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Protein

Small nuclear protein PRAC1

Gene

PRAC1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Small nuclear protein PRAC1
Alternative name(s):
Prostate cancer susceptibility candidate protein 1
Prostate, rectum and colon expressed gene protein
Gene namesi
Name:PRAC1
Synonyms:C17orf92, PRAC
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:30591. PRAC1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA164725009.

Polymorphism and mutation databases

BioMutaiPRAC1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 5757Small nuclear protein PRAC1PRO_0000312417Add
BLAST

Proteomic databases

PaxDbiQ96KF2.
PRIDEiQ96KF2.

PTM databases

iPTMnetiQ96KF2.

Expressioni

Tissue specificityi

Highly expressed in prostate, rectum, and distal colon, and weakly expressed in bladder. Expressed in prostate cancer cell lines.1 Publication

Gene expression databases

BgeeiQ96KF2.
CleanExiHS_PRAC.
GenevisibleiQ96KF2. HS.

Organism-specific databases

HPAiHPA047871.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000290294.

Structurei

3D structure databases

ProteinModelPortaliQ96KF2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410IV1Y. Eukaryota.
ENOG4110PPZ. LUCA.
GeneTreeiENSGT00390000010034.
HOGENOMiHOG000115683.
InParanoidiQ96KF2.
OMAiCNSRILG.
OrthoDBiEOG7WT44D.
PhylomeDBiQ96KF2.
TreeFamiTF341666.

Sequencei

Sequence statusi: Complete.

Q96KF2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLCAHFSDQG PAHLTTSKSA FLSNKKTSTL KHLLGETRSD GSACNSGISG

GRGRKIP
Length:57
Mass (Da):5,959
Last modified:December 1, 2001 - v1
Checksum:iA460DC3FDAB1A49D
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti4 – 41A → V.
Corresponds to variant rs34734055 [ dbSNP | Ensembl ].
VAR_051285

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF331165 mRNA. Translation: AAK38837.1.
AC091179 Genomic DNA. No translation available.
CH471109 Genomic DNA. Translation: EAW94717.1.
BC030950 mRNA. Translation: AAH30950.1.
CCDSiCCDS11535.1.
RefSeqiNP_115767.1. NM_032391.2.
UniGeneiHs.116467.

Genome annotation databases

EnsembliENST00000290294; ENSP00000290294; ENSG00000159182.
GeneIDi84366.
KEGGihsa:84366.
UCSCiuc002iny.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF331165 mRNA. Translation: AAK38837.1.
AC091179 Genomic DNA. No translation available.
CH471109 Genomic DNA. Translation: EAW94717.1.
BC030950 mRNA. Translation: AAH30950.1.
CCDSiCCDS11535.1.
RefSeqiNP_115767.1. NM_032391.2.
UniGeneiHs.116467.

3D structure databases

ProteinModelPortaliQ96KF2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000290294.

PTM databases

iPTMnetiQ96KF2.

Polymorphism and mutation databases

BioMutaiPRAC1.

Proteomic databases

PaxDbiQ96KF2.
PRIDEiQ96KF2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000290294; ENSP00000290294; ENSG00000159182.
GeneIDi84366.
KEGGihsa:84366.
UCSCiuc002iny.4. human.

Organism-specific databases

CTDi84366.
GeneCardsiPRAC1.
HGNCiHGNC:30591. PRAC1.
HPAiHPA047871.
MIMi609819. gene.
neXtProtiNX_Q96KF2.
PharmGKBiPA164725009.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IV1Y. Eukaryota.
ENOG4110PPZ. LUCA.
GeneTreeiENSGT00390000010034.
HOGENOMiHOG000115683.
InParanoidiQ96KF2.
OMAiCNSRILG.
OrthoDBiEOG7WT44D.
PhylomeDBiQ96KF2.
TreeFamiTF341666.

Miscellaneous databases

GenomeRNAii84366.
PROiQ96KF2.
SOURCEiSearch...

Gene expression databases

BgeeiQ96KF2.
CleanExiHS_PRAC.
GenevisibleiQ96KF2. HS.

Family and domain databases

ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "PRAC: a novel small nuclear protein that is specifically expressed in human prostate and colon."
    Liu X.F., Olsson P., Wolfgang C.D., Bera T.K., Duray P., Lee B., Pastan I.
    Prostate 47:125-131(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    Tissue: Prostate.
  2. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
    Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
    , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
    Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Prostate.

Entry informationi

Entry nameiPRAC1_HUMAN
AccessioniPrimary (citable) accession number: Q96KF2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: December 1, 2001
Last modified: June 8, 2016
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.