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Q96JG8

- MAGD4_HUMAN

UniProt

Q96JG8 - MAGD4_HUMAN

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Protein
Melanoma-associated antigen D4
Gene
MAGED4, KIAA1859, MAGED4A, MAGEE1
MAGED4B
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex.1 Publication

Keywords - Molecular functioni

Tumor antigen

Keywords - Biological processi

Ubl conjugation pathway

Names & Taxonomyi

Organism-specific databases

Protein namesi
Recommended name:
Melanoma-associated antigen D4
Alternative name(s):
MAGE-D4 antigen
MAGE-E1 antigen
Gene namesi
Name:MAGED4
Synonyms:KIAA1859, MAGED4A, MAGEE1
AND
Name:MAGED4B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome X
HGNCiHGNC:23793. MAGED4.
HGNC:22880. MAGED4B.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA145148472.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 741741Melanoma-associated antigen D4
PRO_0000156728Add
BLAST

Proteomic databases

MaxQBiQ96JG8.
PaxDbiQ96JG8.
PRIDEiQ96JG8.

PTM databases

PhosphoSiteiQ96JG8.

Expressioni

Tissue specificityi

Expressed only in brain and ovary among normal tissues. Isoform 1 and isoform 2 are specifically expressed in glioma cells among cancer cells. Detected in some renal cell carcinoma samples.2 Publications

Gene expression databases

BgeeiQ96JG8.
CleanExiHS_MAGED4.
HS_MAGEE1.
GenevestigatoriQ96JG8.

Organism-specific databases

HPAiHPA003554.

Interactioni

Subunit structurei

Interacts with TRIM27.1 Publication

Protein-protein interaction databases

BioGridi123521. 8 interactions.
608671. 4 interactions.
IntActiQ96JG8. 6 interactions.
MINTiMINT-8247559.

Structurei

3D structure databases

ProteinModelPortaliQ96JG8.
SMRiQ96JG8. Positions 407-614.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini413 – 611199MAGE
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi97 – 339243Ala-rich
Add
BLAST

Sequence similaritiesi

Contains 1 MAGE domain.

Phylogenomic databases

eggNOGiNOG276522.
HOVERGENiHBG003714.
InParanoidiQ96JG8.
OMAiCAFSQAP.
OrthoDBiEOG75F4GM.
PhylomeDBiQ96JG8.
TreeFamiTF352132.

Family and domain databases

InterProiIPR002190. MAGE.
[Graphical view]
PANTHERiPTHR11736. PTHR11736. 1 hit.
PfamiPF01454. MAGE. 1 hit.
[Graphical view]
PROSITEiPS50838. MAGE. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q96JG8-1) [UniParc]FASTAAdd to Basket

Also known as: MAGE-E1a

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MAEGSFSVQS ESYSVEDMDE GSDEVGEEEM VEGNDYEEFG AFGGYGTLTS    50
FDIHILRAFG SLGPGLRILS NEPWELENPV LAQTLVEALQ LDPETLANET 100
AARAANVARA AASNRAARAA AAAARTAFSQ VVASHRVATP QVSGEDTQPT 150
TYAAEAQGPT PEPPLASPQT SQMLVTSKMA APEAPATSAQ SQTGSPAQEA 200
ATEGPSSACA FSQAPCAREV DANRPSTAFL GQNDVFDFTQ PAGVSGMAFP 250
RPKRPAPAQE AATEGPSAAS GVPQTGPGRE VAATRPKTTK SGKALAKTRW 300
VEPQNVVAAA AAKAKMATSI PEPEGAAAAT AQHSAEPWAR MGGKRTKKSK 350
HLDDEYESSE EERETPAVPP TWRASQPSLT VRAQLAPRPP MAPRSQIPSR 400
HVLCLPPRNV TLLQERANKL VKYLMIKDYK KIPIKRADML KDVIREYDEH 450
FPEIIERATY TLEKKFGIHL KEIDKEEHLY ILVCTRDSSA RLLGKTKDTP 500
RLSLLLVILG VIFMNGNRAS EAVLWEALRK MGLRPGVRHP FLGDLRKLIT 550
DDFVKQKYLE YKKIPNSNPP EYEFLWGLRA RHETSKMRVL RFIAQNQNRD 600
PREWKAHFLE AVDDAFKTMD VDMAEEHARA QMRAQMNIGD EALIGRWSWD 650
DIQVELLTWD EDGDFGDAWA RIPFAFWARY HQYILNSNRA NRRATWRAGV 700
SSGTNGGAST SVLDGPSTSS TIRTRNAARA GASFFSWIQH R 741
Length:741
Mass (Da):81,378
Last modified:January 16, 2004 - v3
Checksum:i56B073324C12A8EC
GO
Isoform 2 (identifier: Q96JG8-2) [UniParc]FASTAAdd to Basket

Also known as: MAGE-E1b

The sequence of this isoform differs from the canonical sequence as follows:
     740-741: Missing.

