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Q96K78

- GP128_HUMAN

UniProt

Q96K78 - GP128_HUMAN

Protein

Probable G-protein coupled receptor 128

Gene

GPR128

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 103 (01 Oct 2014)
      Sequence version 2 (05 May 2009)
      Previous versions | rss
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    Functioni

    Orphan receptor.

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: GDB

    GO - Biological processi

    1. G-protein coupled receptor signaling pathway Source: GDB
    2. neuropeptide signaling pathway Source: InterPro

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Protein family/group databases

    MEROPSiS63.023.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable G-protein coupled receptor 128
    Gene namesi
    Name:GPR128
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 3

    Organism-specific databases

    HGNCiHGNC:19241. GPR128.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: GDB
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134982718.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2626Sequence AnalysisAdd
    BLAST
    Chaini27 – 797771Probable G-protein coupled receptor 128PRO_0000012903Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi82 – 821N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi159 – 1591N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi178 – 1781N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi191 – 1911N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi247 – 2471N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi261 – 2611N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi312 – 3121N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi316 – 3161N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi387 – 3871N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi413 – 4131N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ96K78.
    PRIDEiQ96K78.

    PTM databases

    PhosphoSiteiQ96K78.

    Expressioni

    Gene expression databases

    ArrayExpressiQ96K78.
    BgeeiQ96K78.
    CleanExiHS_GPR128.
    GenevestigatoriQ96K78.

    Organism-specific databases

    HPAiHPA021135.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000273352.

    Structurei

    3D structure databases

    ProteinModelPortaliQ96K78.
    SMRiQ96K78. Positions 50-75, 526-714.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini27 – 438412ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini460 – 4689CytoplasmicSequence Analysis
    Topological domaini490 – 52839ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini550 – 56516CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini587 – 62337ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini645 – 66925CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini691 – 6988ExtracellularSequence Analysis
    Topological domaini720 – 79778CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei439 – 45921Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei469 – 48921Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei529 – 54921Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei566 – 58621Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei624 – 64421Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei670 – 69021Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei699 – 71921Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini380 – 42748GPSPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 GPS domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG271406.
    HOGENOMiHOG000236310.
    HOVERGENiHBG063831.
    InParanoidiQ96K78.
    KOiK08464.
    OMAiCICTEEW.
    OrthoDBiEOG7NW68G.
    PhylomeDBiQ96K78.
    TreeFamiTF351485.

    Family and domain databases

    InterProiIPR017981. GPCR_2-like.
    IPR000832. GPCR_2_secretin-like.
    IPR000203. GPS.
    [Graphical view]
    PfamiPF00002. 7tm_2. 1 hit.
    PF01825. GPS. 1 hit.
    [Graphical view]
    PRINTSiPR00249. GPCRSECRETIN.
    SMARTiSM00303. GPS. 1 hit.
    [Graphical view]
    PROSITEiPS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
    PS50221. GPS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q96K78-1 [UniParc]FASTAAdd to Basket

    « Hide

    MASCRAWNLR VLVAVVCGLL TGIILGLGIW RIVIRIQRGK STSSSSTPTE    50
    FCRNGGTWEN GRCICTEEWK GLRCTIANFC ENSTYMGFTF ARIPVGRYGP 100
    SLQTCGKDTP NAGNPMAVRL CSLSLYGEIE LQKVTIGNCN ENLETLEKQV 150
    KDVTAPLNNI SSEVQILTSD ANKLTAENIT SATRVVGQIF NTSRNASPEA 200
    KKVAIVTVSQ LLDASEDAFQ RVAATANDDA LTTLIEQMET YSLSLGNQSV 250
    VEPNIAIQSA NFSSENAVGP SNVRFSVQKG ASSSLVSSST FIHTNVDGLN 300
    PDAQTELQVL LNMTKNYTKT CGFVVYQNDK LFQSKTFTAK SDFSQKIISS 350
    KTDENEQDQS ASVDMVFSPK YNQKEFQLYS YACVYWNLSA KDWDTYGCQK 400
    DKGTDGFLRC RCNHTTNFAV LMTFKKDYQY PKSLDILSNV GCALSVTGLA 450
    LTVIFQIVTR KVRKTSVTWV LVNLCISMLI FNLLFVFGIE NSNKNLQTSD 500
    GDINNIDFDN NDIPRTDTIN IPNPMCTAIA ALLHYFLLVT FTWNALSAAQ 550
    LYYLLIRTMK PLPRHFILFI SLIGWGVPAI VVAITVGVIY SQNGNNPQWE 600
    LDYRQEKICW LAIPEPNGVI KSPLLWSFIV PVTIILISNV VMFITISIKV 650
    LWKNNQNLTS TKKVSSMKKI VSTLSVAVVF GITWILAYLM LVNDDSIRIV 700
    FSYIFCLFNT TQGLQIFILY TVRTKVFQSE ASKVLMLLSS IGRRKSLPSV 750
    TRPRLRVKMY NFLRSLPTLH ERFRLLETSP STEEITLSES DNAKESI 797
    Length:797
    Mass (Da):88,909
    Last modified:May 5, 2009 - v2
    Checksum:iD6CAAA78AC0E4679
    GO

    Sequence cautioni

    The sequence AAO27358.1 differs from that shown. Reason: Erroneous initiation.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti151 – 1511K → E.1 Publication
    Corresponds to variant rs1144122 [ dbSNP | Ensembl ].
    VAR_055138
    Natural varianti645 – 6451T → S.
    Corresponds to variant rs16842529 [ dbSNP | Ensembl ].
    VAR_049459
    Natural varianti756 – 7561R → H.
    Corresponds to variant rs9872512 [ dbSNP | Ensembl ].
    VAR_049460

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY181246 mRNA. Translation: AAO27358.1. Different initiation.
    AK027360 mRNA. Translation: BAB55061.1.
    CH471052 Genomic DNA. Translation: EAW79818.1.
    BC113451 mRNA. Translation: AAI13452.1.
    CCDSiCCDS2938.1.
    RefSeqiNP_116176.2. NM_032787.2.
    UniGeneiHs.334511.

    Genome annotation databases

    EnsembliENST00000273352; ENSP00000273352; ENSG00000144820.
    GeneIDi84873.
    KEGGihsa:84873.
    UCSCiuc003duc.3. human.

    Polymorphism databases

    DMDMi229462926.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY181246 mRNA. Translation: AAO27358.1 . Different initiation.
    AK027360 mRNA. Translation: BAB55061.1 .
    CH471052 Genomic DNA. Translation: EAW79818.1 .
    BC113451 mRNA. Translation: AAI13452.1 .
    CCDSi CCDS2938.1.
    RefSeqi NP_116176.2. NM_032787.2.
    UniGenei Hs.334511.

    3D structure databases

    ProteinModelPortali Q96K78.
    SMRi Q96K78. Positions 50-75, 526-714.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000273352.

    Protein family/group databases

    MEROPSi S63.023.
    GPCRDBi Search...

    PTM databases

    PhosphoSitei Q96K78.

    Polymorphism databases

    DMDMi 229462926.

    Proteomic databases

    PaxDbi Q96K78.
    PRIDEi Q96K78.

    Protocols and materials databases

    DNASUi 84873.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000273352 ; ENSP00000273352 ; ENSG00000144820 .
    GeneIDi 84873.
    KEGGi hsa:84873.
    UCSCi uc003duc.3. human.

    Organism-specific databases

    CTDi 84873.
    GeneCardsi GC03P100328.
    HGNCi HGNC:19241. GPR128.
    HPAi HPA021135.
    MIMi 612307. gene.
    neXtProti NX_Q96K78.
    PharmGKBi PA134982718.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG271406.
    HOGENOMi HOG000236310.
    HOVERGENi HBG063831.
    InParanoidi Q96K78.
    KOi K08464.
    OMAi CICTEEW.
    OrthoDBi EOG7NW68G.
    PhylomeDBi Q96K78.
    TreeFami TF351485.

    Miscellaneous databases

    ChiTaRSi GPR128. human.
    GenomeRNAii 84873.
    NextBioi 75167.
    PROi Q96K78.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q96K78.
    Bgeei Q96K78.
    CleanExi HS_GPR128.
    Genevestigatori Q96K78.

    Family and domain databases

    InterProi IPR017981. GPCR_2-like.
    IPR000832. GPCR_2_secretin-like.
    IPR000203. GPS.
    [Graphical view ]
    Pfami PF00002. 7tm_2. 1 hit.
    PF01825. GPS. 1 hit.
    [Graphical view ]
    PRINTSi PR00249. GPCRSECRETIN.
    SMARTi SM00303. GPS. 1 hit.
    [Graphical view ]
    PROSITEi PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
    PS50221. GPS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "There exist at least 30 human G-protein-coupled receptors with long Ser/Thr-rich N-termini."
      Fredriksson R., Gloriam D.E.I., Hoeglund P.J., Lagerstroem M.C., Schioeth H.B.
      Biochem. Biophys. Res. Commun. 301:725-734(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT GLU-151.
      Tissue: Embryo.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

    Entry informationi

    Entry nameiGP128_HUMAN
    AccessioniPrimary (citable) accession number: Q96K78
    Secondary accession number(s): Q14D94, Q86SQ2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 29, 2004
    Last sequence update: May 5, 2009
    Last modified: October 1, 2014
    This is version 103 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 3
      Human chromosome 3: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3