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Q96JQ0 (PCD16_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 109. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protocadherin-16
Alternative name(s):
Cadherin-19
Cadherin-25
Fibroblast cadherin-1
Protein dachsous homolog 1
Gene names
Name:DCHS1
Synonyms:CDH19, CDH25, FIB1, KIAA1773, PCDH16
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length3298 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Calcium-dependent cell-adhesion protein Potential.

Subcellular location

Cell membrane; Single-pass type I membrane protein By similarity.

Tissue specificity

Fibroblast specific.

Sequence similarities

Contains 27 cadherin domains.

Sequence caution

The sequence BAB61903.2 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Biological processCell adhesion
   Cellular componentCell membrane
Membrane
   Coding sequence diversityPolymorphism
   DomainRepeat
Signal
Transmembrane
Transmembrane helix
   LigandCalcium
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcalcium-dependent cell-cell adhesion

Non-traceable author statement Ref.3. Source: UniProtKB

homophilic cell adhesion

Inferred from electronic annotation. Source: InterPro

   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

membrane

Non-traceable author statement Ref.3. Source: UniProtKB

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functioncalcium ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 4242 Potential
Chain43 – 32983256Protocadherin-16
PRO_0000004000

Regions

Topological domain43 – 29402898Extracellular Potential
Transmembrane2941 – 296121Helical; Potential
Topological domain2962 – 3298337Cytoplasmic Potential
Domain43 – 143101Cadherin 1
Domain144 – 255112Cadherin 2
Domain256 – 362107Cadherin 3
Domain367 – 472106Cadherin 4
Domain474 – 578105Cadherin 5
Domain579 – 685107Cadherin 6
Domain686 – 790105Cadherin 7
Domain791 – 894104Cadherin 8
Domain895 – 1000106Cadherin 9
Domain1001 – 1111111Cadherin 10
Domain1112 – 1211100Cadherin 11
Domain1218 – 1324107Cadherin 12
Domain1333 – 1436104Cadherin 13
Domain1437 – 1546110Cadherin 14
Domain1547 – 1649103Cadherin 15
Domain1650 – 1751102Cadherin 16
Domain1752 – 1855104Cadherin 17
Domain1856 – 1960105Cadherin 18
Domain1965 – 2068104Cadherin 19
Domain2069 – 2171103Cadherin 20
Domain2172 – 2277106Cadherin 21
Domain2278 – 237699Cadherin 22
Domain2377 – 2482106Cadherin 23
Domain2483 – 2602120Cadherin 24
Domain2603 – 2706104Cadherin 25
Domain2707 – 2813107Cadherin 26
Domain2814 – 2933120Cadherin 27

Amino acid modifications

Glycosylation2171N-linked (GlcNAc...) Potential
Glycosylation2561N-linked (GlcNAc...) Potential
Glycosylation4021N-linked (GlcNAc...) Potential
Glycosylation5841N-linked (GlcNAc...) Potential
Glycosylation12491N-linked (GlcNAc...) Potential
Glycosylation15211N-linked (GlcNAc...) Potential
Glycosylation17181N-linked (GlcNAc...) Potential
Glycosylation19961N-linked (GlcNAc...) Potential
Glycosylation23611N-linked (GlcNAc...) Potential
Glycosylation24281N-linked (GlcNAc...) Potential
Glycosylation25691N-linked (GlcNAc...) Potential
Glycosylation27611N-linked (GlcNAc...) Potential
Glycosylation27921N-linked (GlcNAc...) Potential
Glycosylation28621N-linked (GlcNAc...) Potential

Natural variations

Natural variant15831R → W in a colorectal cancer sample; somatic mutation. Ref.4
VAR_036110
Natural variant19491T → M.
Corresponds to variant rs4758443 [ dbSNP | Ensembl ].
VAR_048577
Natural variant21721L → Q.
Corresponds to variant rs56920123 [ dbSNP | Ensembl ].
VAR_061074
Natural variant23311V → I.
Corresponds to variant rs7924553 [ dbSNP | Ensembl ].
VAR_048578
Natural variant23591R → C.
Corresponds to variant rs2659875 [ dbSNP | Ensembl ].
VAR_048579

Sequences

Sequence LengthMass (Da)Tools
Q96JQ0 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: 6EE8D28BEF0795DB

FASTA3,298346,181
        10         20         30         40         50         60 
MQKELGIVPS CPGMKSPRPH LLLPLLLLLL LLLGAGVPGA WGQAGSLDLQ IDEEQPAGTL 

        70         80         90        100        110        120 
IGDISAGLPA GTAAPLMYFI SAQEGSGVGT DLAIDEHSGV VRTARVLDRE QRDRYRFTAV 

       130        140        150        160        170        180 
TPDGATVEVT VRVADINDHA PAFPQARAAL QVPEHTAFGT RYPLEPARDA DAGRLGTQGY 

       190        200        210        220        230        240 
ALSGDGAGET FRLETRPGPD GTPVPELVVT GELDRENRSH YMLQLEAYDG GSPPRRAQAL 

       250        260        270        280        290        300 
LDVTLLDIND HAPAFNQSRY HAVVSESLAP GSPVLQVFAS DADAGVNGAV TYEINRRQSE 

       310        320        330        340        350        360 
GDGPFSIDAH TGLLQLERPL DFEQRRVHEL VVQARDGGAH PELGSAFVTV HVRDANDNQP 

       370        380        390        400        410        420 
SMTVIFLSAD GSPQVSEAAP PGQLVARISV SDPDDGDFAH VNVSLEGGEG HFALSTQDSV 

       430        440        450        460        470        480 
IYLVCVARRL DREERDAYNL RVTATDSGSP PLRAEAAFVL HVTDVNDNAP AFDRQLYRPE 

       490        500        510        520        530        540 
PLPEVALPGS FVVRVTARDP DQGTNGQVTY SLAPGAHTHW FSIDPTSGII TTAASLDYEL 

       550        560        570        580        590        600 
EPQPQLIVVA TDGGLPPLAS SATVSVALQD VNDNEPQFQR TFYNASLPEG TQPGTCFLQV 

       610        620        630        640        650        660 
TATDADSGPF GLLSYSLGAG LGSSGSPPFR IDAHSGDVCT TRTLDRDQGP SSFDFTVTAV 

       670        680        690        700        710        720 
DGGGLKSMVY VKVFLSDEND NPPQFYPREY AASISAQSPP GTAVLRLRAH DPDQGSHGRL 

       730        740        750        760        770        780 
SYHILAGNSP PLFTLDEQSG LLTVAWPLAR RANSVVQLEI GAEDGGGLQA EPSARVDISI 

       790        800        810        820        830        840 
VPGTPTPPIF EQLQYVFSVP EDVAPGTSVG IVQAHNPPGR LAPVTLSLSG GDPRGLFSLD 

       850        860        870        880        890        900 
AVSGLLQTLR PLDRELLGPV LELEVRAGSG VPPAFAVARV RVLLDDVNDN SPAFPAPEDT 

       910        920        930        940        950        960 
VLLPPNTAPG TPIYTLRALD PDSGVNSRVT FTLLAGGGGA FTVDPTTGHV RLMRPLGPSG 

       970        980        990       1000       1010       1020 
GPAHELELEA RDGGSPPRTS HFRLRVVVQD VGTRGLAPRF NSPTYRVDLP SGTTAGTQVL 

      1030       1040       1050       1060       1070       1080 
QVQAQAPDGG PITYHLAAEG ASSPFGLEPQ SGWLWVRAAL DREAQELYIL KVMAVSGSKA 

      1090       1100       1110       1120       1130       1140 
ELGQQTGTAT VRVSILNQNE HSPRLSEDPT FLAVAENQPP GTSVGRVFAT DRDSGPNGRL 

      1150       1160       1170       1180       1190       1200 
TYSLQQLSED SKAFRIHPQT GEVTTLQTLD REQQSSYQLL VQVQDGGSPP RSTTGTVHVA 

      1210       1220       1230       1240       1250       1260 
VLDLNDNSPT FLQASGAAGG GLPIQVPDRV PPGTLVTTLQ AKDPDEGENG TILYTLTGPG 

      1270       1280       1290       1300       1310       1320 
SELFSLHPHS GELLTAAPLI RAERPHYVLT LSAHDQGSPP RSASLQLLVQ VLPSARLAEP 

      1330       1340       1350       1360       1370       1380 
PPDLAERDPA APVPVVLTVT AAEGLRPGSL LGSVAAPEPA GVGALTYTLV GGADPEGTFA 

      1390       1400       1410       1420       1430       1440 
LDAASGRLYL ARPLDFEAGP PWRALTVRAE GPGGAGARLL RVQVQVQDEN EHAPAFARDP 

      1450       1460       1470       1480       1490       1500 
LALALPENPE PGAALYTFRA SDADGPGPNS DVRYRLLRQE PPVPALRLDA RTGALSAPRG 

      1510       1520       1530       1540       1550       1560 
LDRETTPALL LLVEATDRPA NASRRRAARV SARVFVTDEN DNAPVFASPS RVRLPEDQPP 

      1570       1580       1590       1600       1610       1620 
GPAALHVVAR DPDLGEAARV SYRLASGGDG HFRLHSSTGA LSVVRPLDRE QRAEHVLTVV 

      1630       1640       1650       1660       1670       1680 
ASDHGSPPRS ATQVLTVSVA DVNDEAPTFQ QQEYSVLLRE NNPPGTSLLT LRATDPDVGA 

      1690       1700       1710       1720       1730       1740 
NGQVTYGGVS SESFSLDPDT GVLTTLRALD REEQEEINLT VYAQDRGSPP QLTHVTVRVA 

      1750       1760       1770       1780       1790       1800 
VEDENDHAPT FGSAHLSLEV PEGQDPQTLT MLRASDPDVG ANGQLQYRIL DGDPSGAFVL 

      1810       1820       1830       1840       1850       1860 
DLASGEFGTM RPLDREVEPA FQLRIEARDG GQPALSATLL LTVTVLDAND HAPAFPVPAY 

      1870       1880       1890       1900       1910       1920 
SVEVPEDVPA GTLLLQLQAH DPDAGANGHV TYYLGAGTAG AFLLEPSSGE LRTAAALDRE 

      1930       1940       1950       1960       1970       1980 
QCPSYTFSVS AVDGAAAGPL STTVSVTITV RDVNDHAPTF PTSPLRLRLP RPGPSFSTPT 

      1990       2000       2010       2020       2030       2040 
LALATLRAED RDAGANASIL YRLAGTPPPG TTVDSYTGEI RVARSPVALG PRDRVLFIVA 

      2050       2060       2070       2080       2090       2100 
TDLGRPARSA TGVIIVGLQG EAERGPRFPR ASSEATIREN APPGTPIVSP RAVHAGGTNG 

      2110       2120       2130       2140       2150       2160 
PITYSILSGN EKGTFSIQPS TGAITVRSAE GLDFEVSPRL RLVLQAESGG AFAFTVLTLT 

      2170       2180       2190       2200       2210       2220 
LQDANDNAPR FLRPHYVAFL PESRPLEGPL LQVEADDLDQ GSGGQISYSL AASQPARGLF 

      2230       2240       2250       2260       2270       2280 
HVDPTTGTIT TTAILDREIW AETRLVLMAT DRGSPALVGS ATLTVMVIDT NDNRPTIPQP 

      2290       2300       2310       2320       2330       2340 
WELRVSEDAL LGSEIAQVTG NDVDSGPVLW YVLSPSGPQD PFSVGRYGGR VSLTGPLDFE 

      2350       2360       2370       2380       2390       2400 
QCDRYQLQLL AHDGPHEGRA NLTVLVEDVN DNAPAFSQSL YQVMLLEHTP PGSAILSVSA 

      2410       2420       2430       2440       2450       2460 
TDRDSGANGH ISYHLASPAD GFSVDPNNGT LFTIVGTVAL GHDGSGAVDV VLEARDHGAP 

      2470       2480       2490       2500       2510       2520 
GRAARATVHV QLQDQNDHAP SFTLSHYRVA VTEDLPPGST LLTLEATDAD GSRSHAAVDY 

      2530       2540       2550       2560       2570       2580 
SIISGNWGRV FQLEPRLAEA GESAGPGPRA LGCLVLLEPL DFESLTQYNL TVAAADRGQP 

      2590       2600       2610       2620       2630       2640 
PQSSVVPVTV TVLDVNDNPP VFTRASYRVT VPEDTPVGAE LLHVEASDAD PGPHGLVRFT 

      2650       2660       2670       2680       2690       2700 
VSSGDPSGLF ELDESSGTLR LAHALDCETQ ARHQLVVQAA DPAGAHFALA PVTIEVQDVN 

      2710       2720       2730       2740       2750       2760 
DHGPAFPLNL LSTSVAENQP PGTLVTTLHA IDGDAGAFGR LRYSLLEAGP GPEGREAFAL 

      2770       2780       2790       2800       2810       2820 
NSSTGELRAR VPFDYEHTES FRLLVGAADA GNLSASVTVS VLVTGEDEYD PVFLAPAFHF 

      2830       2840       2850       2860       2870       2880 
QVPEGARRGH SLGHVQATDE DGGADGLVLY SLATSSPYFG INQTTGALYL RVDSRAPGSG 

      2890       2900       2910       2920       2930       2940 
TATSGGGGRT RREAPRELRL EVIARGPLPG SRSATVPVTV DITHTALGLA PDLNLLLVGA 

