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Q96K76

- UBP47_HUMAN

UniProt

Q96K76 - UBP47_HUMAN

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Protein
Ubiquitin carboxyl-terminal hydrolase 47
Gene
USP47
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Ubiquitin-specific protease that specifically deubiquitinates monoubiquitinated DNA polymerase beta (POLB), stabilizing POLB thereby playing a role in base-excision repair (BER). Acts as a regulator of cell growth and genome integrity. May also indirectly regulates CDC25A expression at a transcriptional level.2 Publications

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei197 – 1971Nucleophile By similarity
Active sitei503 – 5031Proton acceptor By similarity

GO - Molecular functioni

  1. WD40-repeat domain binding Source: UniProtKB
  2. protein binding Source: UniProtKB
  3. ubiquitin-specific protease activity Source: UniProtKB
Complete GO annotation...

GO - Biological processi

  1. base-excision repair Source: UniProtKB
  2. cellular response to DNA damage stimulus Source: UniProtKB
  3. cellular response to UV Source: UniProtKB
  4. monoubiquitinated protein deubiquitination Source: UniProtKB
  5. negative regulation of G2/M transition of mitotic cell cycle Source: UniProtKB
  6. negative regulation of apoptotic process Source: UniProtKB
  7. negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: UniProtKB
  8. negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage Source: Ensembl
  9. negative regulation of transcription, DNA-templated Source: UniProtKB
  10. positive regulation of cell growth Source: UniProtKB
  11. response to drug Source: UniProtKB
  12. ubiquitin-dependent protein catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Keywords - Biological processi

DNA damage, DNA repair, Ubl conjugation pathway

Protein family/group databases

MEROPSiC19.055.

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin carboxyl-terminal hydrolase 47 (EC:3.4.19.12)
Alternative name(s):
Deubiquitinating enzyme 47
Ubiquitin thioesterase 47
Ubiquitin-specific-processing protease 47
Gene namesi
Name:USP47
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:20076. USP47.

Subcellular locationi

Cytoplasm 1 Publication

GO - Cellular componenti

  1. SCF ubiquitin ligase complex Source: UniProtKB
  2. cytoplasm Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134880952.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 13751375Ubiquitin carboxyl-terminal hydrolase 47
PRO_0000080676Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei122 – 1221N6-acetyllysine1 Publication
Modified residuei832 – 8321Phosphoserine3 Publications
Modified residuei910 – 9101Phosphoserine3 Publications
Modified residuei1015 – 10151Phosphothreonine By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ96K76.
PaxDbiQ96K76.
PRIDEiQ96K76.

PTM databases

PhosphoSiteiQ96K76.

Expressioni

Tissue specificityi

Expressed in skeletal muscle, heart and testis.1 Publication

Gene expression databases

ArrayExpressiQ96K76.
BgeeiQ96K76.
CleanExiHS_USP47.
GenevestigatoriQ96K76.

Organism-specific databases

HPAiHPA029286.
HPA029289.

Interactioni

Subunit structurei

Interacts with BTRC and FBXW11. Interacts with POLB.2 Publications

Protein-protein interaction databases

BioGridi120360. 14 interactions.
DIPiDIP-53629N.
IntActiQ96K76. 3 interactions.
STRINGi9606.ENSP00000339957.

Structurei

3D structure databases

ProteinModelPortaliQ96K76.
SMRiQ96K76. Positions 182-596.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini188 – 564377USP
Add
BLAST

Sequence similaritiesi

Belongs to the peptidase C19 family.
Contains 1 USP domain.

Phylogenomic databases

eggNOGiCOG5077.
HOVERGENiHBG058854.
InParanoidiQ96K76.
KOiK11857.
OMAiLCEISGI.
OrthoDBiEOG7M3HZD.
PhylomeDBiQ96K76.
TreeFamiTF314142.

