Q96JH8 (RADIL_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ras-associating and dilute domain-containing protein

Gene names

Name:	RADIL
Synonyms:	KIAA1849

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1075 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Downstream effector of Rap required for cell adhesion and migration of neural crest precursors during development. Ref.9
Subunit structure	Interacts with RAP1A; in a GTP-dependent manner. Does not interact with members of the Ras family. Ref.9
Sequence similarities	Belongs to the RADIL family. Contains 1 dilute domain. Contains 1 FHA domain. Contains 1 PDZ (DHR) domain. Contains 1 Ras-associating domain.
Sequence caution	The sequence AAS07559.1 differs from that shown. Reason: Erroneous gene model prediction. The sequence BAA91543.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence BAB47478.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Ontologies

Keywords
Biological process	Cell adhesion
Coding sequence diversity	Alternative splicing Polymorphism
Molecular function	Developmental protein
PTM	Phosphoprotein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell adhesion Inferred from electronic annotation. Source: UniProtKB-KW multicellular organismal development Inferred from electronic annotation. Source: UniProtKB-KW signal transduction Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
ATIC	P31939	1	EBI-744267,EBI-1048599
CCNH	P51946	1	EBI-744267,EBI-741406
CDK2	P24941	1	EBI-744267,EBI-375096
RAD51L3	O75771	1	EBI-744267,EBI-1055693

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform 4 (identifier: Q96JH8-4)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q96JH8-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-495: Missing.

Note: No experimental confirmation available.

Isoform 3 (identifier: Q96JH8-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-704: Missing.
     705-763: ATPRAQLIQM...AQDSPEAFRS → MSPRVGPVTV...GHYGHPLSPA

Note: No experimental confirmation available.

Isoform 1 (identifier: Q96JH8-1)

The sequence of this isoform differs from the canonical sequence as follows:
     262-279: DSLVYVLNRDRHTVGQRT → PGVCAQPGPAHGGPAD

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 1075

1075

Ras-associating and dilute domain-containing protein

PRO_0000050803

Regions

Domain

61 – 164

104

Ras-associating

Domain

314 – 389

76

FHA

Domain

497 – 764

268

Dilute

Domain

976 – 1061

86

PDZ

Compositional bias

847 – 925

79

Pro-rich

Amino acid modifications

Modified residue

206

1

Phosphoserine By similarity

Natural variations

Alternative sequence

1 – 704

704

Missing in isoform 3.

VSP_016097

Alternative sequence

1 – 495

495

Missing in isoform 2.

VSP_016098

Alternative sequence

262 – 279

18

DSLVY…VGQRT → PGVCAQPGPAHGGPAD in isoform 1.

VSP_035179

Alternative sequence

705 – 763

59

ATPRA…EAFRS → MSPRVGPVTVARIPASCVHR AGDSGLNLLAPGFPHRWAGR PGEGGSFSCGHYGHPLSPA in isoform 3.

VSP_016099

Natural variant

239

1

D → N. Ref.1 Ref.3 Ref.11
Corresponds to variant rs3763384 [ dbSNP | Ensembl ].

VAR_046192

Natural variant

412

1

H → D. Ref.1 Ref.2 Ref.3
Corresponds to variant rs2292498 [ dbSNP | Ensembl ].

VAR_046193

Natural variant

886

1

S → G. Ref.1 Ref.2 Ref.3 Ref.5 Ref.6 Ref.7 Ref.8
Corresponds to variant rs414035 [ dbSNP | Ensembl ].

VAR_023769

Natural variant

938

1

L → P. Ref.7
Corresponds to variant rs6966329 [ dbSNP | Ensembl ].

VAR_060193

Experimental info

Sequence conflict

700

1

T → I in CAB66665. Ref.8

Secondary structure

1

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1075

Helix Strand Turn

Details...

