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Q96JP2

- MY15B_HUMAN

UniProt

Q96JP2 - MY15B_HUMAN

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Protein
Unconventional myosin-XVB
Gene
MYO15B, KIAA1783, MYO15BP
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Unknown, due to the absence of a functional motor domain.1 Publication

GO - Molecular functioni

  1. ATP binding Source: InterPro
  2. motor activity Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Unconventional myosin-XVB
Alternative name(s):
Myosin XVBP
Unconventional myosin-15B
Gene namesi
Name:MYO15B
Synonyms:KIAA1783, MYO15BP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Unplaced

Organism-specific databases

HGNCiHGNC:14083. MYO15B.

Subcellular locationi

Cytoplasm Reviewed prediction

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. myosin complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 15301530Unconventional myosin-XVB
PRO_0000292047Add
BLAST

Proteomic databases

MaxQBiQ96JP2.
PaxDbiQ96JP2.
PRIDEiQ96JP2.

PTM databases

PhosphoSiteiQ96JP2.

Expressioni

Tissue specificityi

Detected in brain, stomach and kidney.

Gene expression databases

ArrayExpressiQ96JP2.
BgeeiQ96JP2.
GenevestigatoriQ96JP2.

Organism-specific databases

HPAiHPA023377.

Interactioni

Protein-protein interaction databases

IntActiQ96JP2. 2 interactions.
MINTiMINT-5001895.
STRINGi9606.ENSP00000293201.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi1426 – 14316
Beta strandi1436 – 14405
Beta strandi1448 – 14514
Beta strandi1461 – 14688
Beta strandi1470 – 14745
Beta strandi1477 – 14804

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2DLPNMR-A1424-1495[»]
ProteinModelPortaliQ96JP2.
SMRiQ96JP2. Positions 84-449, 1242-1495.

Miscellaneous databases

EvolutionaryTraceiQ96JP2.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 335335Myosin motor
Add
BLAST
Domaini355 – 38430IQ
Add
BLAST
Domaini492 – 643152MyTH4
Add
BLAST
Domaini1422 – 148362SH3
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi722 – 76342Pro-rich
Add
BLAST
Compositional biasi820 – 86546Met/Pro-rich
Add
BLAST
Compositional biasi871 – 91040Gln-rich
Add
BLAST
Compositional biasi999 – 101921Glu-rich
Add
BLAST
Compositional biasi1024 – 1204181Pro-rich
Add
BLAST

Sequence similaritiesi

Contains 1 IQ domain.
Contains 1 MyTH4 domain.
Contains 1 SH3 domain.

Keywords - Domaini

SH3 domain

Phylogenomic databases

eggNOGiCOG5022.
HOGENOMiHOG000169369.
HOVERGENiHBG108162.
InParanoidiQ96JP2.
PhylomeDBiQ96JP2.

Family and domain databases

InterProiIPR000048. IQ_motif_EF-hand-BS.
IPR001609. Myosin_head_motor_dom.
IPR000857. MyTH4_dom.
IPR027417. P-loop_NTPase.
IPR011511. SH3_2.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF00063. Myosin_head. 1 hit.
PF00784. MyTH4. 1 hit.
PF07653. SH3_2. 1 hit.
[Graphical view]
SMARTiSM00015. IQ. 1 hit.
SM00242. MYSc. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiPS50096. IQ. 1 hit.
PS51456. MYOSIN_MOTOR. 1 hit.
PS51016. MYTH4. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96JP2-1 [UniParc]FASTAAdd to Basket

« Hide

MKEASGVGGG HSPMCPPHCH MPPGPAGEWP GATVQQPRQR APTALLQPDA     50
AGPGGGGVSA GVAVLGACPS ASEGVLPRPP GRSAPQPPEY PGRPDMAVPG 100
WSAMVRSRLT ATSTSQATDH TFLQKSHYHH GDHPSYAKPR LPLPVFTVRH 150
YAGTVTYQVH KFLNRNRDQL DPAVVEMLGQ SQLQLVGSLF QEAEPQSRGG 200
RGRPTLASRF QQALEDLIAR LGRSHVYFIQ CLTPNPGKLP GLFDVGHVTE 250
QLHQAAILEA VGTRSANFPV RVPFEAFLAS FQALGSEGQE DLSDREKCGA 300
VLSQVLGAES PLYHLGATKV LLQEQGWQRL EELRDQQRSQ ALVDLHRSFH 350
TCISRQRVLP RMQARMRGFQ ARKRYLRRRA ALGQLNTILL VAQPLLQRRQ 400
RLQLGRWQGW HSSERALERV PSMELGRLEI PAELAVMLKT AESHRDALAG 450
SITECLPPEV PARPSLTLPA DIDLFPFSSF VAIGFQEPSL PRPGQPLAKP 500
LTQLDGDNPQ RALDINKVML RLLGDGSLES WQRQIMGAYL VRQGQCWPGL 550
RNELFSQLVA QLWQNPDEQQ SQRGWALMAV LLSAFPPLPV LQKPLLKFVS 600
DQAPRGMAAL CQHKLLGALE QSQLASGATR AHPPTQLEWL AGWRRGRMAL 650
DVFTFSEECY SAEVESWTTG EQLAGWILQS RGLEAPPRGW SVSLHSRDAW 700
QDLAGCDFVL DLISQTEDLG DPARPRSYPI TPLGSAEAIP LAPGIQAPSL 750
PPGPPPGPAP TLPSRDHTGE VQRSGSLDGF LDQIFQPVIS SGLSDLEQSW 800
ALSSRMKGGG AIGPTQQGYP MVYPGMIQMP AYQPGMVPAP MPMMPAMGTV 850
PAMPAMVVPP QPPLPSLDAG QLAVQQQNFI QQQALILAQQ MTAQAMSLSL 900
EQQMQQRQQQ ARASEAASQA SPSAVTSKPR KPPTPPEKPQ RDLGSEGGCL 950
RETSEEAEDR PYQPKSFQQK RNYFQRMGQP QITVRTMKPP AKVHIPQGEA 1000
QEEEEEEEEE EEQEEQEVET RAVPSPPPPP IVKKPLKQGG AKAPKEAEAE 1050
PAKETAAKGH GQGPAQGRGT VVRSSDSKPK RPQPSREIGN IIRMYQSRPG 1100
PVPVPVQPSR PPKAFLRKID PKDEALAKLG INGAHSSPPM LSPSPGKGPP 1150
PAVAPRPKAP LQLGPSSSIK EKQGPLLDLF GQKLPIAHTP PPPPAPPLPL 1200
PEDPGTLSAE RRCLTQPVED QGVSTQLLAP SGSVCFSYTG TPWKLFLRKE 1250
VFYPRENFSH PYYLRLLCEQ ILRDTFSESC IRISQNERRK MKDLLGGLEV 1300
DLDSLTTTED SVKKRIVVAA RDNWANYFSR FFPVSGESGS DVQLLAVSHR 1350
GLRLLKVTQG PGLRPDQLKI LCSYSFAEVL GVECRGGSTL ELSLKSEQLV 1400
LHTARARAIE ALVELFLNEL KKDSGYVIAL RSYITDNCSL LSFHRGDLIK 1450
LLPVATLEPG WQFGSAGGRS GLFPADIVQP AAAPDFSFSK EQRSGWHKGQ 1500
LSNGEPGLAR WDRASEVRKM GEGQAEARPA 1530
Length:1,530
Mass (Da):167,118
Last modified:June 26, 2007 - v2
Checksum:iE35AC826A367CA52
GO

