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Q96K78

- GP128_HUMAN

UniProt

Q96K78 - GP128_HUMAN

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Protein

Probable G-protein coupled receptor 128

Gene

GPR128

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Orphan receptor.

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: GDB

GO - Biological processi

  1. G-protein coupled receptor signaling pathway Source: GDB
  2. neuropeptide signaling pathway Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Protein family/group databases

MEROPSiS63.023.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable G-protein coupled receptor 128
Gene namesi
Name:GPR128
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 3

Organism-specific databases

HGNCiHGNC:19241. GPR128.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: GDB
  2. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134982718.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626Sequence AnalysisAdd
BLAST
Chaini27 – 797771Probable G-protein coupled receptor 128PRO_0000012903Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi82 – 821N-linked (GlcNAc...)Sequence Analysis
Glycosylationi159 – 1591N-linked (GlcNAc...)Sequence Analysis
Glycosylationi178 – 1781N-linked (GlcNAc...)Sequence Analysis
Glycosylationi191 – 1911N-linked (GlcNAc...)Sequence Analysis
Glycosylationi247 – 2471N-linked (GlcNAc...)Sequence Analysis
Glycosylationi261 – 2611N-linked (GlcNAc...)Sequence Analysis
Glycosylationi312 – 3121N-linked (GlcNAc...)Sequence Analysis
Glycosylationi316 – 3161N-linked (GlcNAc...)Sequence Analysis
Glycosylationi387 – 3871N-linked (GlcNAc...)Sequence Analysis
Glycosylationi413 – 4131N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ96K78.
PRIDEiQ96K78.

PTM databases

PhosphoSiteiQ96K78.

Expressioni

Gene expression databases

BgeeiQ96K78.
CleanExiHS_GPR128.
ExpressionAtlasiQ96K78. baseline and differential.
GenevestigatoriQ96K78.

Organism-specific databases

HPAiHPA021135.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000273352.

Structurei

3D structure databases

ProteinModelPortaliQ96K78.
SMRiQ96K78. Positions 526-714.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini27 – 438412ExtracellularSequence AnalysisAdd
BLAST
Topological domaini460 – 4689CytoplasmicSequence Analysis
Topological domaini490 – 52839ExtracellularSequence AnalysisAdd
BLAST
Topological domaini550 – 56516CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini587 – 62337ExtracellularSequence AnalysisAdd
BLAST
Topological domaini645 – 66925CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini691 – 6988ExtracellularSequence Analysis
Topological domaini720 – 79778CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei439 – 45921Helical; Name=1Sequence AnalysisAdd
BLAST
Transmembranei469 – 48921Helical; Name=2Sequence AnalysisAdd
BLAST
Transmembranei529 – 54921Helical; Name=3Sequence AnalysisAdd
BLAST
Transmembranei566 – 58621Helical; Name=4Sequence AnalysisAdd
BLAST
Transmembranei624 – 64421Helical; Name=5Sequence AnalysisAdd
BLAST
Transmembranei670 – 69021Helical; Name=6Sequence AnalysisAdd
BLAST
Transmembranei699 – 71921Helical; Name=7Sequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini380 – 42748GPSPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 GPS domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG271406.
GeneTreeiENSGT00610000085899.
HOGENOMiHOG000236310.
HOVERGENiHBG063831.
InParanoidiQ96K78.
KOiK08464.
OMAiCICTEEW.
OrthoDBiEOG7NW68G.
PhylomeDBiQ96K78.
TreeFamiTF351485.

Family and domain databases

InterProiIPR017981. GPCR_2-like.
IPR000832. GPCR_2_secretin-like.
IPR000203. GPS.
[Graphical view]
PfamiPF00002. 7tm_2. 1 hit.
PF01825. GPS. 1 hit.
[Graphical view]
PRINTSiPR00249. GPCRSECRETIN.
SMARTiSM00303. GPS. 1 hit.
[Graphical view]
PROSITEiPS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
PS50221. GPS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q96K78-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MASCRAWNLR VLVAVVCGLL TGIILGLGIW RIVIRIQRGK STSSSSTPTE
60 70 80 90 100
FCRNGGTWEN GRCICTEEWK GLRCTIANFC ENSTYMGFTF ARIPVGRYGP
110 120 130 140 150
SLQTCGKDTP NAGNPMAVRL CSLSLYGEIE LQKVTIGNCN ENLETLEKQV
160 170 180 190 200
KDVTAPLNNI SSEVQILTSD ANKLTAENIT SATRVVGQIF NTSRNASPEA
210 220 230 240 250
KKVAIVTVSQ LLDASEDAFQ RVAATANDDA LTTLIEQMET YSLSLGNQSV
260 270 280 290 300
VEPNIAIQSA NFSSENAVGP SNVRFSVQKG ASSSLVSSST FIHTNVDGLN
310 320 330 340 350
PDAQTELQVL LNMTKNYTKT CGFVVYQNDK LFQSKTFTAK SDFSQKIISS
360 370 380 390 400
KTDENEQDQS ASVDMVFSPK YNQKEFQLYS YACVYWNLSA KDWDTYGCQK
410 420 430 440 450
DKGTDGFLRC RCNHTTNFAV LMTFKKDYQY PKSLDILSNV GCALSVTGLA
460 470 480 490 500
LTVIFQIVTR KVRKTSVTWV LVNLCISMLI FNLLFVFGIE NSNKNLQTSD
510 520 530 540 550
GDINNIDFDN NDIPRTDTIN IPNPMCTAIA ALLHYFLLVT FTWNALSAAQ
560 570 580 590 600
LYYLLIRTMK PLPRHFILFI SLIGWGVPAI VVAITVGVIY SQNGNNPQWE
610 620 630 640 650
LDYRQEKICW LAIPEPNGVI KSPLLWSFIV PVTIILISNV VMFITISIKV
660 670 680 690 700
LWKNNQNLTS TKKVSSMKKI VSTLSVAVVF GITWILAYLM LVNDDSIRIV
710 720 730 740 750
FSYIFCLFNT TQGLQIFILY TVRTKVFQSE ASKVLMLLSS IGRRKSLPSV
760 770 780 790
TRPRLRVKMY NFLRSLPTLH ERFRLLETSP STEEITLSES DNAKESI
Length:797
Mass (Da):88,909
Last modified:May 5, 2009 - v2
Checksum:iD6CAAA78AC0E4679
GO