Family and domain databases

InterProiIPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR029071. Ubiquitin-rel_dom.
IPR028889. UCH/PAN2.
[Graphical view]
PfamiPF00443. UCH. 1 hit.
[Graphical view]
SUPFAMiSSF54236. SSF54236. 1 hit.
PROSITEiPS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q96K76-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MVPGEENQLV PKEDVFWRCR QNIFDEMKKK FLQIENAAEE PRVLCIIQDT     50
TNSKTVNERI TLNLPASTPV RKLFEDVANK VGYINGTFDL VWGNGINTAD 100
MAPLDHTSDK SLLDANFEPG KKNFLHLTDK DGEQPQILLE DSSAGEDSVH 150
DRFIGPLPRE GSGGSTSDYV SQSYSYSSIL NKSETGYVGL VNQAMTCYLN 200
SLLQTLFMTP EFRNALYKWE FEESEEDPVT SIPYQLQRLF VLLQTSKKRA 250
IETTDVTRSF GWDSSEAWQQ HDVQELCRVM FDALEQKWKQ TEQADLINEL 300
YQGKLKDYVR CLECGYEGWR IDTYLDIPLV IRPYGSSQAF ASVEEALHAF 350
IQPEILDGPN QYFCERCKKK CDARKGLRFL HFPYLLTLQL KRFDFDYTTM 400
HRIKLNDRMT FPEELDMSTF IDVEDEKSPQ TESCTDSGAE NEGSCHSDQM 450
SNDFSNDDGV DEGICLETNS GTEKISKSGL EKNSLIYELF SVMVHSGSAA 500
GGHYYACIKS FSDEQWYSFN DQHVSRITQE DIKKTHGGSS GSRGYYSSAF 550
ASSTNAYMLI YRLKDPARNA KFLEVDEYPE HIKNLVQKER ELEEQEKRQR 600
EIERNTCKIK LFCLHPTKQV MMENKLEVHK DKTLKEAVEM AYKMMDLEEV 650
IPLDCCRLVK YDEFHDYLER SYEGEEDTPM GLLLGGVKST YMFDLLLETR 700
KPDQVFQSYK PGEVMVKVHV VDLKAESVAA PITVRAYLNQ TVTEFKQLIS 750
KAIHLPAETM RIVLERCYND LRLLSVSSKT LKAEGFFRSN KVFVESSETL 800
DYQMAFADSH LWKLLDRHAN TIRLFVLLPE QSPVSYSKRT AYQKAGGDSG 850
NVDDDCERVK GPVGSLKSVE AILEESTEKL KSLSLQQQQD GDNGDSSKST 900
ETSDFENIES PLNERDSSAS VDNRELEQHI QTSDPENFQS EERSDSDVNN 950
DRSTSSVDSD ILSSSHSSDT LCNADNAQIP LANGLDSHSI TSSRRTKANE 1000
GKKETWDTAE EDSGTDSEYD ESGKSRGEMQ YMYFKAEPYA ADEGSGEGHK 1050
WLMVHVDKRI TLAAFKQHLE PFVGVLSSHF KVFRVYASNQ EFESVRLNET 1100
LSSFSDDNKI TIRLGRALKK GEYRVKVYQL LVNEQEPCKF LLDAVFAKGM 1150
TVRQSKEELI PQLREQCGLE LSIDRFRLRK KTWKNPGTVF LDYHIYEEDI 1200
NISSNWEVFL EVLDGVEKMK SMSQLAVLSR RWKPSEMKLD PFQEVVLESS 1250
SVDELREKLS EISGIPLDDI EFAKGRGTFP CDISVLDIHQ DLDWNPKVST 1300
LNVWPLYICD DGAVIFYRDK TEELMELTDE QRNELMKKES SRLQKTGHRV 1350
TYSPRKEKAL KIYLDGAPNK DLTQD 1375
Length:1,375
Mass (Da):157,311
Last modified:November 30, 2010 - v3
Checksum:i1EDEAA9B5AFC97FE
GO
Isoform 2 (identifier: Q96K76-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     14-101: Missing.

Show »
Length:1,287
Mass (Da):147,223
Checksum:i2A332C63E843B074
GO
Isoform 3 (identifier: Q96K76-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1218: Missing.

Note: No experimental confirmation available.

Show »
Length:157
Mass (Da):18,150
Checksum:i95A4D6BB8090CD30
GO
Isoform 4 (identifier: Q96K76-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     14-33: Missing.

Note: No experimental confirmation available.

