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Q96KA5

- CLP1L_HUMAN

UniProt

Q96KA5 - CLP1L_HUMAN

Protein

Cleft lip and palate transmembrane protein 1-like protein

Gene

CLPTM1L

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 100 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    Enhances cisplatin-mediated apoptosis, when overexpressed.1 Publication

    GO - Biological processi

    1. apoptotic process Source: UniProtKB-KW

    Keywords - Biological processi

    Apoptosis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cleft lip and palate transmembrane protein 1-like protein
    Short name:
    CLPTM1-like protein
    Alternative name(s):
    Cisplatin resistance-related protein 9
    Short name:
    CRR9p
    Gene namesi
    Name:CLPTM1L
    Synonyms:CRR9
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 5

    Organism-specific databases

    HGNCiHGNC:24308. CLPTM1L.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. membrane Source: UniProtKB

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA147358156.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 538538Cleft lip and palate transmembrane protein 1-like proteinPRO_0000331300Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi91 – 911N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi101 – 1011N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi229 – 2291N-linked (GlcNAc...)1 Publication

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    MaxQBiQ96KA5.
    PaxDbiQ96KA5.
    PRIDEiQ96KA5.

    PTM databases

    PhosphoSiteiQ96KA5.

    Expressioni

    Inductioni

    Up-regulated by cisplatin.1 Publication

    Gene expression databases

    ArrayExpressiQ96KA5.
    BgeeiQ96KA5.
    CleanExiHS_CLPTM1L.
    GenevestigatoriQ96KA5.

    Organism-specific databases

    HPAiHPA014791.

    Interactioni

    Protein-protein interaction databases

    BioGridi123354. 9 interactions.
    IntActiQ96KA5. 4 interactions.
    MINTiMINT-3054993.
    STRINGi9606.ENSP00000313854.

    Structurei

    3D structure databases

    ProteinModelPortaliQ96KA5.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 1010CytoplasmicSequence Analysis
    Topological domaini32 – 284253ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini306 – 32419CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini343 – 3464ExtracellularSequence Analysis
    Topological domaini365 – 40238CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini424 – 4285ExtracellularSequence Analysis
    Topological domaini450 – 53889CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei11 – 3121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei285 – 30521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei325 – 34218HelicalSequence AnalysisAdd
    BLAST
    Transmembranei347 – 36418HelicalSequence AnalysisAdd
    BLAST
    Transmembranei403 – 42321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei429 – 44921HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the CLPTM1 family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG287859.
    HOGENOMiHOG000201405.
    HOVERGENiHBG057146.
    InParanoidiQ96KA5.
    OMAiFQFGTYS.
    OrthoDBiEOG74N5GH.
    PhylomeDBiQ96KA5.
    TreeFamiTF318501.

    Family and domain databases

    InterProiIPR008429. CLPTM1.
    [Graphical view]
    PANTHERiPTHR21347. PTHR21347. 1 hit.
    PfamiPF05602. CLPTM1. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q96KA5-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MWSGRSSFTS LVVGVFVVYV VHTCWVMYGI VYTRPCSGDA NCIQPYLARR    50
    PKLQLSVYTT TRSHLGAENN IDLVLNVEDF DVESKFERTV NVSVPKKTRN 100
    NGTLYAYIFL HHAGVLPWHD GKQVHLVSPL TTYMVPKPEE INLLTGESDT 150
    QQIEAEKKPT SALDEPVSHW RPRLALNVMA DNFVFDGSSL PADVHRYMKM 200
    IQLGKTVHYL PILFIDQLSN RVKDLMVINR STTELPLTVS YDKVSLGRLR 250
    FWIHMQDAVY SLQQFGFSEK DADEVKGIFV DTNLYFLALT FFVAAFHLLF 300
    DFLAFKNDIS FWKKKKSMIG MSTKAVLWRC FSTVVIFLFL LDEQTSLLVL 350
    VPAGVGAAIE LWKVKKALKM TIFWRGLMPE FQFGTYSESE RKTEEYDTQA 400
    MKYLSYLLYP LCVGGAVYSL LNIKYKSWYS WLINSFVNGV YAFGFLFMLP 450
    QLFVNYKLKS VAHLPWKAFT YKAFNTFIDD VFAFIITMPT SHRLACFRDD 500
    VVFLVYLYQR WLYPVDKRRV NEFGESYEEK ATRAPHTD 538
    Length:538
    Mass (Da):62,229
    Last modified:December 1, 2001 - v1
    Checksum:iA83FF068AED01FC7
    GO
    Isoform 2 (identifier: Q96KA5-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         325-360: Missing.

    Show »
    Length:502
    Mass (Da):58,356
    Checksum:iF336609A093D72AB
    GO

    Sequence cautioni

    The sequence BAB20083.1 differs from that shown. Reason: Erroneous initiation.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti313 – 3131K → N in a breast cancer sample; somatic mutation. 1 Publication
    VAR_042754
    Natural varianti537 – 5371T → M.
    Corresponds to variant rs33955038 [ dbSNP | Ensembl ].
    VAR_042755

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei325 – 36036Missing in isoform 2. 1 PublicationVSP_033157Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK027306 mRNA. Translation: BAB55030.1.
    CH471102 Genomic DNA. Translation: EAX08162.1.
    CH471102 Genomic DNA. Translation: EAX08163.1.
    BC016399 mRNA. Translation: AAH16399.1.
    BC025305 mRNA. Translation: AAH25305.1.
    AB045223 mRNA. Translation: BAB20083.1. Different initiation.
    AL832953 mRNA. Translation: CAH56333.1.
    CCDSiCCDS3862.1. [Q96KA5-1]
    PIRiJC7599.
    RefSeqiNP_110409.2. NM_030782.3. [Q96KA5-1]
    UniGeneiHs.444673.

    Genome annotation databases

    EnsembliENST00000320895; ENSP00000313854; ENSG00000049656. [Q96KA5-1]
    GeneIDi81037.
    KEGGihsa:81037.
    UCSCiuc003jch.3. human. [Q96KA5-1]

    Polymorphism databases

    DMDMi74732209.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK027306 mRNA. Translation: BAB55030.1 .
    CH471102 Genomic DNA. Translation: EAX08162.1 .
    CH471102 Genomic DNA. Translation: EAX08163.1 .
    BC016399 mRNA. Translation: AAH16399.1 .
    BC025305 mRNA. Translation: AAH25305.1 .
    AB045223 mRNA. Translation: BAB20083.1 . Different initiation.
    AL832953 mRNA. Translation: CAH56333.1 .
    CCDSi CCDS3862.1. [Q96KA5-1 ]
    PIRi JC7599.
    RefSeqi NP_110409.2. NM_030782.3. [Q96KA5-1 ]
    UniGenei Hs.444673.

    3D structure databases

    ProteinModelPortali Q96KA5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 123354. 9 interactions.
    IntActi Q96KA5. 4 interactions.
    MINTi MINT-3054993.
    STRINGi 9606.ENSP00000313854.

    PTM databases

    PhosphoSitei Q96KA5.

    Polymorphism databases

    DMDMi 74732209.

    Proteomic databases

    MaxQBi Q96KA5.
    PaxDbi Q96KA5.
    PRIDEi Q96KA5.

    Protocols and materials databases

    DNASUi 81037.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000320895 ; ENSP00000313854 ; ENSG00000049656 . [Q96KA5-1 ]
    GeneIDi 81037.
    KEGGi hsa:81037.
    UCSCi uc003jch.3. human. [Q96KA5-1 ]

    Organism-specific databases

    CTDi 81037.
    GeneCardsi GC05M001317.
    HGNCi HGNC:24308. CLPTM1L.
    HPAi HPA014791.
    MIMi 612585. gene.
    neXtProti NX_Q96KA5.
    PharmGKBi PA147358156.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG287859.
    HOGENOMi HOG000201405.
    HOVERGENi HBG057146.
    InParanoidi Q96KA5.
    OMAi FQFGTYS.
    OrthoDBi EOG74N5GH.
    PhylomeDBi Q96KA5.
    TreeFami TF318501.

    Miscellaneous databases

    ChiTaRSi CLPTM1L. human.
    GeneWikii CLPTM1L.
    GenomeRNAii 81037.
    NextBioi 71380.
    PROi Q96KA5.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q96KA5.
    Bgeei Q96KA5.
    CleanExi HS_CLPTM1L.
    Genevestigatori Q96KA5.

    Family and domain databases

    InterProi IPR008429. CLPTM1.
    [Graphical view ]
    PANTHERi PTHR21347. PTHR21347. 1 hit.
    Pfami PF05602. CLPTM1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Embryo.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 130-538 (ISOFORM 2).
      Tissue: Colon and Ovary.
    4. "A novel gene, CRR9, which was up-regulated in CDDP-resistant ovarian tumor cell line, was associated with apoptosis."
      Yamamoto K., Okamoto A., Isonishi S., Ochiai K., Ohtake Y.
      Biochem. Biophys. Res. Commun. 280:1148-1154(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 6-538 (ISOFORM 1), FUNCTION, INDUCTION.
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 391-538 (ISOFORM 1).
      Tissue: Stomach.
    6. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
      Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
      J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-229.
      Tissue: Liver.
    7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    8. Cited for: VARIANT [LARGE SCALE ANALYSIS] ASN-313.

    Entry informationi

    Entry nameiCLP1L_HUMAN
    AccessioniPrimary (citable) accession number: Q96KA5
    Secondary accession number(s): D3DTC1
    , Q658W6, Q7LG29, Q96AZ0, Q9H3N4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 29, 2008
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 100 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 5
      Human chromosome 5: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3