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Q96JM2

- ZN462_HUMAN

UniProt

Q96JM2 - ZN462_HUMAN

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Protein

Zinc finger protein 462

Gene
ZNF462, KIAA1803
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri4 – 2724C2H2-type 1Add
BLAST
Zinc fingeri108 – 13124C2H2-type 2Add
BLAST
Zinc fingeri162 – 18524C2H2-type 3Add
BLAST
Zinc fingeri439 – 46224C2H2-type 4Add
BLAST
Zinc fingeri470 – 49223C2H2-type 5Add
BLAST
Zinc fingeri600 – 62324C2H2-type 6Add
BLAST
Zinc fingeri843 – 86624C2H2-type 7Add
BLAST
Zinc fingeri886 – 90823C2H2-type 8Add
BLAST
Zinc fingeri925 – 94824C2H2-type 9Add
BLAST
Zinc fingeri1030 – 105324C2H2-type 10Add
BLAST
Zinc fingeri1265 – 128824C2H2-type 11Add
BLAST
Zinc fingeri1470 – 149324C2H2-type 12Add
BLAST
Zinc fingeri1515 – 153824C2H2-type 13Add
BLAST
Zinc fingeri1577 – 160024C2H2-type 14Add
BLAST
Zinc fingeri1660 – 168324C2H2-type 15Add
BLAST
Zinc fingeri1697 – 172024C2H2-type 16Add
BLAST
Zinc fingeri1892 – 191423C2H2-type 17Add
BLAST
Zinc fingeri1968 – 199225C2H2-type 18; degenerateAdd
BLAST
Zinc fingeri2025 – 204824C2H2-type 19Add
BLAST
Zinc fingeri2054 – 207724C2H2-type 20Add
BLAST
Zinc fingeri2083 – 210624C2H2-type 21Add
BLAST
Zinc fingeri2191 – 221424C2H2-type 22Add
BLAST
Zinc fingeri2220 – 224324C2H2-type 23Add
BLAST
Zinc fingeri2254 – 227623C2H2-type 24Add
BLAST
Zinc fingeri2300 – 232223C2H2-type 25Add
BLAST
Zinc fingeri2328 – 235124C2H2-type 26Add
BLAST
Zinc fingeri2414 – 243623C2H2-type 27Add
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. chromatin organization Source: Ensembl
  2. negative regulation of DNA binding Source: Ensembl
  3. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  4. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 462
Gene namesi
Name:ZNF462
Synonyms:KIAA1803
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 9

Organism-specific databases

HGNCiHGNC:21684. ZNF462.

Subcellular locationi

Nucleus Reviewed prediction

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134949139.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 25062506Zinc finger protein 462PRO_0000047601Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi292 – 2921O-linked (GlcNAc6P)1 Publication
Glycosylationi309 – 3091O-linked (GlcNAc6P)1 Publication
Modified residuei350 – 3501Phosphoserine1 Publication
Modified residuei354 – 3541Phosphoserine1 Publication
Modified residuei688 – 6881Phosphoserine2 Publications
Modified residuei1090 – 10901Phosphoserine1 Publication
Modified residuei1166 – 11661Phosphoserine1 Publication
Modified residuei2172 – 21721Phosphoserine1 Publication
Modified residuei2177 – 21771Phosphoserine1 Publication

Post-translational modificationi

O-GlcNAcylated with O-GlcNAc-6-phosphate.

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ96JM2.
PaxDbiQ96JM2.
PRIDEiQ96JM2.

PTM databases

PhosphoSiteiQ96JM2.

Expressioni

Gene expression databases

ArrayExpressiQ96JM2.
BgeeiQ96JM2.
CleanExiHS_ZNF462.
GenevestigatoriQ96JM2.

Organism-specific databases

HPAiHPA022283.

Interactioni

Protein-protein interaction databases

BioGridi121829. 4 interactions.
DIPiDIP-39340N.
IntActiQ96JM2. 4 interactions.
STRINGi9606.ENSP00000277225.

Structurei

Secondary structure

1
2506
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi1895 – 18973
Beta strandi1900 – 19034
Helixi1904 – 192118
Beta strandi1941 – 19433

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1X6FNMR-A1874-1948[»]
ProteinModelPortaliQ96JM2.
SMRiQ96JM2. Positions 83-184, 216-262, 566-618, 1871-1948, 1968-2101, 2189-2357, 2403-2436.

Miscellaneous databases

EvolutionaryTraceiQ96JM2.

Family & Domainsi

Sequence similaritiesi

Contains 27 C2H2-type zinc fingers.

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri4 – 2724C2H2-type 1Add
BLAST
Zinc fingeri108 – 13124C2H2-type 2Add
BLAST
Zinc fingeri162 – 18524C2H2-type 3Add
BLAST
Zinc fingeri439 – 46224C2H2-type 4Add
BLAST
Zinc fingeri470 – 49223C2H2-type 5Add
BLAST
Zinc fingeri600 – 62324C2H2-type 6Add
BLAST
Zinc fingeri843 – 86624C2H2-type 7Add
BLAST
Zinc fingeri886 – 90823C2H2-type 8Add
BLAST
Zinc fingeri925 – 94824C2H2-type 9Add
BLAST
Zinc fingeri1030 – 105324C2H2-type 10Add
BLAST
Zinc fingeri1265 – 128824C2H2-type 11Add
BLAST
Zinc fingeri1470 – 149324C2H2-type 12Add
BLAST
Zinc fingeri1515 – 153824C2H2-type 13Add
BLAST
Zinc fingeri1577 – 160024C2H2-type 14Add
BLAST
Zinc fingeri1660 – 168324C2H2-type 15Add
BLAST
Zinc fingeri1697 – 172024C2H2-type 16Add
BLAST
Zinc fingeri1892 – 191423C2H2-type 17Add
BLAST
Zinc fingeri1968 – 199225C2H2-type 18; degenerateAdd
BLAST
Zinc fingeri2025 – 204824C2H2-type 19Add
BLAST
Zinc fingeri2054 – 207724C2H2-type 20Add
BLAST
Zinc fingeri2083 – 210624C2H2-type 21Add
BLAST
Zinc fingeri2191 – 221424C2H2-type 22Add
BLAST
Zinc fingeri2220 – 224324C2H2-type 23Add
BLAST
Zinc fingeri2254 – 227623C2H2-type 24Add
BLAST
Zinc fingeri2300 – 232223C2H2-type 25Add
BLAST
Zinc fingeri2328 – 235124C2H2-type 26Add
BLAST
Zinc fingeri2414 – 243623C2H2-type 27Add
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiNOG325150.
HOGENOMiHOG000049226.
HOVERGENiHBG058189.
OMAiMMRGAEG.
OrthoDBiEOG779NWW.
PhylomeDBiQ96JM2.
TreeFamiTF325534.

Family and domain databases

InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 34 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 8 hits.
PS50157. ZINC_FINGER_C2H2_2. 9 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q96JM2-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MEVLQCDGCD FRAPSYEDLK AHIQDVHTAF LQPTDVAEDN VNELRCGSVN     50
ASNQTEVEFS SIKDEFAIAE DLSGQNATSL GTGGYYGHSP GYYGQHIAAN 100
PKPTNKFFQC KFCVRYFRSK NLLIEHTRKV HGAQAEGSSS GPPVPGSLNY 150
NIMMHEGFGK VFSCQFCTYK SPRRARIIKH QKMYHKNNLK ETTAPPPAPA 200
PMPDPVVPPV SLQDPCKELP AEVVERSILE SMVKPLTKSR GNFCCEWCSY 250
QTPRRERWCD HMMKKHRSMV KILSSLRQQQ EGTNLPDVPN KSAPSPTSNS 300
TYLTMNAASR EIPNTTVSNF RGSMGNSIMR PNSSASKFSP MSYPQMKPKS 350
PHNSGLVNLT ERSRYGMTDM TNSSADLETN SMLNDSSSDE ELNEIDSENG 400
LSAMDHQTSG LSAEQLMGSD GNKLLETKGI PFRRFMNRFQ CPFCPFLTMH 450
RRSISRHIEN IHLSGKTAVY KCDECPFTCK SSLKLGAHKQ CHTGTTSDWD 500
AVNSQSESIS SSLNEGVVSY ESSSINGRKS GVMLDPLQQQ QPPQPPPPPP 550
PPPPSQPQPL QQPQPPQLQP PHQVPPQPQT QPPPTQQPQP PTQAAPLHPY 600
KCTMCNYSTT TLKGLRVHQQ HKHSFCDNLP KFEGQPSSLP LENETDSHPS 650
SSNTVKKSQT SILGLSSKNN FVAKASRKLA NDFPLDLSPV KKRTRIDEIA 700
SNLQSKINQT KQQEDAVINV EDDEEEEEDN EVEIEVELDR EEEPTEPIIE 750
VPTSFSAQQI WVRDTSEPQK EPNFRNITHD YNATNGAEIE LTLSEDEEDY 800
YGSSTNLKDH QVSNTALLNT QTPIYGTEHN SENTDFGDSG RLYYCKHCDF 850
NNKSARSVST HYQRMHPYIK FSFRYILDPN DHSAVYRCLE CYIDYTNFED 900
LQQHYGEHHP EAMNVLNFDH SDLIYRCRFC SYTSPNVRSL MPHYQRMHPT 950
VKINNAMIFS SYVVEQQEGL NTESQTLREI LNSAPKNMAT STPVARGGGL 1000
PATFNKNTPK TFTPECENQK DPLVNTVVVY DCDVCSFASP NMHSVLVHYQ 1050
KKHPEEKASY FRIQKTMRMV SVDRGSALSQ LSFEVGAPMS PKMSNMGSPP 1100
PPQPPPPDLS TELYYCKHCS YSNRSVVGVL VHYQKRHPEI KVTAKYIRQA 1150
PPTAAMMRGV EGPQGSPRPP APIQQLNRSS SERDGPPVEN EMFFCQHCDY 1200
GNRTVKGVLI HYQKKHRDFK ANADVIRQHT ATIRSLCDRN QKKPASCVLV 1250
SPSNLERDKT KLRALKCRQC SYTSPYFYAL RKHIKKDHPA LKATVTSIMR 1300
WAFLDGLIEA GYHCEWCIYS HTEPNGLLLH YQRRHPEHYV DYTYMATKLW 1350
AGPDPSPPSL TMPAEAKTYR CRDCVFEAVS IWDITNHYQA FHPWAMNGDE 1400
SVLLDIIKEK DAVEKPILSS EELAGPVNCE NSIPTPFPEQ EAECPEDARL 1450
SPEKSLQLAS ANPAISSTPY QCTVCQSEYN NLHGLLTHYG KKHPGMKVKA 1500
ADFAQDIDIN PGAVYKCRHC PYINTRIHGV LTHYQKRHPS IKVTAEDFVH 1550
DVEQSADISQ NDVEETSRIF KQGYGAYRCK LCPYTHGTLE KLKIHYEKYH 1600
NQPEFDVFSQ SPPKLPVPLE PEMTTEVSPS QVSITEEEVG EEPVSTSHFS 1650
TSHLVSHTVF RCQLCKYFCS TRKGIARHYR IKHNNVRAQP EGKNNLFKCA 1700
LCAYTNPIRK GLAAHYQKRH DIDAYYTHCL AASRTISDKP NKVIIPSPPK 1750
DDSPQLSEEL RRAVEKKKCS LCSFQSFSKK GIVSHYMKRH PGVFPKKQHA 1800
SKLGGYFTAV YADEHEKPTL MEEEERGNFE KAEVEGEAQE IEWLPFRCIK 1850
CFKLSFSTAE LLCMHYTDHH SRDLKRDFII LGNGPRLQNS TYQCKHCDSK 1900
LQSTAELTSH LNIHNEEFQK RAKRQERRKQ LLSKQKYADG AFADFKQERP 1950
FGHLEEVPKI KERKVVGYKC KFCVEVHPTL RAICNHLRKH VQYGNVPAVS 2000
AAVKGLRSHE RSHLALAMFT REDKYSCQYC SFVSAFRHNL DRHMQTHHGH 2050
HKPFRCKLCS FKSSYNSRLK THILKAHAGE HAYKCSWCSF STMTISQLKE 2100
HSLKVHGKAL TLPRPRIVSL LSSHSHHSSQ KATPAEEVED SNDSSYSEPP 2150
DVQQQLNHYQ SAALARNNSR VSPVPLSGAA AGTEQKTEAV LHCEFCEFSS 2200
GYIQSIRRHY RDKHGGKKLF KCKDCSFYTG FKSAFTMHVE AGHSAVPEEG 2250
PKDLRCPLCL YHTKYKRNMI DHIVLHREER VVPIEVCRSK LSKYLQGVVF 2300
RCDKCTFTCS SDESLQQHIE KHNELKPYKC QLCYYETKHT EELDSHLRDE 2350
HKVSRNFELV GRVNLDQLEQ MKEKMESSSS DDEDKEEEMN SKAEDRELMR 2400
FSDHGAALNT EKRFPCEFCG RAFSQGSEWE RHVLRHGMAL NDTKQVSREE 2450
IHPKEIMENS VKMPSIEEKE DDEAIGIDFS LKNETVAICV VTADKSLLEN 2500
AEAKKE 2506
Length:2,506
Mass (Da):284,688
Last modified:May 26, 2009 - v3
Checksum:iBE921753A66384DB
GO
Isoform 2 (identifier: Q96JM2-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1155: Missing.
     2004-2004: K → KQEADDPAHLFLDGLEAAKDASGALVGRVDGEHCLLDGMLEDETRPGGYHCSQCDRVLMSMQ