Sequence cautioni

The sequence AAO27358.1 differs from that shown. Reason: Erroneous initiation.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti151 – 1511K → E.1 Publication
Corresponds to variant rs1144122 [ dbSNP | Ensembl ].
VAR_055138
Natural varianti645 – 6451T → S.
Corresponds to variant rs16842529 [ dbSNP | Ensembl ].
VAR_049459
Natural varianti756 – 7561R → H.
Corresponds to variant rs9872512 [ dbSNP | Ensembl ].
VAR_049460

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY181246 mRNA. Translation: AAO27358.1. Different initiation.
AK027360 mRNA. Translation: BAB55061.1.
CH471052 Genomic DNA. Translation: EAW79818.1.
BC113451 mRNA. Translation: AAI13452.1.
CCDSiCCDS2938.1.
RefSeqiNP_116176.2. NM_032787.2.
UniGeneiHs.334511.

Genome annotation databases

EnsembliENST00000273352; ENSP00000273352; ENSG00000144820.
GeneIDi84873.
KEGGihsa:84873.
UCSCiuc003duc.3. human.

Polymorphism databases

DMDMi229462926.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY181246 mRNA. Translation: AAO27358.1 . Different initiation.
AK027360 mRNA. Translation: BAB55061.1 .
CH471052 Genomic DNA. Translation: EAW79818.1 .
BC113451 mRNA. Translation: AAI13452.1 .
CCDSi CCDS2938.1.
RefSeqi NP_116176.2. NM_032787.2.
UniGenei Hs.334511.

3D structure databases

ProteinModelPortali Q96K78.
SMRi Q96K78. Positions 526-714.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000273352.

Protein family/group databases

MEROPSi S63.023.
GPCRDBi Search...

PTM databases

PhosphoSitei Q96K78.

Polymorphism databases

DMDMi 229462926.

Proteomic databases

PaxDbi Q96K78.
PRIDEi Q96K78.

Protocols and materials databases

DNASUi 84873.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000273352 ; ENSP00000273352 ; ENSG00000144820 .
GeneIDi 84873.
KEGGi hsa:84873.
UCSCi uc003duc.3. human.

Organism-specific databases

CTDi 84873.
GeneCardsi GC03P100328.
HGNCi HGNC:19241. GPR128.
HPAi HPA021135.
MIMi 612307. gene.
neXtProti NX_Q96K78.
PharmGKBi PA134982718.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG271406.
GeneTreei ENSGT00610000085899.
HOGENOMi HOG000236310.
HOVERGENi HBG063831.
InParanoidi Q96K78.
KOi K08464.
OMAi CICTEEW.
OrthoDBi EOG7NW68G.
PhylomeDBi Q96K78.
TreeFami TF351485.

Miscellaneous databases

ChiTaRSi GPR128. human.
GenomeRNAii 84873.
NextBioi 75167.
PROi Q96K78.
SOURCEi Search...

Gene expression databases

Bgeei Q96K78.
CleanExi HS_GPR128.
ExpressionAtlasi Q96K78. baseline and differential.
Genevestigatori Q96K78.

Family and domain databases

InterProi IPR017981. GPCR_2-like.
IPR000832. GPCR_2_secretin-like.
IPR000203. GPS.
[Graphical view ]
Pfami PF00002. 7tm_2. 1 hit.
PF01825. GPS. 1 hit.
[Graphical view ]
PRINTSi PR00249. GPCRSECRETIN.
SMARTi SM00303. GPS. 1 hit.
[Graphical view ]
PROSITEi PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
PS50221. GPS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "There exist at least 30 human G-protein-coupled receptors with long Ser/Thr-rich N-termini."
    Fredriksson R., Gloriam D.E.I., Hoeglund P.J., Lagerstroem M.C., Schioeth H.B.
    Biochem. Biophys. Res. Commun. 301:725-734(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT GLU-151.
    Tissue: Embryo.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiGP128_HUMAN
AccessioniPrimary (citable) accession number: Q96K78
Secondary accession number(s): Q14D94, Q86SQ2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 29, 2004
Last sequence update: May 5, 2009
Last modified: October 29, 2014
This is version 104 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3