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Protein

Adhesion G-protein coupled receptor G7

Gene

ADGRG7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Orphan receptor.

GO - Molecular functioni

  • G-protein coupled receptor activity Source: GDB

GO - Biological processi

  • cell surface receptor signaling pathway Source: InterPro
  • G-protein coupled receptor signaling pathway Source: GDB
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

BioCyciZFISH:ENSG00000144820-MONOMER.

Protein family/group databases

MEROPSiP02.020.

Names & Taxonomyi

Protein namesi
Recommended name:
Adhesion G-protein coupled receptor G71 Publication
Alternative name(s):
G-protein coupled receptor 128
Gene namesi
Name:ADGRG7
Synonyms:GPR128
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:19241. ADGRG7.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini27 – 438ExtracellularSequence analysisAdd BLAST412
Transmembranei439 – 459Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini460 – 468CytoplasmicSequence analysis9
Transmembranei469 – 489Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini490 – 528ExtracellularSequence analysisAdd BLAST39
Transmembranei529 – 549Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini550 – 565CytoplasmicSequence analysisAdd BLAST16
Transmembranei566 – 586Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini587 – 623ExtracellularSequence analysisAdd BLAST37
Transmembranei624 – 644Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini645 – 669CytoplasmicSequence analysisAdd BLAST25
Transmembranei670 – 690Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini691 – 698ExtracellularSequence analysis8
Transmembranei699 – 719Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini720 – 797CytoplasmicSequence analysisAdd BLAST78

GO - Cellular componenti

  • integral component of membrane Source: GDB
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi84873.
OpenTargetsiENSG00000144820.
PharmGKBiPA134982718.

Polymorphism and mutation databases

BioMutaiGPR128.
DMDMi229462926.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Sequence analysisAdd BLAST26
ChainiPRO_000001290327 – 797Adhesion G-protein coupled receptor G7Add BLAST771

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi82N-linked (GlcNAc...)Sequence analysis1
Glycosylationi159N-linked (GlcNAc...)Sequence analysis1
Glycosylationi178N-linked (GlcNAc...)Sequence analysis1
Glycosylationi191N-linked (GlcNAc...)Sequence analysis1
Glycosylationi247N-linked (GlcNAc...)Sequence analysis1
Glycosylationi261N-linked (GlcNAc...)Sequence analysis1
Glycosylationi312N-linked (GlcNAc...)Sequence analysis1
Glycosylationi316N-linked (GlcNAc...)Sequence analysis1
Glycosylationi387N-linked (GlcNAc...)Sequence analysis1
Glycosylationi413N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ96K78.
PeptideAtlasiQ96K78.
PRIDEiQ96K78.

PTM databases

iPTMnetiQ96K78.
PhosphoSitePlusiQ96K78.

Expressioni

Gene expression databases

BgeeiENSG00000144820.
CleanExiHS_GPR128.
ExpressionAtlasiQ96K78. baseline and differential.
GenevisibleiQ96K78. HS.

Organism-specific databases

HPAiHPA021135.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
A8KA833EBI-10290200,EBI-10174961
LDLRAD1Q5T7003EBI-10290200,EBI-10173166

Protein-protein interaction databases

BioGridi124318. 2 interactors.
IntActiQ96K78. 3 interactors.
STRINGi9606.ENSP00000273352.

Structurei

3D structure databases

ProteinModelPortaliQ96K78.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini380 – 427GPSPROSITE-ProRule annotationAdd BLAST48

Sequence similaritiesi

Contains 1 GPS domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4193. Eukaryota.
ENOG410XSD2. LUCA.
GeneTreeiENSGT00830000128272.
HOGENOMiHOG000236310.
HOVERGENiHBG063831.
InParanoidiQ96K78.
KOiK08464.
OMAiCICTEEW.
OrthoDBiEOG091G03DK.
PhylomeDBiQ96K78.
TreeFamiTF351485.

Family and domain databases

InterProiIPR017981. GPCR_2-like.
IPR000832. GPCR_2_secretin-like.
IPR000203. GPS.
[Graphical view]
PfamiPF00002. 7tm_2. 1 hit.
PF01825. GPS. 1 hit.
[Graphical view]
PRINTSiPR00249. GPCRSECRETIN.
SMARTiSM00303. GPS. 1 hit.
[Graphical view]
PROSITEiPS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
PS50221. GPS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q96K78-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASCRAWNLR VLVAVVCGLL TGIILGLGIW RIVIRIQRGK STSSSSTPTE
60 70 80 90 100
FCRNGGTWEN GRCICTEEWK GLRCTIANFC ENSTYMGFTF ARIPVGRYGP
110 120 130 140 150
SLQTCGKDTP NAGNPMAVRL CSLSLYGEIE LQKVTIGNCN ENLETLEKQV
160 170 180 190 200
KDVTAPLNNI SSEVQILTSD ANKLTAENIT SATRVVGQIF NTSRNASPEA
210 220 230 240 250
KKVAIVTVSQ LLDASEDAFQ RVAATANDDA LTTLIEQMET YSLSLGNQSV
260 270 280 290 300
VEPNIAIQSA NFSSENAVGP SNVRFSVQKG ASSSLVSSST FIHTNVDGLN
310 320 330 340 350
PDAQTELQVL LNMTKNYTKT CGFVVYQNDK LFQSKTFTAK SDFSQKIISS
360 370 380 390 400
KTDENEQDQS ASVDMVFSPK YNQKEFQLYS YACVYWNLSA KDWDTYGCQK
410 420 430 440 450
DKGTDGFLRC RCNHTTNFAV LMTFKKDYQY PKSLDILSNV GCALSVTGLA
460 470 480 490 500
LTVIFQIVTR KVRKTSVTWV LVNLCISMLI FNLLFVFGIE NSNKNLQTSD
510 520 530 540 550
GDINNIDFDN NDIPRTDTIN IPNPMCTAIA ALLHYFLLVT FTWNALSAAQ
560 570 580 590 600
LYYLLIRTMK PLPRHFILFI SLIGWGVPAI VVAITVGVIY SQNGNNPQWE
610 620 630 640 650
LDYRQEKICW LAIPEPNGVI KSPLLWSFIV PVTIILISNV VMFITISIKV
660 670 680 690 700
LWKNNQNLTS TKKVSSMKKI VSTLSVAVVF GITWILAYLM LVNDDSIRIV
710 720 730 740 750
FSYIFCLFNT TQGLQIFILY TVRTKVFQSE ASKVLMLLSS IGRRKSLPSV
760 770 780 790
TRPRLRVKMY NFLRSLPTLH ERFRLLETSP STEEITLSES DNAKESI
Length:797
Mass (Da):88,909
Last modified:May 5, 2009 - v2
Checksum:iD6CAAA78AC0E4679
GO

Sequence cautioni

The sequence AAO27358 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_055138151K → E.1 PublicationCorresponds to variant rs1144122dbSNPEnsembl.1
Natural variantiVAR_049459645T → S.Corresponds to variant rs16842529dbSNPEnsembl.1
Natural variantiVAR_049460756R → H.Corresponds to variant rs9872512dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY181246 mRNA. Translation: AAO27358.1. Different initiation.
AK027360 mRNA. Translation: BAB55061.1.
CH471052 Genomic DNA. Translation: EAW79818.1.
BC113451 mRNA. Translation: AAI13452.1.
CCDSiCCDS2938.1.
RefSeqiNP_116176.2. NM_032787.2.
UniGeneiHs.334511.

Genome annotation databases

EnsembliENST00000273352; ENSP00000273352; ENSG00000144820.
GeneIDi84873.
KEGGihsa:84873.
UCSCiuc003duc.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY181246 mRNA. Translation: AAO27358.1. Different initiation.
AK027360 mRNA. Translation: BAB55061.1.
CH471052 Genomic DNA. Translation: EAW79818.1.
BC113451 mRNA. Translation: AAI13452.1.
CCDSiCCDS2938.1.
RefSeqiNP_116176.2. NM_032787.2.
UniGeneiHs.334511.

3D structure databases

ProteinModelPortaliQ96K78.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124318. 2 interactors.
IntActiQ96K78. 3 interactors.
STRINGi9606.ENSP00000273352.

Protein family/group databases

MEROPSiP02.020.
GPCRDBiSearch...

PTM databases

iPTMnetiQ96K78.
PhosphoSitePlusiQ96K78.

Polymorphism and mutation databases

BioMutaiGPR128.
DMDMi229462926.

Proteomic databases

PaxDbiQ96K78.
PeptideAtlasiQ96K78.
PRIDEiQ96K78.

Protocols and materials databases

DNASUi84873.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000273352; ENSP00000273352; ENSG00000144820.
GeneIDi84873.
KEGGihsa:84873.
UCSCiuc003duc.5. human.

Organism-specific databases

CTDi84873.
DisGeNETi84873.
GeneCardsiADGRG7.
HGNCiHGNC:19241. ADGRG7.
HPAiHPA021135.
MIMi612307. gene.
neXtProtiNX_Q96K78.
OpenTargetsiENSG00000144820.
PharmGKBiPA134982718.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4193. Eukaryota.
ENOG410XSD2. LUCA.
GeneTreeiENSGT00830000128272.
HOGENOMiHOG000236310.
HOVERGENiHBG063831.
InParanoidiQ96K78.
KOiK08464.
OMAiCICTEEW.
OrthoDBiEOG091G03DK.
PhylomeDBiQ96K78.
TreeFamiTF351485.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000144820-MONOMER.

Miscellaneous databases

ChiTaRSiGPR128. human.
GenomeRNAii84873.
PROiQ96K78.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000144820.
CleanExiHS_GPR128.
ExpressionAtlasiQ96K78. baseline and differential.
GenevisibleiQ96K78. HS.

Family and domain databases

InterProiIPR017981. GPCR_2-like.
IPR000832. GPCR_2_secretin-like.
IPR000203. GPS.
[Graphical view]
PfamiPF00002. 7tm_2. 1 hit.
PF01825. GPS. 1 hit.
[Graphical view]
PRINTSiPR00249. GPCRSECRETIN.
SMARTiSM00303. GPS. 1 hit.
[Graphical view]
PROSITEiPS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
PS50221. GPS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAGRG7_HUMAN
AccessioniPrimary (citable) accession number: Q96K78
Secondary accession number(s): Q14D94, Q86SQ2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 29, 2004
Last sequence update: May 5, 2009
Last modified: November 30, 2016
This is version 124 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.