ID CC136_HUMAN Reviewed; 1154 AA. AC Q96JN2; A4D1K1; A7MCY7; A8MYA7; Q6ZVK7; Q9H8M3; Q9UFE1; DT 11-SEP-2007, integrated into UniProtKB/Swiss-Prot. DT 18-MAY-2010, sequence version 3. DT 24-JAN-2024, entry version 141. DE RecName: Full=Coiled-coil domain-containing protein 136; DE AltName: Full=Nasopharyngeal carcinoma-associated gene 6 protein; GN Name=CCDC136; Synonyms=KIAA1793; ORFNames=NAG6; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANT GLU-1049. RC TISSUE=Brain; RX PubMed=11347906; DOI=10.1093/dnares/8.2.85; RA Nagase T., Nakayama M., Nakajima D., Kikuno R., Ohara O.; RT "Prediction of the coding sequences of unidentified human genes. XX. The RT complete sequences of 100 new cDNA clones from brain which code for large RT proteins in vitro."; RL DNA Res. 8:85-95(2001). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), AND NUCLEOTIDE SEQUENCE RP [LARGE SCALE MRNA] OF 410-1154 (ISOFORM 2). RC TISSUE=Cerebellum, and Placenta; RX PubMed=14702039; DOI=10.1038/ng1285; RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., RA Isogai T., Sugano S.; RT "Complete sequencing and characterization of 21,243 full-length human RT cDNAs."; RL Nat. Genet. 36:40-45(2004). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=12853948; DOI=10.1038/nature01782; RA Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., RA Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., RA Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., RA Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H., Sun H., RA Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., RA Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., RA Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., RA Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., RA Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., RA Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., RA Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., RA Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., RA Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., RA Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., RA Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., RA Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., RA Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., RA McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., RA Wilson R.K.; RT "The DNA sequence of human chromosome 7."; RL Nature 424:157-164(2003). RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANT GLU-1049. RX PubMed=12690205; DOI=10.1126/science.1083423; RA Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., RA Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., RA Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., RA Kanematsu E., Gentles S., Christopoulos C.C., Choufani S., Kwasnicka D., RA Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., RA Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., RA Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., RA Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., RA Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., RA Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., RA Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., RA Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., RA Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., RA Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., RA Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., RA Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., RA Adams M.D., Tsui L.-C.; RT "Human chromosome 7: DNA sequence and biology."; RL Science 300:767-772(2003). RN [5] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANT GLU-1049. RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., RA Hunkapiller M.W., Myers E.W., Venter J.C.; RL Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases. RN [6] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANT GLU-1049. RC TISSUE=Brain; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [7] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 125-1154 (ISOFORM 4), AND VARIANT RP GLU-1049. RC TISSUE=Testis; RX PubMed=17974005; DOI=10.1186/1471-2164-8-399; RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., RA Wiemann S., Schupp I.; RT "The full-ORF clone resource of the German cDNA consortium."; RL BMC Genomics 8:399-399(2007). RN [8] RP NUCLEOTIDE SEQUENCE [MRNA] OF 1128-1154 (ISOFORM 4), AND TISSUE RP SPECIFICITY. RC TISSUE=Nasopharyngeal carcinoma; RX PubMed=15112360; DOI=10.3748/wjg.v10.i9.1361; RA Zhang X.-M., Sheng S.-R., Wang X.-Y., Bin L.-H., Wang J.-R., Li G.-Y.; RT "Expression of tumor related gene NAG6 in gastric cancer and restriction RT fragment length polymorphism analysis."; RL World J. Gastroenterol. 10:1361-1364(2004). RN [9] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-52, AND IDENTIFICATION BY RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Erythroleukemia; RX PubMed=23186163; DOI=10.1021/pr300630k; RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J., RA Mohammed S.; RT "Toward a comprehensive characterization of a human cancer cell RT phosphoproteome."; RL J. Proteome Res. 12:260-271(2013). CC -!- FUNCTION: May play a role in acrosome formation in spermatogenesis and CC in fertilization. {ECO:0000250|UniProtKB:Q3TVA9}. CC -!- INTERACTION: CC Q96JN2-2; Q9ULW3: ABT1; NbExp=3; IntAct=EBI-10171416, EBI-2602396; CC Q96JN2-2; P29972: AQP1; NbExp=3; IntAct=EBI-10171416, EBI-745213; CC Q96JN2-2; Q9H672: ASB7; NbExp=4; IntAct=EBI-10171416, EBI-3916346; CC Q96JN2-2; P48047: ATP5PO; NbExp=3; IntAct=EBI-10171416, EBI-355815; CC Q96JN2-2; A0AVN2: BARD1; NbExp=3; IntAct=EBI-10171416, EBI-9977322; CC Q96JN2-2; Q9UL45: BLOC1S6; NbExp=3; IntAct=EBI-10171416, EBI-465781; CC Q96JN2-2; Q13895: BYSL; NbExp=5; IntAct=EBI-10171416, EBI-358049; CC Q96JN2-2; Q8TAB5: C1orf216; NbExp=3; IntAct=EBI-10171416, EBI-747505; CC Q96JN2-2; Q9HC52: CBX8; NbExp=3; IntAct=EBI-10171416, EBI-712912; CC Q96JN2-2; Q8IYE0-2: CCDC146; NbExp=3; IntAct=EBI-10171416, EBI-10247802; CC Q96JN2-2; Q8TD31-3: CCHCR1; NbExp=3; IntAct=EBI-10171416, EBI-10175300; CC Q96JN2-2; O14519: CDK2AP1; NbExp=3; IntAct=EBI-10171416, EBI-1052532; CC Q96JN2-2; Q8IYX8: CEP57L1; NbExp=3; IntAct=EBI-10171416, EBI-1104570; CC Q96JN2-2; Q8IYX8-2: CEP57L1; NbExp=3; IntAct=EBI-10171416, EBI-10181988; CC Q96JN2-2; Q2TBE0: CWF19L2; NbExp=3; IntAct=EBI-10171416, EBI-5453285; CC Q96JN2-2; Q9H0I2: ENKD1; NbExp=3; IntAct=EBI-10171416, EBI-744099; CC Q96JN2-2; O95990-3: FAM107A; NbExp=3; IntAct=EBI-10171416, EBI-10192902; CC Q96JN2-2; Q3B820: FAM161A; NbExp=3; IntAct=EBI-10171416, EBI-719941; CC Q96JN2-2; Q96CS2: HAUS1; NbExp=3; IntAct=EBI-10171416, EBI-2514791; CC Q96JN2-2; P56524: HDAC4; NbExp=3; IntAct=EBI-10171416, EBI-308629; CC Q96JN2-2; Q9NP66: HMG20A; NbExp=3; IntAct=EBI-10171416, EBI-740641; CC Q96JN2-2; Q9P0W2: HMG20B; NbExp=3; IntAct=EBI-10171416, EBI-713401; CC Q96JN2-2; Q8N9B5-2: JMY; NbExp=3; IntAct=EBI-10171416, EBI-10268138; CC Q96JN2-2; Q7Z3B3: KANSL1; NbExp=3; IntAct=EBI-10171416, EBI-740244; CC Q96JN2-2; Q92993: KAT5; NbExp=3; IntAct=EBI-10171416, EBI-399080; CC Q96JN2-2; Q9BVG8: KIFC3; NbExp=3; IntAct=EBI-10171416, EBI-2125614; CC Q96JN2-2; Q96BZ8: LENG1; NbExp=3; IntAct=EBI-10171416, EBI-726510; CC Q96JN2-2; O15481: MAGEB4; NbExp=3; IntAct=EBI-10171416, EBI-751857; CC Q96JN2-2; P00540: MOS; NbExp=3; IntAct=EBI-10171416, EBI-1757866; CC Q96JN2-2; Q96HC4: PDLIM5; NbExp=3; IntAct=EBI-10171416, EBI-751267; CC Q96JN2-2; Q6NYC8: PPP1R18; NbExp=3; IntAct=EBI-10171416, EBI-2557469; CC Q96JN2-2; Q8WWY3: PRPF31; NbExp=3; IntAct=EBI-10171416, EBI-1567797; CC Q96JN2-2; O00233: PSMD9; NbExp=3; IntAct=EBI-10171416, EBI-750973; CC Q96JN2-2; Q14088: RAB33A; NbExp=3; IntAct=EBI-10171416, EBI-744685; CC Q96JN2-2; Q9NUL5: SHFL; NbExp=3; IntAct=EBI-10171416, EBI-10313866; CC Q96JN2-2; Q969G3: SMARCE1; NbExp=3; IntAct=EBI-10171416, EBI-455078; CC Q96JN2-2; Q05BL0: TBRG1; NbExp=3; IntAct=EBI-10171416, EBI-10223693; CC Q96JN2-2; Q15560: TCEA2; NbExp=3; IntAct=EBI-10171416, EBI-710310; CC Q96JN2-2; P13805: TNNT1; NbExp=3; IntAct=EBI-10171416, EBI-726527; CC Q96JN2-2; P40222: TXLNA; NbExp=5; IntAct=EBI-10171416, EBI-359793; CC Q96JN2-2; O75604: USP2; NbExp=3; IntAct=EBI-10171416, EBI-743272; CC Q96JN2-2; Q53FD0: ZC2HC1C; NbExp=3; IntAct=EBI-10171416, EBI-740767; CC Q96JN2-2; P17024: ZNF20; NbExp=3; IntAct=EBI-10171416, EBI-717634; CC Q96JN2-2; Q9UIE0: ZNF230; NbExp=3; IntAct=EBI-10171416, EBI-1105361; CC Q96JN2-2; P15622-3: ZNF250; NbExp=3; IntAct=EBI-10171416, EBI-10177272; CC Q96JN2-2; Q8TAU3: ZNF417; NbExp=3; IntAct=EBI-10171416, EBI-740727; CC Q96JN2-2; Q9ULM2: ZNF490; NbExp=3; IntAct=EBI-10171416, EBI-1105370; CC Q96JN2-2; Q8TBZ8: ZNF564; NbExp=3; IntAct=EBI-10171416, EBI-10273713; CC Q96JN2-2; Q7Z3I7: ZNF572; NbExp=6; IntAct=EBI-10171416, EBI-10172590; CC Q96JN2-2; Q9P0T4: ZNF581; NbExp=3; IntAct=EBI-10171416, EBI-745520; CC Q96JN2-2; Q96SQ5: ZNF587; NbExp=3; IntAct=EBI-10171416, EBI-6427977; CC Q96JN2-2; Q16670: ZSCAN26; NbExp=3; IntAct=EBI-10171416, EBI-3920053; CC Q96JN2-2; Q9H6F0; NbExp=3; IntAct=EBI-10171416, EBI-10307481; CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, acrosome CC membrane {ECO:0000250|UniProtKB:Q3TVA9}; Single-pass membrane protein CC {ECO:0000250|UniProtKB:Q3TVA9}. Note=Exclusively localized on a CC peripheral part of acrosome membrane (Golgi phase), localized on the CC equatorial segment of the acrosome (maturation phase). CC {ECO:0000250|UniProtKB:Q3TVA9}. CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=4; CC Name=1; CC IsoId=Q96JN2-1; Sequence=Displayed; CC Name=2; CC IsoId=Q96JN2-2; Sequence=VSP_027843, VSP_027844; CC Name=3; CC IsoId=Q96JN2-3; Sequence=VSP_027840, VSP_027841, VSP_027842; CC Name=4; CC IsoId=Q96JN2-4; Sequence=VSP_027845; CC -!- TISSUE SPECIFICITY: Expressed in gastric tissues. Down-regulated in CC gastric cancer. {ECO:0000269|PubMed:15112360}. CC -!- MISCELLANEOUS: Restriction fragment length polymorphisms (RFLPs) in CC gastric cancer showed loss of 5 kb fragment in comparison with the CC corresponding normal tissue. CC -!- SEQUENCE CAUTION: CC Sequence=AF156971; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305}; CC Sequence=BAB14590.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; CC Sequence=BAB47422.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305}; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AB058696; BAB47422.1; ALT_INIT; mRNA. DR EMBL; AK023500; BAB14590.1; ALT_INIT; mRNA. DR EMBL; AK124447; BAC85854.1; -; mRNA. DR EMBL; AC024952; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC025594; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CH236950; EAL24111.1; -; Genomic_DNA. DR EMBL; CH471070; EAW83682.1; -; Genomic_DNA. DR EMBL; CH471070; EAW83684.1; -; Genomic_DNA. DR EMBL; BC150331; AAI50332.1; -; mRNA. DR EMBL; BC152408; AAI52409.1; -; mRNA. DR EMBL; AL133027; CAB61359.1; -; mRNA. DR EMBL; AF156971; -; NOT_ANNOTATED_CDS; mRNA. DR CCDS; CCDS47704.1; -. [Q96JN2-1] DR CCDS; CCDS56510.1; -. [Q96JN2-3] DR PIR; T42701; T42701. DR RefSeq; NP_001188301.1; NM_001201372.1. [Q96JN2-3] DR RefSeq; NP_073579.4; NM_022742.4. [Q96JN2-1] DR RefSeq; XP_016868022.1; XM_017012533.1. DR AlphaFoldDB; Q96JN2; -. DR SMR; Q96JN2; -. DR BioGRID; 122267; 167. DR IntAct; Q96JN2; 81. DR MINT; Q96JN2; -. DR STRING; 9606.ENSP00000297788; -. DR iPTMnet; Q96JN2; -. DR PhosphoSitePlus; Q96JN2; -. DR BioMuta; CCDC136; -. DR DMDM; 296439415; -. DR EPD; Q96JN2; -. DR jPOST; Q96JN2; -. DR MassIVE; Q96JN2; -. DR MaxQB; Q96JN2; -. DR PaxDb; 9606-ENSP00000297788; -. DR PeptideAtlas; Q96JN2; -. DR ProteomicsDB; 76991; -. [Q96JN2-1] DR ProteomicsDB; 76992; -. [Q96JN2-2] DR ProteomicsDB; 76993; -. [Q96JN2-3] DR ProteomicsDB; 76994; -. [Q96JN2-4] DR Antibodypedia; 2414; 44 antibodies from 10 providers. DR DNASU; 64753; -. DR Ensembl; ENST00000297788.9; ENSP00000297788.4; ENSG00000128596.17. [Q96JN2-1] DR Ensembl; ENST00000378685.8; ENSP00000367956.4; ENSG00000128596.17. [Q96JN2-3] DR GeneID; 64753; -. DR KEGG; hsa:64753; -. DR MANE-Select; ENST00000297788.9; ENSP00000297788.4; NM_022742.5; NP_073579.5. DR UCSC; uc003vnu.3; human. [Q96JN2-1] DR AGR; HGNC:22225; -. DR CTD; 64753; -. DR DisGeNET; 64753; -. DR GeneCards; CCDC136; -. DR HGNC; HGNC:22225; CCDC136. DR HPA; ENSG00000128596; Group enriched (brain, retina, testis). DR MIM; 611902; gene. DR neXtProt; NX_Q96JN2; -. DR OpenTargets; ENSG00000128596; -. DR PharmGKB; PA162381381; -. DR VEuPathDB; HostDB:ENSG00000128596; -. DR eggNOG; ENOG502RZUE; Eukaryota. DR GeneTree; ENSGT00940000159122; -. DR HOGENOM; CLU_007247_0_0_1; -. DR InParanoid; Q96JN2; -. DR OMA; NEKELMC; -. DR OrthoDB; 5361839at2759; -. DR PhylomeDB; Q96JN2; -. DR TreeFam; TF350490; -. DR PathwayCommons; Q96JN2; -. DR SignaLink; Q96JN2; -. DR BioGRID-ORCS; 64753; 17 hits in 1159 CRISPR screens. DR ChiTaRS; CCDC136; human. DR GenomeRNAi; 64753; -. DR Pharos; Q96JN2; Tbio. DR PRO; PR:Q96JN2; -. DR Proteomes; UP000005640; Chromosome 7. DR RNAct; Q96JN2; Protein. DR Bgee; ENSG00000128596; Expressed in sperm and 149 other cell types or tissues. DR ExpressionAtlas; Q96JN2; baseline and differential. DR GO; GO:0002080; C:acrosomal membrane; ISS:UniProtKB. DR GO; GO:0001675; P:acrosome assembly; ISS:UniProtKB. DR GO; GO:0007338; P:single fertilization; ISS:UniProtKB. DR GO; GO:0007283; P:spermatogenesis; ISS:UniProtKB. DR Gene3D; 1.10.287.1490; -; 1. DR PANTHER; PTHR15715; CENTROSOMAL PROTEIN OF 170 KDA; 1. DR PANTHER; PTHR15715:SF26; COILED-COIL DOMAIN-CONTAINING PROTEIN 136; 1. DR Genevisible; Q96JN2; HS. PE 1: Evidence at protein level; KW Alternative splicing; Coiled coil; Cytoplasmic vesicle; Differentiation; KW Fertilization; Membrane; Phosphoprotein; Reference proteome; KW Spermatogenesis; Transmembrane; Transmembrane helix. FT CHAIN 1..1154 FT /note="Coiled-coil domain-containing protein 136" FT /id="PRO_0000300639" FT TRANSMEM 1130..1150 FT /note="Helical" FT /evidence="ECO:0000255" FT REGION 1..48 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 1031..1131 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COILED 696..733 FT /evidence="ECO:0000255" FT COILED 859..974 FT /evidence="ECO:0000255" FT COMPBIAS 11..32 FT /note="Acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 1031..1071 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 1072..1106 FT /note="Acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 1107..1126 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT MOD_RES 52 FT /note="Phosphoserine" FT /evidence="ECO:0007744|PubMed:23186163" FT VAR_SEQ 1 FT /note="M -> MEAGAGAGAGAAGWSCPGPGPTVTTLGSYEASEGCERKKGQRWGSLE FT RRGM (in isoform 3)" FT /evidence="ECO:0000303|PubMed:14702039" FT /id="VSP_027840" FT VAR_SEQ 212..223 FT /note="Missing (in isoform 3)" FT /evidence="ECO:0000303|PubMed:14702039" FT /id="VSP_027841" FT VAR_SEQ 364..1121 FT /note="Missing (in isoform 3)" FT /evidence="ECO:0000303|PubMed:14702039" FT /id="VSP_027842" FT VAR_SEQ 922..957 FT /note="IKELQTKLRELQLQYQASMDEQGRLLVVQEQLEGQL -> NMFGLWKPMVFL FT AIAAVALYVLPNMRQQESEFCLME (in isoform 2)" FT /evidence="ECO:0000303|PubMed:14702039" FT /id="VSP_027843" FT VAR_SEQ 958..1154 FT /note="Missing (in isoform 2)" FT /evidence="ECO:0000303|PubMed:14702039" FT /id="VSP_027844" FT VAR_SEQ 1122..1154 FT /note="SSPTPNPPIFSLPLVGLVVISALLWCWWAETSS -> NMFGLWKPMVFLAIA FT AVALYVLPNMRQQESEFCLME (in isoform 4)" FT /evidence="ECO:0000303|PubMed:15112360, FT ECO:0000303|PubMed:17974005" FT /id="VSP_027845" FT VARIANT 218 FT /note="D -> H (in dbSNP:rs3816887)" FT /id="VAR_034880" FT VARIANT 1049 FT /note="Q -> E (in dbSNP:rs4728137)" FT /evidence="ECO:0000269|PubMed:11347906, FT ECO:0000269|PubMed:12690205, ECO:0000269|PubMed:15489334, FT ECO:0000269|PubMed:17974005, ECO:0000269|Ref.5" FT /id="VAR_034881" FT CONFLICT 263..264 FT /note="QR -> HG (in Ref. 7; CAB61359)" FT /evidence="ECO:0000305" FT CONFLICT 490 FT /note="A -> V (in Ref. 2; BAB14590)" FT /evidence="ECO:0000305" SQ SEQUENCE 1154 AA; 134045 MW; FBB50829AB97E425 CRC64; MQAMEGEVLL PALYEEEEEE EEEEEEVEEE EEQVQKGGSV GSLSVNKHRG LSLTETELEE LRAQVLQLVA ELEETRELAG QHEDDSLELQ GLLEDERLAS AQQAEVFTKQ IQQLQGELRS LREEISLLEH EKESELKEIE QELHLAQAEI QSLRQAAEDS ATEHESDIAS LQEDLCRMQN ELEDMERIRG DYEMEIASLR AEMEMKSSEP SGSLGLSDYS GLQEELQELR ERYHFLNEEY RALQESNSSL TGQLADLESE RTQRATERWL QSQTLSMTSA ESQTSEMDFL EPDPEMQLLR QQLRDAEEQM HGMKNKCQEL CCELEELQHH RQVSEEEQRR LQRELKCAQN EVLRFQTSHS VTQNEELKSR LCTLQKKYDT SQDEQNELLK MQLQLQTELR QLKVMKSTLV ENQSEKELLC RLQKLHLQHQ NVTCEKEKLL ERQQQLQEEL QCHEAELQHL RDTVASFKES NEKDTETHAQ LQEMKQLYQA SKDELERQKH MYDQLEQDLL LCQLELKELK ASHPIPEDKG KCANKCDTLL SRLTELQEKY KASQKEMGQL QMEQCELLED QRRMQEEQGQ LQEELHRLTL PLPKSGLLLK SQELLTKLED LCELQLLYQG MQEEQKKLIQ NQDCVLKEQL EIHEELRRFK ESHFQEVLEN PDDSKLAKSS KCNRNKQSKL LMEQMQALQV MYDAGQAKQE LLQQEQGRLL EERKRLQADL QLCLEEMQLL QVQSPSIKMS LESYGKSYGS MVPSNENCRK TYDTTVDDNE SYYKSYTSTQ TSSKSFLKSY DSSTSASEAY GKSYCTTSNS SITYKKSYGS TSSSDTCQKS FVSSCTDEEP AEPEDMERFE EMVVKVLIKL QAVQAMYQIS QEEHSQLQEQ MEKLLAKQKD LKEELDACER EFKECMECLE KPMAPQNDKN EIKELQTKLR ELQLQYQASM DEQGRLLVVQ EQLEGQLQCC QEELRQLREK RPSVVKEARG KNANKNMNKN ANGVKMKKVT KPCSDTSESD LETRKSLEVV LYYKASQRKL DGLAKEEEKK EEMEEEKKQV KEEAKEQCGD ELVAEPADPE EAKSTEDQEE NEEDKEEEEK EEDSEEEEDD ADSSLESPEE NNPLRLSESK KSSPTPNPPI FSLPLVGLVV ISALLWCWWA ETSS //