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Q96K37

- S35E1_HUMAN

UniProt

Q96K37 - S35E1_HUMAN

Protein

Solute carrier family 35 member E1

Gene

SLC35E1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 100 (01 Oct 2014)
      Sequence version 2 (26 Feb 2008)
      Previous versions | rss
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    Functioni

    Putative transporter.By similarity

    GO - Biological processi

    1. transport Source: UniProtKB-KW

    Keywords - Biological processi

    Transport

    Protein family/group databases

    TCDBi2.A.7.9.9. the drug/metabolite transporter (dmt) superfamily.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Solute carrier family 35 member E1
    Gene namesi
    Name:SLC35E1
    ORF Names:PSEC0038
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:20803. SLC35E1.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134916810.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 410410Solute carrier family 35 member E1PRO_0000071941Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei363 – 3631Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ96K37.
    PaxDbiQ96K37.
    PRIDEiQ96K37.

    PTM databases

    PhosphoSiteiQ96K37.

    Expressioni

    Gene expression databases

    ArrayExpressiQ96K37.
    BgeeiQ96K37.
    CleanExiHS_SLC35E1.
    GenevestigatoriQ96K37.

    Organism-specific databases

    HPAiHPA016570.

    Interactioni

    Protein-protein interaction databases

    BioGridi123013. 4 interactions.
    IntActiQ96K37. 4 interactions.
    MINTiMINT-1431203.
    STRINGi9606.ENSP00000387152.

    Structurei

    3D structure databases

    ProteinModelPortaliQ96K37.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei50 – 7021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei111 – 13121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei133 – 15321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei165 – 18420HelicalSequence AnalysisAdd
    BLAST
    Transmembranei188 – 20720HelicalSequence AnalysisAdd
    BLAST
    Transmembranei222 – 24221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei252 – 27423HelicalSequence AnalysisAdd
    BLAST
    Transmembranei282 – 30322HelicalSequence AnalysisAdd
    BLAST
    Transmembranei312 – 33221HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG312636.
    HOGENOMiHOG000241297.
    HOVERGENiHBG067079.
    InParanoidiQ96K37.
    KOiK15283.
    OMAiPLEKPHN.
    OrthoDBiEOG7X9G72.
    PhylomeDBiQ96K37.
    TreeFamiTF324822.

    Family and domain databases

    InterProiIPR000620. DMT.
    IPR004853. Tpt_PEP_trans_dom.
    [Graphical view]
    PfamiPF00892. EamA. 1 hit.
    PF03151. TPT. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q96K37-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAAAAVGAGH GAGGPGAASS SGGAREGARV AALCLLWYAL SAGGNVVNKV    50
    ILSAFPFPVT VSLCHILALC AGLPPLLRAW RVPPAPPVSG PGPSPHPSSG 100
    PLLPPRFYPR YVLPLAFGKY FASVSAHVSI WKVPVSYAHT VKATMPIWVV 150
    LLSRIIMKEK QSTKVYLSLI PIISGVLLAT VTELSFDMWG LVSALAATLC 200
    FSLQNIFSKK VLRDSRIHHL RLLNILGCHA VFFMIPTWVL VDLSAFLVSS 250
    DLTYVYQWPW TLLLLAVSGF CNFAQNVIAF SILNLVSPLS YSVANATKRI 300
    MVITVSLIML RNPVTSTNVL GMMTAILGVF LYNKTKYDAN QQARKHLLPV 350
    TTADLSSKER HRSPLEKPHN GLLFPQHGDY QYGRNNILTD HFQYSRQSYP 400
    NSYSLNRYDV 410
    Length:410
    Mass (Da):44,773
    Last modified:February 26, 2008 - v2
    Checksum:i691D67A89A1D2114
    GO
    Isoform 2 (identifier: Q96K37-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-300: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:110
    Mass (Da):12,701
    Checksum:i76B981790DC73E2B
    GO
    Isoform 3 (identifier: Q96K37-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-156: Missing.
         253-260: TYVYQWPW → GLPSENVL
         261-410: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:104
    Mass (Da):11,547
    Checksum:i41E9411E9FC514ED
    GO

    Sequence cautioni

    The sequence AAH14557.1 differs from that shown. Reason: Frameshift at positions 372 and 384.
    The sequence AAH62562.1 differs from that shown. Reason: Erroneous initiation.
    The sequence BAB55306.1 differs from that shown. Reason: Erroneous initiation.
    The sequence BAB55410.1 differs from that shown. Reason: Erroneous initiation.
    The sequence BAC11565.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti242 – 2421D → V in CAE45863. (PubMed:17974005)Curated
    Sequence conflicti318 – 3181N → I in BAC11565. (PubMed:16303743)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 300300Missing in isoform 2. 1 PublicationVSP_010139Add
    BLAST
    Alternative sequencei1 – 156156Missing in isoform 3. 1 PublicationVSP_031351Add
    BLAST
    Alternative sequencei253 – 2608TYVYQWPW → GLPSENVL in isoform 3. 1 PublicationVSP_010140
    Alternative sequencei261 – 410150Missing in isoform 3. 1 PublicationVSP_010141Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX640756 mRNA. Translation: CAE45863.1.
    BC062562 mRNA. Translation: AAH62562.1. Different initiation.
    BC014557 mRNA. Translation: AAH14557.1. Frameshift.
    AK027699 mRNA. Translation: BAB55306.1. Different initiation.
    AK027850 mRNA. Translation: BAB55410.1. Different initiation.
    AK075355 mRNA. Translation: BAC11565.1. Different initiation.
    CCDSiCCDS12346.2. [Q96K37-1]
    RefSeqiNP_079157.3. NM_024881.4. [Q96K37-1]
    UniGeneiHs.620596.

    Genome annotation databases

    EnsembliENST00000595753; ENSP00000470652; ENSG00000127526. [Q96K37-1]
    GeneIDi79939.
    KEGGihsa:79939.
    UCSCiuc002nem.1. human. [Q96K37-1]

    Polymorphism databases

    DMDMi172045863.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX640756 mRNA. Translation: CAE45863.1 .
    BC062562 mRNA. Translation: AAH62562.1 . Different initiation.
    BC014557 mRNA. Translation: AAH14557.1 . Frameshift.
    AK027699 mRNA. Translation: BAB55306.1 . Different initiation.
    AK027850 mRNA. Translation: BAB55410.1 . Different initiation.
    AK075355 mRNA. Translation: BAC11565.1 . Different initiation.
    CCDSi CCDS12346.2. [Q96K37-1 ]
    RefSeqi NP_079157.3. NM_024881.4. [Q96K37-1 ]
    UniGenei Hs.620596.

    3D structure databases

    ProteinModelPortali Q96K37.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 123013. 4 interactions.
    IntActi Q96K37. 4 interactions.
    MINTi MINT-1431203.
    STRINGi 9606.ENSP00000387152.

    Protein family/group databases

    TCDBi 2.A.7.9.9. the drug/metabolite transporter (dmt) superfamily.

    PTM databases

    PhosphoSitei Q96K37.

    Polymorphism databases

    DMDMi 172045863.

    Proteomic databases

    MaxQBi Q96K37.
    PaxDbi Q96K37.
    PRIDEi Q96K37.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000595753 ; ENSP00000470652 ; ENSG00000127526 . [Q96K37-1 ]
    GeneIDi 79939.
    KEGGi hsa:79939.
    UCSCi uc002nem.1. human. [Q96K37-1 ]

    Organism-specific databases

    CTDi 79939.
    GeneCardsi GC19M016660.
    H-InvDB HIX0027455.
    HGNCi HGNC:20803. SLC35E1.
    HPAi HPA016570.
    neXtProti NX_Q96K37.
    PharmGKBi PA134916810.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG312636.
    HOGENOMi HOG000241297.
    HOVERGENi HBG067079.
    InParanoidi Q96K37.
    KOi K15283.
    OMAi PLEKPHN.
    OrthoDBi EOG7X9G72.
    PhylomeDBi Q96K37.
    TreeFami TF324822.

    Miscellaneous databases

    GenomeRNAii 79939.
    NextBioi 69886.
    PROi Q96K37.

    Gene expression databases

    ArrayExpressi Q96K37.
    Bgeei Q96K37.
    CleanExi HS_SLC35E1.
    Genevestigatori Q96K37.

    Family and domain databases

    InterProi IPR000620. DMT.
    IPR004853. Tpt_PEP_trans_dom.
    [Graphical view ]
    Pfami PF00892. EamA. 1 hit.
    PF03151. TPT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
      Tissue: Rectum tumor.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Ovary.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 64-410 (ISOFORM 1).
    4. "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries."
      Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J., Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S., Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y.
      , Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S., Isogai T.
      DNA Res. 12:117-126(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 182-410 (ISOFORM 1).
      Tissue: Teratocarcinoma.
    5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-363, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.

    Entry informationi

    Entry nameiS35E1_HUMAN
    AccessioniPrimary (citable) accession number: Q96K37
    Secondary accession number(s): Q8NBQ2, Q96JV7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 26, 2004
    Last sequence update: February 26, 2008
    Last modified: October 1, 2014
    This is version 100 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3