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Q96KB5

- TOPK_HUMAN

UniProt

Q96KB5 - TOPK_HUMAN

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Protein

Lymphokine-activated killer T-cell-originated protein kinase

Gene
PBK, TOPK
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Phosphorylates MAP kinase p38. Seems to be active only in mitosis. May also play a role in the activation of lymphoid cells. When phosphorylated, forms a complex with TP53, leading to TP53 destabilization and attenuation of G2/M checkpoint during doxorubicin-induced DNA damage.2 Publications

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Enzyme regulationi

Activated by phosphorylation By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei64 – 641ATP By similarity
Active sitei167 – 1671Proton acceptor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi38 – 469ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: InterPro
  2. protein binding Source: UniProtKB
  3. protein serine/threonine kinase activity Source: InterPro

GO - Biological processi

  1. mitotic nuclear division Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

SignaLinkiQ96KB5.

Names & Taxonomyi

Protein namesi
Recommended name:
Lymphokine-activated killer T-cell-originated protein kinase (EC:2.7.12.2)
Alternative name(s):
Cancer/testis antigen 84
Short name:
CT84
MAPKK-like protein kinase
Nori-3
PDZ-binding kinase
Spermatogenesis-related protein kinase
Short name:
SPK
T-LAK cell-originated protein kinase
Gene namesi
Name:PBK
Synonyms:TOPK
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 8

Organism-specific databases

HGNCiHGNC:18282. PBK.

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi9 – 91T → E: TP53-binding. 1 Publication
Mutagenesisi64 – 652KK → AA: Loss of activity.
Mutagenesisi320 – 3201T → A: Decrease in the binding to DLG1. 1 Publication
Mutagenesisi322 – 3221V → A: Decrease in the binding to DLG1. 1 Publication

Organism-specific databases

PharmGKBiPA134925802.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 322322Lymphokine-activated killer T-cell-originated protein kinasePRO_0000086763Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionine3 Publications
Modified residuei9 – 91Phosphothreonine1 Publication
Modified residuei24 – 241Phosphothreonine1 Publication
Modified residuei32 – 321Phosphoserine2 Publications
Modified residuei59 – 591Phosphoserine2 Publications

Post-translational modificationi

Phosphorylated; in a cell-cycle dependent manner at mitosis.2 Publications

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ96KB5.
PaxDbiQ96KB5.
PeptideAtlasiQ96KB5.
PRIDEiQ96KB5.

PTM databases

PhosphoSiteiQ96KB5.

Expressioni

Tissue specificityi

Expressed in the testis and placenta. In the testis, restrictedly expressed in outer cell layer of seminiferous tubules.2 Publications

Gene expression databases

ArrayExpressiQ96KB5.
BgeeiQ96KB5.
CleanExiHS_PBK.
GenevestigatoriQ96KB5.

Organism-specific databases

HPAiHPA005753.

Interactioni

Subunit structurei

Interacts with DLG1 and TP53.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
ARAFP103983EBI-536853,EBI-365961
TP53P046377EBI-536853,EBI-366083

Protein-protein interaction databases

BioGridi120971. 14 interactions.
IntActiQ96KB5. 9 interactions.
MINTiMINT-130347.
STRINGi9606.ENSP00000301905.

Structurei

3D structure databases

ProteinModelPortaliQ96KB5.
SMRiQ96KB5. Positions 34-316.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini32 – 322291Protein kinaseAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni320 – 3223PDZ-interaction

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0515.
HOGENOMiHOG000294208.
HOVERGENiHBG056011.
InParanoidiQ96KB5.
KOiK08865.
OrthoDBiEOG7S4X6F.
PhylomeDBiQ96KB5.
TreeFamiTF329763.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q96KB5-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MEGISNFKTP SKLSEKKKSV LCSTPTINIP ASPFMQKLGF GTGVNVYLMK    50
RSPRGLSHSP WAVKKINPIC NDHYRSVYQK RLMDEAKILK SLHHPNIVGY 100
RAFTEANDGS LCLAMEYGGE KSLNDLIEER YKASQDPFPA AIILKVALNM 150
ARGLKYLHQE KKLLHGDIKS SNVVIKGDFE TIKICDVGVS LPLDENMTVT 200
DPEACYIGTE PWKPKEAVEE NGVITDKADI FAFGLTLWEM MTLSIPHINL 250
SNDDDDEDKT FDESDFDDEA YYAALGTRPP INMEELDESY QKVIELFSVC 300
TNEDPKDRPS AAHIVEALET DV 322
Length:322
Mass (Da):36,085
Last modified:December 6, 2005 - v3
Checksum:i6BF55789BC204ABE
GO
Isoform 2 (identifier: Q96KB5-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     198-198: T → TAPAFITILLVS

Note: No experimental confirmation available.

Show »
Length:333
Mass (Da):37,211
Checksum:i05A472E8DD4D9928
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti107 – 1071N → S.4 Publications
Corresponds to variant rs3779620 [ dbSNP | Ensembl ].
VAR_021162
Natural varianti220 – 2201E → D.
Corresponds to variant rs17057901 [ dbSNP | Ensembl ].
VAR_051676
Natural varianti241 – 2411M → L.1 Publication
Corresponds to variant rs36086402 [ dbSNP | Ensembl ].
VAR_041234

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei198 – 1981T → TAPAFITILLVS in isoform 2. VSP_055269

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti34 – 341F → I in AAF71521. 1 Publication
Sequence conflicti169 – 1691K → E in BAB55019. 1 Publication
Sequence conflicti254 – 2541D → N in BAB55019. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB027249 mRNA. Translation: BAA99576.1.
AB027250 mRNA. Translation: BAA99577.1.
AF189722 mRNA. Translation: AAF69107.1.
AF237709 mRNA. Translation: AAF71521.1.
AK027291 mRNA. Translation: BAB55019.1.
AK301836 mRNA. Translation: BAG63280.1.
AC104997 Genomic DNA. No translation available.
CH471080 Genomic DNA. Translation: EAW63536.1.
CH471080 Genomic DNA. Translation: EAW63537.1.
BC015191 mRNA. Translation: AAH15191.1.
CCDSiCCDS6063.1. [Q96KB5-1]
RefSeqiNP_001265874.1. NM_001278945.1.
NP_060962.2. NM_018492.3.
XP_006716431.1. XM_006716368.1.
UniGeneiHs.104741.

Genome annotation databases

EnsembliENST00000301905; ENSP00000301905; ENSG00000168078.
ENST00000522944; ENSP00000428489; ENSG00000168078.
GeneIDi55872.
KEGGihsa:55872.
UCSCiuc003xgi.3. human. [Q96KB5-1]

Polymorphism databases

DMDMi83305809.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB027249 mRNA. Translation: BAA99576.1 .
AB027250 mRNA. Translation: BAA99577.1 .
AF189722 mRNA. Translation: AAF69107.1 .
AF237709 mRNA. Translation: AAF71521.1 .
AK027291 mRNA. Translation: BAB55019.1 .
AK301836 mRNA. Translation: BAG63280.1 .
AC104997 Genomic DNA. No translation available.
CH471080 Genomic DNA. Translation: EAW63536.1 .
CH471080 Genomic DNA. Translation: EAW63537.1 .
BC015191 mRNA. Translation: AAH15191.1 .
CCDSi CCDS6063.1. [Q96KB5-1 ]
RefSeqi NP_001265874.1. NM_001278945.1.
NP_060962.2. NM_018492.3.
XP_006716431.1. XM_006716368.1.
UniGenei Hs.104741.

3D structure databases

ProteinModelPortali Q96KB5.
SMRi Q96KB5. Positions 34-316.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 120971. 14 interactions.
IntActi Q96KB5. 9 interactions.
MINTi MINT-130347.
STRINGi 9606.ENSP00000301905.

