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Q96JE9 (MAP6_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 82. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Microtubule-associated protein 6

Short name=MAP-6
Alternative name(s):
Stable tubule-only polypeptide
Short name=STOP
Gene names
Name:MAP6
Synonyms:KIAA1878
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length813 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Involved in microtubule stabilization in many cell types, including neuronal cells. Specifically has microtubule cold stabilizing activity. Involved in dendrite morphogenesis and maintenance by regulating lysosomal trafficking via its interaction with TMEM106B. Ref.7

Subunit structure

Interacts with calmodulin (via C-terminus); the interaction is dependent on Ca2+ By similarity. Interacts with TMEM106B. Ref.7

Subcellular location

Cytoplasmcytoskeleton. Golgi apparatus By similarity. Note: Colocalizes with neurofilament (NF)-rich inclusions in spinal chord and brain neurons of patients with amyotrophic lateral sclerosis (ALS). Ref.5

Tissue specificity

Expressed in brain (at protein level). Expressed in spinal chord. Isoform 2 expression is up-regulated in the prefrontal cortex (Brodmann's area 46) of patients with schizophrenia (postmortem brain study). Ref.5 Ref.6

Sequence similarities

Belongs to the STOP family.

Sequence caution

The sequence AAH63860.1 differs from that shown. Reason: Erroneous initiation.

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q96JE9-1)

Also known as: N-STOP; Neuronal-STOP;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q96JE9-2)

Also known as: E-STOP; Early-STOP;

The sequence of this isoform differs from the canonical sequence as follows:
     440-813: Missing.
Isoform 3 (identifier: Q96JE9-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-329: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 813813Microtubule-associated protein 6
PRO_0000344044

Regions

Region118 – 14124Mn 1
Region126 – 14015Calmodulin-binding By similarity
Region153 – 17624Mn 2
Region162 – 17615Calmodulin-binding By similarity
Region189 – 20315Calmodulin-binding By similarity
Region298 – 32124Mn 3
Region306 – 32015Calmodulin-binding By similarity
Region357 – 37115Calmodulin-binding By similarity
Region384 – 39815Calmodulin-binding By similarity
Compositional bias43 – 497Poly-Pro
Compositional bias490 – 804315Pro-rich

Amino acid modifications

Modified residue1431Phosphotyrosine By similarity
Lipidation51S-palmitoyl cysteine By similarity
Lipidation101S-palmitoyl cysteine By similarity
Lipidation111S-palmitoyl cysteine By similarity

Natural variations

Alternative sequence1 – 329329Missing in isoform 3.
VSP_054151
Alternative sequence440 – 813374Missing in isoform 2.
VSP_034723
Natural variant2471I → M. Ref.3
Corresponds to variant rs12225010 [ dbSNP | Ensembl ].
VAR_044542

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 (N-STOP) (Neuronal-STOP) [UniParc].

Last modified July 22, 2008. Version 2.
Checksum: 9680ACAFDB5694D1

FASTA81386,505
        10         20         30         40         50         60 
MAWPCITRAC CIARFWNQLD KADIAVPLVF TKYSEATEHP GAPPQPPPPQ QQAQPALAPP 

        70         80         90        100        110        120 
SARAVAIETQ PAQGELDAVA RATGPAPGPT GEREPAAGPG RSGPGPGLGS GSTSGPADSV 

       130        140        150        160        170        180 
MRQDYRAWKV QRPEPSCRPR SEYQPSDAPF ERETQYQKDF RAWPLPRRGD HPWIPKPVQI 

       190        200        210        220        230        240 
SAASQASAPI LGAPKRRPQS QERWPVQAAA EAREQEAAPG GAGGLAAGKA SGADERDTRR 

       250        260        270        280        290        300 
KAGPAWIVRR AEGLGHEQTP LPAAQAQVQA TGPEAGRGRA AADALNRQIR EEVASAVSSS 

       310        320        330        340        350        360 
YRNEFRAWTD IKPVKPIKAK PQYKPPDDKM VHETSYSAQF KGEASKPTTA DNKVIDRRRI 

       370        380        390        400        410        420 
RSLYSEPFKE PPKVEKPSVQ SSKPKKTSAS HKPTRKAKDK QAVSGQAAKK KSAEGPSTTK 

       430        440        450        460        470        480 
PDDKEQSKEM NNKLAEAKES LAQPVSDSSK TQGPVATEPD KDQGSVVPGL LKGQGPMVQE 

       490        500        510        520        530        540 
PLKKQGSVVP GPPKDLGPMI PLPVKDQDHT VPEPLKNESP VISAPVKDQG PSVPVPPKNQ 

       550        560        570        580        590        600 
SPMVPAKVKD QGSVVPESLK DQGPRIPEPV KNQAPMVPAP VKDEGPMVSA SVKDQGPMVS 

       610        620        630        640        650        660 
APVKDQGPIV PAPVKGEGPI VPAPVKDEGP MVSAPIKDQD PMVPEHPKDE SAMATAPIKN 

       670        680        690        700        710        720 
QGSMVSEPVK NQGLVVSGPV KDQDVVVPEH AKVHDSAVVA PVKNQGPVVP ESVKNQDPIL 

       730        740        750        760        770        780 
PVLVKDQGPT VLQPPKNQGR IVPEPLKNQV PIVPVPLKDQ DPLVPVPAKD QGPAVPEPLK 

       790        800        810 
TQGPRDPQLP TVSPLPRVMI PTAPHTEYIE SSP 

« Hide

Isoform 2 (E-STOP) (Early-STOP) [UniParc].

