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Q96JN0

- LCOR_HUMAN

UniProt

Q96JN0 - LCOR_HUMAN

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Protein
Ligand-dependent corepressor
Gene
LCOR, KIAA1795, MLR2
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

May act as transcription activator that binds DNA elements with the sequence 5'-CCCTATCGATCGATCTCTACCT-3' By similarity. Repressor of ligand-dependent transcription activation by target nuclear receptors. Repressor of ligand-dependent transcription activation by ESR1, ESR2, NR3C1, PGR, RARA, RARB, RARG, RXRA and VDR.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi368 – 38821H-T-H motif By similarity
Add
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. sequence-specific DNA binding transcription factor activity Source: Ensembl

GO - Biological processi

  1. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
  2. transcription from RNA polymerase II promoter Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Activator, Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ligand-dependent corepressor
Short name:
LCoR
Alternative name(s):
Mblk1-related protein 2
Gene namesi
Name:LCOR
Synonyms:KIAA1795, MLR2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 10

Organism-specific databases

HGNCiHGNC:29503. LCOR.

Subcellular locationi

Nucleus 1 Publication

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi56 – 572LL → AA: Loss of estradiol-dependent interaction with ESR1 and ESR2. 1 Publication

Organism-specific databases

PharmGKBiPA145148487.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 433433Ligand-dependent corepressor
PRO_0000236807Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei63 – 631Phosphoserine1 Publication
Modified residuei249 – 2491Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ96JN0.
PaxDbiQ96JN0.
PRIDEiQ96JN0.

PTM databases

PhosphoSiteiQ96JN0.

Expressioni

Tissue specificityi

Ubiquitous.1 Publication

Gene expression databases

BgeeiQ96JN0.
CleanExiHS_LCOR.
GenevestigatoriQ96JN0.

Organism-specific databases

HPAiHPA031428.

Interactioni

Subunit structurei

Interacts with ESR1 and ESR2 in the presence of estradiol. Interacts with CTBP1, HDAC3 and HDAC6. Component of a large corepressor complex that contains about 20 proteins, including CTBP1, CTBP2, HDAC1 and HDAC2.2 Publications

Protein-protein interaction databases

BioGridi124093. 10 interactions.
STRINGi9606.ENSP00000348298.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi351 – 36212
Helixi368 – 3758
Helixi379 – 38911
Turni390 – 3934

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2COBNMR-A343-405[»]
ProteinModelPortaliQ96JN0.
SMRiQ96JN0. Positions 346-405.

Miscellaneous databases

EvolutionaryTraceiQ96JN0.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini340 – 39253HTH psq-type
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi53 – 575Interaction with nuclear receptors
Motifi339 – 3457Nuclear localization signal Reviewed prediction

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG309364.
HOVERGENiHBG079596.
InParanoidiQ96JN0.
OMAiFQDCEPE.
OrthoDBiEOG73RBBB.
PhylomeDBiQ96JN0.
TreeFamiTF319589.

Family and domain databases

InterProiIPR009057. Homeodomain-like.
IPR007889. HTH_Psq.
[Graphical view]
PfamiPF05225. HTH_psq. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS50960. HTH_PSQ. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q96JN0-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MQRMIQQFAA EYTSKNSSTQ DPSQPNSTKN QSLPKASPVT TSPTAATTQN    50
PVLSKLLMAD QDSPLDLTVR KSQSEPSEQD GVLDLSTKKS PCAGSTSLSH 100
SPGCSSTQGN GRPGRPSQYR PDGLRSGDGV PPRSLQDGTR EGFGHSTSLK 150
VPLARSLQIS EELLSRNQLS TAASLGPSGL QNHGQHLILS REASWAKPHY 200
EFNLSRMKFR GNGALSNISD LPFLAENSAF PKMALQAKQD GKKDVSHSSP 250
VDLKIPQVRG MDLSWESRTG DQYSYSSLVM GSQTESALSK KLRAILPKQS 300
RKSMLDAGPD SWGSDAEQST SGQPYPTSDQ EGDPGSKQPR KKRGRYRQYN 350
SEILEEAISV VMSGKMSVSK AQSIYGIPHS TLEYKVKERL GTLKNPPKKK 400
MKLMRSEGPD VSVKIELDPQ GEAAQSANES KNE 433
Length:433
Mass (Da):47,007
Last modified:May 30, 2006 - v2
Checksum:i5F934FE687417740
GO
Isoform 2 (identifier: Q96JN0-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     405-406: RS → SG
     407-433: Missing.

