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Protein

Ligand-dependent corepressor

Gene

LCOR

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May act as transcription activator that binds DNA elements with the sequence 5'-CCCTATCGATCGATCTCTACCT-3' (By similarity). Repressor of ligand-dependent transcription activation by target nuclear receptors. Repressor of ligand-dependent transcription activation by ESR1, ESR2, NR3C1, PGR, RARA, RARB, RARG, RXRA and VDR.By similarity1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi368 – 388H-T-H motifPROSITE-ProRule annotationAdd BLAST21

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator, Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciZFISH:G66-33218-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Ligand-dependent corepressor
Short name:
LCoR
Alternative name(s):
Mblk1-related protein 2
Gene namesi
Name:LCOR
Synonyms:KIAA1795, MLR2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:29503. LCOR.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi56 – 57LL → AA: Loss of estradiol-dependent interaction with ESR1 and ESR2. 1 Publication2

Organism-specific databases

DisGeNETi84458.
OpenTargetsiENSG00000196233.
PharmGKBiPA145148487.

Polymorphism and mutation databases

BioMutaiLCOR.
DMDMi108936028.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002368071 – 433Ligand-dependent corepressorAdd BLAST433

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei42PhosphoserineCombined sources1
Modified residuei63PhosphoserineCombined sources1
Modified residuei249PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ96JN0.
MaxQBiQ96JN0.
PaxDbiQ96JN0.
PeptideAtlasiQ96JN0.
PRIDEiQ96JN0.

PTM databases

iPTMnetiQ96JN0.
PhosphoSitePlusiQ96JN0.

Expressioni

Tissue specificityi

Ubiquitous.1 Publication

Gene expression databases

BgeeiENSG00000196233.
CleanExiHS_LCOR.
ExpressionAtlasiQ96JN0. baseline and differential.
GenevisibleiQ96JN0. HS.

Organism-specific databases

HPAiHPA031428.
HPA031429.

Interactioni

Subunit structurei

Interacts with ESR1 and ESR2 in the presence of estradiol. Interacts with CTBP1, HDAC3 and HDAC6. Component of a large corepressor complex that contains about 20 proteins, including CTBP1, CTBP2, HDAC1 and HDAC2.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
CTBP2P565454EBI-8833163,EBI-741533
CTBP2Q8IY443EBI-8833163,EBI-10171902
GOLGA2Q083793EBI-8833163,EBI-618309
TRAF1Q130773EBI-8833163,EBI-359224

Protein-protein interaction databases

BioGridi124093. 46 interactors.
IntActiQ96JN0. 32 interactors.
STRINGi9606.ENSP00000348298.

Structurei

Secondary structure

1433
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi351 – 362Combined sources12
Helixi368 – 375Combined sources8
Helixi379 – 389Combined sources11
Turni390 – 393Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2COBNMR-A343-405[»]
ProteinModelPortaliQ96JN0.
SMRiQ96JN0.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ96JN0.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini340 – 392HTH psq-typePROSITE-ProRule annotationAdd BLAST53

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi53 – 57Interaction with nuclear receptors5
Motifi339 – 345Nuclear localization signalSequence analysis7

Sequence similaritiesi

Contains 1 HTH psq-type DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG4565. Eukaryota.
ENOG4111GCI. LUCA.
GeneTreeiENSGT00530000064232.
HOVERGENiHBG079596.
InParanoidiQ96JN0.
OMAiHYEFNFS.
OrthoDBiEOG091G0N6A.
PhylomeDBiQ96JN0.
TreeFamiTF319589.

Family and domain databases

InterProiIPR009057. Homeodomain-like.
IPR007889. HTH_Psq.
[Graphical view]
PfamiPF05225. HTH_psq. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS50960. HTH_PSQ. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96JN0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MQRMIQQFAA EYTSKNSSTQ DPSQPNSTKN QSLPKASPVT TSPTAATTQN
60 70 80 90 100
PVLSKLLMAD QDSPLDLTVR KSQSEPSEQD GVLDLSTKKS PCAGSTSLSH
110 120 130 140 150
SPGCSSTQGN GRPGRPSQYR PDGLRSGDGV PPRSLQDGTR EGFGHSTSLK
160 170 180 190 200
VPLARSLQIS EELLSRNQLS TAASLGPSGL QNHGQHLILS REASWAKPHY
210 220 230 240 250
EFNLSRMKFR GNGALSNISD LPFLAENSAF PKMALQAKQD GKKDVSHSSP
260 270 280 290 300
VDLKIPQVRG MDLSWESRTG DQYSYSSLVM GSQTESALSK KLRAILPKQS
310 320 330 340 350
RKSMLDAGPD SWGSDAEQST SGQPYPTSDQ EGDPGSKQPR KKRGRYRQYN
360 370 380 390 400
SEILEEAISV VMSGKMSVSK AQSIYGIPHS TLEYKVKERL GTLKNPPKKK
410 420 430
MKLMRSEGPD VSVKIELDPQ GEAAQSANES KNE
Length:433
Mass (Da):47,007
Last modified:May 30, 2006 - v2
Checksum:i5F934FE687417740
GO
Isoform 2 (identifier: Q96JN0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     405-406: RS → SG
     407-433: Missing.

Show »
Length:406
Mass (Da):44,083
Checksum:iACE760CF3CB1F2EF
GO

Sequence cautioni

The sequence BAB47424 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti6Q → P in CAD91159 (PubMed:17974005).Curated1
Sequence conflicti321S → P in CAD38921 (PubMed:17974005).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_018585405 – 406RS → SG in isoform 2. 1 Publication2
Alternative sequenceiVSP_018586407 – 433Missing in isoform 2. 1 PublicationAdd BLAST27

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB058698 mRNA. Translation: BAB47424.1. Different initiation.
AL834245 mRNA. Translation: CAD38921.2.
AL832106 mRNA. Translation: CAD91159.1.
AL832044 mRNA. Translation: CAD91160.1.
AL442123 Genomic DNA. Translation: CAH70915.1.
CH471066 Genomic DNA. Translation: EAW49963.1.
CH471066 Genomic DNA. Translation: EAW49965.1.
CH471066 Genomic DNA. Translation: EAW49966.1.
BC053359 mRNA. Translation: AAH53359.1.
CCDSiCCDS53561.1. [Q96JN0-2]
CCDS7451.1. [Q96JN0-1]
RefSeqiNP_001164236.1. NM_001170765.1. [Q96JN0-1]
NP_001164237.1. NM_001170766.1. [Q96JN0-2]
NP_115816.2. NM_032440.3. [Q96JN0-1]
XP_016872275.1. XM_017016786.1. [Q96JN0-1]
XP_016872276.1. XM_017016787.1. [Q96JN0-1]
XP_016872277.1. XM_017016788.1. [Q96JN0-1]
UniGeneiHs.745068.

Genome annotation databases

EnsembliENST00000356016; ENSP00000348298; ENSG00000196233. [Q96JN0-1]
ENST00000371097; ENSP00000360138; ENSG00000196233. [Q96JN0-1]
ENST00000371103; ENSP00000360144; ENSG00000196233. [Q96JN0-1]
ENST00000540664; ENSP00000443431; ENSG00000196233. [Q96JN0-2]
GeneIDi84458.
KEGGihsa:84458.
UCSCiuc001kmr.4. human. [Q96JN0-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB058698 mRNA. Translation: BAB47424.1. Different initiation.
AL834245 mRNA. Translation: CAD38921.2.
AL832106 mRNA. Translation: CAD91159.1.
AL832044 mRNA. Translation: CAD91160.1.
AL442123 Genomic DNA. Translation: CAH70915.1.
CH471066 Genomic DNA. Translation: EAW49963.1.
CH471066 Genomic DNA. Translation: EAW49965.1.
CH471066 Genomic DNA. Translation: EAW49966.1.
BC053359 mRNA. Translation: AAH53359.1.
CCDSiCCDS53561.1. [Q96JN0-2]
CCDS7451.1. [Q96JN0-1]
RefSeqiNP_001164236.1. NM_001170765.1. [Q96JN0-1]
NP_001164237.1. NM_001170766.1. [Q96JN0-2]
NP_115816.2. NM_032440.3. [Q96JN0-1]
XP_016872275.1. XM_017016786.1. [Q96JN0-1]
XP_016872276.1. XM_017016787.1. [Q96JN0-1]
XP_016872277.1. XM_017016788.1. [Q96JN0-1]
UniGeneiHs.745068.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2COBNMR-A343-405[»]
ProteinModelPortaliQ96JN0.
SMRiQ96JN0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124093. 46 interactors.
IntActiQ96JN0. 32 interactors.
STRINGi9606.ENSP00000348298.

PTM databases

iPTMnetiQ96JN0.
PhosphoSitePlusiQ96JN0.

Polymorphism and mutation databases

BioMutaiLCOR.
DMDMi108936028.

Proteomic databases

EPDiQ96JN0.
MaxQBiQ96JN0.
PaxDbiQ96JN0.
PeptideAtlasiQ96JN0.
PRIDEiQ96JN0.

Protocols and materials databases

DNASUi84458.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000356016; ENSP00000348298; ENSG00000196233. [Q96JN0-1]
ENST00000371097; ENSP00000360138; ENSG00000196233. [Q96JN0-1]
ENST00000371103; ENSP00000360144; ENSG00000196233. [Q96JN0-1]
ENST00000540664; ENSP00000443431; ENSG00000196233. [Q96JN0-2]
GeneIDi84458.
KEGGihsa:84458.
UCSCiuc001kmr.4. human. [Q96JN0-1]

Organism-specific databases

CTDi84458.
DisGeNETi84458.
GeneCardsiLCOR.
HGNCiHGNC:29503. LCOR.
HPAiHPA031428.
HPA031429.
MIMi607698. gene.
neXtProtiNX_Q96JN0.
OpenTargetsiENSG00000196233.
PharmGKBiPA145148487.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4565. Eukaryota.
ENOG4111GCI. LUCA.
GeneTreeiENSGT00530000064232.
HOVERGENiHBG079596.
InParanoidiQ96JN0.
OMAiHYEFNFS.
OrthoDBiEOG091G0N6A.
PhylomeDBiQ96JN0.
TreeFamiTF319589.

Enzyme and pathway databases

BioCyciZFISH:G66-33218-MONOMER.

Miscellaneous databases

ChiTaRSiLCOR. human.
EvolutionaryTraceiQ96JN0.
GeneWikiiLCOR.
GenomeRNAii84458.
PROiQ96JN0.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000196233.
CleanExiHS_LCOR.
ExpressionAtlasiQ96JN0. baseline and differential.
GenevisibleiQ96JN0. HS.

Family and domain databases

InterProiIPR009057. Homeodomain-like.
IPR007889. HTH_Psq.
[Graphical view]
PfamiPF05225. HTH_psq. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS50960. HTH_PSQ. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLCOR_HUMAN
AccessioniPrimary (citable) accession number: Q96JN0
Secondary accession number(s): D3DR47
, Q5VW16, Q7Z723, Q86T32, Q86T33, Q8N3L6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: May 30, 2006
Last modified: November 30, 2016
This is version 113 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.