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Q96JL9

- ZN333_HUMAN

UniProt

Q96JL9 - ZN333_HUMAN

Protein

Zinc finger protein 333

Gene

ZNF333

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 113 (01 Oct 2014)
      Sequence version 3 (28 Feb 2003)
      Previous versions | rss
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    Functioni

    May be involved in transcriptional regulation.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri366 – 38823C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri394 – 41623C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri422 – 44423C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri450 – 47223C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri478 – 50023C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri506 – 52823C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri534 – 55623C2H2-type 7PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri562 – 58423C2H2-type 8PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri590 – 61223C2H2-type 9PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri618 – 64023C2H2-type 10PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. regulation of transcription, DNA-templated Source: UniProtKB-KW
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Enzyme and pathway databases

    ReactomeiREACT_12627. Generic Transcription Pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Zinc finger protein 333
    Gene namesi
    Name:ZNF333
    Synonyms:KIAA1806
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:15624. ZNF333.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134929553.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 665665Zinc finger protein 333PRO_0000047536Add
    BLAST

    Proteomic databases

    PaxDbiQ96JL9.
    PRIDEiQ96JL9.

    PTM databases

    PhosphoSiteiQ96JL9.

    Expressioni

    Tissue specificityi

    Highly expressed in heart.

    Gene expression databases

    ArrayExpressiQ96JL9.
    BgeeiQ96JL9.
    CleanExiHS_ZNF333.
    GenevestigatoriQ96JL9.

    Organism-specific databases

    HPAiHPA043973.

    Interactioni

    Protein-protein interaction databases

    BioGridi124087. 1 interaction.
    IntActiQ96JL9. 1 interaction.
    MINTiMINT-8417739.

    Structurei

    3D structure databases

    ProteinModelPortaliQ96JL9.
    SMRiQ96JL9. Positions 203-243, 304-646.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini4 – 7471KRAB 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini203 – 27472KRAB 2PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 10 C2H2-type zinc fingers.PROSITE-ProRule annotation
    Contains 2 KRAB domains.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri366 – 38823C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri394 – 41623C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri422 – 44423C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri450 – 47223C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri478 – 50023C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri506 – 52823C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri534 – 55623C2H2-type 7PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri562 – 58423C2H2-type 8PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri590 – 61223C2H2-type 9PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri618 – 64023C2H2-type 10PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG5048.
    HOGENOMiHOG000234617.
    HOVERGENiHBG018163.
    InParanoidiQ96JL9.
    KOiK09228.
    OMAiYACNKCE.
    PhylomeDBiQ96JL9.
    TreeFamiTF350814.

    Family and domain databases

    Gene3Di3.30.160.60. 10 hits.
    InterProiIPR001909. Krueppel-associated_box.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view]
    PfamiPF01352. KRAB. 2 hits.
    PF00096. zf-C2H2. 2 hits.
    [Graphical view]
    SMARTiSM00349. KRAB. 2 hits.
    SM00355. ZnF_C2H2. 10 hits.
    [Graphical view]
    SUPFAMiSSF109640. SSF109640. 2 hits.
    PROSITEiPS50805. KRAB. 2 hits.
    PS00028. ZINC_FINGER_C2H2_1. 10 hits.
    PS50157. ZINC_FINGER_C2H2_2. 10 hits.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q96JL9-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MESVTFEDVA VEFIQEWALL DSARRSLCKY RMLDQCRTLA SRGTPPCKPS    50
    CVSQLGQRAE PKATERGILR ATGVAWESQL KPEELPSMQD LLEEASSRDM 100
    QMGPGLFLRM QLVPSIEERE TPLTREDRPA LQEPPWSLGC TGLKAAMQIQ 150
    RVVIPVPTLG HRNPWVARDS AVPARDPAWL QEDKVEEEAM APGLPTACSQ 200
    EPVTFADVAV VFTPEEWVFL DSTQRSLYRD VMLENYRNLA SVADQLCKPN 250
    ALSYLEERGE QWTTDRGVLS DTCAEPQCQP QEAIPSQDTF TEILSIDVKG 300
    EQPQPGEKLY KYNELEKPFN SIEPLFQYQR IHAGEASCEC QEIRNSFFQS 350
    AHLIVPEKIR SGDKSYACNK CEKSFRYSSD LIRHEKTHTA EKCFDCQECG 400
    QAFKYSSNLR RHMRTHTGEK PFECSQCGKT FTRNFNLILH QRNHTGEKPY 450
    ECKDCGKAFN QPSSLRSHVR THTGEKPFEC SQCGKAFREH SSLKTHLRTH 500
    TREKPYECNQ CGKPFRTSTH LNVHKRIHTG EKLYECATCG QVLSRLSTLK 550
    SHMRTHTGEK PYVCQECGRA FSEPSSLRKH ARTHSGKKPY ACQECGRAFG 600
    QSSHLIVHVR THSAGRPYQC NQCEKAFRHS SSLTVHKRTH VGRETIRNGS 650
    LPLSMSHPYC GPLAN 665
    Length:665
    Mass (Da):75,544
    Last modified:February 28, 2003 - v3
    Checksum:iEE5ABF8468D8DD24
    GO
    Isoform 2 (identifier: Q96JL9-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         142-182: GLKAAMQIQR...PARDPAWLQE → LPLLSLLLPS...TLDTEARGIP
         183-665: Missing.

    Show »
    Length:182
    Mass (Da):20,198
    Checksum:i59AB52A753D4954E
    GO
    Isoform 3 (identifier: Q96JL9-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         301-302: EQ → PPN
         303-665: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:303
    Mass (Da):33,917
    Checksum:i0948D4793CC59D4C
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti115 – 1151S → P in AAH48107. (PubMed:15489334)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti251 – 2511A → E.
    Corresponds to variant rs3885179 [ dbSNP | Ensembl ].
    VAR_024210
    Natural varianti537 – 5371A → V.
    Corresponds to variant rs3764626 [ dbSNP | Ensembl ].
    VAR_052812

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei142 – 18241GLKAA…AWLQE → LPLLSLLLPSCPEPPLVLLD SSSAPDRHLGSTLDTEARGI P in isoform 2. 2 PublicationsVSP_055945Add
    BLAST
    Alternative sequencei183 – 665483Missing in isoform 2. 2 PublicationsVSP_055946Add
    BLAST
    Alternative sequencei301 – 3022EQ → PPN in isoform 3. 1 PublicationVSP_055947
    Alternative sequencei303 – 665363Missing in isoform 3. 1 PublicationVSP_055948Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF372702 mRNA. Translation: AAM15528.1.
    AK291471 mRNA. Translation: BAF84160.1.
    BC048107 mRNA. Translation: AAH48107.1.
    BC064571 mRNA. Translation: AAH64571.1.
    AB058709 mRNA. Translation: BAB47435.1.
    CCDSiCCDS12316.1.
    RefSeqiNP_115809.1. NM_032433.2.
    UniGeneiHs.515215.

    Genome annotation databases

    EnsembliENST00000292530; ENSP00000292530; ENSG00000160961.
    GeneIDi84449.
    KEGGihsa:84449.
    UCSCiuc002mzk.4. human.

    Polymorphism databases

    DMDMi29840870.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF372702 mRNA. Translation: AAM15528.1 .
    AK291471 mRNA. Translation: BAF84160.1 .
    BC048107 mRNA. Translation: AAH48107.1 .
    BC064571 mRNA. Translation: AAH64571.1 .
    AB058709 mRNA. Translation: BAB47435.1 .
    CCDSi CCDS12316.1.
    RefSeqi NP_115809.1. NM_032433.2.
    UniGenei Hs.515215.

    3D structure databases

    ProteinModelPortali Q96JL9.
    SMRi Q96JL9. Positions 203-243, 304-646.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 124087. 1 interaction.
    IntActi Q96JL9. 1 interaction.
    MINTi MINT-8417739.

    PTM databases

    PhosphoSitei Q96JL9.

    Polymorphism databases

    DMDMi 29840870.

    Proteomic databases

    PaxDbi Q96JL9.
    PRIDEi Q96JL9.

    Protocols and materials databases

    DNASUi 84449.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000292530 ; ENSP00000292530 ; ENSG00000160961 .
    GeneIDi 84449.
    KEGGi hsa:84449.
    UCSCi uc002mzk.4. human.

    Organism-specific databases

    CTDi 84449.
    GeneCardsi GC19P014800.
    HGNCi HGNC:15624. ZNF333.
    HPAi HPA043973.
    MIMi 611811. gene.
    neXtProti NX_Q96JL9.
    PharmGKBi PA134929553.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5048.
    HOGENOMi HOG000234617.
    HOVERGENi HBG018163.
    InParanoidi Q96JL9.
    KOi K09228.
    OMAi YACNKCE.
    PhylomeDBi Q96JL9.
    TreeFami TF350814.

    Enzyme and pathway databases

    Reactomei REACT_12627. Generic Transcription Pathway.

    Miscellaneous databases

    ChiTaRSi ZNF333. human.
    GenomeRNAii 84449.
    NextBioi 74227.
    PROi Q96JL9.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q96JL9.
    Bgeei Q96JL9.
    CleanExi HS_ZNF333.
    Genevestigatori Q96JL9.

    Family and domain databases

    Gene3Di 3.30.160.60. 10 hits.
    InterProi IPR001909. Krueppel-associated_box.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view ]
    Pfami PF01352. KRAB. 2 hits.
    PF00096. zf-C2H2. 2 hits.
    [Graphical view ]
    SMARTi SM00349. KRAB. 2 hits.
    SM00355. ZnF_C2H2. 10 hits.
    [Graphical view ]
    SUPFAMi SSF109640. SSF109640. 2 hits.
    PROSITEi PS50805. KRAB. 2 hits.
    PS00028. ZINC_FINGER_C2H2_1. 10 hits.
    PS50157. ZINC_FINGER_C2H2_2. 10 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Characterization of ZNF333, a novel double KRAB domain containing zinc finger gene on human chromosome 19p13.1."
      Tian Y., Breedveld G.J., Huang S., Oostra B.A., Heutink P., Lo W.H.Y.
      Biochim. Biophys. Acta 1577:121-125(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Brain.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
      Tissue: Ovary and Testis.
    4. "Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
      Nagase T., Nakayama M., Nakajima D., Kikuno R., Ohara O.
      DNA Res. 8:85-95(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 185-665 (ISOFORM 1).
      Tissue: Brain.

    Entry informationi

    Entry nameiZN333_HUMAN
    AccessioniPrimary (citable) accession number: Q96JL9
    Secondary accession number(s): Q6P2E6, Q86WS6, Q8TDL0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 21, 2002
    Last sequence update: February 28, 2003
    Last modified: October 1, 2014
    This is version 113 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3