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Q96JG8

- MAGD4_HUMAN

UniProt

Q96JG8 - MAGD4_HUMAN

Protein

Melanoma-associated antigen D4

Gene

MAGED4

more
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 105 (01 Oct 2014)
      Sequence version 3 (16 Jan 2004)
      Previous versions | rss
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    Functioni

    May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex.1 Publication

    Keywords - Molecular functioni

    Tumor antigen

    Keywords - Biological processi

    Ubl conjugation pathway

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Melanoma-associated antigen D4
    Alternative name(s):
    MAGE-D4 antigen
    MAGE-E1 antigen
    Gene namesi
    Name:MAGED4
    Synonyms:KIAA1859, MAGED4A, MAGEE1
    AND
    Name:MAGED4B
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome X

    Organism-specific databases

    HGNCiHGNC:23793. MAGED4.
    HGNC:22880. MAGED4B.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA145148472.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 741741Melanoma-associated antigen D4PRO_0000156728Add
    BLAST

    Proteomic databases

    MaxQBiQ96JG8.
    PaxDbiQ96JG8.
    PRIDEiQ96JG8.

    PTM databases

    PhosphoSiteiQ96JG8.

    Expressioni

    Tissue specificityi

    Expressed only in brain and ovary among normal tissues. Isoform 1 and isoform 2 are specifically expressed in glioma cells among cancer cells. Detected in some renal cell carcinoma samples.2 Publications

    Gene expression databases

    BgeeiQ96JG8.
    CleanExiHS_MAGED4.
    HS_MAGEE1.
    GenevestigatoriQ96JG8.

    Organism-specific databases

    HPAiHPA003554.

    Interactioni

    Subunit structurei

    Interacts with TRIM27.1 Publication

    Protein-protein interaction databases

    BioGridi123521. 8 interactions.
    608671. 4 interactions.
    IntActiQ96JG8. 6 interactions.
    MINTiMINT-8247559.

    Structurei

    3D structure databases

    ProteinModelPortaliQ96JG8.
    SMRiQ96JG8. Positions 407-614.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini413 – 611199MAGEPROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi97 – 339243Ala-richAdd
    BLAST

    Sequence similaritiesi

    Contains 1 MAGE domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG276522.
    HOVERGENiHBG003714.
    InParanoidiQ96JG8.
    OMAiCAFSQAP.
    OrthoDBiEOG75F4GM.
    PhylomeDBiQ96JG8.
    TreeFamiTF352132.

    Family and domain databases

    InterProiIPR002190. MAGE.
    [Graphical view]
    PANTHERiPTHR11736. PTHR11736. 1 hit.
    PfamiPF01454. MAGE. 1 hit.
    [Graphical view]
    PROSITEiPS50838. MAGE. 1 hit.
    [Graphical view]

    Sequences (4)i

    Sequence statusi: Complete.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q96JG8-1) [UniParc]FASTAAdd to Basket

    Also known as: MAGE-E1a

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAEGSFSVQS ESYSVEDMDE GSDEVGEEEM VEGNDYEEFG AFGGYGTLTS    50
    FDIHILRAFG SLGPGLRILS NEPWELENPV LAQTLVEALQ LDPETLANET 100
    AARAANVARA AASNRAARAA AAAARTAFSQ VVASHRVATP QVSGEDTQPT 150
    TYAAEAQGPT PEPPLASPQT SQMLVTSKMA APEAPATSAQ SQTGSPAQEA 200
    ATEGPSSACA FSQAPCAREV DANRPSTAFL GQNDVFDFTQ PAGVSGMAFP 250
    RPKRPAPAQE AATEGPSAAS GVPQTGPGRE VAATRPKTTK SGKALAKTRW 300
    VEPQNVVAAA AAKAKMATSI PEPEGAAAAT AQHSAEPWAR MGGKRTKKSK 350
    HLDDEYESSE EERETPAVPP TWRASQPSLT VRAQLAPRPP MAPRSQIPSR 400
    HVLCLPPRNV TLLQERANKL VKYLMIKDYK KIPIKRADML KDVIREYDEH 450
    FPEIIERATY TLEKKFGIHL KEIDKEEHLY ILVCTRDSSA RLLGKTKDTP 500
    RLSLLLVILG VIFMNGNRAS EAVLWEALRK MGLRPGVRHP FLGDLRKLIT 550
    DDFVKQKYLE YKKIPNSNPP EYEFLWGLRA RHETSKMRVL RFIAQNQNRD 600
    PREWKAHFLE AVDDAFKTMD VDMAEEHARA QMRAQMNIGD EALIGRWSWD 650
    DIQVELLTWD EDGDFGDAWA RIPFAFWARY HQYILNSNRA NRRATWRAGV 700
    SSGTNGGAST SVLDGPSTSS TIRTRNAARA GASFFSWIQH R 741
    Length:741
    Mass (Da):81,378
    Last modified:January 16, 2004 - v3
    Checksum:i56B073324C12A8EC
    GO
    Isoform 2 (identifier: Q96JG8-2) [UniParc]FASTAAdd to Basket

    Also known as: MAGE-E1b

    The sequence of this isoform differs from the canonical sequence as follows:
         740-741: Missing.

    Show »
    Length:739
    Mass (Da):81,084
    Checksum:iA3324C12A8EC3BAB
    GO
    Isoform 3 (identifier: Q96JG8-3) [UniParc]FASTAAdd to Basket

    Also known as: MAGE-E1c

    The sequence of this isoform differs from the canonical sequence as follows:
         349-414: SKHLDDEYES...LPPRNVTLLQ → VRSPCPLPPP...LVHVSPTQVC
         415-741: Missing.

    Show »
    Length:414
    Mass (Da):42,774
    Checksum:i9E9B0351E0B580D8
    GO
    Isoform 4 (identifier: Q96JG8-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         557-557: K → KNPELREETPLSMAPSW

    Note: No experimental confirmation available.

    Show »
    Length:757
    Mass (Da):83,217
    Checksum:iC52971EDE25D26F0
    GO

    Sequence cautioni

    The sequence AAL50032.1 differs from that shown. Reason: Frameshift at positions 186 and 219.
    The sequence AAH01207.1 differs from that shown. Reason: Erroneous initiation.
    The sequence BAB47488.2 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti314 – 3141A → V in BAF82147. (PubMed:14702039)Curated
    Sequence conflicti635 – 6351Q → R1 PublicationCurated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei349 – 41466SKHLD…VTLLQ → VRSPCPLPPPHPLAPVLSFS SLSCSSPPSPLPLLPLFSSF PSFSPHLPSPPLLSSQLVHV SPTQVC in isoform 3. 1 PublicationVSP_009288Add
    BLAST
    Alternative sequencei415 – 741327Missing in isoform 3. 1 PublicationVSP_009289Add
    BLAST
    Alternative sequencei557 – 5571K → KNPELREETPLSMAPSW in isoform 4. 1 PublicationVSP_035013
    Alternative sequencei740 – 7412Missing in isoform 2. 1 PublicationVSP_009287

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB040527 mRNA. Translation: BAB33378.1.
    AB040528 mRNA. Translation: BAB33379.1.
    AB040529 mRNA. Translation: BAB33380.1.
    AB056059 Genomic DNA. Translation: BAB61778.1.
    AB056059 Genomic DNA. Translation: BAB61779.1.
    AB056059 Genomic DNA. Translation: BAB61780.1.
    AL136582 mRNA. Translation: CAB66517.1.
    AB058762 mRNA. Translation: BAB47488.2. Different initiation.
    AK289458 mRNA. Translation: BAF82147.1.
    AL928717 Genomic DNA. Translation: CAI40426.1.
    BX537154 Genomic DNA. Translation: CAI41307.1.
    CH471230 Genomic DNA. Translation: EAW62885.1.
    BC001207 mRNA. Translation: AAH01207.1. Different initiation.
    BC063838 mRNA. Translation: AAH63838.1.
    BC081566 mRNA. Translation: AAH81566.1.
    AF329733 mRNA. Translation: AAL50032.1. Frameshift.
    AF320908 mRNA. Translation: AAG38604.1.
    CCDSiCCDS14338.1. [Q96JG8-1]
    CCDS35281.1. [Q96JG8-2]
    CCDS48116.1. [Q96JG8-2]
    CCDS56602.1. [Q96JG8-4]
    CCDS65261.1. [Q96JG8-4]
    RefSeqiNP_001092270.1. NM_001098800.2. [Q96JG8-2]
    NP_001229291.1. NM_001242362.1. [Q96JG8-4]
    NP_001258990.1. NM_001272061.1. [Q96JG8-4]
    NP_001258991.1. NM_001272062.1. [Q96JG8-1]
    NP_001258992.1. NM_001272063.1. [Q96JG8-1]
    NP_110428.2. NM_030801.3. [Q96JG8-1]
    NP_803879.1. NM_177535.2. [Q96JG8-1]
    NP_803881.1. NM_177537.2. [Q96JG8-2]
    XP_006724670.1. XM_006724607.1. [Q96JG8-1]
    XP_006724671.1. XM_006724608.1. [Q96JG8-1]
    UniGeneiHs.522650.
    Hs.571729.
    Hs.733143.

    Genome annotation databases

    EnsembliENST00000335504; ENSP00000335385; ENSG00000187243. [Q96JG8-1]
    ENST00000360134; ENSP00000353252; ENSG00000187243. [Q96JG8-2]
    ENST00000375626; ENSP00000364777; ENSG00000154545. [Q96JG8-2]
    ENST00000485287; ENSP00000421861; ENSG00000187243. [Q96JG8-4]
    ENST00000497164; ENSP00000423848; ENSG00000187243. [Q96JG8-1]
    ENST00000599522; ENSP00000472118; ENSG00000154545. [Q96JG8-4]
    GeneIDi728239.
    81557.
    KEGGihsa:728239.
    hsa:81557.
    UCSCiuc004dpr.4. human. [Q96JG8-4]
    uc004dps.4. human. [Q96JG8-1]

    Polymorphism databases

    DMDMi41017391.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB040527 mRNA. Translation: BAB33378.1 .
    AB040528 mRNA. Translation: BAB33379.1 .
    AB040529 mRNA. Translation: BAB33380.1 .
    AB056059 Genomic DNA. Translation: BAB61778.1 .
    AB056059 Genomic DNA. Translation: BAB61779.1 .
    AB056059 Genomic DNA. Translation: BAB61780.1 .
    AL136582 mRNA. Translation: CAB66517.1 .
    AB058762 mRNA. Translation: BAB47488.2 . Different initiation.
    AK289458 mRNA. Translation: BAF82147.1 .
    AL928717 Genomic DNA. Translation: CAI40426.1 .
    BX537154 Genomic DNA. Translation: CAI41307.1 .
    CH471230 Genomic DNA. Translation: EAW62885.1 .
    BC001207 mRNA. Translation: AAH01207.1 . Different initiation.
    BC063838 mRNA. Translation: AAH63838.1 .
    BC081566 mRNA. Translation: AAH81566.1 .
    AF329733 mRNA. Translation: AAL50032.1 . Frameshift.
    AF320908 mRNA. Translation: AAG38604.1 .
    CCDSi CCDS14338.1. [Q96JG8-1 ]
    CCDS35281.1. [Q96JG8-2 ]
    CCDS48116.1. [Q96JG8-2 ]
    CCDS56602.1. [Q96JG8-4 ]
    CCDS65261.1. [Q96JG8-4 ]
    RefSeqi NP_001092270.1. NM_001098800.2. [Q96JG8-2 ]
    NP_001229291.1. NM_001242362.1. [Q96JG8-4 ]
    NP_001258990.1. NM_001272061.1. [Q96JG8-4 ]
    NP_001258991.1. NM_001272062.1. [Q96JG8-1 ]
    NP_001258992.1. NM_001272063.1. [Q96JG8-1 ]
    NP_110428.2. NM_030801.3. [Q96JG8-1 ]
    NP_803879.1. NM_177535.2. [Q96JG8-1 ]
    NP_803881.1. NM_177537.2. [Q96JG8-2 ]
    XP_006724670.1. XM_006724607.1. [Q96JG8-1 ]
    XP_006724671.1. XM_006724608.1. [Q96JG8-1 ]
    UniGenei Hs.522650.
    Hs.571729.
    Hs.733143.

    3D structure databases

    ProteinModelPortali Q96JG8.
    SMRi Q96JG8. Positions 407-614.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 123521. 8 interactions.
    608671. 4 interactions.
    IntActi Q96JG8. 6 interactions.
    MINTi MINT-8247559.

    PTM databases

    PhosphoSitei Q96JG8.

    Polymorphism databases

    DMDMi 41017391.

    Proteomic databases

    MaxQBi Q96JG8.
    PaxDbi Q96JG8.
    PRIDEi Q96JG8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000335504 ; ENSP00000335385 ; ENSG00000187243 . [Q96JG8-1 ]
    ENST00000360134 ; ENSP00000353252 ; ENSG00000187243 . [Q96JG8-2 ]
    ENST00000375626 ; ENSP00000364777 ; ENSG00000154545 . [Q96JG8-2 ]
    ENST00000485287 ; ENSP00000421861 ; ENSG00000187243 . [Q96JG8-4 ]
    ENST00000497164 ; ENSP00000423848 ; ENSG00000187243 . [Q96JG8-1 ]
    ENST00000599522 ; ENSP00000472118 ; ENSG00000154545 . [Q96JG8-4 ]
    GeneIDi 728239.
    81557.
    KEGGi hsa:728239.
    hsa:81557.
    UCSCi uc004dpr.4. human. [Q96JG8-4 ]
    uc004dps.4. human. [Q96JG8-1 ]

    Organism-specific databases

    CTDi 728239.
    81557.
    GeneCardsi GC0XM051822.
    GC0XP051927.
    HGNCi HGNC:23793. MAGED4.
    HGNC:22880. MAGED4B.
    HPAi HPA003554.
    MIMi 300702. gene.
    300765. gene.
    neXtProti NX_Q96JG8.
    PharmGKBi PA145148472.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG276522.
    HOVERGENi HBG003714.
    InParanoidi Q96JG8.
    OMAi CAFSQAP.
    OrthoDBi EOG75F4GM.
    PhylomeDBi Q96JG8.
    TreeFami TF352132.

    Miscellaneous databases

    ChiTaRSi MAGED4B. human.
    GeneWikii MAGED4B.
    NextBioi 126567.
    PROi Q96JG8.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q96JG8.
    CleanExi HS_MAGED4.
    HS_MAGEE1.
    Genevestigatori Q96JG8.

    Family and domain databases

    InterProi IPR002190. MAGE.
    [Graphical view ]
    PANTHERi PTHR11736. PTHR11736. 1 hit.
    Pfami PF01454. MAGE. 1 hit.
    [Graphical view ]
    PROSITEi PS50838. MAGE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "MAGE-E1, a new member of the melanoma-associated antigen gene family and its expression in human glioma."
      Sasaki M., Nakahira K., Kawano Y., Katakura H., Yoshimine T., Shimizu K., Kim S.U., Ikenaka K.
      Cancer Res. 61:4809-4814(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3), TISSUE SPECIFICITY.
    2. "Structural characterization and chromosomal localization of the MAGE-E1 gene."
      Kawano Y., Sasaki M., Nakahira K., Yoshimine T., Shimizu K., Wada H., Ikenaka K.
      Gene 277:129-137(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS 1; 2 AND 3).
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Amygdala.
    4. "Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
      Nagase T., Nakayama M., Nakajima D., Kikuno R., Ohara O.
      DNA Res. 8:85-95(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain.
    5. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
      Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.
      DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: SEQUENCE REVISION.
    6. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    7. "The DNA sequence of the human X chromosome."
      Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
      , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
      Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 4).
      Tissue: Brain, Eye and PNS.
    10. "Identification of a novel member of human Mage-D subfamily genes."
      Zhang C.
      Submitted (DEC-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 60-741.
    11. "Identification of new genes of the MAGE family."
      Lucas S., Boon T.
      Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 497-627.
      Tissue: Testis.
    12. "MAGED4-expression in renal cell carcinoma and identification of an HLA-A*25-restricted MHC class I ligand from solid tumor tissue."
      Kraemer B.F., Schoor O., Krueger T., Reichle C., Mueller M., Weinschenk T., Hennenlotter J., Stenzl A., Rammensee H.-G., Stevanovic S.
      Cancer Biol. Ther. 4:943-948(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.
    13. "MAGE-RING protein complexes comprise a family of E3 ubiquitin ligases."
      Doyle J.M., Gao J., Wang J., Yang M., Potts P.R.
      Mol. Cell 39:963-974(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH TRIM27.

    Entry informationi

    Entry nameiMAGD4_HUMAN
    AccessioniPrimary (citable) accession number: Q96JG8
    Secondary accession number(s): A8K093
    , Q5HYN6, Q8WXW4, Q9BQ84, Q9BVH1, Q9BYH3, Q9BYH4, Q9H217
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 16, 2004
    Last sequence update: January 16, 2004
    Last modified: October 1, 2014
    This is version 105 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome X
      Human chromosome X: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3