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Protein

Protein fem-1 homolog C

Gene

FEM1C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Probable component of an E3 ubiquitin-protein ligase complex, in which it may act as a substrate recognition subunit.By similarity

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ubl conjugation pathway

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein fem-1 homolog C
Short name:
FEM1c
Alternative name(s):
FEM1-gamma
Gene namesi
Name:FEM1C
Synonyms:KIAA1785
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:16933. FEM1C.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134891999.

Polymorphism and mutation databases

BioMutaiFEM1C.
DMDMi74751963.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 617617Protein fem-1 homolog CPRO_0000324536Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineCombined sources

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ96JP0.
MaxQBiQ96JP0.
PaxDbiQ96JP0.
PRIDEiQ96JP0.

PTM databases

iPTMnetiQ96JP0.
PhosphoSiteiQ96JP0.

Expressioni

Tissue specificityi

Widely expressed. Highly expressed in kidney, cardiac tissue, skeletal muscle and testis. Expressed at lower levels in other tissues, including cartilage.2 Publications

Gene expression databases

BgeeiQ96JP0.
CleanExiHS_FEM1C.
GenevisibleiQ96JP0. HS.

Organism-specific databases

HPAiHPA059919.

Interactioni

Subunit structurei

Component of some E3 ubiquitin-protein ligase complex.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
LZTS2Q9BRK43EBI-2515330,EBI-741037
PNMA1Q8ND903EBI-2515330,EBI-302345
RPGRIP1Q96KN73EBI-2515330,EBI-1050213

Protein-protein interaction databases

BioGridi121256. 10 interactions.
IntActiQ96JP0. 5 interactions.
STRINGi9606.ENSP00000274457.

Structurei

3D structure databases

ProteinModelPortaliQ96JP0.
SMRiQ96JP0. Positions 1-567.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati2 – 3130ANK 1Add
BLAST
Repeati40 – 7031ANK 2Add
BLAST
Repeati82 – 11130ANK 3Add
BLAST
Repeati115 – 14430ANK 4Add
BLAST
Repeati148 – 17730ANK 5Add
BLAST
Repeati181 – 21030ANK 6Add
BLAST
Repeati213 – 24230ANK 7Add
BLAST
Repeati245 – 27935TPR 1Add
BLAST
Repeati338 – 37134TPR 2Add
BLAST
Repeati481 – 52343ANK 8Add
BLAST
Repeati527 – 55630ANK 9Add
BLAST

Sequence similaritiesi

Belongs to the fem-1 family.Curated
Contains 9 ANK repeats.PROSITE-ProRule annotation
Contains 2 TPR repeats.Curated

Keywords - Domaini

ANK repeat, Repeat, TPR repeat

Phylogenomic databases

eggNOGiKOG0508. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00840000129781.
HOGENOMiHOG000008180.
HOVERGENiHBG057774.
InParanoidiQ96JP0.
OMAiDRNTTCV.
OrthoDBiEOG7T4MJT.
PhylomeDBiQ96JP0.
TreeFamiTF351376.

Family and domain databases

Gene3Di1.25.40.20. 5 hits.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view]
PfamiPF12796. Ank_2. 3 hits.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
SMARTiSM00248. ANK. 9 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 3 hits.
PROSITEiPS50297. ANK_REP_REGION. 2 hits.
PS50088. ANK_REPEAT. 7 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96JP0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDLKTAVFNA ARDGKLRLLT KLLASKSKEE VSSLISEKTN GATPLLMAAR
60 70 80 90 100
YGHLDMVEFL LEQCSASIEV GGSVNFDGET IEGAPPLWAA SAAGHLKVVQ
110 120 130 140 150
SLLNHGASVN NTTLTNSTPL RAACFDGHLE IVKYLVEHKA DLEVSNRHGH
160 170 180 190 200
TCLMISCYKG HKEIAQYLLE KGADVNRKSV KGNTALHDCA ESGSLDIMKM
210 220 230 240 250
LLMYCAKMEK DGYGMTPLLS ASVTGHTNIV DFLTHHAQTS KTERINALEL
260 270 280 290 300
LGATFVDKKR DLLGALKYWK KAMNMRYSDR TNIISKPVPQ TLIMAYDYAK
310 320 330 340 350
EVNSAEELEG LIADPDEMRM QALLIRERIL GPSHPDTSYY IRYRGAVYAD
360 370 380 390 400
SGNFKRCINL WKYALDMQQS NLDPLSPMTA SSLLSFAELF SFMLQDRAKG
410 420 430 440 450
LLGTTVTFDD LMGILCKSVL EIERAIKQTQ CPADPLQLNK ALSIILHLIC
460 470 480 490 500
LLEKVPCTLE QDHFKKQTIY RFLKLHPRGK NNFSPLHLAV DKNTTCVGRY
510 520 530 540 550
PVCKFPSLQV TAILIECGAD VNVRDSDDNS PLHIAALNNH PDIMNLLIKS
560 570 580 590 600
GAHFDATNLH KQTASDLLDE KEIAKNLIQP INHTTLQCLA ARVIVNHRIY
610
YKGHIPEKLE TFVSLHR
Length:617
Mass (Da):68,673
Last modified:December 1, 2001 - v1
Checksum:i6218B3963C486369
GO

Sequence cautioni

The sequence BAB15096.1 differs from that shown. Reason: Erroneous initiation. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti434 – 4341D → N in a breast cancer sample; somatic mutation. 1 Publication
VAR_039810
Natural varianti462 – 4621D → N in a breast cancer sample; somatic mutation. 1 Publication
VAR_039811

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF391093 mRNA. Translation: AAL37627.1.
AY249188 mRNA. Translation: AAO64429.1.
AB058688 mRNA. Translation: BAB47414.1.
AK025265 mRNA. Translation: BAB15096.1. Different initiation.
AK315803 mRNA. Translation: BAG38144.1.
CH471086 Genomic DNA. Translation: EAW48963.1.
BC028369 mRNA. Translation: AAH28369.1.
AL365409 mRNA. Translation: CAB96953.1.
AL365415 mRNA. Translation: CAB96957.1.
AL831817 mRNA. Translation: CAD38531.1.
CCDSiCCDS4118.1.
RefSeqiNP_064562.1. NM_020177.2.
XP_005272092.1. XM_005272035.3.
UniGeneiHs.47367.

Genome annotation databases

EnsembliENST00000274457; ENSP00000274457; ENSG00000145780.
GeneIDi56929.
KEGGihsa:56929.
UCSCiuc003krb.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF391093 mRNA. Translation: AAL37627.1.
AY249188 mRNA. Translation: AAO64429.1.
AB058688 mRNA. Translation: BAB47414.1.
AK025265 mRNA. Translation: BAB15096.1. Different initiation.
AK315803 mRNA. Translation: BAG38144.1.
CH471086 Genomic DNA. Translation: EAW48963.1.
BC028369 mRNA. Translation: AAH28369.1.
AL365409 mRNA. Translation: CAB96953.1.
AL365415 mRNA. Translation: CAB96957.1.
AL831817 mRNA. Translation: CAD38531.1.
CCDSiCCDS4118.1.
RefSeqiNP_064562.1. NM_020177.2.
XP_005272092.1. XM_005272035.3.
UniGeneiHs.47367.

3D structure databases

ProteinModelPortaliQ96JP0.
SMRiQ96JP0. Positions 1-567.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121256. 10 interactions.
IntActiQ96JP0. 5 interactions.
STRINGi9606.ENSP00000274457.

PTM databases

iPTMnetiQ96JP0.
PhosphoSiteiQ96JP0.

Polymorphism and mutation databases

BioMutaiFEM1C.
DMDMi74751963.

Proteomic databases

EPDiQ96JP0.
MaxQBiQ96JP0.
PaxDbiQ96JP0.
PRIDEiQ96JP0.

Protocols and materials databases

DNASUi56929.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000274457; ENSP00000274457; ENSG00000145780.
GeneIDi56929.
KEGGihsa:56929.
UCSCiuc003krb.2. human.

Organism-specific databases

CTDi56929.
GeneCardsiFEM1C.
HGNCiHGNC:16933. FEM1C.
HPAiHPA059919.
MIMi608767. gene.
neXtProtiNX_Q96JP0.
PharmGKBiPA134891999.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0508. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00840000129781.
HOGENOMiHOG000008180.
HOVERGENiHBG057774.
InParanoidiQ96JP0.
OMAiDRNTTCV.
OrthoDBiEOG7T4MJT.
PhylomeDBiQ96JP0.
TreeFamiTF351376.

Enzyme and pathway databases

UniPathwayiUPA00143.

Miscellaneous databases

ChiTaRSiFEM1C. human.
GenomeRNAii56929.
PROiQ96JP0.
SOURCEiSearch...

Gene expression databases

BgeeiQ96JP0.
CleanExiHS_FEM1C.
GenevisibleiQ96JP0. HS.

Family and domain databases

Gene3Di1.25.40.20. 5 hits.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view]
PfamiPF12796. Ank_2. 3 hits.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
SMARTiSM00248. ANK. 9 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 3 hits.
PROSITEiPS50297. ANK_REP_REGION. 2 hits.
PS50088. ANK_REPEAT. 7 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of human FEM1A, the ortholog of a C. elegans sex-differentiation gene."
    Krakow D., Sebald E., King L.M., Cohn D.H.
    Gene 279:213-219(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Tissue: Cartilage.
  2. "The Fem1c genes: conserved members of the Fem1 gene family in vertebrates."
    Ventura-Holman T., Lu D., Si X., Izevbigie E.B., Maher J.F.
    Gene 314:133-139(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Tissue: Testis.
  3. "Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Nakayama M., Nakajima D., Kikuno R., Ohara O.
    DNA Res. 8:85-95(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Colon and Trachea.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  7. The European IMAGE consortium
    Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-271 AND 301-617.
  8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 279-617.
    Tissue: Skeletal muscle.
  9. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  10. Cited for: VARIANTS [LARGE SCALE ANALYSIS] ASN-434 AND ASN-462.

Entry informationi

Entry nameiFEM1C_HUMAN
AccessioniPrimary (citable) accession number: Q96JP0
Secondary accession number(s): B2RE47
, Q8N3V8, Q9H704, Q9NPL6, Q9NPL9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: December 1, 2001
Last modified: June 8, 2016
This is version 126 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Was initially thought to be the ortholog of mouse FEM1A.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.