Q96JG8 (MAGD4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Melanoma-associated antigen D4

Alternative name(s):
MAGE-D4 antigen
MAGE-E1 antigen

Gene names

Name:	MAGED4
Synonyms:	KIAA1859, MAGED4A, MAGEE1
AND
Name:	MAGED4B

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	741 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. Ref.13
Subunit structure	Interacts with TRIM27. Ref.13
Tissue specificity	Expressed only in brain and ovary among normal tissues. Isoform 1 and isoform 2 are specifically expressed in glioma cells among cancer cells. Detected in some renal cell carcinoma samples. Ref.1 Ref.12
Sequence similarities	Contains 1 MAGE domain.
Sequence caution	The sequence AAH01207.1 differs from that shown. Reason: Erroneous initiation. The sequence AAL50032.1 differs from that shown. Reason: Frameshift at positions 186 and 219. The sequence BAB47488.2 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Ubl conjugation pathway
Coding sequence diversity	Alternative splicing
Molecular function	Tumor antigen
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q96JG8-1)

Also known as: MAGE-E1a;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q96JG8-2)

Also known as: MAGE-E1b;

The sequence of this isoform differs from the canonical sequence as follows:
     740-741: Missing.

Isoform 3 (identifier: Q96JG8-3)

Also known as: MAGE-E1c;

The sequence of this isoform differs from the canonical sequence as follows:
     349-414: SKHLDDEYES...LPPRNVTLLQ → VRSPCPLPPP...LVHVSPTQVC
     415-741: Missing.

Isoform 4 (identifier: Q96JG8-4)

The sequence of this isoform differs from the canonical sequence as follows:
     557-557: K → KNPELREETPLSMAPSW

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 741	741	Melanoma-associated antigen D4		PRO_0000156728
Regions
	Domain	413 – 611	199	MAGE
	Compositional bias	97 – 339	243	Ala-rich
Natural variations
	Alternative sequence	349 – 414	66	SKHLD…VTLLQ → VRSPCPLPPPHPLAPVLSFS SLSCSSPPSPLPLLPLFSSF PSFSPHLPSPPLLSSQLVHV SPTQVC in isoform 3.		VSP_009288
	Alternative sequence	415 – 741	327	Missing in isoform 3.		VSP_009289
	Alternative sequence	557	1	K → KNPELREETPLSMAPSW in isoform 4.		VSP_035013
	Alternative sequence	740 – 741	2	Missing in isoform 2.		VSP_009287
Experimental info
	Sequence conflict	314	1	A → V in BAF82147. Ref.6
	Sequence conflict	635	1	Q → R Ref.10

