Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

RBPJ-interacting and tubulin-associated protein 1

Gene

RITA1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Tubulin-binding protein that acts as a negative regulator of Notch signaling pathway. Shuttles between the cytoplasm and the nucleus and mediates the nuclear export of RBPJ/RBPSUH, thereby preventing the interaction between RBPJ/RBPSUH and NICD product of Notch proteins (Notch intracellular domain), leading to down-regulate Notch-mediated transcription. May play a role in neurogenesis.1 Publication

GO - Molecular functioni

  • tubulin binding Source: UniProtKB

GO - Biological processi

  • negative regulation of Notch signaling pathway Source: UniProtKB
  • negative regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  • neurogenesis Source: UniProtKB
  • Notch signaling pathway Source: UniProtKB-KW
  • nuclear export Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Neurogenesis, Notch signaling pathway

Enzyme and pathway databases

SIGNORiQ96K30.

Names & Taxonomyi

Protein namesi
Recommended name:
RBPJ-interacting and tubulin-associated protein 1
Alternative name(s):
RBPJ-interacting and tubulin-associated protein
Gene namesi
Name:RITA1
Synonyms:C12orf52, RITA
ORF Names:PSEC0043
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:25925. RITA1.

Subcellular locationi

GO - Cellular componenti

  • centrosome Source: UniProtKB
  • cytoplasm Source: UniProtKB
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi7L → A: Results in nuclear accumulation; when associated with A-12 and A-15. 1 Publication1
Mutagenesisi12M → A: Results in nuclear accumulation; when associated with A-7 and A-15. 1 Publication1
Mutagenesisi15L → A: Results in nuclear accumulation; when associated with A-7 and A-12. 1 Publication1
Mutagenesisi95 – 97RKK → AAA: Abolishes nuclear localization. 1 Publication3

Organism-specific databases

DisGeNETi84934.
OpenTargetsiENSG00000139405.
PharmGKBiPA143485381.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002944291 – 269RBPJ-interacting and tubulin-associated protein 1Add BLAST269

Proteomic databases

PaxDbiQ96K30.
PeptideAtlasiQ96K30.
PRIDEiQ96K30.

PTM databases

iPTMnetiQ96K30.
PhosphoSitePlusiQ96K30.

Expressioni

Gene expression databases

BgeeiENSG00000139405.
CleanExiHS_C12orf52.
ExpressionAtlasiQ96K30. baseline and differential.
GenevisibleiQ96K30. HS.

Organism-specific databases

HPAiHPA039094.
HPA039095.
HPA061531.

Interactioni

Subunit structurei

Interacts with RBPJ/RBPSUH.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
DCP1AQ9NPI63EBI-2836148,EBI-374238
GOLGA2Q083794EBI-2836148,EBI-618309
RBPJQ0633010EBI-2836148,EBI-632552

GO - Molecular functioni

  • tubulin binding Source: UniProtKB

Protein-protein interaction databases

BioGridi124368. 5 interactors.
IntActiQ96K30. 10 interactors.
MINTiMINT-8094325.
STRINGi9606.ENSP00000410395.

Structurei

3D structure databases

ProteinModelPortaliQ96K30.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni128 – 156Interaction with RBPJ/RBPSUH1 PublicationAdd BLAST29
Regioni156 – 269Interaction with tubulinAdd BLAST114

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi5 – 17Nuclear export signalAdd BLAST13
Motifi92 – 108Nuclear localization signalAdd BLAST17

Sequence similaritiesi

Belongs to the RITA family.Curated

Phylogenomic databases

eggNOGiENOG410IKKU. Eukaryota.
ENOG411251C. LUCA.
GeneTreeiENSGT00390000013005.
HOGENOMiHOG000111762.
HOVERGENiHBG101945.
InParanoidiQ96K30.
OMAiFDPPWVE.
OrthoDBiEOG091G0OOF.
PhylomeDBiQ96K30.
TreeFamiTF337291.

Family and domain databases

InterProiIPR031418. RITA1.
[Graphical view]
PfamiPF17066. RITA. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96K30-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKTPVELAVS GMQTLGLQHR CRGGYRVKAR TSYVDETLFG SPAGTRPTPP
60 70 80 90 100
DFDPPWVEKA NRTRGVGKEA SKALGAKGSC ETTPSRGSTP TLTPRKKNKY
110 120 130 140 150
RPISHTPSYC DESLFGSRSE GASFGAPRMA KGDAAKLRAL LWTPPPTPRG
160 170 180 190 200
SHSPRPREAP LRAIHPAGPS KTEPGPAADS QKLSMGGLHS SRPLKRGLSH
210 220 230 240 250
SLTHLNVPST GHPATSAPHT NGPQDLRPST SGVTFRSPLV TSRARSVSIS
260
VPSTPRRGGA TQKPKPPWK
Length:269
Mass (Da):28,619
Last modified:December 1, 2001 - v1
Checksum:i3F053E1454F60773
GO
Isoform 2 (identifier: Q96K30-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     161-177: LRAIHPAGPSKTEPGPA → VPPTQMGLRISGLPRQG
     178-269: Missing.