Show »
Length:739
Mass (Da):81,084
Checksum:iA3324C12A8EC3BAB
GO
Isoform 3 (identifier: Q96JG8-3) [UniParc]FASTAAdd to Basket

Also known as: MAGE-E1c

The sequence of this isoform differs from the canonical sequence as follows:
     349-414: SKHLDDEYES...LPPRNVTLLQ → VRSPCPLPPP...LVHVSPTQVC
     415-741: Missing.

Show »
Length:414
Mass (Da):42,774
Checksum:i9E9B0351E0B580D8
GO
Isoform 4 (identifier: Q96JG8-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     557-557: K → KNPELREETPLSMAPSW

Note: No experimental confirmation available.

Show »
Length:757
Mass (Da):83,217
Checksum:iC52971EDE25D26F0
GO

Sequence cautioni

The sequence AAL50032.1 differs from that shown. Reason: Frameshift at positions 186 and 219.
The sequence AAH01207.1 differs from that shown. Reason: Erroneous initiation.
The sequence BAB47488.2 differs from that shown. Reason: Erroneous initiation.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei349 – 41466SKHLD…VTLLQ → VRSPCPLPPPHPLAPVLSFS SLSCSSPPSPLPLLPLFSSF PSFSPHLPSPPLLSSQLVHV SPTQVC in isoform 3.
VSP_009288Add
BLAST
Alternative sequencei415 – 741327Missing in isoform 3.
VSP_009289Add
BLAST
Alternative sequencei557 – 5571K → KNPELREETPLSMAPSW in isoform 4.
VSP_035013
Alternative sequencei740 – 7412Missing in isoform 2.
VSP_009287

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti314 – 3141A → V in BAF82147. 1 Publication
Sequence conflicti635 – 6351Q → R1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB040527 mRNA. Translation: BAB33378.1.
AB040528 mRNA. Translation: BAB33379.1.
AB040529 mRNA. Translation: BAB33380.1.
AB056059 Genomic DNA. Translation: BAB61778.1.
AB056059 Genomic DNA. Translation: BAB61779.1.
AB056059 Genomic DNA. Translation: BAB61780.1.
AL136582 mRNA. Translation: CAB66517.1.
AB058762 mRNA. Translation: BAB47488.2. Different initiation.
AK289458 mRNA. Translation: BAF82147.1.
AL928717 Genomic DNA. Translation: CAI40426.1.
BX537154 Genomic DNA. Translation: CAI41307.1.
CH471230 Genomic DNA. Translation: EAW62885.1.
BC001207 mRNA. Translation: AAH01207.1. Different initiation.
BC063838 mRNA. Translation: AAH63838.1.
BC081566 mRNA. Translation: AAH81566.1.
AF329733 mRNA. Translation: AAL50032.1. Frameshift.
AF320908 mRNA. Translation: AAG38604.1.
CCDSiCCDS14338.1. [Q96JG8-1]
CCDS35281.1. [Q96JG8-2]
CCDS48116.1. [Q96JG8-2]
CCDS56602.1. [Q96JG8-4]
CCDS65261.1. [Q96JG8-4]
RefSeqiNP_001092270.1. NM_001098800.2. [Q96JG8-2]
NP_001229291.1. NM_001242362.1. [Q96JG8-4]
NP_001258990.1. NM_001272061.1. [Q96JG8-4]
NP_001258991.1. NM_001272062.1. [Q96JG8-1]
NP_001258992.1. NM_001272063.1. [Q96JG8-1]
NP_110428.2. NM_030801.3. [Q96JG8-1]
NP_803879.1. NM_177535.2. [Q96JG8-1]
NP_803881.1. NM_177537.2. [Q96JG8-2]
XP_006724670.1. XM_006724607.1. [Q96JG8-1]
XP_006724671.1. XM_006724608.1. [Q96JG8-1]
UniGeneiHs.522650.
Hs.571729.
Hs.733143.

