Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q96JN0 (LCOR_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 91. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ligand-dependent corepressor

Short name=LCoR
Alternative name(s):
Mblk1-related protein 2
Gene names
Name:LCOR
Synonyms:KIAA1795, MLR2
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length433 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May act as transcription activator that binds DNA elements with the sequence 5'-CCCTATCGATCGATCTCTACCT-3' By similarity. Repressor of ligand-dependent transcription activation by target nuclear receptors. Repressor of ligand-dependent transcription activation by ESR1, ESR2, NR3C1, PGR, RARA, RARB, RARG, RXRA and VDR. Ref.6

Subunit structure

Interacts with ESR1 and ESR2 in the presence of estradiol. Interacts with CTBP1, HDAC3 and HDAC6. Component of a large corepressor complex that contains about 20 proteins, including CTBP1, CTBP2, HDAC1 and HDAC2. Ref.6 Ref.7

Subcellular location

Nucleus Ref.6.

Tissue specificity

Ubiquitous. Ref.6

Sequence similarities

Contains 1 HTH psq-type DNA-binding domain.

Sequence caution

The sequence BAB47424.1 differs from that shown. Reason: Erroneous initiation.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q96JN0-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q96JN0-2)

The sequence of this isoform differs from the canonical sequence as follows:
     405-406: RS → SG
     407-433: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 433433Ligand-dependent corepressor
PRO_0000236807

Regions

Domain340 – 39253HTH psq-type
DNA binding368 – 38821H-T-H motif By similarity
Motif53 – 575Interaction with nuclear receptors
Motif339 – 3457Nuclear localization signal Potential

Amino acid modifications

Modified residue631Phosphoserine Ref.10
Modified residue2491Phosphoserine Ref.10

Natural variations

Alternative sequence405 – 4062RS → SG in isoform 2.
VSP_018585
Alternative sequence407 – 43327Missing in isoform 2.
VSP_018586

Experimental info

Mutagenesis56 – 572LL → AA: Loss of estradiol-dependent interaction with ESR1 and ESR2. Ref.6
Sequence conflict61Q → P in CAD91159. Ref.2
Sequence conflict3211S → P in CAD38921. Ref.2

Secondary structure

........ 433
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified May 30, 2006. Version 2.
Checksum: 5F934FE687417740

FASTA43347,007
        10         20         30         40         50         60 
MQRMIQQFAA EYTSKNSSTQ DPSQPNSTKN QSLPKASPVT TSPTAATTQN PVLSKLLMAD 

        70         80         90        100        110        120 
QDSPLDLTVR KSQSEPSEQD GVLDLSTKKS PCAGSTSLSH SPGCSSTQGN GRPGRPSQYR 

       130        140        150        160        170        180 
PDGLRSGDGV PPRSLQDGTR EGFGHSTSLK VPLARSLQIS EELLSRNQLS TAASLGPSGL 

       190        200        210        220        230        240 
QNHGQHLILS REASWAKPHY EFNLSRMKFR GNGALSNISD LPFLAENSAF PKMALQAKQD 

       250        260        270        280        290        300 
GKKDVSHSSP VDLKIPQVRG MDLSWESRTG DQYSYSSLVM GSQTESALSK KLRAILPKQS 

       310        320        330        340        350        360 
RKSMLDAGPD SWGSDAEQST SGQPYPTSDQ EGDPGSKQPR KKRGRYRQYN SEILEEAISV 

       370        380        390        400        410        420 
VMSGKMSVSK AQSIYGIPHS TLEYKVKERL GTLKNPPKKK MKLMRSEGPD VSVKIELDPQ 

       430 
GEAAQSANES KNE 

« Hide

Isoform 2 [UniParc].

Checksum: ACE760CF3CB1F2EF
Show »

FASTA40644,083

References

« Hide 'large scale' references
[1]"Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
Nagase T., Nakayama M., Nakajima D., Kikuno R., Ohara O.
DNA Res. 8:85-95(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Brain.
[2]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Bone marrow and Skeletal muscle.
[3]"The DNA sequence and comparative analysis of human chromosome 10."
Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J. expand/collapse author list , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Lung.
[6]"Ligand-dependent nuclear receptor corepressor LCoR functions by histone deacetylase-dependent and -independent mechanisms."
Fernandes I., Bastien Y., Wai T., Nygard K., Lin R., Cormier O., Lee H.S., Eng F., Bertos N.R., Pelletier N., Mader S., Han V.K.M., Yang X.-J., White J.H.
Mol. Cell 11:139-150(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, INTERACTION WITH CTBP1; ESR1; ESR2; HDAC3 AND HDAC6, SUBCELLULAR LOCATION, MUTAGENESIS OF 56-LEU-LEU-57, TISSUE SPECIFICITY.
[7]"Coordinated histone modifications mediated by a CtBP co-repressor complex."
Shi Y., Sawada J., Sui G., Affar E.B., Whetstine J.R., Lan F., Ogawa H., Luke M.P.-S., Nakatani Y., Shi Y.
Nature 422:735-738(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION IN A COREPRESSOR COMPLEX, IDENTIFICATION BY MASS SPECTROMETRY.
[8]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[9]"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[10]"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-63 AND SER-249, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[11]"Solution structures of the HTH domain of human LCOR protein."
RIKEN structural genomics initiative (RSGI)
Submitted (NOV-2005) to the PDB data bank
Cited for: STRUCTURE BY NMR OF 343-405.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB058698 mRNA. Translation: BAB47424.1. Different initiation.
AL834245 mRNA. Translation: CAD38921.2.
AL832106 mRNA. Translation: CAD91159.1.
AL832044 mRNA. Translation: CAD91160.1.
AL442123 Genomic DNA. Translation: CAH70915.1.
CH471066 Genomic DNA. Translation: EAW49963.1.
CH471066 Genomic DNA. Translation: EAW49965.1.
CH471066 Genomic DNA. Translation: EAW49966.1.
BC053359 mRNA. Translation: AAH53359.1.
CCDSCCDS53561.1. [Q96JN0-2]
CCDS7451.1. [Q96JN0-1]
RefSeqNP_001164236.1. NM_001170765.1. [Q96JN0-1]
NP_001164237.1. NM_001170766.1. [Q96JN0-2]
NP_115816.2. NM_032440.3. [Q96JN0-1]
XP_006718097.1. XM_006718034.1. [Q96JN0-1]
UniGeneHs.745068.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2COBNMR-A343-405[»]
ProteinModelPortalQ96JN0.
SMRQ96JN0. Positions 346-405.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid124093. 10 interactions.
STRING9606.ENSP00000348298.

PTM databases

PhosphoSiteQ96JN0.

Polymorphism databases

DMDM108936028.

Proteomic databases

MaxQBQ96JN0.
PaxDbQ96JN0.
PRIDEQ96JN0.

Protocols and materials databases

DNASU84458.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000356016; ENSP00000348298; ENSG00000196233. [Q96JN0-1]
ENST00000371097; ENSP00000360138; ENSG00000196233. [Q96JN0-1]
ENST00000371103; ENSP00000360144; ENSG00000196233. [Q96JN0-1]
ENST00000540664; ENSP00000443431; ENSG00000196233. [Q96JN0-2]
GeneID84458.
KEGGhsa:84458.
UCSCuc001kmr.3. human. [Q96JN0-2]
uc001kms.2. human. [Q96JN0-1]

Organism-specific databases

CTD84458.
GeneCardsGC10P098583.
HGNCHGNC:29503. LCOR.
HPAHPA031428.
MIM607698. gene.
neXtProtNX_Q96JN0.
PharmGKBPA145148487.
HUGESearch...
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG309364.
HOVERGENHBG079596.
InParanoidQ96JN0.
OMAFQDCEPE.
OrthoDBEOG73RBBB.
PhylomeDBQ96JN0.
TreeFamTF319589.

Gene expression databases

BgeeQ96JN0.
CleanExHS_LCOR.
GenevestigatorQ96JN0.

Family and domain databases

InterProIPR009057. Homeodomain-like.
IPR007889. HTH_Psq.
[Graphical view]
PfamPF05225. HTH_psq. 1 hit.
[Graphical view]
SUPFAMSSF46689. SSF46689. 1 hit.
PROSITEPS50960. HTH_PSQ. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceQ96JN0.
GeneWikiLCOR.
GenomeRNAi84458.
NextBio74251.
PROQ96JN0.
SOURCESearch...

Entry information

Entry nameLCOR_HUMAN
AccessionPrimary (citable) accession number: Q96JN0
Secondary accession number(s): D3DR47 expand/collapse secondary AC list , Q5VW16, Q7Z723, Q86T32, Q86T33, Q8N3L6
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: May 30, 2006
Last modified: July 9, 2014
This is version 91 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 10

Human chromosome 10: entries, gene names and cross-references to MIM