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Protein

Lethal(3)malignant brain tumor-like protein 3

Gene

L3MBTL3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Putative Polycomb group (PcG) protein. PcG proteins maintain the transcriptionally repressive state of genes, probably via a modification of chromatin, rendering it heritably changed in its expressibility. Required for normal maturation of myeloid progenitor cells (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri549 – 593CCHHC-type; degeneratePROSITE-ProRule annotationAdd BLAST45

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator

Keywords - Biological processi

Transcription, Transcription regulation

Enzyme and pathway databases

BioCyciZFISH:G66-33017-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Lethal(3)malignant brain tumor-like protein 3
Short name:
H-l(3)mbt-like protein 3
Short name:
L(3)mbt-like protein 3
Alternative name(s):
MBT-1
Gene namesi
Name:L3MBTL3
Synonyms:KIAA1798, MBT1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:23035. L3MBTL3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi84456.
OpenTargetsiENSG00000198945.
PharmGKBiPA134943930.

Chemistry databases

ChEMBLiCHEMBL1287623.
GuidetoPHARMACOLOGYi2830.

Polymorphism and mutation databases

BioMutaiL3MBTL3.
DMDMi62900619.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000844501 – 780Lethal(3)malignant brain tumor-like protein 3Add BLAST780

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei608PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ96JM7.
MaxQBiQ96JM7.
PaxDbiQ96JM7.
PeptideAtlasiQ96JM7.
PRIDEiQ96JM7.

PTM databases

iPTMnetiQ96JM7.
PhosphoSitePlusiQ96JM7.
SwissPalmiQ96JM7.

Expressioni

Gene expression databases

BgeeiENSG00000198945.
CleanExiHS_L3MBTL3.
ExpressionAtlasiQ96JM7. baseline and differential.
GenevisibleiQ96JM7. HS.

Organism-specific databases

HPAiHPA053035.

Interactioni

Subunit structurei

Interacts with RNF2.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
G2XKQ03EBI-2686809,EBI-10175576
ASB6Q9NWX53EBI-2686809,EBI-6425205
BANPQ8N9N53EBI-2686809,EBI-744695
BYSLQ138955EBI-2686809,EBI-358049
LSM4Q9Y4Z03EBI-2686809,EBI-372521
MAPK9P459843EBI-2686809,EBI-713568
MORF4L1Q9UBU83EBI-2686809,EBI-399246
MORF4L2Q150143EBI-2686809,EBI-399257
NGBQ9NPG23EBI-2686809,EBI-10311409
OAZ3Q9UMX23EBI-2686809,EBI-10281601
PDE6GP185453EBI-2686809,EBI-2622029
PHC2Q8IXK06EBI-2686809,EBI-713786
PIK3R3Q8N3813EBI-2686809,EBI-749096
PLEKHF1Q96S993EBI-2686809,EBI-745767
PLEKHF2Q9H8W43EBI-2686809,EBI-742388
POLR2LP628753EBI-2686809,EBI-359527
PRKAA1Q131313EBI-2686809,EBI-1181405
PRKAA2P546463EBI-2686809,EBI-1383852
SFMBT2Q5VUG04EBI-11985629,EBI-12025260
SNRPBP14678-23EBI-2686809,EBI-372475
SP100P234973EBI-2686809,EBI-751145
THRAP108273EBI-2686809,EBI-286285
TTC19Q6DKK23EBI-2686809,EBI-948354

Protein-protein interaction databases

BioGridi124091. 37 interactors.
DIPiDIP-42798N.
IntActiQ96JM7. 61 interactors.
MINTiMINT-1623804.
STRINGi9606.ENSP00000354526.

Chemistry databases

BindingDBiQ96JM7.

Structurei

Secondary structure

1780
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi234 – 241Combined sources8
Helixi248 – 250Combined sources3
Turni253 – 255Combined sources3
Beta strandi269 – 274Combined sources6
Beta strandi277 – 290Combined sources14
Beta strandi293 – 298Combined sources6
Helixi303 – 305Combined sources3
Beta strandi307 – 310Combined sources4
Beta strandi314 – 317Combined sources4
Helixi321 – 325Combined sources5
Turni337 – 339Combined sources3
Helixi342 – 348Combined sources7
Helixi356 – 358Combined sources3
Turni360 – 363Combined sources4
Beta strandi376 – 381Combined sources6
Beta strandi384 – 397Combined sources14
Beta strandi400 – 405Combined sources6
Helixi410 – 412Combined sources3
Beta strandi414 – 416Combined sources3
Helixi428 – 431Combined sources4
Helixi445 – 447Combined sources3
Helixi450 – 456Combined sources7
Helixi464 – 466Combined sources3
Beta strandi472 – 474Combined sources3
Beta strandi480 – 484Combined sources5
Beta strandi486 – 488Combined sources3
Beta strandi492 – 500Combined sources9
Beta strandi502 – 509Combined sources8
Beta strandi510 – 512Combined sources3
Helixi514 – 516Combined sources3
Beta strandi518 – 521Combined sources4
Helixi532 – 536Combined sources5
Turni546 – 549Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WJQNMR-A469-562[»]
1WJSNMR-A258-371[»]
3UT1X-ray2.05A228-551[»]
4FL6X-ray2.55A/B229-553[»]
4L59X-ray2.29A228-544[»]
ProteinModelPortaliQ96JM7.
SMRiQ96JM7.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ96JM7.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati232 – 332MBT 1Add BLAST101
Repeati340 – 439MBT 2Add BLAST100
Repeati448 – 543MBT 3Add BLAST96
Domaini708 – 772SAMPROSITE-ProRule annotationAdd BLAST65

Sequence similaritiesi

Contains 1 CCHHC-type zinc finger.PROSITE-ProRule annotation
Contains 3 MBT repeats.PROSITE-ProRule annotation
Contains 1 SAM (sterile alpha motif) domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri549 – 593CCHHC-type; degeneratePROSITE-ProRule annotationAdd BLAST45

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG3766. Eukaryota.
ENOG410Y4AQ. LUCA.
GeneTreeiENSGT00760000119024.
HOGENOMiHOG000231019.
HOVERGENiHBG071375.
InParanoidiQ96JM7.
OMAiEYQSFPY.
OrthoDBiEOG091G01BW.
PhylomeDBiQ96JM7.
TreeFamiTF316498.

Family and domain databases

Gene3Di1.10.150.50. 1 hit.
InterProiIPR004092. Mbt.
IPR001660. SAM.
IPR013761. SAM/pointed.
[Graphical view]
PfamiPF02820. MBT. 3 hits.
PF00536. SAM_1. 1 hit.
[Graphical view]
SMARTiSM00561. MBT. 3 hits.
SM00454. SAM. 1 hit.
[Graphical view]
SUPFAMiSSF47769. SSF47769. 1 hit.
PROSITEiPS51079. MBT. 3 hits.
PS50105. SAM_DOMAIN. 1 hit.
PS51802. ZF_CCHHC. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96JM7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTESASSTSG QEFDVFSVMD WKDGVGTLPG SDLKFRVNEF GALEVITDEN
60 70 80 90 100
EMENVKKATA TTTWMVPTAQ EAPTSPPSSR PVFPPAYWTS PPGCPTVFSE
110 120 130 140 150
KTGMPFRLKD PVKVEGLQFC ENCCQYGNVD ECLSGGNYCS QNCARHIKDK
160 170 180 190 200
DQKEERDVEE DNEEEDPKCS RKKKPKLSLK ADTKEDGEER DDEMENKQDV
210 220 230 240 250
RILRGSQRAR RKRRGDSAVL KQGLPPKGKK AWCWASYLEE EKAVAVPAKL
260 270 280 290 300
FKEHQSFPYN KNGFKVGMKL EGVDPEHQSV YCVLTVAEVC GYRIKLHFDG
310 320 330 340 350
YSDCYDFWVN ADALDIHPVG WCEKTGHKLH PPKGYKEEEF NWQTYLKTCK
360 370 380 390 400
AQAAPKSLFE NQNITVIPSG FRVGMKLEAV DKKNPSFICV ATVTDMVDNR
410 420 430 440 450
FLVHFDNWDE SYDYWCEASS PHIHPVGWCK EHRRTLITPP GYPNVKHFSW
460 470 480 490 500
DKYLEETNSL PAPARAFKVK PPHGFQKKMK LEVVDKRNPM FIRVATVADT
510 520 530 540 550
DDHRVKVHFD GWNNCYDYWI DADSPDIHPV GWCSKTGHPL QPPLSPLELM
560 570 580 590 600
EASEHGGCST PGCKGIGHFK RARHLGPHSA ANCPYSEINL NKDRIFPDRL
610 620 630 640 650
SGEMPPASPS FPRNKRTDAN ESSSSPEIRD QHADDVKEDF EERTESEMRT
660 670 680 690 700
SHEARGAREE PTVQQAQRRS AVFLSFKSPI PCLPLRWEQQ SKLLPTVAGI
710 720 730 740 750
PASKVSKWST DEVSEFIQSL PGCEEHGKVF KDEQIDGEAF LLMTQTDIVK
760 770 780
IMSIKLGPAL KIFNSILMFK AAEKNSHNEL
Length:780
Mass (Da):88,337
Last modified:April 26, 2005 - v2
Checksum:i81F92D4423E25C84
GO
Isoform 2 (identifier: Q96JM7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     72-96: Missing.

