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Protein

Zinc finger protein 333

Gene

ZNF333

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri366 – 388C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri394 – 416C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri422 – 444C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri450 – 472C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri478 – 500C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri506 – 528C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri534 – 556C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri562 – 584C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri590 – 612C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri618 – 640C2H2-type 10PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:ENSG00000160961-MONOMER.
ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 333
Gene namesi
Name:ZNF333
Synonyms:KIAA1806
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:15624. ZNF333.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000160961.
PharmGKBiPA134929553.

Polymorphism and mutation databases

BioMutaiZNF333.
DMDMi29840870.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000475361 – 665Zinc finger protein 333Add BLAST665

Proteomic databases

EPDiQ96JL9.
PaxDbiQ96JL9.
PeptideAtlasiQ96JL9.
PRIDEiQ96JL9.

PTM databases

iPTMnetiQ96JL9.
PhosphoSitePlusiQ96JL9.

Expressioni

Tissue specificityi

Highly expressed in heart.

Gene expression databases

BgeeiENSG00000160961.
CleanExiHS_ZNF333.
ExpressionAtlasiQ96JL9. baseline and differential.
GenevisibleiQ96JL9. HS.

Organism-specific databases

HPAiHPA043973.

Interactioni

Protein-protein interaction databases

BioGridi124087. 6 interactors.
IntActiQ96JL9. 2 interactors.
MINTiMINT-8417739.
STRINGi9606.ENSP00000292530.

Structurei

3D structure databases

ProteinModelPortaliQ96JL9.
SMRiQ96JL9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 74KRAB 1PROSITE-ProRule annotationAdd BLAST71
Domaini203 – 274KRAB 2PROSITE-ProRule annotationAdd BLAST72

Sequence similaritiesi

Contains 10 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 2 KRAB domains.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri366 – 388C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri394 – 416C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri422 – 444C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri450 – 472C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri478 – 500C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri506 – 528C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri534 – 556C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri562 – 584C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri590 – 612C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri618 – 640C2H2-type 10PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129830.
HOGENOMiHOG000143390.
HOVERGENiHBG018163.
InParanoidiQ96JL9.
KOiK09228.
OMAiFQYQRIH.
OrthoDBiEOG091G02KC.
PhylomeDBiQ96JL9.
TreeFamiTF350814.

Family and domain databases

CDDicd07765. KRAB_A-box. 2 hits.
Gene3Di3.30.160.60. 10 hits.
InterProiIPR001909. KRAB.
IPR003656. Znf_BED.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 2 hits.
PF00096. zf-C2H2. 3 hits.
PF13912. zf-C2H2_6. 1 hit.
PF13465. zf-H2C2_2. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 2 hits.
SM00614. ZnF_BED. 2 hits.
SM00355. ZnF_C2H2. 10 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 2 hits.
PROSITEiPS50805. KRAB. 2 hits.
PS00028. ZINC_FINGER_C2H2_1. 10 hits.
PS50157. ZINC_FINGER_C2H2_2. 10 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96JL9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MESVTFEDVA VEFIQEWALL DSARRSLCKY RMLDQCRTLA SRGTPPCKPS
60 70 80 90 100
CVSQLGQRAE PKATERGILR ATGVAWESQL KPEELPSMQD LLEEASSRDM
110 120 130 140 150
QMGPGLFLRM QLVPSIEERE TPLTREDRPA LQEPPWSLGC TGLKAAMQIQ
160 170 180 190 200
RVVIPVPTLG HRNPWVARDS AVPARDPAWL QEDKVEEEAM APGLPTACSQ
210 220 230 240 250
EPVTFADVAV VFTPEEWVFL DSTQRSLYRD VMLENYRNLA SVADQLCKPN
260 270 280 290 300
ALSYLEERGE QWTTDRGVLS DTCAEPQCQP QEAIPSQDTF TEILSIDVKG
310 320 330 340 350
EQPQPGEKLY KYNELEKPFN SIEPLFQYQR IHAGEASCEC QEIRNSFFQS
360 370 380 390 400
AHLIVPEKIR SGDKSYACNK CEKSFRYSSD LIRHEKTHTA EKCFDCQECG
410 420 430 440 450
QAFKYSSNLR RHMRTHTGEK PFECSQCGKT FTRNFNLILH QRNHTGEKPY
460 470 480 490 500
ECKDCGKAFN QPSSLRSHVR THTGEKPFEC SQCGKAFREH SSLKTHLRTH
510 520 530 540 550
TREKPYECNQ CGKPFRTSTH LNVHKRIHTG EKLYECATCG QVLSRLSTLK
560 570 580 590 600
SHMRTHTGEK PYVCQECGRA FSEPSSLRKH ARTHSGKKPY ACQECGRAFG
610 620 630 640 650
QSSHLIVHVR THSAGRPYQC NQCEKAFRHS SSLTVHKRTH VGRETIRNGS
660
LPLSMSHPYC GPLAN
Length:665
Mass (Da):75,544
Last modified:February 28, 2003 - v3
Checksum:iEE5ABF8468D8DD24
GO
Isoform 2 (identifier: Q96JL9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     142-182: GLKAAMQIQR...PARDPAWLQE → LPLLSLLLPS...TLDTEARGIP
     183-665: Missing.

Show »
Length:182
Mass (Da):20,198
Checksum:i59AB52A753D4954E
GO
Isoform 3 (identifier: Q96JL9-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     301-302: EQ → PPN
     303-665: Missing.

Note: No experimental confirmation available.
Show »
Length:303
Mass (Da):33,917
Checksum:i0948D4793CC59D4C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti115S → P in AAH48107 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_024210251A → E.Corresponds to variant rs3885179dbSNPEnsembl.1
Natural variantiVAR_052812537A → V.Corresponds to variant rs3764626dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_055945142 – 182GLKAA…AWLQE → LPLLSLLLPSCPEPPLVLLD SSSAPDRHLGSTLDTEARGI P in isoform 2. 2 PublicationsAdd BLAST41
Alternative sequenceiVSP_055946183 – 665Missing in isoform 2. 2 PublicationsAdd BLAST483
Alternative sequenceiVSP_055947301 – 302EQ → PPN in isoform 3. 1 Publication2
Alternative sequenceiVSP_055948303 – 665Missing in isoform 3. 1 PublicationAdd BLAST363

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF372702 mRNA. Translation: AAM15528.1.
AK291471 mRNA. Translation: BAF84160.1.
BC048107 mRNA. Translation: AAH48107.1.
BC064571 mRNA. Translation: AAH64571.1.
AB058709 mRNA. Translation: BAB47435.1.
CCDSiCCDS12316.1. [Q96JL9-1]
CCDS74298.1. [Q96JL9-3]
RefSeqiNP_001287841.1. NM_001300912.1. [Q96JL9-3]
NP_115809.1. NM_032433.2. [Q96JL9-1]
XP_011526664.1. XM_011528362.2. [Q96JL9-1]
XP_016882856.1. XM_017027367.1. [Q96JL9-1]
UniGeneiHs.515215.

Genome annotation databases

EnsembliENST00000292530; ENSP00000292530; ENSG00000160961. [Q96JL9-1]
ENST00000540689; ENSP00000438130; ENSG00000160961. [Q96JL9-3]
GeneIDi84449.
KEGGihsa:84449.
UCSCiuc002mzn.4. human. [Q96JL9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF372702 mRNA. Translation: AAM15528.1.
AK291471 mRNA. Translation: BAF84160.1.
BC048107 mRNA. Translation: AAH48107.1.
BC064571 mRNA. Translation: AAH64571.1.
AB058709 mRNA. Translation: BAB47435.1.
CCDSiCCDS12316.1. [Q96JL9-1]
CCDS74298.1. [Q96JL9-3]
RefSeqiNP_001287841.1. NM_001300912.1. [Q96JL9-3]
NP_115809.1. NM_032433.2. [Q96JL9-1]
XP_011526664.1. XM_011528362.2. [Q96JL9-1]
XP_016882856.1. XM_017027367.1. [Q96JL9-1]
UniGeneiHs.515215.

3D structure databases

ProteinModelPortaliQ96JL9.
SMRiQ96JL9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124087. 6 interactors.
IntActiQ96JL9. 2 interactors.
MINTiMINT-8417739.
STRINGi9606.ENSP00000292530.

PTM databases

iPTMnetiQ96JL9.
PhosphoSitePlusiQ96JL9.

Polymorphism and mutation databases

BioMutaiZNF333.
DMDMi29840870.

Proteomic databases

EPDiQ96JL9.
PaxDbiQ96JL9.
PeptideAtlasiQ96JL9.
PRIDEiQ96JL9.

Protocols and materials databases

DNASUi84449.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000292530; ENSP00000292530; ENSG00000160961. [Q96JL9-1]
ENST00000540689; ENSP00000438130; ENSG00000160961. [Q96JL9-3]
GeneIDi84449.
KEGGihsa:84449.
UCSCiuc002mzn.4. human. [Q96JL9-1]

Organism-specific databases

CTDi84449.
GeneCardsiZNF333.
HGNCiHGNC:15624. ZNF333.
HPAiHPA043973.
MIMi611811. gene.
neXtProtiNX_Q96JL9.
OpenTargetsiENSG00000160961.
PharmGKBiPA134929553.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129830.
HOGENOMiHOG000143390.
HOVERGENiHBG018163.
InParanoidiQ96JL9.
KOiK09228.
OMAiFQYQRIH.
OrthoDBiEOG091G02KC.
PhylomeDBiQ96JL9.
TreeFamiTF350814.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000160961-MONOMER.
ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

ChiTaRSiZNF333. human.
GenomeRNAii84449.
PROiQ96JL9.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000160961.
CleanExiHS_ZNF333.
ExpressionAtlasiQ96JL9. baseline and differential.
GenevisibleiQ96JL9. HS.

Family and domain databases

CDDicd07765. KRAB_A-box. 2 hits.
Gene3Di3.30.160.60. 10 hits.
InterProiIPR001909. KRAB.
IPR003656. Znf_BED.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 2 hits.
PF00096. zf-C2H2. 3 hits.
PF13912. zf-C2H2_6. 1 hit.
PF13465. zf-H2C2_2. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 2 hits.
SM00614. ZnF_BED. 2 hits.
SM00355. ZnF_C2H2. 10 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 2 hits.
PROSITEiPS50805. KRAB. 2 hits.
PS00028. ZINC_FINGER_C2H2_1. 10 hits.
PS50157. ZINC_FINGER_C2H2_2. 10 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZN333_HUMAN
AccessioniPrimary (citable) accession number: Q96JL9
Secondary accession number(s): Q6P2E6, Q86WS6, Q8TDL0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2002
Last sequence update: February 28, 2003
Last modified: November 2, 2016
This is version 133 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.