Helix

52 – 60

9

Beta strand

62 – 68

7

Beta strand

79 – 84

6

Helix

89 – 99

11

Helix

104 – 109

6

Beta strand

110 – 117

8

Beta strand

130 – 133

4

Helix

140 – 146

7

Beta strand

154 – 161

8

Helix

162 – 188

27

Beta strand

974 – 980

7

Beta strand

988 – 992

5

Turn

993 – 995

3

Beta strand

1001 – 1008

8

Helix

1013 – 1017

5

Beta strand

1025 – 1031

7

Helix

1039 – 1047

9

Beta strand

1051 – 1058

8

Helix

1062 – 1068

7

Sequences

	Sequence		Length	Mass (Da)
	Isoform 4 [UniParc]. Last modified January 11, 2011. Version 5. Checksum: A071219E8FD10131	FASTA	1,075	117,455
	10 20 30 40 50 60 MFYGTHFIMS PPTKSKLKRQ SQLLSSMLSR TLSYKYRDLD STFSSLGASD DPAELSTQLS 70 80 90 100 110 120 APGVLKVFGD SVCTGTHYKS VLATGTSSAR ELVKEALERY ALDPRQAGQY VLCDVVGQAG 130 140 150 160 170 180 DAGQRWQARC FRVFGDSEKP LLIQELWKPR EGLSRRFELR KRSDVEELAA KEVDTITAGI 190 200 210 220 230 240 NAQARRLQRS RAKGTPTPAL GDARSSPPPR LRRTVSETSL SPVNALPAAA QGPEEPGPDA 250 260 270 280 290 300 MRYSLYQSPH LLLLQGYSQQ HDSLVYVLNR DRHTVGQRTP SSKPSISLSA PDILPLHCTI 310 320 330 340 350 360 RRQPLPDSGQ AAGRLVLEPI PGAHISVNFS EVGHRTVVLH HGDLLSLGLY YLLLFKDPAQ 370 380 390 400 410 420 AQPLPARALA RLRAVPQSCR LCGAALGARG AASPTQAALP RRQQLLLEFE PHLEDTLLQR 430 440 450 460 470 480 IMTLIEPGGD DHKLTPAFLL CLCIQHSATH FQPGTFGQLL LKIARLIRET VWEKTKELAE 490 500 510 520 530 540 KQAQLQEPIS LASCAMADLV PDLQPILFWM SNSIELLYFI QQKCPLYMQS MEEQLDITGS 550 560 570 580 590 600 KESLFSCTLT ASEEAMAVLE EVVLYAFQQC VYYVSKSLYI CLPALLECPP FQTERRESWS 610 620 630 640 650 660 SAPELPEELR RVVSVYQAAL DLLRQLQVHP EVASQMLAYL FFFSGTLLLN QLLDRGPSLS 670 680 690 700 710 720 CFHWPRGVQA CARLQQLLEW MRSAGFGAAG EHFFQKLSCT LNLLATPRAQ LIQMSWTALR 730 740 750 760 770 780 AAFPALSPAQ LHRLLTHYQL ASAMGPMSTW EPGAQDSPEA FRSEDVLESY ENPPPIVLPS 790 800 810 820 830 840 DGFQVDLEAN CLDDSIYQHL LYVRHFLWGL RSRASPGSPG RPGSGASQPV CPEGMHHVVL 850 860 870 880 890 900 DGHLEAPSCP LAPRDPGPAA REVAPERTLP LRGAPWAQAP PGRQPSRGGS QAGPPHTDSS 910 920 930 940 950 960 CLLTPPSTPL GPEPGDPDWP ESGGPCGKAL PERQRNGLSG LRGAAPEGDS AALAEESPPA 970 980 990 1000 1010 1020 PSSRSSSTED FCYVFTVELE RGPSGLGMGL IDGMHTHLGA PGLYIQTLLP GSPAAADGRL 1030 1040 1050 1060 1070 SLGDRILEVN GSSLLGLGYL RAVDLIRHGG KKMRFLVAKS DVETAKKIHF RTPPL
	Isoform 2 [UniParc]. Checksum: DA26C51AF63798BF	FASTA	580	63,118
	10 20 30 40 50 60 MADLVPDLQP ILFWMSNSIE LLYFIQQKCP LYMQSMEEQL DITGSKESLF SCTLTASEEA 70 80 90 100 110 120 MAVLEEVVLY AFQQCVYYVS KSLYICLPAL LECPPFQTER RESWSSAPEL PEELRRVVSV 130 140 150 160 170 180 YQAALDLLRQ LQVHPEVASQ MLAYLFFFSG TLLLNQLLDR GPSLSCFHWP RGVQACARLQ 190 200 210 220 230 240 QLLEWMRSAG FGAAGEHFFQ KLSCTLNLLA TPRAQLIQMS WTALRAAFPA LSPAQLHRLL 250 260 270 280 290 300 THYQLASAMG PMSTWEPGAQ DSPEAFRSED VLESYENPPP IVLPSDGFQV DLEANCLDDS 310 320 330 340 350 360 IYQHLLYVRH FLWGLRSRAS PGSPGRPGSG ASQPVCPEGM HHVVLDGHLE APSCPLAPRD 370 380 390 400 410 420 PGPAAREVAP ERTLPLRGAP WAQAPPGRQP SRGGSQAGPP HTDSSCLLTP PSTPLGPEPG 430 440 450 460 470 480 DPDWPESGGP CGKALPERQR NGLSGLRGAA PEGDSAALAE ESPPAPSSRS SSTEDFCYVF 490 500 510 520 530 540 TVELERGPSG LGMGLIDGMH THLGAPGLYI QTLLPGSPAA ADGRLSLGDR ILEVNGSSLL 550 560 570 580 GLGYLRAVDL IRHGGKKMRF LVAKSDVETA KKIHFRTPPL
