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Q96JP2

- MY15B_HUMAN

UniProt

Q96JP2 - MY15B_HUMAN

Protein

Unconventional myosin-XVB

Gene

MYO15B

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 96 (01 Oct 2014)
      Sequence version 2 (26 Jun 2007)
      Previous versions | rss
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    Functioni

    Unknown, due to the absence of a functional motor domain.

    GO - Molecular functioni

    1. ATP binding Source: InterPro
    2. motor activity Source: InterPro

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Unconventional myosin-XVB
    Alternative name(s):
    Myosin XVBP
    Unconventional myosin-15B
    Gene namesi
    Name:MYO15B
    Synonyms:KIAA1783, MYO15BP
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Unplaced

    Organism-specific databases

    HGNCiHGNC:14083. MYO15B.

    Subcellular locationi

    Cytoplasm Curated

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. myosin complex Source: InterPro

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 15301530Unconventional myosin-XVBPRO_0000292047Add
    BLAST

    Proteomic databases

    MaxQBiQ96JP2.
    PaxDbiQ96JP2.
    PRIDEiQ96JP2.

    PTM databases

    PhosphoSiteiQ96JP2.

    Expressioni

    Tissue specificityi

    Detected in brain, stomach and kidney.

    Gene expression databases

    ArrayExpressiQ96JP2.
    BgeeiQ96JP2.
    GenevestigatoriQ96JP2.

    Organism-specific databases

    HPAiHPA023377.

    Interactioni

    Protein-protein interaction databases

    IntActiQ96JP2. 2 interactions.
    MINTiMINT-5001895.
    STRINGi9606.ENSP00000293201.

    Structurei

    Secondary structure

    1
    1530
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi1426 – 14316
    Beta strandi1436 – 14405
    Beta strandi1448 – 14514
    Beta strandi1461 – 14688
    Beta strandi1470 – 14745
    Beta strandi1477 – 14804

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2DLPNMR-A1424-1495[»]
    ProteinModelPortaliQ96JP2.
    SMRiQ96JP2. Positions 84-449, 1242-1495.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ96JP2.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini1 – 335335Myosin motorAdd
    BLAST
    Domaini355 – 38430IQPROSITE-ProRule annotationAdd
    BLAST
    Domaini492 – 643152MyTH4PROSITE-ProRule annotationAdd
    BLAST
    Domaini1422 – 148362SH3PROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi722 – 76342Pro-richAdd
    BLAST
    Compositional biasi820 – 86546Met/Pro-richAdd
    BLAST
    Compositional biasi871 – 91040Gln-richAdd
    BLAST
    Compositional biasi999 – 101921Glu-richAdd
    BLAST
    Compositional biasi1024 – 1204181Pro-richAdd
    BLAST

    Sequence similaritiesi

    Contains 1 IQ domain.PROSITE-ProRule annotation
    Contains 1 myosin motor domain.Curated
    Contains 1 MyTH4 domain.PROSITE-ProRule annotation
    Contains 1 SH3 domain.PROSITE-ProRule annotation

    Keywords - Domaini

    SH3 domain

    Phylogenomic databases

    eggNOGiCOG5022.
    HOGENOMiHOG000169369.
    HOVERGENiHBG108162.
    InParanoidiQ96JP2.
    PhylomeDBiQ96JP2.

    Family and domain databases

    InterProiIPR000048. IQ_motif_EF-hand-BS.
    IPR001609. Myosin_head_motor_dom.
    IPR000857. MyTH4_dom.
    IPR027417. P-loop_NTPase.
    IPR011511. SH3_2.
    IPR001452. SH3_domain.
    [Graphical view]
    PfamiPF00063. Myosin_head. 1 hit.
    PF00784. MyTH4. 1 hit.
    PF07653. SH3_2. 1 hit.
    [Graphical view]
    SMARTiSM00015. IQ. 1 hit.
    SM00242. MYSc. 1 hit.
    SM00326. SH3. 1 hit.
    [Graphical view]
    SUPFAMiSSF50044. SSF50044. 1 hit.
    SSF52540. SSF52540. 1 hit.
    PROSITEiPS50096. IQ. 1 hit.
    PS51456. MYOSIN_MOTOR. 1 hit.
    PS51016. MYTH4. 1 hit.
    PS50002. SH3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q96JP2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKEASGVGGG HSPMCPPHCH MPPGPAGEWP GATVQQPRQR APTALLQPDA     50
    AGPGGGGVSA GVAVLGACPS ASEGVLPRPP GRSAPQPPEY PGRPDMAVPG 100
    WSAMVRSRLT ATSTSQATDH TFLQKSHYHH GDHPSYAKPR LPLPVFTVRH 150
    YAGTVTYQVH KFLNRNRDQL DPAVVEMLGQ SQLQLVGSLF QEAEPQSRGG 200
    RGRPTLASRF QQALEDLIAR LGRSHVYFIQ CLTPNPGKLP GLFDVGHVTE 250
    QLHQAAILEA VGTRSANFPV RVPFEAFLAS FQALGSEGQE DLSDREKCGA 300
    VLSQVLGAES PLYHLGATKV LLQEQGWQRL EELRDQQRSQ ALVDLHRSFH 350
    TCISRQRVLP RMQARMRGFQ ARKRYLRRRA ALGQLNTILL VAQPLLQRRQ 400
    RLQLGRWQGW HSSERALERV PSMELGRLEI PAELAVMLKT AESHRDALAG 450
    SITECLPPEV PARPSLTLPA DIDLFPFSSF VAIGFQEPSL PRPGQPLAKP 500
    LTQLDGDNPQ RALDINKVML RLLGDGSLES WQRQIMGAYL VRQGQCWPGL 550
    RNELFSQLVA QLWQNPDEQQ SQRGWALMAV LLSAFPPLPV LQKPLLKFVS 600
    DQAPRGMAAL CQHKLLGALE QSQLASGATR AHPPTQLEWL AGWRRGRMAL 650
    DVFTFSEECY SAEVESWTTG EQLAGWILQS RGLEAPPRGW SVSLHSRDAW 700
    QDLAGCDFVL DLISQTEDLG DPARPRSYPI TPLGSAEAIP LAPGIQAPSL 750
    PPGPPPGPAP TLPSRDHTGE VQRSGSLDGF LDQIFQPVIS SGLSDLEQSW 800
    ALSSRMKGGG AIGPTQQGYP MVYPGMIQMP AYQPGMVPAP MPMMPAMGTV 850
    PAMPAMVVPP QPPLPSLDAG QLAVQQQNFI QQQALILAQQ MTAQAMSLSL 900
    EQQMQQRQQQ ARASEAASQA SPSAVTSKPR KPPTPPEKPQ RDLGSEGGCL 950
    RETSEEAEDR PYQPKSFQQK RNYFQRMGQP QITVRTMKPP AKVHIPQGEA 1000
    QEEEEEEEEE EEQEEQEVET RAVPSPPPPP IVKKPLKQGG AKAPKEAEAE 1050
    PAKETAAKGH GQGPAQGRGT VVRSSDSKPK RPQPSREIGN IIRMYQSRPG 1100
    PVPVPVQPSR PPKAFLRKID PKDEALAKLG INGAHSSPPM LSPSPGKGPP 1150
    PAVAPRPKAP LQLGPSSSIK EKQGPLLDLF GQKLPIAHTP PPPPAPPLPL 1200
    PEDPGTLSAE RRCLTQPVED QGVSTQLLAP SGSVCFSYTG TPWKLFLRKE 1250
    VFYPRENFSH PYYLRLLCEQ ILRDTFSESC IRISQNERRK MKDLLGGLEV 1300
    DLDSLTTTED SVKKRIVVAA RDNWANYFSR FFPVSGESGS DVQLLAVSHR 1350
    GLRLLKVTQG PGLRPDQLKI LCSYSFAEVL GVECRGGSTL ELSLKSEQLV 1400
    LHTARARAIE ALVELFLNEL KKDSGYVIAL RSYITDNCSL LSFHRGDLIK 1450
    LLPVATLEPG WQFGSAGGRS GLFPADIVQP AAAPDFSFSK EQRSGWHKGQ 1500
    LSNGEPGLAR WDRASEVRKM GEGQAEARPA 1530
    Length:1,530
    Mass (Da):167,118
    Last modified:June 26, 2007 - v2
    Checksum:iE35AC826A367CA52
    GO

    Sequence cautioni

    The sequence BAB47412.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF418286 mRNA. No translation available.
    AF418287 mRNA. No translation available.
    AF418288 mRNA. No translation available.
    AF418289 mRNA. No translation available.
    AF418290 mRNA. No translation available.
    AF418291 mRNA. No translation available.
    AF418292 mRNA. No translation available.
    AF418293 mRNA. No translation available.
    AB058686 mRNA. Translation: BAB47412.1. Different initiation.
    UniGeneiHs.390817.

    Genome annotation databases

    UCSCiuc002jon.1. human.

    Polymorphism databases

    DMDMi150384690.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF418286 mRNA. No translation available.
    AF418287 mRNA. No translation available.
    AF418288 mRNA. No translation available.
    AF418289 mRNA. No translation available.
    AF418290 mRNA. No translation available.
    AF418291 mRNA. No translation available.
    AF418292 mRNA. No translation available.
    AF418293 mRNA. No translation available.
    AB058686 mRNA. Translation: BAB47412.1 . Different initiation.
    UniGenei Hs.390817.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2DLP NMR - A 1424-1495 [» ]
    ProteinModelPortali Q96JP2.
    SMRi Q96JP2. Positions 84-449, 1242-1495.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q96JP2. 2 interactions.
    MINTi MINT-5001895.
    STRINGi 9606.ENSP00000293201.

    PTM databases

    PhosphoSitei Q96JP2.

    Polymorphism databases

    DMDMi 150384690.

    Proteomic databases

    MaxQBi Q96JP2.
    PaxDbi Q96JP2.
    PRIDEi Q96JP2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    UCSCi uc002jon.1. human.

    Organism-specific databases

    GeneCardsi GC17P073586.
    HGNCi HGNC:14083. MYO15B.
    HPAi HPA023377.
    neXtProti NX_Q96JP2.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5022.
    HOGENOMi HOG000169369.
    HOVERGENi HBG108162.
    InParanoidi Q96JP2.
    PhylomeDBi Q96JP2.

    Miscellaneous databases

    ChiTaRSi MYO15B. human.
    EvolutionaryTracei Q96JP2.

    Gene expression databases

    ArrayExpressi Q96JP2.
    Bgeei Q96JP2.
    Genevestigatori Q96JP2.

    Family and domain databases

    InterProi IPR000048. IQ_motif_EF-hand-BS.
    IPR001609. Myosin_head_motor_dom.
    IPR000857. MyTH4_dom.
    IPR027417. P-loop_NTPase.
    IPR011511. SH3_2.
    IPR001452. SH3_domain.
    [Graphical view ]
    Pfami PF00063. Myosin_head. 1 hit.
    PF00784. MyTH4. 1 hit.
    PF07653. SH3_2. 1 hit.
    [Graphical view ]
    SMARTi SM00015. IQ. 1 hit.
    SM00242. MYSc. 1 hit.
    SM00326. SH3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50044. SSF50044. 1 hit.
    SSF52540. SSF52540. 1 hit.
    PROSITEi PS50096. IQ. 1 hit.
    PS51456. MYOSIN_MOTOR. 1 hit.
    PS51016. MYTH4. 1 hit.
    PS50002. SH3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA], ALTERNATIVE SPLICING, LACK OF FUNCTIONAL MOTOR DOMAIN.
      Tissue: Kidney and Stomach.
    2. "Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
      Nagase T., Nakayama M., Nakajima D., Kikuno R., Ohara O.
      DNA Res. 8:85-95(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    3. Cited for: IDENTIFICATION.
    4. "Solution structure of the SH3 domain of human KIAA1783 protein."
      RIKEN structural genomics initiative (RSGI)
      Submitted (OCT-2006) to the PDB data bank
      Cited for: STRUCTURE BY NMR OF 1424-1495.

    Entry informationi

    Entry nameiMY15B_HUMAN
    AccessioniPrimary (citable) accession number: Q96JP2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 26, 2007
    Last sequence update: June 26, 2007
    Last modified: October 1, 2014
    This is version 96 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    Was thought be the product of a pseudogene due to the substitution or deletion of many conserved amino acids in the motor domain. However it has been observed with several high-quality proteotypic peptides in several independent proteomic studies.Curated
    Represents an unconventional myosin. This protein should not be confused with the conventional myosin-15 (MYH15).Curated

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3