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Reviewed, UniProtKB/Swiss-Prot Q96KA5 (CLP1L_HUMAN)

Last modified June 16, 2009. Version 54. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Alternative products · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Cleft lip and palate transmembrane protein 1-like protein
      Short name=CLPTM1-like protein
Alternative name(s):
    Cisplatin resistance-related protein 9
    CRR9p
Gene names
Name: CLPTM1L
Synonyms: CRR9
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length538 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

General annotation (Comments)

Function

Enhances cisplatin-mediated apoptosis, when overexpressed. Ref.4

Subcellular location

Membrane; Multi-pass membrane protein Potential.

Induction

Up-regulated by cisplatin. Ref.4

Sequence similarities

Belongs to the CLPTM1 family.

Ontologies

Keywords
   Biological processApoptosis
   Cellular componentMembrane
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainTransmembrane
   PTMGlycoprotein
Gene Ontology (GO)
   Biological processapoptosis

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentintegral to membrane

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q96KA5-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q96KA5-2)

The sequence of this isoform differs from the canonical sequence as follows:
     325-360: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 538538Cleft lip and palate transmembrane protein 1-like protein
PRO_0000331300

Regions

Topological domain1 – 1010Cytoplasmic Potential
Transmembrane11 – 3121 Potential
Topological domain32 – 284253Extracellular Potential
Transmembrane285 – 30521 Potential
Topological domain306 – 32419Cytoplasmic Potential
Transmembrane325 – 34218 Potential
Topological domain343 – 3464Extracellular Potential
Transmembrane347 – 36418 Potential
Topological domain365 – 40238Cytoplasmic Potential
Transmembrane403 – 42321 Potential
Topological domain424 – 4285Extracellular Potential
Transmembrane429 – 44921 Potential
Topological domain450 – 53889Cytoplasmic Potential

Amino acid modifications

Glycosylation911N-linked (GlcNAc...) Potential
Glycosylation1011N-linked (GlcNAc...) Potential
Glycosylation2291N-linked (GlcNAc...)

Natural variations

Alternative sequence325 – 36036Missing in isoform 2.
VSP_033157
Natural variant3131K → N in a breast cancer sample; somatic mutation. Ref.8
VAR_042754
Natural variant5371T → M: dbSNP rs33955038.
VAR_042755

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: A83FF068AED01FC7

FASTA53862,229
        10         20         30         40         50         60 
MWSGRSSFTS LVVGVFVVYV VHTCWVMYGI VYTRPCSGDA NCIQPYLARR PKLQLSVYTT 

        70         80         90        100        110        120 
TRSHLGAENN IDLVLNVEDF DVESKFERTV NVSVPKKTRN NGTLYAYIFL HHAGVLPWHD 

       130        140        150        160        170        180 
GKQVHLVSPL TTYMVPKPEE INLLTGESDT QQIEAEKKPT SALDEPVSHW RPRLALNVMA 

       190        200        210        220        230        240 
DNFVFDGSSL PADVHRYMKM IQLGKTVHYL PILFIDQLSN RVKDLMVINR STTELPLTVS 

       250        260        270        280        290        300 
YDKVSLGRLR FWIHMQDAVY SLQQFGFSEK DADEVKGIFV DTNLYFLALT FFVAAFHLLF 

       310        320        330        340        350        360 
DFLAFKNDIS FWKKKKSMIG MSTKAVLWRC FSTVVIFLFL LDEQTSLLVL VPAGVGAAIE 

       370        380        390        400        410        420 
LWKVKKALKM TIFWRGLMPE FQFGTYSESE RKTEEYDTQA MKYLSYLLYP LCVGGAVYSL 

       430        440        450        460        470        480 
LNIKYKSWYS WLINSFVNGV YAFGFLFMLP QLFVNYKLKS VAHLPWKAFT YKAFNTFIDD 

       490        500        510        520        530 
VFAFIITMPT SHRLACFRDD VVFLVYLYQR WLYPVDKRRV NEFGESYEEK ATRAPHTD 

« Hide

Isoform 2.

Checksum: F336609A093D72AB
Show »

FASTA50258,356

References

[1]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Embryo.
[2]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 130-538 (ISOFORM 2).
Tissue: Colon and Ovary.
[4]"A novel gene, CRR9, which was up-regulated in CDDP-resistant ovarian tumor cell line, was associated with apoptosis."
Yamamoto K., Okamoto A., Isonishi S., Ochiai K., Ohtake Y.
Biochem. Biophys. Res. Commun. 280:1148-1154(2001) [PubMed: 11162647] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 6-538 (ISOFORM 1), FUNCTION, INDUCTION.
[5]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Blocker H., Heubner D., Hoerlein A., Michel G., Wedler H., Kohrer K., Ottenwalder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed: 17974005] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 391-538 (ISOFORM 1).
Tissue: Stomach.
[6]Colinge J., Superti-Furga G., Bennett K.L.
Submitted (OCT-2008) to UniProtKB
Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY.
[7]"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
J. Proteome Res. 8:651-661(2009) [PubMed: 19159218] [Abstract]
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-229, MASS SPECTROMETRY.
Tissue: Liver.
[8]"The consensus coding sequences of human breast and colorectal cancers."
Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. expand/collapse author list , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E.
Science 314:268-274(2006) [PubMed: 16959974] [Abstract]
Cited for: VARIANT [LARGE SCALE ANALYSIS] ASN-313.

Cross-references

Sequence databases

AK027306 mRNA. Translation: BAB55030.1.
CH471102 Genomic DNA. Translation: EAX08162.1.
BC016399 mRNA. Translation: AAH16399.1.
BC025305 mRNA. Translation: AAH25305.1.
AB045223 mRNA. Translation: BAB20083.1. Different initiation.
AL832953 mRNA. Translation: CAH56333.1.
IPIIPI00151358.
IPI00186429.
PIRJC7599.
RefSeqNP_110409.2.
UniGeneHs.444673

3D structure databases

ModBaseSearch...

Proteomic databases

PRIDEQ96KA5.

Genome annotation databases

EnsemblENSG00000049656. Homo sapiens. [Contig view]
GeneID81037.
KEGGhsa:81037.

Organism-specific databases

GeneCardsGC05M001371.
HGNCHGNC:24308. CLPTM1L.
HPAHPA014791.
GenAtlasSearch...

Phylogenomic databases

HOGENOMQ96KA5.
HOVERGENQ96KA5.
OMAQ96KA5. HRYMKMI.

Gene expression databases

ArrayExpressQ96KA5.
BgeeQ96KA5.
CleanExHS_CLPTM1L.

Family and domain databases

InterProIPR008429. CLPTM1.
[Graphical view]
PANTHERPTHR21347. CLPTM1. 1 hit.
PfamPF05602. CLPTM1. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio71380.

Entry information

Entry nameCLP1L_HUMAN
AccessionPrimary (citable) accession number: Q96KA5
Secondary accession number(s): Q658W6 expand/collapse secondary AC list , Q7LG29, Q96AZ0, Q9H3N4
Entry history
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: December 1, 2001
Last modified: June 16, 2009
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Relevant documents

Human chromosome 5

Human chromosome 5: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Alternative products · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents