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Protein

Solute carrier family 45 member 3

Gene

SLC45A3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

  1. transmembrane transport Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Transport

Protein family/group databases

TCDBi2.A.2.4.8. the glycoside-pentoside-hexuronide (gph):cation symporter family.

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 45 member 3
Alternative name(s):
Prostate cancer-associated protein 6
Prostein
Gene namesi
Name:SLC45A3
Synonyms:PCANAP6, PRST
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:8642. SLC45A3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei19 – 3921Helical; Name=1Sequence AnalysisAdd
BLAST
Transmembranei52 – 7221Helical; Name=2Sequence AnalysisAdd
BLAST
Transmembranei88 – 10821Helical; Name=3Sequence AnalysisAdd
BLAST
Transmembranei120 – 14021Helical; Name=4Sequence AnalysisAdd
BLAST
Transmembranei161 – 18121Helical; Name=5Sequence AnalysisAdd
BLAST
Transmembranei198 – 21821Helical; Name=6Sequence AnalysisAdd
BLAST
Transmembranei275 – 29521Helical; Name=7Sequence AnalysisAdd
BLAST
Transmembranei323 – 34321Helical; Name=8Sequence AnalysisAdd
BLAST
Transmembranei353 – 37321Helical; Name=9Sequence AnalysisAdd
BLAST
Transmembranei382 – 40221Helical; Name=10Sequence AnalysisAdd
BLAST
Transmembranei522 – 54221Helical; Name=11Sequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32981.

Polymorphism and mutation databases

BioMutaiSLC45A3.
DMDMi46396996.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 553553Solute carrier family 45 member 3PRO_0000122519Add
BLAST

Proteomic databases

MaxQBiQ96JT2.
PaxDbiQ96JT2.
PRIDEiQ96JT2.

PTM databases

PhosphoSiteiQ96JT2.

Expressioni

Tissue specificityi

Prostate specific. Expressed in all prostatic glandular cells. Expressed both in normal and cancerous prostates.2 Publications

Inductioni

Up-regulated by androgens.1 Publication

Gene expression databases

BgeeiQ96JT2.
CleanExiHS_SLC45A3.
ExpressionAtlasiQ96JT2. baseline and differential.
GenevestigatoriQ96JT2.

Organism-specific databases

HPAiHPA019073.
HPA019075.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000356113.

Structurei

3D structure databases

ProteinModelPortaliQ96JT2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi455 – 4584Poly-Pro

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG331272.
GeneTreeiENSGT00390000018882.
HOGENOMiHOG000013046.
HOVERGENiHBG053519.
InParanoidiQ96JT2.
KOiK15379.
OMAiPFIWALS.
OrthoDBiEOG7R2BKR.
PhylomeDBiQ96JT2.
TreeFamiTF325412.

Family and domain databases

InterProiIPR011701. MFS.
IPR020846. MFS_dom.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.

Sequencei

Sequence statusi: Complete.

Q96JT2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVQRLWVSRL LRHRKAQLLL VNLLTFGLEV CLAAGITYVP PLLLEVGVEE
60 70 80 90 100
KFMTMVLGIG PVLGLVCVPL LGSASDHWRG RYGRRRPFIW ALSLGILLSL
110 120 130 140 150
FLIPRAGWLA GLLCPDPRPL ELALLILGVG LLDFCGQVCF TPLEALLSDL
160 170 180 190 200
FRDPDHCRQA YSVYAFMISL GGCLGYLLPA IDWDTSALAP YLGTQEECLF
210 220 230 240 250
GLLTLIFLTC VAATLLVAEE AALGPTEPAE GLSAPSLSPH CCPCRARLAF
260 270 280 290 300
RNLGALLPRL HQLCCRMPRT LRRLFVAELC SWMALMTFTL FYTDFVGEGL
310 320 330 340 350
YQGVPRAEPG TEARRHYDEG VRMGSLGLFL QCAISLVFSL VMDRLVQRFG
360 370 380 390 400
TRAVYLASVA AFPVAAGATC LSHSVAVVTA SAALTGFTFS ALQILPYTLA
410 420 430 440 450
SLYHREKQVF LPKYRGDTGG ASSEDSLMTS FLPGPKPGAP FPNGHVGAGG
460 470 480 490 500
SGLLPPPPAL CGASACDVSV RVVVGEPTEA RVVPGRGICL DLAILDSAFL
510 520 530 540 550
LSQVAPSLFM GSIVQLSQSV TAYMVSAAGL GLVAIYFATQ VVFDKSDLAK