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (MAGE-E1a) [UniParc]. Last modified January 16, 2004. Version 3. Checksum: 56B073324C12A8EC	FASTA	741	81,378
	10 20 30 40 50 60 MAEGSFSVQS ESYSVEDMDE GSDEVGEEEM VEGNDYEEFG AFGGYGTLTS FDIHILRAFG 70 80 90 100 110 120 SLGPGLRILS NEPWELENPV LAQTLVEALQ LDPETLANET AARAANVARA AASNRAARAA 130 140 150 160 170 180 AAAARTAFSQ VVASHRVATP QVSGEDTQPT TYAAEAQGPT PEPPLASPQT SQMLVTSKMA 190 200 210 220 230 240 APEAPATSAQ SQTGSPAQEA ATEGPSSACA FSQAPCAREV DANRPSTAFL GQNDVFDFTQ 250 260 270 280 290 300 PAGVSGMAFP RPKRPAPAQE AATEGPSAAS GVPQTGPGRE VAATRPKTTK SGKALAKTRW 310 320 330 340 350 360 VEPQNVVAAA AAKAKMATSI PEPEGAAAAT AQHSAEPWAR MGGKRTKKSK HLDDEYESSE 370 380 390 400 410 420 EERETPAVPP TWRASQPSLT VRAQLAPRPP MAPRSQIPSR HVLCLPPRNV TLLQERANKL 430 440 450 460 470 480 VKYLMIKDYK KIPIKRADML KDVIREYDEH FPEIIERATY TLEKKFGIHL KEIDKEEHLY 490 500 510 520 530 540 ILVCTRDSSA RLLGKTKDTP RLSLLLVILG VIFMNGNRAS EAVLWEALRK MGLRPGVRHP 550 560 570 580 590 600 FLGDLRKLIT DDFVKQKYLE YKKIPNSNPP EYEFLWGLRA RHETSKMRVL RFIAQNQNRD 610 620 630 640 650 660 PREWKAHFLE AVDDAFKTMD VDMAEEHARA QMRAQMNIGD EALIGRWSWD DIQVELLTWD 670 680 690 700 710 720 EDGDFGDAWA RIPFAFWARY HQYILNSNRA NRRATWRAGV SSGTNGGAST SVLDGPSTSS 730 740 TIRTRNAARA GASFFSWIQH R
	Isoform 2 (MAGE-E1b) [UniParc]. Checksum: A3324C12A8EC3BAB	FASTA	739	81,084
	10 20 30 40 50 60 MAEGSFSVQS ESYSVEDMDE GSDEVGEEEM VEGNDYEEFG AFGGYGTLTS FDIHILRAFG 70 80 90 100 110 120 SLGPGLRILS NEPWELENPV LAQTLVEALQ LDPETLANET AARAANVARA AASNRAARAA 130 140 150 160 170 180 AAAARTAFSQ VVASHRVATP QVSGEDTQPT TYAAEAQGPT PEPPLASPQT SQMLVTSKMA 190 200 210 220 230 240 APEAPATSAQ SQTGSPAQEA ATEGPSSACA FSQAPCAREV DANRPSTAFL GQNDVFDFTQ 250 260 270 280 290 300 PAGVSGMAFP RPKRPAPAQE AATEGPSAAS GVPQTGPGRE VAATRPKTTK SGKALAKTRW 310 320 330 340 350 360 VEPQNVVAAA AAKAKMATSI PEPEGAAAAT AQHSAEPWAR MGGKRTKKSK HLDDEYESSE 370 380 390 400 410 420 EERETPAVPP TWRASQPSLT VRAQLAPRPP MAPRSQIPSR HVLCLPPRNV TLLQERANKL 430 440 450 460 470 480 VKYLMIKDYK KIPIKRADML KDVIREYDEH FPEIIERATY TLEKKFGIHL KEIDKEEHLY 490 500 510 520 530 540 ILVCTRDSSA RLLGKTKDTP RLSLLLVILG VIFMNGNRAS EAVLWEALRK MGLRPGVRHP 550 560 570 580 590 600 FLGDLRKLIT DDFVKQKYLE YKKIPNSNPP EYEFLWGLRA RHETSKMRVL RFIAQNQNRD 610 620 630 640 650 660 PREWKAHFLE AVDDAFKTMD VDMAEEHARA QMRAQMNIGD EALIGRWSWD DIQVELLTWD 670 680 690 700 710 720 EDGDFGDAWA RIPFAFWARY HQYILNSNRA NRRATWRAGV SSGTNGGAST SVLDGPSTSS 730 TIRTRNAARA GASFFSWIQ
