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Q96K76

- UBP47_HUMAN

UniProt

Q96K76 - UBP47_HUMAN

Protein

Ubiquitin carboxyl-terminal hydrolase 47

Gene

USP47

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 113 (01 Oct 2014)
      Sequence version 3 (30 Nov 2010)
      Previous versions | rss
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    Functioni

    Ubiquitin-specific protease that specifically deubiquitinates monoubiquitinated DNA polymerase beta (POLB), stabilizing POLB thereby playing a role in base-excision repair (BER). Acts as a regulator of cell growth and genome integrity. May also indirectly regulates CDC25A expression at a transcriptional level.2 Publications

    Catalytic activityi

    Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).1 Publication

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei197 – 1971NucleophilePROSITE-ProRule annotation
    Active sitei503 – 5031Proton acceptorPROSITE-ProRule annotation

    GO - Molecular functioni

    1. cysteine-type peptidase activity Source: UniProtKB-KW
    2. protein binding Source: UniProtKB
    3. ubiquitin-specific protease activity Source: UniProtKB
    4. ubiquitinyl hydrolase activity Source: InterPro
    5. WD40-repeat domain binding Source: UniProtKB

    GO - Biological processi

    1. base-excision repair Source: UniProtKB
    2. cellular response to DNA damage stimulus Source: UniProtKB
    3. cellular response to UV Source: UniProtKB
    4. monoubiquitinated protein deubiquitination Source: UniProtKB
    5. negative regulation of apoptotic process Source: UniProtKB
    6. negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: UniProtKB
    7. negative regulation of G2/M transition of mitotic cell cycle Source: UniProtKB
    8. negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage Source: Ensembl
    9. negative regulation of transcription, DNA-templated Source: UniProtKB
    10. positive regulation of cell growth Source: UniProtKB
    11. response to drug Source: UniProtKB
    12. ubiquitin-dependent protein catabolic process Source: InterPro

    Keywords - Molecular functioni

    Hydrolase, Protease, Thiol protease

    Keywords - Biological processi

    DNA damage, DNA repair, Ubl conjugation pathway

    Protein family/group databases

    MEROPSiC19.055.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ubiquitin carboxyl-terminal hydrolase 47 (EC:3.4.19.12)
    Alternative name(s):
    Deubiquitinating enzyme 47
    Ubiquitin thioesterase 47
    Ubiquitin-specific-processing protease 47
    Gene namesi
    Name:USP47
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:20076. USP47.

    Subcellular locationi

    Cytoplasm 1 Publication

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. SCF ubiquitin ligase complex Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134880952.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 13751375Ubiquitin carboxyl-terminal hydrolase 47PRO_0000080676Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei122 – 1221N6-acetyllysine1 Publication
    Modified residuei832 – 8321Phosphoserine3 Publications
    Modified residuei910 – 9101Phosphoserine3 Publications
    Modified residuei1015 – 10151PhosphothreonineBy similarity

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiQ96K76.
    PaxDbiQ96K76.
    PRIDEiQ96K76.

    PTM databases

    PhosphoSiteiQ96K76.

    Expressioni

    Tissue specificityi

    Expressed in skeletal muscle, heart and testis.1 Publication

    Gene expression databases

    ArrayExpressiQ96K76.
    BgeeiQ96K76.
    CleanExiHS_USP47.
    GenevestigatoriQ96K76.

    Organism-specific databases

    HPAiHPA029286.
    HPA029289.

    Interactioni

    Subunit structurei

    Interacts with BTRC and FBXW11. Interacts with POLB.2 Publications

    Protein-protein interaction databases

    BioGridi120360. 14 interactions.
    DIPiDIP-53629N.
    IntActiQ96K76. 3 interactions.
    STRINGi9606.ENSP00000339957.

    Structurei

    3D structure databases

    ProteinModelPortaliQ96K76.
    SMRiQ96K76. Positions 182-596.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini188 – 564377USPAdd
    BLAST

    Sequence similaritiesi

    Belongs to the peptidase C19 family.Curated
    Contains 1 USP domain.Curated

    Phylogenomic databases

    eggNOGiCOG5077.
    HOVERGENiHBG058854.
    InParanoidiQ96K76.
    KOiK11857.
    OMAiLCEISGI.
    OrthoDBiEOG7M3HZD.
    PhylomeDBiQ96K76.
    TreeFamiTF314142.

    Family and domain databases

    InterProiIPR018200. Pept_C19ubi-hydrolase_C_CS.
    IPR001394. Peptidase_C19_UCH.
    IPR029071. Ubiquitin-rel_dom.
    IPR028889. UCH/PAN2.
    [Graphical view]
    PfamiPF00443. UCH. 1 hit.
    [Graphical view]
    SUPFAMiSSF54236. SSF54236. 1 hit.
    PROSITEiPS00972. USP_1. 1 hit.
    PS00973. USP_2. 1 hit.
    PS50235. USP_3. 1 hit.
    [Graphical view]

    Sequences (4)i

    Sequence statusi: Complete.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q96K76-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MVPGEENQLV PKEDVFWRCR QNIFDEMKKK FLQIENAAEE PRVLCIIQDT     50
    TNSKTVNERI TLNLPASTPV RKLFEDVANK VGYINGTFDL VWGNGINTAD 100
    MAPLDHTSDK SLLDANFEPG KKNFLHLTDK DGEQPQILLE DSSAGEDSVH 150
    DRFIGPLPRE GSGGSTSDYV SQSYSYSSIL NKSETGYVGL VNQAMTCYLN 200
    SLLQTLFMTP EFRNALYKWE FEESEEDPVT SIPYQLQRLF VLLQTSKKRA 250
    IETTDVTRSF GWDSSEAWQQ HDVQELCRVM FDALEQKWKQ TEQADLINEL 300
    YQGKLKDYVR CLECGYEGWR IDTYLDIPLV IRPYGSSQAF ASVEEALHAF 350
    IQPEILDGPN QYFCERCKKK CDARKGLRFL HFPYLLTLQL KRFDFDYTTM 400
    HRIKLNDRMT FPEELDMSTF IDVEDEKSPQ TESCTDSGAE NEGSCHSDQM 450
    SNDFSNDDGV DEGICLETNS GTEKISKSGL EKNSLIYELF SVMVHSGSAA 500
    GGHYYACIKS FSDEQWYSFN DQHVSRITQE DIKKTHGGSS GSRGYYSSAF 550
    ASSTNAYMLI YRLKDPARNA KFLEVDEYPE HIKNLVQKER ELEEQEKRQR 600
    EIERNTCKIK LFCLHPTKQV MMENKLEVHK DKTLKEAVEM AYKMMDLEEV 650
    IPLDCCRLVK YDEFHDYLER SYEGEEDTPM GLLLGGVKST YMFDLLLETR 700
    KPDQVFQSYK PGEVMVKVHV VDLKAESVAA PITVRAYLNQ TVTEFKQLIS 750
    KAIHLPAETM RIVLERCYND LRLLSVSSKT LKAEGFFRSN KVFVESSETL 800
    DYQMAFADSH LWKLLDRHAN TIRLFVLLPE QSPVSYSKRT AYQKAGGDSG 850
    NVDDDCERVK GPVGSLKSVE AILEESTEKL KSLSLQQQQD GDNGDSSKST 900
    ETSDFENIES PLNERDSSAS VDNRELEQHI QTSDPENFQS EERSDSDVNN 950
    DRSTSSVDSD ILSSSHSSDT LCNADNAQIP LANGLDSHSI TSSRRTKANE 1000
    GKKETWDTAE EDSGTDSEYD ESGKSRGEMQ YMYFKAEPYA ADEGSGEGHK 1050
    WLMVHVDKRI TLAAFKQHLE PFVGVLSSHF KVFRVYASNQ EFESVRLNET 1100
    LSSFSDDNKI TIRLGRALKK GEYRVKVYQL LVNEQEPCKF LLDAVFAKGM 1150
    TVRQSKEELI PQLREQCGLE LSIDRFRLRK KTWKNPGTVF LDYHIYEEDI 1200
    NISSNWEVFL EVLDGVEKMK SMSQLAVLSR RWKPSEMKLD PFQEVVLESS 1250
    SVDELREKLS EISGIPLDDI EFAKGRGTFP CDISVLDIHQ DLDWNPKVST 1300
    LNVWPLYICD DGAVIFYRDK TEELMELTDE QRNELMKKES SRLQKTGHRV 1350
    TYSPRKEKAL KIYLDGAPNK DLTQD 1375
    Length:1,375
    Mass (Da):157,311
    Last modified:November 30, 2010 - v3
    Checksum:i1EDEAA9B5AFC97FE
    GO
    Isoform 2 (identifier: Q96K76-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         14-101: Missing.

    Show »
    Length:1,287
    Mass (Da):147,223
    Checksum:i2A332C63E843B074
    GO
    Isoform 3 (identifier: Q96K76-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-1218: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:157
    Mass (Da):18,150
    Checksum:i95A4D6BB8090CD30
    GO
    Isoform 4 (identifier: Q96K76-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         14-33: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:1,355
    Mass (Da):154,697
    Checksum:i1AE6E4E9054F921A
    GO

    Sequence cautioni

    The sequence BC071559 differs from that shown. Reason: Frameshift at position 707.
    The sequence BAA91348.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti340 – 3401F → L in BAG54467. (PubMed:14702039)Curated
    Sequence conflicti494 – 4941V → A in BAB55063. (PubMed:14702039)Curated
    Sequence conflicti494 – 4941V → A in BAG54467. (PubMed:14702039)Curated
    Sequence conflicti494 – 4941V → A in BC071559. (PubMed:15489334)Curated
    Sequence conflicti520 – 5201N → D in BAB55063. (PubMed:14702039)Curated
    Sequence conflicti576 – 5761D → G in BAB55063. (PubMed:14702039)Curated
    Sequence conflicti604 – 6041R → G in BAB84902. 1 PublicationCurated
    Sequence conflicti911 – 9111P → S in BAG54467. (PubMed:14702039)Curated
    Sequence conflicti1157 – 11571E → G in BAA91348. (PubMed:14702039)Curated
    Sequence conflicti1313 – 13131A → G in BAA91348. (PubMed:14702039)Curated
    Sequence conflicti1368 – 13681P → Q in BC071559. (PubMed:15489334)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti163 – 1631G → V.4 Publications
    Corresponds to variant rs11022079 [ dbSNP | Ensembl ].
    VAR_022787

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 12181218Missing in isoform 3. 1 PublicationVSP_014414Add
    BLAST
    Alternative sequencei14 – 10188Missing in isoform 2. 1 PublicationVSP_014415Add
    BLAST
    Alternative sequencei14 – 3320Missing in isoform 4. 1 PublicationVSP_055650Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK000734 mRNA. Translation: BAA91348.1. Different initiation.
    AK027362 mRNA. Translation: BAB55063.1.
    AK092290 mRNA. No translation available.
    AK127264 mRNA. Translation: BAG54467.1.
    AC104383 Genomic DNA. No translation available.
    AC124276 Genomic DNA. No translation available.
    BC000226 mRNA. Translation: AAH00226.2.
    BC047044 mRNA. Translation: AAH47044.2.
    BC071559 mRNA. No translation available.
    AK074076 mRNA. Translation: BAB84902.1.
    AL832991 mRNA. Translation: CAH56337.1.
    CCDSiCCDS41619.1. [Q96K76-2]
    RefSeqiNP_001269588.1. NM_001282659.1.
    NP_060414.3. NM_017944.3. [Q96K76-2]
    XP_005253054.1. XM_005252997.1. [Q96K76-1]
    UniGeneiHs.577256.

    Genome annotation databases

    EnsembliENST00000339865; ENSP00000339957; ENSG00000170242. [Q96K76-2]
    ENST00000399455; ENSP00000382382; ENSG00000170242. [Q96K76-1]
    ENST00000527733; ENSP00000433146; ENSG00000170242. [Q96K76-4]
    GeneIDi55031.
    KEGGihsa:55031.
    UCSCiuc001mjq.1. human. [Q96K76-1]
    uc001mjr.3. human. [Q96K76-2]
    uc009ygi.3. human. [Q96K76-3]

    Polymorphism databases

    DMDMi313104266.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK000734 mRNA. Translation: BAA91348.1 . Different initiation.
    AK027362 mRNA. Translation: BAB55063.1 .
    AK092290 mRNA. No translation available.
    AK127264 mRNA. Translation: BAG54467.1 .
    AC104383 Genomic DNA. No translation available.
    AC124276 Genomic DNA. No translation available.
    BC000226 mRNA. Translation: AAH00226.2 .
    BC047044 mRNA. Translation: AAH47044.2 .
    BC071559 mRNA. No translation available.
    AK074076 mRNA. Translation: BAB84902.1 .
    AL832991 mRNA. Translation: CAH56337.1 .
    CCDSi CCDS41619.1. [Q96K76-2 ]
    RefSeqi NP_001269588.1. NM_001282659.1.
    NP_060414.3. NM_017944.3. [Q96K76-2 ]
    XP_005253054.1. XM_005252997.1. [Q96K76-1 ]
    UniGenei Hs.577256.

    3D structure databases

    ProteinModelPortali Q96K76.
    SMRi Q96K76. Positions 182-596.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 120360. 14 interactions.
    DIPi DIP-53629N.
    IntActi Q96K76. 3 interactions.
    STRINGi 9606.ENSP00000339957.

    Chemistry

    ChEMBLi CHEMBL2157851.

