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Protein

Cleft lip and palate transmembrane protein 1-like protein

Gene

CLPTM1L

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Enhances cisplatin-mediated apoptosis, when overexpressed.1 Publication

GO - Biological processi

  1. apoptotic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Apoptosis

Names & Taxonomyi

Protein namesi
Recommended name:
Cleft lip and palate transmembrane protein 1-like protein
Short name:
CLPTM1-like protein
Alternative name(s):
Cisplatin resistance-related protein 9
Short name:
CRR9p
Gene namesi
Name:CLPTM1L
Synonyms:CRR9
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componentsi: Chromosome 5, Unplaced

Organism-specific databases

HGNCiHGNC:24308. CLPTM1L.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1010CytoplasmicSequence Analysis
Transmembranei11 – 3121HelicalSequence AnalysisAdd
BLAST
Topological domaini32 – 284253ExtracellularSequence AnalysisAdd
BLAST
Transmembranei285 – 30521HelicalSequence AnalysisAdd
BLAST
Topological domaini306 – 32419CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei325 – 34218HelicalSequence AnalysisAdd
BLAST
Topological domaini343 – 3464ExtracellularSequence Analysis
Transmembranei347 – 36418HelicalSequence AnalysisAdd
BLAST
Topological domaini365 – 40238CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei403 – 42321HelicalSequence AnalysisAdd
BLAST
Topological domaini424 – 4285ExtracellularSequence Analysis
Transmembranei429 – 44921HelicalSequence AnalysisAdd
BLAST
Topological domaini450 – 53889CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA147358156.

Polymorphism and mutation databases

BioMutaiCLPTM1L.
DMDMi74732209.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 538538Cleft lip and palate transmembrane protein 1-like proteinPRO_0000331300Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi91 – 911N-linked (GlcNAc...)Sequence Analysis
Glycosylationi101 – 1011N-linked (GlcNAc...)Sequence Analysis
Glycosylationi229 – 2291N-linked (GlcNAc...)1 Publication

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ96KA5.
PaxDbiQ96KA5.
PRIDEiQ96KA5.

PTM databases

PhosphoSiteiQ96KA5.

Expressioni

Inductioni

Up-regulated by cisplatin.1 Publication

Gene expression databases

BgeeiQ96KA5.
CleanExiHS_CLPTM1L.
ExpressionAtlasiQ96KA5. baseline and differential.
GenevestigatoriQ96KA5.

Organism-specific databases

HPAiHPA014791.

Interactioni

Protein-protein interaction databases

BioGridi123354. 9 interactions.
IntActiQ96KA5. 4 interactions.
MINTiMINT-3054993.
STRINGi9606.ENSP00000313854.

Structurei

3D structure databases

ProteinModelPortaliQ96KA5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CLPTM1 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG287859.
GeneTreeiENSGT00530000063461.
HOGENOMiHOG000201405.
HOVERGENiHBG057146.
InParanoidiQ96KA5.
OMAiFQFGTYS.
OrthoDBiEOG74N5GH.
PhylomeDBiQ96KA5.
TreeFamiTF318501.

Family and domain databases

InterProiIPR008429. CLPTM1.
IPR030434. CLPTM1L.
[Graphical view]
PANTHERiPTHR21347. PTHR21347. 1 hit.
PTHR21347:SF1. PTHR21347:SF1. 1 hit.
PfamiPF05602. CLPTM1. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96KA5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MWSGRSSFTS LVVGVFVVYV VHTCWVMYGI VYTRPCSGDA NCIQPYLARR
60 70 80 90 100
PKLQLSVYTT TRSHLGAENN IDLVLNVEDF DVESKFERTV NVSVPKKTRN
110 120 130 140 150
NGTLYAYIFL HHAGVLPWHD GKQVHLVSPL TTYMVPKPEE INLLTGESDT
160 170 180 190 200
QQIEAEKKPT SALDEPVSHW RPRLALNVMA DNFVFDGSSL PADVHRYMKM
210 220 230 240 250
IQLGKTVHYL PILFIDQLSN RVKDLMVINR STTELPLTVS YDKVSLGRLR
260 270 280 290 300
FWIHMQDAVY SLQQFGFSEK DADEVKGIFV DTNLYFLALT FFVAAFHLLF
310 320 330 340 350
DFLAFKNDIS FWKKKKSMIG MSTKAVLWRC FSTVVIFLFL LDEQTSLLVL
360 370 380 390 400
VPAGVGAAIE LWKVKKALKM TIFWRGLMPE FQFGTYSESE RKTEEYDTQA
410 420 430 440 450
MKYLSYLLYP LCVGGAVYSL LNIKYKSWYS WLINSFVNGV YAFGFLFMLP
460 470 480 490 500
QLFVNYKLKS VAHLPWKAFT YKAFNTFIDD VFAFIITMPT SHRLACFRDD
510 520 530
VVFLVYLYQR WLYPVDKRRV NEFGESYEEK ATRAPHTD
Length:538
Mass (Da):62,229
Last modified:December 1, 2001 - v1
Checksum:iA83FF068AED01FC7
GO
Isoform 2 (identifier: Q96KA5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     325-360: Missing.

Show »
Length:502
Mass (Da):58,356
Checksum:iF336609A093D72AB
GO

Sequence cautioni

The sequence BAB20083.1 differs from that shown. Reason: Erroneous initiation. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti313 – 3131K → N in a breast cancer sample; somatic mutation. 1 Publication
VAR_042754
Natural varianti537 – 5371T → M.
Corresponds to variant rs33955038 [ dbSNP | Ensembl ].
VAR_042755

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei325 – 36036Missing in isoform 2. 1 PublicationVSP_033157Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK027306 mRNA. Translation: BAB55030.1.
CH471102 Genomic DNA. Translation: EAX08162.1.
CH471102 Genomic DNA. Translation: EAX08163.1.
BC016399 mRNA. Translation: AAH16399.1.
BC025305 mRNA. Translation: AAH25305.1.
AB045223 mRNA. Translation: BAB20083.1. Different initiation.
AL832953 mRNA. Translation: CAH56333.1.
CCDSiCCDS3862.1. [Q96KA5-1]
PIRiJC7599.
RefSeqiNP_110409.2. NM_030782.3. [Q96KA5-1]
UniGeneiHs.444673.

Genome annotation databases

EnsembliENST00000320895; ENSP00000313854; ENSG00000049656. [Q96KA5-1]
ENST00000620010; ENSP00000480372; ENSG00000274811. [Q96KA5-1]
GeneIDi81037.
KEGGihsa:81037.
UCSCiuc003jch.3. human. [Q96KA5-1]

Polymorphism and mutation databases

BioMutaiCLPTM1L.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK027306 mRNA. Translation: BAB55030.1.
CH471102 Genomic DNA. Translation: EAX08162.1.
CH471102 Genomic DNA. Translation: EAX08163.1.
BC016399 mRNA. Translation: AAH16399.1.
BC025305 mRNA. Translation: AAH25305.1.
AB045223 mRNA. Translation: BAB20083.1. Different initiation.
AL832953 mRNA. Translation: CAH56333.1.
CCDSiCCDS3862.1. [Q96KA5-1]
PIRiJC7599.
RefSeqiNP_110409.2. NM_030782.3. [Q96KA5-1]
UniGeneiHs.444673.

3D structure databases

ProteinModelPortaliQ96KA5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123354. 9 interactions.
IntActiQ96KA5. 4 interactions.
MINTiMINT-3054993.
STRINGi9606.ENSP00000313854.

PTM databases

PhosphoSiteiQ96KA5.

Polymorphism and mutation databases

BioMutaiCLPTM1L.
DMDMi74732209.

Proteomic databases

MaxQBiQ96KA5.
PaxDbiQ96KA5.
PRIDEiQ96KA5.

Protocols and materials databases

DNASUi81037.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000320895; ENSP00000313854; ENSG00000049656. [Q96KA5-1]
ENST00000620010; ENSP00000480372; ENSG00000274811. [Q96KA5-1]
GeneIDi81037.
KEGGihsa:81037.
UCSCiuc003jch.3. human. [Q96KA5-1]

Organism-specific databases

CTDi81037.
GeneCardsiGC05M001317.
HGNCiHGNC:24308. CLPTM1L.
HPAiHPA014791.
MIMi612585. gene.
neXtProtiNX_Q96KA5.
PharmGKBiPA147358156.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG287859.
GeneTreeiENSGT00530000063461.
HOGENOMiHOG000201405.
HOVERGENiHBG057146.
InParanoidiQ96KA5.
OMAiFQFGTYS.
OrthoDBiEOG74N5GH.
PhylomeDBiQ96KA5.
TreeFamiTF318501.

Miscellaneous databases

ChiTaRSiCLPTM1L. human.
GeneWikiiCLPTM1L.
GenomeRNAii81037.
NextBioi71380.
PROiQ96KA5.
SOURCEiSearch...

Gene expression databases

BgeeiQ96KA5.
CleanExiHS_CLPTM1L.
ExpressionAtlasiQ96KA5. baseline and differential.
GenevestigatoriQ96KA5.

Family and domain databases

InterProiIPR008429. CLPTM1.
IPR030434. CLPTM1L.
[Graphical view]
PANTHERiPTHR21347. PTHR21347. 1 hit.
PTHR21347:SF1. PTHR21347:SF1. 1 hit.
PfamiPF05602. CLPTM1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Embryo.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 130-538 (ISOFORM 2).
    Tissue: Colon and Ovary.
  4. "A novel gene, CRR9, which was up-regulated in CDDP-resistant ovarian tumor cell line, was associated with apoptosis."
    Yamamoto K., Okamoto A., Isonishi S., Ochiai K., Ohtake Y.
    Biochem. Biophys. Res. Commun. 280:1148-1154(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 6-538 (ISOFORM 1), FUNCTION, INDUCTION.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 391-538 (ISOFORM 1).
    Tissue: Stomach.
  6. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
    Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
    J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-229.
    Tissue: Liver.
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. Cited for: VARIANT [LARGE SCALE ANALYSIS] ASN-313.

Entry informationi

Entry nameiCLP1L_HUMAN
AccessioniPrimary (citable) accession number: Q96KA5
Secondary accession number(s): D3DTC1
, Q658W6, Q7LG29, Q96AZ0, Q9H3N4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: December 1, 2001
Last modified: April 29, 2015
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.