Sequence cautioni

The sequence BAB47412.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF418286 mRNA. No translation available.
AF418287 mRNA. No translation available.
AF418288 mRNA. No translation available.
AF418289 mRNA. No translation available.
AF418290 mRNA. No translation available.
AF418291 mRNA. No translation available.
AF418292 mRNA. No translation available.
AF418293 mRNA. No translation available.
AB058686 mRNA. Translation: BAB47412.1. Different initiation.
UniGeneiHs.390817.

Genome annotation databases

UCSCiuc002jon.1. human.

Polymorphism databases

DMDMi150384690.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF418286 mRNA. No translation available.
AF418287 mRNA. No translation available.
AF418288 mRNA. No translation available.
AF418289 mRNA. No translation available.
AF418290 mRNA. No translation available.
AF418291 mRNA. No translation available.
AF418292 mRNA. No translation available.
AF418293 mRNA. No translation available.
AB058686 mRNA. Translation: BAB47412.1 . Different initiation.
UniGenei Hs.390817.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2DLP NMR - A 1424-1495 [» ]
ProteinModelPortali Q96JP2.
SMRi Q96JP2. Positions 84-449, 1242-1495.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q96JP2. 2 interactions.
MINTi MINT-5001895.
STRINGi 9606.ENSP00000293201.

PTM databases

PhosphoSitei Q96JP2.

Polymorphism databases

DMDMi 150384690.

Proteomic databases

MaxQBi Q96JP2.
PaxDbi Q96JP2.
PRIDEi Q96JP2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

UCSCi uc002jon.1. human.

Organism-specific databases

GeneCardsi GC17P073586.
HGNCi HGNC:14083. MYO15B.
HPAi HPA023377.
neXtProti NX_Q96JP2.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5022.
HOGENOMi HOG000169369.
HOVERGENi HBG108162.
InParanoidi Q96JP2.
PhylomeDBi Q96JP2.

Miscellaneous databases

ChiTaRSi MYO15B. human.
EvolutionaryTracei Q96JP2.

Gene expression databases

ArrayExpressi Q96JP2.
Bgeei Q96JP2.
Genevestigatori Q96JP2.

Family and domain databases

InterProi IPR000048. IQ_motif_EF-hand-BS.
IPR001609. Myosin_head_motor_dom.
IPR000857. MyTH4_dom.
IPR027417. P-loop_NTPase.
IPR011511. SH3_2.
IPR001452. SH3_domain.
[Graphical view ]
Pfami PF00063. Myosin_head. 1 hit.
PF00784. MyTH4. 1 hit.
PF07653. SH3_2. 1 hit.
[Graphical view ]
SMARTi SM00015. IQ. 1 hit.
SM00242. MYSc. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view ]
SUPFAMi SSF50044. SSF50044. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEi PS50096. IQ. 1 hit.
PS51456. MYOSIN_MOTOR. 1 hit.
PS51016. MYTH4. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA], ALTERNATIVE SPLICING, LACK OF FUNCTIONAL MOTOR DOMAIN.
    Tissue: Kidney and Stomach.
  2. "Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Nakayama M., Nakajima D., Kikuno R., Ohara O.
    DNA Res. 8:85-95(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  3. Cited for: IDENTIFICATION.
  4. "Solution structure of the SH3 domain of human KIAA1783 protein."
    RIKEN structural genomics initiative (RSGI)
    Submitted (OCT-2006) to the PDB data bank
    Cited for: STRUCTURE BY NMR OF 1424-1495.

Entry informationi

Entry nameiMY15B_HUMAN
AccessioniPrimary (citable) accession number: Q96JP2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: June 26, 2007
Last modified: June 11, 2014
This is version 95 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Was thought be the product of a pseudogene due to the substitution or deletion of many conserved amino acids in the motor domain. However it has been observed with several high-quality proteotypic peptides in several independent proteomic studies.
Represents an unconventional myosin. This protein should not be confused with the conventional myosin-15 (MYH15).

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi