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Q96K12 (FACR2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 98. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Fatty acyl-CoA reductase 2

EC=1.2.1.n2
Alternative name(s):
Male sterility domain-containing protein 1
Gene names
Name:FAR2
Synonyms:MLSTD1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length515 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Catalyzes the reduction of fatty acyl-CoA to fatty alcohols. The preferred substrates are C16, C18, C18:1 and C18:2 but low activity can be observed with C10-C14 substrates. Ref.4

Catalytic activity

Hexadecanal + CoA + NADP+ = hexadecanoyl-CoA + NADPH.

Subcellular location

Peroxisome membrane; Multi-pass membrane protein Potential. Endoplasmic reticulum membrane; Multi-pass membrane protein Potential. Note: Peroxisome in cells expressing low levels of the protein. Peroxisome and endoplasmic reticulum in cells expressing high levels of the protein.

Sequence similarities

Belongs to the fatty acyl-CoA reductase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 515515Fatty acyl-CoA reductase 2
PRO_0000261401

Regions

Transmembrane465 – 48420Helical; Potential
Transmembrane491 – 51020Helical; Potential

Natural variations

Natural variant3261F → S.
Corresponds to variant rs17400011 [ dbSNP | Ensembl ].
VAR_053801
Natural variant3291I → T.
Corresponds to variant rs17404064 [ dbSNP | Ensembl ].
VAR_053802

Experimental info

Sequence conflict511T → A in CAB66777. Ref.1
Sequence conflict1671I → T in BAA91625. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q96K12 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: 6EFC67ED29796094

FASTA51559,438
        10         20         30         40         50         60 
MSTIAAFYGG KSILITGATG FLGKVLMEKL FRTSPDLKVI YILVRPKAGQ TLQQRVFQIL 

        70         80         90        100        110        120 
DSKLFEKVKE VCPNVHEKIR AIYADLNQND FAISKEDMQE LLSCTNIIFH CAATVRFDDT 

       130        140        150        160        170        180 
LRHAVQLNVT ATRQLLLMAS QMPKLEAFIH ISTAYSNCNL KHIDEVIYPC PVEPKKIIDS 

       190        200        210        220        230        240 
LEWLDDAIID EITPKLIRDW PNIYTYTKAL GEMVVQQESR NLNIAIIRPS IVGATWQEPF 

       250        260        270        280        290        300 
PGWVDNINGP NGIIIATGKG FLRAIKATPM AVADVIPVDT VVNLMLAVGW YTAVHRPKST 

       310        320        330        340        350        360 
LVYHITSGNM NPCNWHKMGV QVLATFEKIP FERPFRRPNA NFTSNSFTSQ YWNAVSHRAP 

       370        380        390        400        410        420 
AIIYDCYLRL TGRKPRMTKL MNRLLRTVSM LEYFINRSWE WSTYNTEMLM SELSPEDQRV 

       430        440        450        460        470        480 
FNFDVRQLNW LEYIENYVLG VKKYLLKEDM AGIPKAKQRL KRLRNIHYLF NTALFLIAWR 

       490        500        510 
LLIARSQMAR NVWFFIVSFC YKFLSYFRAS STLKV 

« Hide

References

« Hide 'large scale' references
[1]"Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs."
Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S., Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H., Lauber J., Duesterhoeft A., Beyer A., Koehrer K., Strack N., Mewes H.-W., Ottenwaelder B., Obermaier B. expand/collapse author list , Tampe J., Heubner D., Wambutt R., Korn B., Klein M., Poustka A.
Genome Res. 11:422-435(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Testis.
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Placenta and Teratocarcinoma.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Placenta.
[4]"Mammalian wax biosynthesis: I. Identification of two fatty acyl-coenzyme A reductases with different substrate specificities and tissue distributions."
Cheng J.B., Russell D.W.
J. Biol. Chem. 279:37789-37797(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL136843 mRNA. Translation: CAB66777.1.
AK001324 mRNA. Translation: BAA91625.1.
AK027756 mRNA. Translation: BAB55347.1.
BC022267 mRNA. Translation: AAH22267.1.
RefSeqNP_001258712.1. NM_001271783.1.
NP_060569.3. NM_018099.4.
UniGeneHs.728955.
Hs.744741.

3D structure databases

ProteinModelPortalQ96K12.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid120834. 2 interactions.
STRING9606.ENSP00000182377.

PTM databases

PhosphoSiteQ96K12.

Polymorphism databases

DMDM74732166.

Proteomic databases

PaxDbQ96K12.
PRIDEQ96K12.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000182377; ENSP00000182377; ENSG00000064763.
ENST00000536681; ENSP00000443291; ENSG00000064763.
GeneID55711.
KEGGhsa:55711.
UCSCuc001ris.5. human.

Organism-specific databases

CTD55711.
GeneCardsGC12P029302.
H-InvDBHIX0010513.
HGNCHGNC:25531. FAR2.
HPAHPA015884.
neXtProtNX_Q96K12.
PharmGKBPA162388036.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG325153.
HOGENOMHOG000261667.
HOVERGENHBG076152.
InParanoidQ96K12.
KOK13356.
OMALRNIHYL.
PhylomeDBQ96K12.
TreeFamTF313011.

Enzyme and pathway databases

ReactomeREACT_111217. Metabolism.

Gene expression databases

ArrayExpressQ96K12.
BgeeQ96K12.
CleanExHS_FAR2.
GenevestigatorQ96K12.

Family and domain databases

Gene3D3.40.50.720. 2 hits.
InterProIPR026055. FAR.
IPR013120. Male_sterile_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERPTHR11011. PTHR11011. 1 hit.
PfamPF07993. NAD_binding_4. 1 hit.
PF03015. Sterile. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSFAR2. human.
GenomeRNAi55711.
NextBio60577.
PROQ96K12.

Entry information

Entry nameFACR2_HUMAN
AccessionPrimary (citable) accession number: Q96K12
Secondary accession number(s): Q9H0D5, Q9NVW8
Entry history
Integrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: December 1, 2001
Last modified: April 16, 2014
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 12

Human chromosome 12: entries, gene names and cross-references to MIM