Putative unconventional myosin-XVB - Homo sapiens (Human)

Preferred order of sections

Names and origin

Protein names

Recommended name:
Putative unconventional myosin-XVB

Alternative name(s):
Myosin XVBP
Unconventional myosin-15B

Gene names

Name:	MYO15B
Synonyms:	KIAA1783, MYO15BP

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	1530 AA.
Sequence status	Complete.
Protein existence	Uncertain

General annotation (Comments)

Function	Unknown, due to the absence of a functional motor domain. Ref.1
Subcellular location	Cytoplasm Potential.
Tissue specificity	Detected in brain, stomach and kidney.
Sequence similarities	Contains 1 IQ domain. Contains 1 myosin head-like domain. Contains 1 MyTH4 domain. Contains 1 SH3 domain.
Caution	Could be the product of a pseudogene. Represents a unconventional myosin. This protein should not be confused with the conventional myosin-15 (MYH15).
Sequence caution	The sequence BAB47412.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Cellular component	Cytoplasm
Domain	SH3 domain
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell myosin complex Inferred from electronic annotation. Source: InterPro
Molecular_function	ATP binding Inferred from electronic annotation. Source: InterPro motor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 1530

1530

Putative unconventional myosin-XVB

PRO_0000292047

Regions

Domain

116 – 323

208

Myosin head-like

Domain

355 – 384

30

IQ

Domain

492 – 643

152

MyTH4

Domain

1422 – 1483

62

SH3

Compositional bias

722 – 763

42

Pro-rich

Compositional bias

820 – 865

46

Met/Pro-rich

Compositional bias

871 – 910

40

Gln-rich

Compositional bias

999 – 1019

21

Glu-rich

Compositional bias

1024 – 1204

181

Pro-rich

Secondary structure

1

.

1530

Helix Strand Turn

Details...

Sequences

Sequence

Length

Mass (Da)

Tools

Q96JP2 [UniParc].

Last modified June 26, 2007. Version 2.
Checksum: E35AC826A367CA52
Show »

FASTA

1,530

167,118

        10         20         30         40         50         60 
MKEASGVGGG HSPMCPPHCH MPPGPAGEWP GATVQQPRQR APTALLQPDA AGPGGGGVSA 

        70         80         90        100        110        120 
GVAVLGACPS ASEGVLPRPP GRSAPQPPEY PGRPDMAVPG WSAMVRSRLT ATSTSQATDH 

       130        140        150        160        170        180 
TFLQKSHYHH GDHPSYAKPR LPLPVFTVRH YAGTVTYQVH KFLNRNRDQL DPAVVEMLGQ 

       190        200        210        220        230        240 
SQLQLVGSLF QEAEPQSRGG RGRPTLASRF QQALEDLIAR LGRSHVYFIQ CLTPNPGKLP 

       250        260        270        280        290        300 
GLFDVGHVTE QLHQAAILEA VGTRSANFPV RVPFEAFLAS FQALGSEGQE DLSDREKCGA 

       310        320        330        340        350        360 
VLSQVLGAES PLYHLGATKV LLQEQGWQRL EELRDQQRSQ ALVDLHRSFH TCISRQRVLP 

       370        380        390        400        410        420 
RMQARMRGFQ ARKRYLRRRA ALGQLNTILL VAQPLLQRRQ RLQLGRWQGW HSSERALERV 

       430        440        450        460        470        480 
PSMELGRLEI PAELAVMLKT AESHRDALAG SITECLPPEV PARPSLTLPA DIDLFPFSSF 

       490        500        510        520        530        540 
VAIGFQEPSL PRPGQPLAKP LTQLDGDNPQ RALDINKVML RLLGDGSLES WQRQIMGAYL 

       550        560        570        580        590        600 
VRQGQCWPGL RNELFSQLVA QLWQNPDEQQ SQRGWALMAV LLSAFPPLPV LQKPLLKFVS 

       610        620        630        640        650        660 
DQAPRGMAAL CQHKLLGALE QSQLASGATR AHPPTQLEWL AGWRRGRMAL DVFTFSEECY 

       670        680        690        700        710        720 
SAEVESWTTG EQLAGWILQS RGLEAPPRGW SVSLHSRDAW QDLAGCDFVL DLISQTEDLG 

       730        740        750        760        770        780 
DPARPRSYPI TPLGSAEAIP LAPGIQAPSL PPGPPPGPAP TLPSRDHTGE VQRSGSLDGF 

       790        800        810        820        830        840 
LDQIFQPVIS SGLSDLEQSW ALSSRMKGGG AIGPTQQGYP MVYPGMIQMP AYQPGMVPAP 

       850        860        870        880        890        900 
MPMMPAMGTV PAMPAMVVPP QPPLPSLDAG QLAVQQQNFI QQQALILAQQ MTAQAMSLSL 

       910        920        930        940        950        960 
EQQMQQRQQQ ARASEAASQA SPSAVTSKPR KPPTPPEKPQ RDLGSEGGCL RETSEEAEDR 

       970        980        990       1000       1010       1020 
PYQPKSFQQK RNYFQRMGQP QITVRTMKPP AKVHIPQGEA QEEEEEEEEE EEQEEQEVET 

      1030       1040       1050       1060       1070       1080 
RAVPSPPPPP IVKKPLKQGG AKAPKEAEAE PAKETAAKGH GQGPAQGRGT VVRSSDSKPK 

      1090       1100       1110       1120       1130       1140 
RPQPSREIGN IIRMYQSRPG PVPVPVQPSR PPKAFLRKID PKDEALAKLG INGAHSSPPM 

      1150       1160       1170       1180       1190       1200 
LSPSPGKGPP PAVAPRPKAP LQLGPSSSIK EKQGPLLDLF GQKLPIAHTP PPPPAPPLPL 

      1210       1220       1230       1240       1250       1260 
PEDPGTLSAE RRCLTQPVED QGVSTQLLAP SGSVCFSYTG TPWKLFLRKE VFYPRENFSH 

      1270       1280       1290       1300       1310       1320 
PYYLRLLCEQ ILRDTFSESC IRISQNERRK MKDLLGGLEV DLDSLTTTED SVKKRIVVAA 

      1330       1340       1350       1360       1370       1380 
RDNWANYFSR FFPVSGESGS DVQLLAVSHR GLRLLKVTQG PGLRPDQLKI LCSYSFAEVL 

      1390       1400       1410       1420       1430       1440 
GVECRGGSTL ELSLKSEQLV LHTARARAIE ALVELFLNEL KKDSGYVIAL RSYITDNCSL 

      1450       1460       1470       1480       1490       1500 
LSFHRGDLIK LLPVATLEPG WQFGSAGGRS GLFPADIVQP AAAPDFSFSK EQRSGWHKGQ 

      1510       1520       1530 
LSNGEPGLAR WDRASEVRKM GEGQAEARPA

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Human myosin XVBP is a transcribed pseudogene." Boger E.T., Sellers J.R., Friedman T.B. J. Muscle Res. Cell Motil. 22:477-483(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], ALTERNATIVE SPLICING, LACK OF FUNCTIONAL MOTOR DOMAIN. Tissue: Kidney and Stomach.
[2]	"Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Nakayama M., Nakajima D., Kikuno R., Ohara O. DNA Res. 8:85-95(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[3]	"A millennial myosin census." Berg J.S., Powell B.C., Cheney R.E. Mol. Biol. Cell 12:780-794(2001) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION.
[4]	"Solution structure of the SH3 domain of human KIAA1783 protein." RIKEN structural genomics initiative (RSGI) Submitted (OCT-2006) to the PDB data bank Cited for: STRUCTURE BY NMR OF 1424-1495.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AF418286 mRNA. No translation available.
AF418287 mRNA. No translation available.
AF418288 mRNA. No translation available.
AF418289 mRNA. No translation available.
AF418290 mRNA. No translation available.
AF418291 mRNA. No translation available.
AF418292 mRNA. No translation available.
AF418293 mRNA. No translation available.
AB058686 mRNA. Translation: BAB47412.1. Different initiation.

IPI

IPI00786880.

UniGene

Hs.390817.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2DLP	NMR	-	A	1424-1495	[»]

ProteinModelPortal

Q96JP2.

ModBase

Search...

Protein-protein interaction databases

MINT

MINT-5001895.

STRING

9606.ENSP00000293201.

PTM databases

PhosphoSite

Q96JP2.

Polymorphism databases

DMDM

150384690.

Proteomic databases

PaxDb

Q96JP2.

PRIDE

Q96JP2.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

UCSC

uc002jon.1. human.

Organism-specific databases

GeneCards

GC17P073562.

HGNC

HGNC:14083. MYO15B.

neXtProt

NX_Q96JP2.

HUGE

Search...

GenAtlas

Search...

Phylogenomic databases

eggNOG

COG5022.

HOGENOM

HOG000169369.

HOVERGEN

HBG108162.

InParanoid

Q96JP2.

OrthoDB

EOG4XD3Q7.

Gene expression databases

Bgee

Q96JP2.

Genevestigator

Q96JP2.

Family and domain databases

InterPro

IPR000048. IQ_motif_EF-hand-BS.
IPR001609. Myosin_head_motor_dom.
IPR000857. MyTH4_dom.
IPR027417. P-loop_NTPase.
IPR011511. SH3_2.
IPR001452. SH3_domain.
[Graphical view]

Pfam

PF00063. Myosin_head. 1 hit.
PF00784. MyTH4. 1 hit.
PF07653. SH3_2. 1 hit.
[Graphical view]

SMART

SM00015. IQ. 1 hit.
SM00242. MYSc. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view]

SUPFAM

SSF50044. SH3. 1 hit.
SSF52540. SSF52540. 1 hit.

PROSITE

PS50096. IQ. 1 hit.
PS51016. MYTH4. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

ChiTaRS

MYO15B. human.

EvolutionaryTrace

Q96JP2.

Entry information

Entry name

MY15B_HUMAN

Accession

Primary (citable) accession number: Q96JP2

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 26, 2007
Last sequence update:	June 26, 2007
Last modified:	May 29, 2013
This is version 85 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome 17

Human chromosome 17: entries, gene names and cross-references to MIM

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families