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Q96K78

- GP128_HUMAN

UniProt

Q96K78 - GP128_HUMAN

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Protein
Probable G-protein coupled receptor 128
Gene
GPR128
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Orphan receptor.

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: GDB

GO - Biological processi

  1. G-protein coupled receptor signaling pathway Source: GDB
  2. neuropeptide signaling pathway Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Protein family/group databases

MEROPSiS63.023.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable G-protein coupled receptor 128
Gene namesi
Name:GPR128
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 3

Organism-specific databases

HGNCiHGNC:19241. GPR128.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini27 – 438412Extracellular Reviewed prediction
Add
BLAST
Transmembranei439 – 45921Helical; Name=1; Reviewed prediction
Add
BLAST
Topological domaini460 – 4689Cytoplasmic Reviewed prediction
Transmembranei469 – 48921Helical; Name=2; Reviewed prediction
Add
BLAST
Topological domaini490 – 52839Extracellular Reviewed prediction
Add
BLAST
Transmembranei529 – 54921Helical; Name=3; Reviewed prediction
Add
BLAST
Topological domaini550 – 56516Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei566 – 58621Helical; Name=4; Reviewed prediction
Add
BLAST
Topological domaini587 – 62337Extracellular Reviewed prediction
Add
BLAST
Transmembranei624 – 64421Helical; Name=5; Reviewed prediction
Add
BLAST
Topological domaini645 – 66925Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei670 – 69021Helical; Name=6; Reviewed prediction
Add
BLAST
Topological domaini691 – 6988Extracellular Reviewed prediction
Transmembranei699 – 71921Helical; Name=7; Reviewed prediction
Add
BLAST
Topological domaini720 – 79778Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: GDB
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134982718.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626 Reviewed prediction
Add
BLAST
Chaini27 – 797771Probable G-protein coupled receptor 128
PRO_0000012903Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi82 – 821N-linked (GlcNAc...) Reviewed prediction
Glycosylationi159 – 1591N-linked (GlcNAc...) Reviewed prediction
Glycosylationi178 – 1781N-linked (GlcNAc...) Reviewed prediction
Glycosylationi191 – 1911N-linked (GlcNAc...) Reviewed prediction
Glycosylationi247 – 2471N-linked (GlcNAc...) Reviewed prediction
Glycosylationi261 – 2611N-linked (GlcNAc...) Reviewed prediction
Glycosylationi312 – 3121N-linked (GlcNAc...) Reviewed prediction
Glycosylationi316 – 3161N-linked (GlcNAc...) Reviewed prediction
Glycosylationi387 – 3871N-linked (GlcNAc...) Reviewed prediction
Glycosylationi413 – 4131N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ96K78.
PRIDEiQ96K78.

PTM databases

PhosphoSiteiQ96K78.

Expressioni

Gene expression databases

ArrayExpressiQ96K78.
BgeeiQ96K78.
CleanExiHS_GPR128.
GenevestigatoriQ96K78.

Organism-specific databases

HPAiHPA021135.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000273352.

Structurei

3D structure databases

ProteinModelPortaliQ96K78.
SMRiQ96K78. Positions 50-75, 526-714.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini380 – 42748GPS
Add
BLAST

Sequence similaritiesi

Contains 1 GPS domain.

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG271406.
HOGENOMiHOG000236310.
HOVERGENiHBG063831.
InParanoidiQ96K78.
KOiK08464.
OMAiCICTEEW.
OrthoDBiEOG7NW68G.
PhylomeDBiQ96K78.
TreeFamiTF351485.

Family and domain databases

InterProiIPR017981. GPCR_2-like.
IPR000832. GPCR_2_secretin-like.
IPR000203. GPS.
[Graphical view]
PfamiPF00002. 7tm_2. 1 hit.
PF01825. GPS. 1 hit.
[Graphical view]
PRINTSiPR00249. GPCRSECRETIN.
SMARTiSM00303. GPS. 1 hit.
[Graphical view]
PROSITEiPS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
PS50221. GPS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q96K78-1 [UniParc]FASTAAdd to Basket