Show »
Length:406
Mass (Da):44,083
Checksum:iACE760CF3CB1F2EF
GO

Sequence cautioni

The sequence BAB47424.1 differs from that shown. Reason: Erroneous initiation.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei405 – 4062RS → SG in isoform 2.
VSP_018585
Alternative sequencei407 – 43327Missing in isoform 2.
VSP_018586Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti6 – 61Q → P in CAD91159. 1 Publication
Sequence conflicti321 – 3211S → P in CAD38921. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB058698 mRNA. Translation: BAB47424.1. Different initiation.
AL834245 mRNA. Translation: CAD38921.2.
AL832106 mRNA. Translation: CAD91159.1.
AL832044 mRNA. Translation: CAD91160.1.
AL442123 Genomic DNA. Translation: CAH70915.1.
CH471066 Genomic DNA. Translation: EAW49963.1.
CH471066 Genomic DNA. Translation: EAW49965.1.
CH471066 Genomic DNA. Translation: EAW49966.1.
BC053359 mRNA. Translation: AAH53359.1.
CCDSiCCDS53561.1. [Q96JN0-2]
CCDS7451.1. [Q96JN0-1]
RefSeqiNP_001164236.1. NM_001170765.1. [Q96JN0-1]
NP_001164237.1. NM_001170766.1. [Q96JN0-2]
NP_115816.2. NM_032440.3. [Q96JN0-1]
XP_006718097.1. XM_006718034.1. [Q96JN0-1]
UniGeneiHs.745068.

Genome annotation databases

EnsembliENST00000356016; ENSP00000348298; ENSG00000196233. [Q96JN0-1]
ENST00000371097; ENSP00000360138; ENSG00000196233. [Q96JN0-1]
ENST00000371103; ENSP00000360144; ENSG00000196233. [Q96JN0-1]
ENST00000540664; ENSP00000443431; ENSG00000196233. [Q96JN0-2]
GeneIDi84458.
KEGGihsa:84458.
UCSCiuc001kmr.3. human. [Q96JN0-2]
uc001kms.2. human. [Q96JN0-1]

Polymorphism databases

DMDMi108936028.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB058698 mRNA. Translation: BAB47424.1 . Different initiation.
AL834245 mRNA. Translation: CAD38921.2 .
AL832106 mRNA. Translation: CAD91159.1 .
AL832044 mRNA. Translation: CAD91160.1 .
AL442123 Genomic DNA. Translation: CAH70915.1 .
CH471066 Genomic DNA. Translation: EAW49963.1 .
CH471066 Genomic DNA. Translation: EAW49965.1 .
CH471066 Genomic DNA. Translation: EAW49966.1 .
BC053359 mRNA. Translation: AAH53359.1 .
CCDSi CCDS53561.1. [Q96JN0-2 ]
CCDS7451.1. [Q96JN0-1 ]
RefSeqi NP_001164236.1. NM_001170765.1. [Q96JN0-1 ]
NP_001164237.1. NM_001170766.1. [Q96JN0-2 ]
NP_115816.2. NM_032440.3. [Q96JN0-1 ]
XP_006718097.1. XM_006718034.1. [Q96JN0-1 ]
UniGenei Hs.745068.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2COB NMR - A 343-405 [» ]
ProteinModelPortali Q96JN0.
SMRi Q96JN0. Positions 346-405.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 124093. 10 interactions.
STRINGi 9606.ENSP00000348298.

PTM databases

PhosphoSitei Q96JN0.

Polymorphism databases

DMDMi 108936028.

Proteomic databases

MaxQBi Q96JN0.
PaxDbi Q96JN0.
PRIDEi Q96JN0.

Protocols and materials databases

DNASUi 84458.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000356016 ; ENSP00000348298 ; ENSG00000196233 . [Q96JN0-1 ]
ENST00000371097 ; ENSP00000360138 ; ENSG00000196233 . [Q96JN0-1 ]
ENST00000371103 ; ENSP00000360144 ; ENSG00000196233 . [Q96JN0-1 ]
ENST00000540664 ; ENSP00000443431 ; ENSG00000196233 . [Q96JN0-2 ]
GeneIDi 84458.
KEGGi hsa:84458.
UCSCi uc001kmr.3. human. [Q96JN0-2 ]
uc001kms.2. human. [Q96JN0-1 ]

Organism-specific databases

CTDi 84458.
GeneCardsi GC10P098583.
HGNCi HGNC:29503. LCOR.
HPAi HPA031428.
MIMi 607698. gene.
neXtProti NX_Q96JN0.
PharmGKBi PA145148487.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG309364.
HOVERGENi HBG079596.
InParanoidi Q96JN0.
OMAi FQDCEPE.
OrthoDBi EOG73RBBB.
PhylomeDBi Q96JN0.
TreeFami TF319589.

Miscellaneous databases

EvolutionaryTracei Q96JN0.
GeneWikii LCOR.
GenomeRNAii 84458.
NextBioi 74251.
PROi Q96JN0.
SOURCEi Search...

Gene expression databases

Bgeei Q96JN0.
CleanExi HS_LCOR.
Genevestigatori Q96JN0.

Family and domain databases

InterProi IPR009057. Homeodomain-like.
IPR007889. HTH_Psq.
[Graphical view ]
Pfami PF05225. HTH_psq. 1 hit.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 1 hit.
PROSITEi PS50960. HTH_PSQ. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Nakayama M., Nakajima D., Kikuno R., Ohara O.
    DNA Res. 8:85-95(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Bone marrow and Skeletal muscle.
  3. "The DNA sequence and comparative analysis of human chromosome 10."
    Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
    , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
    Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Lung.
  6. "Ligand-dependent nuclear receptor corepressor LCoR functions by histone deacetylase-dependent and -independent mechanisms."
    Fernandes I., Bastien Y., Wai T., Nygard K., Lin R., Cormier O., Lee H.S., Eng F., Bertos N.R., Pelletier N., Mader S., Han V.K.M., Yang X.-J., White J.H.
    Mol. Cell 11:139-150(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH CTBP1; ESR1; ESR2; HDAC3 AND HDAC6, SUBCELLULAR LOCATION, MUTAGENESIS OF 56-LEU-LEU-57, TISSUE SPECIFICITY.
  7. "Coordinated histone modifications mediated by a CtBP co-repressor complex."
    Shi Y., Sawada J., Sui G., Affar E.B., Whetstine J.R., Lan F., Ogawa H., Luke M.P.-S., Nakatani Y., Shi Y.
    Nature 422:735-738(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN A COREPRESSOR COMPLEX, IDENTIFICATION BY MASS SPECTROMETRY.
  8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  9. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  10. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-63 AND SER-249, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  11. "Solution structures of the HTH domain of human LCOR protein."
    RIKEN structural genomics initiative (RSGI)
    Submitted (NOV-2005) to the PDB data bank
    Cited for: STRUCTURE BY NMR OF 343-405.

Entry informationi

Entry nameiLCOR_HUMAN
AccessioniPrimary (citable) accession number: Q96JN0
Secondary accession number(s): D3DR47
, Q5VW16, Q7Z723, Q86T32, Q86T33, Q8N3L6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: May 30, 2006
Last modified: July 9, 2014
This is version 91 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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