Reviewed, UniProtKB/Swiss-Prot Q96KA5 (CLP1L_HUMAN)

Names and origin

Protein names

Recommended name:
    Cleft lip and palate transmembrane protein 1-like protein
      Short name=CLPTM1-like protein
Alternative name(s):
    Cisplatin resistance-related protein 9
    CRR9p

Gene names

Name:	CLPTM1L
Synonyms:	CRR9

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	538 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Enhances cisplatin-mediated apoptosis, when overexpressed. Ref.4
Subcellular location	Membrane; Multi-pass membrane protein Potential.
Induction	Up-regulated by cisplatin. Ref.4
Sequence similarities	Belongs to the CLPTM1 family.

Ontologies

Keywords
Biological process	Apoptosis
Cellular component	Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Transmembrane
PTM	Glycoprotein
Gene Ontology (GO)
Biological process	apoptosis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q96KA5-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q96KA5-2)

The sequence of this isoform differs from the canonical sequence as follows:
     325-360: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 538	538	Cleft lip and palate transmembrane protein 1-like protein		PRO_0000331300
Regions
	Topological domain	1 – 10	10	Cytoplasmic Potential
	Transmembrane	11 – 31	21	Potential
	Topological domain	32 – 284	253	Extracellular Potential
	Transmembrane	285 – 305	21	Potential
	Topological domain	306 – 324	19	Cytoplasmic Potential
	Transmembrane	325 – 342	18	Potential
	Topological domain	343 – 346	4	Extracellular Potential
	Transmembrane	347 – 364	18	Potential
	Topological domain	365 – 402	38	Cytoplasmic Potential
	Transmembrane	403 – 423	21	Potential
	Topological domain	424 – 428	5	Extracellular Potential
	Transmembrane	429 – 449	21	Potential
	Topological domain	450 – 538	89	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	91	1	N-linked (GlcNAc...) Potential
	Glycosylation	101	1	N-linked (GlcNAc...) Potential
	Glycosylation	229	1	N-linked (GlcNAc...)
Natural variations
	Alternative sequence	325 – 360	36	Missing in isoform 2.		VSP_033157
	Natural variant	313	1	K → N in a breast cancer sample; somatic mutation. Ref.8		VAR_042754
	Natural variant	537	1	T → M: dbSNP rs33955038.		VAR_042755

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: A83FF068AED01FC7	FASTA	538	62,229
	10 20 30 40 50 60 MWSGRSSFTS LVVGVFVVYV VHTCWVMYGI VYTRPCSGDA NCIQPYLARR PKLQLSVYTT 70 80 90 100 110 120 TRSHLGAENN IDLVLNVEDF DVESKFERTV NVSVPKKTRN NGTLYAYIFL HHAGVLPWHD 130 140 150 160 170 180 GKQVHLVSPL TTYMVPKPEE INLLTGESDT QQIEAEKKPT SALDEPVSHW RPRLALNVMA 190 200 210 220 230 240 DNFVFDGSSL PADVHRYMKM IQLGKTVHYL PILFIDQLSN RVKDLMVINR STTELPLTVS 250 260 270 280 290 300 YDKVSLGRLR FWIHMQDAVY SLQQFGFSEK DADEVKGIFV DTNLYFLALT FFVAAFHLLF 310 320 330 340 350 360 DFLAFKNDIS FWKKKKSMIG MSTKAVLWRC FSTVVIFLFL LDEQTSLLVL VPAGVGAAIE 370 380 390 400 410 420 LWKVKKALKM TIFWRGLMPE FQFGTYSESE RKTEEYDTQA MKYLSYLLYP LCVGGAVYSL 430 440 450 460 470 480 LNIKYKSWYS WLINSFVNGV YAFGFLFMLP QLFVNYKLKS VAHLPWKAFT YKAFNTFIDD 490 500 510 520 530 VFAFIITMPT SHRLACFRDD VVFLVYLYQR WLYPVDKRRV NEFGESYEEK ATRAPHTD
	Isoform 2. Checksum: F336609A093D72AB	FASTA	502	58,356
	10 20 30 40 50 60 MWSGRSSFTS LVVGVFVVYV VHTCWVMYGI VYTRPCSGDA NCIQPYLARR PKLQLSVYTT 70 80 90 100 110 120 TRSHLGAENN IDLVLNVEDF DVESKFERTV NVSVPKKTRN NGTLYAYIFL HHAGVLPWHD 130 140 150 160 170 180 GKQVHLVSPL TTYMVPKPEE INLLTGESDT QQIEAEKKPT SALDEPVSHW RPRLALNVMA 190 200 210 220 230 240 DNFVFDGSSL PADVHRYMKM IQLGKTVHYL PILFIDQLSN RVKDLMVINR STTELPLTVS 250 260 270 280 290 300 YDKVSLGRLR FWIHMQDAVY SLQQFGFSEK DADEVKGIFV DTNLYFLALT FFVAAFHLLF 310 320 330 340 350 360 DFLAFKNDIS FWKKKKSMIG MSTKLWKVKK ALKMTIFWRG LMPEFQFGTY SESERKTEEY 370 380 390 400 410 420 DTQAMKYLSY LLYPLCVGGA VYSLLNIKYK SWYSWLINSF VNGVYAFGFL FMLPQLFVNY 430 440 450 460 470 480 KLKSVAHLPW KAFTYKAFNT FIDDVFAFII TMPTSHRLAC FRDDVVFLVY LYQRWLYPVD 490 500 KRRVNEFGES YEEKATRAPH TD

References

[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Embryo.
[2]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 130-538 (ISOFORM 2). Tissue: Colon and Ovary.
[4]	"A novel gene, CRR9, which was up-regulated in CDDP-resistant ovarian tumor cell line, was associated with apoptosis." Yamamoto K., Okamoto A., Isonishi S., Ochiai K., Ohtake Y. Biochem. Biophys. Res. Commun. 280:1148-1154(2001) [PubMed: 11162647] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 6-538 (ISOFORM 1), FUNCTION, INDUCTION.
[5]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Blocker H., Heubner D., Hoerlein A., Michel G., Wedler H., Kohrer K., Ottenwalder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed: 17974005] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 391-538 (ISOFORM 1). Tissue: Stomach.
[6]	Colinge J., Superti-Furga G., Bennett K.L. Submitted (OCT-2008) to UniProtKB Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY.
[7]	"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry." Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H. J. Proteome Res. 8:651-661(2009) [PubMed: 19159218] [Abstract] Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-229, MASS SPECTROMETRY. Tissue: Liver.
[8]	"The consensus coding sequences of human breast and colorectal cancers." Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E. Science 314:268-274(2006) [PubMed: 16959974] [Abstract] Cited for: VARIANT [LARGE SCALE ANALYSIS] ASN-313.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AK027306 mRNA. Translation: BAB55030.1. CH471102 Genomic DNA. Translation: EAX08162.1. BC016399 mRNA. Translation: AAH16399.1. BC025305 mRNA. Translation: AAH25305.1. AB045223 mRNA. Translation: BAB20083.1. Different initiation. AL832953 mRNA. Translation: CAH56333.1.
IPI	IPI00151358. IPI00186429.
PIR	JC7599.
RefSeq	NP_110409.2.
UniGene	Hs.444673
3D structure databases
ModBase	Search...
Proteomic databases
PRIDE	Q96KA5.
Genome annotation databases
Ensembl	ENSG00000049656. Homo sapiens. [Contig view]
GeneID	81037.
KEGG	hsa:81037.
Organism-specific databases
GeneCards	GC05M001371.
HGNC	HGNC:24308. CLPTM1L.
HPA	HPA014791.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	Q96KA5.
HOVERGEN	Q96KA5.
OMA	Q96KA5. HRYMKMI.
Gene expression databases
ArrayExpress	Q96KA5.
Bgee	Q96KA5.
CleanEx	HS_CLPTM1L.
Family and domain databases
InterPro	IPR008429. CLPTM1. [Graphical view]
PANTHER	PTHR21347. CLPTM1. 1 hit.
Pfam	PF05602. CLPTM1. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	71380.

Entry information

Entry name

CLP1L_HUMAN

Accession

Primary (citable) accession number: Q96KA5
Secondary accession number(s): Q658W6 , Q7LG29, Q96AZ0, Q9H3N4

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 29, 2008
Last sequence update:	December 1, 2001
Last modified:	June 16, 2009
This is version 54 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)