Q96K12 (FACR2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Fatty acyl-CoA reductase 2
EC=1.2.1.n2

Alternative name(s):
Male sterility domain-containing protein 1

Gene names

Name:	FAR2
Synonyms:	MLSTD1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	515 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Catalyzes the reduction of fatty acyl-CoA to fatty alcohols. The preferred substrates are C16, C18, C18:1 and C18:2 but low activity can be observed with C10-C14 substrates. Ref.4
Catalytic activity	Hexadecanal + CoA + NADP+ = hexadecanoyl-CoA + NADPH.
Subcellular location	Peroxisome membrane; Multi-pass membrane protein Potential. Endoplasmic reticulum membrane; Multi-pass membrane protein Potential. Note: Peroxisome in cells expressing low levels of the protein. Peroxisome and endoplasmic reticulum in cells expressing high levels of the protein.
Sequence similarities	Belongs to the fatty acyl-CoA reductase family.

Ontologies

Keywords
Biological process	Lipid biosynthesis Lipid metabolism
Cellular component	Endoplasmic reticulum Membrane Peroxisome
Coding sequence diversity	Polymorphism
Domain	Transmembrane Transmembrane helix
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	ether lipid biosynthetic process Traceable author statement. Source: Reactome long-chain fatty-acyl-CoA metabolic process Inferred from direct assay Ref.4. Source: UniProtKB
Cellular_component	endoplasmic reticulum membrane Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW peroxisomal matrix Traceable author statement. Source: Reactome peroxisomal membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	fatty-acyl-CoA reductase (alcohol-forming) activity Inferred from direct assay Ref.4. Source: UniProtKB long-chain-fatty-acyl-CoA reductase activity Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 515	515	Fatty acyl-CoA reductase 2		PRO_0000261401
Regions
	Transmembrane	465 – 484	20	Helical; Potential
	Transmembrane	491 – 510	20	Helical; Potential
Natural variations
	Natural variant	326	1	F → S. Corresponds to variant rs17400011 [ dbSNP | Ensembl ].		VAR_053801
	Natural variant	329	1	I → T. Corresponds to variant rs17404064 [ dbSNP | Ensembl ].		VAR_053802
Experimental info
	Sequence conflict	51	1	T → A in CAB66777. Ref.1
	Sequence conflict	167	1	I → T in BAA91625. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Q96K12 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: 6EFC67ED29796094	FASTA	515	59,438
	10 20 30 40 50 60 MSTIAAFYGG KSILITGATG FLGKVLMEKL FRTSPDLKVI YILVRPKAGQ TLQQRVFQIL 70 80 90 100 110 120 DSKLFEKVKE VCPNVHEKIR AIYADLNQND FAISKEDMQE LLSCTNIIFH CAATVRFDDT 130 140 150 160 170 180 LRHAVQLNVT ATRQLLLMAS QMPKLEAFIH ISTAYSNCNL KHIDEVIYPC PVEPKKIIDS 190 200 210 220 230 240 LEWLDDAIID EITPKLIRDW PNIYTYTKAL GEMVVQQESR NLNIAIIRPS IVGATWQEPF 250 260 270 280 290 300 PGWVDNINGP NGIIIATGKG FLRAIKATPM AVADVIPVDT VVNLMLAVGW YTAVHRPKST 310 320 330 340 350 360 LVYHITSGNM NPCNWHKMGV QVLATFEKIP FERPFRRPNA NFTSNSFTSQ YWNAVSHRAP 370 380 390 400 410 420 AIIYDCYLRL TGRKPRMTKL MNRLLRTVSM LEYFINRSWE WSTYNTEMLM SELSPEDQRV 430 440 450 460 470 480 FNFDVRQLNW LEYIENYVLG VKKYLLKEDM AGIPKAKQRL KRLRNIHYLF NTALFLIAWR 490 500 510 LLIARSQMAR NVWFFIVSFC YKFLSYFRAS STLKV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs." Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S., Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H., Lauber J., Duesterhoeft A., Beyer A., Koehrer K., Strack N., Mewes H.-W., Ottenwaelder B., Obermaier B. , Tampe J., Heubner D., Wambutt R., Korn B., Klein M., Poustka A. Genome Res. 11:422-435(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Placenta and Teratocarcinoma.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Placenta.
[4]	"Mammalian wax biosynthesis: I. Identification of two fatty acyl-coenzyme A reductases with different substrate specificities and tissue distributions." Cheng J.B., Russell D.W. J. Biol. Chem. 279:37789-37797(2004) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL136843 mRNA. Translation: CAB66777.1. AK001324 mRNA. Translation: BAA91625.1. AK027756 mRNA. Translation: BAB55347.1. BC022267 mRNA. Translation: AAH22267.1.
IPI	IPI00789529.
RefSeq	NP_001258712.1. NM_001271783.1. NP_060569.3. NM_018099.4.
UniGene	Hs.728955. Hs.744741.
3D structure databases
ProteinModelPortal	Q96K12.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000182377.
PTM databases
PhosphoSite	Q96K12.
Polymorphism databases
DMDM	74732166.
Proteomic databases
PaxDb	Q96K12.
PRIDE	Q96K12.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000182377; ENSP00000182377; ENSG00000064763. ENST00000536681; ENSP00000443291; ENSG00000064763.
GeneID	55711.
KEGG	hsa:55711.
UCSC	uc001ris.4. human.
Organism-specific databases
CTD	55711.
GeneCards	GC12P029302.
H-InvDB	HIX0010513.
HGNC	HGNC:25531. FAR2.
HPA	HPA015884.
neXtProt	NX_Q96K12.
PharmGKB	PA162388036.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG325153.
HOGENOM	HOG000261667.
HOVERGEN	HBG076152.
InParanoid	Q96K12.
KO	K13356.
OMA	LRNIHYL.
OrthoDB	EOG4TMR1S.
PhylomeDB	Q96K12.
Enzyme and pathway databases
Reactome	REACT_111217. Metabolism.
Gene expression databases
ArrayExpress	Q96K12.
Bgee	Q96K12.
CleanEx	HS_FAR2.
Genevestigator	Q96K12.
GermOnline	ENSG00000064763. Homo sapiens.
Family and domain databases
Gene3D	3.40.50.720. 2 hits.
InterPro	IPR026055. FAR. IPR013120. Male_sterile_NAD-bd. IPR016040. NAD(P)-bd_dom. [Graphical view]
PANTHER	PTHR11011. PTHR11011. 1 hit.
Pfam	PF07993. NAD_binding_4. 1 hit. PF03015. Sterile. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	FAR2. human.
GenomeRNAi	55711.
NextBio	60577.

Entry information

Entry name

FACR2_HUMAN

Accession

Primary (citable) accession number: Q96K12
Secondary accession number(s): Q9H0D5, Q9NVW8

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 28, 2006
Last sequence update:	December 1, 2001
Last modified:	May 29, 2013
This is version 91 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.