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Protein

Small nuclear protein PRAC1

Gene

PRAC1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Small nuclear protein PRAC1
Alternative name(s):
Prostate cancer susceptibility candidate protein 1
Prostate, rectum and colon expressed gene protein
Gene namesi
Name:PRAC1
Synonyms:C17orf92, PRAC
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:30591. PRAC1.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi84366.
OpenTargetsiENSG00000159182.
PharmGKBiPA164725009.

Polymorphism and mutation databases

BioMutaiPRAC1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003124171 – 57Small nuclear protein PRAC1Add BLAST57

Proteomic databases

PaxDbiQ96KF2.
PRIDEiQ96KF2.

PTM databases

iPTMnetiQ96KF2.
PhosphoSitePlusiQ96KF2.

Expressioni

Tissue specificityi

Highly expressed in prostate, rectum, and distal colon, and weakly expressed in bladder. Expressed in prostate cancer cell lines.1 Publication

Gene expression databases

BgeeiENSG00000159182.
CleanExiHS_PRAC.
GenevisibleiQ96KF2. HS.

Organism-specific databases

HPAiHPA047871.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000290294.

Structurei

3D structure databases

ProteinModelPortaliQ96KF2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410IV1Y. Eukaryota.
ENOG4110PPZ. LUCA.
GeneTreeiENSGT00390000010034.
HOGENOMiHOG000115683.
InParanoidiQ96KF2.
OMAiCNSRILG.
OrthoDBiEOG091G17TI.
PhylomeDBiQ96KF2.
TreeFamiTF341666.

Sequencei

Sequence statusi: Complete.

Q96KF2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLCAHFSDQG PAHLTTSKSA FLSNKKTSTL KHLLGETRSD GSACNSGISG

GRGRKIP
Length:57
Mass (Da):5,959
Last modified:December 1, 2001 - v1
Checksum:iA460DC3FDAB1A49D
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0512854A → V. Corresponds to variant dbSNP:rs34734055Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF331165 mRNA. Translation: AAK38837.1.
AC091179 Genomic DNA. No translation available.
CH471109 Genomic DNA. Translation: EAW94717.1.
BC030950 mRNA. Translation: AAH30950.1.
CCDSiCCDS11535.1.
RefSeqiNP_115767.1. NM_032391.2.
UniGeneiHs.116467.

Genome annotation databases

EnsembliENST00000290294; ENSP00000290294; ENSG00000159182.
GeneIDi84366.
KEGGihsa:84366.
UCSCiuc002iny.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiPRAC1_HUMAN
AccessioniPrimary (citable) accession number: Q96KF2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: December 1, 2001
Last modified: March 15, 2017
This is version 90 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot