Q96JL9 (ZN333_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Zinc finger protein 333

Gene names

Name:	ZNF333
Synonyms:	KIAA1806

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	665 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May be involved in transcriptional regulation.
Subcellular location	Nucleus Probable.
Tissue specificity	Highly expressed in heart.
Sequence similarities	Belongs to the krueppel C2H2-type zinc-finger protein family. Contains 10 C2H2-type zinc fingers. Contains 2 KRAB domains.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Coding sequence diversity	Polymorphism
Domain	Repeat Zinc-finger
Ligand	DNA-binding Metal-binding Zinc
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 665	665	Zinc finger protein 333		PRO_0000047536
Regions
	Domain	4 – 74	71	KRAB 1
	Domain	203 – 274	72	KRAB 2
	Zinc finger	366 – 388	23	C2H2-type 1
	Zinc finger	394 – 416	23	C2H2-type 2
	Zinc finger	422 – 444	23	C2H2-type 3
	Zinc finger	450 – 472	23	C2H2-type 4
	Zinc finger	478 – 500	23	C2H2-type 5
	Zinc finger	506 – 528	23	C2H2-type 6
	Zinc finger	534 – 556	23	C2H2-type 7
	Zinc finger	562 – 584	23	C2H2-type 8
	Zinc finger	590 – 612	23	C2H2-type 9
	Zinc finger	618 – 640	23	C2H2-type 10
Natural variations
	Natural variant	251	1	A → E. Corresponds to variant rs3885179 [ dbSNP | Ensembl ].		VAR_024210
	Natural variant	537	1	A → V. Corresponds to variant rs3764626 [ dbSNP | Ensembl ].		VAR_052812

Sequences

	Sequence		Length	Mass (Da)
	Q96JL9 [UniParc]. Last modified February 28, 2003. Version 3. Checksum: EE5ABF8468D8DD24	FASTA	665	75,544
	10 20 30 40 50 60 MESVTFEDVA VEFIQEWALL DSARRSLCKY RMLDQCRTLA SRGTPPCKPS CVSQLGQRAE 70 80 90 100 110 120 PKATERGILR ATGVAWESQL KPEELPSMQD LLEEASSRDM QMGPGLFLRM QLVPSIEERE 130 140 150 160 170 180 TPLTREDRPA LQEPPWSLGC TGLKAAMQIQ RVVIPVPTLG HRNPWVARDS AVPARDPAWL 190 200 210 220 230 240 QEDKVEEEAM APGLPTACSQ EPVTFADVAV VFTPEEWVFL DSTQRSLYRD VMLENYRNLA 250 260 270 280 290 300 SVADQLCKPN ALSYLEERGE QWTTDRGVLS DTCAEPQCQP QEAIPSQDTF TEILSIDVKG 310 320 330 340 350 360 EQPQPGEKLY KYNELEKPFN SIEPLFQYQR IHAGEASCEC QEIRNSFFQS AHLIVPEKIR 370 380 390 400 410 420 SGDKSYACNK CEKSFRYSSD LIRHEKTHTA EKCFDCQECG QAFKYSSNLR RHMRTHTGEK 430 440 450 460 470 480 PFECSQCGKT FTRNFNLILH QRNHTGEKPY ECKDCGKAFN QPSSLRSHVR THTGEKPFEC 490 500 510 520 530 540 SQCGKAFREH SSLKTHLRTH TREKPYECNQ CGKPFRTSTH LNVHKRIHTG EKLYECATCG 550 560 570 580 590 600 QVLSRLSTLK SHMRTHTGEK PYVCQECGRA FSEPSSLRKH ARTHSGKKPY ACQECGRAFG 610 620 630 640 650 660 QSSHLIVHVR THSAGRPYQC NQCEKAFRHS SSLTVHKRTH VGRETIRNGS LPLSMSHPYC GPLAN

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Characterization of ZNF333, a novel double KRAB domain containing zinc finger gene on human chromosome 19p13.1." Tian Y., Breedveld G.J., Huang S., Oostra B.A., Heutink P., Lo W.H.Y. Biochim. Biophys. Acta 1577:121-125(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Nakayama M., Nakajima D., Kikuno R., Ohara O. DNA Res. 8:85-95(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 185-665. Tissue: Brain.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF372702 mRNA. Translation: AAM15528.1. AB058709 mRNA. Translation: BAB47435.1.
IPI	IPI00064209.
RefSeq	NP_115809.1. NM_032433.2.
UniGene	Hs.515215.
3D structure databases
ProteinModelPortal	Q96JL9.
ModBase	Search...
PTM databases
PhosphoSite	Q96JL9.
Polymorphism databases
DMDM	29840870.
Proteomic databases
PaxDb	Q96JL9.
PRIDE	Q96JL9.
Protocols and materials databases
DNASU	84449.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000292530; ENSP00000292530; ENSG00000160961.
GeneID	84449.
KEGG	hsa:84449.
UCSC	uc002mzk.4. human.
Organism-specific databases
CTD	84449.
GeneCards	GC19P014800.
HGNC	HGNC:15624. ZNF333.
HPA	HPA043973.
MIM	611811. gene.
neXtProt	NX_Q96JL9.
PharmGKB	PA134929553.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG5048.
HOGENOM	HOG000234617.
HOVERGEN	HBG018163.
InParanoid	Q96JL9.
KO	K09228.
OMA	YACNKCE.
OrthoDB	EOG4320XR.
PhylomeDB	Q96JL9.
Enzyme and pathway databases
Reactome	REACT_71. Gene Expression.
Gene expression databases
ArrayExpress	Q96JL9.
Bgee	Q96JL9.
CleanEx	HS_ZNF333.
Genevestigator	Q96JL9.
GermOnline	ENSG00000160961. Homo sapiens.
Family and domain databases
Gene3D	3.30.160.60. 10 hits.
InterPro	IPR001909. Krueppel-associated_box. IPR007087. Znf_C2H2. IPR015880. Znf_C2H2-like. IPR013087. Znf_C2H2/integrase_DNA-bd. [Graphical view]
Pfam	PF01352. KRAB. 2 hits. PF00096. zf-C2H2. 2 hits. [Graphical view]
SMART	SM00349. KRAB. 2 hits. SM00355. ZnF_C2H2. 10 hits. [Graphical view]
SUPFAM	SSF109640. Krueppel-associated_box. 2 hits.
PROSITE	PS50805. KRAB. 2 hits. PS00028. ZINC_FINGER_C2H2_1. 10 hits. PS50157. ZINC_FINGER_C2H2_2. 10 hits. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	ZNF333. human.
GenomeRNAi	84449.
NextBio	74227.
SOURCE	Search...

Entry information

Entry name

ZN333_HUMAN

Accession

Primary (citable) accession number: Q96JL9
Secondary accession number(s): Q8TDL0

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 21, 2002
Last sequence update:	February 28, 2003
Last modified:	May 1, 2013
This is version 101 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.