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Protein

Zinc finger protein 668

Gene

ZNF668

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri22 – 4423C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri84 – 10623C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri112 – 13423C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri140 – 16223C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri168 – 19023C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri196 – 21823C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri224 – 24623C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri252 – 27423C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri280 – 30223C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri308 – 33023C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri336 – 35823C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri364 – 38623C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri392 – 41423C2H2-type 13PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri516 – 53823C2H2-type 14PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri544 – 56623C2H2-type 15PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri572 – 59423C2H2-type 16PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 668
Gene namesi
Name:ZNF668
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:25821. ZNF668.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142670515.

Polymorphism and mutation databases

BioMutaiZNF668.
DMDMi306526260.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 619619Zinc finger protein 668PRO_0000251478Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineCombined sources
Modified residuei387 – 3871PhosphoserineCombined sources

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ96K58.
MaxQBiQ96K58.
PaxDbiQ96K58.
PRIDEiQ96K58.

PTM databases

iPTMnetiQ96K58.
PhosphoSiteiQ96K58.

Expressioni

Gene expression databases

BgeeiQ96K58.
CleanExiHS_ZNF668.
ExpressionAtlasiQ96K58. baseline and differential.
GenevisibleiQ96K58. HS.

Organism-specific databases

HPAiHPA043048.

Interactioni

Protein-protein interaction databases

BioGridi122868. 32 interactions.
IntActiQ96K58. 13 interactions.
STRINGi9606.ENSP00000403975.

Structurei

3D structure databases

ProteinModelPortaliQ96K58.
SMRiQ96K58. Positions 15-423, 511-594.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 16 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri22 – 4423C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri84 – 10623C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri112 – 13423C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri140 – 16223C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri168 – 19023C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri196 – 21823C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri224 – 24623C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri252 – 27423C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri280 – 30223C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri308 – 33023C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri336 – 35823C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri364 – 38623C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri392 – 41423C2H2-type 13PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri516 – 53823C2H2-type 14PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri544 – 56623C2H2-type 15PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri572 – 59423C2H2-type 16PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ96K58.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ96K58.

Family and domain databases

Gene3Di3.30.160.60. 15 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF13912. zf-C2H2_6. 2 hits.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 16 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 16 hits.
PS50157. ZINC_FINGER_C2H2_2. 16 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96K58-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEVEAAEARS PAPGYKRSGR RYKCVSCTKT FPNAPRAARH AATHGPADCS
60 70 80 90 100
EEVAEVKPKP ETEAKAEEAS GEKVSGSAAK PRPYACPLCP KAYKTAPELR
110 120 130 140 150
SHGRSHTGEK PFPCPECGRR FMQPVCLRVH LASHAGELPF RCAHCPKAYG
160 170 180 190 200
ALSKLKIHQR GHTGERPYAC ADCGKSFADP SVFRKHRRTH AGLRPYSCER
210 220 230 240 250
CGKAYAELKD LRNHERSHTG ERPFLCSECG KSFSRSSSLT CHQRIHAAQK
260 270 280 290 300
PYRCPACGKG FTQLSSYQSH ERTHSGEKPF LCPRCGRMFS DPSSFRRHQR
310 320 330 340 350
AHEGVKPYHC EKCGKDFRQP ADLAMHRRVH TGDRPFKCLQ CDKTFVASWD
360 370 380 390 400
LKRHALVHSG QRPFRCEECG RAFAERASLT KHSRVHSGER PFHCNACGKS
410 420 430 440 450
FVVSSSLRKH ERTHRSSEAA GVPPAQELVV GLALPVGVAG ESSAAPAAGA
460 470 480 490 500
GLGDPPAGLL GLPPESGGVM ATQWQVVGMT VEHVECQDAG VREAPGPLEG
510 520 530 540 550
AGEAGGEEAD EKPPQFVCRE CKETFSTMTL LRRHERSHPE LRPFPCTQCG
560 570 580 590 600
KSFSDRAGLR KHSRTHSSVR PYTCPHCPKA FLSASDLRKH ERTHPVPMGT
610
PTPLEPLVAL LGMPEEGPA
Length:619
Mass (Da):67,890
Last modified:October 5, 2010 - v3
Checksum:iB86A2E15E9E7D7E8
GO
Isoform 2 (identifier: Q96K58-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MSEPGMLGRKDVWVPRETPFTKAM

Note: No experimental confirmation available. Gene prediction based on EST data.
Show »
Length:642
Mass (Da):70,505
Checksum:i186431601BBF0075
GO

Sequence cautioni

The sequence BAB14602.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAD92947.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti130 – 1301H → R in BAB14602 (PubMed:14702039).Curated
Sequence conflicti553 – 5531F → I in BAB55084 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti25 – 251V → L.3 Publications
Corresponds to variant rs2032917 [ dbSNP | Ensembl ].
VAR_027689
Natural varianti66 – 661A → T in a breast cancer sample; somatic mutation. 1 Publication
VAR_035595
Natural varianti286 – 2861G → S in a breast cancer sample; somatic mutation. 1 Publication
VAR_035596
Natural varianti304 – 3041G → E.1 Publication
Corresponds to variant rs17851949 [ dbSNP | Ensembl ].
VAR_027690
Natural varianti331 – 3311T → R in a breast cancer sample; somatic mutation. 1 Publication
VAR_035597
Natural varianti447 – 4471A → V.
Corresponds to variant rs8046978 [ dbSNP | Ensembl ].
VAR_027691
Natural varianti556 – 5561R → Q in a breast cancer sample; somatic mutation. 1 Publication
VAR_035598

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 11M → MSEPGMLGRKDVWVPRETPF TKAM in isoform 2. CuratedVSP_053786

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK023541 mRNA. Translation: BAB14602.1. Different initiation.
AK027398 mRNA. Translation: BAB55084.1.
AB209710 mRNA. Translation: BAD92947.2. Different initiation.
AC135050 Genomic DNA. No translation available.
BC021997 mRNA. Translation: AAH21997.1.
CCDSiCCDS10701.1. [Q96K58-1]
CCDS54003.1. [Q96K58-2]
RefSeqiNP_001166139.1. NM_001172668.1.
NP_001166140.1. NM_001172669.1.
NP_001166141.1. NM_001172670.1.
NP_078982.3. NM_024706.4.
UniGeneiHs.102928.

Genome annotation databases

EnsembliENST00000300849; ENSP00000300849; ENSG00000167394.
ENST00000394983; ENSP00000378434; ENSG00000167394.
ENST00000426488; ENSP00000403975; ENSG00000167394.
ENST00000535577; ENSP00000441349; ENSG00000167394.
ENST00000538906; ENSP00000440149; ENSG00000167394.
ENST00000539836; ENSP00000442573; ENSG00000167394.
GeneIDi79759.
KEGGihsa:79759.
UCSCiuc002eao.4. human. [Q96K58-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK023541 mRNA. Translation: BAB14602.1. Different initiation.
AK027398 mRNA. Translation: BAB55084.1.
AB209710 mRNA. Translation: BAD92947.2. Different initiation.
AC135050 Genomic DNA. No translation available.
BC021997 mRNA. Translation: AAH21997.1.
CCDSiCCDS10701.1. [Q96K58-1]
CCDS54003.1. [Q96K58-2]
RefSeqiNP_001166139.1. NM_001172668.1.
NP_001166140.1. NM_001172669.1.
NP_001166141.1. NM_001172670.1.
NP_078982.3. NM_024706.4.
UniGeneiHs.102928.

3D structure databases

ProteinModelPortaliQ96K58.
SMRiQ96K58. Positions 15-423, 511-594.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122868. 32 interactions.
IntActiQ96K58. 13 interactions.
STRINGi9606.ENSP00000403975.

PTM databases

iPTMnetiQ96K58.
PhosphoSiteiQ96K58.

Polymorphism and mutation databases

BioMutaiZNF668.
DMDMi306526260.

Proteomic databases

EPDiQ96K58.
MaxQBiQ96K58.
PaxDbiQ96K58.
PRIDEiQ96K58.

Protocols and materials databases

DNASUi79759.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000300849; ENSP00000300849; ENSG00000167394.
ENST00000394983; ENSP00000378434; ENSG00000167394.
ENST00000426488; ENSP00000403975; ENSG00000167394.
ENST00000535577; ENSP00000441349; ENSG00000167394.
ENST00000538906; ENSP00000440149; ENSG00000167394.
ENST00000539836; ENSP00000442573; ENSG00000167394.
GeneIDi79759.
KEGGihsa:79759.
UCSCiuc002eao.4. human. [Q96K58-1]

Organism-specific databases

CTDi79759.
GeneCardsiZNF668.
HGNCiHGNC:25821. ZNF668.
HPAiHPA043048.
neXtProtiNX_Q96K58.
PharmGKBiPA142670515.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ96K58.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ96K58.

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

ChiTaRSiZNF668. human.
GenomeRNAii79759.
NextBioi35486517.
PROiQ96K58.

Gene expression databases

BgeeiQ96K58.
CleanExiHS_ZNF668.
ExpressionAtlasiQ96K58. baseline and differential.
GenevisibleiQ96K58. HS.

Family and domain databases

Gene3Di3.30.160.60. 15 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF13912. zf-C2H2_6. 2 hits.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 16 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 16 hits.
PS50157. ZINC_FINGER_C2H2_2. 16 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT LEU-25.
    Tissue: Mammary gland and Placenta.
  2. Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F.
    Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT LEU-25.
    Tissue: Brain.
  3. "The sequence and analysis of duplication-rich human chromosome 16."
    Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.
    , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A.
    Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS LEU-25 AND GLU-304.
    Tissue: Skin.
  5. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-387, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  6. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. Cited for: VARIANTS [LARGE SCALE ANALYSIS] THR-66; SER-286; ARG-331 AND GLN-556.

Entry informationi

Entry nameiZN668_HUMAN
AccessioniPrimary (citable) accession number: Q96K58
Secondary accession number(s): C9JHH8
, F5H7E7, Q59EV1, Q8N669, Q9H8L4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: October 5, 2010
Last modified: May 11, 2016
This is version 120 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.