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Protein

Ubiquitin carboxyl-terminal hydrolase 47

Gene

USP47

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Ubiquitin-specific protease that specifically deubiquitinates monoubiquitinated DNA polymerase beta (POLB), stabilizing POLB thereby playing a role in base-excision repair (BER). Acts as a regulator of cell growth and genome integrity. May also indirectly regulates CDC25A expression at a transcriptional level.2 Publications

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei197 – 1971NucleophilePROSITE-ProRule annotation
Active sitei503 – 5031Proton acceptorPROSITE-ProRule annotation

GO - Molecular functioni

  • cysteine-type endopeptidase activity Source: GO_Central
  • ubiquitin-specific protease activity Source: UniProtKB
  • WD40-repeat domain binding Source: UniProtKB

GO - Biological processi

  • base-excision repair Source: UniProtKB
  • cellular response to DNA damage stimulus Source: UniProtKB
  • cellular response to UV Source: UniProtKB
  • monoubiquitinated protein deubiquitination Source: UniProtKB
  • negative regulation of apoptotic process Source: UniProtKB
  • negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: UniProtKB
  • negative regulation of G2/M transition of mitotic cell cycle Source: UniProtKB
  • negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage Source: Ensembl
  • negative regulation of transcription, DNA-templated Source: UniProtKB
  • positive regulation of cell growth Source: UniProtKB
  • proteasome-mediated ubiquitin-dependent protein catabolic process Source: GO_Central
  • regulation of proteasomal protein catabolic process Source: GO_Central
  • response to drug Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Keywords - Biological processi

DNA damage, DNA repair, Ubl conjugation pathway

Protein family/group databases

MEROPSiC19.055.

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin carboxyl-terminal hydrolase 47 (EC:3.4.19.12)
Alternative name(s):
Deubiquitinating enzyme 47
Ubiquitin thioesterase 47
Ubiquitin-specific-processing protease 47
Gene namesi
Name:USP47
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:20076. USP47.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • nucleus Source: GO_Central
  • SCF ubiquitin ligase complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134880952.

Polymorphism and mutation databases

BioMutaiUSP47.
DMDMi313104266.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 13751375Ubiquitin carboxyl-terminal hydrolase 47PRO_0000080676Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei122 – 1221N6-acetyllysine1 Publication
Modified residuei832 – 8321Phosphoserine3 Publications
Modified residuei910 – 9101Phosphoserine3 Publications
Modified residuei1013 – 10131Phosphoserine1 Publication
Modified residuei1015 – 10151Phosphothreonine1 Publication
Modified residuei1017 – 10171Phosphoserine1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ96K76.
PaxDbiQ96K76.
PRIDEiQ96K76.

PTM databases

PhosphoSiteiQ96K76.

Expressioni

Tissue specificityi

Expressed in skeletal muscle, heart and testis.1 Publication

Gene expression databases

BgeeiQ96K76.
CleanExiHS_USP47.
GenevisibleiQ96K76. HS.

Organism-specific databases

HPAiHPA029286.
HPA029289.

Interactioni

Subunit structurei

Interacts with BTRC and FBXW11. Interacts with POLB.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
AP4M1O001893EBI-2514143,EBI-3914106

Protein-protein interaction databases

BioGridi120360. 23 interactions.
DIPiDIP-53629N.
IntActiQ96K76. 4 interactions.
STRINGi9606.ENSP00000339957.

Structurei

3D structure databases

ProteinModelPortaliQ96K76.
SMRiQ96K76. Positions 182-596.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini188 – 564377USPAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase C19 family.Curated
Contains 1 USP domain.Curated

Phylogenomic databases

eggNOGiCOG5077.
GeneTreeiENSGT00760000119158.
HOVERGENiHBG058854.
InParanoidiQ96K76.
KOiK11857.
OMAiSDDQWYS.
OrthoDBiEOG7M3HZD.
PhylomeDBiQ96K76.
TreeFamiTF314142.

