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Protein

PiggyBac transposable element-derived protein 1

Gene

PGBD1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000137338-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
PiggyBac transposable element-derived protein 1
Alternative name(s):
Cerebral protein 4
Gene namesi
Name:PGBD1
ORF Names:hucep-4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:19398. PGBD1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

DisGeNETi84547.
OpenTargetsiENSG00000137338.
PharmGKBiPA134919893.

Polymorphism and mutation databases

BioMutaiPGBD1.
DMDMi74751967.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002880521 – 809PiggyBac transposable element-derived protein 1Add BLAST809

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei360PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ96JS3.
MaxQBiQ96JS3.
PaxDbiQ96JS3.
PeptideAtlasiQ96JS3.
PRIDEiQ96JS3.

PTM databases

iPTMnetiQ96JS3.
PhosphoSitePlusiQ96JS3.

Expressioni

Gene expression databases

BgeeiENSG00000137338.
CleanExiHS_PGBD1.
GenevisibleiQ96JS3. HS.

Organism-specific databases

HPAiHPA007267.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
itself3EBI-10290053,EBI-10290053
MEOX2A4D1273EBI-10290053,EBI-10172134
NR4A1P227363EBI-10290053,EBI-721550
SCAND1P570865EBI-10290053,EBI-745846
TRAF2Q129333EBI-10290053,EBI-355744
ZNF24P170283EBI-10290053,EBI-707773
ZNF446A0A087WUM84EBI-10290053,EBI-11955977
ZNF446Q96AF53EBI-10290053,EBI-740232
ZSCAN22P100734EBI-10290053,EBI-10178224

Protein-protein interaction databases

BioGridi124132. 24 interactors.
IntActiQ96JS3. 11 interactors.
STRINGi9606.ENSP00000259883.

Structurei

3D structure databases

ProteinModelPortaliQ96JS3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini44 – 126SCAN boxPROSITE-ProRule annotationAdd BLAST83

Sequence similaritiesi

Contains 1 SCAN box domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IHMN. Eukaryota.
ENOG410ZDPG. LUCA.
GeneTreeiENSGT00530000063278.
HOGENOMiHOG000115518.
HOVERGENiHBG099853.
InParanoidiQ96JS3.
OMAiHRACNPG.
OrthoDBiEOG091G05IL.
PhylomeDBiQ96JS3.
TreeFamiTF328011.

Family and domain databases

InterProiIPR029526. PGBD.
IPR008916. Retrov_capsid_C.
IPR003309. SCAN_dom.
IPR001190. SRCR.
[Graphical view]
PfamiPF13843. DDE_Tnp_1_7. 1 hit.
PF02023. SCAN. 1 hit.
[Graphical view]
SMARTiSM00431. SCAN. 1 hit.
[Graphical view]
SUPFAMiSSF47353. SSF47353. 1 hit.
PROSITEiPS50804. SCAN_BOX. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96JS3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYEALPGPAP ENEDGLVKVK EEDPTWEQVC NSQEGSSHTQ EICRLRFRHF
60 70 80 90 100
CYQEAHGPQE ALAQLRELCH QWLRPEMHTK EQIMELLVLE QFLTILPKEL
110 120 130 140 150
QPCVKTYPLE SGEEAVTVLE NLETGSGDTG QQASVYIQGQ DMHPMVAEYQ
160 170 180 190 200
GVSLECQSLQ LLPGITTLKC EPPQRPQGNP QEVSGPVPHG SAHLQEKNPR
210 220 230 240 250
DKAVVPVFNP VRSQTLVKTE EETAQAVAAE KWSHLSLTRR NLCGNSAQET
260 270 280 290 300
VMSLSPMTEE IVTKDRLFKA KQETSEEMEQ SGEASGKPNR ECAPQIPCST
310 320 330 340 350
PIATERTVAH LNTLKDRHPG DLWARMHISS LEYAAGDITR KGRKKDKARV
360 370 380 390 400
SELLQGLSFS GDSDVEKDNE PEIQPAQKKL KVSCFPEKSW TKRDIKPNFP
410 420 430 440 450
SWSALDSGLL NLKSEKLNPV ELFELFFDDE TFNLIVNETN NYASQKNVSL
460 470 480 490 500
EVTVQEMRCV FGVLLLSGFM RHPRREMYWE VSDTDQNLVR DAIRRDRFEL
510 520 530 540 550
IFSNLHFADN GHLDQKDKFT KLRPLIKQMN KNFLLYAPLE EYYCFDKSMC
560 570 580 590 600
ECFDSDQFLN GKPIRIGYKI WCGTTTQGYL VWFEPYQEES TMKVDEDPDL
610 620 630 640 650
GLGGNLVMNF ADVLLERGQY PYHLCFDSFF TSVKLLSALK KKGVRATGTI
660 670 680 690 700
RENRTEKCPL MNVEHMKKMK RGYFDFRIEE NNEIILCRWY GDGIISLCSN
710 720 730 740 750
AVGIEPVNEV SCCDADNEEI PQISQPSIVK VYDECKEGVA KMDQIISKYR
760 770 780 790 800
VRIRSKKWYS ILVSYMIDVA MNNAWQLHRA CNPGASLDPL DFRRFVAHFY

LEHNAHLSD
Length:809
Mass (Da):92,515
Last modified:December 1, 2001 - v1
Checksum:iB311C58D171ABF3E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti99E → G in BAD97166 (Ref. 2) Curated1
Sequence conflicti493I → V in BAD97166 (Ref. 2) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_032384244G → E.Corresponds to variant rs3800324dbSNPEnsembl.1
Natural variantiVAR_051273244G → R.Corresponds to variant rs3800324dbSNPEnsembl.1
Natural variantiVAR_032385248Q → E.Corresponds to variant rs3800325dbSNPEnsembl.1
Natural variantiVAR_032386256P → L.Corresponds to variant rs3800326dbSNPEnsembl.1
Natural variantiVAR_032387398N → S.Corresponds to variant rs33932084dbSNPEnsembl.1
Natural variantiVAR_032388592M → I.Corresponds to variant rs16893917dbSNPEnsembl.1
Natural variantiVAR_032389678I → V.Corresponds to variant rs1997660dbSNPEnsembl.1
Natural variantiVAR_032390806H → D.Corresponds to variant rs6456811dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D88259 mRNA. Translation: BAB46919.1.
AK223446 mRNA. Translation: BAD97166.1.
AL021997 Genomic DNA. Translation: CAD21704.2.
BC069033 mRNA. Translation: AAH69033.1. Different termination.
BC128585 mRNA. Translation: AAI28586.1.
CCDSiCCDS4648.1.
RefSeqiNP_001171672.1. NM_001184743.1.
NP_115896.1. NM_032507.3.
XP_016866850.1. XM_017011361.1.
UniGeneiHs.144527.

Genome annotation databases

EnsembliENST00000259883; ENSP00000259883; ENSG00000137338.
GeneIDi84547.
KEGGihsa:84547.
UCSCiuc003nkz.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D88259 mRNA. Translation: BAB46919.1.
AK223446 mRNA. Translation: BAD97166.1.
AL021997 Genomic DNA. Translation: CAD21704.2.
BC069033 mRNA. Translation: AAH69033.1. Different termination.
BC128585 mRNA. Translation: AAI28586.1.
CCDSiCCDS4648.1.
RefSeqiNP_001171672.1. NM_001184743.1.
NP_115896.1. NM_032507.3.
XP_016866850.1. XM_017011361.1.
UniGeneiHs.144527.

3D structure databases

ProteinModelPortaliQ96JS3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124132. 24 interactors.
IntActiQ96JS3. 11 interactors.
STRINGi9606.ENSP00000259883.

PTM databases

iPTMnetiQ96JS3.
PhosphoSitePlusiQ96JS3.

Polymorphism and mutation databases

BioMutaiPGBD1.
DMDMi74751967.

Proteomic databases

EPDiQ96JS3.
MaxQBiQ96JS3.
PaxDbiQ96JS3.
PeptideAtlasiQ96JS3.
PRIDEiQ96JS3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000259883; ENSP00000259883; ENSG00000137338.
GeneIDi84547.
KEGGihsa:84547.
UCSCiuc003nkz.4. human.

Organism-specific databases

CTDi84547.
DisGeNETi84547.
GeneCardsiPGBD1.
HGNCiHGNC:19398. PGBD1.
HPAiHPA007267.
neXtProtiNX_Q96JS3.
OpenTargetsiENSG00000137338.
PharmGKBiPA134919893.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IHMN. Eukaryota.
ENOG410ZDPG. LUCA.
GeneTreeiENSGT00530000063278.
HOGENOMiHOG000115518.
HOVERGENiHBG099853.
InParanoidiQ96JS3.
OMAiHRACNPG.
OrthoDBiEOG091G05IL.
PhylomeDBiQ96JS3.
TreeFamiTF328011.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000137338-MONOMER.

Miscellaneous databases

GenomeRNAii84547.
PROiQ96JS3.

Gene expression databases

BgeeiENSG00000137338.
CleanExiHS_PGBD1.
GenevisibleiQ96JS3. HS.

Family and domain databases

InterProiIPR029526. PGBD.
IPR008916. Retrov_capsid_C.
IPR003309. SCAN_dom.
IPR001190. SRCR.
[Graphical view]
PfamiPF13843. DDE_Tnp_1_7. 1 hit.
PF02023. SCAN. 1 hit.
[Graphical view]
SMARTiSM00431. SCAN. 1 hit.
[Graphical view]
SUPFAMiSSF47353. SSF47353. 1 hit.
PROSITEiPS50804. SCAN_BOX. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPGBD1_HUMAN
AccessioniPrimary (citable) accession number: Q96JS3
Secondary accession number(s): Q53F43, Q6NTF5, Q8WWS4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: December 1, 2001
Last modified: November 30, 2016
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.