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Q96JL9

- ZN333_HUMAN

UniProt

Q96JL9 - ZN333_HUMAN

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Protein

Zinc finger protein 333

Gene

ZNF333

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri366 – 38823C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri394 – 41623C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri422 – 44423C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri450 – 47223C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri478 – 50023C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri506 – 52823C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri534 – 55623C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri562 – 58423C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri590 – 61223C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri618 – 64023C2H2-type 10PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_12627. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 333
Gene namesi
Name:ZNF333
Synonyms:KIAA1806
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:15624. ZNF333.

Subcellular locationi

Nucleus Curated

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134929553.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 665665Zinc finger protein 333PRO_0000047536Add
BLAST

Proteomic databases

PaxDbiQ96JL9.
PRIDEiQ96JL9.

PTM databases

PhosphoSiteiQ96JL9.

Expressioni

Tissue specificityi

Highly expressed in heart.

Gene expression databases

BgeeiQ96JL9.
CleanExiHS_ZNF333.
ExpressionAtlasiQ96JL9. baseline and differential.
GenevestigatoriQ96JL9.

Organism-specific databases

HPAiHPA043973.

Interactioni

Protein-protein interaction databases

BioGridi124087. 3 interactions.
IntActiQ96JL9. 1 interaction.
MINTiMINT-8417739.

Structurei

3D structure databases

ProteinModelPortaliQ96JL9.
SMRiQ96JL9. Positions 203-243, 304-646.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini4 – 7471KRAB 1PROSITE-ProRule annotationAdd
BLAST
Domaini203 – 27472KRAB 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 10 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 2 KRAB domains.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri366 – 38823C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri394 – 41623C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri422 – 44423C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri450 – 47223C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri478 – 50023C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri506 – 52823C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri534 – 55623C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri562 – 58423C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri590 – 61223C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri618 – 64023C2H2-type 10PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00730000110754.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ96JL9.
KOiK09228.
OMAiYACNKCE.
PhylomeDBiQ96JL9.
TreeFamiTF350814.

Family and domain databases

Gene3Di3.30.160.60. 10 hits.
InterProiIPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 2 hits.
PF00096. zf-C2H2. 2 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 10 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 2 hits.
PS00028. ZINC_FINGER_C2H2_1. 10 hits.
PS50157. ZINC_FINGER_C2H2_2. 10 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q96JL9-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MESVTFEDVA VEFIQEWALL DSARRSLCKY RMLDQCRTLA SRGTPPCKPS
60 70 80 90 100
CVSQLGQRAE PKATERGILR ATGVAWESQL KPEELPSMQD LLEEASSRDM
110 120 130 140 150
QMGPGLFLRM QLVPSIEERE TPLTREDRPA LQEPPWSLGC TGLKAAMQIQ
160 170 180 190 200
RVVIPVPTLG HRNPWVARDS AVPARDPAWL QEDKVEEEAM APGLPTACSQ
210 220 230 240 250
EPVTFADVAV VFTPEEWVFL DSTQRSLYRD VMLENYRNLA SVADQLCKPN
260 270 280 290 300
ALSYLEERGE QWTTDRGVLS DTCAEPQCQP QEAIPSQDTF TEILSIDVKG
310 320 330 340 350
EQPQPGEKLY KYNELEKPFN SIEPLFQYQR IHAGEASCEC QEIRNSFFQS
360 370 380 390 400
AHLIVPEKIR SGDKSYACNK CEKSFRYSSD LIRHEKTHTA EKCFDCQECG
410 420 430 440 450
QAFKYSSNLR RHMRTHTGEK PFECSQCGKT FTRNFNLILH QRNHTGEKPY
460 470 480 490 500
ECKDCGKAFN QPSSLRSHVR THTGEKPFEC SQCGKAFREH SSLKTHLRTH
510 520 530 540 550
TREKPYECNQ CGKPFRTSTH LNVHKRIHTG EKLYECATCG QVLSRLSTLK
560 570 580 590 600
SHMRTHTGEK PYVCQECGRA FSEPSSLRKH ARTHSGKKPY ACQECGRAFG
610 620 630 640 650
QSSHLIVHVR THSAGRPYQC NQCEKAFRHS SSLTVHKRTH VGRETIRNGS
660
LPLSMSHPYC GPLAN
Length:665
Mass (Da):75,544
Last modified:February 28, 2003 - v3
Checksum:iEE5ABF8468D8DD24
GO
Isoform 2 (identifier: Q96JL9-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     142-182: GLKAAMQIQR...PARDPAWLQE → LPLLSLLLPS...TLDTEARGIP
     183-665: Missing.

Show »
Length:182
Mass (Da):20,198
Checksum:i59AB52A753D4954E
GO
Isoform 3 (identifier: Q96JL9-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     301-302: EQ → PPN
     303-665: Missing.

Note: No experimental confirmation available.