Family and domain databases

InterProiIPR001394. Peptidase_C19_UCH.
IPR029071. Ubiquitin-rel_dom.
IPR018200. USP_CS.
IPR028889. USP_dom.
[Graphical view]
PfamiPF00443. UCH. 1 hit.
[Graphical view]
SUPFAMiSSF54236. SSF54236. 1 hit.
PROSITEiPS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96K76-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVPGEENQLV PKEDVFWRCR QNIFDEMKKK FLQIENAAEE PRVLCIIQDT
60 70 80 90 100
TNSKTVNERI TLNLPASTPV RKLFEDVANK VGYINGTFDL VWGNGINTAD
110 120 130 140 150
MAPLDHTSDK SLLDANFEPG KKNFLHLTDK DGEQPQILLE DSSAGEDSVH
160 170 180 190 200
DRFIGPLPRE GSGGSTSDYV SQSYSYSSIL NKSETGYVGL VNQAMTCYLN
210 220 230 240 250
SLLQTLFMTP EFRNALYKWE FEESEEDPVT SIPYQLQRLF VLLQTSKKRA
260 270 280 290 300
IETTDVTRSF GWDSSEAWQQ HDVQELCRVM FDALEQKWKQ TEQADLINEL
310 320 330 340 350
YQGKLKDYVR CLECGYEGWR IDTYLDIPLV IRPYGSSQAF ASVEEALHAF
360 370 380 390 400
IQPEILDGPN QYFCERCKKK CDARKGLRFL HFPYLLTLQL KRFDFDYTTM
410 420 430 440 450
HRIKLNDRMT FPEELDMSTF IDVEDEKSPQ TESCTDSGAE NEGSCHSDQM
460 470 480 490 500
SNDFSNDDGV DEGICLETNS GTEKISKSGL EKNSLIYELF SVMVHSGSAA
510 520 530 540 550
GGHYYACIKS FSDEQWYSFN DQHVSRITQE DIKKTHGGSS GSRGYYSSAF
560 570 580 590 600
ASSTNAYMLI YRLKDPARNA KFLEVDEYPE HIKNLVQKER ELEEQEKRQR
610 620 630 640 650
EIERNTCKIK LFCLHPTKQV MMENKLEVHK DKTLKEAVEM AYKMMDLEEV
660 670 680 690 700
IPLDCCRLVK YDEFHDYLER SYEGEEDTPM GLLLGGVKST YMFDLLLETR
710 720 730 740 750
KPDQVFQSYK PGEVMVKVHV VDLKAESVAA PITVRAYLNQ TVTEFKQLIS
760 770 780 790 800
KAIHLPAETM RIVLERCYND LRLLSVSSKT LKAEGFFRSN KVFVESSETL
810 820 830 840 850
DYQMAFADSH LWKLLDRHAN TIRLFVLLPE QSPVSYSKRT AYQKAGGDSG
860 870 880 890 900
NVDDDCERVK GPVGSLKSVE AILEESTEKL KSLSLQQQQD GDNGDSSKST
910 920 930 940 950
ETSDFENIES PLNERDSSAS VDNRELEQHI QTSDPENFQS EERSDSDVNN
960 970 980 990 1000
DRSTSSVDSD ILSSSHSSDT LCNADNAQIP LANGLDSHSI TSSRRTKANE
1010 1020 1030 1040 1050
GKKETWDTAE EDSGTDSEYD ESGKSRGEMQ YMYFKAEPYA ADEGSGEGHK
1060 1070 1080 1090 1100
WLMVHVDKRI TLAAFKQHLE PFVGVLSSHF KVFRVYASNQ EFESVRLNET
1110 1120 1130 1140 1150
LSSFSDDNKI TIRLGRALKK GEYRVKVYQL LVNEQEPCKF LLDAVFAKGM
1160 1170 1180 1190 1200
TVRQSKEELI PQLREQCGLE LSIDRFRLRK KTWKNPGTVF LDYHIYEEDI
1210 1220 1230 1240 1250
NISSNWEVFL EVLDGVEKMK SMSQLAVLSR RWKPSEMKLD PFQEVVLESS
1260 1270 1280 1290 1300
SVDELREKLS EISGIPLDDI EFAKGRGTFP CDISVLDIHQ DLDWNPKVST
1310 1320 1330 1340 1350
LNVWPLYICD DGAVIFYRDK TEELMELTDE QRNELMKKES SRLQKTGHRV
1360 1370
TYSPRKEKAL KIYLDGAPNK DLTQD
Length:1,375
Mass (Da):157,311
Last modified:November 30, 2010 - v3
Checksum:i1EDEAA9B5AFC97FE
GO
Isoform 2 (identifier: Q96K76-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     14-101: Missing.

Show »
Length:1,287
Mass (Da):147,223
Checksum:i2A332C63E843B074
GO
Isoform 3 (identifier: Q96K76-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1218: Missing.

Note: No experimental confirmation available.
Show »
Length:157
Mass (Da):18,150
Checksum:i95A4D6BB8090CD30
GO
Isoform 4 (identifier: Q96K76-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     14-33: Missing.