Chemistry

BindingDBi Q96KB5.
ChEMBLi CHEMBL4896.
GuidetoPHARMACOLOGYi 2140.

PTM databases

PhosphoSitei Q96KB5.

Polymorphism databases

DMDMi 83305809.

Proteomic databases

MaxQBi Q96KB5.
PaxDbi Q96KB5.
PeptideAtlasi Q96KB5.
PRIDEi Q96KB5.

Protocols and materials databases

DNASUi 55872.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000301905 ; ENSP00000301905 ; ENSG00000168078 .
ENST00000522944 ; ENSP00000428489 ; ENSG00000168078 .
GeneIDi 55872.
KEGGi hsa:55872.
UCSCi uc003xgi.3. human. [Q96KB5-1 ]

Organism-specific databases

CTDi 55872.
GeneCardsi GC08M027724.
HGNCi HGNC:18282. PBK.
HPAi HPA005753.
MIMi 611210. gene.
neXtProti NX_Q96KB5.
PharmGKBi PA134925802.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0515.
HOGENOMi HOG000294208.
HOVERGENi HBG056011.
InParanoidi Q96KB5.
KOi K08865.
OrthoDBi EOG7S4X6F.
PhylomeDBi Q96KB5.
TreeFami TF329763.

Enzyme and pathway databases

SignaLinki Q96KB5.

Miscellaneous databases

ChiTaRSi PBK. human.
GeneWikii PBK_(gene).
GenomeRNAii 55872.
NextBioi 35475910.
PROi Q96KB5.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q96KB5.
Bgeei Q96KB5.
CleanExi HS_PBK.
Genevestigatori Q96KB5.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view ]
Pfami PF00069. Pkinase. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and expression of a novel MAPKK-like protein kinase, lymphokine-activated killer T-cell-originated protein kinase, specifically expressed in the testis and activated lymphoid cells."
    Abe Y., Matsumoto S., Kito K., Ueda N.
    J. Biol. Chem. 275:21525-21531(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, PHOSPHORYLATION, TISSUE SPECIFICITY.
    Tissue: Lymphoid tissue.
  2. "Characterization of PDZ-binding kinase, a mitotic kinase."
    Gaudet S., Branton D., Lue R.A.
    Proc. Natl. Acad. Sci. U.S.A. 97:5167-5172(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), PHOSPHORYLATION, MUTAGENESIS OF 64-LEU-LEU-65; THR-320 AND VAL-322, INTERACTION WITH DLG1, VARIANT SER-107.
  3. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, VARIANT SER-107.
    Tissue: Fetal brain.
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT SER-107.
    Tissue: Embryo and Testis.
  5. "DNA sequence and analysis of human chromosome 8."
    Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T.
    , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S.
    Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  8. "Attenuation of DNA damage checkpoint by PBK, a novel mitotic kinase, involves protein-protein interaction with tumor suppressor p53."
    Nandi A.K., Ford T., Fleksher D., Neuman B., Rapoport A.P.
    Biochem. Biophys. Res. Commun. 358:181-188(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH TP53, MUTAGENESIS OF THR-9.
  9. "Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra."
    Yu L.R., Zhu Z., Chan K.C., Issaq H.J., Dimitrov D.S., Veenstra T.D.
    J. Proteome Res. 6:4150-4162(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  10. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-24; SER-32 AND SER-59, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  11. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  12. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-9; SER-32 AND SER-59, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  13. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  14. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
    Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., Giglione C.
    Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  15. "Patterns of somatic mutation in human cancer genomes."
    Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G.
    , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.
    Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS [LARGE SCALE ANALYSIS] SER-107 AND LEU-241.

Entry informationi

Entry nameiTOPK_HUMAN
AccessioniPrimary (citable) accession number: Q96KB5
Secondary accession number(s): B4DX68
, D3DST2, Q9NPD9, Q9NYL7, Q9NZK6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: December 6, 2005
Last modified: September 3, 2014
This is version 116 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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