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Protein

Small integral membrane protein 8

Gene

SMIM8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Enzyme and pathway databases

BioCyciZFISH:ENSG00000111850-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Small integral membrane protein 8
Gene namesi
Name:SMIM8
Synonyms:C6orf162
ORF Names:DC18
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:21401. SMIM8.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei48 – 70HelicalSequence analysisAdd BLAST23

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000111850.
PharmGKBiPA134961667.

Polymorphism and mutation databases

BioMutaiSMIM8.
DMDMi71152382.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000895501 – 97Small integral membrane protein 8Add BLAST97

Proteomic databases

EPDiQ96KF7.
MaxQBiQ96KF7.
PaxDbiQ96KF7.
PeptideAtlasiQ96KF7.
PRIDEiQ96KF7.
TopDownProteomicsiQ96KF7.

PTM databases

iPTMnetiQ96KF7.
PhosphoSitePlusiQ96KF7.

Expressioni

Gene expression databases

BgeeiENSG00000111850.
CleanExiHS_C6orf162.
ExpressionAtlasiQ96KF7. baseline and differential.
GenevisibleiQ96KF7. HS.

Organism-specific databases

HPAiHPA007401.

Interactioni

Protein-protein interaction databases

BioGridi121407. 1 interactor.
STRINGi9606.ENSP00000229570.

Structurei

3D structure databases

ProteinModelPortaliQ96KF7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SMIM8 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J16W. Eukaryota.
ENOG4111ZT4. LUCA.
GeneTreeiENSGT00390000011674.
HOGENOMiHOG000231910.
HOVERGENiHBG080482.
InParanoidiQ96KF7.
OMAiTLCVGYL.
OrthoDBiEOG091G12UI.
PhylomeDBiQ96KF7.
TreeFamiTF323863.

Family and domain databases

InterProiIPR026686. UPF0708.
[Graphical view]
PANTHERiPTHR14274. PTHR14274. 1 hit.
PfamiPF14937. DUF4500. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96KF7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSAPEPPTF KKEPPKEKEF QSPGLRGVRT TTLFRAVNPE LFIKPNKPVM
60 70 80 90
AFGLVTLSLC VAYIGYLHAI QENKKDLYEA IDSEGHSYMR RKTSKWD
Length:97
Mass (Da):11,059
Last modified:July 19, 2005 - v2
Checksum:i50F00DE39A4C306F
GO

Sequence cautioni

The sequence AAK38513 differs from that shown. Reason: Frameshift at position 87.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF311339 mRNA. Translation: AAK38513.1. Frameshift.
AK311963 mRNA. Translation: BAG34903.1.
AL096817 Genomic DNA. Translation: CAI18941.2.
CH471051 Genomic DNA. Translation: EAW48602.1.
CH471051 Genomic DNA. Translation: EAW48603.1.
BC070260 mRNA. Translation: AAH70260.1.
CCDSiCCDS34496.1.
RefSeqiNP_001035958.1. NM_001042493.2.
NP_065158.3. NM_020425.5.
UniGeneiHs.70769.

Genome annotation databases

EnsembliENST00000229570; ENSP00000229570; ENSG00000111850.
ENST00000392863; ENSP00000376603; ENSG00000111850.
ENST00000608353; ENSP00000477133; ENSG00000111850.
ENST00000608868; ENSP00000476945; ENSG00000111850.
GeneIDi57150.
KEGGihsa:57150.
UCSCiuc003plp.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF311339 mRNA. Translation: AAK38513.1. Frameshift.
AK311963 mRNA. Translation: BAG34903.1.
AL096817 Genomic DNA. Translation: CAI18941.2.
CH471051 Genomic DNA. Translation: EAW48602.1.
CH471051 Genomic DNA. Translation: EAW48603.1.
BC070260 mRNA. Translation: AAH70260.1.
CCDSiCCDS34496.1.
RefSeqiNP_001035958.1. NM_001042493.2.
NP_065158.3. NM_020425.5.
UniGeneiHs.70769.

3D structure databases

ProteinModelPortaliQ96KF7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121407. 1 interactor.
STRINGi9606.ENSP00000229570.

PTM databases

iPTMnetiQ96KF7.
PhosphoSitePlusiQ96KF7.

Polymorphism and mutation databases

BioMutaiSMIM8.
DMDMi71152382.

Proteomic databases

EPDiQ96KF7.
MaxQBiQ96KF7.
PaxDbiQ96KF7.
PeptideAtlasiQ96KF7.
PRIDEiQ96KF7.
TopDownProteomicsiQ96KF7.

Protocols and materials databases

DNASUi57150.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000229570; ENSP00000229570; ENSG00000111850.
ENST00000392863; ENSP00000376603; ENSG00000111850.
ENST00000608353; ENSP00000477133; ENSG00000111850.
ENST00000608868; ENSP00000476945; ENSG00000111850.
GeneIDi57150.
KEGGihsa:57150.
UCSCiuc003plp.2. human.

Organism-specific databases

CTDi57150.
GeneCardsiSMIM8.
H-InvDBHIX0200836.
HGNCiHGNC:21401. SMIM8.
HPAiHPA007401.
neXtProtiNX_Q96KF7.
OpenTargetsiENSG00000111850.
PharmGKBiPA134961667.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J16W. Eukaryota.
ENOG4111ZT4. LUCA.
GeneTreeiENSGT00390000011674.
HOGENOMiHOG000231910.
HOVERGENiHBG080482.
InParanoidiQ96KF7.
OMAiTLCVGYL.
OrthoDBiEOG091G12UI.
PhylomeDBiQ96KF7.
TreeFamiTF323863.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000111850-MONOMER.

Miscellaneous databases

GenomeRNAii57150.
PROiQ96KF7.

Gene expression databases

BgeeiENSG00000111850.
CleanExiHS_C6orf162.
ExpressionAtlasiQ96KF7. baseline and differential.
GenevisibleiQ96KF7. HS.

Family and domain databases

InterProiIPR026686. UPF0708.
[Graphical view]
PANTHERiPTHR14274. PTHR14274. 1 hit.
PfamiPF14937. DUF4500. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSMIM8_HUMAN
AccessioniPrimary (citable) accession number: Q96KF7
Secondary accession number(s): B2R4V6
, E1P505, Q5TEZ3, Q6NSD2, Q8IZ10
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: July 19, 2005
Last modified: November 2, 2016
This is version 95 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.