domain.
Sequence caution	The sequence BAB47409.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Ontologies

Keywords
Biological process	Cell adhesion Myogenesis Phagocytosis
Cellular component	Cell membrane Cell projection Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Disease	Disease mutation
Domain	EGF-like domain Repeat Signal Transmembrane Transmembrane helix
PTM	Disulfide bond Glycoprotein Ubl conjugation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	homotypic cell-cell adhesion Inferred from direct assay PubMed 22407321. Source: UniProtKB muscle cell development Inferred from mutant phenotype Ref.9. Source: UniProtKB recognition of apoptotic cell Inferred from electronic annotation. Source: Compara regulation of muscle cell differentiation Inferred from mutant phenotype Ref.9. Source: UniProtKB regulation of skeletal muscle tissue development Inferred from mutant phenotype Ref.9. Source: UniProtKB satellite cell activation Inferred from sequence or structural similarity. Source: UniProtKB satellite cell differentiation Inferred from mutant phenotype Ref.9. Source: UniProtKB satellite cell proliferation Inferred from sequence or structural similarity. Source: UniProtKB
Cellular_component	basolateral plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell cell projection Inferred from electronic annotation. Source: UniProtKB-KW integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW phagocytic cup Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q96KG7-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q96KG7-2)

The sequence of this isoform differs from the canonical sequence as follows:
     566-567: VH → LF
     568-1140: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 25	25	Potential
	Chain	26 – 1140	1115	Multiple epidermal growth factor-like domains protein 10		PRO_0000309732
Regions
	Topological domain	26 – 857	832	Extracellular Potential
	Transmembrane	858 – 878	21	Helical; Potential
	Topological domain	879 – 1140	262	Cytoplasmic Potential
	Domain	30 – 107	78	EMI
	Domain	106 – 136	31	EGF-like 1
	Domain	144 – 179	36	EGF-like 2
	Domain	187 – 222	36	EGF-like 3
	Domain	230 – 265	36	EGF-like 4
	Domain	278 – 308	31	EGF-like 5
	Domain	316 – 351	36	EGF-like 6
	Domain	405 – 440	36	EGF-like 7
	Domain	453 – 483	31	EGF-like 8
	Domain	491 – 526	36	EGF-like 9
	Domain	539 – 569	31	EGF-like 10
	Domain	577 – 612	36	EGF-like 11
	Domain	665 – 700	36	EGF-like 12
	Domain	713 – 743	31	EGF-like 13
	Domain	751 – 786	36	EGF-like 14
	Domain	799 – 829	31	EGF-like 15
	Region	1 – 857	857	Necessary for interaction with AP2M1, self-assembly and formation of the irregular, mosaic-like adhesion pattern
	Region	945 – 1140	196	Necessary for formation of large intracellular vacuoles
	Compositional bias	1119 – 1139	21	Ser-rich
Amino acid modifications
	Glycosylation	134	1	N-linked (GlcNAc...) Potential
	Glycosylation	496	1	N-linked (GlcNAc...) Potential
	Disulfide bond	34 ↔ 95		Potential
	Disulfide bond	60 ↔ 69		Potential
	Disulfide bond	94 ↔ 105		Potential
	Disulfide bond	109 ↔ 118		By similarity
	Disulfide bond	113 ↔ 124		By similarity
	Disulfide bond	126 ↔ 135		By similarity
	Disulfide bond	148 ↔ 160		By similarity
	Disulfide bond	154 ↔ 167		By similarity
	Disulfide bond	169 ↔ 178		By similarity
	Disulfide bond	191 ↔ 203		By similarity
	Disulfide bond	197 ↔ 210		By similarity
	Disulfide bond	212 ↔ 221		By similarity
	Disulfide bond	234 ↔ 246		By similarity
	Disulfide bond	240 ↔ 253		By similarity
	Disulfide bond	255 ↔ 264		By similarity
	Disulfide bond	281 ↔ 289		By similarity
	Disulfide bond	283 ↔ 296		By similarity
	Disulfide bond	298 ↔ 307		By similarity
	Disulfide bond	320 ↔ 332		By similarity
	Disulfide bond	326 ↔ 339		By similarity
	Disulfide bond	341 ↔ 350		By similarity
	Disulfide bond	409 ↔ 421		By similarity
	Disulfide bond	415 ↔ 428		By similarity
	Disulfide bond	430 ↔ 439		By similarity
	Disulfide bond	456 ↔ 464		By similarity
	Disulfide bond	458 ↔ 471		By similarity
	Disulfide bond	473 ↔ 482		By similarity
	Disulfide bond	495 ↔ 507		By similarity
	Disulfide bond	501 ↔ 514		By similarity
	Disulfide bond	516 ↔ 525		By similarity
	Disulfide bond	542 ↔ 550		By similarity
	Disulfide bond	544 ↔ 557		By similarity
	Disulfide bond	559 ↔ 568		By similarity
	Disulfide bond	581 ↔ 593		By similarity
	Disulfide bond	587 ↔ 600		By similarity
	Disulfide bond	602 ↔ 611		By similarity
	Disulfide bond	669 ↔ 681		By similarity
	Disulfide bond	675 ↔ 688		By similarity
	Disulfide bond	690 ↔ 699		By similarity
	Disulfide bond	716 ↔ 724		By similarity
	Disulfide bond	718 ↔ 731		By similarity
	Disulfide bond	733 ↔ 742		By similarity
	Disulfide bond	755 ↔ 767		By similarity
	Disulfide bond	761 ↔ 774		By similarity
	Disulfide bond	776 ↔ 785		By similarity
	Disulfide bond	802 ↔ 810		By similarity
	Disulfide bond	804 ↔ 817		By similarity
	Disulfide bond	819 ↔ 828		By similarity
Natural variations
	Alternative sequence	566 – 567	2	VH → LF in isoform 2.		VSP_029244
	Alternative sequence	568 – 1140	573	Missing in isoform 2.		VSP_029245
	Natural variant	71	1	R → W in a patient with EMARDD; unknown pathological significance. Ref.10		VAR_067469
	Natural variant	206	1	V → I. Corresponds to variant rs3812054 [ dbSNP | Ensembl ].		VAR_036988
	Natural variant	326	1	C → R in EMARDD. Ref.10		VAR_067470
	Natural variant	774	1	C → R in EMARDD. Ref.9 Ref.10		VAR_067471
	Natural variant	897	1	P → L. Corresponds to variant rs13183625 [ dbSNP | Ensembl ].		VAR_046377
	Natural variant	1072	1	R → K. Corresponds to variant rs17164935 [ dbSNP | Ensembl ].		VAR_036989
Experimental info
	Mutagenesis	927	1	N → A: Does not interact with GULP1; when associated with A-930. Ref.5
	Mutagenesis	930	1	Y → A: Does not interact with GULP1; when associated with A-927. Ref.5
	Sequence conflict	543	1	D → G in CAH18275. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: 45B2FA239423895A	FASTA	1,140	122,205
	10 20 30 40 50 60 MVISLNSCLS FICLLLCHWI GTASPLNLED PNVCSHWESY SVTVQESYPH PFDQIYYTSC 70 80 90 100 110 120 TDILNWFKCT RHRVSYRTAY RHGEKTMYRR KSQCCPGFYE SGEMCVPHCA DKCVHGRCIA 130 140 150 160 170 180 PNTCQCEPGW GGTNCSSACD GDHWGPHCTS RCQCKNGALC NPITGACHCA AGFRGWRCED 190 200 210 220 230 240 RCEQGTYGND CHQRCQCQNG ATCDHVTGEC RCPPGYTGAF CEDLCPPGKH GPQCEQRCPC 250 260 270 280 290 300 QNGGVCHHVT GECSCPSGWM GTVCGQPCPE GRFGKNCSQE CQCHNGGTCD AATGQCHCSP 310 320 330 340 350 360 GYTGERCQDE CPVGTYGVLC AETCQCVNGG KCYHVSGACL CEAGFAGERC EARLCPEGLY 370 380 390 400 410 420 GIKCDKRCPC HLENTHSCHP MSGECACKPG WSGLYCNETC SPGFYGEACQ QICSCQNGAD 430 440 450 460 470 480 CDSVTGKCTC APGFKGIDCS TPCPLGTYGI NCSSRCGCKN DAVCSPVDGS CTCKAGWHGV 490 500 510 520 530 540 DCSIRCPSGT WGFGCNLTCQ CLNGGACNTL DGTCTCAPGW RGEKCELPCQ DGTYGLNCAE 550 560 570 580 590 600 RCDCSHADGC HPTTGHCRCL PGWSGVHCDS VCAEGRWGPN CSLPCYCKNG ASCSPDDGIC 610 620 630 640 650 660 ECAPGFRGTT CQRICSPGFY GHRCSQTCPQ CVHSSGPCHH ITGLCDCLPG FTGALCNEVC 670 680 690 700 710 720 PSGRFGKNCA GICTCTNNGT CNPIDRSCQC YPGWIGSDCS QPCPPAHWGP NCIHTCNCHN 730 740 750 760 770 780 GAFCSAYDGE CKCTPGWTGL YCTQRCPLGF YGKDCALICQ CQNGADCDHI SGQCTCRTGF 790 800 810 820 830 840 MGRHCEQKCP SGTYGYGCRQ ICDCLNNSTC DHITGTCYCS PGWKGARCDQ AGVIIVGNLN 850 860 870 880 890 900 SLSRTSTALP ADSYQIGAIA GIIILVLVVL FLLALFIIYR HKQKGKESSM PAVTYTPAMR 910 920 930 940 950 960 VVNADYTISG TLPHSNGGNA NSHYFTNPSY HTLTQCATSP HVNNRDRMTV TKSKNNQLFV 970 980 990 1000 1010 1020 NLKNVNPGKR GPVGDCTGTL PADWKHGGYL NELGAFGLDR SYMGKSLKDL GKNSEYNSSN 1030 1040 1050 1060 1070 1080 CSLSSSENPY ATIKDPPVLI PKSSECGYVE MKSPARRDSP YAEINNSTSA NRNVYEVEPT 1090 1100 1110 1120 1130 1140 VSVVQGVFSN NGRLSQDPYD LPKNSHIPCH YDLLPVRDSS SSPKQEDSGG SSSNSSSSSE
	Isoform 2 [UniParc]. Checksum: CF2FB8CDEB7CF627	FASTA	567	60,797
	10 20 30 40 50 60 MVISLNSCLS FICLLLCHWI GTASPLNLED PNVCSHWESY SVTVQESYPH PFDQIYYTSC 70 80 90 100 110 120 TDILNWFKCT RHRVSYRTAY RHGEKTMYRR KSQCCPGFYE SGEMCVPHCA DKCVHGRCIA 130 140 150 160 170 180 PNTCQCEPGW GGTNCSSACD GDHWGPHCTS RCQCKNGALC NPITGACHCA AGFRGWRCED 190 200 210 220 230 240 RCEQGTYGND CHQRCQCQNG ATCDHVTGEC RCPPGYTGAF CEDLCPPGKH GPQCEQRCPC 250 260 270 280 290 300 QNGGVCHHVT GECSCPSGWM GTVCGQPCPE GRFGKNCSQE CQCHNGGTCD AATGQCHCSP 310 320 330 340 350 360 GYTGERCQDE CPVGTYGVLC AETCQCVNGG KCYHVSGACL CEAGFAGERC EARLCPEGLY 370 380 390 400 410 420 GIKCDKRCPC HLENTHSCHP MSGECACKPG WSGLYCNETC SPGFYGEACQ QICSCQNGAD 430 440 450 460 470 480 CDSVTGKCTC APGFKGIDCS TPCPLGTYGI NCSSRCGCKN DAVCSPVDGS CTCKAGWHGV 490 500 510 520 530 540 DCSIRCPSGT WGFGCNLTCQ CLNGGACNTL DGTCTCAPGW RGEKCELPCQ DGTYGLNCAE 550 560 RCDCSHADGC HPTTGHCRCL PGWSGLF

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Nakayama M., Nakajima D., Kikuno R., Ohara O. DNA Res. 8:85-95(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Brain.
[2]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Retina.
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Muscle.
[5]	"Cooperation between engulfment receptors: the case of ABCA1 and MEGF10." Hamon Y., Trompier D., Ma Z., Venegas V., Pophillat M., Mignotte V., Zhou Z., Chimini G. PLoS ONE 1:E120-E120(2006) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH GULP1 AND ABCA1, MUTAGENESIS OF ASN-927 AND TYR-930, SUBCELLULAR LOCATION.
[6]	"The mammalian Ced-1 ortholog MEGF10/KIAA1780 displays a novel adhesion pattern." Suzuki E., Nakayama M. Exp. Cell Res. 313:2451-2464(2007) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, SUBUNIT, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
[7]	"MEGF10 is a mammalian ortholog of CED-1 that interacts with clathrin assembly protein complex 2 medium chain and induces large vacuole formation." Suzuki E., Nakayama M. Exp. Cell Res. 313:3729-3742(2007) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, MASS SPECTROMETRY, INTERACTION WITH AP2M1 AND GULP1, PHOSPHORYLATION, UBIQUITINATION.
[8]	"MEGF10 functions as a receptor for the uptake of amyloid-beta." Singh T.D., Park S.Y., Bae J.S., Yun Y., Bae Y.C., Park R.W., Kim I.S. FEBS Lett. 584:3936-3942(2010) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION IN ENDOCYTOSIS.
[9]	"Mutations in MEGF10, a regulator of satellite cell myogenesis, cause early onset myopathy, areflexia, respiratory distress and dysphagia (EMARDD)." Logan C.V., Lucke B., Pottinger C., Abdelhamed Z.A., Parry D.A., Szymanska K., Diggle C.P., Riesen A., Morgan J.E., Markham G., Ellis I., Manzur A.Y., Markham A.F., Shires M., Helliwell T., Scoto M., Hubner C., Bonthron D.T. , Taylor G.R., Sheridan E., Muntoni F., Carr I.M., Schuelke M., Johnson C.A. Nat. Genet. 43:1189-1192(2011) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION IN MYOGENESIS, VARIANT EMARDD ARG-774.
[10]	"Mutations in the satellite cell gene MEGF10 cause a recessive congenital myopathy with minicores." Boyden S.E., Mahoney L.J., Kawahara G., Myers J.A., Mitsuhashi S., Estrella E.A., Duncan A.R., Dey F., Dechene E.T., Blasko-Goehringer J.M., Bonnemann C.G., Darras B.T., Mendell J.R., Lidov H.G., Nishino I., Beggs A.H., Kunkel L.M., Kang P.B. Neurogenetics 13:115-124(2012) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANTS EMARDD ARG-326 AND ARG-774, VARIANT TRP-71.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB058676 mRNA. Translation: BAB47409.2. Different initiation. CR749437 mRNA. Translation: CAH18275.1. CH471062 Genomic DNA. Translation: EAW62406.1. BC020198 mRNA. Translation: AAH20198.1. BC152478 mRNA. Translation: AAI52479.1.
IPI	IPI00064607. IPI00873983.
RefSeq	NP_001243474.1. NM_001256545.1. NP_115822.1. NM_032446.2.
UniGene	Hs.438709.
3D structure databases
HSSP	HSSP built from PDB template 1EGF based on UniProtKB P01132.
ProteinModelPortal	Q96KG7.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q96KG7. 24 interactions.
STRING	9606.ENSP00000274473.
PTM databases
PhosphoSite	Q96KG7.
Polymorphism databases
DMDM	74716908.
Proteomic databases
PaxDb	Q96KG7.
PRIDE	Q96KG7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000274473; ENSP00000274473; ENSG00000145794. ENST00000418761; ENSP00000416284; ENSG00000145794. ENST00000503335; ENSP00000423354; ENSG00000145794. ENST00000508365; ENSP00000423195; ENSG00000145794.
GeneID	84466.
KEGG	hsa:84466.
UCSC	uc003kuh.4. human. uc010jdc.1. human.
Organism-specific databases
CTD	84466.
GeneCards	GC05P126654.
HGNC	HGNC:29634. MEGF10.
HPA	HPA026876.
MIM	612453. gene. 614399. phenotype.
neXtProt	NX_Q96KG7.
Orphanet	98920. Spinal muscular atrophy with respiratory distress.
PharmGKB	PA144596410.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG12793.
HOGENOM	HOG000294130.
HOVERGEN	HBG108333.
InParanoid	Q96KG7.
OMA	FGCNLTC.
PhylomeDB	Q96KG7.
Gene expression databases
Bgee	Q96KG7.
CleanEx	HS_MEGF10.
Genevestigator	Q96KG7.
Family and domain databases
InterPro	IPR000742. EG-like_dom. IPR013032. EGF-like_CS. IPR002049. EGF_laminin. IPR011489. EMI_domain. [Graphical view]
Pfam	PF12661. hEGF. 3 hits. PF00053. Laminin_EGF. 6 hits. [Graphical view]
SMART	SM00181. EGF. 11 hits. SM00180. EGF_Lam. 6 hits. [Graphical view]
PROSITE	PS00022. EGF_1. 17 hits. PS01186. EGF_2. 17 hits. PS50026. EGF_3. 15 hits. PS51041. EMI. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	84466.
NextBio	74274.
SOURCE	Search...

Entry information

Entry name

MEG10_HUMAN

Accession

Primary (citable) accession number: Q96KG7
Secondary accession number(s): Q68DE5, Q8WUL3

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 13, 2007
Last sequence update:	December 1, 2001
Last modified:	May 1, 2013
This is version 89 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.