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Q96JP5

- ZFP91_HUMAN

UniProt

Q96JP5 - ZFP91_HUMAN

Protein

E3 ubiquitin-protein ligase ZFP91

Gene

ZFP91

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 118 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    Atypical E3 ubiquitin-protein ligase that mediates 'Lys-63'-linked ubiquitination of MAP3K14/NIK, leading to stabilize and activate MAP3K14/NIK. It thereby acts as an activator of the non-canonical NF-kappa-B2/NFKB2 pathway. May also play an important role in cell proliferation and/or anti-apoptosis.2 Publications

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri311 – 33626C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri342 – 36625C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri372 – 39423C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri400 – 42223C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri430 – 45324C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. ligase activity Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW
    3. nucleic acid binding Source: InterPro
    4. ubiquitin-protein transferase activity Source: UniProtKB

    GO - Biological processi

    1. activation of NF-kappaB-inducing kinase activity Source: UniProtKB
    2. protein K63-linked ubiquitination Source: UniProtKB

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Ubl conjugation pathway

    Keywords - Ligandi

    Metal-binding, Zinc

    Enzyme and pathway databases

    UniPathwayiUPA00143.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    E3 ubiquitin-protein ligase ZFP91 (EC:6.3.2.-)
    Alternative name(s):
    Zinc finger protein 757
    Zinc finger protein 91 homolog
    Short name:
    Zfp-91
    Gene namesi
    Name:ZFP91
    Synonyms:ZNF757
    ORF Names:FKSG11
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:14983. ZFP91.

    Subcellular locationi

    Nucleus 1 Publication

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi344 – 3441C → A: Abolishes ubiquitination of MAP3K14/NIK; when associated with A-349. 1 Publication
    Mutagenesisi349 – 3491C → A: Abolishes ubiquitination of MAP3K14/NIK; when associated with A-344. 1 Publication

    Organism-specific databases

    PharmGKBiPA37955.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed1 Publication
    Chaini2 – 570569E3 ubiquitin-protein ligase ZFP91PRO_0000047312Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei103 – 1031PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ96JP5.
    PaxDbiQ96JP5.
    PRIDEiQ96JP5.

    PTM databases

    PhosphoSiteiQ96JP5.

    Expressioni

    Tissue specificityi

    Expressed ubiquitously, particularly at high level in testis. Isoform 2 is testis specific.

    Gene expression databases

    ArrayExpressiQ96JP5.
    BgeeiQ96JP5.
    CleanExiHS_ZFP91.
    GenevestigatoriQ96JP5.

    Organism-specific databases

    HPAiCAB025417.
    HPA024037.

    Interactioni

    Subunit structurei

    Interacts with MAP3K14/NIK.2 Publications

    Protein-protein interaction databases

    BioGridi123322. 10 interactions.
    IntActiQ96JP5. 3 interactions.
    STRINGi9606.ENSP00000339030.

    Structurei

    Secondary structure

    1
    570
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi381 – 3833
    Helixi384 – 3907
    Helixi391 – 3933
    Beta strandi395 – 3973
    Beta strandi408 – 4114
    Helixi412 – 42312
    Beta strandi426 – 4294
    Turni433 – 4353
    Helixi442 – 45211

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2M9ANMR-A370-456[»]
    ProteinModelPortaliQ96JP5.
    SMRiQ96JP5. Positions 313-456.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni338 – 36831Interaction with MAP3K14/NIKAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi21 – 6747Ala-richAdd
    BLAST
    Compositional biasi48 – 8134Arg-richAdd
    BLAST
    Compositional biasi197 – 28286Glu-richAdd
    BLAST

    Sequence similaritiesi

    Contains 5 C2H2-type zinc fingers.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri311 – 33626C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri342 – 36625C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri372 – 39423C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri400 – 42223C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri430 – 45324C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiNOG290299.
    HOGENOMiHOG000155779.
    HOVERGENiHBG055547.
    InParanoidiQ96JP5.
    OMAiGLVMNTE.
    OrthoDBiEOG7SV0TZ.
    PhylomeDBiQ96JP5.
    TreeFamiTF332664.

    Family and domain databases

    Gene3Di3.30.160.60. 3 hits.
    InterProiIPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view]
    PfamiPF00096. zf-C2H2. 1 hit.
    [Graphical view]
    SMARTiSM00355. ZnF_C2H2. 5 hits.
    [Graphical view]
    PROSITEiPS00028. ZINC_FINGER_C2H2_1. 5 hits.
    PS50157. ZINC_FINGER_C2H2_2. 4 hits.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q96JP5-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MPGETEEPRP PEQQDQEGGE AAKAAPEEPQ QRPPEAVAAA PAGTTSSRVL    50
    RGGRDRGRAA AAAAAAAVSR RRKAEYPRRR RSSPSARPPD VPGQQPQAAK 100
    SPSPVQGKKS PRLLCIEKVT TDKDPKEEKE EEDDSALPQE VSIAASRPSR 150
    GWRSSRTSVS RHRDTENTRS SRSKTGSLQL ICKSEPNTDQ LDYDVGEEHQ 200
    SPGGISSEEE EEEEEEMLIS EEEIPFKDDP RDETYKPHLE RETPKPRRKS 250
    GKVKEEKEKK EIKVEVEVEV KEEENEIRED EEPPRKRGRR RKDDKSPRLP 300
    KRRKKPPIQY VRCEMEGCGT VLAHPRYLQH HIKYQHLLKK KYVCPHPSCG 350
    RLFRLQKQLL RHAKHHTDQR DYICEYCARA FKSSHNLAVH RMIHTGEKPL 400
    QCEICGFTCR QKASLNWHMK KHDADSFYQF SCNICGKKFE KKDSVVAHKA 450
    KSHPEVLIAE ALAANAGALI TSTDILGTNP ESLTQPSDGQ GLPLLPEPLG 500
    NSTSGECLLL EAEGMSKSYC SGTERVSLMA DGKIFVGSGS SGGTEGLVMN 550
    SDILGATTEV LIEDSDSAGP 570
    Length:570
    Mass (Da):63,445
    Last modified:December 1, 2001 - v1
    Checksum:i476F4C21DD453522
    GO
    Isoform 2 (identifier: Q96JP5-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         526-529: VSLM → SIHR
         530-570: Missing.

    Show »
    Length:529
    Mass (Da):59,571
    Checksum:iD181F0420D5D004F
    GO

    Sequence cautioni

    The sequence AAL09963.1 differs from that shown. Reason: Frameshift at positions 72 and 80.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti74 – 741A → V in AAL09963. 1 PublicationCurated
    Sequence conflicti206 – 2061Missing in AAH51743. (PubMed:15489334)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti37 – 371V → I.1 Publication
    Corresponds to variant rs17854702 [ dbSNP | Ensembl ].
    VAR_032454
    Natural varianti207 – 2071S → G.1 Publication
    Corresponds to variant rs8373 [ dbSNP | Ensembl ].
    VAR_021889

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei526 – 5294VSLM → SIHR in isoform 2. 1 PublicationVSP_012686
    Alternative sequencei530 – 57041Missing in isoform 2. 1 PublicationVSP_012687Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB056107 mRNA. Translation: BAB63373.1.
    AB057443 mRNA. Translation: BAB63374.1.
    AP001350 Genomic DNA. No translation available.
    CH471076 Genomic DNA. Translation: EAW73811.1.
    BC051743 mRNA. Translation: AAH51743.1.
    AF310246 mRNA. Translation: AAL09963.1. Frameshift.
    CCDSiCCDS31553.1. [Q96JP5-1]
    RefSeqiNP_001183980.1. NM_001197051.1.
    NP_444251.1. NM_053023.4. [Q96JP5-1]
    UniGeneiHs.524920.

    Genome annotation databases

    EnsembliENST00000316059; ENSP00000339030; ENSG00000186660. [Q96JP5-1]
    GeneIDi80829.
    KEGGihsa:80829.
    UCSCiuc001nmx.4. human. [Q96JP5-1]

    Polymorphism databases

    DMDMi60416377.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB056107 mRNA. Translation: BAB63373.1 .
    AB057443 mRNA. Translation: BAB63374.1 .
    AP001350 Genomic DNA. No translation available.
    CH471076 Genomic DNA. Translation: EAW73811.1 .
    BC051743 mRNA. Translation: AAH51743.1 .
    AF310246 mRNA. Translation: AAL09963.1 . Frameshift.
    CCDSi CCDS31553.1. [Q96JP5-1 ]
    RefSeqi NP_001183980.1. NM_001197051.1.
    NP_444251.1. NM_053023.4. [Q96JP5-1 ]
    UniGenei Hs.524920.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2M9A NMR - A 370-456 [» ]
    ProteinModelPortali Q96JP5.
    SMRi Q96JP5. Positions 313-456.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 123322. 10 interactions.
    IntActi Q96JP5. 3 interactions.
    STRINGi 9606.ENSP00000339030.

