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Q96KA5

- CLP1L_HUMAN

UniProt

Q96KA5 - CLP1L_HUMAN

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Protein

Cleft lip and palate transmembrane protein 1-like protein

Gene

CLPTM1L

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Enhances cisplatin-mediated apoptosis, when overexpressed.1 Publication

GO - Biological processi

  1. apoptotic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Apoptosis

Names & Taxonomyi

Protein namesi
Recommended name:
Cleft lip and palate transmembrane protein 1-like protein
Short name:
CLPTM1-like protein
Alternative name(s):
Cisplatin resistance-related protein 9
Short name:
CRR9p
Gene namesi
Name:CLPTM1L
Synonyms:CRR9
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 5

Organism-specific databases

HGNCiHGNC:24308. CLPTM1L.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA147358156.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 538538Cleft lip and palate transmembrane protein 1-like proteinPRO_0000331300Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi91 – 911N-linked (GlcNAc...)Sequence Analysis
Glycosylationi101 – 1011N-linked (GlcNAc...)Sequence Analysis
Glycosylationi229 – 2291N-linked (GlcNAc...)1 Publication

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ96KA5.
PaxDbiQ96KA5.
PRIDEiQ96KA5.

PTM databases

PhosphoSiteiQ96KA5.

Expressioni

Inductioni

Up-regulated by cisplatin.1 Publication

Gene expression databases

BgeeiQ96KA5.
CleanExiHS_CLPTM1L.
ExpressionAtlasiQ96KA5. baseline and differential.
GenevestigatoriQ96KA5.

Organism-specific databases

HPAiHPA014791.

Interactioni

Protein-protein interaction databases

BioGridi123354. 9 interactions.
IntActiQ96KA5. 4 interactions.
MINTiMINT-3054993.
STRINGi9606.ENSP00000313854.

Structurei

3D structure databases

ProteinModelPortaliQ96KA5.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1010CytoplasmicSequence Analysis
Topological domaini32 – 284253ExtracellularSequence AnalysisAdd
BLAST
Topological domaini306 – 32419CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini343 – 3464ExtracellularSequence Analysis
Topological domaini365 – 40238CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini424 – 4285ExtracellularSequence Analysis
Topological domaini450 – 53889CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei11 – 3121HelicalSequence AnalysisAdd
BLAST
Transmembranei285 – 30521HelicalSequence AnalysisAdd
BLAST
Transmembranei325 – 34218HelicalSequence AnalysisAdd
BLAST
Transmembranei347 – 36418HelicalSequence AnalysisAdd
BLAST
Transmembranei403 – 42321HelicalSequence AnalysisAdd
BLAST
Transmembranei429 – 44921HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the CLPTM1 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG287859.
GeneTreeiENSGT00530000063461.
HOGENOMiHOG000201405.
HOVERGENiHBG057146.
InParanoidiQ96KA5.
OMAiFQFGTYS.
OrthoDBiEOG74N5GH.
PhylomeDBiQ96KA5.
TreeFamiTF318501.

Family and domain databases

InterProiIPR008429. CLPTM1.
[Graphical view]
PANTHERiPTHR21347. PTHR21347. 1 hit.
PfamiPF05602. CLPTM1. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q96KA5-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MWSGRSSFTS LVVGVFVVYV VHTCWVMYGI VYTRPCSGDA NCIQPYLARR
60 70 80 90 100
PKLQLSVYTT TRSHLGAENN IDLVLNVEDF DVESKFERTV NVSVPKKTRN
110 120 130 140 150
NGTLYAYIFL HHAGVLPWHD GKQVHLVSPL TTYMVPKPEE INLLTGESDT
160 170 180 190 200
QQIEAEKKPT SALDEPVSHW RPRLALNVMA DNFVFDGSSL PADVHRYMKM
210 220 230 240 250
IQLGKTVHYL PILFIDQLSN RVKDLMVINR STTELPLTVS YDKVSLGRLR
260 270 280 290 300
FWIHMQDAVY SLQQFGFSEK DADEVKGIFV DTNLYFLALT FFVAAFHLLF
310 320 330 340 350
DFLAFKNDIS FWKKKKSMIG MSTKAVLWRC FSTVVIFLFL LDEQTSLLVL
360 370 380 390 400
VPAGVGAAIE LWKVKKALKM TIFWRGLMPE FQFGTYSESE RKTEEYDTQA
410 420 430 440 450
MKYLSYLLYP LCVGGAVYSL LNIKYKSWYS WLINSFVNGV YAFGFLFMLP
460 470 480 490 500
QLFVNYKLKS VAHLPWKAFT YKAFNTFIDD VFAFIITMPT SHRLACFRDD
510 520 530
VVFLVYLYQR WLYPVDKRRV NEFGESYEEK ATRAPHTD
Length:538
Mass (Da):62,229
Last modified:December 1, 2001 - v1
Checksum:iA83FF068AED01FC7
GO
Isoform 2 (identifier: Q96KA5-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     325-360: Missing.