Note: No experimental confirmation available.
Show »
Length:177
Mass (Da):19,050
Checksum:i834FD0C7095AED0B
GO
Isoform 3 (identifier: Q96K30-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MLREPRKQGLAGRAHLLSPGTTGSM

Note: No experimental confirmation available. Gene prediction based on partial EST data.
Show »
Length:293
Mass (Da):31,135
Checksum:i0CCC65D03B9B6825
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti73A → S in BAG53956 (PubMed:14702039).Curated1
Sequence conflicti217A → V in BAD96628 (Ref. 2) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_050865113S → W.Corresponds to variant rs16942601dbSNPEnsembl.1
Natural variantiVAR_033175220T → K.Corresponds to variant rs34831139dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0556491M → MLREPRKQGLAGRAHLLSPG TTGSM in isoform 3. Curated1
Alternative sequenceiVSP_026636161 – 177LRAIH…EPGPA → VPPTQMGLRISGLPRQG in isoform 2. 1 PublicationAdd BLAST17
Alternative sequenceiVSP_026637178 – 269Missing in isoform 2. 1 PublicationAdd BLAST92

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK075358 mRNA. Translation: BAC11568.1.
AK027733 mRNA. Translation: BAB55328.1.
AK027741 mRNA. Translation: BAB55333.1.
AK123762 mRNA. Translation: BAG53956.1.
AK222908 mRNA. Translation: BAD96628.1.
AC089999 Genomic DNA. No translation available.
BC022092 mRNA. Translation: AAH22092.1.
CCDSiCCDS66473.1. [Q96K30-3]
CCDS9166.1. [Q96K30-1]
RefSeqiNP_001273144.1. NM_001286215.1. [Q96K30-3]
NP_116237.1. NM_032848.2. [Q96K30-1]
XP_005254029.1. XM_005253972.2. [Q96K30-1]
UniGeneiHs.524762.

Genome annotation databases

EnsembliENST00000548278; ENSP00000449841; ENSG00000139405. [Q96K30-1]
ENST00000549621; ENSP00000448289; ENSG00000139405. [Q96K30-1]
ENST00000552495; ENSP00000448680; ENSG00000139405. [Q96K30-3]
GeneIDi84934.
KEGGihsa:84934.
UCSCiuc001tur.2. human. [Q96K30-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK075358 mRNA. Translation: BAC11568.1.
AK027733 mRNA. Translation: BAB55328.1.
AK027741 mRNA. Translation: BAB55333.1.
AK123762 mRNA. Translation: BAG53956.1.
AK222908 mRNA. Translation: BAD96628.1.
AC089999 Genomic DNA. No translation available.
BC022092 mRNA. Translation: AAH22092.1.
CCDSiCCDS66473.1. [Q96K30-3]
CCDS9166.1. [Q96K30-1]
RefSeqiNP_001273144.1. NM_001286215.1. [Q96K30-3]
NP_116237.1. NM_032848.2. [Q96K30-1]
XP_005254029.1. XM_005253972.2. [Q96K30-1]
UniGeneiHs.524762.

3D structure databases

ProteinModelPortaliQ96K30.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124368. 5 interactors.
IntActiQ96K30. 10 interactors.
MINTiMINT-8094325.
STRINGi9606.ENSP00000410395.

PTM databases

iPTMnetiQ96K30.
PhosphoSitePlusiQ96K30.

Proteomic databases

PaxDbiQ96K30.
PeptideAtlasiQ96K30.
PRIDEiQ96K30.

Protocols and materials databases

DNASUi84934.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000548278; ENSP00000449841; ENSG00000139405. [Q96K30-1]
ENST00000549621; ENSP00000448289; ENSG00000139405. [Q96K30-1]
ENST00000552495; ENSP00000448680; ENSG00000139405. [Q96K30-3]
GeneIDi84934.
KEGGihsa:84934.
UCSCiuc001tur.2. human. [Q96K30-1]

Organism-specific databases

CTDi84934.
DisGeNETi84934.
GeneCardsiRITA1.
H-InvDBHIX0011019.
HGNCiHGNC:25925. RITA1.
HPAiHPA039094.
HPA039095.
HPA061531.
neXtProtiNX_Q96K30.
OpenTargetsiENSG00000139405.
PharmGKBiPA143485381.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IKKU. Eukaryota.
ENOG411251C. LUCA.
GeneTreeiENSGT00390000013005.
HOGENOMiHOG000111762.
HOVERGENiHBG101945.
InParanoidiQ96K30.
OMAiFDPPWVE.
OrthoDBiEOG091G0OOF.
PhylomeDBiQ96K30.
TreeFamiTF337291.

Enzyme and pathway databases

SIGNORiQ96K30.

Miscellaneous databases

GenomeRNAii84934.
PROiQ96K30.

Gene expression databases

BgeeiENSG00000139405.
CleanExiHS_C12orf52.
ExpressionAtlasiQ96K30. baseline and differential.
GenevisibleiQ96K30. HS.

Family and domain databases

InterProiIPR031418. RITA1.
[Graphical view]
PfamiPF17066. RITA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRITA1_HUMAN
AccessioniPrimary (citable) accession number: Q96K30
Secondary accession number(s): B3KVZ4
, C9JIN1, F8VRG5, Q53GM3, Q96K25
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: December 1, 2001
Last modified: November 2, 2016
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.