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Q96JP2 (MY15B_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 93. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Unconventional myosin-XVB
Alternative name(s):
Myosin XVBP
Unconventional myosin-15B
Gene names
Name:MYO15B
Synonyms:KIAA1783, MYO15BP
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length1530 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Unknown, due to the absence of a functional motor domain. Ref.1

Subcellular location

Cytoplasm Potential.

Tissue specificity

Detected in brain, stomach and kidney.

Sequence similarities

Contains 1 IQ domain.

Contains 1 myosin head-like domain.

Contains 1 MyTH4 domain.

Contains 1 SH3 domain.

Caution

Was thought be the product of a pseudogene due to the substitution or deletion of many conserved amino acids in the motor domain. However it has been observed with several high-quality proteotypic peptides in several independent proteomic studies.

Represents an unconventional myosin. This protein should not be confused with the conventional myosin-15 (MYH15).

Sequence caution

The sequence BAB47412.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Cellular componentCytoplasm
   DomainSH3 domain
   Technical term3D-structure
Complete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

myosin complex

Inferred from electronic annotation. Source: InterPro

   Molecular_functionATP binding

Inferred from electronic annotation. Source: InterPro

motor activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 15301530Unconventional myosin-XVB
PRO_0000292047

Regions

Domain116 – 323208Myosin head-like
Domain355 – 38430IQ
Domain492 – 643152MyTH4
Domain1422 – 148362SH3
Compositional bias722 – 76342Pro-rich
Compositional bias820 – 86546Met/Pro-rich
Compositional bias871 – 91040Gln-rich
Compositional bias999 – 101921Glu-rich
Compositional bias1024 – 1204181Pro-rich

Secondary structure

............. 1530
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q96JP2 [UniParc].

Last modified June 26, 2007. Version 2.
Checksum: E35AC826A367CA52

FASTA1,530167,118
        10         20         30         40         50         60 
MKEASGVGGG HSPMCPPHCH MPPGPAGEWP GATVQQPRQR APTALLQPDA AGPGGGGVSA 

        70         80         90        100        110        120 
GVAVLGACPS ASEGVLPRPP GRSAPQPPEY PGRPDMAVPG WSAMVRSRLT ATSTSQATDH 

       130        140        150        160        170        180 
TFLQKSHYHH GDHPSYAKPR LPLPVFTVRH YAGTVTYQVH KFLNRNRDQL DPAVVEMLGQ 

       190        200        210        220        230        240 
SQLQLVGSLF QEAEPQSRGG RGRPTLASRF QQALEDLIAR LGRSHVYFIQ CLTPNPGKLP 

       250        260        270        280        290        300 
GLFDVGHVTE QLHQAAILEA VGTRSANFPV RVPFEAFLAS FQALGSEGQE DLSDREKCGA 

       310        320        330        340        350        360 
VLSQVLGAES PLYHLGATKV LLQEQGWQRL EELRDQQRSQ ALVDLHRSFH TCISRQRVLP 

       370        380        390        400        410        420 
RMQARMRGFQ ARKRYLRRRA ALGQLNTILL VAQPLLQRRQ RLQLGRWQGW HSSERALERV 

       430        440        450        460        470        480 
PSMELGRLEI PAELAVMLKT AESHRDALAG SITECLPPEV PARPSLTLPA DIDLFPFSSF 

       490        500        510        520        530        540 
VAIGFQEPSL PRPGQPLAKP LTQLDGDNPQ RALDINKVML RLLGDGSLES WQRQIMGAYL 

       550        560        570        580        590        600 
VRQGQCWPGL RNELFSQLVA QLWQNPDEQQ SQRGWALMAV LLSAFPPLPV LQKPLLKFVS 

       610        620        630        640        650        660 
DQAPRGMAAL CQHKLLGALE QSQLASGATR AHPPTQLEWL AGWRRGRMAL DVFTFSEECY 

       670        680        690        700        710        720 
SAEVESWTTG EQLAGWILQS RGLEAPPRGW SVSLHSRDAW QDLAGCDFVL DLISQTEDLG 

       730        740        750        760        770        780 
DPARPRSYPI TPLGSAEAIP LAPGIQAPSL PPGPPPGPAP TLPSRDHTGE VQRSGSLDGF 

       790        800        810        820        830        840 
LDQIFQPVIS SGLSDLEQSW ALSSRMKGGG AIGPTQQGYP MVYPGMIQMP AYQPGMVPAP 

       850        860        870        880        890        900 
MPMMPAMGTV PAMPAMVVPP QPPLPSLDAG QLAVQQQNFI QQQALILAQQ MTAQAMSLSL 

       910        920        930        940        950        960 
EQQMQQRQQQ ARASEAASQA SPSAVTSKPR KPPTPPEKPQ RDLGSEGGCL RETSEEAEDR 

       970        980        990       1000       1010       1020 
PYQPKSFQQK RNYFQRMGQP QITVRTMKPP AKVHIPQGEA QEEEEEEEEE EEQEEQEVET 

      1030       1040       1050       1060       1070       1080 
RAVPSPPPPP IVKKPLKQGG AKAPKEAEAE PAKETAAKGH GQGPAQGRGT VVRSSDSKPK 

      1090       1100       1110       1120       1130       1140 
RPQPSREIGN IIRMYQSRPG PVPVPVQPSR PPKAFLRKID PKDEALAKLG INGAHSSPPM 

      1150       1160       1170       1180       1190       1200 
LSPSPGKGPP PAVAPRPKAP LQLGPSSSIK EKQGPLLDLF GQKLPIAHTP PPPPAPPLPL 

      1210       1220       1230       1240       1250       1260 
PEDPGTLSAE RRCLTQPVED QGVSTQLLAP SGSVCFSYTG TPWKLFLRKE VFYPRENFSH 

      1270       1280       1290       1300       1310       1320 
PYYLRLLCEQ ILRDTFSESC IRISQNERRK MKDLLGGLEV DLDSLTTTED SVKKRIVVAA 

      1330       1340       1350       1360       1370       1380 
RDNWANYFSR FFPVSGESGS DVQLLAVSHR GLRLLKVTQG PGLRPDQLKI LCSYSFAEVL 

      1390       1400       1410       1420       1430       1440 
GVECRGGSTL ELSLKSEQLV LHTARARAIE ALVELFLNEL KKDSGYVIAL RSYITDNCSL 

      1450       1460       1470       1480       1490       1500 
LSFHRGDLIK LLPVATLEPG WQFGSAGGRS GLFPADIVQP AAAPDFSFSK EQRSGWHKGQ 

      1510       1520       1530 
LSNGEPGLAR WDRASEVRKM GEGQAEARPA 

« Hide

References

« Hide 'large scale' references
[1]"Human myosin XVBP is a transcribed pseudogene."
Boger E.T., Sellers J.R., Friedman T.B.
J. Muscle Res. Cell Motil. 22:477-483(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], ALTERNATIVE SPLICING, LACK OF FUNCTIONAL MOTOR DOMAIN.
Tissue: Kidney and Stomach.
[2]"Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
Nagase T., Nakayama M., Nakajima D., Kikuno R., Ohara O.
DNA Res. 8:85-95(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[3]"A millennial myosin census."
Berg J.S., Powell B.C., Cheney R.E.
Mol. Biol. Cell 12:780-794(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION.
[4]"Solution structure of the SH3 domain of human KIAA1783 protein."
RIKEN structural genomics initiative (RSGI)
Submitted (OCT-2006) to the PDB data bank
Cited for: STRUCTURE BY NMR OF 1424-1495.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF418286 mRNA. No translation available.
AF418287 mRNA. No translation available.
AF418288 mRNA. No translation available.
AF418289 mRNA. No translation available.
AF418290 mRNA. No translation available.
AF418291 mRNA. No translation available.
AF418292 mRNA. No translation available.
AF418293 mRNA. No translation available.
AB058686 mRNA. Translation: BAB47412.1. Different initiation.
UniGeneHs.390817.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2DLPNMR-A1424-1495[»]
ProteinModelPortalQ96JP2.
SMRQ96JP2. Positions 90-449, 1242-1495.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ96JP2. 2 interactions.
MINTMINT-5001895.
STRING9606.ENSP00000293201.

PTM databases

PhosphoSiteQ96JP2.

Polymorphism databases

DMDM150384690.

Proteomic databases

PaxDbQ96JP2.
PRIDEQ96JP2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

UCSCuc002jon.1. human.

Organism-specific databases

GeneCardsGC17P073586.
HGNCHGNC:14083. MYO15B.
HPAHPA023377.
neXtProtNX_Q96JP2.
HUGESearch...
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5022.
HOGENOMHOG000169369.
HOVERGENHBG108162.
InParanoidQ96JP2.
PhylomeDBQ96JP2.

Gene expression databases

ArrayExpressQ96JP2.
BgeeQ96JP2.
GenevestigatorQ96JP2.

Family and domain databases

InterProIPR000048. IQ_motif_EF-hand-BS.
IPR001609. Myosin_head_motor_dom.
IPR000857. MyTH4_dom.
IPR027417. P-loop_NTPase.
IPR011511. SH3_2.
IPR001452. SH3_domain.
[Graphical view]
PfamPF00063. Myosin_head. 1 hit.
PF00784. MyTH4. 1 hit.
PF07653. SH3_2. 1 hit.
[Graphical view]
SMARTSM00015. IQ. 1 hit.
SM00242. MYSc. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMSSF50044. SSF50044. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEPS50096. IQ. 1 hit.
PS51016. MYTH4. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSMYO15B. human.
EvolutionaryTraceQ96JP2.

Entry information

Entry nameMY15B_HUMAN
AccessionPrimary (citable) accession number: Q96JP2
Entry history
Integrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: June 26, 2007
Last modified: April 16, 2014
This is version 93 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

Human chromosome 17

Human chromosome 17: entries, gene names and cross-references to MIM