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Protein

Zinc finger and BTB domain-containing protein 45

Gene

ZBTB45

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri403 – 42523C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri431 – 45323C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri459 – 48123C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri486 – 50823C2H2-type 4PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger and BTB domain-containing protein 45
Alternative name(s):
Zinc finger protein 499
Gene namesi
Name:ZBTB45
Synonyms:ZNF499
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:23715. ZBTB45.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162409464.

Polymorphism and mutation databases

BioMutaiZBTB45.
DMDMi45477325.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 511511Zinc finger and BTB domain-containing protein 45PRO_0000047619Add
BLAST

Proteomic databases

PaxDbiQ96K62.
PRIDEiQ96K62.

Expressioni

Gene expression databases

BgeeiQ96K62.
CleanExiHS_ZBTB45.
ExpressionAtlasiQ96K62. baseline and differential.
GenevisibleiQ96K62. HS.

Organism-specific databases

HPAiHPA035754.

Interactioni

Protein-protein interaction databases

BioGridi124322. 1 interaction.
IntActiQ96K62. 2 interactions.
MINTiMINT-1418836.
STRINGi9606.ENSP00000346603.

Structurei

3D structure databases

ProteinModelPortaliQ96K62.
SMRiQ96K62. Positions 16-118, 394-508.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini33 – 9664BTBPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi128 – 19770Pro-richAdd
BLAST
Compositional biasi299 – 401103Pro-richAdd
BLAST

Sequence similaritiesi

Contains 1 BTB (POZ) domain.PROSITE-ProRule annotation
Contains 4 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri403 – 42523C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri431 – 45323C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri459 – 48123C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri486 – 50823C2H2-type 4PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00760000119063.
HOGENOMiHOG000136747.
HOVERGENiHBG060183.
InParanoidiQ96K62.
KOiK10516.
OMAiEQPAYEC.
OrthoDBiEOG7RJPRD.
PhylomeDBiQ96K62.
TreeFamiTF335684.

Family and domain databases

Gene3Di3.30.160.60. 3 hits.
InterProiIPR000210. BTB/POZ_dom.
IPR011333. SKP1/BTB/POZ.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00651. BTB. 1 hit.
PF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTiSM00225. BTB. 1 hit.
SM00355. ZnF_C2H2. 4 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 4 hits.
PS50157. ZINC_FINGER_C2H2_2. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96K62-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAAEAVHHI HLQNFSRSLL ETLNGQRLGG HFCDVTVRIR EASLRAHRCV
60 70 80 90 100
LAAGSPFFQD KLLLGHSEIR VPPVVPAQTV RQLVEFLYSG SLVVAQGEAL
110 120 130 140 150
QVLTAASVLR IQTVIDECTQ IIARARAPGT SAPTPLPTPV PPPLAPAQLR
160 170 180 190 200
HRLRHLLAAR PPGHPGAAHS RKQRQPARLQ LPAPPTPAKA EGPDADPSLS
210 220 230 240 250
AAPDDRGDED DEESDDETDG EDGEGGGPGE GQAPPSFPDC AAGFLTAAAD
260 270 280 290 300
SACEEPPAPT GLADYSGAGR DFLRGAGSAE DVFPDSYVST WHDEDGAVPE
310 320 330 340 350
GCPTETPVQP DCILSGSRPP GVKTPGPPVA LFPFHLGAPG PPAPPPSAPS
360 370 380 390 400
GPAPAPPPAF YPTLQPEAAP STQLGEVPAP SAAPTTAPSG TPARTPGAEP
410 420 430 440 450
PTYECSHCRK TFSSRKNYTK HMFIHSGEKP HQCAVCWRSF SLRDYLLKHM
460 470 480 490 500
VTHTGVRAFQ CAVCAKRFTQ KSSLNVHMRT HRPERAPCPA CGKVFSHRAL
510
LERHLAAHPA P
Length:511
Mass (Da):54,008
Last modified:December 1, 2001 - v1
Checksum:i6E691746C51CB988
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti293 – 2931D → E.
Corresponds to variant rs35430780 [ dbSNP | Ensembl ].
VAR_052924