	Isoform 3 (MAGE-E1c) [UniParc]. Checksum: 9E9B0351E0B580D8	FASTA	414	42,774
	10 20 30 40 50 60 MAEGSFSVQS ESYSVEDMDE GSDEVGEEEM VEGNDYEEFG AFGGYGTLTS FDIHILRAFG 70 80 90 100 110 120 SLGPGLRILS NEPWELENPV LAQTLVEALQ LDPETLANET AARAANVARA AASNRAARAA 130 140 150 160 170 180 AAAARTAFSQ VVASHRVATP QVSGEDTQPT TYAAEAQGPT PEPPLASPQT SQMLVTSKMA 190 200 210 220 230 240 APEAPATSAQ SQTGSPAQEA ATEGPSSACA FSQAPCAREV DANRPSTAFL GQNDVFDFTQ 250 260 270 280 290 300 PAGVSGMAFP RPKRPAPAQE AATEGPSAAS GVPQTGPGRE VAATRPKTTK SGKALAKTRW 310 320 330 340 350 360 VEPQNVVAAA AAKAKMATSI PEPEGAAAAT AQHSAEPWAR MGGKRTKKVR SPCPLPPPHP 370 380 390 400 410 LAPVLSFSSL SCSSPPSPLP LLPLFSSFPS FSPHLPSPPL LSSQLVHVSP TQVC
	Isoform 4 [UniParc]. Checksum: C52971EDE25D26F0	FASTA	757	83,217
	10 20 30 40 50 60 MAEGSFSVQS ESYSVEDMDE GSDEVGEEEM VEGNDYEEFG AFGGYGTLTS FDIHILRAFG 70 80 90 100 110 120 SLGPGLRILS NEPWELENPV LAQTLVEALQ LDPETLANET AARAANVARA AASNRAARAA 130 140 150 160 170 180 AAAARTAFSQ VVASHRVATP QVSGEDTQPT TYAAEAQGPT PEPPLASPQT SQMLVTSKMA 190 200 210 220 230 240 APEAPATSAQ SQTGSPAQEA ATEGPSSACA FSQAPCAREV DANRPSTAFL GQNDVFDFTQ 250 260 270 280 290 300 PAGVSGMAFP RPKRPAPAQE AATEGPSAAS GVPQTGPGRE VAATRPKTTK SGKALAKTRW 310 320 330 340 350 360 VEPQNVVAAA AAKAKMATSI PEPEGAAAAT AQHSAEPWAR MGGKRTKKSK HLDDEYESSE 370 380 390 400 410 420 EERETPAVPP TWRASQPSLT VRAQLAPRPP MAPRSQIPSR HVLCLPPRNV TLLQERANKL 430 440 450 460 470 480 VKYLMIKDYK KIPIKRADML KDVIREYDEH FPEIIERATY TLEKKFGIHL KEIDKEEHLY 490 500 510 520 530 540 ILVCTRDSSA RLLGKTKDTP RLSLLLVILG VIFMNGNRAS EAVLWEALRK MGLRPGVRHP 550 560 570 580 590 600 FLGDLRKLIT DDFVKQKNPE LREETPLSMA PSWYLEYKKI PNSNPPEYEF LWGLRARHET 610 620 630 640 650 660 SKMRVLRFIA QNQNRDPREW KAHFLEAVDD AFKTMDVDMA EEHARAQMRA QMNIGDEALI 670 680 690 700 710 720 GRWSWDDIQV ELLTWDEDGD FGDAWARIPF AFWARYHQYI LNSNRANRRA TWRAGVSSGT 730 740 750 NGGASTSVLD GPSTSSTIRT RNAARAGASF FSWIQHR

