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Protein

Zinc finger and BTB domain-containing protein 45

Gene

ZBTB45

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri403 – 425C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri431 – 453C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri459 – 481C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri486 – 508C2H2-type 4PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:ENSG00000119574-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger and BTB domain-containing protein 45
Alternative name(s):
Zinc finger protein 499
Gene namesi
Name:ZBTB45
Synonyms:ZNF499
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:23715. ZBTB45.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000119574.
PharmGKBiPA162409464.

Polymorphism and mutation databases

BioMutaiZBTB45.
DMDMi45477325.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000476191 – 511Zinc finger and BTB domain-containing protein 45Add BLAST511

Proteomic databases

EPDiQ96K62.
PaxDbiQ96K62.
PeptideAtlasiQ96K62.
PRIDEiQ96K62.

PTM databases

iPTMnetiQ96K62.
PhosphoSitePlusiQ96K62.

Expressioni

Gene expression databases

BgeeiENSG00000119574.
CleanExiHS_ZBTB45.
ExpressionAtlasiQ96K62. baseline and differential.
GenevisibleiQ96K62. HS.

Organism-specific databases

HPAiHPA035754.

Interactioni

Protein-protein interaction databases

BioGridi124322. 1 interactor.
DIPiDIP-62048N.
IntActiQ96K62. 4 interactors.
MINTiMINT-1418836.
STRINGi9606.ENSP00000346603.

Structurei

3D structure databases

ProteinModelPortaliQ96K62.
SMRiQ96K62.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini33 – 96BTBPROSITE-ProRule annotationAdd BLAST64

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi128 – 197Pro-richAdd BLAST70
Compositional biasi299 – 401Pro-richAdd BLAST103

Sequence similaritiesi

Contains 1 BTB (POZ) domain.PROSITE-ProRule annotation
Contains 4 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri403 – 425C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri431 – 453C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri459 – 481C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri486 – 508C2H2-type 4PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00760000119063.
HOGENOMiHOG000136747.
HOVERGENiHBG060183.
InParanoidiQ96K62.
KOiK10516.
OMAiAPPDCVL.
OrthoDBiEOG091G0EMJ.
PhylomeDBiQ96K62.
TreeFamiTF335684.

Family and domain databases

Gene3Di3.30.160.60. 3 hits.
InterProiIPR000210. BTB/POZ_dom.
IPR011333. SKP1/BTB/POZ.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00651. BTB. 1 hit.
PF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTiSM00225. BTB. 1 hit.
SM00355. ZnF_C2H2. 4 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 4 hits.
PS50157. ZINC_FINGER_C2H2_2. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96K62-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAAEAVHHI HLQNFSRSLL ETLNGQRLGG HFCDVTVRIR EASLRAHRCV
60 70 80 90 100
LAAGSPFFQD KLLLGHSEIR VPPVVPAQTV RQLVEFLYSG SLVVAQGEAL
110 120 130 140 150
QVLTAASVLR IQTVIDECTQ IIARARAPGT SAPTPLPTPV PPPLAPAQLR
160 170 180 190 200
HRLRHLLAAR PPGHPGAAHS RKQRQPARLQ LPAPPTPAKA EGPDADPSLS
210 220 230 240 250
AAPDDRGDED DEESDDETDG EDGEGGGPGE GQAPPSFPDC AAGFLTAAAD
260 270 280 290 300
SACEEPPAPT GLADYSGAGR DFLRGAGSAE DVFPDSYVST WHDEDGAVPE
310 320 330 340 350
GCPTETPVQP DCILSGSRPP GVKTPGPPVA LFPFHLGAPG PPAPPPSAPS
360 370 380 390 400
GPAPAPPPAF YPTLQPEAAP STQLGEVPAP SAAPTTAPSG TPARTPGAEP
410 420 430 440 450
PTYECSHCRK TFSSRKNYTK HMFIHSGEKP HQCAVCWRSF SLRDYLLKHM
460 470 480 490 500
VTHTGVRAFQ CAVCAKRFTQ KSSLNVHMRT HRPERAPCPA CGKVFSHRAL
510
LERHLAAHPA P
Length:511
Mass (Da):54,008
Last modified:December 1, 2001 - v1
Checksum:i6E691746C51CB988
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_052924293D → E.Corresponds to variant rs35430780dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK027392 mRNA. Translation: BAB55079.1.
BC024738 mRNA. Translation: AAH24738.1.
CCDSiCCDS12984.1.
RefSeqiNP_001303907.1. NM_001316978.1.
NP_001303908.1. NM_001316979.1.
NP_001303909.1. NM_001316980.1.
NP_001303910.1. NM_001316981.1.
NP_001303911.1. NM_001316982.1.
NP_116181.1. NM_032792.3.
XP_006723508.1. XM_006723445.3.
UniGeneiHs.515662.