Note: No experimental confirmation available.

Show »
Length:1,412
Mass (Da):161,530
Checksum:i6C979F201AABC035
GO
Isoform 3 (identifier: Q96JM2-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     2004-2004: K → KEADDPAHLFLDGLEAAKDASGALVGRVDGEHCLLDGMLEDETRPGGYHCSQCDRVLMSMQ

Show »
Length:2,566
Mass (Da):291,117
Checksum:i7073E699016C8FCD
GO

Sequence cautioni

The sequence AAH36884.1 differs from that shown. Reason: Erroneous initiation.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti404 – 4041M → V.
Corresponds to variant rs17723637 [ dbSNP | Ensembl ].
VAR_058301
Natural varianti1187 – 11871P → S.
Corresponds to variant rs3814541 [ dbSNP | Ensembl ].
VAR_058302
Natural varianti1828 – 18281N → S.
Corresponds to variant rs3814538 [ dbSNP | Ensembl ].
VAR_058303
Natural varianti2052 – 20521K → R.
Corresponds to variant rs7020769 [ dbSNP | Ensembl ].
VAR_058304
Natural varianti2452 – 24521H → L.
Corresponds to variant rs10217192 [ dbSNP | Ensembl ].
VAR_058305

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 11551155Missing in isoform 2. VSP_037407Add
BLAST
Alternative sequencei2004 – 20041K → KQEADDPAHLFLDGLEAAKD ASGALVGRVDGEHCLLDGML EDETRPGGYHCSQCDRVLMS MQ in isoform 2. VSP_037408
Alternative sequencei2004 – 20041K → KEADDPAHLFLDGLEAAKDA SGALVGRVDGEHCLLDGMLE DETRPGGYHCSQCDRVLMSM Q in isoform 3. VSP_037409

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti1241 – 12411Q → R in AK027866. 1 Publication
Sequence conflicti1250 – 12501V → I in AK027866. 1 Publication
Sequence conflicti1332 – 13321Q → R in AK027866. 1 Publication
Sequence conflicti1424 – 14241A → T in AK027866. 1 Publication
Sequence conflicti1430 – 14301E → A in AK027866. 1 Publication
Sequence conflicti1936 – 19361K → E in AK027866. 1 Publication
Sequence conflicti2030 – 20301C → S in AK027866. 1 Publication
Sequence conflicti2277 – 22771Missing in AK027866. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB058706 mRNA. Translation: BAB47432.2.
AL512593 Genomic DNA. Translation: CAI14941.1.
AK027866 mRNA. No translation available.
BC036884 mRNA. Translation: AAH36884.1. Different initiation.
CCDSiCCDS35096.1. [Q96JM2-1]
RefSeqiNP_067047.4. NM_021224.4. [Q96JM2-1]
XP_006717278.1. XM_006717215.1. [Q96JM2-3]
XP_006717279.1. XM_006717216.1. [Q96JM2-1]
UniGeneiHs.370379.

Genome annotation databases

EnsembliENST00000277225; ENSP00000277225; ENSG00000148143. [Q96JM2-1]
ENST00000441147; ENSP00000397306; ENSG00000148143. [Q96JM2-2]
ENST00000457913; ENSP00000414570; ENSG00000148143. [Q96JM2-3]
GeneIDi58499.
KEGGihsa:58499.
UCSCiuc004bcz.3. human. [Q96JM2-1]
uc004bda.3. human. [Q96JM2-3]

Polymorphism databases

DMDMi238054352.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB058706 mRNA. Translation: BAB47432.2 .
AL512593 Genomic DNA. Translation: CAI14941.1 .
AK027866 mRNA. No translation available.
BC036884 mRNA. Translation: AAH36884.1 . Different initiation.
CCDSi CCDS35096.1. [Q96JM2-1 ]
RefSeqi NP_067047.4. NM_021224.4. [Q96JM2-1 ]
XP_006717278.1. XM_006717215.1. [Q96JM2-3 ]
XP_006717279.1. XM_006717216.1. [Q96JM2-1 ]
UniGenei Hs.370379.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1X6F NMR - A 1874-1948 [» ]
ProteinModelPortali Q96JM2.
SMRi Q96JM2. Positions 83-184, 216-262, 566-618, 1871-1948, 1968-2101, 2189-2357, 2403-2436.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 121829. 4 interactions.
DIPi DIP-39340N.
IntActi Q96JM2. 4 interactions.
STRINGi 9606.ENSP00000277225.

PTM databases

PhosphoSitei Q96JM2.

Polymorphism databases

DMDMi 238054352.

Proteomic databases

MaxQBi Q96JM2.
PaxDbi Q96JM2.
PRIDEi Q96JM2.

Protocols and materials databases

DNASUi 58499.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000277225 ; ENSP00000277225 ; ENSG00000148143 . [Q96JM2-1 ]
ENST00000441147 ; ENSP00000397306 ; ENSG00000148143 . [Q96JM2-2 ]
ENST00000457913 ; ENSP00000414570 ; ENSG00000148143 . [Q96JM2-3 ]
GeneIDi 58499.
KEGGi hsa:58499.
UCSCi uc004bcz.3. human. [Q96JM2-1 ]
uc004bda.3. human. [Q96JM2-3 ]

Organism-specific databases

CTDi 58499.
GeneCardsi GC09P109626.
HGNCi HGNC:21684. ZNF462.
HPAi HPA022283.
neXtProti NX_Q96JM2.
PharmGKBi PA134949139.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG325150.
HOGENOMi HOG000049226.
HOVERGENi HBG058189.
OMAi MMRGAEG.
OrthoDBi EOG779NWW.
PhylomeDBi Q96JM2.
TreeFami TF325534.

Miscellaneous databases

ChiTaRSi ZNF462. human.
EvolutionaryTracei Q96JM2.
GenomeRNAii 58499.
NextBioi 65000.
PROi Q96JM2.

Gene expression databases

ArrayExpressi Q96JM2.
Bgeei Q96JM2.
CleanExi HS_ZNF462.
Genevestigatori Q96JM2.

Family and domain databases

InterProi IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
[Graphical view ]
SMARTi SM00355. ZnF_C2H2. 34 hits.
[Graphical view ]
PROSITEi PS00028. ZINC_FINGER_C2H2_1. 8 hits.
PS50157. ZINC_FINGER_C2H2_2. 9 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Nakayama M., Nakajima D., Kikuno R., Ohara O.
    DNA Res. 8:85-95(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Brain.
  2. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
    Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.
    DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: SEQUENCE REVISION.
  3. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1118-2506 (ISOFORM 3).
    Tissue: Placenta.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1576-2506 (ISOFORM 1).
    Tissue: Liver.
  6. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-688, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  7. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-350; SER-354; SER-688; SER-1090; SER-1166; SER-2172 AND SER-2177, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. "Discovery of O-GlcNAc-6-phosphate modified proteins in large-scale phosphoproteomics data."
    Hahne H., Kuster B.
    Mol. Cell. Proteomics 11:1063-1069(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION AT SER-292 AND SER-309.
    Tissue: Embryonic stem cell.
  9. "Solution structures of the C2H2 type zinc finger domain of human zinc finger protein 462."
    RIKEN structural genomics initiative (RSGI)
    Submitted (NOV-2005) to the PDB data bank
    Cited for: STRUCTURE BY NMR OF 1874-1948.

Entry informationi

Entry nameiZN462_HUMAN
AccessioniPrimary (citable) accession number: Q96JM2
Secondary accession number(s): Q5T0T4, Q8N408
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 2, 2004
Last sequence update: May 26, 2009
Last modified: July 9, 2014
This is version 109 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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