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Protein

Zinc finger CCCH domain-containing protein 10

Gene

ZC3H10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri36 – 6328C3H1-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri73 – 9927C3H1-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri134 – 16128C3H1-type 3PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  • metal ion binding Source: UniProtKB-KW
  • poly(A) RNA binding Source: UniProtKB
Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger CCCH domain-containing protein 10
Gene namesi
Name:ZC3H10
Synonyms:ZC3HDC10
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:25893. ZC3H10.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142670534.

Polymorphism and mutation databases

BioMutaiZC3H10.
DMDMi74760908.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 434434Zinc finger CCCH domain-containing protein 10PRO_0000281145Add
BLAST

Proteomic databases

EPDiQ96K80.
MaxQBiQ96K80.
PaxDbiQ96K80.
PeptideAtlasiQ96K80.
PRIDEiQ96K80.

PTM databases

iPTMnetiQ96K80.
PhosphoSiteiQ96K80.

Expressioni

Gene expression databases

BgeeiENSG00000135482.
CleanExiHS_ZC3H10.
ExpressionAtlasiQ96K80. baseline and differential.
GenevisibleiQ96K80. HS.

Organism-specific databases

HPAiHPA039236.
HPA062265.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
APPBP2Q926243EBI-742550,EBI-743771
ATXN1P542534EBI-742550,EBI-930964
DAB1O755533EBI-742550,EBI-7875264
PRR20CP864793EBI-742550,EBI-10172814
RBPMSQ930624EBI-742550,EBI-740322

Protein-protein interaction databases

BioGridi124317. 15 interactions.
IntActiQ96K80. 6 interactions.
MINTiMINT-1446979.
STRINGi9606.ENSP00000257940.

Structurei

3D structure databases

ProteinModelPortaliQ96K80.
SMRiQ96K80. Positions 131-161.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili234 – 28047Sequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi10 – 3526Gly-richAdd
BLAST
Compositional biasi169 – 1768Poly-Gly
Compositional biasi323 – 39674Pro-richAdd
BLAST

Sequence similaritiesi

Contains 3 C3H1-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri36 – 6328C3H1-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri73 – 9927C3H1-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri134 – 16128C3H1-type 3PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Coiled coil, Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG2494. Eukaryota.
ENOG410ZNRC. LUCA.
GeneTreeiENSGT00390000005669.
HOGENOMiHOG000273882.
HOVERGENiHBG060393.
InParanoidiQ96K80.
OMAiQSMRITT.
OrthoDBiEOG091G0G1H.
PhylomeDBiQ96K80.
TreeFamiTF321931.

Family and domain databases

Gene3Di4.10.1000.10. 1 hit.
InterProiIPR000571. Znf_CCCH.
[Graphical view]
PfamiPF00642. zf-CCCH. 2 hits.
[Graphical view]
SMARTiSM00356. ZnF_C3H1. 3 hits.
[Graphical view]
PROSITEiPS50103. ZF_C3H1. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96K80-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPDRDSYANG TGSSGGGPGG GGSEEASGAG VGSGGASSDA ICRDFLRNVC
60 70 80 90 100
KRGKRCRYRH PDMSEVSNLG VSKNEFIFCH DFQNKECSRP NCRFIHGSKE
110 120 130 140 150
DEDGYKKTGE LPPRLRQKVA AGLGLSPADL PNGKEEVPIC RDFLKGDCQR
160 170 180 190 200
GAKCKFRHLQ RDFEFDARGG GGTGGGSTGS VLPGRRHDLY DIYDLPDRGF
210 220 230 240 250
EDHEPGPKRR RGGCCPPDGP HFESYEYSLA PPRGVECRLL EEENAMLRKR
260 270 280 290 300
VEELKKQVSN LLATNEVLLE QNAQFRNQAK VITLSSTAPA TEQTLAPTVG
310 320 330 340 350
TVATFNHGIA QTHTTLSSQA LQPRPVSQQE LVAPAGAPAA PPTNAAPPAA
360 370 380 390 400
PPPPPPHLTP EITPLSAALA QTIAQGMAPP PVSMAPVAVS VAPVAPVAVS
410 420 430
MAQPLAGITM SHTTTPMVTY PIASQSMRIT AMPH
Length:434
Mass (Da):46,052
Last modified:December 1, 2001 - v1
Checksum:iE4B24A526F3A573B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK027357 mRNA. Translation: BAB55059.1.
BC018708 mRNA. Translation: AAH18708.1.
CCDSiCCDS8903.1.
RefSeqiNP_001290053.1. NM_001303124.1.
NP_001290054.1. NM_001303125.1.
NP_116175.1. NM_032786.2.
UniGeneiHs.632706.

Genome annotation databases

EnsembliENST00000257940; ENSP00000257940; ENSG00000135482.
GeneIDi84872.
KEGGihsa:84872.
UCSCiuc001sjp.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK027357 mRNA. Translation: BAB55059.1.
BC018708 mRNA. Translation: AAH18708.1.
CCDSiCCDS8903.1.
RefSeqiNP_001290053.1. NM_001303124.1.
NP_001290054.1. NM_001303125.1.
NP_116175.1. NM_032786.2.
UniGeneiHs.632706.

3D structure databases

ProteinModelPortaliQ96K80.
SMRiQ96K80. Positions 131-161.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124317. 15 interactions.
IntActiQ96K80. 6 interactions.
MINTiMINT-1446979.
STRINGi9606.ENSP00000257940.

PTM databases

iPTMnetiQ96K80.
PhosphoSiteiQ96K80.

Polymorphism and mutation databases

BioMutaiZC3H10.
DMDMi74760908.

Proteomic databases

EPDiQ96K80.
MaxQBiQ96K80.
PaxDbiQ96K80.
PeptideAtlasiQ96K80.
PRIDEiQ96K80.

Protocols and materials databases

DNASUi84872.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000257940; ENSP00000257940; ENSG00000135482.
GeneIDi84872.
KEGGihsa:84872.
UCSCiuc001sjp.2. human.

Organism-specific databases

CTDi84872.
GeneCardsiZC3H10.
HGNCiHGNC:25893. ZC3H10.
HPAiHPA039236.
HPA062265.
neXtProtiNX_Q96K80.
PharmGKBiPA142670534.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2494. Eukaryota.
ENOG410ZNRC. LUCA.
GeneTreeiENSGT00390000005669.
HOGENOMiHOG000273882.
HOVERGENiHBG060393.
InParanoidiQ96K80.
OMAiQSMRITT.
OrthoDBiEOG091G0G1H.
PhylomeDBiQ96K80.
TreeFamiTF321931.

Miscellaneous databases

GenomeRNAii84872.
PROiQ96K80.

Gene expression databases

BgeeiENSG00000135482.
CleanExiHS_ZC3H10.
ExpressionAtlasiQ96K80. baseline and differential.
GenevisibleiQ96K80. HS.

Family and domain databases

Gene3Di4.10.1000.10. 1 hit.
InterProiIPR000571. Znf_CCCH.
[Graphical view]
PfamiPF00642. zf-CCCH. 2 hits.
[Graphical view]
SMARTiSM00356. ZnF_C3H1. 3 hits.
[Graphical view]
PROSITEiPS50103. ZF_C3H1. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZC3HA_HUMAN
AccessioniPrimary (citable) accession number: Q96K80
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: December 1, 2001
Last modified: September 7, 2016
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.