Genome annotation databases

EnsembliENST00000335504; ENSP00000335385; ENSG00000187243. [Q96JG8-1]
ENST00000360134; ENSP00000353252; ENSG00000187243. [Q96JG8-2]
ENST00000375626; ENSP00000364777; ENSG00000154545. [Q96JG8-2]
ENST00000416960; ENSP00000399147; ENSG00000154545. [Q96JG8-4]
ENST00000431659; ENSP00000395962; ENSG00000187243. [Q96JG8-4]
ENST00000485287; ENSP00000421861; ENSG00000187243. [Q96JG8-4]
ENST00000497164; ENSP00000423848; ENSG00000187243. [Q96JG8-1]
ENST00000600173; ENSP00000472359; ENSG00000268682. [Q96JG8-4]
ENST00000606206; ENSP00000476029; ENSG00000268682. [Q96JG8-4]
ENST00000606606; ENSP00000476249; ENSG00000268682. [Q96JG8-2]
ENST00000606833; ENSP00000475674; ENSG00000268682. [Q96JG8-1]
ENST00000606940; ENSP00000475815; ENSG00000268682. [Q96JG8-1]
GeneIDi728239.
81557.
KEGGihsa:728239.
hsa:81557.
UCSCiuc004dpr.4. human. [Q96JG8-4]
uc004dps.4. human. [Q96JG8-1]

Polymorphism databases

DMDMi41017391.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB040527 mRNA. Translation: BAB33378.1 .
AB040528 mRNA. Translation: BAB33379.1 .
AB040529 mRNA. Translation: BAB33380.1 .
AB056059 Genomic DNA. Translation: BAB61778.1 .
AB056059 Genomic DNA. Translation: BAB61779.1 .
AB056059 Genomic DNA. Translation: BAB61780.1 .
AL136582 mRNA. Translation: CAB66517.1 .
AB058762 mRNA. Translation: BAB47488.2 . Different initiation.
AK289458 mRNA. Translation: BAF82147.1 .
AL928717 Genomic DNA. Translation: CAI40426.1 .
BX537154 Genomic DNA. Translation: CAI41307.1 .
CH471230 Genomic DNA. Translation: EAW62885.1 .
BC001207 mRNA. Translation: AAH01207.1 . Different initiation.
BC063838 mRNA. Translation: AAH63838.1 .
BC081566 mRNA. Translation: AAH81566.1 .
AF329733 mRNA. Translation: AAL50032.1 . Frameshift.
AF320908 mRNA. Translation: AAG38604.1 .
CCDSi CCDS14338.1. [Q96JG8-1 ]
CCDS35281.1. [Q96JG8-2 ]
CCDS48116.1. [Q96JG8-2 ]
CCDS56602.1. [Q96JG8-4 ]
CCDS65261.1. [Q96JG8-4 ]
RefSeqi NP_001092270.1. NM_001098800.2. [Q96JG8-2 ]
NP_001229291.1. NM_001242362.1. [Q96JG8-4 ]
NP_001258990.1. NM_001272061.1. [Q96JG8-4 ]
NP_001258991.1. NM_001272062.1. [Q96JG8-1 ]
NP_001258992.1. NM_001272063.1. [Q96JG8-1 ]
NP_110428.2. NM_030801.3. [Q96JG8-1 ]
NP_803879.1. NM_177535.2. [Q96JG8-1 ]
NP_803881.1. NM_177537.2. [Q96JG8-2 ]
XP_006724670.1. XM_006724607.1. [Q96JG8-1 ]
XP_006724671.1. XM_006724608.1. [Q96JG8-1 ]
UniGenei Hs.522650.
Hs.571729.
Hs.733143.

3D structure databases

ProteinModelPortali Q96JG8.
SMRi Q96JG8. Positions 407-614.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 123521. 8 interactions.
608671. 4 interactions.
IntActi Q96JG8. 6 interactions.
MINTi MINT-8247559.

PTM databases

PhosphoSitei Q96JG8.

Polymorphism databases

DMDMi 41017391.

