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Protein

Microtubule-associated protein 6

Gene

MAP6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in microtubule stabilization in many cell types, including neuronal cells. Specifically has microtubule cold stabilizing activity. Involved in dendrite morphogenesis and maintenance by regulating lysosomal trafficking via its interaction with TMEM106B.1 Publication

GO - Molecular functioni

GO - Biological processi

  • dendrite morphogenesis Source: UniProtKB
  • lysosome localization Source: UniProtKB
  • microtubule cytoskeleton organization Source: InterPro
  • transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

Calmodulin-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000171533-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Microtubule-associated protein 6
Short name:
MAP-6
Alternative name(s):
Stable tubule-only polypeptide
Short name:
STOP
Gene namesi
Name:MAP6
Synonyms:KIAA1878
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:6868. MAP6.

Subcellular locationi

  • Cytoplasmcytoskeleton 1 Publication
  • Golgi apparatus By similarity

  • Note: Colocalizes with neurofilament (NF)-rich inclusions in spinal chord and brain neurons of patients with amyotrophic lateral sclerosis (ALS).

GO - Cellular componenti

  • Golgi apparatus Source: UniProtKB-SubCell
  • microtubule Source: UniProtKB
  • perinuclear region of cytoplasm Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Golgi apparatus, Microtubule

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi71P → A: Inhibits interaction with ZDHHC13 and ZDHHC17. 1 Publication1

Organism-specific databases

DisGeNETi4135.
OpenTargetsiENSG00000171533.
PharmGKBiPA30614.

Polymorphism and mutation databases

BioMutaiMAP6.
DMDMi205830862.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003440441 – 813Microtubule-associated protein 6Add BLAST813

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi5S-palmitoyl cysteineBy similarity1
Lipidationi10S-palmitoyl cysteineBy similarity1
Lipidationi11S-palmitoyl cysteineBy similarity1
Modified residuei102PhosphoserineBy similarity1
Modified residuei143PhosphotyrosineBy similarity1
Modified residuei187PhosphoserineBy similarity1
Modified residuei812PhosphoserineBy similarity1

Keywords - PTMi

Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

EPDiQ96JE9.
PaxDbiQ96JE9.
PeptideAtlasiQ96JE9.
PRIDEiQ96JE9.

PTM databases

iPTMnetiQ96JE9.
PhosphoSitePlusiQ96JE9.

Expressioni

Tissue specificityi

Expressed in brain (at protein level). Expressed in spinal chord. Isoform 2 expression is up-regulated in the prefrontal cortex (Brodmann's area 46) of patients with schizophrenia (postmortem brain study).2 Publications

Gene expression databases

BgeeiENSG00000171533.
CleanExiHS_MAP6.
GenevisibleiQ96JE9. HS.

Organism-specific databases

HPAiCAB015442.
CAB022600.
HPA039061.
HPA039062.

Interactioni

Subunit structurei

Interacts with calmodulin (via C-terminus); the interaction is dependent on Ca2+ (By similarity). Interacts with TMEM106B (PubMed:24357581). Interacts with ZDHHC17 (via ANK repeats) (PubMed:26198635). Interacts with ZDHHC13 (via ANK repeats) (PubMed:26198635).By similarity2 Publications

GO - Molecular functioni

Protein-protein interaction databases

BioGridi110307. 3 interactors.
IntActiQ96JE9. 1 interactor.
STRINGi9606.ENSP00000307093.

Structurei

3D structure databases

ProteinModelPortaliQ96JE9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni118 – 141Mn 1Add BLAST24
Regioni126 – 140Calmodulin-bindingBy similarityAdd BLAST15
Regioni153 – 176Mn 2Add BLAST24
Regioni162 – 176Calmodulin-bindingBy similarityAdd BLAST15
Regioni189 – 203Calmodulin-bindingBy similarityAdd BLAST15
Regioni298 – 321Mn 3Add BLAST24
Regioni306 – 320Calmodulin-bindingBy similarityAdd BLAST15
Regioni357 – 371Calmodulin-bindingBy similarityAdd BLAST15
Regioni384 – 398Calmodulin-bindingBy similarityAdd BLAST15

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi43 – 49Poly-Pro7
Compositional biasi490 – 804Pro-richAdd BLAST315

Sequence similaritiesi

Belongs to the STOP family.Curated

Phylogenomic databases

eggNOGiENOG410IIA0. Eukaryota.
ENOG4110KV2. LUCA.
GeneTreeiENSGT00530000063947.
HOGENOMiHOG000113479.
HOVERGENiHBG053112.
InParanoidiQ96JE9.
KOiK10432.
OMAiRKAGPAW.
OrthoDBiEOG091G0A3G.
PhylomeDBiQ96JE9.
TreeFamiTF338320.

Family and domain databases

InterProiIPR007882. MAP6.
[Graphical view]
PANTHERiPTHR14759. PTHR14759. 2 hits.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96JE9-1) [UniParc]FASTAAdd to basket
Also known as: N-STOP, Neuronal-STOP

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAWPCITRAC CIARFWNQLD KADIAVPLVF TKYSEATEHP GAPPQPPPPQ
60 70 80 90 100
QQAQPALAPP SARAVAIETQ PAQGELDAVA RATGPAPGPT GEREPAAGPG
110 120 130 140 150
RSGPGPGLGS GSTSGPADSV MRQDYRAWKV QRPEPSCRPR SEYQPSDAPF
160 170 180 190 200
ERETQYQKDF RAWPLPRRGD HPWIPKPVQI SAASQASAPI LGAPKRRPQS
210 220 230 240 250
QERWPVQAAA EAREQEAAPG GAGGLAAGKA SGADERDTRR KAGPAWIVRR
260 270 280 290 300
AEGLGHEQTP LPAAQAQVQA TGPEAGRGRA AADALNRQIR EEVASAVSSS
310 320 330 340 350
YRNEFRAWTD IKPVKPIKAK PQYKPPDDKM VHETSYSAQF KGEASKPTTA
360 370 380 390 400
DNKVIDRRRI RSLYSEPFKE PPKVEKPSVQ SSKPKKTSAS HKPTRKAKDK
410 420 430 440 450
QAVSGQAAKK KSAEGPSTTK PDDKEQSKEM NNKLAEAKES LAQPVSDSSK
460 470 480 490 500
TQGPVATEPD KDQGSVVPGL LKGQGPMVQE PLKKQGSVVP GPPKDLGPMI
510 520 530 540 550
PLPVKDQDHT VPEPLKNESP VISAPVKDQG PSVPVPPKNQ SPMVPAKVKD
560 570 580 590 600
QGSVVPESLK DQGPRIPEPV KNQAPMVPAP VKDEGPMVSA SVKDQGPMVS
610 620 630 640 650
APVKDQGPIV PAPVKGEGPI VPAPVKDEGP MVSAPIKDQD PMVPEHPKDE
660 670 680 690 700
SAMATAPIKN QGSMVSEPVK NQGLVVSGPV KDQDVVVPEH AKVHDSAVVA
710 720 730 740 750
PVKNQGPVVP ESVKNQDPIL PVLVKDQGPT VLQPPKNQGR IVPEPLKNQV
760 770 780 790 800
PIVPVPLKDQ DPLVPVPAKD QGPAVPEPLK TQGPRDPQLP TVSPLPRVMI
810
PTAPHTEYIE SSP
Length:813
Mass (Da):86,505
Last modified:July 22, 2008 - v2
Checksum:i9680ACAFDB5694D1
GO
Isoform 2 (identifier: Q96JE9-2) [UniParc]FASTAAdd to basket
Also known as: E-STOP, Early-STOP

The sequence of this isoform differs from the canonical sequence as follows:
     440-813: Missing.

Show »
Length:439
Mass (Da):47,376
Checksum:i3FBA4647C7906F89
GO
Isoform 3 (identifier: Q96JE9-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-329: Missing.

Note: No experimental confirmation available.
Show »
Length:484
Mass (Da):51,329
Checksum:iF49849A9813B336C
GO

Sequence cautioni

The sequence AAH63860 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_044542247I → M.1 PublicationCorresponds to variant rs12225010dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0541511 – 329Missing in isoform 3. 2 PublicationsAdd BLAST329
Alternative sequenceiVSP_034723440 – 813Missing in isoform 2. 1 PublicationAdd BLAST374

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK123340 mRNA. Translation: BAC85586.1.
AP001922 Genomic DNA. No translation available.
BC063860 mRNA. Translation: AAH63860.1. Different initiation.
BC139780 mRNA. Translation: AAI39781.1.
BC150254 mRNA. Translation: AAI50255.1.
AB058781 mRNA. Translation: BAB47507.1.
CCDSiCCDS31641.1. [Q96JE9-1]
CCDS44686.1. [Q96JE9-2]
RefSeqiNP_149052.1. NM_033063.1. [Q96JE9-1]
NP_997460.1. NM_207577.1. [Q96JE9-2]
UniGeneiHs.585540.

Genome annotation databases

EnsembliENST00000304771; ENSP00000307093; ENSG00000171533. [Q96JE9-1]
ENST00000434603; ENSP00000415108; ENSG00000171533. [Q96JE9-2]
ENST00000526740; ENSP00000434278; ENSG00000171533. [Q96JE9-3]
GeneIDi4135.
KEGGihsa:4135.
UCSCiuc001owu.4. human. [Q96JE9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK123340 mRNA. Translation: BAC85586.1.
AP001922 Genomic DNA. No translation available.
BC063860 mRNA. Translation: AAH63860.1. Different initiation.
BC139780 mRNA. Translation: AAI39781.1.
BC150254 mRNA. Translation: AAI50255.1.
AB058781 mRNA. Translation: BAB47507.1.
CCDSiCCDS31641.1. [Q96JE9-1]
CCDS44686.1. [Q96JE9-2]
RefSeqiNP_149052.1. NM_033063.1. [Q96JE9-1]
NP_997460.1. NM_207577.1. [Q96JE9-2]
UniGeneiHs.585540.

3D structure databases

ProteinModelPortaliQ96JE9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110307. 3 interactors.
IntActiQ96JE9. 1 interactor.
STRINGi9606.ENSP00000307093.

PTM databases

iPTMnetiQ96JE9.
PhosphoSitePlusiQ96JE9.

Polymorphism and mutation databases

BioMutaiMAP6.
DMDMi205830862.

Proteomic databases

EPDiQ96JE9.
PaxDbiQ96JE9.
PeptideAtlasiQ96JE9.
PRIDEiQ96JE9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000304771; ENSP00000307093; ENSG00000171533. [Q96JE9-1]
ENST00000434603; ENSP00000415108; ENSG00000171533. [Q96JE9-2]
ENST00000526740; ENSP00000434278; ENSG00000171533. [Q96JE9-3]
GeneIDi4135.
KEGGihsa:4135.
UCSCiuc001owu.4. human. [Q96JE9-1]

Organism-specific databases

CTDi4135.
DisGeNETi4135.
GeneCardsiMAP6.
H-InvDBHIX0009952.
HIX0171354.
HGNCiHGNC:6868. MAP6.
HPAiCAB015442.
CAB022600.
HPA039061.
HPA039062.
MIMi601783. gene.
neXtProtiNX_Q96JE9.
OpenTargetsiENSG00000171533.
PharmGKBiPA30614.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IIA0. Eukaryota.
ENOG4110KV2. LUCA.
GeneTreeiENSGT00530000063947.
HOGENOMiHOG000113479.
HOVERGENiHBG053112.
InParanoidiQ96JE9.
KOiK10432.
OMAiRKAGPAW.
OrthoDBiEOG091G0A3G.
PhylomeDBiQ96JE9.
TreeFamiTF338320.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000171533-MONOMER.

Miscellaneous databases

GeneWikiiMAP6.
GenomeRNAii4135.
PROiQ96JE9.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000171533.
CleanExiHS_MAP6.
GenevisibleiQ96JE9. HS.

Family and domain databases

InterProiIPR007882. MAP6.
[Graphical view]
PANTHERiPTHR14759. PTHR14759. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiMAP6_HUMAN
AccessioniPrimary (citable) accession number: Q96JE9
Secondary accession number(s): A7E2A1, Q6P3T0, Q6ZWB8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: July 22, 2008
Last modified: November 2, 2016
This is version 102 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.