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Q96JT2

- S45A3_HUMAN

UniProt

Q96JT2 - S45A3_HUMAN

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Protein

Solute carrier family 45 member 3

Gene
SLC45A3, PCANAP6, PRST
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

GO - Biological processi

  1. transmembrane transport Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Transport

Protein family/group databases

TCDBi2.A.2.4.8. the glycoside-pentoside-hexuronide (gph):cation symporter family.

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 45 member 3
Alternative name(s):
Prostate cancer-associated protein 6
Prostein
Gene namesi
Name:SLC45A3
Synonyms:PCANAP6, PRST
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:8642. SLC45A3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei19 – 3921Helical; Name=1; Reviewed predictionAdd
BLAST
Transmembranei52 – 7221Helical; Name=2; Reviewed predictionAdd
BLAST
Transmembranei88 – 10821Helical; Name=3; Reviewed predictionAdd
BLAST
Transmembranei120 – 14021Helical; Name=4; Reviewed predictionAdd
BLAST
Transmembranei161 – 18121Helical; Name=5; Reviewed predictionAdd
BLAST
Transmembranei198 – 21821Helical; Name=6; Reviewed predictionAdd
BLAST
Transmembranei275 – 29521Helical; Name=7; Reviewed predictionAdd
BLAST
Transmembranei323 – 34321Helical; Name=8; Reviewed predictionAdd
BLAST
Transmembranei353 – 37321Helical; Name=9; Reviewed predictionAdd
BLAST
Transmembranei382 – 40221Helical; Name=10; Reviewed predictionAdd
BLAST
Transmembranei522 – 54221Helical; Name=11; Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32981.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 553553Solute carrier family 45 member 3PRO_0000122519Add
BLAST

Proteomic databases

MaxQBiQ96JT2.
PaxDbiQ96JT2.
PRIDEiQ96JT2.

PTM databases

PhosphoSiteiQ96JT2.

Expressioni

Tissue specificityi

Prostate specific. Expressed in all prostatic glandular cells. Expressed both in normal and cancerous prostates.2 Publications

Inductioni

Up-regulated by androgens.1 Publication

Gene expression databases

ArrayExpressiQ96JT2.
BgeeiQ96JT2.
CleanExiHS_SLC45A3.
GenevestigatoriQ96JT2.

Organism-specific databases

HPAiHPA019073.
HPA019075.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000356113.

Structurei

3D structure databases

ProteinModelPortaliQ96JT2.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi455 – 4584Poly-Pro

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG331272.
HOGENOMiHOG000013046.
HOVERGENiHBG053519.
InParanoidiQ96JT2.
KOiK15379.
OMAiPFIWALS.
OrthoDBiEOG7R2BKR.
PhylomeDBiQ96JT2.
TreeFamiTF325412.

Family and domain databases

InterProiIPR011701. MFS.
IPR016196. MFS_dom_general_subst_transpt.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.

Sequencei

Sequence statusi: Complete.

Q96JT2-1 [UniParc]FASTAAdd to Basket

« Hide

MVQRLWVSRL LRHRKAQLLL VNLLTFGLEV CLAAGITYVP PLLLEVGVEE    50
KFMTMVLGIG PVLGLVCVPL LGSASDHWRG RYGRRRPFIW ALSLGILLSL 100
FLIPRAGWLA GLLCPDPRPL ELALLILGVG LLDFCGQVCF TPLEALLSDL 150
FRDPDHCRQA YSVYAFMISL GGCLGYLLPA IDWDTSALAP YLGTQEECLF 200
GLLTLIFLTC VAATLLVAEE AALGPTEPAE GLSAPSLSPH CCPCRARLAF 250
RNLGALLPRL HQLCCRMPRT LRRLFVAELC SWMALMTFTL FYTDFVGEGL 300
YQGVPRAEPG TEARRHYDEG VRMGSLGLFL QCAISLVFSL VMDRLVQRFG 350
TRAVYLASVA AFPVAAGATC LSHSVAVVTA SAALTGFTFS ALQILPYTLA 400
SLYHREKQVF LPKYRGDTGG ASSEDSLMTS FLPGPKPGAP FPNGHVGAGG 450
SGLLPPPPAL CGASACDVSV RVVVGEPTEA RVVPGRGICL DLAILDSAFL 500
LSQVAPSLFM GSIVQLSQSV TAYMVSAAGL GLVAIYFATQ VVFDKSDLAK 550
YSA 553
Length:553
Mass (Da):59,323
Last modified:December 1, 2001 - v1
Checksum:i0AFA23FBC742A667
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY033593 mRNA. Translation: AAK54386.1.
AK290364 mRNA. Translation: BAF83053.1.
AK313479 mRNA. Translation: BAG36263.1.
CH471067 Genomic DNA. Translation: EAW91575.1.
BC050416 mRNA. Translation: AAH50416.1.
CCDSiCCDS1458.1.
RefSeqiNP_149093.1. NM_033102.2.
XP_005245613.1. XM_005245556.1.
XP_005245614.1. XM_005245557.2.
XP_005245615.1. XM_005245558.1.
XP_005245616.1. XM_005245559.2.
UniGeneiHs.278695.

