Q96JK4 (HIPL1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
HHIP-like protein 1

Gene names

Name:	HHIPL1
Synonyms:	HHIP2, KIAA1822
ORF Names:	UNQ9245/PRO34761

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	782 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subcellular location	Secreted Potential.
Sequence similarities	Belongs to the HHIP family. Contains 1 SRCR domain.

Ontologies

Keywords
Cellular component	Secreted
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Signal
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	carbohydrate metabolic process Inferred from electronic annotation. Source: InterPro
Cellular_component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell membrane Inferred from electronic annotation. Source: InterPro
Molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor Inferred from electronic annotation. Source: InterPro quinone binding Inferred from electronic annotation. Source: InterPro scavenger receptor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q96JK4-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q96JK4-2)

The sequence of this isoform differs from the canonical sequence as follows:
     577-608: RRAPPGKCQIQPAQVKIRSRLIPFVPKEKFIP → SCKARSAMPGYVPAPSVCSSLTSQPFILQWWK
     609-782: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 19	19	Potential
	Chain	20 – 782	763	HHIP-like protein 1		PRO_0000314962
Regions
	Domain	673 – 776	104	SRCR
Amino acid modifications
	Glycosylation	234	1	N-linked (GlcNAc...) Potential
	Disulfide bond	181 ↔ 521		By similarity
	Disulfide bond	185 ↔ 528		By similarity
	Disulfide bond	399 ↔ 417		By similarity
	Disulfide bond	484 ↔ 584		By similarity
	Disulfide bond	700 ↔ 765		By similarity
	Disulfide bond	713 ↔ 775		By similarity
	Disulfide bond	745 ↔ 755		By similarity
Natural variations
	Alternative sequence	577 – 608	32	RRAPP…EKFIP → SCKARSAMPGYVPAPSVCSS LTSQPFILQWWK in isoform 2.		VSP_030455
	Alternative sequence	609 – 782	174	Missing in isoform 2.		VSP_030456
	Natural variant	692	1	V → A. Corresponds to variant rs7158073 [ dbSNP | Ensembl ].		VAR_060163
Experimental info
	Sequence conflict	151	1	L → M in AAQ88540. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified January 15, 2008. Version 2. Checksum: 5A6170845C6F9472	FASTA	782	86,731
	10 20 30 40 50 60 MARARAGALL ALWVLGAAAH PQCLDFRPPF RPTQPLRLCA QYSDFGCCDE GRDAELTRRF 70 80 90 100 110 120 WALASRVDAA EWAACAGYAR DLLCQECSPY AAHLYDAEDP FTPLRTVPGL CQDYCLDMWH 130 140 150 160 170 180 KCRGLFRHLS TDQELWALEG NLARFCRYLS LDDTDYCFPY LLVNKNLNSN LGHVVADAKG 190 200 210 220 230 240 CLQLCLEEVA NGLRNPVAMV HARDGTHRFF VAEQVGLVWA YLPDRSRLGK PFLNISRVVL 250 260 270 280 290 300 TSPWEGDERG FLGIAFHPSF QHNRRLYVYY SVGIRSSEWI RISEFRVSED DENAVDHSSE 310 320 330 340 350 360 RIILEVKEPA SNHNGGQLLF GDDGYLYIFT GDGGMAGDPF GTFGNAQNKS ALLGKVLRID 370 380 390 400 410 420 VDRKERGLPY GIPPDNPFVG DPAAQPEVYA LGVRNMWRCS FDRGDPSSGT GRGRLFCGDV 430 440 450 460 470 480 GQNKFEEVDV VERGGNYGWR AREGFECYDR SLCANTSLND LLPIFAYPHT VGKSVTGGYV 490 500 510 520 530 540 YRGCEYPNLN GLYIFGDFMS GRLMSLQENP GTGQWQYSEI CMGHGQTCEF PGLINNYYPY 550 560 570 580 590 600 IISFGEDEAG ELYFMSTGEP SATAPRGVVY KIIDASRRAP PGKCQIQPAQ VKIRSRLIPF 610 620 630 640 650 660 VPKEKFIPKT RSTPRPTARA PTRAPRRGRP TAAPPAPTPR PARPTQQPGS RRGGGRRRGR 670 680 690 700 710 720 LNSASRAFRD GEVRLVRPAG LSSGSGRVEV FVGGRWGTVC DDSWNISGAA VVCRQLGFAY 730 740 750 760 770 780 AVRAVKRAEF GQGGSLPILL DDVRCAGWER NLLECQHNGV GTHNCEHDED AGVVCSHQNP DL
	Isoform 2 [UniParc]. Checksum: 3FC5CDF759808D6B	FASTA	608	67,881
	10 20 30 40 50 60 MARARAGALL ALWVLGAAAH PQCLDFRPPF RPTQPLRLCA QYSDFGCCDE GRDAELTRRF 70 80 90 100 110 120 WALASRVDAA EWAACAGYAR DLLCQECSPY AAHLYDAEDP FTPLRTVPGL CQDYCLDMWH 130 140 150 160 170 180 KCRGLFRHLS TDQELWALEG NLARFCRYLS LDDTDYCFPY LLVNKNLNSN LGHVVADAKG 190 200 210 220 230 240 CLQLCLEEVA NGLRNPVAMV HARDGTHRFF VAEQVGLVWA YLPDRSRLGK PFLNISRVVL 250 260 270 280 290 300 TSPWEGDERG FLGIAFHPSF QHNRRLYVYY SVGIRSSEWI RISEFRVSED DENAVDHSSE 310 320 330 340 350 360 RIILEVKEPA SNHNGGQLLF GDDGYLYIFT GDGGMAGDPF GTFGNAQNKS ALLGKVLRID 370 380 390 400 410 420 VDRKERGLPY GIPPDNPFVG DPAAQPEVYA LGVRNMWRCS FDRGDPSSGT GRGRLFCGDV 430 440 450 460 470 480 GQNKFEEVDV VERGGNYGWR AREGFECYDR SLCANTSLND LLPIFAYPHT VGKSVTGGYV 490 500 510 520 530 540 YRGCEYPNLN GLYIFGDFMS GRLMSLQENP GTGQWQYSEI CMGHGQTCEF PGLINNYYPY 550 560 570 580 590 600 IISFGEDEAG ELYFMSTGEP SATAPRGVVY KIIDASSCKA RSAMPGYVPA PSVCSSLTSQ PFILQWWK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M. Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
[2]	"The DNA sequence and analysis of human chromosome 14." Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H. , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J. Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
[4]	"Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Nakayama M., Nakajima D., Kikuno R., Ohara O. DNA Res. 8:85-95(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 250-782 (ISOFORM 1). Tissue: Brain.
[5]	"Comparative genomics on HHIP family orthologs." Katoh Y., Katoh M. Int. J. Mol. Med. 17:391-395(2006) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION, NOMENCLATURE.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY358173 mRNA. Translation: AAQ88540.1. AL160313 Genomic DNA. No translation available. BC132877 mRNA. Translation: AAI32878.1. BC136577 mRNA. Translation: AAI36578.1. AB058725 mRNA. Translation: BAB47451.1.
IPI	IPI00477056. IPI00873374.
RefSeq	NP_001120730.1. NM_001127258.1. NP_115801.3. NM_032425.4.
UniGene	Hs.288522.
3D structure databases
HSSP	HSSP built from PDB template 1BY2 based on UniProtKB Q08380.
ProteinModelPortal	Q96JK4.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000330601.
PTM databases
PhosphoSite	Q96JK4.
Polymorphism databases
DMDM	166218135.
Proteomic databases
PaxDb	Q96JK4.
PRIDE	Q96JK4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000330710; ENSP00000330601; ENSG00000182218. ENST00000357223; ENSP00000349757; ENSG00000182218.
GeneID	84439.
KEGG	hsa:84439.
UCSC	uc001ygl.1. human. uc010avs.3. human.
Organism-specific databases
CTD	84439.
GeneCards	GC14P100111.
H-InvDB	HIX0011961. HIX0172357.
HGNC	HGNC:19710. HHIPL1.
HPA	HPA047242.
neXtProt	NX_Q96JK4.
PharmGKB	PA162390893.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG2133.
HOGENOM	HOG000244857.
HOVERGEN	HBG107978.
OMA	TDYCFPR.
OrthoDB	EOG4GHZNW.
Gene expression databases
ArrayExpress	Q96JK4.
Bgee	Q96JK4.
CleanEx	HS_HHIPL1.
Genevestigator	Q96JK4.
Family and domain databases
Gene3D	2.120.10.30. 1 hit.
InterPro	IPR011042. 6-blade_b-propeller_TolB-like. IPR018143. Folate_rcpt-like. IPR012938. Glc/Sorbosone_DH. IPR011041. Quinoprot_gluc/sorb_DH. IPR001190. Srcr_rcpt. IPR017448. Srcr_rcpt-rel. [Graphical view]
Pfam	PF03024. Folate_rec. 1 hit. PF07995. GSDH. 1 hit. PF00530. SRCR. 1 hit. [Graphical view]
PRINTS	PR00258. SPERACTRCPTR.
SMART	SM00202. SR. 1 hit. [Graphical view]
SUPFAM	SSF50952. Quino_gluc_DH. 1 hit. SSF56487. Srcr_receptor. 1 hit.
PROSITE	PS00420. SRCR_1. 1 hit. PS50287. SRCR_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	84439.
NextBio	74187.

Entry information

Entry name

HIPL1_HUMAN

Accession

Primary (citable) accession number: Q96JK4
Secondary accession number(s): A2RUF8, B2RN09, Q6UXX2

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	January 15, 2008
Last modified:	May 1, 2013
This is version 78 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.