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Protein

Solute carrier family 35 member E1

Gene

SLC35E1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Putative transporter.By similarity

GO - Biological processi

  1. transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transport

Protein family/group databases

TCDBi2.A.7.9.9. the drug/metabolite transporter (dmt) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 35 member E1
Gene namesi
Name:SLC35E1
ORF Names:PSEC0038
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:20803. SLC35E1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei50 – 7021HelicalSequence AnalysisAdd
BLAST
Transmembranei111 – 13121HelicalSequence AnalysisAdd
BLAST
Transmembranei133 – 15321HelicalSequence AnalysisAdd
BLAST
Transmembranei165 – 18420HelicalSequence AnalysisAdd
BLAST
Transmembranei188 – 20720HelicalSequence AnalysisAdd
BLAST
Transmembranei222 – 24221HelicalSequence AnalysisAdd
BLAST
Transmembranei252 – 27423HelicalSequence AnalysisAdd
BLAST
Transmembranei282 – 30322HelicalSequence AnalysisAdd
BLAST
Transmembranei312 – 33221HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134916810.

Polymorphism and mutation databases

BioMutaiSLC35E1.
DMDMi172045863.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 410410Solute carrier family 35 member E1PRO_0000071941Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei363 – 3631Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ96K37.
PaxDbiQ96K37.
PRIDEiQ96K37.

PTM databases

PhosphoSiteiQ96K37.

Expressioni

Gene expression databases

BgeeiQ96K37.
CleanExiHS_SLC35E1.
ExpressionAtlasiQ96K37. baseline and differential.
GenevestigatoriQ96K37.

Organism-specific databases

HPAiHPA016570.

Interactioni

Protein-protein interaction databases

BioGridi123013. 4 interactions.
IntActiQ96K37. 4 interactions.
MINTiMINT-1431203.
STRINGi9606.ENSP00000387152.

Structurei

3D structure databases

ProteinModelPortaliQ96K37.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG312636.
GeneTreeiENSGT00530000063705.
HOGENOMiHOG000241297.
HOVERGENiHBG067079.
InParanoidiQ96K37.
KOiK15283.
OMAiANQQARR.
OrthoDBiEOG7X9G72.
PhylomeDBiQ96K37.
TreeFamiTF324822.

Family and domain databases

InterProiIPR000620. EamA_dom.
IPR004853. Tpt_PEP_trans_dom.
[Graphical view]
PfamiPF00892. EamA. 1 hit.
PF03151. TPT. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96K37-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAAAVGAGH GAGGPGAASS SGGAREGARV AALCLLWYAL SAGGNVVNKV
60 70 80 90 100
ILSAFPFPVT VSLCHILALC AGLPPLLRAW RVPPAPPVSG PGPSPHPSSG
110 120 130 140 150
PLLPPRFYPR YVLPLAFGKY FASVSAHVSI WKVPVSYAHT VKATMPIWVV
160 170 180 190 200
LLSRIIMKEK QSTKVYLSLI PIISGVLLAT VTELSFDMWG LVSALAATLC
210 220 230 240 250
FSLQNIFSKK VLRDSRIHHL RLLNILGCHA VFFMIPTWVL VDLSAFLVSS
260 270 280 290 300
DLTYVYQWPW TLLLLAVSGF CNFAQNVIAF SILNLVSPLS YSVANATKRI
310 320 330 340 350
MVITVSLIML RNPVTSTNVL GMMTAILGVF LYNKTKYDAN QQARKHLLPV
360 370 380 390 400
TTADLSSKER HRSPLEKPHN GLLFPQHGDY QYGRNNILTD HFQYSRQSYP
410
NSYSLNRYDV
Length:410
Mass (Da):44,773
Last modified:February 26, 2008 - v2
Checksum:i691D67A89A1D2114
GO
Isoform 2 (identifier: Q96K37-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-300: Missing.

Note: No experimental confirmation available.

Show »
Length:110
Mass (Da):12,701
Checksum:i76B981790DC73E2B
GO
Isoform 3 (identifier: Q96K37-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-156: Missing.
     253-260: TYVYQWPW → GLPSENVL
     261-410: Missing.

Note: No experimental confirmation available.

Show »
Length:104
Mass (Da):11,547
Checksum:i41E9411E9FC514ED
GO

Sequence cautioni

The sequence AAH14557.1 differs from that shown. Reason: Frameshift at positions 372 and 384. Curated
The sequence AAH62562.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence BAB55306.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence BAB55410.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence BAC11565.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti242 – 2421D → V in CAE45863 (PubMed:17974005).Curated
Sequence conflicti318 – 3181N → I in BAC11565 (PubMed:16303743).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 300300Missing in isoform 2. 1 PublicationVSP_010139Add
BLAST
Alternative sequencei1 – 156156Missing in isoform 3. 1 PublicationVSP_031351Add
BLAST
Alternative sequencei253 – 2608TYVYQWPW → GLPSENVL in isoform 3. 1 PublicationVSP_010140
Alternative sequencei261 – 410150Missing in isoform 3. 1 PublicationVSP_010141Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX640756 mRNA. Translation: CAE45863.1.
BC062562 mRNA. Translation: AAH62562.1. Different initiation.
BC014557 mRNA. Translation: AAH14557.1. Frameshift.
AK027699 mRNA. Translation: BAB55306.1. Different initiation.
AK027850 mRNA. Translation: BAB55410.1. Different initiation.
AK075355 mRNA. Translation: BAC11565.1. Different initiation.
CCDSiCCDS12346.2. [Q96K37-1]
RefSeqiNP_079157.3. NM_024881.4. [Q96K37-1]
UniGeneiHs.620596.

Genome annotation databases

EnsembliENST00000595753; ENSP00000470652; ENSG00000127526. [Q96K37-1]
GeneIDi79939.
KEGGihsa:79939.
UCSCiuc002nem.1. human. [Q96K37-1]

Polymorphism and mutation databases

BioMutaiSLC35E1.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX640756 mRNA. Translation: CAE45863.1.
BC062562 mRNA. Translation: AAH62562.1. Different initiation.
BC014557 mRNA. Translation: AAH14557.1. Frameshift.
AK027699 mRNA. Translation: BAB55306.1. Different initiation.
AK027850 mRNA. Translation: BAB55410.1. Different initiation.
AK075355 mRNA. Translation: BAC11565.1. Different initiation.
CCDSiCCDS12346.2. [Q96K37-1]
RefSeqiNP_079157.3. NM_024881.4. [Q96K37-1]
UniGeneiHs.620596.

3D structure databases

ProteinModelPortaliQ96K37.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123013. 4 interactions.
IntActiQ96K37. 4 interactions.
MINTiMINT-1431203.
STRINGi9606.ENSP00000387152.

Protein family/group databases

TCDBi2.A.7.9.9. the drug/metabolite transporter (dmt) superfamily.

PTM databases

PhosphoSiteiQ96K37.

Polymorphism and mutation databases

BioMutaiSLC35E1.
DMDMi172045863.

Proteomic databases

MaxQBiQ96K37.
PaxDbiQ96K37.
PRIDEiQ96K37.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000595753; ENSP00000470652; ENSG00000127526. [Q96K37-1]
GeneIDi79939.
KEGGihsa:79939.
UCSCiuc002nem.1. human. [Q96K37-1]

Organism-specific databases

CTDi79939.
GeneCardsiGC19M016660.
H-InvDBHIX0027455.
HGNCiHGNC:20803. SLC35E1.
HPAiHPA016570.
neXtProtiNX_Q96K37.
PharmGKBiPA134916810.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG312636.
GeneTreeiENSGT00530000063705.
HOGENOMiHOG000241297.
HOVERGENiHBG067079.
InParanoidiQ96K37.
KOiK15283.
OMAiANQQARR.
OrthoDBiEOG7X9G72.
PhylomeDBiQ96K37.
TreeFamiTF324822.

Miscellaneous databases

GenomeRNAii79939.
NextBioi69886.
PROiQ96K37.

Gene expression databases

BgeeiQ96K37.
CleanExiHS_SLC35E1.
ExpressionAtlasiQ96K37. baseline and differential.
GenevestigatoriQ96K37.

Family and domain databases

InterProiIPR000620. EamA_dom.
IPR004853. Tpt_PEP_trans_dom.
[Graphical view]
PfamiPF00892. EamA. 1 hit.
PF03151. TPT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Rectum tumor.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Ovary.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 64-410 (ISOFORM 1).
  4. "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries."
    Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J., Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S., Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y.
    , Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S., Isogai T.
    DNA Res. 12:117-126(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 182-410 (ISOFORM 1).
    Tissue: Teratocarcinoma.
  5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-363, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.

Entry informationi

Entry nameiS35E1_HUMAN
AccessioniPrimary (citable) accession number: Q96K37
Secondary accession number(s): Q8NBQ2, Q96JV7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: February 26, 2008
Last modified: April 29, 2015
This is version 104 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.