Genome annotation databases

EnsembliENST00000354590; ENSP00000346603; ENSG00000119574.
ENST00000594051; ENSP00000469089; ENSG00000119574.
ENST00000600990; ENSP00000473072; ENSG00000119574.
GeneIDi84878.
KEGGihsa:84878.
UCSCiuc002qtd.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK027392 mRNA. Translation: BAB55079.1.
BC024738 mRNA. Translation: AAH24738.1.
CCDSiCCDS12984.1.
RefSeqiNP_001303907.1. NM_001316978.1.
NP_001303908.1. NM_001316979.1.
NP_001303909.1. NM_001316980.1.
NP_001303910.1. NM_001316981.1.
NP_001303911.1. NM_001316982.1.
NP_116181.1. NM_032792.3.
XP_006723508.1. XM_006723445.3.
UniGeneiHs.515662.

3D structure databases

ProteinModelPortaliQ96K62.
SMRiQ96K62.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124322. 1 interactor.
DIPiDIP-62048N.
IntActiQ96K62. 4 interactors.
MINTiMINT-1418836.
STRINGi9606.ENSP00000346603.

PTM databases

iPTMnetiQ96K62.
PhosphoSitePlusiQ96K62.

Polymorphism and mutation databases

BioMutaiZBTB45.
DMDMi45477325.

Proteomic databases

EPDiQ96K62.
PaxDbiQ96K62.
PeptideAtlasiQ96K62.
PRIDEiQ96K62.

Protocols and materials databases

DNASUi84878.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000354590; ENSP00000346603; ENSG00000119574.
ENST00000594051; ENSP00000469089; ENSG00000119574.
ENST00000600990; ENSP00000473072; ENSG00000119574.
GeneIDi84878.
KEGGihsa:84878.
UCSCiuc002qtd.3. human.

Organism-specific databases

CTDi84878.
GeneCardsiZBTB45.
HGNCiHGNC:23715. ZBTB45.
HPAiHPA035754.
neXtProtiNX_Q96K62.
OpenTargetsiENSG00000119574.
PharmGKBiPA162409464.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00760000119063.
HOGENOMiHOG000136747.
HOVERGENiHBG060183.
InParanoidiQ96K62.
KOiK10516.
OMAiAPPDCVL.
OrthoDBiEOG091G0EMJ.
PhylomeDBiQ96K62.
TreeFamiTF335684.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000119574-MONOMER.

Miscellaneous databases

ChiTaRSiZBTB45. human.
GenomeRNAii84878.
PROiQ96K62.

Gene expression databases

BgeeiENSG00000119574.
CleanExiHS_ZBTB45.
ExpressionAtlasiQ96K62. baseline and differential.
GenevisibleiQ96K62. HS.

Family and domain databases

Gene3Di3.30.160.60. 3 hits.
InterProiIPR000210. BTB/POZ_dom.
IPR011333. SKP1/BTB/POZ.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00651. BTB. 1 hit.
PF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTiSM00225. BTB. 1 hit.
SM00355. ZnF_C2H2. 4 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 4 hits.
PS50157. ZINC_FINGER_C2H2_2. 4 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZBT45_HUMAN
AccessioniPrimary (citable) accession number: Q96K62
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2004
Last sequence update: December 1, 2001
Last modified: November 30, 2016
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.