Reviewed, UniProtKB/Swiss-Prot Q96KD8 (LSCR1_HUMAN)

Names and origin

Protein names

Recommended name:
    Lung squamous cell carcinoma-related protein 1

Gene names

Name:

C18orf50

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	94 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Subcellular location	Membrane; Single-pass membrane protein Potential.
Tissue specificity	Strongly expressed in lung squamous cell carcinoma as compared to normal tissue. Ref.1

Ontologies

Keywords
Cellular component	Membrane
Domain	Transmembrane
Technical term	Complete proteome
Gene Ontology (GO)
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 94	94	Lung squamous cell carcinoma-related protein 1		PRO_0000286710
Regions
	Transmembrane	70 – 90	21	Potential
	Compositional bias	60 – 77	18	Phe-rich

Sequences

	Sequence		Length	Mass (Da)
	Q96KD8-1 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: 28373A309F31F8AF	FASTA	94	11,110
	10 20 30 40 50 60 MSDDNIKKEA HIDANSSTYM IIFFISKGLR AVYTKPSYQA DHNQFTGWIS HGTQARKCTF 70 80 90 FFFFFCKNYF IISYFFFIGW GLTILPSLVF NFRL

References

[1]

"Molecular cloning, identification and analysis of lung squamous cell carcinoma-related genes." Shen C.Y., Hui-Zhao X., Wang D., Jiang G.C., Wang J., Zhang G.L. Lung Cancer 38:235-241(2002) [PubMed: 12445744] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY. Tissue: Lung carcinoma.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF363068 mRNA. Translation: AAK51085.1.
IPI	IPI00386915.
UniGene	Hs.653395
3D structure databases
ModBase	Search...
Organism-specific databases
GeneCards	GC18U900254.
HGNC	HGNC:31727. C18orf50.
PharmGKB	PA142672217.
GenAtlas	Search...
Gene expression databases
Genevestigator	Q96KD8.
Family and domain databases
ProtoNet	Search...

Entry information

Entry name

LSCR1_HUMAN

Accession

Primary (citable) accession number: Q96KD8

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 15, 2007
Last sequence update:	December 1, 2001
Last modified:	October 13, 2009
This is version 32 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.