Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Calmin

Gene

CLMN

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Calmin
Alternative name(s):
Calponin-like transmembrane domain protein
Gene namesi
Name:CLMN
Synonyms:KIAA1188
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

EuPathDBiHostDB:ENSG00000165959.11
HGNCiHGNC:19972 CLMN
MIMi611121 gene
neXtProtiNX_Q96JQ2

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei977 – 997Helical; Anchor for type IV membrane proteinSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi79789
OpenTargetsiENSG00000165959
PharmGKBiPA134945356

Polymorphism and mutation databases

BioMutaiCLMN
DMDMi32699597

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000898541 – 1002CalminAdd BLAST1002

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei301PhosphoserineCombined sources1
Modified residuei402PhosphoserineCombined sources1
Modified residuei619PhosphoserineCombined sources1
Modified residuei699PhosphothreonineCombined sources1
Modified residuei713PhosphoserineCombined sources1
Modified residuei769PhosphoserineCombined sources1
Modified residuei838PhosphoserineCombined sources1
Modified residuei841PhosphoserineCombined sources1
Modified residuei907PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ96JQ2
MaxQBiQ96JQ2
PaxDbiQ96JQ2
PeptideAtlasiQ96JQ2
PRIDEiQ96JQ2

PTM databases

iPTMnetiQ96JQ2
PhosphoSitePlusiQ96JQ2

Expressioni

Tissue specificityi

Widely expressed at intermediate level.1 Publication

Gene expression databases

BgeeiENSG00000165959
CleanExiHS_CLMN
ExpressionAtlasiQ96JQ2 baseline and differential
GenevisibleiQ96JQ2 HS

Organism-specific databases

HPAiHPA012634

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi122889, 12 interactors
IntActiQ96JQ2, 3 interactors
STRINGi9606.ENSP00000298912

Structurei

3D structure databases

ProteinModelPortaliQ96JQ2
SMRiQ96JQ2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini32 – 139Calponin-homology (CH) 1PROSITE-ProRule annotationAdd BLAST108
Domaini187 – 291Calponin-homology (CH) 2PROSITE-ProRule annotationAdd BLAST105

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 288Actin-bindingAdd BLAST288

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0516 Eukaryota
COG5069 LUCA
GeneTreeiENSGT00900000140842
HOVERGENiHBG039395
InParanoidiQ96JQ2
OMAiKRKHVDH
OrthoDBiEOG091G0007
PhylomeDBiQ96JQ2
TreeFamiTF317709

Family and domain databases

CDDicd00014 CH, 2 hits
Gene3Di1.10.418.10, 2 hits
InterProiView protein in InterPro
IPR001589 Actinin_actin-bd_CS
IPR001715 CH-domain
IPR036872 CH_dom_sf
PfamiView protein in Pfam
PF00307 CH, 2 hits
SMARTiView protein in SMART
SM00033 CH, 2 hits
SUPFAMiSSF47576 SSF47576, 2 hits
PROSITEiView protein in PROSITE
PS00019 ACTININ_1, 1 hit
PS00020 ACTININ_2, 1 hit
PS50021 CH, 2 hits

Sequencei

Sequence statusi: Complete.

Q96JQ2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAHEWDWFQ REELIGQISD IRVQNLQVER ENVQKRTFTR WINLHLEKCN
60 70 80 90 100
PPLEVKDLFV DIQDGKILMA LLEVLSGRNL LHEYKSSSHR IFRLNNIAKA
110 120 130 140 150
LKFLEDSNVK LVSIDAAEIA DGNPSLVLGL IWNIILFFQI KELTGNLSRN
160 170 180 190 200
SPSSSLSPGS GGTDSDSSFP PTPTAERSVA ISVKDQRKAI KALLAWVQRK
210 220 230 240 250
TRKYGVAVQD FAGSWRSGLA FLAVIKAIDP SLVDMKQALE NSTRENLEKA
260 270 280 290 300
FSIAQDALHI PRLLEPEDIM VDTPDEQSIM TYVAQFLERF PELEAEDIFD
310 320 330 340 350
SDKEVPIEST FVRIKETPSE QESKVFVLTE NGERTYTVNH ETSHPPPSKV
360 370 380 390 400
FVCDKPESMK EFRLDGVSSH ALSDSSTEFM HQIIDQVLQG GPGKTSDISE
410 420 430 440 450
PSPESSILSS RKENGRSNSL PIKKTVHFEA DTYKDPFCSK NLSLCFEGSP
460 470 480 490 500
RVAKESLRQD GHVLAVEVAE EKEQKQESSK IPESSSDKVA GDIFLVEGTN
510 520 530 540 550
NNSQSSSCNG ALESTARHDE ESHSLSPPGE NTVMADSFQI KVNLMTVEAL
560 570 580 590 600
EEGDYFEAIP LKASKFNSDL IDFASTSQAF NKVPSPHETK PDEDAEAFEN
610 620 630 640 650
HAEKLGKRSI KSAHKKKDSP EPQVKMDKHE PHQDSGEEAE GCPSAPEETP
660 670 680 690 700
VDKKPEVHEK AKRKSTRPHY EEEGEDDDLQ GVGEELSSSP PSSCVSLETL
710 720 730 740 750
GSHSEEGLDF KPSPPLSKVS VIPHDLFYFP HYEVPLAAVL EAYVEDPEDL
760 770 780 790 800
KNEEMDLEEP EGYMPDLDSR EEEADGSQSS SSSSVPGESL PSASDQVLYL
810 820 830 840 850
SRGGVGTTPA SEPAPLAPHE DHQQRETKEN DPMDSHQSQE SPNLENIANP
860 870 880 890 900
LEENVTKESI SSKKKEKRKH VDHVESSLFV APGSVQSSDD LEEDSSDYSI
910 920 930 940 950
PSRTSHSDSS IYLRRHTHRS SESDHFSYVQ LRNAADLDDR RNRILTRKAN
960 970 980 990 1000
SSGEAMSLGS HSPQSDSLTQ LVQQPDMMYF ILFLWLLVYC LLLFPQLDVS

RL
Length:1,002
Mass (Da):111,651
Last modified:December 1, 2001 - v1
Checksum:iD935F1744D76F0C4
GO

Sequence cautioni

The sequence BAB13999 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB14036 differs from that shown. Chimeric cDNA.Curated
The sequence BAB14036 differs from that shown. Reason: Frameshift at position 493.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti661A → V in BAB13999 (PubMed:14702039).Curated1
Sequence conflicti866 – 868EKR → KKK in BAB15087 (PubMed:14702039).Curated3

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_050866963P → L. Corresponds to variant dbSNP:rs10149705Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB047979 mRNA Translation: BAB59010.1
AK022279 mRNA Translation: BAB13999.1 Different initiation.
AK022445 mRNA Translation: BAB14036.1 Sequence problems.
AK025226 mRNA Translation: BAB15087.1
CH471061 Genomic DNA Translation: EAW81598.1
AK314315 mRNA Translation: BAG36964.1
AL117187 Genomic DNA No translation available.
AL117526 mRNA Translation: CAB55978.1
AB033014 mRNA Translation: BAA86502.1
CCDSiCCDS9933.1
PIRiT17288
RefSeqiNP_079010.2, NM_024734.3
UniGeneiHs.301478

Genome annotation databases

EnsembliENST00000298912; ENSP00000298912; ENSG00000165959
GeneIDi79789
KEGGihsa:79789
UCSCiuc001yef.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiCLMN_HUMAN
AccessioniPrimary (citable) accession number: Q96JQ2
Secondary accession number(s): B2RAR7
, Q9H713, Q9HA23, Q9HA57, Q9UFP4, Q9ULN2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2003
Last sequence update: December 1, 2001
Last modified: May 23, 2018
This is version 126 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health