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK027392 mRNA. Translation: BAB55079.1.
BC024738 mRNA. Translation: AAH24738.1.
CCDSiCCDS12984.1.
RefSeqiNP_001303907.1. NM_001316978.1.
NP_001303908.1. NM_001316979.1.
NP_001303909.1. NM_001316980.1.
NP_001303910.1. NM_001316981.1.
NP_001303911.1. NM_001316982.1.
NP_116181.1. NM_032792.3.
XP_006723508.1. XM_006723445.2.
UniGeneiHs.515662.

Genome annotation databases

EnsembliENST00000354590; ENSP00000346603; ENSG00000119574.
ENST00000594051; ENSP00000469089; ENSG00000119574.
ENST00000600990; ENSP00000473072; ENSG00000119574.
GeneIDi84878.
KEGGihsa:84878.
UCSCiuc002qtd.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK027392 mRNA. Translation: BAB55079.1.
BC024738 mRNA. Translation: AAH24738.1.
CCDSiCCDS12984.1.
RefSeqiNP_001303907.1. NM_001316978.1.
NP_001303908.1. NM_001316979.1.
NP_001303909.1. NM_001316980.1.
NP_001303910.1. NM_001316981.1.
NP_001303911.1. NM_001316982.1.
NP_116181.1. NM_032792.3.
XP_006723508.1. XM_006723445.2.
UniGeneiHs.515662.

3D structure databases

ProteinModelPortaliQ96K62.
SMRiQ96K62. Positions 16-118, 394-508.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124322. 1 interaction.
IntActiQ96K62. 2 interactions.
MINTiMINT-1418836.
STRINGi9606.ENSP00000346603.

Polymorphism and mutation databases

BioMutaiZBTB45.
DMDMi45477325.

Proteomic databases

PaxDbiQ96K62.
PRIDEiQ96K62.

Protocols and materials databases

DNASUi84878.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000354590; ENSP00000346603; ENSG00000119574.
ENST00000594051; ENSP00000469089; ENSG00000119574.
ENST00000600990; ENSP00000473072; ENSG00000119574.
GeneIDi84878.
KEGGihsa:84878.
UCSCiuc002qtd.3. human.

Organism-specific databases

CTDi84878.
GeneCardsiZBTB45.
HGNCiHGNC:23715. ZBTB45.
HPAiHPA035754.
neXtProtiNX_Q96K62.
PharmGKBiPA162409464.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00760000119063.
HOGENOMiHOG000136747.
HOVERGENiHBG060183.
InParanoidiQ96K62.
KOiK10516.
OMAiEQPAYEC.
OrthoDBiEOG7RJPRD.
PhylomeDBiQ96K62.
TreeFamiTF335684.

Miscellaneous databases

ChiTaRSiZBTB45. human.
GenomeRNAii84878.
NextBioi75185.
PROiQ96K62.

Gene expression databases

BgeeiQ96K62.
CleanExiHS_ZBTB45.
ExpressionAtlasiQ96K62. baseline and differential.
GenevisibleiQ96K62. HS.

Family and domain databases

Gene3Di3.30.160.60. 3 hits.
InterProiIPR000210. BTB/POZ_dom.
IPR011333. SKP1/BTB/POZ.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00651. BTB. 1 hit.
PF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTiSM00225. BTB. 1 hit.
SM00355. ZnF_C2H2. 4 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 4 hits.
PS50157. ZINC_FINGER_C2H2_2. 4 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Mammary gland.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Cervix.

Entry informationi

Entry nameiZBT45_HUMAN
AccessioniPrimary (citable) accession number: Q96K62
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2004
Last sequence update: December 1, 2001
Last modified: March 16, 2016
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.