Genome annotation databases

EnsembliENST00000367145; ENSP00000356113; ENSG00000158715.
GeneIDi85414.
KEGGihsa:85414.
UCSCiuc001hda.1. human.

Polymorphism databases

DMDMi46396996.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY033593 mRNA. Translation: AAK54386.1 .
AK290364 mRNA. Translation: BAF83053.1 .
AK313479 mRNA. Translation: BAG36263.1 .
CH471067 Genomic DNA. Translation: EAW91575.1 .
BC050416 mRNA. Translation: AAH50416.1 .
CCDSi CCDS1458.1.
RefSeqi NP_149093.1. NM_033102.2.
XP_005245613.1. XM_005245556.1.
XP_005245614.1. XM_005245557.2.
XP_005245615.1. XM_005245558.1.
XP_005245616.1. XM_005245559.2.
UniGenei Hs.278695.

3D structure databases

ProteinModelPortali Q96JT2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000356113.

Protein family/group databases

TCDBi 2.A.2.4.8. the glycoside-pentoside-hexuronide (gph):cation symporter family.

PTM databases

PhosphoSitei Q96JT2.

Polymorphism databases

DMDMi 46396996.

Proteomic databases

MaxQBi Q96JT2.
PaxDbi Q96JT2.
PRIDEi Q96JT2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000367145 ; ENSP00000356113 ; ENSG00000158715 .
GeneIDi 85414.
KEGGi hsa:85414.
UCSCi uc001hda.1. human.

Organism-specific databases

CTDi 85414.
GeneCardsi GC01M205626.
HGNCi HGNC:8642. SLC45A3.
HPAi HPA019073.
HPA019075.
MIMi 605097. gene.
neXtProti NX_Q96JT2.
PharmGKBi PA32981.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG331272.
HOGENOMi HOG000013046.
HOVERGENi HBG053519.
InParanoidi Q96JT2.
KOi K15379.
OMAi PFIWALS.
OrthoDBi EOG7R2BKR.
PhylomeDBi Q96JT2.
TreeFami TF325412.

Miscellaneous databases

ChiTaRSi SLC45A3. human.
GeneWikii SLC45A3.
GenomeRNAii 85414.
NextBioi 75986.
PROi Q96JT2.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q96JT2.
Bgeei Q96JT2.
CleanExi HS_SLC45A3.
Genevestigatori Q96JT2.

Family and domain databases

InterProi IPR011701. MFS.
IPR016196. MFS_dom_general_subst_transpt.
[Graphical view ]
Pfami PF07690. MFS_1. 1 hit.
[Graphical view ]
SUPFAMi SSF103473. SSF103473. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification and characterization of prostein, a novel prostate-specific protein."
    Xu J., Kalos M., Stolk J.A., Zasloff E.J., Zhang X., Houghton R.L., Filho A.M., Nolasco M., Badaro R., Reed S.G.
    Cancer Res. 61:1563-1568(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, INDUCTION.
    Tissue: Prostate.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Thalamus and Tongue.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: PNS.
  5. "Identification of an HLA-A(*)0201-restricted T-cell epitope derived from the prostate cancer-associated protein prostein."
    Kiessling A., Stevanovic S., Fuessel S., Weigle B., Rieger M.A., Temme A., Rieber E.P., Schmitz M.
    Br. J. Cancer 90:1034-1040(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiS45A3_HUMAN
AccessioniPrimary (citable) accession number: Q96JT2
Secondary accession number(s): A8K2U9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: December 1, 2001
Last modified: September 3, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Marker for prostate cells. May be used, in case of prostate cancers, as a target antigen for prostate carcinomas-directed cytotoxic T-cell lymphocytes.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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