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Q96JP2

- MY15B_HUMAN

UniProt

Q96JP2 - MY15B_HUMAN

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Protein

Unconventional myosin-XVB

Gene

MYO15B

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Unknown, due to the absence of a functional motor domain.

GO - Molecular functioni

  1. ATP binding Source: InterPro
  2. motor activity Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Unconventional myosin-XVB
Alternative name(s):
Myosin XVBP
Unconventional myosin-15B
Gene namesi
Name:MYO15B
Synonyms:KIAA1783, MYO15BP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Unplaced

Organism-specific databases

HGNCiHGNC:14083. MYO15B.

Subcellular locationi

Cytoplasm Curated

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. myosin complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 15301530Unconventional myosin-XVBPRO_0000292047Add
BLAST

Proteomic databases

MaxQBiQ96JP2.
PaxDbiQ96JP2.
PRIDEiQ96JP2.

PTM databases

PhosphoSiteiQ96JP2.

Expressioni

Tissue specificityi

Detected in brain, stomach and kidney.

Gene expression databases

BgeeiQ96JP2.
GenevestigatoriQ96JP2.

Organism-specific databases

HPAiHPA023377.

Interactioni

Protein-protein interaction databases

IntActiQ96JP2. 2 interactions.
MINTiMINT-5001895.
STRINGi9606.ENSP00000293201.

Structurei

Secondary structure

1
1530
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi1426 – 14316Combined sources
Beta strandi1436 – 14405Combined sources
Beta strandi1448 – 14514Combined sources
Beta strandi1461 – 14688Combined sources
Beta strandi1470 – 14745Combined sources
Beta strandi1477 – 14804Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2DLPNMR-A1424-1495[»]
ProteinModelPortaliQ96JP2.
SMRiQ96JP2. Positions 116-449, 1242-1495.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ96JP2.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 335335Myosin motorAdd
BLAST
Domaini355 – 38430IQPROSITE-ProRule annotationAdd
BLAST
Domaini492 – 643152MyTH4PROSITE-ProRule annotationAdd
BLAST
Domaini1422 – 148362SH3PROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi722 – 76342Pro-richAdd
BLAST
Compositional biasi820 – 86546Met/Pro-richAdd
BLAST
Compositional biasi871 – 91040Gln-richAdd
BLAST
Compositional biasi999 – 101921Glu-richAdd
BLAST
Compositional biasi1024 – 1204181Pro-richAdd
BLAST

Sequence similaritiesi

Contains 1 IQ domain.PROSITE-ProRule annotation
Contains 1 myosin motor domain.Curated
Contains 1 MyTH4 domain.PROSITE-ProRule annotation
Contains 1 SH3 domain.PROSITE-ProRule annotation

Keywords - Domaini

SH3 domain

Phylogenomic databases

eggNOGiCOG5022.
HOGENOMiHOG000169369.
HOVERGENiHBG108162.
InParanoidiQ96JP2.
PhylomeDBiQ96JP2.

Family and domain databases

InterProiIPR000048. IQ_motif_EF-hand-BS.
IPR001609. Myosin_head_motor_dom.
IPR000857. MyTH4_dom.
IPR027417. P-loop_NTPase.
IPR011511. SH3_2.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF00063. Myosin_head. 1 hit.
PF00784. MyTH4. 1 hit.
PF07653. SH3_2. 1 hit.
[Graphical view]
SMARTiSM00015. IQ. 1 hit.
SM00242. MYSc. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiPS50096. IQ. 1 hit.
PS51456. MYOSIN_MOTOR. 1 hit.
PS51016. MYTH4. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96JP2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKEASGVGGG HSPMCPPHCH MPPGPAGEWP GATVQQPRQR APTALLQPDA
60 70 80 90 100
AGPGGGGVSA GVAVLGACPS ASEGVLPRPP GRSAPQPPEY PGRPDMAVPG
110 120 130 140 150
WSAMVRSRLT ATSTSQATDH TFLQKSHYHH GDHPSYAKPR LPLPVFTVRH
160 170 180 190 200
YAGTVTYQVH KFLNRNRDQL DPAVVEMLGQ SQLQLVGSLF QEAEPQSRGG
210 220 230 240 250
RGRPTLASRF QQALEDLIAR LGRSHVYFIQ CLTPNPGKLP GLFDVGHVTE
260 270 280 290 300
QLHQAAILEA VGTRSANFPV RVPFEAFLAS FQALGSEGQE DLSDREKCGA
310 320 330 340 350
VLSQVLGAES PLYHLGATKV LLQEQGWQRL EELRDQQRSQ ALVDLHRSFH
360 370 380 390 400
TCISRQRVLP RMQARMRGFQ ARKRYLRRRA ALGQLNTILL VAQPLLQRRQ
410 420 430 440 450
RLQLGRWQGW HSSERALERV PSMELGRLEI PAELAVMLKT AESHRDALAG
460 470 480 490 500
SITECLPPEV PARPSLTLPA DIDLFPFSSF VAIGFQEPSL PRPGQPLAKP
510 520 530 540 550
LTQLDGDNPQ RALDINKVML RLLGDGSLES WQRQIMGAYL VRQGQCWPGL
560 570 580 590 600
RNELFSQLVA QLWQNPDEQQ SQRGWALMAV LLSAFPPLPV LQKPLLKFVS
610 620 630 640 650
DQAPRGMAAL CQHKLLGALE QSQLASGATR AHPPTQLEWL AGWRRGRMAL
660 670 680 690 700
DVFTFSEECY SAEVESWTTG EQLAGWILQS RGLEAPPRGW SVSLHSRDAW
710 720 730 740 750
QDLAGCDFVL DLISQTEDLG DPARPRSYPI TPLGSAEAIP LAPGIQAPSL
760 770 780 790 800
PPGPPPGPAP TLPSRDHTGE VQRSGSLDGF LDQIFQPVIS SGLSDLEQSW
810 820 830 840 850
ALSSRMKGGG AIGPTQQGYP MVYPGMIQMP AYQPGMVPAP MPMMPAMGTV
860 870 880 890 900
PAMPAMVVPP QPPLPSLDAG QLAVQQQNFI QQQALILAQQ MTAQAMSLSL
910 920 930 940 950
EQQMQQRQQQ ARASEAASQA SPSAVTSKPR KPPTPPEKPQ RDLGSEGGCL
960 970 980 990 1000
RETSEEAEDR PYQPKSFQQK RNYFQRMGQP QITVRTMKPP AKVHIPQGEA
1010 1020 1030 1040 1050
QEEEEEEEEE EEQEEQEVET RAVPSPPPPP IVKKPLKQGG AKAPKEAEAE
1060 1070 1080 1090 1100
PAKETAAKGH GQGPAQGRGT VVRSSDSKPK RPQPSREIGN IIRMYQSRPG
1110 1120 1130 1140 1150
PVPVPVQPSR PPKAFLRKID PKDEALAKLG INGAHSSPPM LSPSPGKGPP
1160 1170 1180 1190 1200
PAVAPRPKAP LQLGPSSSIK EKQGPLLDLF GQKLPIAHTP PPPPAPPLPL
1210 1220 1230 1240 1250
PEDPGTLSAE RRCLTQPVED QGVSTQLLAP SGSVCFSYTG TPWKLFLRKE
1260 1270 1280 1290 1300
VFYPRENFSH PYYLRLLCEQ ILRDTFSESC IRISQNERRK MKDLLGGLEV
1310 1320 1330 1340 1350
DLDSLTTTED SVKKRIVVAA RDNWANYFSR FFPVSGESGS DVQLLAVSHR
1360 1370 1380 1390 1400
GLRLLKVTQG PGLRPDQLKI LCSYSFAEVL GVECRGGSTL ELSLKSEQLV
1410 1420 1430 1440 1450
LHTARARAIE ALVELFLNEL KKDSGYVIAL RSYITDNCSL LSFHRGDLIK
1460 1470 1480 1490 1500
LLPVATLEPG WQFGSAGGRS GLFPADIVQP AAAPDFSFSK EQRSGWHKGQ
1510 1520 1530
LSNGEPGLAR WDRASEVRKM GEGQAEARPA
Length:1,530
Mass (Da):167,118
Last modified:June 26, 2007 - v2
Checksum:iE35AC826A367CA52
GO

Sequence cautioni

The sequence BAB47412.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF418286 mRNA. No translation available.
AF418287 mRNA. No translation available.
AF418288 mRNA. No translation available.
AF418289 mRNA. No translation available.
AF418290 mRNA. No translation available.
AF418291 mRNA. No translation available.
AF418292 mRNA. No translation available.
AF418293 mRNA. No translation available.
AB058686 mRNA. Translation: BAB47412.1. Different initiation.
UniGeneiHs.390817.

Genome annotation databases

UCSCiuc002jon.1. human.

Polymorphism databases

DMDMi150384690.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF418286 mRNA. No translation available.
AF418287 mRNA. No translation available.
AF418288 mRNA. No translation available.
AF418289 mRNA. No translation available.
AF418290 mRNA. No translation available.
AF418291 mRNA. No translation available.
AF418292 mRNA. No translation available.
AF418293 mRNA. No translation available.
AB058686 mRNA. Translation: BAB47412.1 . Different initiation.
UniGenei Hs.390817.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2DLP NMR - A 1424-1495 [» ]
ProteinModelPortali Q96JP2.
SMRi Q96JP2. Positions 116-449, 1242-1495.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q96JP2. 2 interactions.
MINTi MINT-5001895.
STRINGi 9606.ENSP00000293201.

PTM databases

PhosphoSitei Q96JP2.

Polymorphism databases

DMDMi 150384690.

Proteomic databases

MaxQBi Q96JP2.
PaxDbi Q96JP2.
PRIDEi Q96JP2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

UCSCi uc002jon.1. human.

Organism-specific databases

GeneCardsi GC17P073586.
HGNCi HGNC:14083. MYO15B.
HPAi HPA023377.
neXtProti NX_Q96JP2.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5022.
HOGENOMi HOG000169369.
HOVERGENi HBG108162.
InParanoidi Q96JP2.
PhylomeDBi Q96JP2.

Miscellaneous databases

ChiTaRSi MYO15B. human.
EvolutionaryTracei Q96JP2.

Gene expression databases

Bgeei Q96JP2.
Genevestigatori Q96JP2.

Family and domain databases

InterProi IPR000048. IQ_motif_EF-hand-BS.
IPR001609. Myosin_head_motor_dom.
IPR000857. MyTH4_dom.
IPR027417. P-loop_NTPase.
IPR011511. SH3_2.
IPR001452. SH3_domain.
[Graphical view ]
Pfami PF00063. Myosin_head. 1 hit.
PF00784. MyTH4. 1 hit.
PF07653. SH3_2. 1 hit.
[Graphical view ]
SMARTi SM00015. IQ. 1 hit.
SM00242. MYSc. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view ]
SUPFAMi SSF50044. SSF50044. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEi PS50096. IQ. 1 hit.
PS51456. MYOSIN_MOTOR. 1 hit.
PS51016. MYTH4. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA], ALTERNATIVE SPLICING, LACK OF FUNCTIONAL MOTOR DOMAIN.
    Tissue: Kidney and Stomach.
  2. "Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Nakayama M., Nakajima D., Kikuno R., Ohara O.
    DNA Res. 8:85-95(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  3. Cited for: IDENTIFICATION.
  4. "Solution structure of the SH3 domain of human KIAA1783 protein."
    RIKEN structural genomics initiative (RSGI)
    Submitted (OCT-2006) to the PDB data bank
    Cited for: STRUCTURE BY NMR OF 1424-1495.

Entry informationi

Entry nameiMY15B_HUMAN
AccessioniPrimary (citable) accession number: Q96JP2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: June 26, 2007
Last modified: November 26, 2014
This is version 98 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Was thought be the product of a pseudogene due to the substitution or deletion of many conserved amino acids in the motor domain. However it has been observed with several high-quality proteotypic peptides in several independent proteomic studies.Curated
Represents an unconventional myosin. This protein should not be confused with the conventional myosin-15 (MYH15).Curated

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3