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Protein

Zinc finger CCCH domain-containing protein 10

Gene

ZC3H10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri36 – 63C3H1-type 1PROSITE-ProRule annotationAdd BLAST28
Zinc fingeri73 – 99C3H1-type 2PROSITE-ProRule annotationAdd BLAST27
Zinc fingeri134 – 161C3H1-type 3PROSITE-ProRule annotationAdd BLAST28

GO - Molecular functioni

  • metal ion binding Source: UniProtKB-KW
  • RNA binding Source: UniProtKB

Keywordsi

LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger CCCH domain-containing protein 10
Gene namesi
Name:ZC3H10
Synonyms:ZC3HDC10
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000135482.6.
HGNCiHGNC:25893. ZC3H10.

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000135482.
PharmGKBiPA142670534.

Polymorphism and mutation databases

BioMutaiZC3H10.
DMDMi74760908.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002811451 – 434Zinc finger CCCH domain-containing protein 10Add BLAST434

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei185Omega-N-methylarginineBy similarity1
Modified residuei186Omega-N-methylarginineBy similarity1

Keywords - PTMi

Methylation

Proteomic databases

EPDiQ96K80.
MaxQBiQ96K80.
PaxDbiQ96K80.
PeptideAtlasiQ96K80.
PRIDEiQ96K80.

PTM databases

iPTMnetiQ96K80.
PhosphoSitePlusiQ96K80.

Expressioni

Gene expression databases

BgeeiENSG00000135482.
CleanExiHS_ZC3H10.
ExpressionAtlasiQ96K80. baseline and differential.
GenevisibleiQ96K80. HS.

Organism-specific databases

HPAiHPA039236.
HPA062265.

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi124317. 16 interactors.
IntActiQ96K80. 37 interactors.
MINTiMINT-1446979.
STRINGi9606.ENSP00000257940.

Structurei

3D structure databases

ProteinModelPortaliQ96K80.
SMRiQ96K80.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili234 – 280Sequence analysisAdd BLAST47

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi10 – 35Gly-richAdd BLAST26
Compositional biasi169 – 176Poly-Gly8
Compositional biasi323 – 396Pro-richAdd BLAST74

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri36 – 63C3H1-type 1PROSITE-ProRule annotationAdd BLAST28
Zinc fingeri73 – 99C3H1-type 2PROSITE-ProRule annotationAdd BLAST27
Zinc fingeri134 – 161C3H1-type 3PROSITE-ProRule annotationAdd BLAST28

Keywords - Domaini

Coiled coil, Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG2494. Eukaryota.
ENOG410ZNRC. LUCA.
GeneTreeiENSGT00390000005669.
HOGENOMiHOG000273882.
HOVERGENiHBG060393.
InParanoidiQ96K80.
OMAiTMSHATT.
OrthoDBiEOG091G0G1H.
PhylomeDBiQ96K80.
TreeFamiTF321931.

Family and domain databases

Gene3Di4.10.1000.10. 2 hits.
InterProiView protein in InterPro
IPR000571. Znf_CCCH.
PfamiView protein in Pfam
PF00642. zf-CCCH. 2 hits.
SMARTiView protein in SMART
SM00356. ZnF_C3H1. 3 hits.
PROSITEiView protein in PROSITE
PS50103. ZF_C3H1. 3 hits.

Sequencei

Sequence statusi: Complete.

Q96K80-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPDRDSYANG TGSSGGGPGG GGSEEASGAG VGSGGASSDA ICRDFLRNVC
60 70 80 90 100
KRGKRCRYRH PDMSEVSNLG VSKNEFIFCH DFQNKECSRP NCRFIHGSKE
110 120 130 140 150
DEDGYKKTGE LPPRLRQKVA AGLGLSPADL PNGKEEVPIC RDFLKGDCQR
160 170 180 190 200
GAKCKFRHLQ RDFEFDARGG GGTGGGSTGS VLPGRRHDLY DIYDLPDRGF
210 220 230 240 250
EDHEPGPKRR RGGCCPPDGP HFESYEYSLA PPRGVECRLL EEENAMLRKR
260 270 280 290 300
VEELKKQVSN LLATNEVLLE QNAQFRNQAK VITLSSTAPA TEQTLAPTVG
310 320 330 340 350
TVATFNHGIA QTHTTLSSQA LQPRPVSQQE LVAPAGAPAA PPTNAAPPAA
360 370 380 390 400
PPPPPPHLTP EITPLSAALA QTIAQGMAPP PVSMAPVAVS VAPVAPVAVS
410 420 430
MAQPLAGITM SHTTTPMVTY PIASQSMRIT AMPH
Length:434
Mass (Da):46,052
Last modified:December 1, 2001 - v1
Checksum:iE4B24A526F3A573B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK027357 mRNA. Translation: BAB55059.1.
BC018708 mRNA. Translation: AAH18708.1.
CCDSiCCDS8903.1.
RefSeqiNP_001290053.1. NM_001303124.1.
NP_001290054.1. NM_001303125.1.
NP_116175.1. NM_032786.2.
UniGeneiHs.632706.

Genome annotation databases

EnsembliENST00000257940; ENSP00000257940; ENSG00000135482.
GeneIDi84872.
KEGGihsa:84872.
UCSCiuc001sjp.2. human.

Similar proteinsi

Entry informationi

Entry nameiZC3HA_HUMAN
AccessioniPrimary (citable) accession number: Q96K80
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: December 1, 2001
Last modified: September 27, 2017
This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM