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Protein

Zinc finger protein 514

Gene

ZNF514

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri204 – 226C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri232 – 254C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri260 – 282C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri288 – 310C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri316 – 338C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri344 – 366C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri372 – 394C2H2-type 7PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:ENSG00000144026-MONOMER.
ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 514
Gene namesi
Name:ZNF514
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:25894. ZNF514.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000144026.
PharmGKBiPA134978837.

Polymorphism and mutation databases

BioMutaiZNF514.
DMDMi42560003.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000476331 – 400Zinc finger protein 514Add BLAST400

Proteomic databases

EPDiQ96K75.
PaxDbiQ96K75.
PeptideAtlasiQ96K75.
PRIDEiQ96K75.

PTM databases

iPTMnetiQ96K75.
PhosphoSitePlusiQ96K75.

Expressioni

Gene expression databases

BgeeiENSG00000144026.
CleanExiHS_ZNF514.
ExpressionAtlasiQ96K75. baseline and differential.
GenevisibleiQ96K75. HS.

Organism-specific databases

HPAiHPA028974.

Interactioni

Protein-protein interaction databases

BioGridi124319. 1 interactor.
IntActiQ96K75. 1 interactor.
STRINGi9606.ENSP00000295208.

Structurei

3D structure databases

ProteinModelPortaliQ96K75.
SMRiQ96K75.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 72KRABPROSITE-ProRule annotationAdd BLAST72

Sequence similaritiesi

Contains 7 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri204 – 226C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri232 – 254C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri260 – 282C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri288 – 310C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri316 – 338C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri344 – 366C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri372 – 394C2H2-type 7PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129852.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ96K75.
KOiK09228.
OMAiCDTEFRQ.
OrthoDBiEOG091G02KC.
PhylomeDBiQ96K75.
TreeFamiTF337055.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 7 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 5 hits.
PF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 7 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 7 hits.
PS50157. ZINC_FINGER_C2H2_2. 7 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96K75-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTFEDVAVEF SQWEWGQLNP AQKDLYREVM LENFRNLAIL GLLVSKPYVI
60 70 80 90 100
CQLEEGGEPF MVEREISTGA HSDWKRRSKS KESMPSWGIS KEELFQVVSV
110 120 130 140 150
EKHIQDVLQF SKLKAACGCD GQLEMQQIKQ ERHLKQMSTI HKSATTLSRD
160 170 180 190 200
YKWNGFGRSL GLRSVLVNQH SILMGEGSYK CDTEFRQTLG GNNSQRTHPE
210 220 230 240 250
KKSCKCNECG KSFHFQSELR RHQRCHTGEK PYECSDCGRA FGHISSLIKH
260 270 280 290 300
QRTHTGEKPY ECSECGRAFS QSSSLVLHYR FHTGEKPYKC NECGRAFGHT
310 320 330 340 350
SSLIKHQRTH TGEKPYECRE CGRTFSQSSS LIVHYRFHTG EKPYKCNKCG
360 370 380 390 400
RAFSQSSSLT QHYRFHTGEK PYKCNECGRA FAHTASLIKH QRSHAGKKTL
Length:400
Mass (Da):45,938
Last modified:December 1, 2001 - v1
Checksum:i7BD27F892ABE3FF8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK027363 mRNA. Translation: BAB55064.1.
AL832263 mRNA. Translation: CAI46170.1.
AC092835 Genomic DNA. Translation: AAX88981.1.
BC074900 mRNA. Translation: AAH74900.1.
BC074901 mRNA. Translation: AAH74901.1.
BC110524 mRNA. Translation: AAI10525.1.
BC110525 mRNA. Translation: AAI10526.1.
CCDSiCCDS2011.1.
RefSeqiNP_001304934.1. NM_001318005.1.
NP_116177.1. NM_032788.2.
XP_006712869.1. XM_006712806.2.
UniGeneiHs.355664.
Hs.655109.

Genome annotation databases

EnsembliENST00000295208; ENSP00000295208; ENSG00000144026.
ENST00000411425; ENSP00000405509; ENSG00000144026.
GeneIDi84874.
KEGGihsa:84874.
UCSCiuc002sue.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK027363 mRNA. Translation: BAB55064.1.
AL832263 mRNA. Translation: CAI46170.1.
AC092835 Genomic DNA. Translation: AAX88981.1.
BC074900 mRNA. Translation: AAH74900.1.
BC074901 mRNA. Translation: AAH74901.1.
BC110524 mRNA. Translation: AAI10525.1.
BC110525 mRNA. Translation: AAI10526.1.
CCDSiCCDS2011.1.
RefSeqiNP_001304934.1. NM_001318005.1.
NP_116177.1. NM_032788.2.
XP_006712869.1. XM_006712806.2.
UniGeneiHs.355664.
Hs.655109.

3D structure databases

ProteinModelPortaliQ96K75.
SMRiQ96K75.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124319. 1 interactor.
IntActiQ96K75. 1 interactor.
STRINGi9606.ENSP00000295208.

PTM databases

iPTMnetiQ96K75.
PhosphoSitePlusiQ96K75.

Polymorphism and mutation databases

BioMutaiZNF514.
DMDMi42560003.

Proteomic databases

EPDiQ96K75.
PaxDbiQ96K75.
PeptideAtlasiQ96K75.
PRIDEiQ96K75.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000295208; ENSP00000295208; ENSG00000144026.
ENST00000411425; ENSP00000405509; ENSG00000144026.
GeneIDi84874.
KEGGihsa:84874.
UCSCiuc002sue.2. human.

Organism-specific databases

CTDi84874.
GeneCardsiZNF514.
HGNCiHGNC:25894. ZNF514.
HPAiHPA028974.
neXtProtiNX_Q96K75.
OpenTargetsiENSG00000144026.
PharmGKBiPA134978837.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129852.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ96K75.
KOiK09228.
OMAiCDTEFRQ.
OrthoDBiEOG091G02KC.
PhylomeDBiQ96K75.
TreeFamiTF337055.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000144026-MONOMER.
ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

ChiTaRSiZNF514. human.
GenomeRNAii84874.
PROiQ96K75.

Gene expression databases

BgeeiENSG00000144026.
CleanExiHS_ZNF514.
ExpressionAtlasiQ96K75. baseline and differential.
GenevisibleiQ96K75. HS.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 7 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 5 hits.
PF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 7 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 7 hits.
PS50157. ZINC_FINGER_C2H2_2. 7 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZN514_HUMAN
AccessioniPrimary (citable) accession number: Q96K75
Secondary accession number(s): Q5JPJ3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 16, 2004
Last sequence update: December 1, 2001
Last modified: November 2, 2016
This is version 130 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.