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Protein

PiggyBac transposable element-derived protein 1

Gene

PGBD1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
PiggyBac transposable element-derived protein 1
Alternative name(s):
Cerebral protein 4
Gene namesi
Name:PGBD1
ORF Names:hucep-4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:19398. PGBD1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134919893.

Polymorphism and mutation databases

BioMutaiPGBD1.
DMDMi74751967.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 809809PiggyBac transposable element-derived protein 1PRO_0000288052Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei360 – 3601PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ96JS3.
PaxDbiQ96JS3.
PRIDEiQ96JS3.

PTM databases

iPTMnetiQ96JS3.
PhosphoSiteiQ96JS3.

Expressioni

Gene expression databases

BgeeiQ96JS3.
CleanExiHS_PGBD1.
GenevisibleiQ96JS3. HS.

Organism-specific databases

HPAiHPA007267.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
MEOX2A4D1273EBI-10290053,EBI-10172134
NR4A1P227363EBI-10290053,EBI-721550
SCAND1P570863EBI-10290053,EBI-745846
TRAF2Q129333EBI-10290053,EBI-355744
ZNF24P170283EBI-10290053,EBI-707773
ZNF446Q96AF53EBI-10290053,EBI-740232
ZSCAN22P100734EBI-10290053,EBI-10178224

Protein-protein interaction databases

BioGridi124132. 24 interactions.
IntActiQ96JS3. 7 interactions.
STRINGi9606.ENSP00000259883.

Structurei

3D structure databases

ProteinModelPortaliQ96JS3.
SMRiQ96JS3. Positions 41-124.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini44 – 12683SCAN boxPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 SCAN box domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IHMN. Eukaryota.
ENOG410ZDPG. LUCA.
GeneTreeiENSGT00530000063278.
HOGENOMiHOG000115518.
HOVERGENiHBG099853.
InParanoidiQ96JS3.
OMAiHRACNPG.
OrthoDBiEOG78WKR6.
PhylomeDBiQ96JS3.
TreeFamiTF328011.

Family and domain databases

InterProiIPR029526. PGBD.
IPR008916. Retrov_capsid_C.
IPR003309. SCAN_dom.
IPR001190. SRCR.
[Graphical view]
PfamiPF13843. DDE_Tnp_1_7. 1 hit.
PF02023. SCAN. 1 hit.
[Graphical view]
SMARTiSM00431. SCAN. 1 hit.
[Graphical view]
SUPFAMiSSF47353. SSF47353. 1 hit.
PROSITEiPS50804. SCAN_BOX. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96JS3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYEALPGPAP ENEDGLVKVK EEDPTWEQVC NSQEGSSHTQ EICRLRFRHF
60 70 80 90 100
CYQEAHGPQE ALAQLRELCH QWLRPEMHTK EQIMELLVLE QFLTILPKEL
110 120 130 140 150
QPCVKTYPLE SGEEAVTVLE NLETGSGDTG QQASVYIQGQ DMHPMVAEYQ
160 170 180 190 200
GVSLECQSLQ LLPGITTLKC EPPQRPQGNP QEVSGPVPHG SAHLQEKNPR
210 220 230 240 250
DKAVVPVFNP VRSQTLVKTE EETAQAVAAE KWSHLSLTRR NLCGNSAQET
260 270 280 290 300
VMSLSPMTEE IVTKDRLFKA KQETSEEMEQ SGEASGKPNR ECAPQIPCST
310 320 330 340 350
PIATERTVAH LNTLKDRHPG DLWARMHISS LEYAAGDITR KGRKKDKARV
360 370 380 390 400
SELLQGLSFS GDSDVEKDNE PEIQPAQKKL KVSCFPEKSW TKRDIKPNFP
410 420 430 440 450
SWSALDSGLL NLKSEKLNPV ELFELFFDDE TFNLIVNETN NYASQKNVSL
460 470 480 490 500
EVTVQEMRCV FGVLLLSGFM RHPRREMYWE VSDTDQNLVR DAIRRDRFEL
510 520 530 540 550
IFSNLHFADN GHLDQKDKFT KLRPLIKQMN KNFLLYAPLE EYYCFDKSMC
560 570 580 590 600
ECFDSDQFLN GKPIRIGYKI WCGTTTQGYL VWFEPYQEES TMKVDEDPDL
610 620 630 640 650
GLGGNLVMNF ADVLLERGQY PYHLCFDSFF TSVKLLSALK KKGVRATGTI
660 670 680 690 700
RENRTEKCPL MNVEHMKKMK RGYFDFRIEE NNEIILCRWY GDGIISLCSN
710 720 730 740 750
AVGIEPVNEV SCCDADNEEI PQISQPSIVK VYDECKEGVA KMDQIISKYR
760 770 780 790 800
VRIRSKKWYS ILVSYMIDVA MNNAWQLHRA CNPGASLDPL DFRRFVAHFY

LEHNAHLSD
Length:809
Mass (Da):92,515
Last modified:December 1, 2001 - v1
Checksum:iB311C58D171ABF3E
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti99 – 991E → G in BAD97166 (Ref. 2) Curated
Sequence conflicti493 – 4931I → V in BAD97166 (Ref. 2) Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti244 – 2441G → E.
Corresponds to variant rs3800324 [ dbSNP | Ensembl ].
VAR_032384
Natural varianti244 – 2441G → R.
Corresponds to variant rs3800324 [ dbSNP | Ensembl ].
VAR_051273
Natural varianti248 – 2481Q → E.
Corresponds to variant rs3800325 [ dbSNP | Ensembl ].
VAR_032385
Natural varianti256 – 2561P → L.
Corresponds to variant rs3800326 [ dbSNP | Ensembl ].
VAR_032386
Natural varianti398 – 3981N → S.
Corresponds to variant rs33932084 [ dbSNP | Ensembl ].
VAR_032387
Natural varianti592 – 5921M → I.
Corresponds to variant rs16893917 [ dbSNP | Ensembl ].
VAR_032388
Natural varianti678 – 6781I → V.
Corresponds to variant rs1997660 [ dbSNP | Ensembl ].
VAR_032389
Natural varianti806 – 8061H → D.
Corresponds to variant rs6456811 [ dbSNP | Ensembl ].
VAR_032390

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D88259 mRNA. Translation: BAB46919.1.
AK223446 mRNA. Translation: BAD97166.1.
AL021997 Genomic DNA. Translation: CAD21704.2.
BC069033 mRNA. Translation: AAH69033.1. Different termination.
BC128585 mRNA. Translation: AAI28586.1.
CCDSiCCDS4648.1.
RefSeqiNP_001171672.1. NM_001184743.1.
NP_115896.1. NM_032507.3.
UniGeneiHs.144527.

Genome annotation databases

EnsembliENST00000259883; ENSP00000259883; ENSG00000137338.
GeneIDi84547.
KEGGihsa:84547.
UCSCiuc003nkz.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D88259 mRNA. Translation: BAB46919.1.
AK223446 mRNA. Translation: BAD97166.1.
AL021997 Genomic DNA. Translation: CAD21704.2.
BC069033 mRNA. Translation: AAH69033.1. Different termination.
BC128585 mRNA. Translation: AAI28586.1.
CCDSiCCDS4648.1.
RefSeqiNP_001171672.1. NM_001184743.1.
NP_115896.1. NM_032507.3.
UniGeneiHs.144527.

3D structure databases

ProteinModelPortaliQ96JS3.
SMRiQ96JS3. Positions 41-124.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124132. 24 interactions.
IntActiQ96JS3. 7 interactions.
STRINGi9606.ENSP00000259883.

PTM databases

iPTMnetiQ96JS3.
PhosphoSiteiQ96JS3.

Polymorphism and mutation databases

BioMutaiPGBD1.
DMDMi74751967.

Proteomic databases

MaxQBiQ96JS3.
PaxDbiQ96JS3.
PRIDEiQ96JS3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000259883; ENSP00000259883; ENSG00000137338.
GeneIDi84547.
KEGGihsa:84547.
UCSCiuc003nkz.4. human.

Organism-specific databases

CTDi84547.
GeneCardsiPGBD1.
HGNCiHGNC:19398. PGBD1.
HPAiHPA007267.
neXtProtiNX_Q96JS3.
PharmGKBiPA134919893.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IHMN. Eukaryota.
ENOG410ZDPG. LUCA.
GeneTreeiENSGT00530000063278.
HOGENOMiHOG000115518.
HOVERGENiHBG099853.
InParanoidiQ96JS3.
OMAiHRACNPG.
OrthoDBiEOG78WKR6.
PhylomeDBiQ96JS3.
TreeFamiTF328011.

Miscellaneous databases

GenomeRNAii84547.
PROiQ96JS3.

Gene expression databases

BgeeiQ96JS3.
CleanExiHS_PGBD1.
GenevisibleiQ96JS3. HS.

Family and domain databases

InterProiIPR029526. PGBD.
IPR008916. Retrov_capsid_C.
IPR003309. SCAN_dom.
IPR001190. SRCR.
[Graphical view]
PfamiPF13843. DDE_Tnp_1_7. 1 hit.
PF02023. SCAN. 1 hit.
[Graphical view]
SMARTiSM00431. SCAN. 1 hit.
[Graphical view]
SUPFAMiSSF47353. SSF47353. 1 hit.
PROSITEiPS50804. SCAN_BOX. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Biological functions of a novel human gene, hucep-4, which is specifically expressed in the central nervous system."
    Yoshimoto M., Yazaki M., Takayama K., Matsumoto K.
    Submitted (OCT-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  2. Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
    Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  3. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Liver.
  5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-360, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.

Entry informationi

Entry nameiPGBD1_HUMAN
AccessioniPrimary (citable) accession number: Q96JS3
Secondary accession number(s): Q53F43, Q6NTF5, Q8WWS4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: December 1, 2001
Last modified: June 8, 2016
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.