Show »
Length:755
Mass (Da):85,757
Checksum:iCC4B216CF46941EC
GO

Sequence cautioni

The sequence BAB47427 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_022368183T → N.2 PublicationsCorresponds to variant rs9388768dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_01350872 – 96Missing in isoform 2. 1 PublicationAdd BLAST25

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB058701 mRNA. Translation: BAB47427.1. Different initiation.
AL583846, AL355581 Genomic DNA. Translation: CAH73677.1.
AL355581, AL583846 Genomic DNA. Translation: CAI95325.1.
CH471051 Genomic DNA. Translation: EAW48073.1.
BC060845 mRNA. Translation: AAH60845.1.
CCDSiCCDS34537.1. [Q96JM7-1]
CCDS34538.1. [Q96JM7-2]
RefSeqiNP_001007103.1. NM_001007102.2. [Q96JM7-2]
NP_115814.1. NM_032438.2. [Q96JM7-1]
XP_005267218.1. XM_005267161.4. [Q96JM7-1]
XP_006715641.1. XM_006715578.3. [Q96JM7-1]
XP_011534481.1. XM_011536179.2. [Q96JM7-1]
XP_011534482.1. XM_011536180.2. [Q96JM7-1]
XP_011534483.1. XM_011536181.2. [Q96JM7-1]
XP_011534485.1. XM_011536183.2. [Q96JM7-1]
XP_011534486.1. XM_011536184.2. [Q96JM7-1]
XP_016866844.1. XM_017011355.1. [Q96JM7-2]
XP_016866845.1. XM_017011356.1. [Q96JM7-2]
UniGeneiHs.658051.

Genome annotation databases

EnsembliENST00000361794; ENSP00000354526; ENSG00000198945. [Q96JM7-1]
ENST00000368136; ENSP00000357118; ENSG00000198945. [Q96JM7-1]
ENST00000368139; ENSP00000357121; ENSG00000198945. [Q96JM7-2]
ENST00000526019; ENSP00000436706; ENSG00000198945. [Q96JM7-2]
ENST00000529410; ENSP00000431962; ENSG00000198945. [Q96JM7-1]
ENST00000533560; ENSP00000437185; ENSG00000198945. [Q96JM7-2]
GeneIDi84456.
KEGGihsa:84456.
UCSCiuc003qbt.4. human. [Q96JM7-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB058701 mRNA. Translation: BAB47427.1. Different initiation.
AL583846, AL355581 Genomic DNA. Translation: CAH73677.1.
AL355581, AL583846 Genomic DNA. Translation: CAI95325.1.
CH471051 Genomic DNA. Translation: EAW48073.1.
BC060845 mRNA. Translation: AAH60845.1.
CCDSiCCDS34537.1. [Q96JM7-1]
CCDS34538.1. [Q96JM7-2]
RefSeqiNP_001007103.1. NM_001007102.2. [Q96JM7-2]
NP_115814.1. NM_032438.2. [Q96JM7-1]
XP_005267218.1. XM_005267161.4. [Q96JM7-1]
XP_006715641.1. XM_006715578.3. [Q96JM7-1]
XP_011534481.1. XM_011536179.2. [Q96JM7-1]
XP_011534482.1. XM_011536180.2. [Q96JM7-1]
XP_011534483.1. XM_011536181.2. [Q96JM7-1]
XP_011534485.1. XM_011536183.2. [Q96JM7-1]
XP_011534486.1. XM_011536184.2. [Q96JM7-1]
XP_016866844.1. XM_017011355.1. [Q96JM7-2]
XP_016866845.1. XM_017011356.1. [Q96JM7-2]
UniGeneiHs.658051.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WJQNMR-A469-562[»]
1WJSNMR-A258-371[»]
3UT1X-ray2.05A228-551[»]
4FL6X-ray2.55A/B229-553[»]
4L59X-ray2.29A228-544[»]
ProteinModelPortaliQ96JM7.
SMRiQ96JM7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124091. 37 interactors.
DIPiDIP-42798N.
IntActiQ96JM7. 61 interactors.
MINTiMINT-1623804.
STRINGi9606.ENSP00000354526.

Chemistry databases

BindingDBiQ96JM7.
ChEMBLiCHEMBL1287623.
GuidetoPHARMACOLOGYi2830.

PTM databases

iPTMnetiQ96JM7.
PhosphoSitePlusiQ96JM7.
SwissPalmiQ96JM7.

Polymorphism and mutation databases

BioMutaiL3MBTL3.
DMDMi62900619.

Proteomic databases

EPDiQ96JM7.
MaxQBiQ96JM7.
PaxDbiQ96JM7.
PeptideAtlasiQ96JM7.
PRIDEiQ96JM7.

Protocols and materials databases

DNASUi84456.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000361794; ENSP00000354526; ENSG00000198945. [Q96JM7-1]
ENST00000368136; ENSP00000357118; ENSG00000198945. [Q96JM7-1]
ENST00000368139; ENSP00000357121; ENSG00000198945. [Q96JM7-2]
ENST00000526019; ENSP00000436706; ENSG00000198945. [Q96JM7-2]
ENST00000529410; ENSP00000431962; ENSG00000198945. [Q96JM7-1]
ENST00000533560; ENSP00000437185; ENSG00000198945. [Q96JM7-2]
GeneIDi84456.
KEGGihsa:84456.
UCSCiuc003qbt.4. human. [Q96JM7-1]

Organism-specific databases

CTDi84456.
DisGeNETi84456.
GeneCardsiL3MBTL3.
HGNCiHGNC:23035. L3MBTL3.
HPAiHPA053035.
neXtProtiNX_Q96JM7.
OpenTargetsiENSG00000198945.
PharmGKBiPA134943930.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3766. Eukaryota.
ENOG410Y4AQ. LUCA.
GeneTreeiENSGT00760000119024.
HOGENOMiHOG000231019.
HOVERGENiHBG071375.
InParanoidiQ96JM7.
OMAiEYQSFPY.
OrthoDBiEOG091G01BW.
PhylomeDBiQ96JM7.
TreeFamiTF316498.

Enzyme and pathway databases

BioCyciZFISH:G66-33017-MONOMER.

Miscellaneous databases

ChiTaRSiL3MBTL3. human.
EvolutionaryTraceiQ96JM7.
GenomeRNAii84456.
PROiQ96JM7.

Gene expression databases

BgeeiENSG00000198945.
CleanExiHS_L3MBTL3.
ExpressionAtlasiQ96JM7. baseline and differential.
GenevisibleiQ96JM7. HS.

Family and domain databases

Gene3Di1.10.150.50. 1 hit.
InterProiIPR004092. Mbt.
IPR001660. SAM.
IPR013761. SAM/pointed.
[Graphical view]
PfamiPF02820. MBT. 3 hits.
PF00536. SAM_1. 1 hit.
[Graphical view]
SMARTiSM00561. MBT. 3 hits.
SM00454. SAM. 1 hit.
[Graphical view]
SUPFAMiSSF47769. SSF47769. 1 hit.
PROSITEiPS51079. MBT. 3 hits.
PS50105. SAM_DOMAIN. 1 hit.
PS51802. ZF_CCHHC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLMBL3_HUMAN
AccessioniPrimary (citable) accession number: Q96JM7
Secondary accession number(s): Q4VXE1, Q5VUM9, Q6P9B5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: April 26, 2005
Last modified: November 30, 2016
This is version 138 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.