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Protein

PiggyBac transposable element-derived protein 1

Gene

PGBD1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Recommended name:
PiggyBac transposable element-derived protein 1
Alternative name(s):
Cerebral protein 4
Gene namesi
Name:PGBD1
ORF Names:hucep-4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000137338.5
HGNCiHGNC:19398 PGBD1
neXtProtiNX_Q96JS3

Subcellular locationi

Pathology & Biotechi

Organism-specific databases

DisGeNETi84547
OpenTargetsiENSG00000137338
PharmGKBiPA134919893

Polymorphism and mutation databases

BioMutaiPGBD1
DMDMi74751967

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002880521 – 809PiggyBac transposable element-derived protein 1Add BLAST809

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki218Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei360PhosphoserineCombined sources1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ96JS3
MaxQBiQ96JS3
PaxDbiQ96JS3
PeptideAtlasiQ96JS3
PRIDEiQ96JS3

PTM databases

iPTMnetiQ96JS3
PhosphoSitePlusiQ96JS3

Expressioni

Gene expression databases

BgeeiENSG00000137338
CleanExiHS_PGBD1
GenevisibleiQ96JS3 HS

Organism-specific databases

HPAiHPA007267

Interactioni

Binary interactionsi

Show more details

GO - Molecular functioni

  • identical protein binding Source: IntAct

Protein-protein interaction databases

BioGridi124132, 24 interactors
IntActiQ96JS3, 13 interactors
STRINGi9606.ENSP00000259883

Structurei

3D structure databases

ProteinModelPortaliQ96JS3
SMRiQ96JS3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini44 – 126SCAN boxPROSITE-ProRule annotationAdd BLAST83

Phylogenomic databases

eggNOGiENOG410IHMN Eukaryota
ENOG410ZDPG LUCA
GeneTreeiENSGT00530000063278
HOGENOMiHOG000115518
HOVERGENiHBG099853
InParanoidiQ96JS3
OMAiEDPTWEQ
OrthoDBiEOG091G05IL
PhylomeDBiQ96JS3
TreeFamiTF328011

Family and domain databases

CDDicd07936 SCAN, 1 hit
Gene3Di1.10.4020.10, 1 hit
InterProiView protein in InterPro
IPR029526 PGBD
IPR003309 SCAN_dom
IPR038269 SCAN_sf
IPR001190 SRCR
PfamiView protein in Pfam
PF13843 DDE_Tnp_1_7, 1 hit
PF02023 SCAN, 1 hit
SMARTiView protein in SMART
SM00431 SCAN, 1 hit
PROSITEiView protein in PROSITE
PS50804 SCAN_BOX, 1 hit

Sequencei

Sequence statusi: Complete.

Q96JS3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYEALPGPAP ENEDGLVKVK EEDPTWEQVC NSQEGSSHTQ EICRLRFRHF
60 70 80 90 100
CYQEAHGPQE ALAQLRELCH QWLRPEMHTK EQIMELLVLE QFLTILPKEL
110 120 130 140 150
QPCVKTYPLE SGEEAVTVLE NLETGSGDTG QQASVYIQGQ DMHPMVAEYQ
160 170 180 190 200
GVSLECQSLQ LLPGITTLKC EPPQRPQGNP QEVSGPVPHG SAHLQEKNPR
210 220 230 240 250
DKAVVPVFNP VRSQTLVKTE EETAQAVAAE KWSHLSLTRR NLCGNSAQET
260 270 280 290 300
VMSLSPMTEE IVTKDRLFKA KQETSEEMEQ SGEASGKPNR ECAPQIPCST
310 320 330 340 350
PIATERTVAH LNTLKDRHPG DLWARMHISS LEYAAGDITR KGRKKDKARV
360 370 380 390 400
SELLQGLSFS GDSDVEKDNE PEIQPAQKKL KVSCFPEKSW TKRDIKPNFP
410 420 430 440 450
SWSALDSGLL NLKSEKLNPV ELFELFFDDE TFNLIVNETN NYASQKNVSL
460 470 480 490 500
EVTVQEMRCV FGVLLLSGFM RHPRREMYWE VSDTDQNLVR DAIRRDRFEL
510 520 530 540 550
IFSNLHFADN GHLDQKDKFT KLRPLIKQMN KNFLLYAPLE EYYCFDKSMC
560 570 580 590 600
ECFDSDQFLN GKPIRIGYKI WCGTTTQGYL VWFEPYQEES TMKVDEDPDL
610 620 630 640 650
GLGGNLVMNF ADVLLERGQY PYHLCFDSFF TSVKLLSALK KKGVRATGTI
660 670 680 690 700
RENRTEKCPL MNVEHMKKMK RGYFDFRIEE NNEIILCRWY GDGIISLCSN
710 720 730 740 750
AVGIEPVNEV SCCDADNEEI PQISQPSIVK VYDECKEGVA KMDQIISKYR
760 770 780 790 800
VRIRSKKWYS ILVSYMIDVA MNNAWQLHRA CNPGASLDPL DFRRFVAHFY

LEHNAHLSD
Length:809
Mass (Da):92,515
Last modified:December 1, 2001 - v1
Checksum:iB311C58D171ABF3E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti99E → G in BAD97166 (Ref. 2) Curated1
Sequence conflicti493I → V in BAD97166 (Ref. 2) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_032384244G → E. Corresponds to variant dbSNP:rs3800324Ensembl.1
Natural variantiVAR_051273244G → R. Corresponds to variant dbSNP:rs3800324Ensembl.1
Natural variantiVAR_032385248Q → E. Corresponds to variant dbSNP:rs3800325Ensembl.1
Natural variantiVAR_032386256P → L. Corresponds to variant dbSNP:rs3800326Ensembl.1
Natural variantiVAR_032387398N → S. Corresponds to variant dbSNP:rs33932084Ensembl.1
Natural variantiVAR_032388592M → I. Corresponds to variant dbSNP:rs16893917Ensembl.1
Natural variantiVAR_032389678I → V. Corresponds to variant dbSNP:rs1997660Ensembl.1
Natural variantiVAR_032390806H → D. Corresponds to variant dbSNP:rs6456811Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D88259 mRNA Translation: BAB46919.1
AK223446 mRNA Translation: BAD97166.1
AL021997 Genomic DNA No translation available.
BC069033 mRNA Translation: AAH69033.1 Different termination.
BC128585 mRNA Translation: AAI28586.1
CCDSiCCDS4648.1
RefSeqiNP_001171672.1, NM_001184743.1
NP_115896.1, NM_032507.3
XP_016866850.1, XM_017011361.1
UniGeneiHs.144527

Genome annotation databases

EnsembliENST00000259883; ENSP00000259883; ENSG00000137338
GeneIDi84547
KEGGihsa:84547
UCSCiuc003nkz.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiPGBD1_HUMAN
AccessioniPrimary (citable) accession number: Q96JS3
Secondary accession number(s): Q53F43, Q6NTF5, Q8WWS4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: December 1, 2001
Last modified: March 28, 2018
This is version 120 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health