    Protein family/group databases

    MEROPSi C19.055.

    PTM databases

    PhosphoSitei Q96K76.

    Polymorphism databases

    DMDMi 313104266.

    Proteomic databases

    MaxQBi Q96K76.
    PaxDbi Q96K76.
    PRIDEi Q96K76.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000339865 ; ENSP00000339957 ; ENSG00000170242 . [Q96K76-2 ]
    ENST00000399455 ; ENSP00000382382 ; ENSG00000170242 . [Q96K76-1 ]
    ENST00000527733 ; ENSP00000433146 ; ENSG00000170242 . [Q96K76-4 ]
    GeneIDi 55031.
    KEGGi hsa:55031.
    UCSCi uc001mjq.1. human. [Q96K76-1 ]
    uc001mjr.3. human. [Q96K76-2 ]
    uc009ygi.3. human. [Q96K76-3 ]

    Organism-specific databases

    CTDi 55031.
    GeneCardsi GC11P011819.
    HGNCi HGNC:20076. USP47.
    HPAi HPA029286.
    HPA029289.
    MIMi 614460. gene.
    neXtProti NX_Q96K76.
    PharmGKBi PA134880952.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5077.
    HOVERGENi HBG058854.
    InParanoidi Q96K76.
    KOi K11857.
    OMAi LCEISGI.
    OrthoDBi EOG7M3HZD.
    PhylomeDBi Q96K76.
    TreeFami TF314142.

    Miscellaneous databases

    ChiTaRSi USP47. human.
    GeneWikii USP47.
    GenomeRNAii 55031.
    NextBioi 58447.
    PROi Q96K76.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q96K76.
    Bgeei Q96K76.
    CleanExi HS_USP47.
    Genevestigatori Q96K76.

    Family and domain databases

    InterProi IPR018200. Pept_C19ubi-hydrolase_C_CS.
    IPR001394. Peptidase_C19_UCH.
    IPR029071. Ubiquitin-rel_dom.
    IPR028889. UCH/PAN2.
    [Graphical view ]
    Pfami PF00443. UCH. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54236. SSF54236. 1 hit.
    PROSITEi PS00972. USP_1. 1 hit.
    PS00973. USP_2. 1 hit.
    PS50235. USP_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT VAL-163.
      Tissue: Embryo, Hepatoma and Spleen.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3 AND 4), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 940-1375 (ISOFORMS 1/2), VARIANT VAL-163.
      Tissue: Eye and Testis.
    4. "The nucleotide sequence of a long cDNA clone isolated from human spleen."
      Jikuya H., Takano J., Nomura N., Kikuno R., Nagase T., Ohara O.
      Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 604-1375 (ISOFORMS 1/2).
      Tissue: Spleen.
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 630-1375 (ISOFORMS 1/2).
      Tissue: Stomach.
    6. "Cloning and enzymatic analysis of 22 novel human ubiquitin-specific proteases."
      Quesada V., Diaz-Perales A., Gutierrez-Fernandez A., Garabaya C., Cal S., Lopez-Otin C.
      Biochem. Biophys. Res. Commun. 314:54-62(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.
    7. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."
      Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.
      Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-832, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    8. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-832 AND SER-910, VARIANT [LARGE SCALE ANALYSIS] VAL-163, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    9. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-910, VARIANT [LARGE SCALE ANALYSIS] VAL-163, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    10. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
      Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
      Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-122, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    11. "The ubiquitin-specific protease USP47 is a novel beta-TRCP interactor regulating cell survival."
      Peschiaroli A., Skaar J.R., Pagano M., Melino G.
      Oncogene 29:1384-1393(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH BTRC AND FBXW11.
    12. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-832 AND SER-910, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    13. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    14. "USP47 is a deubiquitylating enzyme that regulates base excision repair by controlling steady-state levels of DNA Polymerase beta."
      Parsons J.L., Dianova I.I., Khoronenkova S.V., Edelmann M.J., Kessler B.M., Dianov G.L.
      Mol. Cell 41:609-615(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, CATALYTIC ACTIVITY, SUBCELLULAR LOCATION, INTERACTION WITH POLB.

    Entry informationi

    Entry nameiUBP47_HUMAN
    AccessioniPrimary (citable) accession number: Q96K76
    Secondary accession number(s): B3KXF5
    , E9PM46, Q658U0, Q86Y73, Q8TEP6, Q9BWI0, Q9NWN1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 5, 2005
    Last sequence update: November 30, 2010
    Last modified: October 1, 2014
    This is version 113 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. Peptidase families
      Classification of peptidase families and list of entries
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3