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Protein

Zinc finger protein 514

Gene

ZNF514

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri204 – 226C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri232 – 254C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri260 – 282C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri288 – 310C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri316 – 338C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri344 – 366C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri372 – 394C2H2-type 7PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 514
Gene namesi
Name:ZNF514
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000144026.11
HGNCiHGNC:25894 ZNF514
neXtProtiNX_Q96K75

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000144026
PharmGKBiPA134978837

Polymorphism and mutation databases

BioMutaiZNF514
DMDMi42560003

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000476331 – 400Zinc finger protein 514Add BLAST400

Proteomic databases

EPDiQ96K75
PaxDbiQ96K75
PeptideAtlasiQ96K75
PRIDEiQ96K75
ProteomicsDBi77046

PTM databases

iPTMnetiQ96K75
PhosphoSitePlusiQ96K75

Expressioni

Gene expression databases

BgeeiENSG00000144026
CleanExiHS_ZNF514
ExpressionAtlasiQ96K75 baseline and differential
GenevisibleiQ96K75 HS

Organism-specific databases

HPAiHPA028974

Interactioni

Protein-protein interaction databases

BioGridi124319, 9 interactors
IntActiQ96K75, 1 interactor
STRINGi9606.ENSP00000295208

Structurei

3D structure databases

ProteinModelPortaliQ96K75
SMRiQ96K75
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 72KRABPROSITE-ProRule annotationAdd BLAST72

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri204 – 226C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri232 – 254C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri260 – 282C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri288 – 310C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri316 – 338C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri344 – 366C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri372 – 394C2H2-type 7PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00910000144215
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiQ96K75
KOiK09228
OMAiCDTEFRQ
OrthoDBiEOG091G02KC
PhylomeDBiQ96K75
TreeFamiTF337055

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 7 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 4 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 7 hits
PS50157 ZINC_FINGER_C2H2_2, 7 hits

Sequencei

Sequence statusi: Complete.

Q96K75-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTFEDVAVEF SQWEWGQLNP AQKDLYREVM LENFRNLAIL GLLVSKPYVI
60 70 80 90 100
CQLEEGGEPF MVEREISTGA HSDWKRRSKS KESMPSWGIS KEELFQVVSV
110 120 130 140 150
EKHIQDVLQF SKLKAACGCD GQLEMQQIKQ ERHLKQMSTI HKSATTLSRD
160 170 180 190 200
YKWNGFGRSL GLRSVLVNQH SILMGEGSYK CDTEFRQTLG GNNSQRTHPE
210 220 230 240 250
KKSCKCNECG KSFHFQSELR RHQRCHTGEK PYECSDCGRA FGHISSLIKH
260 270 280 290 300
QRTHTGEKPY ECSECGRAFS QSSSLVLHYR FHTGEKPYKC NECGRAFGHT
310 320 330 340 350
SSLIKHQRTH TGEKPYECRE CGRTFSQSSS LIVHYRFHTG EKPYKCNKCG
360 370 380 390 400
RAFSQSSSLT QHYRFHTGEK PYKCNECGRA FAHTASLIKH QRSHAGKKTL
Length:400
Mass (Da):45,938
Last modified:December 1, 2001 - v1
Checksum:i7BD27F892ABE3FF8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK027363 mRNA Translation: BAB55064.1
AL832263 mRNA Translation: CAI46170.1
AC092835 Genomic DNA Translation: AAX88981.1
BC074900 mRNA Translation: AAH74900.1
BC074901 mRNA Translation: AAH74901.1
BC110524 mRNA Translation: AAI10525.1
BC110525 mRNA Translation: AAI10526.1
CCDSiCCDS2011.1
RefSeqiNP_001304934.1, NM_001318005.1
NP_116177.1, NM_032788.2
XP_006712869.1, XM_006712806.2
UniGeneiHs.355664
Hs.655109

Genome annotation databases

EnsembliENST00000295208; ENSP00000295208; ENSG00000144026
ENST00000411425; ENSP00000405509; ENSG00000144026
GeneIDi84874
KEGGihsa:84874
UCSCiuc002sue.2 human

Similar proteinsi

Entry informationi

Entry nameiZN514_HUMAN
AccessioniPrimary (citable) accession number: Q96K75
Secondary accession number(s): Q5JPJ3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 16, 2004
Last sequence update: December 1, 2001
Last modified: June 20, 2018
This is version 142 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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