« Hide

MASCRAWNLR VLVAVVCGLL TGIILGLGIW RIVIRIQRGK STSSSSTPTE    50
FCRNGGTWEN GRCICTEEWK GLRCTIANFC ENSTYMGFTF ARIPVGRYGP 100
SLQTCGKDTP NAGNPMAVRL CSLSLYGEIE LQKVTIGNCN ENLETLEKQV 150
KDVTAPLNNI SSEVQILTSD ANKLTAENIT SATRVVGQIF NTSRNASPEA 200
KKVAIVTVSQ LLDASEDAFQ RVAATANDDA LTTLIEQMET YSLSLGNQSV 250
VEPNIAIQSA NFSSENAVGP SNVRFSVQKG ASSSLVSSST FIHTNVDGLN 300
PDAQTELQVL LNMTKNYTKT CGFVVYQNDK LFQSKTFTAK SDFSQKIISS 350
KTDENEQDQS ASVDMVFSPK YNQKEFQLYS YACVYWNLSA KDWDTYGCQK 400
DKGTDGFLRC RCNHTTNFAV LMTFKKDYQY PKSLDILSNV GCALSVTGLA 450
LTVIFQIVTR KVRKTSVTWV LVNLCISMLI FNLLFVFGIE NSNKNLQTSD 500
GDINNIDFDN NDIPRTDTIN IPNPMCTAIA ALLHYFLLVT FTWNALSAAQ 550
LYYLLIRTMK PLPRHFILFI SLIGWGVPAI VVAITVGVIY SQNGNNPQWE 600
LDYRQEKICW LAIPEPNGVI KSPLLWSFIV PVTIILISNV VMFITISIKV 650
LWKNNQNLTS TKKVSSMKKI VSTLSVAVVF GITWILAYLM LVNDDSIRIV 700
FSYIFCLFNT TQGLQIFILY TVRTKVFQSE ASKVLMLLSS IGRRKSLPSV 750
TRPRLRVKMY NFLRSLPTLH ERFRLLETSP STEEITLSES DNAKESI 797
Length:797
Mass (Da):88,909
Last modified:May 5, 2009 - v2
Checksum:iD6CAAA78AC0E4679
GO

Sequence cautioni

The sequence AAO27358.1 differs from that shown. Reason: Erroneous initiation.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti151 – 1511K → E.1 Publication
Corresponds to variant rs1144122 [ dbSNP | Ensembl ].
VAR_055138
Natural varianti645 – 6451T → S.
Corresponds to variant rs16842529 [ dbSNP | Ensembl ].
VAR_049459
Natural varianti756 – 7561R → H.
Corresponds to variant rs9872512 [ dbSNP | Ensembl ].
VAR_049460

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY181246 mRNA. Translation: AAO27358.1. Different initiation.
AK027360 mRNA. Translation: BAB55061.1.
CH471052 Genomic DNA. Translation: EAW79818.1.
BC113451 mRNA. Translation: AAI13452.1.
CCDSiCCDS2938.1.
RefSeqiNP_116176.2. NM_032787.2.
UniGeneiHs.334511.

Genome annotation databases

EnsembliENST00000273352; ENSP00000273352; ENSG00000144820.
GeneIDi84873.
KEGGihsa:84873.
UCSCiuc003duc.3. human.

Polymorphism databases

DMDMi229462926.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY181246 mRNA. Translation: AAO27358.1 . Different initiation.
AK027360 mRNA. Translation: BAB55061.1 .
CH471052 Genomic DNA. Translation: EAW79818.1 .
BC113451 mRNA. Translation: AAI13452.1 .
CCDSi CCDS2938.1.
RefSeqi NP_116176.2. NM_032787.2.
UniGenei Hs.334511.

3D structure databases

ProteinModelPortali Q96K78.
SMRi Q96K78. Positions 50-75, 526-714.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000273352.

Protein family/group databases

MEROPSi S63.023.
GPCRDBi Search...

PTM databases

PhosphoSitei Q96K78.

Polymorphism databases

DMDMi 229462926.

Proteomic databases

PaxDbi Q96K78.
PRIDEi Q96K78.

Protocols and materials databases

DNASUi 84873.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000273352 ; ENSP00000273352 ; ENSG00000144820 .
GeneIDi 84873.
KEGGi hsa:84873.
UCSCi uc003duc.3. human.

Organism-specific databases

CTDi 84873.
GeneCardsi GC03P100328.
HGNCi HGNC:19241. GPR128.
HPAi HPA021135.
MIMi 612307. gene.
neXtProti NX_Q96K78.
PharmGKBi PA134982718.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG271406.
HOGENOMi HOG000236310.
HOVERGENi HBG063831.
InParanoidi Q96K78.
KOi K08464.
OMAi CICTEEW.
OrthoDBi EOG7NW68G.
PhylomeDBi Q96K78.
TreeFami TF351485.

Miscellaneous databases

ChiTaRSi GPR128. human.
GenomeRNAii 84873.
NextBioi 75167.
PROi Q96K78.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q96K78.
Bgeei Q96K78.
CleanExi HS_GPR128.
Genevestigatori Q96K78.

Family and domain databases

InterProi IPR017981. GPCR_2-like.
IPR000832. GPCR_2_secretin-like.
IPR000203. GPS.
[Graphical view ]
Pfami PF00002. 7tm_2. 1 hit.
PF01825. GPS. 1 hit.
[Graphical view ]
PRINTSi PR00249. GPCRSECRETIN.
SMARTi SM00303. GPS. 1 hit.
[Graphical view ]
PROSITEi PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
PS50221. GPS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "There exist at least 30 human G-protein-coupled receptors with long Ser/Thr-rich N-termini."
    Fredriksson R., Gloriam D.E.I., Hoeglund P.J., Lagerstroem M.C., Schioeth H.B.
    Biochem. Biophys. Res. Commun. 301:725-734(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT GLU-151.
    Tissue: Embryo.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiGP128_HUMAN
AccessioniPrimary (citable) accession number: Q96K78
Secondary accession number(s): Q14D94, Q86SQ2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 29, 2004
Last sequence update: May 5, 2009
Last modified: July 9, 2014
This is version 102 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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