Note: No experimental confirmation available.
Show »
Length:1,355
Mass (Da):154,697
Checksum:i1AE6E4E9054F921A
GO

Sequence cautioni

The sequence BAA91348.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BC071559 differs from that shown. Reason: Frameshift at position 707. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti340 – 3401F → L in BAG54467 (PubMed:14702039).Curated
Sequence conflicti494 – 4941V → A in BAB55063 (PubMed:14702039).Curated
Sequence conflicti494 – 4941V → A in BAG54467 (PubMed:14702039).Curated
Sequence conflicti494 – 4941V → A in BC071559 (PubMed:15489334).Curated
Sequence conflicti520 – 5201N → D in BAB55063 (PubMed:14702039).Curated
Sequence conflicti576 – 5761D → G in BAB55063 (PubMed:14702039).Curated
Sequence conflicti604 – 6041R → G in BAB84902 (Ref. 4) Curated
Sequence conflicti911 – 9111P → S in BAG54467 (PubMed:14702039).Curated
Sequence conflicti1157 – 11571E → G in BAA91348 (PubMed:14702039).Curated
Sequence conflicti1313 – 13131A → G in BAA91348 (PubMed:14702039).Curated
Sequence conflicti1368 – 13681P → Q in BC071559 (PubMed:15489334).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti163 – 1631G → V.4 Publications
Corresponds to variant rs11022079 [ dbSNP | Ensembl ].
VAR_022787

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 12181218Missing in isoform 3. 1 PublicationVSP_014414Add
BLAST
Alternative sequencei14 – 10188Missing in isoform 2. 1 PublicationVSP_014415Add
BLAST
Alternative sequencei14 – 3320Missing in isoform 4. 1 PublicationVSP_055650Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK000734 mRNA. Translation: BAA91348.1. Different initiation.
AK027362 mRNA. Translation: BAB55063.1.
AK092290 mRNA. No translation available.
AK127264 mRNA. Translation: BAG54467.1.
AC104383 Genomic DNA. No translation available.
AC124276 Genomic DNA. No translation available.
BC000226 mRNA. Translation: AAH00226.2.
BC047044 mRNA. Translation: AAH47044.2.
BC071559 mRNA. No translation available.
AK074076 mRNA. Translation: BAB84902.1.
AL832991 mRNA. Translation: CAH56337.1.
CCDSiCCDS41619.1. [Q96K76-2]
CCDS60725.1. [Q96K76-4]
RefSeqiNP_001269588.1. NM_001282659.1. [Q96K76-4]
NP_060414.3. NM_017944.3. [Q96K76-2]
XP_005253054.1. XM_005252997.1. [Q96K76-1]
UniGeneiHs.577256.

Genome annotation databases

EnsembliENST00000339865; ENSP00000339957; ENSG00000170242. [Q96K76-2]
ENST00000399455; ENSP00000382382; ENSG00000170242.
ENST00000527733; ENSP00000433146; ENSG00000170242. [Q96K76-4]
GeneIDi55031.
KEGGihsa:55031.
UCSCiuc001mjq.1. human. [Q96K76-1]
uc001mjr.3. human. [Q96K76-2]
uc009ygi.3. human. [Q96K76-3]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK000734 mRNA. Translation: BAA91348.1. Different initiation.
AK027362 mRNA. Translation: BAB55063.1.
AK092290 mRNA. No translation available.
AK127264 mRNA. Translation: BAG54467.1.
AC104383 Genomic DNA. No translation available.
AC124276 Genomic DNA. No translation available.
BC000226 mRNA. Translation: AAH00226.2.
BC047044 mRNA. Translation: AAH47044.2.
BC071559 mRNA. No translation available.
AK074076 mRNA. Translation: BAB84902.1.
AL832991 mRNA. Translation: CAH56337.1.
CCDSiCCDS41619.1. [Q96K76-2]
CCDS60725.1. [Q96K76-4]
RefSeqiNP_001269588.1. NM_001282659.1. [Q96K76-4]
NP_060414.3. NM_017944.3. [Q96K76-2]
XP_005253054.1. XM_005252997.1. [Q96K76-1]
UniGeneiHs.577256.

3D structure databases

ProteinModelPortaliQ96K76.
SMRiQ96K76. Positions 182-596.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120360. 23 interactions.
DIPiDIP-53629N.
IntActiQ96K76. 4 interactions.
STRINGi9606.ENSP00000339957.

Chemistry

BindingDBiQ96K76.
ChEMBLiCHEMBL2157851.