Show »
Length:502
Mass (Da):58,356
Checksum:iF336609A093D72AB
GO

Sequence cautioni

The sequence BAB20083.1 differs from that shown. Reason: Erroneous initiation.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti313 – 3131K → N in a breast cancer sample; somatic mutation. 1 Publication
VAR_042754
Natural varianti537 – 5371T → M.
Corresponds to variant rs33955038 [ dbSNP | Ensembl ].
VAR_042755

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei325 – 36036Missing in isoform 2. 1 PublicationVSP_033157Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK027306 mRNA. Translation: BAB55030.1.
CH471102 Genomic DNA. Translation: EAX08162.1.
CH471102 Genomic DNA. Translation: EAX08163.1.
BC016399 mRNA. Translation: AAH16399.1.
BC025305 mRNA. Translation: AAH25305.1.
AB045223 mRNA. Translation: BAB20083.1. Different initiation.
AL832953 mRNA. Translation: CAH56333.1.
CCDSiCCDS3862.1. [Q96KA5-1]
PIRiJC7599.
RefSeqiNP_110409.2. NM_030782.3. [Q96KA5-1]
UniGeneiHs.444673.

Genome annotation databases

EnsembliENST00000320895; ENSP00000313854; ENSG00000049656. [Q96KA5-1]
GeneIDi81037.
KEGGihsa:81037.
UCSCiuc003jch.3. human. [Q96KA5-1]

Polymorphism databases

DMDMi74732209.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK027306 mRNA. Translation: BAB55030.1 .
CH471102 Genomic DNA. Translation: EAX08162.1 .
CH471102 Genomic DNA. Translation: EAX08163.1 .
BC016399 mRNA. Translation: AAH16399.1 .
BC025305 mRNA. Translation: AAH25305.1 .
AB045223 mRNA. Translation: BAB20083.1 . Different initiation.
AL832953 mRNA. Translation: CAH56333.1 .
CCDSi CCDS3862.1. [Q96KA5-1 ]
PIRi JC7599.
RefSeqi NP_110409.2. NM_030782.3. [Q96KA5-1 ]
UniGenei Hs.444673.

3D structure databases

ProteinModelPortali Q96KA5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 123354. 9 interactions.
IntActi Q96KA5. 4 interactions.
MINTi MINT-3054993.
STRINGi 9606.ENSP00000313854.

PTM databases

PhosphoSitei Q96KA5.

Polymorphism databases

DMDMi 74732209.

Proteomic databases

MaxQBi Q96KA5.
PaxDbi Q96KA5.
PRIDEi Q96KA5.

Protocols and materials databases

DNASUi 81037.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000320895 ; ENSP00000313854 ; ENSG00000049656 . [Q96KA5-1 ]
GeneIDi 81037.
KEGGi hsa:81037.
UCSCi uc003jch.3. human. [Q96KA5-1 ]

Organism-specific databases

CTDi 81037.
GeneCardsi GC05M001317.
HGNCi HGNC:24308. CLPTM1L.
HPAi HPA014791.
MIMi 612585. gene.
neXtProti NX_Q96KA5.
PharmGKBi PA147358156.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG287859.
GeneTreei ENSGT00530000063461.
HOGENOMi HOG000201405.
HOVERGENi HBG057146.
InParanoidi Q96KA5.
OMAi FQFGTYS.
OrthoDBi EOG74N5GH.
PhylomeDBi Q96KA5.
TreeFami TF318501.

Miscellaneous databases

ChiTaRSi CLPTM1L. human.
GeneWikii CLPTM1L.
GenomeRNAii 81037.
NextBioi 71380.
PROi Q96KA5.
SOURCEi Search...

Gene expression databases

Bgeei Q96KA5.
CleanExi HS_CLPTM1L.
ExpressionAtlasi Q96KA5. baseline and differential.
Genevestigatori Q96KA5.

Family and domain databases

InterProi IPR008429. CLPTM1.
[Graphical view ]
PANTHERi PTHR21347. PTHR21347. 1 hit.
Pfami PF05602. CLPTM1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Embryo.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 130-538 (ISOFORM 2).
    Tissue: Colon and Ovary.
  4. "A novel gene, CRR9, which was up-regulated in CDDP-resistant ovarian tumor cell line, was associated with apoptosis."
    Yamamoto K., Okamoto A., Isonishi S., Ochiai K., Ohtake Y.
    Biochem. Biophys. Res. Commun. 280:1148-1154(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 6-538 (ISOFORM 1), FUNCTION, INDUCTION.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 391-538 (ISOFORM 1).
    Tissue: Stomach.
  6. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
    Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
    J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-229.
    Tissue: Liver.
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. Cited for: VARIANT [LARGE SCALE ANALYSIS] ASN-313.

Entry informationi

Entry nameiCLP1L_HUMAN
AccessioniPrimary (citable) accession number: Q96KA5
Secondary accession number(s): D3DTC1
, Q658W6, Q7LG29, Q96AZ0, Q9H3N4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: December 1, 2001
Last modified: October 29, 2014
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3