Proteomic databases

MaxQBi Q96JG8.
PaxDbi Q96JG8.
PRIDEi Q96JG8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000335504 ; ENSP00000335385 ; ENSG00000187243 . [Q96JG8-1 ]
ENST00000360134 ; ENSP00000353252 ; ENSG00000187243 . [Q96JG8-2 ]
ENST00000375626 ; ENSP00000364777 ; ENSG00000154545 . [Q96JG8-2 ]
ENST00000416960 ; ENSP00000399147 ; ENSG00000154545 . [Q96JG8-4 ]
ENST00000431659 ; ENSP00000395962 ; ENSG00000187243 . [Q96JG8-4 ]
ENST00000485287 ; ENSP00000421861 ; ENSG00000187243 . [Q96JG8-4 ]
ENST00000497164 ; ENSP00000423848 ; ENSG00000187243 . [Q96JG8-1 ]
ENST00000600173 ; ENSP00000472359 ; ENSG00000268682 . [Q96JG8-4 ]
ENST00000606206 ; ENSP00000476029 ; ENSG00000268682 . [Q96JG8-4 ]
ENST00000606606 ; ENSP00000476249 ; ENSG00000268682 . [Q96JG8-2 ]
ENST00000606833 ; ENSP00000475674 ; ENSG00000268682 . [Q96JG8-1 ]
ENST00000606940 ; ENSP00000475815 ; ENSG00000268682 . [Q96JG8-1 ]
GeneIDi 728239.
81557.
KEGGi hsa:728239.
hsa:81557.
UCSCi uc004dpr.4. human. [Q96JG8-4 ]
uc004dps.4. human. [Q96JG8-1 ]

Organism-specific databases

CTDi 728239.
81557.
GeneCardsi GC0XM051822.
GC0XP051927.
HGNCi HGNC:23793. MAGED4.
HGNC:22880. MAGED4B.
HPAi HPA003554.
MIMi 300702. gene.
300765. gene.
neXtProti NX_Q96JG8.
PharmGKBi PA145148472.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG276522.
HOVERGENi HBG003714.
InParanoidi Q96JG8.
OMAi CAFSQAP.
OrthoDBi EOG75F4GM.
PhylomeDBi Q96JG8.
TreeFami TF352132.

Miscellaneous databases

ChiTaRSi MAGED4B. human.
GeneWikii MAGED4B.
NextBioi 126567.
PROi Q96JG8.
SOURCEi Search...

Gene expression databases

Bgeei Q96JG8.
CleanExi HS_MAGED4.
HS_MAGEE1.
Genevestigatori Q96JG8.

Family and domain databases

InterProi IPR002190. MAGE.
[Graphical view ]
PANTHERi PTHR11736. PTHR11736. 1 hit.
Pfami PF01454. MAGE. 1 hit.
[Graphical view ]
PROSITEi PS50838. MAGE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "MAGE-E1, a new member of the melanoma-associated antigen gene family and its expression in human glioma."
    Sasaki M., Nakahira K., Kawano Y., Katakura H., Yoshimine T., Shimizu K., Kim S.U., Ikenaka K.
    Cancer Res. 61:4809-4814(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3), TISSUE SPECIFICITY.
  2. "Structural characterization and chromosomal localization of the MAGE-E1 gene."
    Kawano Y., Sasaki M., Nakahira K., Yoshimine T., Shimizu K., Wada H., Ikenaka K.
    Gene 277:129-137(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS 1; 2 AND 3).
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Amygdala.
  4. "Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Nakayama M., Nakajima D., Kikuno R., Ohara O.
    DNA Res. 8:85-95(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  5. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
    Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.
    DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: SEQUENCE REVISION.
  6. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  7. "The DNA sequence of the human X chromosome."
    Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
    , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
    Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 4).
    Tissue: Brain, Eye and PNS.
  10. "Identification of a novel member of human Mage-D subfamily genes."
    Zhang C.
    Submitted (DEC-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 60-741.
  11. "Identification of new genes of the MAGE family."
    Lucas S., Boon T.
    Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 497-627.
    Tissue: Testis.
  12. "MAGED4-expression in renal cell carcinoma and identification of an HLA-A*25-restricted MHC class I ligand from solid tumor tissue."
    Kraemer B.F., Schoor O., Krueger T., Reichle C., Mueller M., Weinschenk T., Hennenlotter J., Stenzl A., Rammensee H.-G., Stevanovic S.
    Cancer Biol. Ther. 4:943-948(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  13. "MAGE-RING protein complexes comprise a family of E3 ubiquitin ligases."
    Doyle J.M., Gao J., Wang J., Yang M., Potts P.R.
    Mol. Cell 39:963-974(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH TRIM27.

Entry informationi

Entry nameiMAGD4_HUMAN
AccessioniPrimary (citable) accession number: Q96JG8
Secondary accession number(s): A8K093
, Q5HYN6, Q8WXW4, Q9BQ84, Q9BVH1, Q9BYH3, Q9BYH4, Q9H217
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: January 16, 2004
Last modified: July 9, 2014
This is version 104 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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