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Q96JT2

- S45A3_HUMAN

UniProt

Q96JT2 - S45A3_HUMAN

Protein

Solute carrier family 45 member 3

Gene

SLC45A3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 92 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    GO - Biological processi

    1. transmembrane transport Source: InterPro

    Keywords - Biological processi

    Transport

    Protein family/group databases

    TCDBi2.A.2.4.8. the glycoside-pentoside-hexuronide (gph):cation symporter family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Solute carrier family 45 member 3
    Alternative name(s):
    Prostate cancer-associated protein 6
    Prostein
    Gene namesi
    Name:SLC45A3
    Synonyms:PCANAP6, PRST
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:8642. SLC45A3.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA32981.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 553553Solute carrier family 45 member 3PRO_0000122519Add
    BLAST

    Proteomic databases

    MaxQBiQ96JT2.
    PaxDbiQ96JT2.
    PRIDEiQ96JT2.

    PTM databases

    PhosphoSiteiQ96JT2.

    Expressioni

    Tissue specificityi

    Prostate specific. Expressed in all prostatic glandular cells. Expressed both in normal and cancerous prostates.2 Publications

    Inductioni

    Up-regulated by androgens.1 Publication

    Gene expression databases

    ArrayExpressiQ96JT2.
    BgeeiQ96JT2.
    CleanExiHS_SLC45A3.
    GenevestigatoriQ96JT2.

    Organism-specific databases

    HPAiHPA019073.
    HPA019075.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000356113.

    Structurei

    3D structure databases

    ProteinModelPortaliQ96JT2.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei19 – 3921Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei52 – 7221Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei88 – 10821Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei120 – 14021Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei161 – 18121Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei198 – 21821Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei275 – 29521Helical; Name=7Sequence AnalysisAdd
    BLAST
    Transmembranei323 – 34321Helical; Name=8Sequence AnalysisAdd
    BLAST
    Transmembranei353 – 37321Helical; Name=9Sequence AnalysisAdd
    BLAST
    Transmembranei382 – 40221Helical; Name=10Sequence AnalysisAdd
    BLAST
    Transmembranei522 – 54221Helical; Name=11Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi455 – 4584Poly-Pro

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG331272.
    HOGENOMiHOG000013046.
    HOVERGENiHBG053519.
    InParanoidiQ96JT2.
    KOiK15379.
    OMAiPFIWALS.
    OrthoDBiEOG7R2BKR.
    PhylomeDBiQ96JT2.
    TreeFamiTF325412.

    Family and domain databases

    InterProiIPR011701. MFS.
    IPR016196. MFS_dom_general_subst_transpt.
    [Graphical view]
    PfamiPF07690. MFS_1. 1 hit.
    [Graphical view]
    SUPFAMiSSF103473. SSF103473. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q96JT2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVQRLWVSRL LRHRKAQLLL VNLLTFGLEV CLAAGITYVP PLLLEVGVEE    50
    KFMTMVLGIG PVLGLVCVPL LGSASDHWRG RYGRRRPFIW ALSLGILLSL 100
    FLIPRAGWLA GLLCPDPRPL ELALLILGVG LLDFCGQVCF TPLEALLSDL 150
    FRDPDHCRQA YSVYAFMISL GGCLGYLLPA IDWDTSALAP YLGTQEECLF 200
    GLLTLIFLTC VAATLLVAEE AALGPTEPAE GLSAPSLSPH CCPCRARLAF 250
    RNLGALLPRL HQLCCRMPRT LRRLFVAELC SWMALMTFTL FYTDFVGEGL 300
    YQGVPRAEPG TEARRHYDEG VRMGSLGLFL QCAISLVFSL VMDRLVQRFG 350
    TRAVYLASVA AFPVAAGATC LSHSVAVVTA SAALTGFTFS ALQILPYTLA 400
    SLYHREKQVF LPKYRGDTGG ASSEDSLMTS FLPGPKPGAP FPNGHVGAGG 450
    SGLLPPPPAL CGASACDVSV RVVVGEPTEA RVVPGRGICL DLAILDSAFL 500
    LSQVAPSLFM GSIVQLSQSV TAYMVSAAGL GLVAIYFATQ VVFDKSDLAK 550
    YSA 553
    Length:553
    Mass (Da):59,323
    Last modified:December 1, 2001 - v1
    Checksum:i0AFA23FBC742A667
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY033593 mRNA. Translation: AAK54386.1.
    AK290364 mRNA. Translation: BAF83053.1.
    AK313479 mRNA. Translation: BAG36263.1.
    CH471067 Genomic DNA. Translation: EAW91575.1.
    BC050416 mRNA. Translation: AAH50416.1.
    CCDSiCCDS1458.1.
    RefSeqiNP_149093.1. NM_033102.2.
    XP_005245613.1. XM_005245556.1.
    XP_005245614.1. XM_005245557.2.
    XP_005245615.1. XM_005245558.1.
    XP_005245616.1. XM_005245559.2.
    UniGeneiHs.278695.

    Genome annotation databases

    EnsembliENST00000367145; ENSP00000356113; ENSG00000158715.
    GeneIDi85414.
    KEGGihsa:85414.
    UCSCiuc001hda.1. human.

    Polymorphism databases

    DMDMi46396996.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY033593 mRNA. Translation: AAK54386.1 .
    AK290364 mRNA. Translation: BAF83053.1 .
    AK313479 mRNA. Translation: BAG36263.1 .
    CH471067 Genomic DNA. Translation: EAW91575.1 .
    BC050416 mRNA. Translation: AAH50416.1 .
    CCDSi CCDS1458.1.
    RefSeqi NP_149093.1. NM_033102.2.
    XP_005245613.1. XM_005245556.1.
    XP_005245614.1. XM_005245557.2.
    XP_005245615.1. XM_005245558.1.
    XP_005245616.1. XM_005245559.2.
    UniGenei Hs.278695.

    3D structure databases

    ProteinModelPortali Q96JT2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000356113.

    Protein family/group databases

    TCDBi 2.A.2.4.8. the glycoside-pentoside-hexuronide (gph):cation symporter family.

    PTM databases

    PhosphoSitei Q96JT2.

    Polymorphism databases

    DMDMi 46396996.

    Proteomic databases

    MaxQBi Q96JT2.
    PaxDbi Q96JT2.
    PRIDEi Q96JT2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000367145 ; ENSP00000356113 ; ENSG00000158715 .
    GeneIDi 85414.
    KEGGi hsa:85414.
    UCSCi uc001hda.1. human.

    Organism-specific databases

    CTDi 85414.
    GeneCardsi GC01M205626.
    HGNCi HGNC:8642. SLC45A3.
    HPAi HPA019073.
    HPA019075.
    MIMi 605097. gene.
    neXtProti NX_Q96JT2.
    PharmGKBi PA32981.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG331272.
    HOGENOMi HOG000013046.
    HOVERGENi HBG053519.
    InParanoidi Q96JT2.
    KOi K15379.
    OMAi PFIWALS.
    OrthoDBi EOG7R2BKR.
    PhylomeDBi Q96JT2.
    TreeFami TF325412.

    Miscellaneous databases

    ChiTaRSi SLC45A3. human.
    GeneWikii SLC45A3.
    GenomeRNAii 85414.
    NextBioi 75986.
    PROi Q96JT2.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q96JT2.
    Bgeei Q96JT2.
    CleanExi HS_SLC45A3.
    Genevestigatori Q96JT2.

    Family and domain databases

    InterProi IPR011701. MFS.
    IPR016196. MFS_dom_general_subst_transpt.
    [Graphical view ]
    Pfami PF07690. MFS_1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF103473. SSF103473. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Identification and characterization of prostein, a novel prostate-specific protein."
      Xu J., Kalos M., Stolk J.A., Zasloff E.J., Zhang X., Houghton R.L., Filho A.M., Nolasco M., Badaro R., Reed S.G.
      Cancer Res. 61:1563-1568(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, INDUCTION.
      Tissue: Prostate.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Thalamus and Tongue.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: PNS.
    5. "Identification of an HLA-A(*)0201-restricted T-cell epitope derived from the prostate cancer-associated protein prostein."
      Kiessling A., Stevanovic S., Fuessel S., Weigle B., Rieger M.A., Temme A., Rieber E.P., Schmitz M.
      Br. J. Cancer 90:1034-1040(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiS45A3_HUMAN
    AccessioniPrimary (citable) accession number: Q96JT2
    Secondary accession number(s): A8K2U9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 13, 2004
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 92 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    Marker for prostate cells. May be used, in case of prostate cancers, as a target antigen for prostate carcinomas-directed cytotoxic T-cell lymphocytes.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3