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Protein

Unconventional myosin-XVB

Gene

MYO15B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Unknown, due to the absence of a functional motor domain.

Caution

Was thought be the product of a pseudogene due to the substitution or deletion of many conserved amino acids in the motor domain. However it has been observed with several high-quality proteotypic peptides in several independent proteomic studies.Curated
Represents an unconventional myosin. This protein should not be confused with the conventional myosin-15 (MYH15).Curated

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Unconventional myosin-XVB
Alternative name(s):
Myosin XVBP
Unconventional myosin-15B
Gene namesi
Name:MYO15B
Synonyms:KIAA1783, MYO15BP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

EuPathDBiHostDB:ENSG00000266714.6
HGNCiHGNC:14083 MYO15B
neXtProtiNX_Q96JP2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000266714

Polymorphism and mutation databases

DMDMi150384690

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002920471 – 1530Unconventional myosin-XVBAdd BLAST1530

Proteomic databases

EPDiQ96JP2
MaxQBiQ96JP2
PaxDbiQ96JP2
PeptideAtlasiQ96JP2
PRIDEiQ96JP2

Expressioni

Tissue specificityi

Detected in brain, stomach and kidney.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ96JP2 2 interactors.
MINTiQ96JP2
STRINGi9606.ENSP00000463645

Structurei

Secondary structure

11530
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi1426 – 1431Combined sources6
Beta strandi1436 – 1440Combined sources5
Beta strandi1448 – 1451Combined sources4
Beta strandi1461 – 1468Combined sources8
Beta strandi1470 – 1474Combined sources5
Beta strandi1477 – 1480Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DLPNMR-A1424-1495[»]
ProteinModelPortaliQ96JP2
SMRiQ96JP2
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ96JP2

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 335Myosin motorPROSITE-ProRule annotationAdd BLAST335
Domaini355 – 384IQPROSITE-ProRule annotationAdd BLAST30
Domaini492 – 643MyTH4PROSITE-ProRule annotationAdd BLAST152
Domaini1422 – 1483SH3PROSITE-ProRule annotationAdd BLAST62

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi722 – 763Pro-richAdd BLAST42
Compositional biasi820 – 865Met/Pro-richAdd BLAST46
Compositional biasi871 – 910Gln-richAdd BLAST40
Compositional biasi999 – 1019Glu-richAdd BLAST21
Compositional biasi1024 – 1204Pro-richAdd BLAST181

Sequence similaritiesi

Keywords - Domaini

SH3 domain

Phylogenomic databases

eggNOGiKOG4229 Eukaryota
COG5022 LUCA
GeneTreeiENSGT00900000140810
HOGENOMiHOG000169369
HOVERGENiHBG108162
InParanoidiQ96JP2
KOiK10361
PhylomeDBiQ96JP2

Family and domain databases

CDDicd12068 SH3_MYO15B, 1 hit
Gene3Di1.25.40.5301 hit
2.30.29.301 hit
InterProiView protein in InterPro
IPR000048 IQ_motif_EF-hand-BS
IPR035489 MYO15B_SH3
IPR001609 Myosin_head_motor_dom
IPR000857 MyTH4_dom
IPR038185 MyTH4_dom_sf
IPR027417 P-loop_NTPase
IPR011993 PH-like_dom_sf
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
PfamiView protein in Pfam
PF00063 Myosin_head, 1 hit
PF00784 MyTH4, 1 hit
PF07653 SH3_2, 1 hit
SMARTiView protein in SMART
SM00242 MYSc, 1 hit
SM00139 MyTH4, 1 hit
SM00326 SH3, 1 hit
SUPFAMiSSF50044 SSF50044, 1 hit
SSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS50096 IQ, 1 hit
PS51456 MYOSIN_MOTOR, 1 hit
PS51016 MYTH4, 1 hit
PS50002 SH3, 1 hit

Sequencei

Sequence statusi: Complete.

