ID   S45A3_HUMAN             Reviewed;         553 AA.
AC   Q96JT2; A8K2U9;
DT   13-APR-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   24-JAN-2024, entry version 144.
DE   RecName: Full=Solute carrier family 45 member 3;
DE   AltName: Full=Prostate cancer-associated protein 6;
DE   AltName: Full=Prostein;
GN   Name=SLC45A3 {ECO:0000312|HGNC:HGNC:8642}; Synonyms=PCANAP6, PRST;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND INDUCTION.
RC   TISSUE=Prostate;
RX   PubMed=11245466;
RA   Xu J., Kalos M., Stolk J.A., Zasloff E.J., Zhang X., Houghton R.L.,
RA   Filho A.M., Nolasco M., Badaro R., Reed S.G.;
RT   "Identification and characterization of prostein, a novel prostate-specific
RT   protein.";
RL   Cancer Res. 61:1563-1568(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Thalamus, and Tongue;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=PNS;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [5]
RP   TISSUE SPECIFICITY.
RX   PubMed=14997204; DOI=10.1038/sj.bjc.6601642;
RA   Kiessling A., Stevanovic S., Fuessel S., Weigle B., Rieger M.A., Temme A.,
RA   Rieber E.P., Schmitz M.;
RT   "Identification of an HLA-A(*)0201-restricted T-cell epitope derived from
RT   the prostate cancer-associated protein prostein.";
RL   Br. J. Cancer 90:1034-1040(2004).
CC   -!- FUNCTION: Proton-associated sucrose transporter. May be able to
CC       transport also glucose and fructose. {ECO:0000250|UniProtKB:Q8K0H7}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H(+)(out) + sucrose(out) = H(+)(in) + sucrose(in);
CC         Xref=Rhea:RHEA:72187, ChEBI:CHEBI:15378, ChEBI:CHEBI:17992;
CC         Evidence={ECO:0000250|UniProtKB:Q8K0H7};
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Prostate specific. Expressed in all prostatic
CC       glandular cells. Expressed both in normal and cancerous prostates.
CC       {ECO:0000269|PubMed:11245466, ECO:0000269|PubMed:14997204}.
CC   -!- INDUCTION: Up-regulated by androgens. {ECO:0000269|PubMed:11245466}.
CC   -!- MISCELLANEOUS: Marker for prostate cells. May be used, in case of
CC       prostate cancers, as a target antigen for prostate carcinomas-directed
CC       cytotoxic T-cell lymphocytes.
CC   -!- SIMILARITY: Belongs to the glycoside-pentoside-hexuronide (GPH) cation
CC       symporter transporter (TC 2.A.2) family. {ECO:0000305}.
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DR   EMBL; AY033593; AAK54386.1; -; mRNA.
DR   EMBL; AK290364; BAF83053.1; -; mRNA.
DR   EMBL; AK313479; BAG36263.1; -; mRNA.
DR   EMBL; CH471067; EAW91575.1; -; Genomic_DNA.
DR   EMBL; BC050416; AAH50416.1; -; mRNA.
DR   CCDS; CCDS1458.1; -.
DR   RefSeq; NP_149093.1; NM_033102.2.
DR   RefSeq; XP_005245613.1; XM_005245556.3.
DR   RefSeq; XP_005245614.1; XM_005245557.4.
DR   RefSeq; XP_016858127.1; XM_017002638.1.
DR   AlphaFoldDB; Q96JT2; -.
DR   SMR; Q96JT2; -.
DR   BioGRID; 124520; 8.
DR   STRING; 9606.ENSP00000356113; -.
DR   TCDB; 2.A.2.4.8; the glycoside-pentoside-hexuronide (gph):cation symporter family.
DR   iPTMnet; Q96JT2; -.
DR   PhosphoSitePlus; Q96JT2; -.
DR   SwissPalm; Q96JT2; -.
DR   BioMuta; SLC45A3; -.
DR   DMDM; 46396996; -.
DR   MassIVE; Q96JT2; -.
DR   MaxQB; Q96JT2; -.
DR   PaxDb; 9606-ENSP00000356113; -.
DR   PeptideAtlas; Q96JT2; -.
DR   ProteomicsDB; 77008; -.
DR   Antibodypedia; 20683; 262 antibodies from 30 providers.
DR   DNASU; 85414; -.
DR   Ensembl; ENST00000367145.4; ENSP00000356113.3; ENSG00000158715.6.
DR   GeneID; 85414; -.
DR   KEGG; hsa:85414; -.
DR   MANE-Select; ENST00000367145.4; ENSP00000356113.3; NM_033102.3; NP_149093.1.
DR   UCSC; uc001hda.2; human.
DR   AGR; HGNC:8642; -.
DR   CTD; 85414; -.
DR   DisGeNET; 85414; -.
DR   GeneCards; SLC45A3; -.
DR   HGNC; HGNC:8642; SLC45A3.
DR   HPA; ENSG00000158715; Tissue enriched (prostate).
DR   MIM; 605097; gene.
DR   neXtProt; NX_Q96JT2; -.
DR   OpenTargets; ENSG00000158715; -.
DR   PharmGKB; PA32981; -.
DR   VEuPathDB; HostDB:ENSG00000158715; -.
DR   eggNOG; KOG0637; Eukaryota.
DR   GeneTree; ENSGT00950000182914; -.
DR   HOGENOM; CLU_015081_2_2_1; -.
DR   InParanoid; Q96JT2; -.
DR   OMA; FQWYALF; -.
DR   OrthoDB; 5480802at2759; -.
DR   PhylomeDB; Q96JT2; -.
DR   TreeFam; TF325412; -.
DR   PathwayCommons; Q96JT2; -.
DR   Reactome; R-HSA-189200; Cellular hexose transport.
DR   BioGRID-ORCS; 85414; 15 hits in 1159 CRISPR screens.
DR   ChiTaRS; SLC45A3; human.
DR   GeneWiki; SLC45A3; -.
DR   GenomeRNAi; 85414; -.
DR   Pharos; Q96JT2; Tbio.
DR   PRO; PR:Q96JT2; -.
DR   Proteomes; UP000005640; Chromosome 1.
DR   RNAct; Q96JT2; Protein.
DR   Bgee; ENSG00000158715; Expressed in prostate gland and 142 other cell types or tissues.
DR   GO; GO:0016020; C:membrane; IBA:GO_Central.
DR   GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR   GO; GO:0008506; F:sucrose:proton symporter activity; ISS:ParkinsonsUK-UCL.
DR   GO; GO:0051119; F:sugar transmembrane transporter activity; TAS:Reactome.
DR   GO; GO:0008645; P:hexose transmembrane transport; TAS:Reactome.
DR   GO; GO:0045723; P:positive regulation of fatty acid biosynthetic process; ISS:ParkinsonsUK-UCL.
DR   GO; GO:0010907; P:positive regulation of glucose metabolic process; ISS:ParkinsonsUK-UCL.
DR   GO; GO:0048713; P:regulation of oligodendrocyte differentiation; ISS:ParkinsonsUK-UCL.
DR   GO; GO:0015770; P:sucrose transport; ISS:ParkinsonsUK-UCL.
DR   CDD; cd17313; MFS_SLC45_SUC; 1.
DR   Gene3D; 1.20.1250.20; MFS general substrate transporter like domains; 2.
DR   InterPro; IPR011701; MFS.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   PANTHER; PTHR19432:SF37; SOLUTE CARRIER FAMILY 45 MEMBER 3; 1.
DR   PANTHER; PTHR19432; SUGAR TRANSPORTER; 1.
DR   Pfam; PF07690; MFS_1; 1.
DR   SUPFAM; SSF103473; MFS general substrate transporter; 1.
DR   Genevisible; Q96JT2; HS.
PE   2: Evidence at transcript level;
KW   Membrane; Reference proteome; Symport; Transmembrane; Transmembrane helix;
KW   Transport.
FT   CHAIN           1..553
FT                   /note="Solute carrier family 45 member 3"
FT                   /id="PRO_0000122519"
FT   TRANSMEM        19..39
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        52..72
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        88..108
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        120..140
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        161..181
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        198..218
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        275..295
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        323..343
FT                   /note="Helical; Name=8"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        353..373
FT                   /note="Helical; Name=9"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        382..402
FT                   /note="Helical; Name=10"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        522..542
FT                   /note="Helical; Name=11"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   553 AA;  59323 MW;  0AFA23FBC742A667 CRC64;
     MVQRLWVSRL LRHRKAQLLL VNLLTFGLEV CLAAGITYVP PLLLEVGVEE KFMTMVLGIG
     PVLGLVCVPL LGSASDHWRG RYGRRRPFIW ALSLGILLSL FLIPRAGWLA GLLCPDPRPL
     ELALLILGVG LLDFCGQVCF TPLEALLSDL FRDPDHCRQA YSVYAFMISL GGCLGYLLPA
     IDWDTSALAP YLGTQEECLF GLLTLIFLTC VAATLLVAEE AALGPTEPAE GLSAPSLSPH
     CCPCRARLAF RNLGALLPRL HQLCCRMPRT LRRLFVAELC SWMALMTFTL FYTDFVGEGL
     YQGVPRAEPG TEARRHYDEG VRMGSLGLFL QCAISLVFSL VMDRLVQRFG TRAVYLASVA
     AFPVAAGATC LSHSVAVVTA SAALTGFTFS ALQILPYTLA SLYHREKQVF LPKYRGDTGG
     ASSEDSLMTS FLPGPKPGAP FPNGHVGAGG SGLLPPPPAL CGASACDVSV RVVVGEPTEA
     RVVPGRGICL DLAILDSAFL LSQVAPSLFM GSIVQLSQSV TAYMVSAAGL GLVAIYFATQ
     VVFDKSDLAK YSA
//