Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Solute carrier family 41 member 2

Gene

SLC41A2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Acts as a plasma-membrane magnesium transporter.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ion transport, Transport

Keywords - Ligandi

Magnesium

Enzyme and pathway databases

BioCyciZFISH:ENSG00000136052-MONOMER.
ReactomeiR-HSA-425410. Metal ion SLC transporters.

Protein family/group databases

TCDBi1.A.26.2.2. the mg(2+) transporter-e (mgte) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 41 member 2
Gene namesi
Name:SLC41A2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:31045. SLC41A2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 162Extracellular1 PublicationAdd BLAST162
Transmembranei163 – 183HelicalSequence analysisAdd BLAST21
Topological domaini184 – 195Cytoplasmic1 PublicationAdd BLAST12
Transmembranei196 – 216HelicalSequence analysisAdd BLAST21
Topological domaini217 – 245Extracellular1 PublicationAdd BLAST29
Transmembranei246 – 266HelicalSequence analysisAdd BLAST21
Topological domaini267 – 282Cytoplasmic1 PublicationAdd BLAST16
Transmembranei283 – 303HelicalSequence analysisAdd BLAST21
Topological domaini304 – 313Extracellular1 Publication10
Transmembranei314 – 334HelicalSequence analysisAdd BLAST21
Topological domaini335 – 347Cytoplasmic1 PublicationAdd BLAST13
Transmembranei348 – 368HelicalSequence analysisAdd BLAST21
Topological domaini369 – 376Extracellular1 Publication8
Transmembranei377 – 397HelicalSequence analysisAdd BLAST21
Topological domaini398 – 406Cytoplasmic1 Publication9
Transmembranei407 – 427HelicalSequence analysisAdd BLAST21
Topological domaini428 – 469Extracellular1 PublicationAdd BLAST42
Transmembranei470 – 490HelicalSequence analysisAdd BLAST21
Topological domaini491 – 498Cytoplasmic1 Publication8
Transmembranei499 – 519HelicalSequence analysisAdd BLAST21
Topological domaini520 – 543Extracellular1 PublicationAdd BLAST24
Transmembranei544 – 564HelicalSequence analysisAdd BLAST21
Topological domaini565 – 573Cytoplasmic1 Publication9

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi84102.
OpenTargetsiENSG00000136052.
PharmGKBiPA134931432.

Polymorphism and mutation databases

BioMutaiSLC41A2.
DMDMi152112286.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002950401 – 573Solute carrier family 41 member 2Add BLAST573

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei136PhosphoserineBy similarity1
Modified residuei137PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ96JW4.
MaxQBiQ96JW4.
PaxDbiQ96JW4.
PeptideAtlasiQ96JW4.
PRIDEiQ96JW4.

PTM databases

iPTMnetiQ96JW4.
PhosphoSitePlusiQ96JW4.

Expressioni

Gene expression databases

BgeeiENSG00000136052.
CleanExiHS_SLC41A2.
ExpressionAtlasiQ96JW4. baseline and differential.
GenevisibleiQ96JW4. HS.

Organism-specific databases

HPAiHPA038658.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CCDC155Q8N6L05EBI-10290130,EBI-749265

Protein-protein interaction databases

BioGridi123891. 2 interactors.
IntActiQ96JW4. 4 interactors.
MINTiMINT-4722037.
STRINGi9606.ENSP00000258538.

Structurei

3D structure databases

ProteinModelPortaliQ96JW4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SLC41A transporter family.Curated

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3788. Eukaryota.
ENOG410XSTG. LUCA.
GeneTreeiENSGT00390000016816.
HOGENOMiHOG000007017.
HOVERGENiHBG057187.
InParanoidiQ96JW4.
KOiK15122.
OMAiYCDGREA.
OrthoDBiEOG091G08MB.
PhylomeDBiQ96JW4.
TreeFamiTF313647.

Family and domain databases

Gene3Di1.10.357.20. 2 hits.
InterProiIPR006667. SLC41_membr_dom.
[Graphical view]
PfamiPF01769. MgtE. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96JW4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTNSKGRSIT DKTSGGPSSG GGFVDWTLRL NTIQSDKFLN LLLSMVPVIY
60 70 80 90 100
QKNQEDRHKK ANGIWQDGLS TAVQTFSNRS EQHMEYHSFS EQSFHANNGH
110 120 130 140 150
ASSSCSQKYD DYANYNYCDG RETSETTAML QDEDISSDGD EDAIVEVTPK
160 170 180 190 200
LPKESSGIMA LQILVPFLLA GFGTVSAGMV LDIVQHWEVF RKVTEVFILV
210 220 230 240 250
PALLGLKGNL EMTLASRLST AVNIGKMDSP IEKWNLIIGN LALKQVQATV
260 270 280 290 300
VGFLAAVAAI ILGWIPEGKY YLDHSILLCS SSVATAFIAS LLQGIIMVGV
310 320 330 340 350
IVGSKKTGIN PDNVATPIAA SFGDLITLAI LAWISQGLYS CLETYYYISP
360 370 380 390 400
LVGVFFLALT PIWIIIAAKH PATRTVLHSG WEPVITAMVI SSIGGLILDT
410 420 430 440 450
TVSDPNLVGI VVYTPVINGI GGNLVAIQAS RISTYLHLHS IPGELPDEPK
460 470 480 490 500
GCYYPFRTFF GPGVNNKSAQ VLLLLVIPGH LIFLYTIHLM KSGHTSLTII
510 520 530 540 550
FIVVYLFGAV LQVFTLLWIA DWMVHHFWRK GKDPDSFSIP YLTALGDLLG
560 570
TALLALSFHF LWLIGDRDGD VGD
Length:573
Mass (Da):62,473
Last modified:July 10, 2007 - v2
Checksum:i1BD0FF32AF91DA02
GO

