Q96K76 (UBP47_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ubiquitin carboxyl-terminal hydrolase 47
EC=3.4.19.12

Alternative name(s):
Deubiquitinating enzyme 47
Ubiquitin thioesterase 47
Ubiquitin-specific-processing protease 47

Gene names

Name:

USP47

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1375 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Ubiquitin-specific protease that specifically deubiquitinates monoubiquitinated DNA polymerase beta (POLB), stabilizing POLB thereby playing a role in base-excision repair (BER). Acts as a regulator of cell growth and genome integrity. May also indirectly regulates CDC25A expression at a transcriptional level. Ref.12 Ref.15
Catalytic activity	Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal). Ref.15
Subunit structure	Interacts with BTRC and FBXW11. Interacts with POLB. Ref.12 Ref.15
Subcellular location	Cytoplasm Ref.15.
Tissue specificity	Expressed in skeletal muscle, heart and testis. Ref.6
Sequence similarities	Belongs to the peptidase C19 family.
Caution	Was initially thought to catalytically inactive (Ref.6). However, it was later shown that it is active (Ref.15).
Sequence caution	The sequence BAA91348.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Ontologies

Keywords
Biological process	DNA damage DNA repair Ubl conjugation pathway
Cellular component	Cytoplasm
Coding sequence diversity	Alternative splicing Polymorphism
Molecular function	Hydrolase Protease Thiol protease
PTM	Acetylation Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	base-excision repair Inferred from mutant phenotype Ref.15. Source: UniProtKB cellular response to UV Inferred from sequence or structural similarity Ref.12. Source: UniProtKB monoubiquitinated protein deubiquitination Inferred from direct assay Ref.15. Source: UniProtKB negative regulation of G2/M transition of mitotic cell cycle Inferred from mutant phenotype Ref.12. Source: UniProtKB negative regulation of apoptotic process Inferred from mutant phenotype Ref.12. Source: UniProtKB negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Inferred from mutant phenotype Ref.12. Source: UniProtKB negative regulation of transcription, DNA-dependent Inferred from mutant phenotype Ref.12. Source: UniProtKB positive regulation of cell growth Inferred from mutant phenotype Ref.12. Source: UniProtKB response to drug Inferred from mutant phenotype Ref.12. Source: UniProtKB ubiquitin-dependent protein catabolic process Inferred from electronic annotation. Source: InterPro
Cellular_component	SCF ubiquitin ligase complex Inferred from direct assay Ref.12. Source: UniProtKB cytoplasm Inferred from direct assay Ref.15. Source: UniProtKB
Molecular_function	ubiquitin thiolesterase activity Inferred from electronic annotation. Source: InterPro ubiquitin-specific protease activity Inferred from direct assay Ref.15. Source: UniProtKB
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q96K76-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q96K76-2)

The sequence of this isoform differs from the canonical sequence as follows:
     14-101: Missing.