    PTM databases

    PhosphoSitei Q96JP5.

    Polymorphism databases

    DMDMi 60416377.

    Proteomic databases

    MaxQBi Q96JP5.
    PaxDbi Q96JP5.
    PRIDEi Q96JP5.

    Protocols and materials databases

    DNASUi 80829.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000316059 ; ENSP00000339030 ; ENSG00000186660 . [Q96JP5-1 ]
    GeneIDi 80829.
    KEGGi hsa:80829.
    UCSCi uc001nmx.4. human. [Q96JP5-1 ]

    Organism-specific databases

    CTDi 80829.
    GeneCardsi GC11P058347.
    HGNCi HGNC:14983. ZFP91.
    HPAi CAB025417.
    HPA024037.
    neXtProti NX_Q96JP5.
    PharmGKBi PA37955.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG290299.
    HOGENOMi HOG000155779.
    HOVERGENi HBG055547.
    InParanoidi Q96JP5.
    OMAi GLVMNTE.
    OrthoDBi EOG7SV0TZ.
    PhylomeDBi Q96JP5.
    TreeFami TF332664.

    Enzyme and pathway databases

    UniPathwayi UPA00143 .

    Miscellaneous databases

    ChiTaRSi ZFP91. human.
    GeneWikii ZFP91.
    GenomeRNAii 80829.
    NextBioi 71236.
    PROi Q96JP5.

    Gene expression databases

    ArrayExpressi Q96JP5.
    Bgeei Q96JP5.
    CleanExi HS_ZFP91.
    Genevestigatori Q96JP5.

    Family and domain databases

    Gene3Di 3.30.160.60. 3 hits.
    InterProi IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view ]
    Pfami PF00096. zf-C2H2. 1 hit.
    [Graphical view ]
    SMARTi SM00355. ZnF_C2H2. 5 hits.
    [Graphical view ]
    PROSITEi PS00028. ZINC_FINGER_C2H2_1. 5 hits.
    PS50157. ZINC_FINGER_C2H2_2. 4 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of a novel human gene, ZFP91, involved in acute myelogenous leukemia."
      Unoki M., Okutsu J., Nakamura Y.
      Int. J. Oncol. 22:1217-1223(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), FUNCTION, SUBCELLULAR LOCATION.
      Tissue: Leukocyte.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ILE-37.
      Tissue: Testis.
    5. Bienvenut W.V., Waridel P., Quadroni M.
      Submitted (MAR-2009) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 2-23, CLEAVAGE OF INITIATOR METHIONINE, IDENTIFICATION BY MASS SPECTROMETRY.
      Tissue: Cervix carcinoma.
    6. "Identification of FKSG11, a novel gene related to breast cancer."
      Wang Y.-G.
      Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 67-570 (ISOFORM 1), VARIANT GLY-207.
    7. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
      Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
      Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    9. "An atypical E3 ligase zinc finger protein 91 stabilizes and activates NF-kappaB-inducing kinase via Lys63-linked ubiquitination."
      Jin X., Jin H.R., Jung H.S., Lee S.J., Lee J.H., Lee J.J.
      J. Biol. Chem. 285:30539-30547(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH MAP3K14, MUTAGENESIS OF CYS-344 AND CYS-349.
    10. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    11. "Solution structure of HR7784A."
      Northeast structural genomics consortium (NESG)
      Submitted (JUL-2013) to the PDB data bank
      Cited for: STRUCTURE BY NMR OF 370-456 IN COMPLEX WITH ZINC IONS.

    Entry informationi

    Entry nameiZFP91_HUMAN
    AccessioniPrimary (citable) accession number: Q96JP5
    Secondary accession number(s): A6NHC4
    , A8MSG7, Q86V47, Q96JP4, Q96QA3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 2005
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 118 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    In contrast to other E3 ubiquitin-protein ligase, does not contain any domain (RING-type zinc finger or HECT domain) known to mediate E3 ligase activity.

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3