Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Membrane-spanning 4-domains subfamily A member 4A

Gene

MS4A4A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in signal transduction as a component of a multimeric receptor complex.

Keywordsi

Molecular functionReceptor

Names & Taxonomyi

Protein namesi
Recommended name:
Membrane-spanning 4-domains subfamily A member 4A
Alternative name(s):
CD20 antigen-like 1
Four-span transmembrane protein 1
Gene namesi
Name:MS4A4A
Synonyms:4SPAN1, CD20L1, MS4A4
ORF Names:HDCME31P
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000110079.16
HGNCiHGNC:13371 MS4A4A
MIMi606547 gene
neXtProtiNX_Q96JQ5

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 64CytoplasmicSequence analysisAdd BLAST64
Transmembranei65 – 85HelicalSequence analysisAdd BLAST21
Topological domaini86 – 98ExtracellularSequence analysisAdd BLAST13
Transmembranei99 – 119HelicalSequence analysisAdd BLAST21
Topological domaini120 – 137CytoplasmicSequence analysisAdd BLAST18
Transmembranei138 – 158HelicalSequence analysisAdd BLAST21
Topological domaini159 – 179ExtracellularSequence analysisAdd BLAST21
Transmembranei180 – 200HelicalSequence analysisAdd BLAST21
Topological domaini201 – 239CytoplasmicSequence analysisAdd BLAST39

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi51338
OpenTargetsiENSG00000110079
PharmGKBiPA31113

Polymorphism and mutation databases

BioMutaiMS4A4A
DMDMi30580442

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001586341 – 239Membrane-spanning 4-domains subfamily A member 4AAdd BLAST239

Proteomic databases

PaxDbiQ96JQ5
PeptideAtlasiQ96JQ5
PRIDEiQ96JQ5
ProteomicsDBi77005
77006 [Q96JQ5-2]

Expressioni

Tissue specificityi

Variable expression in multiple hemopoietic cell lines.

Gene expression databases

BgeeiENSG00000110079
CleanExiHS_MS4A4A
ExpressionAtlasiQ96JQ5 baseline and differential
GenevisibleiQ96JQ5 HS

Organism-specific databases

HPAiHPA029323

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

IntActiQ96JQ5, 9 interactors
STRINGi9606.ENSP00000338648

Structurei

3D structure databases

ProteinModelPortaliQ96JQ5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MS4A family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J084 Eukaryota
ENOG4112CBR LUCA
GeneTreeiENSGT00730000110654
HOGENOMiHOG000113440
HOVERGENiHBG054370
InParanoidiQ96JQ5
KOiK22190
OMAiMGITMMC
OrthoDBiEOG091G0IBB
PhylomeDBiQ96JQ5
TreeFamiTF335157

Family and domain databases

InterProiView protein in InterPro
IPR007237 CD20-like
IPR030417 MS4A
IPR030425 MS4A_4A/4E
PANTHERiPTHR23320 PTHR23320, 1 hit
PTHR23320:SF59 PTHR23320:SF59, 1 hit
PfamiView protein in Pfam
PF04103 CD20, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96JQ5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MHQTYSRHCR PEESTFSAAM TTMQGMEQAM PGAGPGVPQL GNMAVIHSHL
60 70 80 90 100
WKGLQEKFLK GEPKVLGVVQ ILTALMSLSM GITMMCMASN TYGSNPISVY
110 120 130 140 150
IGYTIWGSVM FIISGSLSIA AGIRTTKGLV RGSLGMNITS SVLAASGILI
160 170 180 190 200
NTFSLAFYSF HHPYCNYYGN SNNCHGTMSI LMGLDGMVLL LSVLEFCIAV
210 220 230
SLSAFGCKVL CCTPGGVVLI LPSHSHMAET ASPTPLNEV
Length:239
Mass (Da):25,441
Last modified:December 1, 2001 - v1
Checksum:iF0617D94669CB447
GO
Isoform 2 (identifier: Q96JQ5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     130-182: Missing.

Show »
Length:186
Mass (Da):19,682
Checksum:i14A89883D4417D17
GO

Sequence cautioni

The sequence AAF65507 differs from that shown. Reason: Frameshift at position 33.Curated
The sequence AAK37594 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAL08486 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAL56220 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB18738 differs from that shown. Reason: Frameshift at position 34.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti26M → I (PubMed:11245982).Curated1
Sequence conflicti100Y → H in AAF65507 (Ref. 5) Curated1
Sequence conflicti200V → C in AAL56220 (Ref. 4) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05351752K → E. Corresponds to variant dbSNP:rs10750931Ensembl.1
Natural variantiVAR_024540178M → V. Corresponds to variant dbSNP:rs6591561Ensembl.1
Natural variantiVAR_062123191L → I. Corresponds to variant dbSNP:rs4644658Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_007380130 – 182Missing in isoform 2. 1 PublicationAdd BLAST53

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB022821 mRNA Translation: BAB61018.1
AB013102 mRNA Translation: BAB18738.1 Frameshift.
AF237912 mRNA Translation: AAK37594.1 Different initiation.
AF350500 mRNA Translation: AAL56220.1 Different initiation.
AF068288 mRNA Translation: AAF65507.1 Frameshift.
AF354928 mRNA Translation: AAL08486.1 Different initiation.
BC020648 mRNA Translation: AAH20648.1
CCDSiCCDS58135.1 [Q96JQ5-2]
CCDS7982.1 [Q96JQ5-1]
RefSeqiNP_001230195.1, NM_001243266.1 [Q96JQ5-2]
NP_076926.2, NM_024021.3
NP_683876.1, NM_148975.2 [Q96JQ5-1]
XP_016873398.1, XM_017017909.1
UniGeneiHs.325960

Genome annotation databases

EnsembliENST00000337908; ENSP00000338648; ENSG00000110079 [Q96JQ5-1]
ENST00000532114; ENSP00000434506; ENSG00000110079 [Q96JQ5-2]
GeneIDi51338
KEGGihsa:51338
UCSCiuc001noz.4 human [Q96JQ5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiM4A4A_HUMAN
AccessioniPrimary (citable) accession number: Q96JQ5
Secondary accession number(s): Q8TEZ6
, Q96PG7, Q9BY18, Q9H3V3, Q9P1S3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 9, 2003
Last sequence update: December 1, 2001
Last modified: June 20, 2018
This is version 128 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health