	Isoform 3 [UniParc]. Checksum: FBD298E4B59C5BAB	FASTA	371	38,824
	10 20 30 40 50 60 MSPRVGPVTV ARIPASCVHR AGDSGLNLLA PGFPHRWAGR PGEGGSFSCG HYGHPLSPAE 70 80 90 100 110 120 DVLESYENPP PIVLPSDGFQ VDLEANCLDD SIYQHLLYVR HFLWGLRSRA SPGSPGRPGS 130 140 150 160 170 180 GASQPVCPEG MHHVVLDGHL EAPSCPLAPR DPGPAAREVA PERTLPLRGA PWAQAPPGRQ 190 200 210 220 230 240 PSRGGSQAGP PHTDSSCLLT PPSTPLGPEP GDPDWPESGG PCGKALPERQ RNGLSGLRGA 250 260 270 280 290 300 APEGDSAALA EESPPAPSSR SSSTEDFCYV FTVELERGPS GLGMGLIDGM HTHLGAPGLY 310 320 330 340 350 360 IQTLLPGSPA AADGRLSLGD RILEVNGSSL LGLGYLRAVD LIRHGGKKMR FLVAKSDVET 370 AKKIHFRTPP L
	Isoform 1 [UniParc]. Checksum: BE16FDC66C40E658	FASTA	1,073	116,757
	10 20 30 40 50 60 MFYGTHFIMS PPTKSKLKRQ SQLLSSMLSR TLSYKYRDLD STFSSLGASD DPAELSTQLS 70 80 90 100 110 120 APGVLKVFGD SVCTGTHYKS VLATGTSSAR ELVKEALERY ALDPRQAGQY VLCDVVGQAG 130 140 150 160 170 180 DAGQRWQARC FRVFGDSEKP LLIQELWKPR EGLSRRFELR KRSDVEELAA KEVDTITAGI 190 200 210 220 230 240 NAQARRLQRS RAKGTPTPAL GDARSSPPPR LRRTVSETSL SPVNALPAAA QGPEEPGPDA 250 260 270 280 290 300 MRYSLYQSPH LLLLQGYSQQ HPGVCAQPGP AHGGPADPSS KPSISLSAPD ILPLHCTIRR 310 320 330 340 350 360 QPLPDSGQAA GRLVLEPIPG AHISVNFSEV GHRTVVLHHG DLLSLGLYYL LLFKDPAQAQ 370 380 390 400 410 420 PLPARALARL RAVPQSCRLC GAALGARGAA SPTQAALPRR QQLLLEFEPH LEDTLLQRIM 430 440 450 460 470 480 TLIEPGGDDH KLTPAFLLCL CIQHSATHFQ PGTFGQLLLK IARLIRETVW EKTKELAEKQ 490 500 510 520 530 540 AQLQEPISLA SCAMADLVPD LQPILFWMSN SIELLYFIQQ KCPLYMQSME EQLDITGSKE 550 560 570 580 590 600 SLFSCTLTAS EEAMAVLEEV VLYAFQQCVY YVSKSLYICL PALLECPPFQ TERRESWSSA 610 620 630 640 650 660 PELPEELRRV VSVYQAALDL LRQLQVHPEV ASQMLAYLFF FSGTLLLNQL LDRGPSLSCF 670 680 690 700 710 720 HWPRGVQACA RLQQLLEWMR SAGFGAAGEH FFQKLSCTLN LLATPRAQLI QMSWTALRAA 730 740 750 760 770 780 FPALSPAQLH RLLTHYQLAS AMGPMSTWEP GAQDSPEAFR SEDVLESYEN PPPIVLPSDG 790 800 810 820 830 840 FQVDLEANCL DDSIYQHLLY VRHFLWGLRS RASPGSPGRP GSGASQPVCP EGMHHVVLDG 850 860 870 880 890 900 HLEAPSCPLA PRDPGPAARE VAPERTLPLR GAPWAQAPPG RQPSRGGSQA GPPHTDSSCL 910 920 930 940 950 960 LTPPSTPLGP EPGDPDWPES GGPCGKALPE RQRNGLSGLR GAAPEGDSAA LAEESPPAPS 970 980 990 1000 1010 1020 SRSSSTEDFC YVFTVELERG PSGLGMGLID GMHTHLGAPG LYIQTLLPGS PAAADGRLSL 1030 1040 1050 1060 1070 GDRILEVNGS SLLGLGYLRA VDLIRHGGKK MRFLVAKSDV ETAKKIHFRT PPL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Nakayama M., Nakajima D., Kikuno R., Ohara O. DNA Res. 8:85-95(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS ASN-239; ASP-412 AND GLY-886. Tissue: Brain.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 283-1075 (ISOFORM 1), VARIANTS ASP-412 AND GLY-886. Tissue: Embryo and Teratocarcinoma.