Show »
Length:303
Mass (Da):33,917
Checksum:i0948D4793CC59D4C
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti115 – 1151S → P in AAH48107. (PubMed:15489334)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti251 – 2511A → E.
Corresponds to variant rs3885179 [ dbSNP | Ensembl ].
VAR_024210
Natural varianti537 – 5371A → V.
Corresponds to variant rs3764626 [ dbSNP | Ensembl ].
VAR_052812

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei142 – 18241GLKAA…AWLQE → LPLLSLLLPSCPEPPLVLLD SSSAPDRHLGSTLDTEARGI P in isoform 2. 2 PublicationsVSP_055945Add
BLAST
Alternative sequencei183 – 665483Missing in isoform 2. 2 PublicationsVSP_055946Add
BLAST
Alternative sequencei301 – 3022EQ → PPN in isoform 3. 1 PublicationVSP_055947
Alternative sequencei303 – 665363Missing in isoform 3. 1 PublicationVSP_055948Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF372702 mRNA. Translation: AAM15528.1.
AK291471 mRNA. Translation: BAF84160.1.
BC048107 mRNA. Translation: AAH48107.1.
BC064571 mRNA. Translation: AAH64571.1.
AB058709 mRNA. Translation: BAB47435.1.
CCDSiCCDS12316.1. [Q96JL9-1]
RefSeqiNP_115809.1. NM_032433.2.
UniGeneiHs.515215.

Genome annotation databases

EnsembliENST00000292530; ENSP00000292530; ENSG00000160961. [Q96JL9-1]
ENST00000540689; ENSP00000438130; ENSG00000160961. [Q96JL9-3]
GeneIDi84449.
KEGGihsa:84449.
UCSCiuc002mzk.4. human. [Q96JL9-1]

Polymorphism databases

DMDMi29840870.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF372702 mRNA. Translation: AAM15528.1 .
AK291471 mRNA. Translation: BAF84160.1 .
BC048107 mRNA. Translation: AAH48107.1 .
BC064571 mRNA. Translation: AAH64571.1 .
AB058709 mRNA. Translation: BAB47435.1 .
CCDSi CCDS12316.1. [Q96JL9-1 ]
RefSeqi NP_115809.1. NM_032433.2.
UniGenei Hs.515215.

3D structure databases

ProteinModelPortali Q96JL9.
SMRi Q96JL9. Positions 203-243, 304-646.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 124087. 3 interactions.
IntActi Q96JL9. 1 interaction.
MINTi MINT-8417739.

PTM databases

PhosphoSitei Q96JL9.

Polymorphism databases

DMDMi 29840870.

Proteomic databases

PaxDbi Q96JL9.
PRIDEi Q96JL9.

Protocols and materials databases

DNASUi 84449.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000292530 ; ENSP00000292530 ; ENSG00000160961 . [Q96JL9-1 ]
ENST00000540689 ; ENSP00000438130 ; ENSG00000160961 . [Q96JL9-3 ]
GeneIDi 84449.
KEGGi hsa:84449.
UCSCi uc002mzk.4. human. [Q96JL9-1 ]

Organism-specific databases

CTDi 84449.
GeneCardsi GC19P014800.
HGNCi HGNC:15624. ZNF333.
HPAi HPA043973.
MIMi 611811. gene.
neXtProti NX_Q96JL9.
PharmGKBi PA134929553.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5048.
GeneTreei ENSGT00730000110754.
HOGENOMi HOG000234617.
HOVERGENi HBG018163.
InParanoidi Q96JL9.
KOi K09228.
OMAi YACNKCE.
PhylomeDBi Q96JL9.
TreeFami TF350814.

Enzyme and pathway databases

Reactomei REACT_12627. Generic Transcription Pathway.

Miscellaneous databases

ChiTaRSi ZNF333. human.
GenomeRNAii 84449.
NextBioi 74227.
PROi Q96JL9.
SOURCEi Search...

Gene expression databases

Bgeei Q96JL9.
CleanExi HS_ZNF333.
ExpressionAtlasi Q96JL9. baseline and differential.
Genevestigatori Q96JL9.

Family and domain databases

Gene3Di 3.30.160.60. 10 hits.
InterProi IPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view ]
Pfami PF01352. KRAB. 2 hits.
PF00096. zf-C2H2. 2 hits.
[Graphical view ]
SMARTi SM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 10 hits.
[Graphical view ]
SUPFAMi SSF109640. SSF109640. 1 hit.
PROSITEi PS50805. KRAB. 2 hits.
PS00028. ZINC_FINGER_C2H2_1. 10 hits.
PS50157. ZINC_FINGER_C2H2_2. 10 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of ZNF333, a novel double KRAB domain containing zinc finger gene on human chromosome 19p13.1."
    Tian Y., Breedveld G.J., Huang S., Oostra B.A., Heutink P., Lo W.H.Y.
    Biochim. Biophys. Acta 1577:121-125(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Brain.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
    Tissue: Ovary and Testis.
  4. "Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Nakayama M., Nakajima D., Kikuno R., Ohara O.
    DNA Res. 8:85-95(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 185-665 (ISOFORM 1).
    Tissue: Brain.

Entry informationi

Entry nameiZN333_HUMAN
AccessioniPrimary (citable) accession number: Q96JL9
Secondary accession number(s): Q6P2E6, Q86WS6, Q8TDL0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2002
Last sequence update: February 28, 2003
Last modified: October 29, 2014
This is version 114 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3