      2950       2960       2970       2980       2990       3000 
VAASLGVVVV LALAALVLGL VRARSRKAEA APGPMSQAAP LASDSLQKLG REPPSPPPSE 

      3010       3020       3030       3040       3050       3060 
HLYHQTLPSY GGPGAGGPYP RGGSLDPSHS SGRGSAEAAE DDEIRMINEF PRVASVASSL 

      3070       3080       3090       3100       3110       3120 
AARGPDSGIQ QDADGLSDTS CEPPAPDTWY KGRKAGLLLP GAGATLYREE GPPATATAFL 

      3130       3140       3150       3160       3170       3180 
GGCGLSPAPT GDYGFPADGK PCVAGALTAI VAGEEELRGS YNWDYLLSWC PQFQPLASVF 

      3190       3200       3210       3220       3230       3240 
TEIARLKDEA RPCPPAPRID PPPLITAVAH PGAKSVPPKP ANTAAARAIF PPASHRSPIS 

      3250       3260       3270       3280       3290 
HEGSLSSAAM SPSFSPSLSP LAARSPVVSP FGVAQGPSAS ALSAESGLEP PDDTELHI 

« Hide

References

« Hide 'large scale' references
[1]"Identification of three novel non-classical cadherin genes through comprehensive analysis of large cDNAs."
Nakajima D., Nakayama M., Kikuno R., Hirosawa M., Nagase T., Ohara O.
Brain Res. Mol. Brain Res. 94:85-95(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Brain.
[2]Nakajima D., Nakayama M., Kikuno R., Nagase T., Ohara O.
Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
Cited for: SEQUENCE REVISION.
[3]"Multiple cadherins are expressed in human fibroblasts."
Matsuyoshi N., Imamura S.
Biochem. Biophys. Res. Commun. 235:355-358(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 434-570.
[4]"The consensus coding sequences of human breast and colorectal cancers."
Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. expand/collapse author list , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E.
Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT [LARGE SCALE ANALYSIS] TRP-1583.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB053446 mRNA. Translation: BAB61903.2. Different initiation.
AB000895 mRNA. Translation: BAA21133.1.
PIRPC4297.
RefSeqNP_003728.1. NM_003737.3.
UniGeneHs.199850.

3D structure databases

ProteinModelPortalQ96JQ0.
SMRQ96JQ0. Positions 48-2925.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid114194. 2 interactions.
IntActQ96JQ0. 2 interactions.
STRING9606.ENSP00000299441.

PTM databases

PhosphoSiteQ96JQ0.

Polymorphism databases

DMDM20139065.

Proteomic databases

PaxDbQ96JQ0.
PRIDEQ96JQ0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000299441; ENSP00000299441; ENSG00000166341.
GeneID8642.
KEGGhsa:8642.
UCSCuc001mem.1. human.

Organism-specific databases

CTD8642.
GeneCardsGC11M006642.
HGNCHGNC:13681. DCHS1.
HPAHPA017970.
HPA050246.
MIM603057. gene.
neXtProtNX_Q96JQ0.
Orphanet314679. Cerebro-facio-articular syndrome.
PharmGKBPA33000.
HUGESearch...
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG12793.
HOGENOMHOG000115466.
HOVERGENHBG053522.
InParanoidQ96JQ0.
KOK16507.
OMALYQVMLL.
OrthoDBEOG75TM9Z.
PhylomeDBQ96JQ0.
TreeFamTF316403.

Gene expression databases

BgeeQ96JQ0.
CleanExHS_CDH19.
HS_DCHS1.
GenevestigatorQ96JQ0.

Family and domain databases

Gene3D2.60.40.60. 27 hits.
InterProIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
[Graphical view]
PfamPF00028. Cadherin. 23 hits.
[Graphical view]
PRINTSPR00205. CADHERIN.
SMARTSM00112. CA. 27 hits.
[Graphical view]
SUPFAMSSF49313. SSF49313. 27 hits.
PROSITEPS00232. CADHERIN_1. 18 hits.
PS50268. CADHERIN_2. 27 hits.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiDCHS1.
GenomeRNAi8642.
NextBio32399.
PROQ96JQ0.
SOURCESearch...

Entry information

Entry namePCD16_HUMAN
AccessionPrimary (citable) accession number: Q96JQ0
Secondary accession number(s): O15098
Entry history
Integrated into UniProtKB/Swiss-Prot: February 11, 2002
Last sequence update: December 1, 2001
Last modified: April 16, 2014
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM