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Protein

Solute carrier family 41 member 2

Gene

SLC41A2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Acts as a plasma-membrane magnesium transporter.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ion transport, Transport

Keywords - Ligandi

Magnesium

Enzyme and pathway databases

ReactomeiR-HSA-425410. Metal ion SLC transporters.

Protein family/group databases

TCDBi1.A.26.2.2. the mg(2+) transporter-e (mgte) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 41 member 2
Gene namesi
Name:SLC41A2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:31045. SLC41A2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 162162Extracellular1 PublicationAdd
BLAST
Transmembranei163 – 18321HelicalSequence analysisAdd
BLAST
Topological domaini184 – 19512Cytoplasmic1 PublicationAdd
BLAST
Transmembranei196 – 21621HelicalSequence analysisAdd
BLAST
Topological domaini217 – 24529Extracellular1 PublicationAdd
BLAST
Transmembranei246 – 26621HelicalSequence analysisAdd
BLAST
Topological domaini267 – 28216Cytoplasmic1 PublicationAdd
BLAST
Transmembranei283 – 30321HelicalSequence analysisAdd
BLAST
Topological domaini304 – 31310Extracellular1 Publication
Transmembranei314 – 33421HelicalSequence analysisAdd
BLAST
Topological domaini335 – 34713Cytoplasmic1 PublicationAdd
BLAST
Transmembranei348 – 36821HelicalSequence analysisAdd
BLAST
Topological domaini369 – 3768Extracellular1 Publication
Transmembranei377 – 39721HelicalSequence analysisAdd
BLAST
Topological domaini398 – 4069Cytoplasmic1 Publication
Transmembranei407 – 42721HelicalSequence analysisAdd
BLAST
Topological domaini428 – 46942Extracellular1 PublicationAdd
BLAST
Transmembranei470 – 49021HelicalSequence analysisAdd
BLAST
Topological domaini491 – 4988Cytoplasmic1 Publication
Transmembranei499 – 51921HelicalSequence analysisAdd
BLAST
Topological domaini520 – 54324Extracellular1 PublicationAdd
BLAST
Transmembranei544 – 56421HelicalSequence analysisAdd
BLAST
Topological domaini565 – 5739Cytoplasmic1 Publication

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134931432.

Polymorphism and mutation databases

BioMutaiSLC41A2.
DMDMi152112286.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 573573Solute carrier family 41 member 2PRO_0000295040Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei136 – 1361PhosphoserineBy similarity
Modified residuei137 – 1371PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ96JW4.
MaxQBiQ96JW4.
PaxDbiQ96JW4.
PeptideAtlasiQ96JW4.
PRIDEiQ96JW4.

PTM databases

iPTMnetiQ96JW4.
PhosphoSiteiQ96JW4.

Expressioni

Gene expression databases

BgeeiENSG00000136052.
CleanExiHS_SLC41A2.
ExpressionAtlasiQ96JW4. baseline and differential.
GenevisibleiQ96JW4. HS.

Organism-specific databases

HPAiHPA038658.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CCDC155Q8N6L03EBI-10290130,EBI-749265

Protein-protein interaction databases

BioGridi123891. 2 interactions.
IntActiQ96JW4. 1 interaction.
MINTiMINT-4722037.
STRINGi9606.ENSP00000258538.

Structurei

3D structure databases

ProteinModelPortaliQ96JW4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SLC41A transporter family.Curated

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3788. Eukaryota.
ENOG410XSTG. LUCA.
GeneTreeiENSGT00390000016816.
HOGENOMiHOG000007017.
HOVERGENiHBG057187.
InParanoidiQ96JW4.
KOiK15122.
OMAiYCDGREA.
OrthoDBiEOG091G08MB.
PhylomeDBiQ96JW4.
TreeFamiTF313647.

Family and domain databases

Gene3Di1.10.357.20. 2 hits.
InterProiIPR006667. SLC41_membr_dom.
[Graphical view]
PfamiPF01769. MgtE. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96JW4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTNSKGRSIT DKTSGGPSSG GGFVDWTLRL NTIQSDKFLN LLLSMVPVIY
60 70 80 90 100
QKNQEDRHKK ANGIWQDGLS TAVQTFSNRS EQHMEYHSFS EQSFHANNGH
110 120 130 140 150
ASSSCSQKYD DYANYNYCDG RETSETTAML QDEDISSDGD EDAIVEVTPK
160 170 180 190 200
LPKESSGIMA LQILVPFLLA GFGTVSAGMV LDIVQHWEVF RKVTEVFILV
210 220 230 240 250
PALLGLKGNL EMTLASRLST AVNIGKMDSP IEKWNLIIGN LALKQVQATV
260 270 280 290 300
VGFLAAVAAI ILGWIPEGKY YLDHSILLCS SSVATAFIAS LLQGIIMVGV
310 320 330 340 350
IVGSKKTGIN PDNVATPIAA SFGDLITLAI LAWISQGLYS CLETYYYISP
360 370 380 390 400
LVGVFFLALT PIWIIIAAKH PATRTVLHSG WEPVITAMVI SSIGGLILDT
410 420 430 440 450
TVSDPNLVGI VVYTPVINGI GGNLVAIQAS RISTYLHLHS IPGELPDEPK
460 470 480 490 500
GCYYPFRTFF GPGVNNKSAQ VLLLLVIPGH LIFLYTIHLM KSGHTSLTII
510 520 530 540 550
FIVVYLFGAV LQVFTLLWIA DWMVHHFWRK GKDPDSFSIP YLTALGDLLG
560 570
TALLALSFHF LWLIGDRDGD VGD
Length:573
Mass (Da):62,473
Last modified:July 10, 2007 - v2
Checksum:i1BD0FF32AF91DA02
GO

Sequence cautioni

The sequence AAH36734 differs from that shown. Reason: Erroneous initiation. Curated
The sequence AAI06872 differs from that shown. Reason: Erroneous initiation. Curated
The sequence AAI06873 differs from that shown. Reason: Erroneous initiation. Curated
The sequence BAB55402 differs from that shown. Reason: Frameshift at positions 69, 101 and 103. Curated
The sequence CAB66762 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti115 – 1151Y → C in BAB55402 (PubMed:14702039).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK027838 mRNA. Translation: BAB55402.1. Frameshift.
BC036734 mRNA. Translation: AAH36734.1. Different initiation.
BC106871 mRNA. Translation: AAI06872.2. Different initiation.
BC106872 mRNA. Translation: AAI06873.2. Different initiation.
AL136828 mRNA. Translation: CAB66762.1. Different initiation.
CCDSiCCDS9100.2.
RefSeqiNP_115524.3. NM_032148.3.
XP_005269233.1. XM_005269176.1.
XP_005269235.1. XM_005269178.1.
XP_005269236.1. XM_005269179.1.
XP_006719693.1. XM_006719630.2.
XP_011537109.1. XM_011538807.2.
XP_011537110.1. XM_011538808.1.
XP_011537111.1. XM_011538809.1.
XP_011537112.1. XM_011538810.2.
XP_011537113.1. XM_011538811.2.
UniGeneiHs.577463.

Genome annotation databases

EnsembliENST00000258538; ENSP00000258538; ENSG00000136052.
GeneIDi84102.
KEGGihsa:84102.
UCSCiuc001tla.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK027838 mRNA. Translation: BAB55402.1. Frameshift.
BC036734 mRNA. Translation: AAH36734.1. Different initiation.
BC106871 mRNA. Translation: AAI06872.2. Different initiation.
BC106872 mRNA. Translation: AAI06873.2. Different initiation.
AL136828 mRNA. Translation: CAB66762.1. Different initiation.
CCDSiCCDS9100.2.
RefSeqiNP_115524.3. NM_032148.3.
XP_005269233.1. XM_005269176.1.
XP_005269235.1. XM_005269178.1.
XP_005269236.1. XM_005269179.1.
XP_006719693.1. XM_006719630.2.
XP_011537109.1. XM_011538807.2.
XP_011537110.1. XM_011538808.1.
XP_011537111.1. XM_011538809.1.
XP_011537112.1. XM_011538810.2.
XP_011537113.1. XM_011538811.2.
UniGeneiHs.577463.

3D structure databases

ProteinModelPortaliQ96JW4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123891. 2 interactions.
IntActiQ96JW4. 1 interaction.
MINTiMINT-4722037.
STRINGi9606.ENSP00000258538.

Protein family/group databases

TCDBi1.A.26.2.2. the mg(2+) transporter-e (mgte) family.

PTM databases

iPTMnetiQ96JW4.
PhosphoSiteiQ96JW4.

Polymorphism and mutation databases

BioMutaiSLC41A2.
DMDMi152112286.

Proteomic databases

EPDiQ96JW4.
MaxQBiQ96JW4.
PaxDbiQ96JW4.
PeptideAtlasiQ96JW4.
PRIDEiQ96JW4.

Protocols and materials databases

DNASUi84102.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000258538; ENSP00000258538; ENSG00000136052.
GeneIDi84102.
KEGGihsa:84102.
UCSCiuc001tla.4. human.

Organism-specific databases

CTDi84102.
GeneCardsiSLC41A2.
HGNCiHGNC:31045. SLC41A2.
HPAiHPA038658.
MIMi610802. gene.
neXtProtiNX_Q96JW4.
PharmGKBiPA134931432.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3788. Eukaryota.
ENOG410XSTG. LUCA.
GeneTreeiENSGT00390000016816.
HOGENOMiHOG000007017.
HOVERGENiHBG057187.
InParanoidiQ96JW4.
KOiK15122.
OMAiYCDGREA.
OrthoDBiEOG091G08MB.
PhylomeDBiQ96JW4.
TreeFamiTF313647.

Enzyme and pathway databases

ReactomeiR-HSA-425410. Metal ion SLC transporters.

Miscellaneous databases

ChiTaRSiSLC41A2. human.
GenomeRNAii84102.
PROiQ96JW4.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000136052.
CleanExiHS_SLC41A2.
ExpressionAtlasiQ96JW4. baseline and differential.
GenevisibleiQ96JW4. HS.

Family and domain databases

Gene3Di1.10.357.20. 2 hits.
InterProiIPR006667. SLC41_membr_dom.
[Graphical view]
PfamiPF01769. MgtE. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiS41A2_HUMAN
AccessioniPrimary (citable) accession number: Q96JW4
Secondary accession number(s): Q3KP68, Q9H0E5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: July 10, 2007
Last modified: September 7, 2016
This is version 115 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.