YSA
Length:553
Mass (Da):59,323
Last modified:December 1, 2001 - v1
Checksum:i0AFA23FBC742A667
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY033593 mRNA. Translation: AAK54386.1.
AK290364 mRNA. Translation: BAF83053.1.
AK313479 mRNA. Translation: BAG36263.1.
CH471067 Genomic DNA. Translation: EAW91575.1.
BC050416 mRNA. Translation: AAH50416.1.
CCDSiCCDS1458.1.
RefSeqiNP_149093.1. NM_033102.2.
XP_005245613.1. XM_005245556.2.
XP_005245614.1. XM_005245557.3.
XP_005245616.1. XM_005245559.3.
UniGeneiHs.278695.

Genome annotation databases

EnsembliENST00000367145; ENSP00000356113; ENSG00000158715.
GeneIDi85414.
KEGGihsa:85414.
UCSCiuc001hda.1. human.

Polymorphism and mutation databases

BioMutaiSLC45A3.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY033593 mRNA. Translation: AAK54386.1.
AK290364 mRNA. Translation: BAF83053.1.
AK313479 mRNA. Translation: BAG36263.1.
CH471067 Genomic DNA. Translation: EAW91575.1.
BC050416 mRNA. Translation: AAH50416.1.
CCDSiCCDS1458.1.
RefSeqiNP_149093.1. NM_033102.2.
XP_005245613.1. XM_005245556.2.
XP_005245614.1. XM_005245557.3.
XP_005245616.1. XM_005245559.3.
UniGeneiHs.278695.

3D structure databases

ProteinModelPortaliQ96JT2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000356113.

Protein family/group databases

TCDBi2.A.2.4.8. the glycoside-pentoside-hexuronide (gph):cation symporter family.

PTM databases

PhosphoSiteiQ96JT2.

Polymorphism and mutation databases

BioMutaiSLC45A3.
DMDMi46396996.

Proteomic databases

MaxQBiQ96JT2.
PaxDbiQ96JT2.
PRIDEiQ96JT2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000367145; ENSP00000356113; ENSG00000158715.
GeneIDi85414.
KEGGihsa:85414.
UCSCiuc001hda.1. human.

Organism-specific databases

CTDi85414.
GeneCardsiGC01M205626.
HGNCiHGNC:8642. SLC45A3.
HPAiHPA019073.
HPA019075.
MIMi605097. gene.
neXtProtiNX_Q96JT2.
PharmGKBiPA32981.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG331272.
GeneTreeiENSGT00390000018882.
HOGENOMiHOG000013046.
HOVERGENiHBG053519.
InParanoidiQ96JT2.
KOiK15379.
OMAiPFIWALS.
OrthoDBiEOG7R2BKR.
PhylomeDBiQ96JT2.
TreeFamiTF325412.

Miscellaneous databases

ChiTaRSiSLC45A3. human.
GeneWikiiSLC45A3.
GenomeRNAii85414.
NextBioi75986.
PROiQ96JT2.
SOURCEiSearch...

Gene expression databases

BgeeiQ96JT2.
CleanExiHS_SLC45A3.
ExpressionAtlasiQ96JT2. baseline and differential.
GenevestigatoriQ96JT2.

Family and domain databases

InterProiIPR011701. MFS.
IPR020846. MFS_dom.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification and characterization of prostein, a novel prostate-specific protein."
    Xu J., Kalos M., Stolk J.A., Zasloff E.J., Zhang X., Houghton R.L., Filho A.M., Nolasco M., Badaro R., Reed S.G.
    Cancer Res. 61:1563-1568(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, INDUCTION.
    Tissue: Prostate.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Thalamus and Tongue.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: PNS.
  5. "Identification of an HLA-A(*)0201-restricted T-cell epitope derived from the prostate cancer-associated protein prostein."
    Kiessling A., Stevanovic S., Fuessel S., Weigle B., Rieger M.A., Temme A., Rieber E.P., Schmitz M.
    Br. J. Cancer 90:1034-1040(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiS45A3_HUMAN
AccessioniPrimary (citable) accession number: Q96JT2
Secondary accession number(s): A8K2U9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: December 1, 2001
Last modified: April 29, 2015
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Marker for prostate cells. May be used, in case of prostate cancers, as a target antigen for prostate carcinomas-directed cytotoxic T-cell lymphocytes.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.