Q96JP2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKEASGVGGG HSPMCPPHCH MPPGPAGEWP GATVQQPRQR APTALLQPDA
60 70 80 90 100
AGPGGGGVSA GVAVLGACPS ASEGVLPRPP GRSAPQPPEY PGRPDMAVPG
110 120 130 140 150
WSAMVRSRLT ATSTSQATDH TFLQKSHYHH GDHPSYAKPR LPLPVFTVRH
160 170 180 190 200
YAGTVTYQVH KFLNRNRDQL DPAVVEMLGQ SQLQLVGSLF QEAEPQSRGG
210 220 230 240 250
RGRPTLASRF QQALEDLIAR LGRSHVYFIQ CLTPNPGKLP GLFDVGHVTE
260 270 280 290 300
QLHQAAILEA VGTRSANFPV RVPFEAFLAS FQALGSEGQE DLSDREKCGA
310 320 330 340 350
VLSQVLGAES PLYHLGATKV LLQEQGWQRL EELRDQQRSQ ALVDLHRSFH
360 370 380 390 400
TCISRQRVLP RMQARMRGFQ ARKRYLRRRA ALGQLNTILL VAQPLLQRRQ
410 420 430 440 450
RLQLGRWQGW HSSERALERV PSMELGRLEI PAELAVMLKT AESHRDALAG
460 470 480 490 500
SITECLPPEV PARPSLTLPA DIDLFPFSSF VAIGFQEPSL PRPGQPLAKP
510 520 530 540 550
LTQLDGDNPQ RALDINKVML RLLGDGSLES WQRQIMGAYL VRQGQCRPGL
560 570 580 590 600
RNELFSQLVA QLWQNPDEQQ SQRGWALMAV LLSAFPPLPV LQKPLLKFVS
610 620 630 640 650
DQAPRGMAAL CQHKLLGALE QSQLASGATR AHPPTQLEWL AGWRRGRMAL
660 670 680 690 700
DVFTFSEECY SAEVESWTTG EQLAGWILQS RGLEAPPRGW SVSLHSRDAW
710 720 730 740 750
QDLAGCDFVL DLISQTEDLG DPARPRSYPI TPLGSAEAIP LAPGIQAPSL
760 770 780 790 800
PPGPPPGPAP TLPSRDHTGE VQRSGSLDGF LDQIFQPVIS SGLSDLEQSW
810 820 830 840 850
ALSSRMKGGG AIGPTQQGYP MVYPGMIQMP AYQPGMVPAP MPMMPAMGTV
860 870 880 890 900
PAMPAMVVPP QPPLPSLDAG QLAVQQQNFI QQQALILAQQ MTAQAMSLSL
910 920 930 940 950
EQQMQQRQQQ ARASEAASQA SPSAVTSKPR KPPTPPEKPQ RDLGSEGGCL
960 970 980 990 1000
RETSEEAEDR PYQPKSFQQK RNYFQRMGQP QITVRTMKPP AKVHIPQGEA
1010 1020 1030 1040 1050
QEEEEEEEEE EEQEEQEVET RAVPSPPPPP IVKKPLKQGG AKAPKEAEAE
1060 1070 1080 1090 1100
PAKETAAKGH GQGPAQGRGT VVRSSDSKPK RPQPSREIGN IIRMYQSRPG
1110 1120 1130 1140 1150
PVPVPVQPSR PPKAFLRKID PKDEALAKLG INGAHSSPPM LSPSPGKGPP
1160 1170 1180 1190 1200
PAVAPRPKAP LQLGPSSSIK EKQGPLLDLF GQKLPIAHTP PPPPAPPLPL
1210 1220 1230 1240 1250
PEDPGTLSAE RRCLTQPVED QGVSTQLLAP SGSVCFSYTG TPWKLFLRKE
1260 1270 1280 1290 1300
VFYPRENFSH PYYLRLLCEQ ILRDTFSESC IRISQNERRK MKDLLGGLEV
1310 1320 1330 1340 1350
DLDSLTTTED SVKKRIVVAA RDNWANYFSR FFPVSGESGS DVQLLAVSHR
1360 1370 1380 1390 1400
GLRLLKVTQG PGLRPDQLKI LCSYSFAEVL GVECRGGSTL ELSLKSEQLV
1410 1420 1430 1440 1450
LHTARARAIE ALVELFLNEL KKDSGYVIAL RSYITDNCSL LSFHRGDLIK
1460 1470 1480 1490 1500
LLPVATLEPG WQFGSAGGRS GLFPADIVQP AAAPDFSFSK EQRSGWHKGQ
1510 1520 1530
LSNGEPGLAR WDRASEVRKM GEGQAEARPA
Length:1,530
Mass (Da):167,088
Last modified:March 28, 2018 - v3
Checksum:i5CFC724850DDA4A1
GO

Sequence cautioni

The sequence BAB47412 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_080141547R → W. Corresponds to variant dbSNP:rs3803728Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF418286 mRNA No translation available.
AF418287 mRNA No translation available.
AF418288 mRNA No translation available.
AF418289 mRNA No translation available.
AF418290 mRNA No translation available.
AF418291 mRNA No translation available.
AF418292 mRNA No translation available.
AF418293 mRNA No translation available.
AB058686 mRNA Translation: BAB47412.1 Different initiation.
AC087749 Genomic DNA No translation available.
KF511237 Genomic DNA No translation available.
RefSeqiNP_001296171.1, NM_001309242.1
UniGeneiHs.390817

Genome annotation databases

EnsembliENST00000633867; ENSP00000487744; ENSG00000266714
GeneIDi80022
KEGGihsa:80022

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiMY15B_HUMAN
AccessioniPrimary (citable) accession number: Q96JP2
Secondary accession number(s): A0A0J9YVZ6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: March 28, 2018
Last modified: April 25, 2018
This is version 120 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome