ID   AGRG7_HUMAN             Reviewed;         797 AA.
AC   Q96K78; Q14D94; Q86SQ2;
DT   29-MAR-2004, integrated into UniProtKB/Swiss-Prot.
DT   05-MAY-2009, sequence version 2.
DT   27-MAR-2024, entry version 165.
DE   RecName: Full=Adhesion G-protein coupled receptor G7 {ECO:0000303|PubMed:25713288};
DE   AltName: Full=G-protein coupled receptor 128;
DE   Flags: Precursor;
GN   Name=ADGRG7; Synonyms=GPR128;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=12565841; DOI=10.1016/s0006-291x(03)00026-3;
RA   Fredriksson R., Gloriam D.E.I., Hoeglund P.J., Lagerstroem M.C.,
RA   Schioeth H.B.;
RT   "There exist at least 30 human G-protein-coupled receptors with long
RT   Ser/Thr-rich N-termini.";
RL   Biochem. Biophys. Res. Commun. 301:725-734(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT GLU-151.
RC   TISSUE=Embryo;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [5]
RP   NOMENCLATURE.
RX   PubMed=25713288; DOI=10.1124/pr.114.009647;
RA   Hamann J., Aust G., Arac D., Engel F.B., Formstone C., Fredriksson R.,
RA   Hall R.A., Harty B.L., Kirchhoff C., Knapp B., Krishnan A., Liebscher I.,
RA   Lin H.H., Martinelli D.C., Monk K.R., Peeters M.C., Piao X., Promel S.,
RA   Schoneberg T., Schwartz T.W., Singer K., Stacey M., Ushkaryov Y.A.,
RA   Vallon M., Wolfrum U., Wright M.W., Xu L., Langenhan T., Schioth H.B.;
RT   "International union of basic and clinical pharmacology. XCIV. Adhesion G
RT   protein-coupled receptors.";
RL   Pharmacol. Rev. 67:338-367(2015).
CC   -!- FUNCTION: Orphan receptor.
CC   -!- INTERACTION:
CC       Q96K78; Q5T700: LDLRAD1; NbExp=7; IntAct=EBI-10290200, EBI-10173166;
CC       Q96K78; Q99523: SORT1; NbExp=3; IntAct=EBI-10290200, EBI-1057058;
CC       Q96K78; Q9P0L0: VAPA; NbExp=3; IntAct=EBI-10290200, EBI-1059156;
CC       Q96K78; A8KA83; NbExp=3; IntAct=EBI-10290200, EBI-10174961;
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane
CC       protein {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 2 family.
CC       Adhesion G-protein coupled receptor (ADGR) subfamily. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAO27358.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AY181246; AAO27358.1; ALT_INIT; mRNA.
DR   EMBL; AK027360; BAB55061.1; -; mRNA.
DR   EMBL; CH471052; EAW79818.1; -; Genomic_DNA.
DR   EMBL; BC113451; AAI13452.1; -; mRNA.
DR   CCDS; CCDS2938.1; -.
DR   RefSeq; NP_116176.2; NM_032787.2.
DR   AlphaFoldDB; Q96K78; -.
DR   SMR; Q96K78; -.
DR   BioGRID; 124318; 4.
DR   IntAct; Q96K78; 4.
DR   STRING; 9606.ENSP00000273352; -.
DR   MEROPS; P02.020; -.
DR   GlyCosmos; Q96K78; 10 sites, No reported glycans.
DR   GlyGen; Q96K78; 10 sites.
DR   iPTMnet; Q96K78; -.
DR   PhosphoSitePlus; Q96K78; -.
DR   BioMuta; ADGRG7; -.
DR   DMDM; 229462926; -.
DR   MassIVE; Q96K78; -.
DR   PaxDb; 9606-ENSP00000273352; -.
DR   PeptideAtlas; Q96K78; -.
DR   ProteomicsDB; 77050; -.
DR   Antibodypedia; 15851; 131 antibodies from 24 providers.
DR   DNASU; 84873; -.
DR   Ensembl; ENST00000273352.8; ENSP00000273352.3; ENSG00000144820.8.
DR   GeneID; 84873; -.
DR   KEGG; hsa:84873; -.
DR   MANE-Select; ENST00000273352.8; ENSP00000273352.3; NM_032787.3; NP_116176.2.
DR   UCSC; uc003duc.5; human.
DR   AGR; HGNC:19241; -.
DR   CTD; 84873; -.
DR   DisGeNET; 84873; -.
DR   GeneCards; ADGRG7; -.
DR   HGNC; HGNC:19241; ADGRG7.
DR   HPA; ENSG00000144820; Group enriched (intestine, liver).
DR   MIM; 612307; gene.
DR   neXtProt; NX_Q96K78; -.
DR   OpenTargets; ENSG00000144820; -.
DR   PharmGKB; PA134982718; -.
DR   VEuPathDB; HostDB:ENSG00000144820; -.
DR   eggNOG; KOG4193; Eukaryota.
DR   GeneTree; ENSGT00940000159169; -.
DR   HOGENOM; CLU_370321_0_0_1; -.
DR   InParanoid; Q96K78; -.
DR   OMA; RCTIVNF; -.
DR   OrthoDB; 5400300at2759; -.
DR   PhylomeDB; Q96K78; -.
DR   TreeFam; TF351485; -.
DR   PathwayCommons; Q96K78; -.
DR   SignaLink; Q96K78; -.
DR   BioGRID-ORCS; 84873; 11 hits in 1147 CRISPR screens.
DR   ChiTaRS; ADGRG7; human.
DR   GenomeRNAi; 84873; -.
DR   Pharos; Q96K78; Tbio.
DR   PRO; PR:Q96K78; -.
DR   Proteomes; UP000005640; Chromosome 3.
DR   RNAct; Q96K78; Protein.
DR   Bgee; ENSG00000144820; Expressed in jejunal mucosa and 99 other cell types or tissues.
DR   ExpressionAtlas; Q96K78; baseline and differential.
DR   GO; GO:0016020; C:membrane; TAS:GDB.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IBA:GO_Central.
DR   GO; GO:0007189; P:adenylate cyclase-activating G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR   GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR   GO; GO:0007186; P:G protein-coupled receptor signaling pathway; TAS:GDB.
DR   CDD; cd15257; 7tmB2_GPR128; 1.
DR   Gene3D; 2.60.220.50; -; 1.
DR   Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR   InterPro; IPR046338; GAIN_dom_sf.
DR   InterPro; IPR017981; GPCR_2-like_7TM.
DR   InterPro; IPR000832; GPCR_2_secretin-like.
DR   InterPro; IPR047938; GPR128_7tmB2.
DR   InterPro; IPR000203; GPS.
DR   PANTHER; PTHR47767; ADHESION G PROTEIN-COUPLED RECEPTOR G7; 1.
DR   PANTHER; PTHR47767:SF1; ADHESION G-PROTEIN COUPLED RECEPTOR G7; 1.
DR   Pfam; PF00002; 7tm_2; 1.
DR   Pfam; PF01825; GPS; 1.
DR   PRINTS; PR00249; GPCRSECRETIN.
DR   SMART; SM00303; GPS; 1.
DR   SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR   PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
DR   PROSITE; PS50221; GPS; 1.
DR   Genevisible; Q96K78; HS.
PE   1: Evidence at protein level;
KW   G-protein coupled receptor; Glycoprotein; Membrane; Receptor;
KW   Reference proteome; Signal; Transducer; Transmembrane; Transmembrane helix.
FT   SIGNAL          1..26
FT                   /evidence="ECO:0000255"
FT   CHAIN           27..797
FT                   /note="Adhesion G-protein coupled receptor G7"
FT                   /id="PRO_0000012903"
FT   TOPO_DOM        27..438
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        439..459
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        460..468
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        469..489
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        490..528
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        529..549
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        550..565
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        566..586
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        587..623
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        624..644
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        645..669
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        670..690
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        691..698
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        699..719
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        720..797
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          380..427
FT                   /note="GPS"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00098"
FT   CARBOHYD        82
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        159
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        178
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        191
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        247
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        261
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        312
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        316
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        387
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        413
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   VARIANT         151
FT                   /note="K -> E (in dbSNP:rs1144122)"
FT                   /evidence="ECO:0000269|PubMed:14702039"
FT                   /id="VAR_055138"
FT   VARIANT         645
FT                   /note="T -> S (in dbSNP:rs16842529)"
FT                   /id="VAR_049459"
FT   VARIANT         756
FT                   /note="R -> H (in dbSNP:rs9872512)"
FT                   /id="VAR_049460"
SQ   SEQUENCE   797 AA;  88909 MW;  D6CAAA78AC0E4679 CRC64;
     MASCRAWNLR VLVAVVCGLL TGIILGLGIW RIVIRIQRGK STSSSSTPTE FCRNGGTWEN
     GRCICTEEWK GLRCTIANFC ENSTYMGFTF ARIPVGRYGP SLQTCGKDTP NAGNPMAVRL
     CSLSLYGEIE LQKVTIGNCN ENLETLEKQV KDVTAPLNNI SSEVQILTSD ANKLTAENIT
     SATRVVGQIF NTSRNASPEA KKVAIVTVSQ LLDASEDAFQ RVAATANDDA LTTLIEQMET
     YSLSLGNQSV VEPNIAIQSA NFSSENAVGP SNVRFSVQKG ASSSLVSSST FIHTNVDGLN
     PDAQTELQVL LNMTKNYTKT CGFVVYQNDK LFQSKTFTAK SDFSQKIISS KTDENEQDQS
     ASVDMVFSPK YNQKEFQLYS YACVYWNLSA KDWDTYGCQK DKGTDGFLRC RCNHTTNFAV
     LMTFKKDYQY PKSLDILSNV GCALSVTGLA LTVIFQIVTR KVRKTSVTWV LVNLCISMLI
     FNLLFVFGIE NSNKNLQTSD GDINNIDFDN NDIPRTDTIN IPNPMCTAIA ALLHYFLLVT
     FTWNALSAAQ LYYLLIRTMK PLPRHFILFI SLIGWGVPAI VVAITVGVIY SQNGNNPQWE
     LDYRQEKICW LAIPEPNGVI KSPLLWSFIV PVTIILISNV VMFITISIKV LWKNNQNLTS
     TKKVSSMKKI VSTLSVAVVF GITWILAYLM LVNDDSIRIV FSYIFCLFNT TQGLQIFILY
     TVRTKVFQSE ASKVLMLLSS IGRRKSLPSV TRPRLRVKMY NFLRSLPTLH ERFRLLETSP
     STEEITLSES DNAKESI
//