Show »
Length:1,355
Mass (Da):154,697
Checksum:i1AE6E4E9054F921A
GO

Sequence cautioni

The sequence BC071559 differs from that shown. Reason: Frameshift at position 707.
The sequence BAA91348.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti163 – 1631G → V.3 Publications
Corresponds to variant rs11022079 [ dbSNP | Ensembl ].
VAR_022787

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 12181218Missing in isoform 3.
VSP_014414Add
BLAST
Alternative sequencei14 – 10188Missing in isoform 2.
VSP_014415Add
BLAST
Alternative sequencei14 – 3320Missing in isoform 4.
VSP_055650Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti340 – 3401F → L in BAG54467. 1 Publication
Sequence conflicti494 – 4941V → A in BAB55063. 1 Publication
Sequence conflicti494 – 4941V → A in BAG54467. 1 Publication
Sequence conflicti494 – 4941V → A in BC071559. 1 Publication
Sequence conflicti520 – 5201N → D in BAB55063. 1 Publication
Sequence conflicti576 – 5761D → G in BAB55063. 1 Publication
Sequence conflicti604 – 6041R → G in BAB84902. 1 Publication
Sequence conflicti911 – 9111P → S in BAG54467. 1 Publication
Sequence conflicti1157 – 11571E → G in BAA91348. 1 Publication
Sequence conflicti1313 – 13131A → G in BAA91348. 1 Publication
Sequence conflicti1368 – 13681P → Q in BC071559. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK000734 mRNA. Translation: BAA91348.1. Different initiation.
AK027362 mRNA. Translation: BAB55063.1.
AK092290 mRNA. No translation available.
AK127264 mRNA. Translation: BAG54467.1.
AC104383 Genomic DNA. No translation available.
AC124276 Genomic DNA. No translation available.
BC000226 mRNA. Translation: AAH00226.2.
BC047044 mRNA. Translation: AAH47044.2.
BC071559 mRNA. No translation available.
AK074076 mRNA. Translation: BAB84902.1.
AL832991 mRNA. Translation: CAH56337.1.
CCDSiCCDS41619.1. [Q96K76-2]
RefSeqiNP_001269588.1. NM_001282659.1.
NP_060414.3. NM_017944.3. [Q96K76-2]
XP_005253054.1. XM_005252997.1. [Q96K76-1]
UniGeneiHs.577256.

Genome annotation databases

EnsembliENST00000339865; ENSP00000339957; ENSG00000170242. [Q96K76-2]
ENST00000399455; ENSP00000382382; ENSG00000170242. [Q96K76-1]
ENST00000527733; ENSP00000433146; ENSG00000170242.
ENST00000539466; ENSP00000440405; ENSG00000170242. [Q96K76-3]
GeneIDi55031.
KEGGihsa:55031.
UCSCiuc001mjq.1. human. [Q96K76-1]
uc001mjr.3. human. [Q96K76-2]
uc009ygi.3. human. [Q96K76-3]

Polymorphism databases

DMDMi313104266.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK000734 mRNA. Translation: BAA91348.1 . Different initiation.
AK027362 mRNA. Translation: BAB55063.1 .
AK092290 mRNA. No translation available.
AK127264 mRNA. Translation: BAG54467.1 .
AC104383 Genomic DNA. No translation available.
AC124276 Genomic DNA. No translation available.
BC000226 mRNA. Translation: AAH00226.2 .
BC047044 mRNA. Translation: AAH47044.2 .
BC071559 mRNA. No translation available.
AK074076 mRNA. Translation: BAB84902.1 .
AL832991 mRNA. Translation: CAH56337.1 .
CCDSi CCDS41619.1. [Q96K76-2 ]
RefSeqi NP_001269588.1. NM_001282659.1.
NP_060414.3. NM_017944.3. [Q96K76-2 ]
XP_005253054.1. XM_005252997.1. [Q96K76-1 ]
UniGenei Hs.577256.

3D structure databases

ProteinModelPortali Q96K76.
SMRi Q96K76. Positions 182-596.
ModBasei Search...

Protein-protein interaction databases

BioGridi 120360. 14 interactions.
DIPi DIP-53629N.
IntActi Q96K76. 3 interactions.
STRINGi 9606.ENSP00000339957.

Chemistry

ChEMBLi CHEMBL2157851.

Protein family/group databases

MEROPSi C19.055.

