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Protein

Zinc finger protein 668

Gene

ZNF668

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri22 – 44C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri84 – 106C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri112 – 134C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri140 – 162C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri168 – 190C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri196 – 218C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri224 – 246C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri252 – 274C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri280 – 302C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri308 – 330C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri336 – 358C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri364 – 386C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri392 – 414C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri516 – 538C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri544 – 566C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri572 – 594C2H2-type 16PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 668
Gene namesi
Name:ZNF668
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:25821. ZNF668.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi79759.
PharmGKBiPA142670515.

Polymorphism and mutation databases

BioMutaiZNF668.
DMDMi306526260.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002514781 – 619Zinc finger protein 668Add BLAST619

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Modified residuei10PhosphoserineCombined sources1
Cross-linki57Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki59Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki65Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki80Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki154Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei387PhosphoserineCombined sources1
Cross-linki512Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ96K58.
MaxQBiQ96K58.
PaxDbiQ96K58.
PeptideAtlasiQ96K58.
PRIDEiQ96K58.

PTM databases

iPTMnetiQ96K58.
PhosphoSitePlusiQ96K58.

Expressioni

Gene expression databases

BgeeiENSG00000167394.
CleanExiHS_ZNF668.
ExpressionAtlasiQ96K58. baseline and differential.
GenevisibleiQ96K58. HS.

Organism-specific databases

HPAiHPA043048.

Interactioni

Protein-protein interaction databases

BioGridi122868. 34 interactors.
IntActiQ96K58. 18 interactors.
STRINGi9606.ENSP00000403975.

Structurei

3D structure databases

ProteinModelPortaliQ96K58.
SMRiQ96K58.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri22 – 44C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri84 – 106C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri112 – 134C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri140 – 162C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri168 – 190C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri196 – 218C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri224 – 246C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri252 – 274C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri280 – 302C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri308 – 330C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri336 – 358C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri364 – 386C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri392 – 414C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri516 – 538C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri544 – 566C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri572 – 594C2H2-type 16PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ96K58.
OrthoDBiEOG091G02KC.
PhylomeDBiQ96K58.

Family and domain databases

Gene3Di3.30.40.10. 3 hits.
InterProiView protein in InterPro
IPR013087. Znf_C2H2_type.
IPR013083. Znf_RING/FYVE/PHD.
SMARTiView protein in SMART
SM00355. ZnF_C2H2. 16 hits.
SUPFAMiSSF57667. SSF57667. 8 hits.
PROSITEiView protein in PROSITE
PS00028. ZINC_FINGER_C2H2_1. 16 hits.
PS50157. ZINC_FINGER_C2H2_2. 16 hits.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96K58-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEVEAAEARS PAPGYKRSGR RYKCVSCTKT FPNAPRAARH AATHGPADCS
60 70 80 90 100
EEVAEVKPKP ETEAKAEEAS GEKVSGSAAK PRPYACPLCP KAYKTAPELR
110 120 130 140 150
SHGRSHTGEK PFPCPECGRR FMQPVCLRVH LASHAGELPF RCAHCPKAYG
160 170 180 190 200
ALSKLKIHQR GHTGERPYAC ADCGKSFADP SVFRKHRRTH AGLRPYSCER
210 220 230 240 250
CGKAYAELKD LRNHERSHTG ERPFLCSECG KSFSRSSSLT CHQRIHAAQK
260 270 280 290 300
PYRCPACGKG FTQLSSYQSH ERTHSGEKPF LCPRCGRMFS DPSSFRRHQR
310 320 330 340 350
AHEGVKPYHC EKCGKDFRQP ADLAMHRRVH TGDRPFKCLQ CDKTFVASWD
360 370 380 390 400
LKRHALVHSG QRPFRCEECG RAFAERASLT KHSRVHSGER PFHCNACGKS
410 420 430 440 450
FVVSSSLRKH ERTHRSSEAA GVPPAQELVV GLALPVGVAG ESSAAPAAGA
460 470 480 490 500
GLGDPPAGLL GLPPESGGVM ATQWQVVGMT VEHVECQDAG VREAPGPLEG
510 520 530 540 550
AGEAGGEEAD EKPPQFVCRE CKETFSTMTL LRRHERSHPE LRPFPCTQCG
560 570 580 590 600
KSFSDRAGLR KHSRTHSSVR PYTCPHCPKA FLSASDLRKH ERTHPVPMGT
610
PTPLEPLVAL LGMPEEGPA
Length:619
Mass (Da):67,890
Last modified:October 5, 2010 - v3
Checksum:iB86A2E15E9E7D7E8
GO
Isoform 2 (identifier: Q96K58-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MSEPGMLGRKDVWVPRETPFTKAM

Note: No experimental confirmation available. Gene prediction based on EST data.
Show »
Length:642
Mass (Da):70,505
Checksum:i186431601BBF0075
GO

Sequence cautioni

The sequence BAB14602 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAD92947 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti130H → R in BAB14602 (PubMed:14702039).Curated1
Sequence conflicti553F → I in BAB55084 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02768925V → L3 PublicationsCorresponds to variant dbSNP:rs2032917Ensembl.1
Natural variantiVAR_03559566A → T in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_035596286G → S in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_027690304G → E1 PublicationCorresponds to variant dbSNP:rs17851949Ensembl.1
Natural variantiVAR_035597331T → R in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_027691447A → V. Corresponds to variant dbSNP:rs8046978Ensembl.1
Natural variantiVAR_035598556R → Q in a breast cancer sample; somatic mutation. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0537861M → MSEPGMLGRKDVWVPRETPF TKAM in isoform 2. Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK023541 mRNA. Translation: BAB14602.1. Different initiation.
AK027398 mRNA. Translation: BAB55084.1.
AB209710 mRNA. Translation: BAD92947.2. Different initiation.
AC135050 Genomic DNA. No translation available.
BC021997 mRNA. Translation: AAH21997.1.
CCDSiCCDS10701.1. [Q96K58-1]
CCDS54003.1. [Q96K58-2]
RefSeqiNP_001166139.1. NM_001172668.1.
NP_001166140.1. NM_001172669.1.
NP_001166141.1. NM_001172670.1.
NP_078982.3. NM_024706.4.
UniGeneiHs.102928.

Genome annotation databases

EnsembliENST00000300849; ENSP00000300849; ENSG00000167394.
ENST00000394983; ENSP00000378434; ENSG00000167394.
ENST00000426488; ENSP00000403975; ENSG00000167394.
ENST00000535577; ENSP00000441349; ENSG00000167394.
ENST00000538906; ENSP00000440149; ENSG00000167394.
ENST00000539836; ENSP00000442573; ENSG00000167394.
GeneIDi79759.
KEGGihsa:79759.
UCSCiuc002eao.4. human. [Q96K58-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiZN668_HUMAN
AccessioniPrimary (citable) accession number: Q96K58
Secondary accession number(s): C9JHH8
, F5H7E7, Q59EV1, Q8N669, Q9H8L4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: October 5, 2010
Last modified: August 30, 2017
This is version 130 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families