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Protein

Calmin

Gene

CLMN

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Actin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Calmin
Alternative name(s):
Calponin-like transmembrane domain protein
Gene namesi
Name:CLMN
Synonyms:KIAA1188
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

HGNCiHGNC:19972. CLMN.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei977 – 99721Helical; Anchor for type IV membrane proteinSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134945356.

Polymorphism and mutation databases

BioMutaiCLMN.
DMDMi32699597.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10021002CalminPRO_0000089854Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei301 – 3011PhosphoserineCombined sources
Modified residuei402 – 4021PhosphoserineCombined sources
Modified residuei619 – 6191PhosphoserineCombined sources
Modified residuei699 – 6991PhosphothreonineCombined sources
Modified residuei713 – 7131PhosphoserineCombined sources
Modified residuei769 – 7691PhosphoserineCombined sources
Modified residuei838 – 8381PhosphoserineCombined sources
Modified residuei841 – 8411PhosphoserineCombined sources
Modified residuei907 – 9071PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ96JQ2.
MaxQBiQ96JQ2.
PaxDbiQ96JQ2.
PeptideAtlasiQ96JQ2.
PRIDEiQ96JQ2.

PTM databases

iPTMnetiQ96JQ2.
PhosphoSiteiQ96JQ2.

Expressioni

Tissue specificityi

Widely expressed at intermediate level.1 Publication

Gene expression databases

BgeeiQ96JQ2.
CleanExiHS_CLMN.
ExpressionAtlasiQ96JQ2. baseline and differential.
GenevisibleiQ96JQ2. HS.

Organism-specific databases

HPAiHPA012634.

Interactioni

Protein-protein interaction databases

BioGridi122889. 2 interactions.
IntActiQ96JQ2. 1 interaction.
STRINGi9606.ENSP00000298912.

Structurei

3D structure databases

ProteinModelPortaliQ96JQ2.
SMRiQ96JQ2. Positions 29-292.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 288288Actin-bindingAdd
BLAST
Domaini1 – 139139CH 1PROSITE-ProRule annotationAdd
BLAST
Domaini187 – 288102CH 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 actin-binding domain.Curated
Contains 2 CH (calponin-homology) domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0516. Eukaryota.
COG5069. LUCA.
GeneTreeiENSGT00760000118813.
HOVERGENiHBG039395.
InParanoidiQ96JQ2.
OMAiKRKHVDH.
OrthoDBiEOG7C5M8N.
PhylomeDBiQ96JQ2.
TreeFamiTF317709.

Family and domain databases

Gene3Di1.10.418.10. 2 hits.
InterProiIPR001589. Actinin_actin-bd_CS.
IPR001715. CH-domain.
[Graphical view]
PfamiPF00307. CH. 2 hits.
[Graphical view]
SMARTiSM00033. CH. 2 hits.
[Graphical view]
SUPFAMiSSF47576. SSF47576. 2 hits.
PROSITEiPS00019. ACTININ_1. 1 hit.
PS00020. ACTININ_2. 1 hit.
PS50021. CH. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96JQ2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAHEWDWFQ REELIGQISD IRVQNLQVER ENVQKRTFTR WINLHLEKCN
60 70 80 90 100
PPLEVKDLFV DIQDGKILMA LLEVLSGRNL LHEYKSSSHR IFRLNNIAKA
110 120 130 140 150
LKFLEDSNVK LVSIDAAEIA DGNPSLVLGL IWNIILFFQI KELTGNLSRN
160 170 180 190 200
SPSSSLSPGS GGTDSDSSFP PTPTAERSVA ISVKDQRKAI KALLAWVQRK
210 220 230 240 250
TRKYGVAVQD FAGSWRSGLA FLAVIKAIDP SLVDMKQALE NSTRENLEKA
260 270 280 290 300
FSIAQDALHI PRLLEPEDIM VDTPDEQSIM TYVAQFLERF PELEAEDIFD
310 320 330 340 350
SDKEVPIEST FVRIKETPSE QESKVFVLTE NGERTYTVNH ETSHPPPSKV
360 370 380 390 400
FVCDKPESMK EFRLDGVSSH ALSDSSTEFM HQIIDQVLQG GPGKTSDISE
410 420 430 440 450
PSPESSILSS RKENGRSNSL PIKKTVHFEA DTYKDPFCSK NLSLCFEGSP
460 470 480 490 500
RVAKESLRQD GHVLAVEVAE EKEQKQESSK IPESSSDKVA GDIFLVEGTN
510 520 530 540 550
NNSQSSSCNG ALESTARHDE ESHSLSPPGE NTVMADSFQI KVNLMTVEAL
560 570 580 590 600
EEGDYFEAIP LKASKFNSDL IDFASTSQAF NKVPSPHETK PDEDAEAFEN
610 620 630 640 650
HAEKLGKRSI KSAHKKKDSP EPQVKMDKHE PHQDSGEEAE GCPSAPEETP
660 670 680 690 700
VDKKPEVHEK AKRKSTRPHY EEEGEDDDLQ GVGEELSSSP PSSCVSLETL
710 720 730 740 750
GSHSEEGLDF KPSPPLSKVS VIPHDLFYFP HYEVPLAAVL EAYVEDPEDL
760 770 780 790 800
KNEEMDLEEP EGYMPDLDSR EEEADGSQSS SSSSVPGESL PSASDQVLYL
810 820 830 840 850
SRGGVGTTPA SEPAPLAPHE DHQQRETKEN DPMDSHQSQE SPNLENIANP
860 870 880 890 900
LEENVTKESI SSKKKEKRKH VDHVESSLFV APGSVQSSDD LEEDSSDYSI
910 920 930 940 950
PSRTSHSDSS IYLRRHTHRS SESDHFSYVQ LRNAADLDDR RNRILTRKAN
960 970 980 990 1000
SSGEAMSLGS HSPQSDSLTQ LVQQPDMMYF ILFLWLLVYC LLLFPQLDVS

RL
Length:1,002
Mass (Da):111,651
Last modified:December 1, 2001 - v1
Checksum:iD935F1744D76F0C4
GO

Sequence cautioni

The sequence BAB13999.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence BAB14036.1 differs from that shown.Chimeric cDNA.Curated
The sequence BAB14036.1 differs from that shown. Reason: Frameshift at position 493. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti661 – 6611A → V in BAB13999 (PubMed:14702039).Curated
Sequence conflicti866 – 8683EKR → KKK in BAB15087 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti963 – 9631P → L.
Corresponds to variant rs10149705 [ dbSNP | Ensembl ].
VAR_050866

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB047979 mRNA. Translation: BAB59010.1.
AK022279 mRNA. Translation: BAB13999.1. Different initiation.
AK022445 mRNA. Translation: BAB14036.1. Sequence problems.
AK025226 mRNA. Translation: BAB15087.1.
CH471061 Genomic DNA. Translation: EAW81598.1.
AK314315 mRNA. Translation: BAG36964.1.
AL117187 Genomic DNA. No translation available.
AL117526 mRNA. Translation: CAB55978.1.
AB033014 mRNA. Translation: BAA86502.1.
CCDSiCCDS9933.1.
PIRiT17288.
RefSeqiNP_079010.2. NM_024734.3.
UniGeneiHs.301478.

Genome annotation databases

EnsembliENST00000298912; ENSP00000298912; ENSG00000165959.
GeneIDi79789.
KEGGihsa:79789.
UCSCiuc001yef.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB047979 mRNA. Translation: BAB59010.1.
AK022279 mRNA. Translation: BAB13999.1. Different initiation.
AK022445 mRNA. Translation: BAB14036.1. Sequence problems.
AK025226 mRNA. Translation: BAB15087.1.
CH471061 Genomic DNA. Translation: EAW81598.1.
AK314315 mRNA. Translation: BAG36964.1.
AL117187 Genomic DNA. No translation available.
AL117526 mRNA. Translation: CAB55978.1.
AB033014 mRNA. Translation: BAA86502.1.
CCDSiCCDS9933.1.
PIRiT17288.
RefSeqiNP_079010.2. NM_024734.3.
UniGeneiHs.301478.

3D structure databases

ProteinModelPortaliQ96JQ2.
SMRiQ96JQ2. Positions 29-292.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122889. 2 interactions.
IntActiQ96JQ2. 1 interaction.
STRINGi9606.ENSP00000298912.

PTM databases

iPTMnetiQ96JQ2.
PhosphoSiteiQ96JQ2.

Polymorphism and mutation databases

BioMutaiCLMN.
DMDMi32699597.

Proteomic databases

EPDiQ96JQ2.
MaxQBiQ96JQ2.
PaxDbiQ96JQ2.
PeptideAtlasiQ96JQ2.
PRIDEiQ96JQ2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000298912; ENSP00000298912; ENSG00000165959.
GeneIDi79789.
KEGGihsa:79789.
UCSCiuc001yef.3. human.

Organism-specific databases

CTDi79789.
GeneCardsiCLMN.
HGNCiHGNC:19972. CLMN.
HPAiHPA012634.
MIMi611121. gene.
neXtProtiNX_Q96JQ2.
PharmGKBiPA134945356.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0516. Eukaryota.
COG5069. LUCA.
GeneTreeiENSGT00760000118813.
HOVERGENiHBG039395.
InParanoidiQ96JQ2.
OMAiKRKHVDH.
OrthoDBiEOG7C5M8N.
PhylomeDBiQ96JQ2.
TreeFamiTF317709.

Miscellaneous databases

ChiTaRSiCLMN. human.
GenomeRNAii79789.
PROiQ96JQ2.
SOURCEiSearch...

Gene expression databases

BgeeiQ96JQ2.
CleanExiHS_CLMN.
ExpressionAtlasiQ96JQ2. baseline and differential.
GenevisibleiQ96JQ2. HS.

Family and domain databases

Gene3Di1.10.418.10. 2 hits.
InterProiIPR001589. Actinin_actin-bd_CS.
IPR001715. CH-domain.
[Graphical view]
PfamiPF00307. CH. 2 hits.
[Graphical view]
SMARTiSM00033. CH. 2 hits.
[Graphical view]
SUPFAMiSSF47576. SSF47576. 2 hits.
PROSITEiPS00019. ACTININ_1. 1 hit.
PS00020. ACTININ_2. 1 hit.
PS50021. CH. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Calmin, a protein with calponin homology and transmembrane domains expressed in maturing spermatogenic cells."
    Ishisaki Z., Takaishi M., Furuta I., Huh N.-H.
    Genomics 74:172-179(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Placenta.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Colon, Mammary gland and Testis.
  3. "The DNA sequence and analysis of human chromosome 14."
    Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H.
    , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
    Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 12-865.
    Tissue: Testis.
  6. "Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain."
    Hirosawa M., Nagase T., Ishikawa K., Kikuno R., Nomura N., Ohara O.
    DNA Res. 6:329-336(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 524-862, TISSUE SPECIFICITY.
    Tissue: Brain.
  7. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-402, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  8. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  9. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-301; SER-619; THR-699; SER-713; SER-769; SER-838 AND SER-841, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiCLMN_HUMAN
AccessioniPrimary (citable) accession number: Q96JQ2
Secondary accession number(s): B2RAR7
, Q9H713, Q9HA23, Q9HA57, Q9UFP4, Q9ULN2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2003
Last sequence update: December 1, 2001
Last modified: July 6, 2016
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.