[3]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4), VARIANTS ASN-239; ASP-412 AND GLY-886. Tissue: Testis.
[4]	"The DNA sequence of human chromosome 7." Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L. , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K. Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"Human chromosome 7: DNA sequence and biology." Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S. , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C. Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT GLY-886.
[6]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT GLY-886.
[7]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 3 AND 4), VARIANTS GLY-886 AND PRO-938. Tissue: Heart, Lung and Skin.
[8]	"Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs." Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S., Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H., Lauber J., Duesterhoeft A., Beyer A., Koehrer K., Strack N., Mewes H.-W., Ottenwaelder B., Obermaier B. , Tampe J., Heubner D., Wambutt R., Korn B., Klein M., Poustka A. Genome Res. 11:422-435(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 533-1075, VARIANT GLY-886. Tissue: Testis.
[9]	"A Rap GTPase interactor, RADIL, mediates migration of neural crest precursors." Smolen G.A., Schott B.J., Stewart R.A., Diederichs S., Muir B., Provencher H.L., Look A.T., Sgroi D.C., Peterson R.T., Haber D.A. Genes Dev. 21:2131-2136(2007) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, INTERACTION WITH RAP1A.
[10]	"Solution structure of RSGI RUH-007, a PDZ domain." RIKEN structural genomics initiative (RSGI) Submitted (MAR-2004) to the PDB data bank Cited for: STRUCTURE BY NMR OF 973-1069.
[11]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT [LARGE SCALE ANALYSIS] ASN-239, MASS SPECTROMETRY. Tissue: Leukemic T-cell.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AB058752 mRNA. Translation: BAB47478.1. Different initiation.
AK000997 mRNA. Translation: BAA91459.1.
AK001186 mRNA. Translation: BAA91543.1. Different initiation.
EF560723 mRNA. Translation: ABQ59033.1.
AC092610 Genomic DNA. Translation: AAS07559.1. Sequence problems.
CH236953 Genomic DNA. Translation: EAL23966.1.
CH471144 Genomic DNA. Translation: EAW87301.1.
BC004919 mRNA. Translation: AAH04919.2.
BC117317 mRNA. Translation: AAI17318.1.
BC126311 mRNA. Translation: AAI26312.1.
BC143526 mRNA. Translation: AAI43527.1.
AL136731 mRNA. Translation: CAB66665.2.

IPI

IPI00437989.
IPI00746097.
IPI00903081.
IPI01012458.

RefSeq

NP_060529.4. NM_018059.4.

UniGene

Hs.667336.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1UM1	NMR	-	A	973-1069	[»]
3EC8	X-ray	2.60	A	51-193	[»]

ProteinModelPortal

Q96JH8.

SMR

Q96JH8. Positions 49-189, 247-361, 973-1069.

ModBase

Search...

Protein-protein interaction databases

IntAct

Q96JH8. 4 interactions.

MINT

MINT-1391797.

PTM databases

PhosphoSite

Q96JH8.

Polymorphism databases

DMDM

215274236.

Proteomic databases

PaxDb

Q96JH8.

PRIDE

Q96JH8.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000399583; ENSP00000382492; ENSG00000157927.

GeneID

55698.

KEGG

hsa:55698.

UCSC

uc003snh.1. human.
uc003sni.1. human.

Organism-specific databases

CTD

55698.

GeneCards

GC07M004836.

H-InvDB

HIX0006446.

HGNC

HGNC:22226. RADIL.

HPA

HPA051776.

MIM

611491. gene.

neXtProt

NX_Q96JH8.

PharmGKB

PA164725261.

HUGE

Search...

GenAtlas

Search...

Phylogenomic databases

eggNOG

NOG309163.

HOVERGEN

HBG079536.

OMA

GGDDHKL.

OrthoDB

EOG4RJG0X.

Gene expression databases

ArrayExpress

Q96JH8.

Bgee

Q96JH8.

Genevestigator

Q96JH8.

GermOnline

ENSG00000157927. Homo sapiens.

Family and domain databases

Gene3D

2.60.200.20. 1 hit.

InterPro

IPR018444. Dil_domain.
IPR002710. Dilute.
IPR000253. FHA_dom.
IPR001478. PDZ.
IPR000159. Ras-assoc.
IPR008984. SMAD_FHA_domain.
[Graphical view]

Pfam

PF01843. DIL. 1 hit.
PF00595. PDZ. 1 hit.
PF00788. RA. 1 hit.
[Graphical view]

SMART

SM00228. PDZ. 1 hit.
SM00314. RA. 1 hit.
[Graphical view]

SUPFAM

SSF50156. PDZ. 1 hit.
SSF49879. SMAD_FHA. 1 hit.

PROSITE

PS51126. DILUTE. 1 hit.
PS50006. FHA_DOMAIN. False negative.
PS50106. PDZ. 1 hit.
PS50200. RA. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

ChiTaRS

RADIL. human.

EvolutionaryTrace

Q96JH8.

GenomeRNAi

55698.

NextBio

60531.

SOURCE

Search...

Entry information

Entry name

RADIL_HUMAN

Accession

Primary (citable) accession number: Q96JH8
Secondary accession number(s): A4D1Z5 , A5YM49, B7ZL20, Q0VFZ9, Q75LH3, Q9BSP5, Q9H0M6, Q9NW43, Q9NWC4

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 8, 2005
Last sequence update:	January 11, 2011
Last modified:	May 1, 2013
This is version 94 of the entry and version 5 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.