Sequence cautioni

The sequence AAH36734 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAI06872 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAI06873 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB55402 differs from that shown. Reason: Frameshift at positions 69, 101 and 103.Curated
The sequence CAB66762 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti115Y → C in BAB55402 (PubMed:14702039).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK027838 mRNA. Translation: BAB55402.1. Frameshift.
BC036734 mRNA. Translation: AAH36734.1. Different initiation.
BC106871 mRNA. Translation: AAI06872.2. Different initiation.
BC106872 mRNA. Translation: AAI06873.2. Different initiation.
AL136828 mRNA. Translation: CAB66762.1. Different initiation.
CCDSiCCDS9100.2.
RefSeqiNP_115524.3. NM_032148.3.
XP_005269233.1. XM_005269176.1.
XP_005269235.1. XM_005269178.1.
XP_005269236.1. XM_005269179.1.
XP_006719693.1. XM_006719630.2.
XP_011537109.1. XM_011538807.2.
XP_011537110.1. XM_011538808.1.
XP_011537111.1. XM_011538809.1.
XP_011537112.1. XM_011538810.2.
XP_011537113.1. XM_011538811.2.
XP_016875502.1. XM_017020013.1.
UniGeneiHs.577463.

Genome annotation databases

EnsembliENST00000258538; ENSP00000258538; ENSG00000136052.
GeneIDi84102.
KEGGihsa:84102.
UCSCiuc001tla.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK027838 mRNA. Translation: BAB55402.1. Frameshift.
BC036734 mRNA. Translation: AAH36734.1. Different initiation.
BC106871 mRNA. Translation: AAI06872.2. Different initiation.
BC106872 mRNA. Translation: AAI06873.2. Different initiation.
AL136828 mRNA. Translation: CAB66762.1. Different initiation.
CCDSiCCDS9100.2.
RefSeqiNP_115524.3. NM_032148.3.
XP_005269233.1. XM_005269176.1.
XP_005269235.1. XM_005269178.1.
XP_005269236.1. XM_005269179.1.
XP_006719693.1. XM_006719630.2.
XP_011537109.1. XM_011538807.2.
XP_011537110.1. XM_011538808.1.
XP_011537111.1. XM_011538809.1.
XP_011537112.1. XM_011538810.2.
XP_011537113.1. XM_011538811.2.
XP_016875502.1. XM_017020013.1.
UniGeneiHs.577463.

3D structure databases

ProteinModelPortaliQ96JW4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123891. 2 interactors.
IntActiQ96JW4. 4 interactors.
MINTiMINT-4722037.
STRINGi9606.ENSP00000258538.

Protein family/group databases

TCDBi1.A.26.2.2. the mg(2+) transporter-e (mgte) family.

PTM databases

iPTMnetiQ96JW4.
PhosphoSitePlusiQ96JW4.

Polymorphism and mutation databases

BioMutaiSLC41A2.
DMDMi152112286.

Proteomic databases

EPDiQ96JW4.
MaxQBiQ96JW4.
PaxDbiQ96JW4.
PeptideAtlasiQ96JW4.
PRIDEiQ96JW4.

Protocols and materials databases

DNASUi84102.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000258538; ENSP00000258538; ENSG00000136052.
GeneIDi84102.
KEGGihsa:84102.
UCSCiuc001tla.4. human.

Organism-specific databases

CTDi84102.
DisGeNETi84102.
GeneCardsiSLC41A2.
HGNCiHGNC:31045. SLC41A2.
HPAiHPA038658.
MIMi610802. gene.
neXtProtiNX_Q96JW4.
OpenTargetsiENSG00000136052.
PharmGKBiPA134931432.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3788. Eukaryota.
ENOG410XSTG. LUCA.
GeneTreeiENSGT00390000016816.
HOGENOMiHOG000007017.
HOVERGENiHBG057187.
InParanoidiQ96JW4.
KOiK15122.
OMAiYCDGREA.
OrthoDBiEOG091G08MB.
PhylomeDBiQ96JW4.
TreeFamiTF313647.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000136052-MONOMER.
ReactomeiR-HSA-425410. Metal ion SLC transporters.

Miscellaneous databases

ChiTaRSiSLC41A2. human.
GenomeRNAii84102.
PROiQ96JW4.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000136052.
CleanExiHS_SLC41A2.
ExpressionAtlasiQ96JW4. baseline and differential.
GenevisibleiQ96JW4. HS.

Family and domain databases

Gene3Di1.10.357.20. 2 hits.
InterProiIPR006667. SLC41_membr_dom.
[Graphical view]
PfamiPF01769. MgtE. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiS41A2_HUMAN
AccessioniPrimary (citable) accession number: Q96JW4
Secondary accession number(s): Q3KP68, Q9H0E5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: July 10, 2007
Last modified: November 30, 2016
This is version 118 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.