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Protein

Fatty acyl-CoA reductase 2

Gene

FAR2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Catalyzes the reduction of fatty acyl-CoA to fatty alcohols. The preferred substrates are C16, C18, C18:1 and C18:2 but low activity can be observed with C10-C14 substrates.1 Publication

Catalytic activityi

Hexadecanal + CoA + NADP+ = hexadecanoyl-CoA + NADPH.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Lipid biosynthesis, Lipid metabolism

Keywords - Ligandi

NADP

Enzyme and pathway databases

ReactomeiREACT_1407. Plasmalogen biosynthesis.

Names & Taxonomyi

Protein namesi
Recommended name:
Fatty acyl-CoA reductase 2 (EC:1.2.1.n2)
Alternative name(s):
Male sterility domain-containing protein 1
Gene namesi
Name:FAR2
Synonyms:MLSTD1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:25531. FAR2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei465 – 48420HelicalSequence AnalysisAdd
BLAST
Transmembranei491 – 51020HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Peroxisome

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162388036.

Polymorphism and mutation databases

DMDMi74732166.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 515515Fatty acyl-CoA reductase 2PRO_0000261401Add
BLAST

Proteomic databases

MaxQBiQ96K12.
PaxDbiQ96K12.
PRIDEiQ96K12.

PTM databases

PhosphoSiteiQ96K12.

Expressioni

Gene expression databases

BgeeiQ96K12.
CleanExiHS_FAR2.
ExpressionAtlasiQ96K12. baseline and differential.
GenevisibleiQ96K12. HS.

Organism-specific databases

HPAiHPA015884.

Interactioni

Protein-protein interaction databases

BioGridi120834. 10 interactions.
STRINGi9606.ENSP00000182377.

Structurei

3D structure databases

ProteinModelPortaliQ96K12.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the fatty acyl-CoA reductase family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG325153.
GeneTreeiENSGT00390000006367.
HOGENOMiHOG000261667.
HOVERGENiHBG076152.
InParanoidiQ96K12.
KOiK13356.
OMAiKIPFERP.
PhylomeDBiQ96K12.
TreeFamiTF313011.

Family and domain databases

Gene3Di3.40.50.720. 2 hits.
InterProiIPR026055. FAR.
IPR013120. Male_sterile_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11011. PTHR11011. 1 hit.
PfamiPF07993. NAD_binding_4. 1 hit.
PF03015. Sterile. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96K12-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSTIAAFYGG KSILITGATG FLGKVLMEKL FRTSPDLKVI YILVRPKAGQ
60 70 80 90 100
TLQQRVFQIL DSKLFEKVKE VCPNVHEKIR AIYADLNQND FAISKEDMQE
110 120 130 140 150
LLSCTNIIFH CAATVRFDDT LRHAVQLNVT ATRQLLLMAS QMPKLEAFIH
160 170 180 190 200
ISTAYSNCNL KHIDEVIYPC PVEPKKIIDS LEWLDDAIID EITPKLIRDW
210 220 230 240 250
PNIYTYTKAL GEMVVQQESR NLNIAIIRPS IVGATWQEPF PGWVDNINGP
260 270 280 290 300
NGIIIATGKG FLRAIKATPM AVADVIPVDT VVNLMLAVGW YTAVHRPKST
310 320 330 340 350
LVYHITSGNM NPCNWHKMGV QVLATFEKIP FERPFRRPNA NFTSNSFTSQ
360 370 380 390 400
YWNAVSHRAP AIIYDCYLRL TGRKPRMTKL MNRLLRTVSM LEYFINRSWE
410 420 430 440 450
WSTYNTEMLM SELSPEDQRV FNFDVRQLNW LEYIENYVLG VKKYLLKEDM
460 470 480 490 500
AGIPKAKQRL KRLRNIHYLF NTALFLIAWR LLIARSQMAR NVWFFIVSFC
510
YKFLSYFRAS STLKV
Length:515
Mass (Da):59,438
Last modified:December 1, 2001 - v1
Checksum:i6EFC67ED29796094
GO
Isoform 2 (identifier: Q96K12-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-97: Missing.