Isoform 3 (identifier: Q96K76-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-1218: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1375	1375	Ubiquitin carboxyl-terminal hydrolase 47		PRO_0000080676
Sites
	Active site	197	1	Nucleophile By similarity
	Active site	503	1	Proton acceptor By similarity
Amino acid modifications
	Modified residue	122	1	N6-acetyllysine Ref.11
	Modified residue	832	1	Phosphoserine Ref.7 Ref.9 Ref.13
	Modified residue	910	1	Phosphoserine Ref.9 Ref.10 Ref.13
	Modified residue	1015	1	Phosphothreonine By similarity
Natural variations
	Alternative sequence	1 – 1218	1218	Missing in isoform 3.		VSP_014414
	Alternative sequence	14 – 101	88	Missing in isoform 2.		VSP_014415
	Natural variant	163	1	G → V. Ref.1 Ref.9 Ref.10 Corresponds to variant rs11022079 [ dbSNP | Ensembl ].		VAR_022787
Experimental info
	Sequence conflict	340	1	F → L in BAG54467. Ref.1
	Sequence conflict	494	1	V → A in BAB55063. Ref.1
	Sequence conflict	494	1	V → A in BAG54467. Ref.1
	Sequence conflict	520	1	N → D in BAB55063. Ref.1
	Sequence conflict	576	1	D → G in BAB55063. Ref.1
	Sequence conflict	604	1	R → G in BAB84902. Ref.4
	Sequence conflict	911	1	P → S in BAG54467. Ref.1
	Sequence conflict	1157	1	E → G in BAA91348. Ref.1
	Sequence conflict	1313	1	A → G in BAA91348. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified November 30, 2010. Version 3. Checksum: 1EDEAA9B5AFC97FE	FASTA	1,375	157,311
	10 20 30 40 50 60 MVPGEENQLV PKEDVFWRCR QNIFDEMKKK FLQIENAAEE PRVLCIIQDT TNSKTVNERI 70 80 90 100 110 120 TLNLPASTPV RKLFEDVANK VGYINGTFDL VWGNGINTAD MAPLDHTSDK SLLDANFEPG 130 140 150 160 170 180 KKNFLHLTDK DGEQPQILLE DSSAGEDSVH DRFIGPLPRE GSGGSTSDYV SQSYSYSSIL 190 200 210 220 230 240 NKSETGYVGL VNQAMTCYLN SLLQTLFMTP EFRNALYKWE FEESEEDPVT SIPYQLQRLF 250 260 270 280 290 300 VLLQTSKKRA IETTDVTRSF GWDSSEAWQQ HDVQELCRVM FDALEQKWKQ TEQADLINEL 310 320 330 340 350 360 YQGKLKDYVR CLECGYEGWR IDTYLDIPLV IRPYGSSQAF ASVEEALHAF IQPEILDGPN 370 380 390 400 410 420 QYFCERCKKK CDARKGLRFL HFPYLLTLQL KRFDFDYTTM HRIKLNDRMT FPEELDMSTF 430 440 450 460 470 480 IDVEDEKSPQ TESCTDSGAE NEGSCHSDQM SNDFSNDDGV DEGICLETNS GTEKISKSGL 490 500 510 520 530 540 EKNSLIYELF SVMVHSGSAA GGHYYACIKS FSDEQWYSFN DQHVSRITQE DIKKTHGGSS 550 560 570 580 590 600 GSRGYYSSAF ASSTNAYMLI YRLKDPARNA KFLEVDEYPE HIKNLVQKER ELEEQEKRQR 610 620 630 640 650 660 EIERNTCKIK LFCLHPTKQV MMENKLEVHK DKTLKEAVEM AYKMMDLEEV IPLDCCRLVK 670 680 690 700 710 720 YDEFHDYLER SYEGEEDTPM GLLLGGVKST YMFDLLLETR KPDQVFQSYK PGEVMVKVHV 730 740 750 760 770 780 VDLKAESVAA PITVRAYLNQ TVTEFKQLIS KAIHLPAETM RIVLERCYND LRLLSVSSKT 790 800 810 820 830 840 LKAEGFFRSN KVFVESSETL DYQMAFADSH LWKLLDRHAN TIRLFVLLPE QSPVSYSKRT 850 860 870 880 890 900 AYQKAGGDSG NVDDDCERVK GPVGSLKSVE AILEESTEKL KSLSLQQQQD GDNGDSSKST 910 920 930 940 950 960 ETSDFENIES PLNERDSSAS VDNRELEQHI QTSDPENFQS EERSDSDVNN DRSTSSVDSD 970 980 990 1000 1010 1020 ILSSSHSSDT LCNADNAQIP LANGLDSHSI TSSRRTKANE GKKETWDTAE EDSGTDSEYD 1030 1040 1050 1060 1070 1080 ESGKSRGEMQ YMYFKAEPYA ADEGSGEGHK WLMVHVDKRI TLAAFKQHLE PFVGVLSSHF 1090 1100 1110 1120 1130 1140 KVFRVYASNQ EFESVRLNET LSSFSDDNKI TIRLGRALKK GEYRVKVYQL LVNEQEPCKF 1150 1160 1170 1180 1190 1200 LLDAVFAKGM TVRQSKEELI PQLREQCGLE LSIDRFRLRK KTWKNPGTVF LDYHIYEEDI 1210 1220 1230 1240 1250 1260 NISSNWEVFL EVLDGVEKMK SMSQLAVLSR RWKPSEMKLD PFQEVVLESS SVDELREKLS 1270 1280 1290 1300 1310 1320 EISGIPLDDI EFAKGRGTFP CDISVLDIHQ DLDWNPKVST LNVWPLYICD DGAVIFYRDK 1330 1340 1350 1360 1370 TEELMELTDE QRNELMKKES SRLQKTGHRV TYSPRKEKAL KIYLDGAPNK DLTQD
	Isoform 2 [UniParc]. Checksum: 2A332C63E843B074	FASTA	1,287	147,223
	10 20 30 40 50 60 MVPGEENQLV PKEAPLDHTS DKSLLDANFE PGKKNFLHLT DKDGEQPQIL LEDSSAGEDS 70 80 90 100 110 120 VHDRFIGPLP REGSGGSTSD YVSQSYSYSS ILNKSETGYV GLVNQAMTCY LNSLLQTLFM 130 140 150 160 170 180 TPEFRNALYK WEFEESEEDP VTSIPYQLQR LFVLLQTSKK RAIETTDVTR SFGWDSSEAW 190 200 210 220 230 240 QQHDVQELCR VMFDALEQKW KQTEQADLIN ELYQGKLKDY VRCLECGYEG WRIDTYLDIP 250 260 270 280 290 300 LVIRPYGSSQ AFASVEEALH AFIQPEILDG PNQYFCERCK KKCDARKGLR FLHFPYLLTL 310 320 330 340 350 360 QLKRFDFDYT TMHRIKLNDR MTFPEELDMS TFIDVEDEKS PQTESCTDSG AENEGSCHSD 370 380 390 400 410 420 QMSNDFSNDD GVDEGICLET NSGTEKISKS GLEKNSLIYE LFSVMVHSGS AAGGHYYACI 430 440 450 460 470 480 KSFSDEQWYS FNDQHVSRIT QEDIKKTHGG SSGSRGYYSS AFASSTNAYM LIYRLKDPAR 490 500 510 520 530 540 NAKFLEVDEY PEHIKNLVQK ERELEEQEKR QREIERNTCK IKLFCLHPTK QVMMENKLEV 550 560 570 580 590 600 HKDKTLKEAV EMAYKMMDLE EVIPLDCCRL VKYDEFHDYL ERSYEGEEDT PMGLLLGGVK 610 620 630 640 650 660 STYMFDLLLE TRKPDQVFQS YKPGEVMVKV HVVDLKAESV AAPITVRAYL NQTVTEFKQL 670 680 690 700 710 720 ISKAIHLPAE TMRIVLERCY NDLRLLSVSS KTLKAEGFFR SNKVFVESSE TLDYQMAFAD 730 740 750 760 770 780 SHLWKLLDRH ANTIRLFVLL PEQSPVSYSK RTAYQKAGGD SGNVDDDCER VKGPVGSLKS 790 800 810 820 830 840 VEAILEESTE KLKSLSLQQQ QDGDNGDSSK STETSDFENI ESPLNERDSS ASVDNRELEQ 850 860 870 880 890 900 HIQTSDPENF QSEERSDSDV NNDRSTSSVD SDILSSSHSS DTLCNADNAQ IPLANGLDSH 910 920 930 940 950 960 SITSSRRTKA NEGKKETWDT AEEDSGTDSE YDESGKSRGE MQYMYFKAEP YAADEGSGEG 970 980 990 1000 1010 1020 HKWLMVHVDK RITLAAFKQH LEPFVGVLSS HFKVFRVYAS NQEFESVRLN ETLSSFSDDN 1030 1040 1050 1060 1070 1080 KITIRLGRAL KKGEYRVKVY QLLVNEQEPC KFLLDAVFAK GMTVRQSKEE LIPQLREQCG 1090 1100 1110 1120 1130 1140 LELSIDRFRL RKKTWKNPGT VFLDYHIYEE DINISSNWEV FLEVLDGVEK MKSMSQLAVL 1150 1160 1170 1180 1190 1200 SRRWKPSEMK LDPFQEVVLE SSSVDELREK LSEISGIPLD DIEFAKGRGT FPCDISVLDI 1210 1220 1230 1240 1250 1260 HQDLDWNPKV STLNVWPLYI CDDGAVIFYR DKTEELMELT DEQRNELMKK ESSRLQKTGH 1270 1280 RVTYSPRKEK ALKIYLDGAP NKDLTQD
	Isoform 3 [UniParc]. Checksum: 95A4D6BB8090CD30	FASTA	157	18,150
	10 20 30 40 50 60 MKSMSQLAVL SRRWKPSEMK LDPFQEVVLE SSSVDELREK LSEISGIPLD DIEFAKGRGT 70 80 90 100 110 120 FPCDISVLDI HQDLDWNPKV STLNVWPLYI CDDGAVIFYR DKTEELMELT DEQRNELMKK 130 140 150 ESSRLQKTGH RVTYSPRKEK ALKIYLDGAP NKDLTQD

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT VAL-163. Tissue: Embryo, Hepatoma and Spleen.
[2]	"Human chromosome 11 DNA sequence and analysis including novel gene identification." Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G. , Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S., Sakaki Y. Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 940-1375 (ISOFORMS 1/2). Tissue: Eye and Testis.
[4]	"The nucleotide sequence of a long cDNA clone isolated from human spleen." Jikuya H., Takano J., Nomura N., Kikuno R., Nagase T., Ohara O. Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 604-1375 (ISOFORMS 1/2). Tissue: Spleen.
[5]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 630-1375 (ISOFORMS 1/2). Tissue: Stomach.
[6]	"Cloning and enzymatic analysis of 22 novel human ubiquitin-specific proteases." Quesada V., Diaz-Perales A., Gutierrez-Fernandez A., Garabaya C., Cal S., Lopez-Otin C. Biochem. Biophys. Res. Commun. 314:54-62(2004) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY.
[7]	"A probability-based approach for high-throughput protein phosphorylation analysis and site localization." Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P. Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-832, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[8]	"Phosphoproteome of resting human platelets." Zahedi R.P., Lewandrowski U., Wiesner J., Wortelkamp S., Moebius J., Schuetz C., Walter U., Gambaryan S., Sickmann A. J. Proteome Res. 7:526-534(2008) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Platelet.
[9]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-832 AND SER-910, VARIANT [LARGE SCALE ANALYSIS] VAL-163, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[10]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-910, VARIANT [LARGE SCALE ANALYSIS] VAL-163, MASS SPECTROMETRY. Tissue: Leukemic T-cell.
[11]	"Lysine acetylation targets protein complexes and co-regulates major cellular functions." Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M. Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract] Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-122, MASS SPECTROMETRY.
[12]	"The ubiquitin-specific protease USP47 is a novel beta-TRCP interactor regulating cell survival." Peschiaroli A., Skaar J.R., Pagano M., Melino G. Oncogene 29:1384-1393(2010) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, INTERACTION WITH BTRC AND FBXW11.
[13]	"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis." Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M. Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-832 AND SER-910, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[14]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[15]	"USP47 is a deubiquitylating enzyme that regulates base excision repair by controlling steady-state levels of DNA Polymerase beta." Parsons J.L., Dianova I.I., Khoronenkova S.V., Edelmann M.J., Kessler B.M., Dianov G.L. Mol. Cell 41:609-615(2011) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, CATALYTIC ACTIVITY, SUBCELLULAR LOCATION, INTERACTION WITH POLB.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK000734 mRNA. Translation: BAA91348.1. Different initiation. AK027362 mRNA. Translation: BAB55063.1. AK092290 mRNA. No translation available. AK127264 mRNA. Translation: BAG54467.1. AC104383 Genomic DNA. No translation available. AC124276 Genomic DNA. No translation available. BC000226 mRNA. Translation: AAH00226.2. BC047044 mRNA. Translation: AAH47044.2. AK074076 mRNA. Translation: BAB84902.1. AL832991 mRNA. Translation: CAH56337.1.
IPI	IPI00165528. IPI00607554. IPI00607731.
RefSeq	NP_060414.3. NM_017944.3.
UniGene	Hs.577256.
3D structure databases
ProteinModelPortal	Q96K76.
SMR	Q96K76. Positions 182-596.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q96K76. 2 interactions.
STRING	9606.ENSP00000339957.
Protein family/group databases
MEROPS	C19.055.
PTM databases
PhosphoSite	Q96K76.
Polymorphism databases
DMDM	68566222.
Proteomic databases
PaxDb	Q96K76.
PRIDE	Q96K76.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000339865; ENSP00000339957; ENSG00000170242. ENST00000399455; ENSP00000382382; ENSG00000170242. ENST00000539466; ENSP00000440405; ENSG00000170242.
GeneID	55031.
KEGG	hsa:55031.
UCSC	uc001mjq.1. human. uc001mjr.3. human. uc009ygi.3. human.
Organism-specific databases
CTD	55031.
GeneCards	GC11P011819.
HGNC	HGNC:20076. USP47.
HPA	HPA029286. HPA029289.
MIM	614460. gene.
neXtProt	NX_Q96K76.
PharmGKB	PA134880952.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG5077.
HOVERGEN	HBG058854.
InParanoid	Q96K76.
KO	K11857.
OMA	NKSETGY.
Gene expression databases
ArrayExpress	Q96K76.
Bgee	Q96K76.
CleanEx	HS_USP47.
Genevestigator	Q96K76.
GermOnline	ENSG00000170242. Homo sapiens.
Family and domain databases
InterPro	IPR018200. Pept_C19ubi-hydrolase_C_CS. IPR001394. Peptidase_C19. [Graphical view]
Pfam	PF00443. UCH. 1 hit. [Graphical view]
PROSITE	PS00972. UCH_2_1. 1 hit. PS00973. UCH_2_2. 1 hit. PS50235. UCH_2_3. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	USP47. human.
GenomeRNAi	55031.
NextBio	58447.
SOURCE	Search...

Entry information

Entry name

UBP47_HUMAN

Accession

Primary (citable) accession number: Q96K76
Secondary accession number(s): B3KXF5 , Q658U0, Q86Y73, Q8TEP6, Q9BWI0, Q9NWN1

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 5, 2005
Last sequence update:	November 30, 2010
Last modified:	May 1, 2013
This is version 99 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.