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"MAGE-E1, a new member of the melanoma-associated antigen gene family and its expression in human glioma." Sasaki M., Nakahira K., Kawano Y., Katakura H., Yoshimine T., Shimizu K., Kim S.U., Ikenaka K. Cancer Res. 61:4809-4814(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3), TISSUE SPECIFICITY.
[2]	"Structural characterization and chromosomal localization of the MAGE-E1 gene." Kawano Y., Sasaki M., Nakahira K., Yoshimine T., Shimizu K., Wada H., Ikenaka K. Gene 277:129-137(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS 1; 2 AND 3).
[3]	"Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs." Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S., Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H., Lauber J., Duesterhoeft A., Beyer A., Koehrer K., Strack N., Mewes H.-W., Ottenwaelder B., Obermaier B. , Tampe J., Heubner D., Wambutt R., Korn B., Klein M., Poustka A. Genome Res. 11:422-435(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Amygdala.
[4]	"Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Nakayama M., Nakajima D., Kikuno R., Ohara O. DNA Res. 8:85-95(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Brain.
[5]	"Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones." Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T. DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract] Cited for: SEQUENCE REVISION.
[6]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[7]	"The DNA sequence of the human X chromosome." Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C. , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R. Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[8]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[9]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 4). Tissue: Brain, Eye and PNS.
[10]	"Identification of a novel member of human Mage-D subfamily genes." Zhang C. Submitted (DEC-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 60-741.
[11]	"Identification of new genes of the MAGE family." Lucas S., Boon T. Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 497-627. Tissue: Testis.
[12]	"MAGED4-expression in renal cell carcinoma and identification of an HLA-A*25-restricted MHC class I ligand from solid tumor tissue." Kraemer B.F., Schoor O., Krueger T., Reichle C., Mueller M., Weinschenk T., Hennenlotter J., Stenzl A., Rammensee H.-G., Stevanovic S. Cancer Biol. Ther. 4:943-948(2005) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY.
[13]	"MAGE-RING protein complexes comprise a family of E3 ubiquitin ligases." Doyle J.M., Gao J., Wang J., Yang M., Potts P.R. Mol. Cell 39:963-974(2010) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, INTERACTION WITH TRIM27.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB040527 mRNA. Translation: BAB33378.1. AB040528 mRNA. Translation: BAB33379.1. AB040529 mRNA. Translation: BAB33380.1. AB056059 Genomic DNA. Translation: BAB61778.1. AB056059 Genomic DNA. Translation: BAB61779.1. AB056059 Genomic DNA. Translation: BAB61780.1. AL136582 mRNA. Translation: CAB66517.1. AB058762 mRNA. Translation: BAB47488.2. Different initiation. AK289458 mRNA. Translation: BAF82147.1. AL928717 Genomic DNA. Translation: CAI40426.1. BX537154 Genomic DNA. Translation: CAI41307.1. CH471230 Genomic DNA. Translation: EAW62885.1. BC001207 mRNA. Translation: AAH01207.1. Different initiation. BC063838 mRNA. Translation: AAH63838.1. BC081566 mRNA. Translation: AAH81566.1. AF329733 mRNA. Translation: AAL50032.1. Frameshift. AF320908 mRNA. Translation: AAG38604.1.
IPI	IPI00335512. IPI00387072. IPI00396651. IPI00902794.
RefSeq	NP_001092270.1. NM_001098800.2. NP_001229291.1. NM_001242362.1. NP_001258990.1. NM_001272061.1. NP_001258991.1. NM_001272062.1. NP_001258992.1. NM_001272063.1. NP_110428.2. NM_030801.3. NP_803879.1. NM_177535.2. NP_803881.1. NM_177537.2.
UniGene	Hs.522650. Hs.571729.
3D structure databases
ProteinModelPortal	Q96JG8.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q96JG8. 5 interactions.
PTM databases
PhosphoSite	Q96JG8.
Polymorphism databases
DMDM	41017391.
Proteomic databases
PaxDb	Q96JG8.
PRIDE	Q96JG8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000335504; ENSP00000335385; ENSG00000187243. ENST00000360134; ENSP00000353252; ENSG00000187243. ENST00000375626; ENSP00000364777; ENSG00000154545. ENST00000416960; ENSP00000399147; ENSG00000154545. ENST00000431659; ENSP00000395962; ENSG00000187243. ENST00000485287; ENSP00000421861; ENSG00000187243. ENST00000497164; ENSP00000423848; ENSG00000187243. ENST00000593675; ENSP00000473102; ENSG00000268682. ENST00000595965; ENSP00000470563; ENSG00000268682. ENST00000600173; ENSP00000472359; ENSG00000268682. ENST00000601229; ENSP00000470745; ENSG00000268682. ENST00000601264; ENSP00000469084; ENSG00000268682.
GeneID	728239. 81557.
KEGG	hsa:728239. hsa:81557.
UCSC	uc004dpr.4. human. uc004dps.4. human.
Organism-specific databases
CTD	728239. 81557.
GeneCards	GC0XM051822. GC0XP051927.
HGNC	HGNC:23793. MAGED4. HGNC:22880. MAGED4B.
HPA	HPA003554.
MIM	300702. gene. 300765. gene.
neXtProt	NX_Q96JG8.
PharmGKB	PA145148472.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG276522.
HOVERGEN	HBG003714.
InParanoid	Q96JG8.
OMA	ARYHQYI.
PhylomeDB	Q96JG8.
Gene expression databases
ArrayExpress	Q96JG8.
Bgee	Q96JG8.
CleanEx	HS_MAGED4. HS_MAGEE1.
Genevestigator	Q96JG8.
GermOnline	ENSG00000154545. Homo sapiens. ENSG00000187243. Homo sapiens.
Family and domain databases
InterPro	IPR002190. MAGE. [Graphical view]
PANTHER	PTHR11736. PTHR11736. 1 hit.
Pfam	PF01454. MAGE. 1 hit. [Graphical view]
PROSITE	PS50838. MAGE. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	MAGED4B. human.
NextBio	126567.
SOURCE	Search...

Entry information

Entry name

MAGD4_HUMAN

Accession

Primary (citable) accession number: Q96JG8
Secondary accession number(s): A8K093 , Q5HYN6, Q8WXW4, Q9BQ84, Q9BVH1, Q9BYH3, Q9BYH4, Q9H217

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 16, 2004
Last sequence update:	January 16, 2004
Last modified:	May 1, 2013
This is version 93 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.