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Q96JP5

- ZFP91_HUMAN

UniProt

Q96JP5 - ZFP91_HUMAN

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Protein

E3 ubiquitin-protein ligase ZFP91

Gene
ZFP91, ZNF757, FKSG11
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Atypical E3 ubiquitin-protein ligase that mediates 'Lys-63'-linked ubiquitination of MAP3K14/NIK, leading to stabilize and activate MAP3K14/NIK. It thereby acts as an activator of the non-canonical NF-kappa-B2/NFKB2 pathway. May also play an important role in cell proliferation and/or anti-apoptosis.2 Publications

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri311 – 33626C2H2-type 1Add
BLAST
Zinc fingeri342 – 36625C2H2-type 2Add
BLAST
Zinc fingeri372 – 39423C2H2-type 3Add
BLAST
Zinc fingeri400 – 42223C2H2-type 4Add
BLAST
Zinc fingeri430 – 45324C2H2-type 5Add
BLAST

GO - Molecular functioni

  1. ligase activity Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
  3. nucleic acid binding Source: InterPro
  4. ubiquitin-protein transferase activity Source: UniProtKB

GO - Biological processi

  1. activation of NF-kappaB-inducing kinase activity Source: UniProtKB
  2. protein K63-linked ubiquitination Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Ubl conjugation pathway

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
E3 ubiquitin-protein ligase ZFP91 (EC:6.3.2.-)
Alternative name(s):
Zinc finger protein 757
Zinc finger protein 91 homolog
Short name:
Zfp-91
Gene namesi
Name:ZFP91
Synonyms:ZNF757
ORF Names:FKSG11
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:14983. ZFP91.

Subcellular locationi

Nucleus 1 Publication

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi344 – 3441C → A: Abolishes ubiquitination of MAP3K14/NIK; when associated with A-349. 1 Publication
Mutagenesisi349 – 3491C → A: Abolishes ubiquitination of MAP3K14/NIK; when associated with A-344. 1 Publication

Organism-specific databases

PharmGKBiPA37955.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 570569E3 ubiquitin-protein ligase ZFP91PRO_0000047312Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei103 – 1031Phosphoserine By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ96JP5.
PaxDbiQ96JP5.
PRIDEiQ96JP5.

PTM databases

PhosphoSiteiQ96JP5.

Expressioni

Tissue specificityi

Expressed ubiquitously, particularly at high level in testis. Isoform 2 is testis specific.

Gene expression databases

ArrayExpressiQ96JP5.
BgeeiQ96JP5.
CleanExiHS_ZFP91.
GenevestigatoriQ96JP5.

Organism-specific databases

HPAiCAB025417.
HPA024037.

Interactioni

Subunit structurei

Interacts with MAP3K14/NIK.1 Publication

Protein-protein interaction databases

BioGridi123322. 10 interactions.
IntActiQ96JP5. 3 interactions.
STRINGi9606.ENSP00000339030.

Structurei

Secondary structure

1
570
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi381 – 3833
Helixi384 – 3907
Helixi391 – 3933
Beta strandi395 – 3973
Beta strandi408 – 4114
Helixi412 – 42312
Beta strandi426 – 4294
Turni433 – 4353
Helixi442 – 45211

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2M9ANMR-A370-456[»]
ProteinModelPortaliQ96JP5.
SMRiQ96JP5. Positions 313-456.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni338 – 36831Interaction with MAP3K14/NIKAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi21 – 6747Ala-richAdd
BLAST
Compositional biasi48 – 8134Arg-richAdd
BLAST
Compositional biasi197 – 28286Glu-richAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiNOG290299.
HOGENOMiHOG000155779.
HOVERGENiHBG055547.
InParanoidiQ96JP5.
OMAiGLVMNTE.
OrthoDBiEOG7SV0TZ.
PhylomeDBiQ96JP5.
TreeFamiTF332664.

Family and domain databases

Gene3Di3.30.160.60. 3 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 5 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 5 hits.
PS50157. ZINC_FINGER_C2H2_2. 4 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q96JP5-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MPGETEEPRP PEQQDQEGGE AAKAAPEEPQ QRPPEAVAAA PAGTTSSRVL    50
RGGRDRGRAA AAAAAAAVSR RRKAEYPRRR RSSPSARPPD VPGQQPQAAK 100
SPSPVQGKKS PRLLCIEKVT TDKDPKEEKE EEDDSALPQE VSIAASRPSR 150
GWRSSRTSVS RHRDTENTRS SRSKTGSLQL ICKSEPNTDQ LDYDVGEEHQ 200
SPGGISSEEE EEEEEEMLIS EEEIPFKDDP RDETYKPHLE RETPKPRRKS 250
GKVKEEKEKK EIKVEVEVEV KEEENEIRED EEPPRKRGRR RKDDKSPRLP 300
KRRKKPPIQY VRCEMEGCGT VLAHPRYLQH HIKYQHLLKK KYVCPHPSCG 350
RLFRLQKQLL RHAKHHTDQR DYICEYCARA FKSSHNLAVH RMIHTGEKPL 400
QCEICGFTCR QKASLNWHMK KHDADSFYQF SCNICGKKFE KKDSVVAHKA 450
KSHPEVLIAE ALAANAGALI TSTDILGTNP ESLTQPSDGQ GLPLLPEPLG 500
NSTSGECLLL EAEGMSKSYC SGTERVSLMA DGKIFVGSGS SGGTEGLVMN 550
SDILGATTEV LIEDSDSAGP 570
Length:570
Mass (Da):63,445
Last modified:December 1, 2001 - v1
Checksum:i476F4C21DD453522
GO
Isoform 2 (identifier: Q96JP5-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     526-529: VSLM → SIHR
     530-570: Missing.

Show »
Length:529
Mass (Da):59,571
Checksum:iD181F0420D5D004F
GO

Sequence cautioni

The sequence AAL09963.1 differs from that shown. Reason: Frameshift at positions 72 and 80.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti37 – 371V → I.1 Publication
Corresponds to variant rs17854702 [ dbSNP | Ensembl ].
VAR_032454
Natural varianti207 – 2071S → G.1 Publication
Corresponds to variant rs8373 [ dbSNP | Ensembl ].
VAR_021889

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei526 – 5294VSLM → SIHR in isoform 2. VSP_012686
Alternative sequencei530 – 57041Missing in isoform 2. VSP_012687Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti74 – 741A → V in AAL09963. 1 Publication
Sequence conflicti206 – 2061Missing in AAH51743. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB056107 mRNA. Translation: BAB63373.1.
AB057443 mRNA. Translation: BAB63374.1.
AP001350 Genomic DNA. No translation available.
CH471076 Genomic DNA. Translation: EAW73811.1.
BC051743 mRNA. Translation: AAH51743.1.
AF310246 mRNA. Translation: AAL09963.1. Frameshift.
CCDSiCCDS31553.1. [Q96JP5-1]
RefSeqiNP_001183980.1. NM_001197051.1.
NP_444251.1. NM_053023.4. [Q96JP5-1]
UniGeneiHs.524920.

Genome annotation databases

EnsembliENST00000316059; ENSP00000339030; ENSG00000186660. [Q96JP5-1]
GeneIDi80829.
KEGGihsa:80829.
UCSCiuc001nmx.4. human. [Q96JP5-1]

Polymorphism databases

DMDMi60416377.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB056107 mRNA. Translation: BAB63373.1 .
AB057443 mRNA. Translation: BAB63374.1 .
AP001350 Genomic DNA. No translation available.
CH471076 Genomic DNA. Translation: EAW73811.1 .
BC051743 mRNA. Translation: AAH51743.1 .
AF310246 mRNA. Translation: AAL09963.1 . Frameshift.
CCDSi CCDS31553.1. [Q96JP5-1 ]
RefSeqi NP_001183980.1. NM_001197051.1.
NP_444251.1. NM_053023.4. [Q96JP5-1 ]
UniGenei Hs.524920.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2M9A NMR - A 370-456 [» ]
ProteinModelPortali Q96JP5.
SMRi Q96JP5. Positions 313-456.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 123322. 10 interactions.
IntActi Q96JP5. 3 interactions.
STRINGi 9606.ENSP00000339030.

PTM databases

PhosphoSitei Q96JP5.

Polymorphism databases

DMDMi 60416377.

Proteomic databases

MaxQBi Q96JP5.
PaxDbi Q96JP5.
PRIDEi Q96JP5.

Protocols and materials databases

DNASUi 80829.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000316059 ; ENSP00000339030 ; ENSG00000186660 . [Q96JP5-1 ]
GeneIDi 80829.
KEGGi hsa:80829.
UCSCi uc001nmx.4. human. [Q96JP5-1 ]

Organism-specific databases

CTDi 80829.
GeneCardsi GC11P058347.
HGNCi HGNC:14983. ZFP91.
HPAi CAB025417.
HPA024037.
neXtProti NX_Q96JP5.
PharmGKBi PA37955.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG290299.
HOGENOMi HOG000155779.
HOVERGENi HBG055547.
InParanoidi Q96JP5.
OMAi GLVMNTE.
OrthoDBi EOG7SV0TZ.
PhylomeDBi Q96JP5.
TreeFami TF332664.

Enzyme and pathway databases

UniPathwayi UPA00143 .

Miscellaneous databases

ChiTaRSi ZFP91. human.
GeneWikii ZFP91.
GenomeRNAii 80829.
NextBioi 71236.
PROi Q96JP5.

Gene expression databases

ArrayExpressi Q96JP5.
Bgeei Q96JP5.
CleanExi HS_ZFP91.
Genevestigatori Q96JP5.

Family and domain databases

Gene3Di 3.30.160.60. 3 hits.
InterProi IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view ]
Pfami PF00096. zf-C2H2. 1 hit.
[Graphical view ]
SMARTi SM00355. ZnF_C2H2. 5 hits.
[Graphical view ]
PROSITEi PS00028. ZINC_FINGER_C2H2_1. 5 hits.
PS50157. ZINC_FINGER_C2H2_2. 4 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of a novel human gene, ZFP91, involved in acute myelogenous leukemia."
    Unoki M., Okutsu J., Nakamura Y.
    Int. J. Oncol. 22:1217-1223(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), FUNCTION, SUBCELLULAR LOCATION.
    Tissue: Leukocyte.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ILE-37.
    Tissue: Testis.
  5. Bienvenut W.V., Waridel P., Quadroni M.
    Submitted (MAR-2009) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 2-23, CLEAVAGE OF INITIATOR METHIONINE, IDENTIFICATION BY MASS SPECTROMETRY.
    Tissue: Cervix carcinoma.
  6. "Identification of FKSG11, a novel gene related to breast cancer."
    Wang Y.-G.
    Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 67-570 (ISOFORM 1), VARIANT GLY-207.
  7. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
    Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
    Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  9. "An atypical E3 ligase zinc finger protein 91 stabilizes and activates NF-kappaB-inducing kinase via Lys63-linked ubiquitination."
    Jin X., Jin H.R., Jung H.S., Lee S.J., Lee J.H., Lee J.J.
    J. Biol. Chem. 285:30539-30547(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH MAP3K14, MUTAGENESIS OF CYS-344 AND CYS-349.
  10. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  11. "Solution structure of HR7784A."
    Northeast structural genomics consortium (NESG)
    Submitted (JUL-2013) to the PDB data bank
    Cited for: STRUCTURE BY NMR OF 370-456 IN COMPLEX WITH ZINC IONS.

Entry informationi

Entry nameiZFP91_HUMAN
AccessioniPrimary (citable) accession number: Q96JP5
Secondary accession number(s): A6NHC4
, A8MSG7, Q86V47, Q96JP4, Q96QA3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: December 1, 2001
Last modified: September 3, 2014
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

In contrast to other E3 ubiquitin-protein ligase, does not contain any domain (RING-type zinc finger or HECT domain) known to mediate E3 ligase activity.

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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