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Q96K78 (GP128_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 92. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable G-protein coupled receptor 128
Gene names
Name:GPR128
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length797 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Orphan receptor.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.

Contains 1 GPS domain.

Sequence caution

The sequence AAO27358.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Cellular componentCell membrane
Membrane
   Coding sequence diversityPolymorphism
   DomainSignal
Transmembrane
Transmembrane helix
   Molecular functionG-protein coupled receptor
Receptor
Transducer
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processneuropeptide signaling pathway

Inferred from electronic annotation. Source: InterPro

   Cellular_componentintegral to membrane

Traceable author statement PubMed 15203201. Source: GDB

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionG-protein coupled receptor activity

Traceable author statement PubMed 15203201. Source: GDB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2626 Potential
Chain27 – 797771Probable G-protein coupled receptor 128
PRO_0000012903

Regions

Topological domain27 – 438412Extracellular Potential
Transmembrane439 – 45921Helical; Name=1; Potential
Topological domain460 – 4689Cytoplasmic Potential
Transmembrane469 – 48921Helical; Name=2; Potential
Topological domain490 – 52839Extracellular Potential
Transmembrane529 – 54921Helical; Name=3; Potential
Topological domain550 – 56516Cytoplasmic Potential
Transmembrane566 – 58621Helical; Name=4; Potential
Topological domain587 – 62337Extracellular Potential
Transmembrane624 – 64421Helical; Name=5; Potential
Topological domain645 – 66925Cytoplasmic Potential
Transmembrane670 – 69021Helical; Name=6; Potential
Topological domain691 – 6988Extracellular Potential
Transmembrane699 – 71921Helical; Name=7; Potential
Topological domain720 – 79778Cytoplasmic Potential
Domain380 – 42748GPS

Amino acid modifications

Glycosylation821N-linked (GlcNAc...) Potential
Glycosylation1591N-linked (GlcNAc...) Potential
Glycosylation1781N-linked (GlcNAc...) Potential
Glycosylation1911N-linked (GlcNAc...) Potential
Glycosylation2471N-linked (GlcNAc...) Potential
Glycosylation2611N-linked (GlcNAc...) Potential
Glycosylation3121N-linked (GlcNAc...) Potential
Glycosylation3161N-linked (GlcNAc...) Potential
Glycosylation3871N-linked (GlcNAc...) Potential
Glycosylation4131N-linked (GlcNAc...) Potential

Natural variations

Natural variant1511K → E. Ref.2
Corresponds to variant rs1144122 [ dbSNP | Ensembl ].
VAR_055138
Natural variant6451T → S.
Corresponds to variant rs16842529 [ dbSNP | Ensembl ].
VAR_049459
Natural variant7561R → H.
Corresponds to variant rs9872512 [ dbSNP | Ensembl ].
VAR_049460

Sequences

Sequence LengthMass (Da)Tools
Q96K78 [UniParc].

Last modified May 5, 2009. Version 2.
Checksum: D6CAAA78AC0E4679

FASTA79788,909
        10         20         30         40         50         60 
MASCRAWNLR VLVAVVCGLL TGIILGLGIW RIVIRIQRGK STSSSSTPTE FCRNGGTWEN 

        70         80         90        100        110        120 
GRCICTEEWK GLRCTIANFC ENSTYMGFTF ARIPVGRYGP SLQTCGKDTP NAGNPMAVRL 

       130        140        150        160        170        180 
CSLSLYGEIE LQKVTIGNCN ENLETLEKQV KDVTAPLNNI SSEVQILTSD ANKLTAENIT 

       190        200        210        220        230        240 
SATRVVGQIF NTSRNASPEA KKVAIVTVSQ LLDASEDAFQ RVAATANDDA LTTLIEQMET 

       250        260        270        280        290        300 
YSLSLGNQSV VEPNIAIQSA NFSSENAVGP SNVRFSVQKG ASSSLVSSST FIHTNVDGLN 

       310        320        330        340        350        360 
PDAQTELQVL LNMTKNYTKT CGFVVYQNDK LFQSKTFTAK SDFSQKIISS KTDENEQDQS 

       370        380        390        400        410        420 
ASVDMVFSPK YNQKEFQLYS YACVYWNLSA KDWDTYGCQK DKGTDGFLRC RCNHTTNFAV 

       430        440        450        460        470        480 
LMTFKKDYQY PKSLDILSNV GCALSVTGLA LTVIFQIVTR KVRKTSVTWV LVNLCISMLI 

       490        500        510        520        530        540 
FNLLFVFGIE NSNKNLQTSD GDINNIDFDN NDIPRTDTIN IPNPMCTAIA ALLHYFLLVT 

       550        560        570        580        590        600 
FTWNALSAAQ LYYLLIRTMK PLPRHFILFI SLIGWGVPAI VVAITVGVIY SQNGNNPQWE 

       610        620        630        640        650        660 
LDYRQEKICW LAIPEPNGVI KSPLLWSFIV PVTIILISNV VMFITISIKV LWKNNQNLTS 

       670        680        690        700        710        720 
TKKVSSMKKI VSTLSVAVVF GITWILAYLM LVNDDSIRIV FSYIFCLFNT TQGLQIFILY 

       730        740        750        760        770        780 
TVRTKVFQSE ASKVLMLLSS IGRRKSLPSV TRPRLRVKMY NFLRSLPTLH ERFRLLETSP 

       790 
STEEITLSES DNAKESI

« Hide

References

« Hide 'large scale' references
[1]"There exist at least 30 human G-protein-coupled receptors with long Ser/Thr-rich N-termini."
Fredriksson R., Gloriam D.E.I., Hoeglund P.J., Lagerstroem M.C., Schioeth H.B.
Biochem. Biophys. Res. Commun. 301:725-734(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT GLU-151.
Tissue: Embryo.
[3]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AY181246 mRNA. Translation: AAO27358.1. Different initiation.
AK027360 mRNA. Translation: BAB55061.1.
CH471052 Genomic DNA. Translation: EAW79818.1.
BC113451 mRNA. Translation: AAI13452.1.
IPIIPI00064461.
RefSeqNP_116176.2. NM_032787.2.
UniGeneHs.334511.

3D structure databases

ProteinModelPortalQ96K78.
ModBaseSearch...

Protein-protein interaction databases

STRING9606.ENSP00000273352.

Protein family/group databases

MEROPSS63.023.
GPCRDBSearch...

PTM databases

PhosphoSiteQ96K78.

Polymorphism databases

DMDM229462926.

Proteomic databases

PaxDbQ96K78.
PRIDEQ96K78.

Protocols and materials databases

DNASU84873.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000273352; ENSP00000273352; ENSG00000144820.
GeneID84873.
KEGGhsa:84873.
UCSCuc003duc.3. human.

Organism-specific databases

CTD84873.
GeneCardsGC03P100328.
HGNCHGNC:19241. GPR128.
HPAHPA021135.
MIM612307. gene.
neXtProtNX_Q96K78.
PharmGKBPA134982718.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG271406.
HOGENOMHOG000236310.
HOVERGENHBG063831.
InParanoidQ96K78.
KOK08464.
OMAQWELDYR.
OrthoDBEOG4PC9RG.
PhylomeDBQ96K78.

Gene expression databases

ArrayExpressQ96K78.
BgeeQ96K78.
CleanExHS_GPR128.
GenevestigatorQ96K78.
GermOnlineENSG00000144820. Homo sapiens.

Family and domain databases

InterProIPR017981. GPCR_2-like.
IPR000832. GPCR_2_secretin-like.
IPR000203. GPS_dom.
[Graphical view]
PfamPF00002. 7tm_2. 1 hit.
PF01825. GPS. 1 hit.
[Graphical view]
PRINTSPR00249. GPCRSECRETIN.
SMARTSM00303. GPS. 1 hit.
[Graphical view]
PROSITEPS00650. G_PROTEIN_RECEP_F2_2. False negative.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
PS50221. GPS. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSGPR128. human.
GenomeRNAi84873.
NextBio75167.
SOURCESearch...

Entry information

Entry nameGP128_HUMAN
AccessionPrimary (citable) accession number: Q96K78
Secondary accession number(s): Q14D94, Q86SQ2
Entry history
Integrated into UniProtKB/Swiss-Prot: March 29, 2004
Last sequence update: May 5, 2009
Last modified: May 1, 2013
This is version 92 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries

Human chromosome 3

Human chromosome 3: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents