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Q96K37 (S35E1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 99. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Solute carrier family 35 member E1
Gene names
Name:SLC35E1
ORF Names:PSEC0038
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length410 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Putative transporter By similarity.

Subcellular location

Membrane; Multi-pass membrane protein Potential.

Sequence similarities

Belongs to the TPT transporter family. SLC35E subfamily.

Sequence caution

The sequence AAH14557.1 differs from that shown. Reason: Frameshift at positions 372 and 384.

The sequence AAH62562.1 differs from that shown. Reason: Erroneous initiation.

The sequence BAB55306.1 differs from that shown. Reason: Erroneous initiation.

The sequence BAB55410.1 differs from that shown. Reason: Erroneous initiation.

The sequence BAC11565.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Biological processTransport
   Cellular componentMembrane
   Coding sequence diversityAlternative splicing
   DomainTransmembrane
Transmembrane helix
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processtransport

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q96K37-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q96K37-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-300: Missing.
Note: No experimental confirmation available.
Isoform 3 (identifier: Q96K37-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-156: Missing.
     253-260: TYVYQWPW → GLPSENVL
     261-410: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 410410Solute carrier family 35 member E1
PRO_0000071941

Regions

Transmembrane50 – 7021Helical; Potential
Transmembrane111 – 13121Helical; Potential
Transmembrane133 – 15321Helical; Potential
Transmembrane165 – 18420Helical; Potential
Transmembrane188 – 20720Helical; Potential
Transmembrane222 – 24221Helical; Potential
Transmembrane252 – 27423Helical; Potential
Transmembrane282 – 30322Helical; Potential
Transmembrane312 – 33221Helical; Potential

Amino acid modifications

Modified residue3631Phosphoserine Ref.5

Natural variations

Alternative sequence1 – 300300Missing in isoform 2.
VSP_010139
Alternative sequence1 – 156156Missing in isoform 3.
VSP_031351
Alternative sequence253 – 2608TYVYQWPW → GLPSENVL in isoform 3.
VSP_010140
Alternative sequence261 – 410150Missing in isoform 3.
VSP_010141

Experimental info

Sequence conflict2421D → V in CAE45863. Ref.1
Sequence conflict3181N → I in BAC11565. Ref.4

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified February 26, 2008. Version 2.
Checksum: 691D67A89A1D2114

FASTA41044,773
        10         20         30         40         50         60 
MAAAAVGAGH GAGGPGAASS SGGAREGARV AALCLLWYAL SAGGNVVNKV ILSAFPFPVT 

        70         80         90        100        110        120 
VSLCHILALC AGLPPLLRAW RVPPAPPVSG PGPSPHPSSG PLLPPRFYPR YVLPLAFGKY 

       130        140        150        160        170        180 
FASVSAHVSI WKVPVSYAHT VKATMPIWVV LLSRIIMKEK QSTKVYLSLI PIISGVLLAT 

       190        200        210        220        230        240 
VTELSFDMWG LVSALAATLC FSLQNIFSKK VLRDSRIHHL RLLNILGCHA VFFMIPTWVL 

       250        260        270        280        290        300 
VDLSAFLVSS DLTYVYQWPW TLLLLAVSGF CNFAQNVIAF SILNLVSPLS YSVANATKRI 

       310        320        330        340        350        360 
MVITVSLIML RNPVTSTNVL GMMTAILGVF LYNKTKYDAN QQARKHLLPV TTADLSSKER 

       370        380        390        400        410 
HRSPLEKPHN GLLFPQHGDY QYGRNNILTD HFQYSRQSYP NSYSLNRYDV 

« Hide

Isoform 2 [UniParc].

Checksum: 76B981790DC73E2B
Show »

FASTA11012,701
Isoform 3 [UniParc].

Checksum: 41E9411E9FC514ED
Show »

FASTA10411,547

References

[1]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
Tissue: Rectum tumor.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
Tissue: Ovary.
[3]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 64-410 (ISOFORM 1).
[4]"Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries."
Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J., Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S., Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y. expand/collapse author list , Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S., Isogai T.
DNA Res. 12:117-126(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 182-410 (ISOFORM 1).
Tissue: Teratocarcinoma.
[5]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-363, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BX640756 mRNA. Translation: CAE45863.1.
BC062562 mRNA. Translation: AAH62562.1. Different initiation.
BC014557 mRNA. Translation: AAH14557.1. Frameshift.
AK027699 mRNA. Translation: BAB55306.1. Different initiation.
AK027850 mRNA. Translation: BAB55410.1. Different initiation.
AK075355 mRNA. Translation: BAC11565.1. Different initiation.
CCDSCCDS12346.2. [Q96K37-1]
RefSeqNP_079157.3. NM_024881.4. [Q96K37-1]
UniGeneHs.620596.

3D structure databases

ProteinModelPortalQ96K37.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid123013. 4 interactions.
IntActQ96K37. 4 interactions.
MINTMINT-1431203.
STRING9606.ENSP00000387152.

Protein family/group databases

TCDB2.A.7.9.9. the drug/metabolite transporter (dmt) superfamily.

PTM databases

PhosphoSiteQ96K37.

Polymorphism databases

DMDM172045863.

Proteomic databases

MaxQBQ96K37.
PaxDbQ96K37.
PRIDEQ96K37.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000431408; ENSP00000397670; ENSG00000127526. [Q96K37-3]
ENST00000595753; ENSP00000470652; ENSG00000127526. [Q96K37-1]
GeneID79939.
KEGGhsa:79939.
UCSCuc002nem.1. human. [Q96K37-1]

Organism-specific databases

CTD79939.
GeneCardsGC19M016660.
H-InvDBHIX0027455.
HGNCHGNC:20803. SLC35E1.
HPAHPA016570.
neXtProtNX_Q96K37.
PharmGKBPA134916810.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG312636.
HOGENOMHOG000241297.
HOVERGENHBG067079.
InParanoidQ96K37.
KOK15283.
OMAPLEKPHN.
OrthoDBEOG7X9G72.
PhylomeDBQ96K37.
TreeFamTF324822.

Gene expression databases

ArrayExpressQ96K37.
BgeeQ96K37.
CleanExHS_SLC35E1.
GenevestigatorQ96K37.

Family and domain databases

InterProIPR000620. DMT.
IPR004853. Tpt_PEP_trans_dom.
[Graphical view]
PfamPF00892. EamA. 1 hit.
PF03151. TPT. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi79939.
NextBio69886.
PROQ96K37.

Entry information

Entry nameS35E1_HUMAN
AccessionPrimary (citable) accession number: Q96K37
Secondary accession number(s): Q8NBQ2, Q96JV7
Entry history
Integrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: February 26, 2008
Last modified: July 9, 2014
This is version 99 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM