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Q96JT2 (S45A3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 90. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Solute carrier family 45 member 3
Alternative name(s):
Prostate cancer-associated protein 6
Prostein
Gene names
Name:SLC45A3
Synonyms:PCANAP6, PRST
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length553 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subcellular location

Membrane; Multi-pass membrane protein Potential.

Tissue specificity

Prostate specific. Expressed in all prostatic glandular cells. Expressed both in normal and cancerous prostates. Ref.1 Ref.5

Induction

Up-regulated by androgens. Ref.1

Miscellaneous

Marker for prostate cells. May be used, in case of prostate cancers, as a target antigen for prostate carcinomas-directed cytotoxic T-cell lymphocytes.

Sequence similarities

Belongs to the glycoside-pentoside-hexuronide (GPH) cation symporter transporter (TC 2.A.2) family. [View classification]

Ontologies

Keywords
   Biological processTransport
   Cellular componentMembrane
   DomainTransmembrane
Transmembrane helix
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processtransmembrane transport

Inferred from electronic annotation. Source: InterPro

   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 553553Solute carrier family 45 member 3
PRO_0000122519

Regions

Transmembrane19 – 3921Helical; Name=1; Potential
Transmembrane52 – 7221Helical; Name=2; Potential
Transmembrane88 – 10821Helical; Name=3; Potential
Transmembrane120 – 14021Helical; Name=4; Potential
Transmembrane161 – 18121Helical; Name=5; Potential
Transmembrane198 – 21821Helical; Name=6; Potential
Transmembrane275 – 29521Helical; Name=7; Potential
Transmembrane323 – 34321Helical; Name=8; Potential
Transmembrane353 – 37321Helical; Name=9; Potential
Transmembrane382 – 40221Helical; Name=10; Potential
Transmembrane522 – 54221Helical; Name=11; Potential
Compositional bias455 – 4584Poly-Pro

Sequences

Sequence LengthMass (Da)Tools
Q96JT2 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: 0AFA23FBC742A667

FASTA55359,323
        10         20         30         40         50         60 
MVQRLWVSRL LRHRKAQLLL VNLLTFGLEV CLAAGITYVP PLLLEVGVEE KFMTMVLGIG 

        70         80         90        100        110        120 
PVLGLVCVPL LGSASDHWRG RYGRRRPFIW ALSLGILLSL FLIPRAGWLA GLLCPDPRPL 

       130        140        150        160        170        180 
ELALLILGVG LLDFCGQVCF TPLEALLSDL FRDPDHCRQA YSVYAFMISL GGCLGYLLPA 

       190        200        210        220        230        240 
IDWDTSALAP YLGTQEECLF GLLTLIFLTC VAATLLVAEE AALGPTEPAE GLSAPSLSPH 

       250        260        270        280        290        300 
CCPCRARLAF RNLGALLPRL HQLCCRMPRT LRRLFVAELC SWMALMTFTL FYTDFVGEGL 

       310        320        330        340        350        360 
YQGVPRAEPG TEARRHYDEG VRMGSLGLFL QCAISLVFSL VMDRLVQRFG TRAVYLASVA 

       370        380        390        400        410        420 
AFPVAAGATC LSHSVAVVTA SAALTGFTFS ALQILPYTLA SLYHREKQVF LPKYRGDTGG 

       430        440        450        460        470        480 
ASSEDSLMTS FLPGPKPGAP FPNGHVGAGG SGLLPPPPAL CGASACDVSV RVVVGEPTEA 

       490        500        510        520        530        540 
RVVPGRGICL DLAILDSAFL LSQVAPSLFM GSIVQLSQSV TAYMVSAAGL GLVAIYFATQ 

       550 
VVFDKSDLAK YSA 

« Hide

References

« Hide 'large scale' references
[1]"Identification and characterization of prostein, a novel prostate-specific protein."
Xu J., Kalos M., Stolk J.A., Zasloff E.J., Zhang X., Houghton R.L., Filho A.M., Nolasco M., Badaro R., Reed S.G.
Cancer Res. 61:1563-1568(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, INDUCTION.
Tissue: Prostate.
[2]Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Thalamus and Tongue.
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: PNS.
[5]"Identification of an HLA-A(*)0201-restricted T-cell epitope derived from the prostate cancer-associated protein prostein."
Kiessling A., Stevanovic S., Fuessel S., Weigle B., Rieger M.A., Temme A., Rieber E.P., Schmitz M.
Br. J. Cancer 90:1034-1040(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY033593 mRNA. Translation: AAK54386.1.
AK290364 mRNA. Translation: BAF83053.1.
AK313479 mRNA. Translation: BAG36263.1.
CH471067 Genomic DNA. Translation: EAW91575.1.
BC050416 mRNA. Translation: AAH50416.1.
CCDSCCDS1458.1.
RefSeqNP_149093.1. NM_033102.2.
XP_005245613.1. XM_005245556.1.
XP_005245614.1. XM_005245557.2.
XP_005245615.1. XM_005245558.1.
XP_005245616.1. XM_005245559.2.
UniGeneHs.278695.

3D structure databases

ProteinModelPortalQ96JT2.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000356113.

Protein family/group databases

TCDB2.A.2.4.8. the glycoside-pentoside-hexuronide (gph):cation symporter family.

PTM databases

PhosphoSiteQ96JT2.

Polymorphism databases

DMDM46396996.

Proteomic databases

MaxQBQ96JT2.
PaxDbQ96JT2.
PRIDEQ96JT2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000367145; ENSP00000356113; ENSG00000158715.
GeneID85414.
KEGGhsa:85414.
UCSCuc001hda.1. human.

Organism-specific databases

CTD85414.
GeneCardsGC01M205626.
HGNCHGNC:8642. SLC45A3.
HPAHPA019073.
HPA019075.
MIM605097. gene.
neXtProtNX_Q96JT2.
PharmGKBPA32981.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG331272.
HOGENOMHOG000013046.
HOVERGENHBG053519.
InParanoidQ96JT2.
KOK15379.
OMAPFIWALS.
OrthoDBEOG7R2BKR.
PhylomeDBQ96JT2.
TreeFamTF325412.

Gene expression databases

ArrayExpressQ96JT2.
BgeeQ96JT2.
CleanExHS_SLC45A3.
GenevestigatorQ96JT2.

Family and domain databases

InterProIPR011701. MFS.
IPR016196. MFS_dom_general_subst_transpt.
[Graphical view]
PfamPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMSSF103473. SSF103473. 1 hit.
ProtoNetSearch...

Other

ChiTaRSSLC45A3. human.
GeneWikiSLC45A3.
GenomeRNAi85414.
NextBio75986.
PROQ96JT2.
SOURCESearch...

Entry information

Entry nameS45A3_HUMAN
AccessionPrimary (citable) accession number: Q96JT2
Secondary accession number(s): A8K2U9
Entry history
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: December 1, 2001
Last modified: July 9, 2014
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM