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Q96JE9

- MAP6_HUMAN

UniProt

Q96JE9 - MAP6_HUMAN

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Protein

Microtubule-associated protein 6

Gene
MAP6, KIAA1878
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Involved in microtubule stabilization in many cell types, including neuronal cells. Specifically has microtubule cold stabilizing activity. Involved in dendrite morphogenesis and maintenance by regulating lysosomal trafficking via its interaction with TMEM106B.1 Publication

GO - Molecular functioni

  1. protein binding Source: UniProtKB

GO - Biological processi

  1. dendrite morphogenesis Source: UniProtKB
  2. lysosome localization Source: UniProtKB
  3. microtubule cytoskeleton organization Source: InterPro
  4. transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

Calmodulin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Microtubule-associated protein 6
Short name:
MAP-6
Alternative name(s):
Stable tubule-only polypeptide
Short name:
STOP
Gene namesi
Name:MAP6
Synonyms:KIAA1878
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:6868. MAP6.

Subcellular locationi

Cytoplasmcytoskeleton. Golgi apparatus By similarity
Note: Colocalizes with neurofilament (NF)-rich inclusions in spinal chord and brain neurons of patients with amyotrophic lateral sclerosis (ALS).1 Publication

GO - Cellular componenti

  1. Golgi apparatus Source: UniProtKB-SubCell
  2. microtubule Source: UniProtKB
  3. perinuclear region of cytoplasm Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Golgi apparatus, Microtubule

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30614.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 813813Microtubule-associated protein 6PRO_0000344044Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi5 – 51S-palmitoyl cysteine By similarity
Lipidationi10 – 101S-palmitoyl cysteine By similarity
Lipidationi11 – 111S-palmitoyl cysteine By similarity
Modified residuei143 – 1431Phosphotyrosine By similarity

Keywords - PTMi

Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

PaxDbiQ96JE9.
PRIDEiQ96JE9.

PTM databases

PhosphoSiteiQ96JE9.

Expressioni

Tissue specificityi

Expressed in brain (at protein level). Expressed in spinal chord. Isoform 2 expression is up-regulated in the prefrontal cortex (Brodmann's area 46) of patients with schizophrenia (postmortem brain study).2 Publications

Gene expression databases

ArrayExpressiQ96JE9.
BgeeiQ96JE9.
CleanExiHS_MAP6.
GenevestigatoriQ96JE9.

Organism-specific databases

HPAiCAB015442.
CAB022600.
HPA039061.
HPA039062.

Interactioni

Subunit structurei

Interacts with calmodulin (via C-terminus); the interaction is dependent on Ca2+ By similarity. Interacts with TMEM106B.1 Publication

Protein-protein interaction databases

BioGridi110307. 3 interactions.
IntActiQ96JE9. 1 interaction.
STRINGi9606.ENSP00000307093.

Structurei

3D structure databases

ProteinModelPortaliQ96JE9.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni118 – 14124Mn 1Add
BLAST
Regioni126 – 14015Calmodulin-binding By similarityAdd
BLAST
Regioni153 – 17624Mn 2Add
BLAST
Regioni162 – 17615Calmodulin-binding By similarityAdd
BLAST
Regioni189 – 20315Calmodulin-binding By similarityAdd
BLAST
Regioni298 – 32124Mn 3Add
BLAST
Regioni306 – 32015Calmodulin-binding By similarityAdd
BLAST
Regioni357 – 37115Calmodulin-binding By similarityAdd
BLAST
Regioni384 – 39815Calmodulin-binding By similarityAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi43 – 497Poly-Pro
Compositional biasi490 – 804315Pro-richAdd
BLAST

Sequence similaritiesi

Belongs to the STOP family.

Phylogenomic databases

eggNOGiNOG87903.
HOGENOMiHOG000113479.
HOVERGENiHBG053112.
InParanoidiQ96JE9.
KOiK10432.
OMAiRKAGPAW.
OrthoDBiEOG7ZWD1D.
PhylomeDBiQ96JE9.
TreeFamiTF338320.

Family and domain databases

InterProiIPR007882. MAP6.
IPR024963. MAP6/FAM154.
[Graphical view]
PANTHERiPTHR14759. PTHR14759. 1 hit.
PfamiPF05217. STOP. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q96JE9-1) [UniParc]FASTAAdd to Basket

Also known as: N-STOP, Neuronal-STOP

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MAWPCITRAC CIARFWNQLD KADIAVPLVF TKYSEATEHP GAPPQPPPPQ    50
QQAQPALAPP SARAVAIETQ PAQGELDAVA RATGPAPGPT GEREPAAGPG 100
RSGPGPGLGS GSTSGPADSV MRQDYRAWKV QRPEPSCRPR SEYQPSDAPF 150
ERETQYQKDF RAWPLPRRGD HPWIPKPVQI SAASQASAPI LGAPKRRPQS 200
QERWPVQAAA EAREQEAAPG GAGGLAAGKA SGADERDTRR KAGPAWIVRR 250
AEGLGHEQTP LPAAQAQVQA TGPEAGRGRA AADALNRQIR EEVASAVSSS 300
YRNEFRAWTD IKPVKPIKAK PQYKPPDDKM VHETSYSAQF KGEASKPTTA 350
DNKVIDRRRI RSLYSEPFKE PPKVEKPSVQ SSKPKKTSAS HKPTRKAKDK 400
QAVSGQAAKK KSAEGPSTTK PDDKEQSKEM NNKLAEAKES LAQPVSDSSK 450
TQGPVATEPD KDQGSVVPGL LKGQGPMVQE PLKKQGSVVP GPPKDLGPMI 500
PLPVKDQDHT VPEPLKNESP VISAPVKDQG PSVPVPPKNQ SPMVPAKVKD 550
QGSVVPESLK DQGPRIPEPV KNQAPMVPAP VKDEGPMVSA SVKDQGPMVS 600
APVKDQGPIV PAPVKGEGPI VPAPVKDEGP MVSAPIKDQD PMVPEHPKDE 650
SAMATAPIKN QGSMVSEPVK NQGLVVSGPV KDQDVVVPEH AKVHDSAVVA 700
PVKNQGPVVP ESVKNQDPIL PVLVKDQGPT VLQPPKNQGR IVPEPLKNQV 750
PIVPVPLKDQ DPLVPVPAKD QGPAVPEPLK TQGPRDPQLP TVSPLPRVMI 800
PTAPHTEYIE SSP 813
Length:813
Mass (Da):86,505
Last modified:July 22, 2008 - v2
Checksum:i9680ACAFDB5694D1
GO
Isoform 2 (identifier: Q96JE9-2) [UniParc]FASTAAdd to Basket

Also known as: E-STOP, Early-STOP

The sequence of this isoform differs from the canonical sequence as follows:
     440-813: Missing.

Show »
Length:439
Mass (Da):47,376
Checksum:i3FBA4647C7906F89
GO
Isoform 3 (identifier: Q96JE9-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-329: Missing.

Note: No experimental confirmation available.

Show »
Length:484
Mass (Da):51,329
Checksum:iF49849A9813B336C
GO

Sequence cautioni

The sequence AAH63860.1 differs from that shown. Reason: Erroneous initiation.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti247 – 2471I → M.1 Publication
Corresponds to variant rs12225010 [ dbSNP | Ensembl ].
VAR_044542

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 329329Missing in isoform 3. VSP_054151Add
BLAST
Alternative sequencei440 – 813374Missing in isoform 2. VSP_034723Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK123340 mRNA. Translation: BAC85586.1.
AP001922 Genomic DNA. No translation available.
BC063860 mRNA. Translation: AAH63860.1. Different initiation.
BC139780 mRNA. Translation: AAI39781.1.
BC150254 mRNA. Translation: AAI50255.1.
AB058781 mRNA. Translation: BAB47507.1.
CCDSiCCDS31641.1. [Q96JE9-1]
CCDS44686.1. [Q96JE9-2]
RefSeqiNP_149052.1. NM_033063.1. [Q96JE9-1]
NP_997460.1. NM_207577.1. [Q96JE9-2]
UniGeneiHs.585540.

Genome annotation databases

EnsembliENST00000304771; ENSP00000307093; ENSG00000171533. [Q96JE9-1]
ENST00000434603; ENSP00000415108; ENSG00000171533. [Q96JE9-2]
ENST00000526740; ENSP00000434278; ENSG00000171533.
GeneIDi4135.
KEGGihsa:4135.
UCSCiuc001owu.3. human. [Q96JE9-1]

Polymorphism databases

DMDMi205830862.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK123340 mRNA. Translation: BAC85586.1 .
AP001922 Genomic DNA. No translation available.
BC063860 mRNA. Translation: AAH63860.1 . Different initiation.
BC139780 mRNA. Translation: AAI39781.1 .
BC150254 mRNA. Translation: AAI50255.1 .
AB058781 mRNA. Translation: BAB47507.1 .
CCDSi CCDS31641.1. [Q96JE9-1 ]
CCDS44686.1. [Q96JE9-2 ]
RefSeqi NP_149052.1. NM_033063.1. [Q96JE9-1 ]
NP_997460.1. NM_207577.1. [Q96JE9-2 ]
UniGenei Hs.585540.

3D structure databases

ProteinModelPortali Q96JE9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 110307. 3 interactions.
IntActi Q96JE9. 1 interaction.
STRINGi 9606.ENSP00000307093.

PTM databases

PhosphoSitei Q96JE9.

Polymorphism databases

DMDMi 205830862.

Proteomic databases

PaxDbi Q96JE9.
PRIDEi Q96JE9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000304771 ; ENSP00000307093 ; ENSG00000171533 . [Q96JE9-1 ]
ENST00000434603 ; ENSP00000415108 ; ENSG00000171533 . [Q96JE9-2 ]
ENST00000526740 ; ENSP00000434278 ; ENSG00000171533 .
GeneIDi 4135.
KEGGi hsa:4135.
UCSCi uc001owu.3. human. [Q96JE9-1 ]

Organism-specific databases

CTDi 4135.
GeneCardsi GC11M075297.
H-InvDB HIX0009952.
HIX0171354.
HGNCi HGNC:6868. MAP6.
HPAi CAB015442.
CAB022600.
HPA039061.
HPA039062.
MIMi 601783. gene.
neXtProti NX_Q96JE9.
PharmGKBi PA30614.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG87903.
HOGENOMi HOG000113479.
HOVERGENi HBG053112.
InParanoidi Q96JE9.
KOi K10432.
OMAi RKAGPAW.
OrthoDBi EOG7ZWD1D.
PhylomeDBi Q96JE9.
TreeFami TF338320.

Miscellaneous databases

GeneWikii MAP6.
GenomeRNAii 4135.
NextBioi 16240.
PROi Q96JE9.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q96JE9.
Bgeei Q96JE9.
CleanExi HS_MAP6.
Genevestigatori Q96JE9.

Family and domain databases

InterProi IPR007882. MAP6.
IPR024963. MAP6/FAM154.
[Graphical view ]
PANTHERi PTHR14759. PTHR14759. 1 hit.
Pfami PF05217. STOP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Brain.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3), VARIANT MET-247.
    Tissue: PNS.
  4. "Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Nakayama M., Nakajima D., Kikuno R., Ohara O.
    DNA Res. 8:85-95(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 91-813 (ISOFORM 1).
    Tissue: Brain.
  5. "Stable tubule only polypeptides (STOP) proteins co-aggregate with spheroid neurofilaments in amyotrophic lateral sclerosis."
    Letournel F., Bocquet A., Dubas F., Barthelaix A., Eyer J.
    J. Neuropathol. Exp. Neurol. 62:1211-1219(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  6. Cited for: TISSUE SPECIFICITY.
  7. "The FTLD risk factor TMEM106B and MAP6 control dendritic trafficking of lysosomes."
    Schwenk B.M., Lang C.M., Hogl S., Tahirovic S., Orozco D., Rentzsch K., Lichtenthaler S.F., Hoogenraad C.C., Capell A., Haass C., Edbauer D.
    EMBO J. 33:450-467(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH TMEM106B.

Entry informationi

Entry nameiMAP6_HUMAN
AccessioniPrimary (citable) accession number: Q96JE9
Secondary accession number(s): A7E2A1, Q6P3T0, Q6ZWB8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: July 22, 2008
Last modified: September 3, 2014
This is version 83 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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