PTM databases

PhosphoSitei Q96K76.

Polymorphism databases

DMDMi 313104266.

Proteomic databases

MaxQBi Q96K76.
PaxDbi Q96K76.
PRIDEi Q96K76.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000339865 ; ENSP00000339957 ; ENSG00000170242 . [Q96K76-2 ]
ENST00000399455 ; ENSP00000382382 ; ENSG00000170242 . [Q96K76-1 ]
ENST00000527733 ; ENSP00000433146 ; ENSG00000170242 .
ENST00000539466 ; ENSP00000440405 ; ENSG00000170242 . [Q96K76-3 ]
GeneIDi 55031.
KEGGi hsa:55031.
UCSCi uc001mjq.1. human. [Q96K76-1 ]
uc001mjr.3. human. [Q96K76-2 ]
uc009ygi.3. human. [Q96K76-3 ]

Organism-specific databases

CTDi 55031.
GeneCardsi GC11P011819.
HGNCi HGNC:20076. USP47.
HPAi HPA029286.
HPA029289.
MIMi 614460. gene.
neXtProti NX_Q96K76.
PharmGKBi PA134880952.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5077.
HOVERGENi HBG058854.
InParanoidi Q96K76.
KOi K11857.
OMAi LCEISGI.
OrthoDBi EOG7M3HZD.
PhylomeDBi Q96K76.
TreeFami TF314142.

Miscellaneous databases

ChiTaRSi USP47. human.
GeneWikii USP47.
GenomeRNAii 55031.
NextBioi 58447.
PROi Q96K76.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q96K76.
Bgeei Q96K76.
CleanExi HS_USP47.
Genevestigatori Q96K76.

Family and domain databases

InterProi IPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR029071. Ubiquitin-rel_dom.
IPR028889. UCH/PAN2.
[Graphical view ]
Pfami PF00443. UCH. 1 hit.
[Graphical view ]
SUPFAMi SSF54236. SSF54236. 1 hit.
PROSITEi PS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT VAL-163.
    Tissue: Embryo, Hepatoma and Spleen.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3 AND 4), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 940-1375 (ISOFORMS 1/2), VARIANT VAL-163.
    Tissue: Eye and Testis.
  4. "The nucleotide sequence of a long cDNA clone isolated from human spleen."
    Jikuya H., Takano J., Nomura N., Kikuno R., Nagase T., Ohara O.
    Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 604-1375 (ISOFORMS 1/2).
    Tissue: Spleen.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 630-1375 (ISOFORMS 1/2).
    Tissue: Stomach.
  6. "Cloning and enzymatic analysis of 22 novel human ubiquitin-specific proteases."
    Quesada V., Diaz-Perales A., Gutierrez-Fernandez A., Garabaya C., Cal S., Lopez-Otin C.
    Biochem. Biophys. Res. Commun. 314:54-62(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  7. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."
    Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.
    Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-832, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  8. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-832 AND SER-910, VARIANT [LARGE SCALE ANALYSIS] VAL-163, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  9. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-910, VARIANT [LARGE SCALE ANALYSIS] VAL-163, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  10. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
    Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
    Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-122, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  11. "The ubiquitin-specific protease USP47 is a novel beta-TRCP interactor regulating cell survival."
    Peschiaroli A., Skaar J.R., Pagano M., Melino G.
    Oncogene 29:1384-1393(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH BTRC AND FBXW11.
  12. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-832 AND SER-910, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  13. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  14. "USP47 is a deubiquitylating enzyme that regulates base excision repair by controlling steady-state levels of DNA Polymerase beta."
    Parsons J.L., Dianova I.I., Khoronenkova S.V., Edelmann M.J., Kessler B.M., Dianov G.L.
    Mol. Cell 41:609-615(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, CATALYTIC ACTIVITY, SUBCELLULAR LOCATION, INTERACTION WITH POLB.

Entry informationi

Entry nameiUBP47_HUMAN
AccessioniPrimary (citable) accession number: Q96K76
Secondary accession number(s): B3KXF5
, E9PM46, Q658U0, Q86Y73, Q8TEP6, Q9BWI0, Q9NWN1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: November 30, 2010
Last modified: September 3, 2014
This is version 112 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Peptidase families
    Classification of peptidase families and list of entries
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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