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Protein

Cleft lip and palate transmembrane protein 1-like protein

Gene

CLPTM1L

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Enhances cisplatin-mediated apoptosis, when overexpressed.1 Publication

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Apoptosis

Names & Taxonomyi

Protein namesi
Recommended name:
Cleft lip and palate transmembrane protein 1-like protein
Short name:
CLPTM1-like protein
Alternative name(s):
Cisplatin resistance-related protein 9
Short name:
CRR9p
Gene namesi
Name:CLPTM1L
Synonyms:CRR9
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:24308. CLPTM1L.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 10CytoplasmicSequence analysis10
Transmembranei11 – 31HelicalSequence analysisAdd BLAST21
Topological domaini32 – 284ExtracellularSequence analysisAdd BLAST253
Transmembranei285 – 305HelicalSequence analysisAdd BLAST21
Topological domaini306 – 324CytoplasmicSequence analysisAdd BLAST19
Transmembranei325 – 342HelicalSequence analysisAdd BLAST18
Topological domaini343 – 346ExtracellularSequence analysis4
Transmembranei347 – 364HelicalSequence analysisAdd BLAST18
Topological domaini365 – 402CytoplasmicSequence analysisAdd BLAST38
Transmembranei403 – 423HelicalSequence analysisAdd BLAST21
Topological domaini424 – 428ExtracellularSequence analysis5
Transmembranei429 – 449HelicalSequence analysisAdd BLAST21
Topological domaini450 – 538CytoplasmicSequence analysisAdd BLAST89

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi81037.
OpenTargetsiENSG00000049656.
ENSG00000274811.
PharmGKBiPA147358156.

Polymorphism and mutation databases

BioMutaiCLPTM1L.
DMDMi74732209.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003313001 – 538Cleft lip and palate transmembrane protein 1-like proteinAdd BLAST538

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi91N-linked (GlcNAc...)Sequence analysis1
Glycosylationi101N-linked (GlcNAc...)Sequence analysis1
Glycosylationi229N-linked (GlcNAc...)1 Publication1

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ96KA5.
MaxQBiQ96KA5.
PaxDbiQ96KA5.
PeptideAtlasiQ96KA5.
PRIDEiQ96KA5.

PTM databases

iPTMnetiQ96KA5.
PhosphoSitePlusiQ96KA5.
SwissPalmiQ96KA5.

Expressioni

Inductioni

Up-regulated by cisplatin.1 Publication

Gene expression databases

BgeeiENSG00000049656.
CleanExiHS_CLPTM1L.
ExpressionAtlasiQ96KA5. baseline and differential.
GenevisibleiQ96KA5. HS.

Organism-specific databases

HPAiHPA014791.

Interactioni

Protein-protein interaction databases

BioGridi123354. 23 interactors.
IntActiQ96KA5. 18 interactors.
MINTiMINT-3054993.
STRINGi9606.ENSP00000313854.

Structurei

3D structure databases

ProteinModelPortaliQ96KA5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CLPTM1 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2489. Eukaryota.
ENOG410XPEV. LUCA.
GeneTreeiENSGT00530000063461.
HOGENOMiHOG000201405.
HOVERGENiHBG057146.
InParanoidiQ96KA5.
OMAiFQFGTYS.
OrthoDBiEOG091G05EF.
PhylomeDBiQ96KA5.
TreeFamiTF318501.

Family and domain databases

InterProiIPR008429. CLPTM1.
IPR030434. CLPTM1L.
[Graphical view]
PANTHERiPTHR21347. PTHR21347. 1 hit.
PTHR21347:SF1. PTHR21347:SF1. 1 hit.
PfamiPF05602. CLPTM1. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96KA5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MWSGRSSFTS LVVGVFVVYV VHTCWVMYGI VYTRPCSGDA NCIQPYLARR
60 70 80 90 100
PKLQLSVYTT TRSHLGAENN IDLVLNVEDF DVESKFERTV NVSVPKKTRN
110 120 130 140 150
NGTLYAYIFL HHAGVLPWHD GKQVHLVSPL TTYMVPKPEE INLLTGESDT
160 170 180 190 200
QQIEAEKKPT SALDEPVSHW RPRLALNVMA DNFVFDGSSL PADVHRYMKM
210 220 230 240 250
IQLGKTVHYL PILFIDQLSN RVKDLMVINR STTELPLTVS YDKVSLGRLR
260 270 280 290 300
FWIHMQDAVY SLQQFGFSEK DADEVKGIFV DTNLYFLALT FFVAAFHLLF
310 320 330 340 350
DFLAFKNDIS FWKKKKSMIG MSTKAVLWRC FSTVVIFLFL LDEQTSLLVL
360 370 380 390 400
VPAGVGAAIE LWKVKKALKM TIFWRGLMPE FQFGTYSESE RKTEEYDTQA
410 420 430 440 450
MKYLSYLLYP LCVGGAVYSL LNIKYKSWYS WLINSFVNGV YAFGFLFMLP
460 470 480 490 500
QLFVNYKLKS VAHLPWKAFT YKAFNTFIDD VFAFIITMPT SHRLACFRDD
510 520 530
VVFLVYLYQR WLYPVDKRRV NEFGESYEEK ATRAPHTD
Length:538
Mass (Da):62,229
Last modified:December 1, 2001 - v1
Checksum:iA83FF068AED01FC7
GO
Isoform 2 (identifier: Q96KA5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     325-360: Missing.

Show »
Length:502
Mass (Da):58,356
Checksum:iF336609A093D72AB
GO

Sequence cautioni

The sequence BAB20083 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_042754313K → N in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_042755537T → M.Corresponds to variant rs33955038dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_033157325 – 360Missing in isoform 2. 1 PublicationAdd BLAST36

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK027306 mRNA. Translation: BAB55030.1.
CH471102 Genomic DNA. Translation: EAX08162.1.
CH471102 Genomic DNA. Translation: EAX08163.1.
BC016399 mRNA. Translation: AAH16399.1.
BC025305 mRNA. Translation: AAH25305.1.
AB045223 mRNA. Translation: BAB20083.1. Different initiation.
AL832953 mRNA. Translation: CAH56333.1.
CCDSiCCDS3862.1. [Q96KA5-1]
PIRiJC7599.
RefSeqiNP_110409.2. NM_030782.4. [Q96KA5-1]
UniGeneiHs.444673.

Genome annotation databases

EnsembliENST00000320895; ENSP00000313854; ENSG00000049656. [Q96KA5-1]
ENST00000620010; ENSP00000480372; ENSG00000274811. [Q96KA5-1]
GeneIDi81037.
KEGGihsa:81037.
UCSCiuc003jch.4. human. [Q96KA5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK027306 mRNA. Translation: BAB55030.1.
CH471102 Genomic DNA. Translation: EAX08162.1.
CH471102 Genomic DNA. Translation: EAX08163.1.
BC016399 mRNA. Translation: AAH16399.1.
BC025305 mRNA. Translation: AAH25305.1.
AB045223 mRNA. Translation: BAB20083.1. Different initiation.
AL832953 mRNA. Translation: CAH56333.1.
CCDSiCCDS3862.1. [Q96KA5-1]
PIRiJC7599.
RefSeqiNP_110409.2. NM_030782.4. [Q96KA5-1]
UniGeneiHs.444673.

3D structure databases

ProteinModelPortaliQ96KA5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123354. 23 interactors.
IntActiQ96KA5. 18 interactors.
MINTiMINT-3054993.
STRINGi9606.ENSP00000313854.

PTM databases

iPTMnetiQ96KA5.
PhosphoSitePlusiQ96KA5.
SwissPalmiQ96KA5.

Polymorphism and mutation databases

BioMutaiCLPTM1L.
DMDMi74732209.

Proteomic databases

EPDiQ96KA5.
MaxQBiQ96KA5.
PaxDbiQ96KA5.
PeptideAtlasiQ96KA5.
PRIDEiQ96KA5.

Protocols and materials databases

DNASUi81037.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000320895; ENSP00000313854; ENSG00000049656. [Q96KA5-1]
ENST00000620010; ENSP00000480372; ENSG00000274811. [Q96KA5-1]
GeneIDi81037.
KEGGihsa:81037.
UCSCiuc003jch.4. human. [Q96KA5-1]

Organism-specific databases

CTDi81037.
DisGeNETi81037.
GeneCardsiCLPTM1L.
HGNCiHGNC:24308. CLPTM1L.
HPAiHPA014791.
MIMi612585. gene.
neXtProtiNX_Q96KA5.
OpenTargetsiENSG00000049656.
ENSG00000274811.
PharmGKBiPA147358156.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2489. Eukaryota.
ENOG410XPEV. LUCA.
GeneTreeiENSGT00530000063461.
HOGENOMiHOG000201405.
HOVERGENiHBG057146.
InParanoidiQ96KA5.
OMAiFQFGTYS.
OrthoDBiEOG091G05EF.
PhylomeDBiQ96KA5.
TreeFamiTF318501.

Miscellaneous databases

ChiTaRSiCLPTM1L. human.
GeneWikiiCLPTM1L.
GenomeRNAii81037.
PROiQ96KA5.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000049656.
CleanExiHS_CLPTM1L.
ExpressionAtlasiQ96KA5. baseline and differential.
GenevisibleiQ96KA5. HS.

Family and domain databases

InterProiIPR008429. CLPTM1.
IPR030434. CLPTM1L.
[Graphical view]
PANTHERiPTHR21347. PTHR21347. 1 hit.
PTHR21347:SF1. PTHR21347:SF1. 1 hit.
PfamiPF05602. CLPTM1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCLP1L_HUMAN
AccessioniPrimary (citable) accession number: Q96KA5
Secondary accession number(s): D3DTC1
, Q658W6, Q7LG29, Q96AZ0, Q9H3N4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: December 1, 2001
Last modified: November 2, 2016
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.