Note: No experimental confirmation available.
Show »
Length:418
Mass (Da):48,537
Checksum:iD3C00E8A95635C5F
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti51 – 511T → A in CAB66777 (PubMed:11230166).Curated
Sequence conflicti167 – 1671I → T in BAA91625 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti326 – 3261F → S.
Corresponds to variant rs17400011 [ dbSNP | Ensembl ].
VAR_053801
Natural varianti329 – 3291I → T.
Corresponds to variant rs17404064 [ dbSNP | Ensembl ].
VAR_053802

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 9797Missing in isoform 2. 1 PublicationVSP_055648Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136843 mRNA. Translation: CAB66777.1.
AK001324 mRNA. Translation: BAA91625.1.
AK027756 mRNA. Translation: BAB55347.1.
AK129857 mRNA. No translation available.
AC009318 Genomic DNA. No translation available.
AC012150 Genomic DNA. No translation available.
BC022267 mRNA. Translation: AAH22267.1.
CCDSiCCDS61084.1. [Q96K12-2]
CCDS8717.1. [Q96K12-1]
RefSeqiNP_001258712.1. NM_001271783.1. [Q96K12-1]
NP_060569.3. NM_018099.4. [Q96K12-1]
UniGeneiHs.728955.
Hs.744741.

Genome annotation databases

EnsembliENST00000182377; ENSP00000182377; ENSG00000064763. [Q96K12-1]
ENST00000536681; ENSP00000443291; ENSG00000064763. [Q96K12-1]
ENST00000547116; ENSP00000449349; ENSG00000064763. [Q96K12-2]
GeneIDi55711.
KEGGihsa:55711.
UCSCiuc001ris.5. human. [Q96K12-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136843 mRNA. Translation: CAB66777.1.
AK001324 mRNA. Translation: BAA91625.1.
AK027756 mRNA. Translation: BAB55347.1.
AK129857 mRNA. No translation available.
AC009318 Genomic DNA. No translation available.
AC012150 Genomic DNA. No translation available.
BC022267 mRNA. Translation: AAH22267.1.
CCDSiCCDS61084.1. [Q96K12-2]
CCDS8717.1. [Q96K12-1]
RefSeqiNP_001258712.1. NM_001271783.1. [Q96K12-1]
NP_060569.3. NM_018099.4. [Q96K12-1]
UniGeneiHs.728955.
Hs.744741.

3D structure databases

ProteinModelPortaliQ96K12.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120834. 10 interactions.
STRINGi9606.ENSP00000182377.

PTM databases

PhosphoSiteiQ96K12.

Polymorphism and mutation databases

DMDMi74732166.

Proteomic databases

MaxQBiQ96K12.
PaxDbiQ96K12.
PRIDEiQ96K12.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000182377; ENSP00000182377; ENSG00000064763. [Q96K12-1]
ENST00000536681; ENSP00000443291; ENSG00000064763. [Q96K12-1]
ENST00000547116; ENSP00000449349; ENSG00000064763. [Q96K12-2]
GeneIDi55711.
KEGGihsa:55711.
UCSCiuc001ris.5. human. [Q96K12-1]

Organism-specific databases

CTDi55711.
GeneCardsiGC12P029302.
H-InvDBHIX0010513.
HGNCiHGNC:25531. FAR2.
HPAiHPA015884.
MIMi616156. gene.
neXtProtiNX_Q96K12.
PharmGKBiPA162388036.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG325153.
GeneTreeiENSGT00390000006367.
HOGENOMiHOG000261667.
HOVERGENiHBG076152.
InParanoidiQ96K12.
KOiK13356.
OMAiKIPFERP.
PhylomeDBiQ96K12.
TreeFamiTF313011.

Enzyme and pathway databases

ReactomeiREACT_1407. Plasmalogen biosynthesis.

Miscellaneous databases

GenomeRNAii55711.
NextBioi35511747.
PROiQ96K12.
SOURCEiSearch...

Gene expression databases

BgeeiQ96K12.
CleanExiHS_FAR2.
ExpressionAtlasiQ96K12. baseline and differential.
GenevisibleiQ96K12. HS.

Family and domain databases

Gene3Di3.40.50.720. 2 hits.
InterProiIPR026055. FAR.
IPR013120. Male_sterile_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11011. PTHR11011. 1 hit.
PfamiPF07993. NAD_binding_4. 1 hit.
PF03015. Sterile. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Testis.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Heart, Placenta and Teratocarcinoma.
  3. "The finished DNA sequence of human chromosome 12."
    Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
    , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
    Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Placenta.
  5. "Mammalian wax biosynthesis: I. Identification of two fatty acyl-coenzyme A reductases with different substrate specificities and tissue distributions."
    Cheng J.B., Russell D.W.
    J. Biol. Chem. 279:37789-37797(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiFACR2_HUMAN
AccessioniPrimary (citable) accession number: Q96K12
Secondary accession number(s): F8VV73, Q9H0D5, Q9NVW8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: December 1, 2001
Last modified: June 24, 2015
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.