Protein family/group databases

MEROPSiC19.055.

PTM databases

PhosphoSiteiQ96K76.

Polymorphism and mutation databases

BioMutaiUSP47.
DMDMi313104266.

Proteomic databases

MaxQBiQ96K76.
PaxDbiQ96K76.
PRIDEiQ96K76.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000339865; ENSP00000339957; ENSG00000170242. [Q96K76-2]
ENST00000399455; ENSP00000382382; ENSG00000170242.
ENST00000527733; ENSP00000433146; ENSG00000170242. [Q96K76-4]
GeneIDi55031.
KEGGihsa:55031.
UCSCiuc001mjq.1. human. [Q96K76-1]
uc001mjr.3. human. [Q96K76-2]
uc009ygi.3. human. [Q96K76-3]

Organism-specific databases

CTDi55031.
GeneCardsiGC11P011819.
HGNCiHGNC:20076. USP47.
HPAiHPA029286.
HPA029289.
MIMi614460. gene.
neXtProtiNX_Q96K76.
PharmGKBiPA134880952.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG5077.
GeneTreeiENSGT00760000119158.
HOVERGENiHBG058854.
InParanoidiQ96K76.
KOiK11857.
OMAiSDDQWYS.
OrthoDBiEOG7M3HZD.
PhylomeDBiQ96K76.
TreeFamiTF314142.

Miscellaneous databases

ChiTaRSiUSP47. human.
GeneWikiiUSP47.
GenomeRNAii55031.
NextBioi35503418.
PROiQ96K76.
SOURCEiSearch...

Gene expression databases

BgeeiQ96K76.
CleanExiHS_USP47.
GenevisibleiQ96K76. HS.

Family and domain databases

InterProiIPR001394. Peptidase_C19_UCH.
IPR029071. Ubiquitin-rel_dom.
IPR018200. USP_CS.
IPR028889. USP_dom.
[Graphical view]
PfamiPF00443. UCH. 1 hit.
[Graphical view]
SUPFAMiSSF54236. SSF54236. 1 hit.
PROSITEiPS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT VAL-163.
    Tissue: Embryo, Hepatoma and Spleen.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3 AND 4), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 940-1375 (ISOFORMS 1/2), VARIANT VAL-163.
    Tissue: Eye and Testis.
  4. "The nucleotide sequence of a long cDNA clone isolated from human spleen."
    Jikuya H., Takano J., Nomura N., Kikuno R., Nagase T., Ohara O.
    Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 604-1375 (ISOFORMS 1/2).
    Tissue: Spleen.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 630-1375 (ISOFORMS 1/2).
    Tissue: Stomach.
  6. "Cloning and enzymatic analysis of 22 novel human ubiquitin-specific proteases."
    Quesada V., Diaz-Perales A., Gutierrez-Fernandez A., Garabaya C., Cal S., Lopez-Otin C.
    Biochem. Biophys. Res. Commun. 314:54-62(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  7. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."
    Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.
    Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-832, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  8. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-832 AND SER-910, VARIANT [LARGE SCALE ANALYSIS] VAL-163, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  9. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-910, VARIANT [LARGE SCALE ANALYSIS] VAL-163, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  10. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
    Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
    Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-122, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  11. "The ubiquitin-specific protease USP47 is a novel beta-TRCP interactor regulating cell survival."
    Peschiaroli A., Skaar J.R., Pagano M., Melino G.
    Oncogene 29:1384-1393(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH BTRC AND FBXW11.
  12. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-832 AND SER-910, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  13. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  14. "USP47 is a deubiquitylating enzyme that regulates base excision repair by controlling steady-state levels of DNA Polymerase beta."
    Parsons J.L., Dianova I.I., Khoronenkova S.V., Edelmann M.J., Kessler B.M., Dianov G.L.
    Mol. Cell 41:609-615(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, CATALYTIC ACTIVITY, SUBCELLULAR LOCATION, INTERACTION WITH POLB.
  15. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1013; THR-1015 AND SER-1017, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiUBP47_HUMAN
AccessioniPrimary (citable) accession number: Q96K76
Secondary accession number(s): B3KXF5
, E9PM46, Q658U0, Q86Y73, Q8TEP6, Q9BWI0, Q9NWN1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: November 30, 2010
Last modified: July 22, 2015
This is version 121 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Was initially thought to catalytically inactive (PubMed:14715245). However, it was later shown that it is active (PubMed:21362556).2 Publications

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Peptidase families
    Classification of peptidase families and list of entries
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.