Checksum: 3FBA4647C7906F89
Show »

FASTA43947,376
Isoform 3 [UniParc].

Checksum: F49849A9813B336C
Show »

FASTA48451,329

References

« Hide 'large scale' references
[1]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
Tissue: Brain.
[2]"Human chromosome 11 DNA sequence and analysis including novel gene identification."
Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G. expand/collapse author list , Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S., Sakaki Y.
Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3), VARIANT MET-247.
Tissue: PNS.
[4]"Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
Nagase T., Nakayama M., Nakajima D., Kikuno R., Ohara O.
DNA Res. 8:85-95(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 91-813 (ISOFORM 1).
Tissue: Brain.
[5]"Stable tubule only polypeptides (STOP) proteins co-aggregate with spheroid neurofilaments in amyotrophic lateral sclerosis."
Letournel F., Bocquet A., Dubas F., Barthelaix A., Eyer J.
J. Neuropathol. Exp. Neurol. 62:1211-1219(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
[6]"Genetic and expression analyses of the STOP (MAP6) gene in schizophrenia."
Shimizu H., Iwayama Y., Yamada K., Toyota T., Minabe Y., Nakamura K., Nakajima M., Hattori E., Mori N., Osumi N., Yoshikawa T.
Schizophr. Res. 84:244-252(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY.
[7]"The FTLD risk factor TMEM106B and MAP6 control dendritic trafficking of lysosomes."
Schwenk B.M., Lang C.M., Hogl S., Tahirovic S., Orozco D., Rentzsch K., Lichtenthaler S.F., Hoogenraad C.C., Capell A., Haass C., Edbauer D.
EMBO J. 33:450-467(2014) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, INTERACTION WITH TMEM106B.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK123340 mRNA. Translation: BAC85586.1.
AP001922 Genomic DNA. No translation available.
BC063860 mRNA. Translation: AAH63860.1. Different initiation.
BC139780 mRNA. Translation: AAI39781.1.
BC150254 mRNA. Translation: AAI50255.1.
AB058781 mRNA. Translation: BAB47507.1.
CCDSCCDS31641.1. [Q96JE9-1]
CCDS44686.1. [Q96JE9-2]
RefSeqNP_149052.1. NM_033063.1. [Q96JE9-1]
NP_997460.1. NM_207577.1. [Q96JE9-2]
UniGeneHs.585540.

3D structure databases

ProteinModelPortalQ96JE9.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid110307. 3 interactions.
STRING9606.ENSP00000307093.

PTM databases

PhosphoSiteQ96JE9.

Polymorphism databases

DMDM205830862.

Proteomic databases

PaxDbQ96JE9.
PRIDEQ96JE9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000304771; ENSP00000307093; ENSG00000171533. [Q96JE9-1]
ENST00000434603; ENSP00000415108; ENSG00000171533. [Q96JE9-2]
ENST00000526740; ENSP00000434278; ENSG00000171533.
GeneID4135.
KEGGhsa:4135.
UCSCuc001owu.3. human. [Q96JE9-1]

Organism-specific databases

CTD4135.
GeneCardsGC11M075297.
H-InvDBHIX0009952.
HIX0171354.
HGNCHGNC:6868. MAP6.
HPACAB015442.
CAB022600.
HPA039061.
HPA039062.
MIM601783. gene.
neXtProtNX_Q96JE9.
PharmGKBPA30614.
HUGESearch...
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG87903.
HOGENOMHOG000113479.
HOVERGENHBG053112.
InParanoidQ96JE9.
KOK10432.
OMARKAGPAW.
OrthoDBEOG7ZWD1D.
PhylomeDBQ96JE9.
TreeFamTF338320.

Gene expression databases

ArrayExpressQ96JE9.
BgeeQ96JE9.
CleanExHS_MAP6.
GenevestigatorQ96JE9.

Family and domain databases

InterProIPR007882. MAP6.
IPR024963. MAP6/FAM154.
[Graphical view]
PANTHERPTHR14759. PTHR14759. 1 hit.
PfamPF05217. STOP. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiMAP6.
GenomeRNAi4135.
NextBio16240.
PROQ96JE9.
SOURCESearch...

Entry information

Entry nameMAP6_HUMAN
AccessionPrimary (citable) accession number: Q96JE9
Secondary accession number(s): A7E2A1, Q6P3T0, Q6ZWB8
Entry history
Integrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: July 22, 2008
Last modified: July 9, 2014
This is version 82 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM