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Q96KA5 (CLP1L_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 99. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cleft lip and palate transmembrane protein 1-like protein

Short name=CLPTM1-like protein
Alternative name(s):
Cisplatin resistance-related protein 9
Short name=CRR9p
Gene names
Name:CLPTM1L
Synonyms:CRR9
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length538 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Enhances cisplatin-mediated apoptosis, when overexpressed. Ref.4

Subcellular location

Membrane; Multi-pass membrane protein Potential.

Induction

Up-regulated by cisplatin. Ref.4

Sequence similarities

Belongs to the CLPTM1 family.

Sequence caution

The sequence BAB20083.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Biological processApoptosis
   Cellular componentMembrane
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainTransmembrane
Transmembrane helix
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processapoptotic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q96KA5-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q96KA5-2)

The sequence of this isoform differs from the canonical sequence as follows:
     325-360: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 538538Cleft lip and palate transmembrane protein 1-like protein
PRO_0000331300

Regions

Topological domain1 – 1010Cytoplasmic Potential
Transmembrane11 – 3121Helical; Potential
Topological domain32 – 284253Extracellular Potential
Transmembrane285 – 30521Helical; Potential
Topological domain306 – 32419Cytoplasmic Potential
Transmembrane325 – 34218Helical; Potential
Topological domain343 – 3464Extracellular Potential
Transmembrane347 – 36418Helical; Potential
Topological domain365 – 40238Cytoplasmic Potential
Transmembrane403 – 42321Helical; Potential
Topological domain424 – 4285Extracellular Potential
Transmembrane429 – 44921Helical; Potential
Topological domain450 – 53889Cytoplasmic Potential

Amino acid modifications

Glycosylation911N-linked (GlcNAc...) Potential
Glycosylation1011N-linked (GlcNAc...) Potential
Glycosylation2291N-linked (GlcNAc...) Ref.6

Natural variations

Alternative sequence325 – 36036Missing in isoform 2.
VSP_033157
Natural variant3131K → N in a breast cancer sample; somatic mutation. Ref.8
VAR_042754
Natural variant5371T → M.
Corresponds to variant rs33955038 [ dbSNP | Ensembl ].
VAR_042755

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: A83FF068AED01FC7

FASTA53862,229
        10         20         30         40         50         60 
MWSGRSSFTS LVVGVFVVYV VHTCWVMYGI VYTRPCSGDA NCIQPYLARR PKLQLSVYTT 

        70         80         90        100        110        120 
TRSHLGAENN IDLVLNVEDF DVESKFERTV NVSVPKKTRN NGTLYAYIFL HHAGVLPWHD 

       130        140        150        160        170        180 
GKQVHLVSPL TTYMVPKPEE INLLTGESDT QQIEAEKKPT SALDEPVSHW RPRLALNVMA 

       190        200        210        220        230        240 
DNFVFDGSSL PADVHRYMKM IQLGKTVHYL PILFIDQLSN RVKDLMVINR STTELPLTVS 

       250        260        270        280        290        300 
YDKVSLGRLR FWIHMQDAVY SLQQFGFSEK DADEVKGIFV DTNLYFLALT FFVAAFHLLF 

       310        320        330        340        350        360 
DFLAFKNDIS FWKKKKSMIG MSTKAVLWRC FSTVVIFLFL LDEQTSLLVL VPAGVGAAIE 

       370        380        390        400        410        420 
LWKVKKALKM TIFWRGLMPE FQFGTYSESE RKTEEYDTQA MKYLSYLLYP LCVGGAVYSL 

       430        440        450        460        470        480 
LNIKYKSWYS WLINSFVNGV YAFGFLFMLP QLFVNYKLKS VAHLPWKAFT YKAFNTFIDD 

       490        500        510        520        530 
VFAFIITMPT SHRLACFRDD VVFLVYLYQR WLYPVDKRRV NEFGESYEEK ATRAPHTD 

« Hide

Isoform 2 [UniParc].

Checksum: F336609A093D72AB
Show »

FASTA50258,356

References

« Hide 'large scale' references
[1]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Embryo.
[2]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 130-538 (ISOFORM 2).
Tissue: Colon and Ovary.
[4]"A novel gene, CRR9, which was up-regulated in CDDP-resistant ovarian tumor cell line, was associated with apoptosis."
Yamamoto K., Okamoto A., Isonishi S., Ochiai K., Ohtake Y.
Biochem. Biophys. Res. Commun. 280:1148-1154(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 6-538 (ISOFORM 1), FUNCTION, INDUCTION.
[5]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 391-538 (ISOFORM 1).
Tissue: Stomach.
[6]"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-229.
Tissue: Liver.
[7]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[8]"The consensus coding sequences of human breast and colorectal cancers."
Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. expand/collapse author list , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E.
Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT [LARGE SCALE ANALYSIS] ASN-313.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK027306 mRNA. Translation: BAB55030.1.
CH471102 Genomic DNA. Translation: EAX08162.1.
CH471102 Genomic DNA. Translation: EAX08163.1.
BC016399 mRNA. Translation: AAH16399.1.
BC025305 mRNA. Translation: AAH25305.1.
AB045223 mRNA. Translation: BAB20083.1. Different initiation.
AL832953 mRNA. Translation: CAH56333.1.
CCDSCCDS3862.1. [Q96KA5-1]
PIRJC7599.
RefSeqNP_110409.2. NM_030782.3. [Q96KA5-1]
UniGeneHs.444673.

3D structure databases

ProteinModelPortalQ96KA5.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid123354. 9 interactions.
IntActQ96KA5. 4 interactions.
MINTMINT-3054993.
STRING9606.ENSP00000313854.

PTM databases

PhosphoSiteQ96KA5.

Polymorphism databases

DMDM74732209.

Proteomic databases

MaxQBQ96KA5.
PaxDbQ96KA5.
PRIDEQ96KA5.

Protocols and materials databases

DNASU81037.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000320895; ENSP00000313854; ENSG00000049656. [Q96KA5-1]
ENST00000320927; ENSP00000315196; ENSG00000049656. [Q96KA5-2]
GeneID81037.
KEGGhsa:81037.
UCSCuc003jch.3. human. [Q96KA5-1]

Organism-specific databases

CTD81037.
GeneCardsGC05M001317.
HGNCHGNC:24308. CLPTM1L.
HPAHPA014791.
MIM612585. gene.
neXtProtNX_Q96KA5.
PharmGKBPA147358156.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG287859.
HOGENOMHOG000201405.
HOVERGENHBG057146.
InParanoidQ96KA5.
OMAFQFGTYS.
OrthoDBEOG74N5GH.
PhylomeDBQ96KA5.
TreeFamTF318501.

Gene expression databases

ArrayExpressQ96KA5.
BgeeQ96KA5.
CleanExHS_CLPTM1L.
GenevestigatorQ96KA5.

Family and domain databases

InterProIPR008429. CLPTM1.
[Graphical view]
PANTHERPTHR21347. PTHR21347. 1 hit.
PfamPF05602. CLPTM1. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSCLPTM1L. human.
GeneWikiCLPTM1L.
GenomeRNAi81037.
NextBio71380.
PROQ96KA5.
SOURCESearch...

Entry information

Entry nameCLP1L_HUMAN
AccessionPrimary (citable) accession number: Q96KA5
Secondary accession number(s): D3DTC1 expand/collapse secondary AC list , Q658W6, Q7LG29, Q96AZ0, Q9H3N4
Entry history
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: December 1, 2001
Last modified: July 9, 2014
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 5

Human chromosome 5: entries, gene names and cross-references to MIM