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Q96JL9 (ZN333_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 111. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Zinc finger protein 333
Gene names
Name:ZNF333
Synonyms:KIAA1806
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length665 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May be involved in transcriptional regulation.

Subcellular location

Nucleus Probable.

Tissue specificity

Highly expressed in heart.

Sequence similarities

Belongs to the krueppel C2H2-type zinc-finger protein family.

Contains 10 C2H2-type zinc fingers.

Contains 2 KRAB domains.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   Coding sequence diversityPolymorphism
   DomainRepeat
Zinc-finger
   LigandDNA-binding
Metal-binding
Zinc
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processregulation of transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionDNA binding

Inferred from electronic annotation. Source: UniProtKB-KW

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 665665Zinc finger protein 333
PRO_0000047536

Regions

Domain4 – 7471KRAB 1
Domain203 – 27472KRAB 2
Zinc finger366 – 38823C2H2-type 1
Zinc finger394 – 41623C2H2-type 2
Zinc finger422 – 44423C2H2-type 3
Zinc finger450 – 47223C2H2-type 4
Zinc finger478 – 50023C2H2-type 5
Zinc finger506 – 52823C2H2-type 6
Zinc finger534 – 55623C2H2-type 7
Zinc finger562 – 58423C2H2-type 8
Zinc finger590 – 61223C2H2-type 9
Zinc finger618 – 64023C2H2-type 10

Natural variations

Natural variant2511A → E.
Corresponds to variant rs3885179 [ dbSNP | Ensembl ].
VAR_024210
Natural variant5371A → V.
Corresponds to variant rs3764626 [ dbSNP | Ensembl ].
VAR_052812

Sequences

Sequence LengthMass (Da)Tools
Q96JL9 [UniParc].

Last modified February 28, 2003. Version 3.
Checksum: EE5ABF8468D8DD24

FASTA66575,544
        10         20         30         40         50         60 
MESVTFEDVA VEFIQEWALL DSARRSLCKY RMLDQCRTLA SRGTPPCKPS CVSQLGQRAE 

        70         80         90        100        110        120 
PKATERGILR ATGVAWESQL KPEELPSMQD LLEEASSRDM QMGPGLFLRM QLVPSIEERE 

       130        140        150        160        170        180 
TPLTREDRPA LQEPPWSLGC TGLKAAMQIQ RVVIPVPTLG HRNPWVARDS AVPARDPAWL 

       190        200        210        220        230        240 
QEDKVEEEAM APGLPTACSQ EPVTFADVAV VFTPEEWVFL DSTQRSLYRD VMLENYRNLA 

       250        260        270        280        290        300 
SVADQLCKPN ALSYLEERGE QWTTDRGVLS DTCAEPQCQP QEAIPSQDTF TEILSIDVKG 

       310        320        330        340        350        360 
EQPQPGEKLY KYNELEKPFN SIEPLFQYQR IHAGEASCEC QEIRNSFFQS AHLIVPEKIR 

       370        380        390        400        410        420 
SGDKSYACNK CEKSFRYSSD LIRHEKTHTA EKCFDCQECG QAFKYSSNLR RHMRTHTGEK 

       430        440        450        460        470        480 
PFECSQCGKT FTRNFNLILH QRNHTGEKPY ECKDCGKAFN QPSSLRSHVR THTGEKPFEC 

       490        500        510        520        530        540 
SQCGKAFREH SSLKTHLRTH TREKPYECNQ CGKPFRTSTH LNVHKRIHTG EKLYECATCG 

       550        560        570        580        590        600 
QVLSRLSTLK SHMRTHTGEK PYVCQECGRA FSEPSSLRKH ARTHSGKKPY ACQECGRAFG 

       610        620        630        640        650        660 
QSSHLIVHVR THSAGRPYQC NQCEKAFRHS SSLTVHKRTH VGRETIRNGS LPLSMSHPYC 


GPLAN 

« Hide

References

« Hide 'large scale' references
[1]"Characterization of ZNF333, a novel double KRAB domain containing zinc finger gene on human chromosome 19p13.1."
Tian Y., Breedveld G.J., Huang S., Oostra B.A., Heutink P., Lo W.H.Y.
Biochim. Biophys. Acta 1577:121-125(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
Nagase T., Nakayama M., Nakajima D., Kikuno R., Ohara O.
DNA Res. 8:85-95(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 185-665.
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF372702 mRNA. Translation: AAM15528.1.
AB058709 mRNA. Translation: BAB47435.1.
CCDSCCDS12316.1.
RefSeqNP_115809.1. NM_032433.2.
UniGeneHs.515215.

3D structure databases

ProteinModelPortalQ96JL9.
SMRQ96JL9. Positions 203-243, 304-646.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid124087. 1 interaction.
IntActQ96JL9. 1 interaction.
MINTMINT-8417739.

PTM databases

PhosphoSiteQ96JL9.

Polymorphism databases

DMDM29840870.

Proteomic databases

PaxDbQ96JL9.
PRIDEQ96JL9.

Protocols and materials databases

DNASU84449.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000292530; ENSP00000292530; ENSG00000160961.
GeneID84449.
KEGGhsa:84449.
UCSCuc002mzk.4. human.

Organism-specific databases

CTD84449.
GeneCardsGC19P014800.
HGNCHGNC:15624. ZNF333.
HPAHPA043973.
MIM611811. gene.
neXtProtNX_Q96JL9.
PharmGKBPA134929553.
HUGESearch...
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5048.
HOGENOMHOG000234617.
HOVERGENHBG018163.
InParanoidQ96JL9.
KOK09228.
OMAYACNKCE.
PhylomeDBQ96JL9.
TreeFamTF350814.

Enzyme and pathway databases

ReactomeREACT_71. Gene Expression.

Gene expression databases

ArrayExpressQ96JL9.
BgeeQ96JL9.
CleanExHS_ZNF333.
GenevestigatorQ96JL9.

Family and domain databases

Gene3D3.30.160.60. 10 hits.
InterProIPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamPF01352. KRAB. 2 hits.
PF00096. zf-C2H2. 2 hits.
[Graphical view]
SMARTSM00349. KRAB. 2 hits.
SM00355. ZnF_C2H2. 10 hits.
[Graphical view]
SUPFAMSSF109640. SSF109640. 2 hits.
PROSITEPS50805. KRAB. 2 hits.
PS00028. ZINC_FINGER_C2H2_1. 10 hits.
PS50157. ZINC_FINGER_C2H2_2. 10 hits.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSZNF333. human.
GenomeRNAi84449.
NextBio74227.
PROQ96JL9.
SOURCESearch...

Entry information

Entry nameZN333_HUMAN
AccessionPrimary (citable) accession number: Q96JL9
Secondary accession number(s): Q8TDL0
Entry history
Integrated into UniProtKB/Swiss-Prot: February 21, 2002
Last sequence update: February 28, 2003
Last modified: July 9, 2014
This is version 111 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM