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Protein

ADP-ribosylation factor-like protein 5B

Gene

ARL5B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Binds and exchanges GTP and GDP.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei31 – 311GTP
Binding sitei159 – 1591GTP; via amide nitrogen

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi23 – 308GTP
Nucleotide bindingi66 – 705GTPBy similarity
Nucleotide bindingi125 – 1284GTP

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
ADP-ribosylation factor-like protein 5B
Alternative name(s):
ADP-ribosylation factor-like protein 8
Gene namesi
Name:ARL5B
Synonyms:ARL8
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:23052. ARL5B.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134979161.

Polymorphism and mutation databases

BioMutaiARL5B.
DMDMi34922029.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedSequence analysis
Chaini2 – 179178ADP-ribosylation factor-like protein 5BPRO_0000207470Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi2 – 21N-myristoyl glycineSequence analysis

Keywords - PTMi

Lipoprotein, Myristate

Proteomic databases

EPDiQ96KC2.
MaxQBiQ96KC2.
PaxDbiQ96KC2.
PRIDEiQ96KC2.

PTM databases

iPTMnetiQ96KC2.
PhosphoSiteiQ96KC2.

Expressioni

Gene expression databases

BgeeiQ96KC2.
CleanExiHS_ARL5B.
ExpressionAtlasiQ96KC2. baseline and differential.
GenevisibleiQ96KC2. HS.

Organism-specific databases

HPAiHPA027002.

Interactioni

Protein-protein interaction databases

BioGridi128683. 17 interactions.
STRINGi9606.ENSP00000366487.

Structurei

Secondary structure

1
179
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi7 – 148Combined sources
Beta strandi18 – 236Combined sources
Helixi29 – 379Combined sources
Beta strandi53 – 575Combined sources
Beta strandi60 – 667Combined sources
Helixi71 – 777Combined sources
Helixi78 – 814Combined sources
Beta strandi86 – 927Combined sources
Helixi96 – 983Combined sources
Helixi99 – 11012Combined sources
Helixi113 – 1153Combined sources
Beta strandi119 – 1257Combined sources
Helixi135 – 1417Combined sources
Helixi144 – 1463Combined sources
Beta strandi152 – 1565Combined sources
Turni159 – 1624Combined sources
Helixi165 – 1728Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1YZGX-ray2.00A1-179[»]
ProteinModelPortaliQ96KC2.
SMRiQ96KC2. Positions 6-173.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ96KC2.

Family & Domainsi

Sequence similaritiesi

Belongs to the small GTPase superfamily. Arf family.Curated

Phylogenomic databases

eggNOGiKOG0070. Eukaryota.
COG1100. LUCA.
GeneTreeiENSGT00780000121855.
HOGENOMiHOG000163691.
HOVERGENiHBG002073.
InParanoidiQ96KC2.
KOiK07950.
OMAiEWMTSRA.
OrthoDBiEOG7VHSZV.
PhylomeDBiQ96KC2.
TreeFamiTF105465.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR024156. Small_GTPase_ARF.
IPR006689. Small_GTPase_ARF/SAR.
[Graphical view]
PfamiPF00025. Arf. 1 hit.
[Graphical view]
PRINTSiPR00328. SAR1GTPBP.
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51417. ARF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q96KC2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLIFAKLWS LFCNQEHKVI IVGLDNAGKT TILYQFLMNE VVHTSPTIGS
60 70 80 90 100
NVEEIVVKNT HFLMWDIGGQ ESLRSSWNTY YSNTEFIILV VDSIDRERLA
110 120 130 140 150
ITKEELYRML AHEDLRKAAV LIFANKQDMK GCMTAAEISK YLTLSSIKDH
160 170
PWHIQSCCAL TGEGLCQGLE WMTSRIGVR
Length:179
Mass (Da):20,375
Last modified:December 1, 2001 - v1
Checksum:iECD74C4EA1A80E33
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF494061 mRNA. Translation: AAM74076.1.
AK027275 mRNA. Translation: BAB55011.1.
BC024163 mRNA. Translation: AAH24163.1.
CCDSiCCDS7131.1.
RefSeqiNP_848930.1. NM_178815.3.
UniGeneiHs.25362.
Hs.594569.

Genome annotation databases

EnsembliENST00000377275; ENSP00000366487; ENSG00000165997.
GeneIDi221079.
KEGGihsa:221079.
UCSCiuc001iqd.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF494061 mRNA. Translation: AAM74076.1.
AK027275 mRNA. Translation: BAB55011.1.
BC024163 mRNA. Translation: AAH24163.1.
CCDSiCCDS7131.1.
RefSeqiNP_848930.1. NM_178815.3.
UniGeneiHs.25362.
Hs.594569.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1YZGX-ray2.00A1-179[»]
ProteinModelPortaliQ96KC2.
SMRiQ96KC2. Positions 6-173.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi128683. 17 interactions.
STRINGi9606.ENSP00000366487.

PTM databases

iPTMnetiQ96KC2.
PhosphoSiteiQ96KC2.

Polymorphism and mutation databases

BioMutaiARL5B.
DMDMi34922029.

Proteomic databases

EPDiQ96KC2.
MaxQBiQ96KC2.
PaxDbiQ96KC2.
PRIDEiQ96KC2.

Protocols and materials databases

DNASUi221079.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000377275; ENSP00000366487; ENSG00000165997.
GeneIDi221079.
KEGGihsa:221079.
UCSCiuc001iqd.2. human.

Organism-specific databases

CTDi221079.
GeneCardsiARL5B.
HGNCiHGNC:23052. ARL5B.
HPAiHPA027002.
MIMi608909. gene.
neXtProtiNX_Q96KC2.
PharmGKBiPA134979161.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0070. Eukaryota.
COG1100. LUCA.
GeneTreeiENSGT00780000121855.
HOGENOMiHOG000163691.
HOVERGENiHBG002073.
InParanoidiQ96KC2.
KOiK07950.
OMAiEWMTSRA.
OrthoDBiEOG7VHSZV.
PhylomeDBiQ96KC2.
TreeFamiTF105465.

Miscellaneous databases

EvolutionaryTraceiQ96KC2.
GenomeRNAii221079.
NextBioi91187.
PROiQ96KC2.
SOURCEiSearch...

Gene expression databases

BgeeiQ96KC2.
CleanExiHS_ARL5B.
ExpressionAtlasiQ96KC2. baseline and differential.
GenevisibleiQ96KC2. HS.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR024156. Small_GTPase_ARF.
IPR006689. Small_GTPase_ARF/SAR.
[Graphical view]
PfamiPF00025. Arf. 1 hit.
[Graphical view]
PRINTSiPR00328. SAR1GTPBP.
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51417. ARF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation of a new member of the ADP-ribosylation like factor gene family, ARL8, from a cartilage cDNA library."
    Sebald E., Krueger R., King L.M., Cohn D.H., Krakow D.
    Gene 311:147-151(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Fetal cartilage.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Embryo.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Prostatic adenocarcinoma.
  4. "Structure of human ADP-ribosylation factor-like 8."
    Structural genomics consortium (SGC)
    Submitted (JUN-2005) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) IN COMPLEX WITH GDP.

Entry informationi

Entry nameiARL5B_HUMAN
AccessioniPrimary (citable) accession number: Q96KC2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2003
Last sequence update: December 1, 2001
Last modified: May 11, 2016
This is version 127 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.