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Protein

Transcription factor BTF3 homolog 4

Gene

BTF3L4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor BTF3 homolog 4
Alternative name(s):
Basic transcription factor 3-like 4
Gene namesi
Name:BTF3L4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:30547. BTF3L4.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142672545.

Polymorphism and mutation databases

BioMutaiBTF3L4.
DMDMi74751972.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 158158Transcription factor BTF3 homolog 4PRO_0000213557Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei111 – 1111PhosphothreonineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ96K17.
MaxQBiQ96K17.
PaxDbiQ96K17.
PeptideAtlasiQ96K17.
PRIDEiQ96K17.
TopDownProteomicsiQ96K17-1. [Q96K17-1]
Q96K17-2. [Q96K17-2]

PTM databases

iPTMnetiQ96K17.
PhosphoSiteiQ96K17.

Expressioni

Gene expression databases

BgeeiQ96K17.
CleanExiHS_BTF3L4.
ExpressionAtlasiQ96K17. baseline and differential.
GenevisibleiQ96K17. HS.

Organism-specific databases

HPAiHPA067026.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
DKFZp451B226Q5HYH73EBI-6137496,EBI-10173842
TXLNAP402223EBI-6137496,EBI-359793

Protein-protein interaction databases

BioGridi124828. 26 interactions.
IntActiQ96K17. 3 interactions.
STRINGi9606.ENSP00000360664.

Structurei

3D structure databases

ProteinModelPortaliQ96K17.
SMRiQ96K17. Positions 48-113.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini33 – 9866NAC-A/BPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the NAC-beta family.Curated
Contains 1 NAC-A/B (NAC-alpha/beta) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG2240. Eukaryota.
ENOG4111JBG. LUCA.
GeneTreeiENSGT00390000006283.
HOGENOMiHOG000261245.
HOVERGENiHBG004906.
InParanoidiQ96K17.
KOiK01527.
OMAiFAITGHS.
OrthoDBiEOG7CVPXQ.
PhylomeDBiQ96K17.
TreeFamiTF317546.

Family and domain databases

InterProiIPR002715. Nas_poly-pep-assoc_cplx_dom.
[Graphical view]
PfamiPF01849. NAC. 1 hit.
[Graphical view]
SMARTiSM01407. NAC. 1 hit.
[Graphical view]
PROSITEiPS51151. NAC_AB. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96K17-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNQEKLAKLQ AQVRIGGKGT ARRKKKVVHR TATADDKKLQ SSLKKLAVNN
60 70 80 90 100
IAGIEEVNMI KDDGTVIHFN NPKVQASLSA NTFAITGHAE AKPITEMLPG
110 120 130 140 150
ILSQLGADSL TSLRKLAEQF PRQVLDSKAP KPEDIDEEDD DVPDLVENFD

EASKNEAN
Length:158
Mass (Da):17,271
Last modified:December 1, 2001 - v1
Checksum:i8C4AD058FB92D722
GO
Isoform 2 (identifier: Q96K17-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-58: Missing.

Show »
Length:100
Mass (Da):10,905
Checksum:iA4E7541ADCE3110B
GO
Isoform 3 (identifier: Q96K17-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     57-78: VNMIKDDGTVIHFNNPKVQASL → SWTVKHQNQKTLMRKMMMFQIL
     79-158: Missing.

Note: No experimental confirmation available.
Show »
Length:78
Mass (Da):8,933
Checksum:i996D4293B4F2E030
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 5858Missing in isoform 2. 1 PublicationVSP_044248Add
BLAST
Alternative sequencei57 – 7822VNMIK…VQASL → SWTVKHQNQKTLMRKMMMFQ IL in isoform 3. 1 PublicationVSP_045972Add
BLAST
Alternative sequencei79 – 15880Missing in isoform 3. 1 PublicationVSP_045973Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK027750 mRNA. Translation: BAB55342.1.
AK027582 mRNA. Translation: BAG51353.1.
AL139156, AL445685 Genomic DNA. Translation: CAI22856.1.
AL445685, AL139156 Genomic DNA. Translation: CAI17032.1.
AL606761 Genomic DNA. No translation available.
CH471059 Genomic DNA. Translation: EAX06795.1.
CH471059 Genomic DNA. Translation: EAX06796.1.
CH471059 Genomic DNA. Translation: EAX06797.1.
CH471059 Genomic DNA. Translation: EAX06798.1.
CH471059 Genomic DNA. Translation: EAX06799.1.
BC022371 mRNA. Translation: AAH22371.1.
BC070378 mRNA. Translation: AAH70378.1.
BG536292 mRNA. No translation available.
CCDSiCCDS30713.1. [Q96K17-1]
CCDS44146.1. [Q96K17-2]
CCDS58001.1. [Q96K17-3]
RefSeqiNP_001129969.1. NM_001136497.2. [Q96K17-2]
NP_001230696.1. NM_001243767.1. [Q96K17-3]
NP_689478.1. NM_152265.4. [Q96K17-1]
UniGeneiHs.429839.

