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Q96JE9

- MAP6_HUMAN

UniProt

Q96JE9 - MAP6_HUMAN

Protein

Microtubule-associated protein 6

Gene

MAP6

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 84 (01 Oct 2014)
      Sequence version 2 (22 Jul 2008)
      Previous versions | rss
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    Functioni

    Involved in microtubule stabilization in many cell types, including neuronal cells. Specifically has microtubule cold stabilizing activity. Involved in dendrite morphogenesis and maintenance by regulating lysosomal trafficking via its interaction with TMEM106B.1 Publication

    GO - Molecular functioni

    1. protein binding Source: UniProtKB

    GO - Biological processi

    1. dendrite morphogenesis Source: UniProtKB
    2. lysosome localization Source: UniProtKB
    3. microtubule cytoskeleton organization Source: InterPro
    4. transport Source: UniProtKB-KW

    Keywords - Biological processi

    Transport

    Keywords - Ligandi

    Calmodulin-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Microtubule-associated protein 6
    Short name:
    MAP-6
    Alternative name(s):
    Stable tubule-only polypeptide
    Short name:
    STOP
    Gene namesi
    Name:MAP6
    Synonyms:KIAA1878
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:6868. MAP6.

    Subcellular locationi

    Cytoplasmcytoskeleton 1 Publication. Golgi apparatus By similarity
    Note: Colocalizes with neurofilament (NF)-rich inclusions in spinal chord and brain neurons of patients with amyotrophic lateral sclerosis (ALS).

    GO - Cellular componenti

    1. Golgi apparatus Source: UniProtKB-SubCell
    2. microtubule Source: UniProtKB
    3. perinuclear region of cytoplasm Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm, Cytoskeleton, Golgi apparatus, Microtubule

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA30614.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 813813Microtubule-associated protein 6PRO_0000344044Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Lipidationi5 – 51S-palmitoyl cysteineBy similarity
    Lipidationi10 – 101S-palmitoyl cysteineBy similarity
    Lipidationi11 – 111S-palmitoyl cysteineBy similarity
    Modified residuei143 – 1431PhosphotyrosineBy similarity

    Keywords - PTMi

    Lipoprotein, Palmitate, Phosphoprotein

    Proteomic databases

    PaxDbiQ96JE9.
    PRIDEiQ96JE9.

    PTM databases

    PhosphoSiteiQ96JE9.

    Expressioni

    Tissue specificityi

    Expressed in brain (at protein level). Expressed in spinal chord. Isoform 2 expression is up-regulated in the prefrontal cortex (Brodmann's area 46) of patients with schizophrenia (postmortem brain study).2 Publications

    Gene expression databases

    ArrayExpressiQ96JE9.
    BgeeiQ96JE9.
    CleanExiHS_MAP6.
    GenevestigatoriQ96JE9.

    Organism-specific databases

    HPAiCAB015442.
    CAB022600.
    HPA039061.
    HPA039062.

    Interactioni

    Subunit structurei

    Interacts with calmodulin (via C-terminus); the interaction is dependent on Ca2+ By similarity. Interacts with TMEM106B.By similarity1 Publication

    Protein-protein interaction databases

    BioGridi110307. 3 interactions.
    IntActiQ96JE9. 1 interaction.
    STRINGi9606.ENSP00000307093.

    Structurei

    3D structure databases

    ProteinModelPortaliQ96JE9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni118 – 14124Mn 1Add
    BLAST
    Regioni126 – 14015Calmodulin-bindingBy similarityAdd
    BLAST
    Regioni153 – 17624Mn 2Add
    BLAST
    Regioni162 – 17615Calmodulin-bindingBy similarityAdd
    BLAST
    Regioni189 – 20315Calmodulin-bindingBy similarityAdd
    BLAST
    Regioni298 – 32124Mn 3Add
    BLAST
    Regioni306 – 32015Calmodulin-bindingBy similarityAdd
    BLAST
    Regioni357 – 37115Calmodulin-bindingBy similarityAdd
    BLAST
    Regioni384 – 39815Calmodulin-bindingBy similarityAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi43 – 497Poly-Pro
    Compositional biasi490 – 804315Pro-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the STOP family.Curated

    Phylogenomic databases

    eggNOGiNOG87903.
    HOGENOMiHOG000113479.
    HOVERGENiHBG053112.
    InParanoidiQ96JE9.
    KOiK10432.
    OMAiRKAGPAW.
    OrthoDBiEOG7ZWD1D.
    PhylomeDBiQ96JE9.
    TreeFamiTF338320.

    Family and domain databases

    InterProiIPR007882. MAP6.
    IPR024963. MAP6/FAM154.
    [Graphical view]
    PANTHERiPTHR14759. PTHR14759. 1 hit.
    PfamiPF05217. STOP. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q96JE9-1) [UniParc]FASTAAdd to Basket

    Also known as: N-STOP, Neuronal-STOP

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAWPCITRAC CIARFWNQLD KADIAVPLVF TKYSEATEHP GAPPQPPPPQ    50
    QQAQPALAPP SARAVAIETQ PAQGELDAVA RATGPAPGPT GEREPAAGPG 100
    RSGPGPGLGS GSTSGPADSV MRQDYRAWKV QRPEPSCRPR SEYQPSDAPF 150
    ERETQYQKDF RAWPLPRRGD HPWIPKPVQI SAASQASAPI LGAPKRRPQS 200
    QERWPVQAAA EAREQEAAPG GAGGLAAGKA SGADERDTRR KAGPAWIVRR 250
    AEGLGHEQTP LPAAQAQVQA TGPEAGRGRA AADALNRQIR EEVASAVSSS 300
    YRNEFRAWTD IKPVKPIKAK PQYKPPDDKM VHETSYSAQF KGEASKPTTA 350
    DNKVIDRRRI RSLYSEPFKE PPKVEKPSVQ SSKPKKTSAS HKPTRKAKDK 400
    QAVSGQAAKK KSAEGPSTTK PDDKEQSKEM NNKLAEAKES LAQPVSDSSK 450
    TQGPVATEPD KDQGSVVPGL LKGQGPMVQE PLKKQGSVVP GPPKDLGPMI 500
    PLPVKDQDHT VPEPLKNESP VISAPVKDQG PSVPVPPKNQ SPMVPAKVKD 550
    QGSVVPESLK DQGPRIPEPV KNQAPMVPAP VKDEGPMVSA SVKDQGPMVS 600
    APVKDQGPIV PAPVKGEGPI VPAPVKDEGP MVSAPIKDQD PMVPEHPKDE 650
    SAMATAPIKN QGSMVSEPVK NQGLVVSGPV KDQDVVVPEH AKVHDSAVVA 700
    PVKNQGPVVP ESVKNQDPIL PVLVKDQGPT VLQPPKNQGR IVPEPLKNQV 750
    PIVPVPLKDQ DPLVPVPAKD QGPAVPEPLK TQGPRDPQLP TVSPLPRVMI 800
    PTAPHTEYIE SSP 813
    Length:813
    Mass (Da):86,505
    Last modified:July 22, 2008 - v2
    Checksum:i9680ACAFDB5694D1
    GO
    Isoform 2 (identifier: Q96JE9-2) [UniParc]FASTAAdd to Basket

    Also known as: E-STOP, Early-STOP

    The sequence of this isoform differs from the canonical sequence as follows:
         440-813: Missing.

    Show »
    Length:439
    Mass (Da):47,376
    Checksum:i3FBA4647C7906F89
    GO
    Isoform 3 (identifier: Q96JE9-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-329: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:484
    Mass (Da):51,329
    Checksum:iF49849A9813B336C
    GO

    Sequence cautioni

    The sequence AAH63860.1 differs from that shown. Reason: Erroneous initiation.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti247 – 2471I → M.1 Publication
    Corresponds to variant rs12225010 [ dbSNP | Ensembl ].
    VAR_044542

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 329329Missing in isoform 3. 2 PublicationsVSP_054151Add
    BLAST
    Alternative sequencei440 – 813374Missing in isoform 2. 1 PublicationVSP_034723Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK123340 mRNA. Translation: BAC85586.1.
    AP001922 Genomic DNA. No translation available.
    BC063860 mRNA. Translation: AAH63860.1. Different initiation.
    BC139780 mRNA. Translation: AAI39781.1.
    BC150254 mRNA. Translation: AAI50255.1.
    AB058781 mRNA. Translation: BAB47507.1.
    CCDSiCCDS31641.1. [Q96JE9-1]
    CCDS44686.1. [Q96JE9-2]
    RefSeqiNP_149052.1. NM_033063.1. [Q96JE9-1]
    NP_997460.1. NM_207577.1. [Q96JE9-2]
    UniGeneiHs.585540.

    Genome annotation databases

    EnsembliENST00000304771; ENSP00000307093; ENSG00000171533. [Q96JE9-1]
    ENST00000434603; ENSP00000415108; ENSG00000171533. [Q96JE9-2]
    ENST00000526740; ENSP00000434278; ENSG00000171533. [Q96JE9-3]
    GeneIDi4135.
    KEGGihsa:4135.
    UCSCiuc001owu.3. human. [Q96JE9-1]

    Polymorphism databases

    DMDMi205830862.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK123340 mRNA. Translation: BAC85586.1 .
    AP001922 Genomic DNA. No translation available.
    BC063860 mRNA. Translation: AAH63860.1 . Different initiation.
    BC139780 mRNA. Translation: AAI39781.1 .
    BC150254 mRNA. Translation: AAI50255.1 .
    AB058781 mRNA. Translation: BAB47507.1 .
    CCDSi CCDS31641.1. [Q96JE9-1 ]
    CCDS44686.1. [Q96JE9-2 ]
    RefSeqi NP_149052.1. NM_033063.1. [Q96JE9-1 ]
    NP_997460.1. NM_207577.1. [Q96JE9-2 ]
    UniGenei Hs.585540.

    3D structure databases

    ProteinModelPortali Q96JE9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 110307. 3 interactions.
    IntActi Q96JE9. 1 interaction.
    STRINGi 9606.ENSP00000307093.

    PTM databases

    PhosphoSitei Q96JE9.

    Polymorphism databases

    DMDMi 205830862.

    Proteomic databases

    PaxDbi Q96JE9.
    PRIDEi Q96JE9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000304771 ; ENSP00000307093 ; ENSG00000171533 . [Q96JE9-1 ]
    ENST00000434603 ; ENSP00000415108 ; ENSG00000171533 . [Q96JE9-2 ]
    ENST00000526740 ; ENSP00000434278 ; ENSG00000171533 . [Q96JE9-3 ]
    GeneIDi 4135.
    KEGGi hsa:4135.
    UCSCi uc001owu.3. human. [Q96JE9-1 ]

    Organism-specific databases

    CTDi 4135.
    GeneCardsi GC11M075297.
    H-InvDB HIX0009952.
    HIX0171354.
    HGNCi HGNC:6868. MAP6.
    HPAi CAB015442.
    CAB022600.
    HPA039061.
    HPA039062.
    MIMi 601783. gene.
    neXtProti NX_Q96JE9.
    PharmGKBi PA30614.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG87903.
    HOGENOMi HOG000113479.
    HOVERGENi HBG053112.
    InParanoidi Q96JE9.
    KOi K10432.
    OMAi RKAGPAW.
    OrthoDBi EOG7ZWD1D.
    PhylomeDBi Q96JE9.
    TreeFami TF338320.

    Miscellaneous databases

    GeneWikii MAP6.
    GenomeRNAii 4135.
    NextBioi 16240.
    PROi Q96JE9.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q96JE9.
    Bgeei Q96JE9.
    CleanExi HS_MAP6.
    Genevestigatori Q96JE9.

    Family and domain databases

    InterProi IPR007882. MAP6.
    IPR024963. MAP6/FAM154.
    [Graphical view ]
    PANTHERi PTHR14759. PTHR14759. 1 hit.
    Pfami PF05217. STOP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
      Tissue: Brain.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3), VARIANT MET-247.
      Tissue: PNS.
    4. "Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
      Nagase T., Nakayama M., Nakajima D., Kikuno R., Ohara O.
      DNA Res. 8:85-95(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 91-813 (ISOFORM 1).
      Tissue: Brain.
    5. "Stable tubule only polypeptides (STOP) proteins co-aggregate with spheroid neurofilaments in amyotrophic lateral sclerosis."
      Letournel F., Bocquet A., Dubas F., Barthelaix A., Eyer J.
      J. Neuropathol. Exp. Neurol. 62:1211-1219(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    6. Cited for: TISSUE SPECIFICITY.
    7. "The FTLD risk factor TMEM106B and MAP6 control dendritic trafficking of lysosomes."
      Schwenk B.M., Lang C.M., Hogl S., Tahirovic S., Orozco D., Rentzsch K., Lichtenthaler S.F., Hoogenraad C.C., Capell A., Haass C., Edbauer D.
      EMBO J. 33:450-467(2014) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH TMEM106B.

    Entry informationi

    Entry nameiMAP6_HUMAN
    AccessioniPrimary (citable) accession number: Q96JE9
    Secondary accession number(s): A7E2A1, Q6P3T0, Q6ZWB8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 22, 2008
    Last sequence update: July 22, 2008
    Last modified: October 1, 2014
    This is version 84 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3