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Q96K37

- S35E1_HUMAN

UniProt

Q96K37 - S35E1_HUMAN

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Protein
Solute carrier family 35 member E1
Gene
SLC35E1, PSEC0038
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Putative transporter By similarity.

GO - Biological processi

  1. transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transport

Protein family/group databases

TCDBi2.A.7.9.9. the drug/metabolite transporter (dmt) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 35 member E1
Gene namesi
Name:SLC35E1
ORF Names:PSEC0038
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:20803. SLC35E1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei50 – 7021Helical; Reviewed prediction
Add
BLAST
Transmembranei111 – 13121Helical; Reviewed prediction
Add
BLAST
Transmembranei133 – 15321Helical; Reviewed prediction
Add
BLAST
Transmembranei165 – 18420Helical; Reviewed prediction
Add
BLAST
Transmembranei188 – 20720Helical; Reviewed prediction
Add
BLAST
Transmembranei222 – 24221Helical; Reviewed prediction
Add
BLAST
Transmembranei252 – 27423Helical; Reviewed prediction
Add
BLAST
Transmembranei282 – 30322Helical; Reviewed prediction
Add
BLAST
Transmembranei312 – 33221Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134916810.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 410410Solute carrier family 35 member E1
PRO_0000071941Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei363 – 3631Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ96K37.
PaxDbiQ96K37.
PRIDEiQ96K37.

PTM databases

PhosphoSiteiQ96K37.

Expressioni

Gene expression databases

ArrayExpressiQ96K37.
BgeeiQ96K37.
CleanExiHS_SLC35E1.
GenevestigatoriQ96K37.

Organism-specific databases

HPAiHPA016570.

Interactioni

Protein-protein interaction databases

BioGridi123013. 4 interactions.
IntActiQ96K37. 4 interactions.
MINTiMINT-1431203.
STRINGi9606.ENSP00000387152.

Structurei

3D structure databases

ProteinModelPortaliQ96K37.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG312636.
HOGENOMiHOG000241297.
HOVERGENiHBG067079.
InParanoidiQ96K37.
KOiK15283.
OMAiPLEKPHN.
OrthoDBiEOG7X9G72.
PhylomeDBiQ96K37.
TreeFamiTF324822.

Family and domain databases

InterProiIPR000620. DMT.
IPR004853. Tpt_PEP_trans_dom.
[Graphical view]
PfamiPF00892. EamA. 1 hit.
PF03151. TPT. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q96K37-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MAAAAVGAGH GAGGPGAASS SGGAREGARV AALCLLWYAL SAGGNVVNKV    50
ILSAFPFPVT VSLCHILALC AGLPPLLRAW RVPPAPPVSG PGPSPHPSSG 100
PLLPPRFYPR YVLPLAFGKY FASVSAHVSI WKVPVSYAHT VKATMPIWVV 150
LLSRIIMKEK QSTKVYLSLI PIISGVLLAT VTELSFDMWG LVSALAATLC 200
FSLQNIFSKK VLRDSRIHHL RLLNILGCHA VFFMIPTWVL VDLSAFLVSS 250
DLTYVYQWPW TLLLLAVSGF CNFAQNVIAF SILNLVSPLS YSVANATKRI 300
MVITVSLIML RNPVTSTNVL GMMTAILGVF LYNKTKYDAN QQARKHLLPV 350
TTADLSSKER HRSPLEKPHN GLLFPQHGDY QYGRNNILTD HFQYSRQSYP 400
NSYSLNRYDV 410
Length:410
Mass (Da):44,773
Last modified:February 26, 2008 - v2
Checksum:i691D67A89A1D2114
GO
Isoform 2 (identifier: Q96K37-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-300: Missing.

Note: No experimental confirmation available.

Show »
Length:110
Mass (Da):12,701
Checksum:i76B981790DC73E2B
GO
Isoform 3 (identifier: Q96K37-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-156: Missing.
     253-260: TYVYQWPW → GLPSENVL
     261-410: Missing.

Note: No experimental confirmation available.

Show »
Length:104
Mass (Da):11,547
Checksum:i41E9411E9FC514ED
GO

Sequence cautioni

The sequence AAH14557.1 differs from that shown. Reason: Frameshift at positions 372 and 384.
The sequence AAH62562.1 differs from that shown. Reason: Erroneous initiation.
The sequence BAB55306.1 differs from that shown. Reason: Erroneous initiation.
The sequence BAB55410.1 differs from that shown. Reason: Erroneous initiation.
The sequence BAC11565.1 differs from that shown. Reason: Erroneous initiation.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 300300Missing in isoform 2.
VSP_010139Add
BLAST
Alternative sequencei1 – 156156Missing in isoform 3.
VSP_031351Add
BLAST
Alternative sequencei253 – 2608TYVYQWPW → GLPSENVL in isoform 3.
VSP_010140
Alternative sequencei261 – 410150Missing in isoform 3.
VSP_010141Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti242 – 2421D → V in CAE45863. 1 Publication
Sequence conflicti318 – 3181N → I in BAC11565. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX640756 mRNA. Translation: CAE45863.1.
BC062562 mRNA. Translation: AAH62562.1. Different initiation.
BC014557 mRNA. Translation: AAH14557.1. Frameshift.
AK027699 mRNA. Translation: BAB55306.1. Different initiation.
AK027850 mRNA. Translation: BAB55410.1. Different initiation.
AK075355 mRNA. Translation: BAC11565.1. Different initiation.
CCDSiCCDS12346.2. [Q96K37-1]
RefSeqiNP_079157.3. NM_024881.4. [Q96K37-1]
UniGeneiHs.620596.

Genome annotation databases

EnsembliENST00000431408; ENSP00000397670; ENSG00000127526. [Q96K37-3]
ENST00000595753; ENSP00000470652; ENSG00000127526. [Q96K37-1]
GeneIDi79939.
KEGGihsa:79939.
UCSCiuc002nem.1. human. [Q96K37-1]

Polymorphism databases

DMDMi172045863.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX640756 mRNA. Translation: CAE45863.1 .
BC062562 mRNA. Translation: AAH62562.1 . Different initiation.
BC014557 mRNA. Translation: AAH14557.1 . Frameshift.
AK027699 mRNA. Translation: BAB55306.1 . Different initiation.
AK027850 mRNA. Translation: BAB55410.1 . Different initiation.
AK075355 mRNA. Translation: BAC11565.1 . Different initiation.
CCDSi CCDS12346.2. [Q96K37-1 ]
RefSeqi NP_079157.3. NM_024881.4. [Q96K37-1 ]
UniGenei Hs.620596.

3D structure databases

ProteinModelPortali Q96K37.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 123013. 4 interactions.
IntActi Q96K37. 4 interactions.
MINTi MINT-1431203.
STRINGi 9606.ENSP00000387152.

Protein family/group databases

TCDBi 2.A.7.9.9. the drug/metabolite transporter (dmt) superfamily.

PTM databases

PhosphoSitei Q96K37.

Polymorphism databases

DMDMi 172045863.

Proteomic databases

MaxQBi Q96K37.
PaxDbi Q96K37.
PRIDEi Q96K37.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000431408 ; ENSP00000397670 ; ENSG00000127526 . [Q96K37-3 ]
ENST00000595753 ; ENSP00000470652 ; ENSG00000127526 . [Q96K37-1 ]
GeneIDi 79939.
KEGGi hsa:79939.
UCSCi uc002nem.1. human. [Q96K37-1 ]

Organism-specific databases

CTDi 79939.
GeneCardsi GC19M016660.
H-InvDB HIX0027455.
HGNCi HGNC:20803. SLC35E1.
HPAi HPA016570.
neXtProti NX_Q96K37.
PharmGKBi PA134916810.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG312636.
HOGENOMi HOG000241297.
HOVERGENi HBG067079.
InParanoidi Q96K37.
KOi K15283.
OMAi PLEKPHN.
OrthoDBi EOG7X9G72.
PhylomeDBi Q96K37.
TreeFami TF324822.

Miscellaneous databases

GenomeRNAii 79939.
NextBioi 69886.
PROi Q96K37.

Gene expression databases

ArrayExpressi Q96K37.
Bgeei Q96K37.
CleanExi HS_SLC35E1.
Genevestigatori Q96K37.

Family and domain databases

InterProi IPR000620. DMT.
IPR004853. Tpt_PEP_trans_dom.
[Graphical view ]
Pfami PF00892. EamA. 1 hit.
PF03151. TPT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Rectum tumor.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Ovary.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 64-410 (ISOFORM 1).
  4. "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries."
    Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J., Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S., Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y.
    , Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S., Isogai T.
    DNA Res. 12:117-126(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 182-410 (ISOFORM 1).
    Tissue: Teratocarcinoma.
  5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-363, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.

Entry informationi

Entry nameiS35E1_HUMAN
AccessioniPrimary (citable) accession number: Q96K37
Secondary accession number(s): Q8NBQ2, Q96JV7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: February 26, 2008
Last modified: July 9, 2014
This is version 99 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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