Genome annotation databases

EnsembliENST00000313334; ENSP00000360664; ENSG00000134717. [Q96K17-1]
ENST00000472944; ENSP00000436712; ENSG00000134717. [Q96K17-2]
ENST00000489308; ENSP00000434824; ENSG00000134717. [Q96K17-3]
GeneIDi91408.
KEGGihsa:91408.
UCSCiuc001ctk.4. human. [Q96K17-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK027750 mRNA. Translation: BAB55342.1.
AK027582 mRNA. Translation: BAG51353.1.
AL139156, AL445685 Genomic DNA. Translation: CAI22856.1.
AL445685, AL139156 Genomic DNA. Translation: CAI17032.1.
AL606761 Genomic DNA. No translation available.
CH471059 Genomic DNA. Translation: EAX06795.1.
CH471059 Genomic DNA. Translation: EAX06796.1.
CH471059 Genomic DNA. Translation: EAX06797.1.
CH471059 Genomic DNA. Translation: EAX06798.1.
CH471059 Genomic DNA. Translation: EAX06799.1.
BC022371 mRNA. Translation: AAH22371.1.
BC070378 mRNA. Translation: AAH70378.1.
BG536292 mRNA. No translation available.
CCDSiCCDS30713.1. [Q96K17-1]
CCDS44146.1. [Q96K17-2]
CCDS58001.1. [Q96K17-3]
RefSeqiNP_001129969.1. NM_001136497.2. [Q96K17-2]
NP_001230696.1. NM_001243767.1. [Q96K17-3]
NP_689478.1. NM_152265.4. [Q96K17-1]
UniGeneiHs.429839.

3D structure databases

ProteinModelPortaliQ96K17.
SMRiQ96K17. Positions 48-113.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124828. 26 interactions.
IntActiQ96K17. 3 interactions.
STRINGi9606.ENSP00000360664.

PTM databases

iPTMnetiQ96K17.
PhosphoSiteiQ96K17.

Polymorphism and mutation databases

BioMutaiBTF3L4.
DMDMi74751972.

Proteomic databases

EPDiQ96K17.
MaxQBiQ96K17.
PaxDbiQ96K17.
PeptideAtlasiQ96K17.
PRIDEiQ96K17.
TopDownProteomicsiQ96K17-1. [Q96K17-1]
Q96K17-2. [Q96K17-2]

Protocols and materials databases

DNASUi91408.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000313334; ENSP00000360664; ENSG00000134717. [Q96K17-1]
ENST00000472944; ENSP00000436712; ENSG00000134717. [Q96K17-2]
ENST00000489308; ENSP00000434824; ENSG00000134717. [Q96K17-3]
GeneIDi91408.
KEGGihsa:91408.
UCSCiuc001ctk.4. human. [Q96K17-1]

Organism-specific databases

CTDi91408.
GeneCardsiBTF3L4.
H-InvDBHIX0000581.
HGNCiHGNC:30547. BTF3L4.
HPAiHPA067026.
neXtProtiNX_Q96K17.
PharmGKBiPA142672545.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2240. Eukaryota.
ENOG4111JBG. LUCA.
GeneTreeiENSGT00390000006283.
HOGENOMiHOG000261245.
HOVERGENiHBG004906.
InParanoidiQ96K17.
KOiK01527.
OMAiFAITGHS.
OrthoDBiEOG7CVPXQ.
PhylomeDBiQ96K17.
TreeFamiTF317546.

Miscellaneous databases

ChiTaRSiBTF3L4. human.
GenomeRNAii91408.
PROiQ96K17.

Gene expression databases

BgeeiQ96K17.
CleanExiHS_BTF3L4.
ExpressionAtlasiQ96K17. baseline and differential.
GenevisibleiQ96K17. HS.

Family and domain databases

InterProiIPR002715. Nas_poly-pep-assoc_cplx_dom.
[Graphical view]
PfamiPF01849. NAC. 1 hit.
[Graphical view]
SMARTiSM01407. NAC. 1 hit.
[Graphical view]
PROSITEiPS51151. NAC_AB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Placenta.
  2. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
    Tissue: Lung and Prostate.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiBT3L4_HUMAN
AccessioniPrimary (citable) accession number: Q96K17
Secondary accession number(s): B3KNJ1, D3DQ32, G3V1C6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 25, 2005
Last sequence update: December 1, 2001
Last modified: July 6, 2016
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.