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Protein

Microtubule-associated protein 6

Gene

MAP6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in microtubule stabilization in many cell types, including neuronal cells. Specifically has microtubule cold stabilizing activity. Involved in dendrite morphogenesis and maintenance by regulating lysosomal trafficking via its interaction with TMEM106B.1 Publication

GO - Biological processi

  1. dendrite morphogenesis Source: UniProtKB
  2. lysosome localization Source: UniProtKB
  3. microtubule cytoskeleton organization Source: InterPro
  4. transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

Calmodulin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Microtubule-associated protein 6
Short name:
MAP-6
Alternative name(s):
Stable tubule-only polypeptide
Short name:
STOP
Gene namesi
Name:MAP6
Synonyms:KIAA1878
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:6868. MAP6.

Subcellular locationi

Cytoplasmcytoskeleton 1 Publication. Golgi apparatus By similarity
Note: Colocalizes with neurofilament (NF)-rich inclusions in spinal chord and brain neurons of patients with amyotrophic lateral sclerosis (ALS).

GO - Cellular componenti

  1. Golgi apparatus Source: UniProtKB-SubCell
  2. microtubule Source: UniProtKB
  3. perinuclear region of cytoplasm Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Golgi apparatus, Microtubule

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30614.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 813813Microtubule-associated protein 6PRO_0000344044Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi5 – 51S-palmitoyl cysteineBy similarity
Lipidationi10 – 101S-palmitoyl cysteineBy similarity
Lipidationi11 – 111S-palmitoyl cysteineBy similarity
Modified residuei143 – 1431PhosphotyrosineBy similarity

Keywords - PTMi

Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

PaxDbiQ96JE9.
PRIDEiQ96JE9.

PTM databases

PhosphoSiteiQ96JE9.

Expressioni

Tissue specificityi

Expressed in brain (at protein level). Expressed in spinal chord. Isoform 2 expression is up-regulated in the prefrontal cortex (Brodmann's area 46) of patients with schizophrenia (postmortem brain study).2 Publications

Gene expression databases

BgeeiQ96JE9.
CleanExiHS_MAP6.
GenevestigatoriQ96JE9.

Organism-specific databases

HPAiCAB015442.
CAB022600.
HPA039061.
HPA039062.

Interactioni

Subunit structurei

Interacts with calmodulin (via C-terminus); the interaction is dependent on Ca2+ (By similarity). Interacts with TMEM106B.By similarity1 Publication

Protein-protein interaction databases

BioGridi110307. 3 interactions.
IntActiQ96JE9. 1 interaction.
STRINGi9606.ENSP00000307093.

Structurei

3D structure databases

ProteinModelPortaliQ96JE9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni118 – 14124Mn 1Add
BLAST
Regioni126 – 14015Calmodulin-bindingBy similarityAdd
BLAST
Regioni153 – 17624Mn 2Add
BLAST
Regioni162 – 17615Calmodulin-bindingBy similarityAdd
BLAST
Regioni189 – 20315Calmodulin-bindingBy similarityAdd
BLAST
Regioni298 – 32124Mn 3Add
BLAST
Regioni306 – 32015Calmodulin-bindingBy similarityAdd
BLAST
Regioni357 – 37115Calmodulin-bindingBy similarityAdd
BLAST
Regioni384 – 39815Calmodulin-bindingBy similarityAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi43 – 497Poly-Pro
Compositional biasi490 – 804315Pro-richAdd
BLAST

Sequence similaritiesi

Belongs to the STOP family.Curated

Phylogenomic databases

eggNOGiNOG87903.
GeneTreeiENSGT00530000063947.
HOGENOMiHOG000113479.
HOVERGENiHBG053112.
InParanoidiQ96JE9.
KOiK10432.
OMAiPQSQERW.
OrthoDBiEOG7ZWD1D.
PhylomeDBiQ96JE9.
TreeFamiTF338320.

Family and domain databases

InterProiIPR007882. MAP6.
IPR024963. MAP6/FAM154.
[Graphical view]
PANTHERiPTHR14759. PTHR14759. 1 hit.
PfamiPF05217. STOP. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96JE9-1) [UniParc]FASTAAdd to basket

Also known as: N-STOP, Neuronal-STOP

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAWPCITRAC CIARFWNQLD KADIAVPLVF TKYSEATEHP GAPPQPPPPQ
60 70 80 90 100
QQAQPALAPP SARAVAIETQ PAQGELDAVA RATGPAPGPT GEREPAAGPG
110 120 130 140 150
RSGPGPGLGS GSTSGPADSV MRQDYRAWKV QRPEPSCRPR SEYQPSDAPF
160 170 180 190 200
ERETQYQKDF RAWPLPRRGD HPWIPKPVQI SAASQASAPI LGAPKRRPQS
210 220 230 240 250
QERWPVQAAA EAREQEAAPG GAGGLAAGKA SGADERDTRR KAGPAWIVRR
260 270 280 290 300
AEGLGHEQTP LPAAQAQVQA TGPEAGRGRA AADALNRQIR EEVASAVSSS
310 320 330 340 350
YRNEFRAWTD IKPVKPIKAK PQYKPPDDKM VHETSYSAQF KGEASKPTTA
360 370 380 390 400
DNKVIDRRRI RSLYSEPFKE PPKVEKPSVQ SSKPKKTSAS HKPTRKAKDK
410 420 430 440 450
QAVSGQAAKK KSAEGPSTTK PDDKEQSKEM NNKLAEAKES LAQPVSDSSK
460 470 480 490 500
TQGPVATEPD KDQGSVVPGL LKGQGPMVQE PLKKQGSVVP GPPKDLGPMI
510 520 530 540 550
PLPVKDQDHT VPEPLKNESP VISAPVKDQG PSVPVPPKNQ SPMVPAKVKD
560 570 580 590 600
QGSVVPESLK DQGPRIPEPV KNQAPMVPAP VKDEGPMVSA SVKDQGPMVS
610 620 630 640 650
APVKDQGPIV PAPVKGEGPI VPAPVKDEGP MVSAPIKDQD PMVPEHPKDE
660 670 680 690 700
SAMATAPIKN QGSMVSEPVK NQGLVVSGPV KDQDVVVPEH AKVHDSAVVA
710 720 730 740 750
PVKNQGPVVP ESVKNQDPIL PVLVKDQGPT VLQPPKNQGR IVPEPLKNQV
760 770 780 790 800
PIVPVPLKDQ DPLVPVPAKD QGPAVPEPLK TQGPRDPQLP TVSPLPRVMI
810
PTAPHTEYIE SSP
Length:813
Mass (Da):86,505
Last modified:July 22, 2008 - v2
Checksum:i9680ACAFDB5694D1
GO
Isoform 2 (identifier: Q96JE9-2) [UniParc]FASTAAdd to basket

Also known as: E-STOP, Early-STOP

The sequence of this isoform differs from the canonical sequence as follows:
     440-813: Missing.

Show »
Length:439
Mass (Da):47,376
Checksum:i3FBA4647C7906F89
GO
Isoform 3 (identifier: Q96JE9-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-329: Missing.

Note: No experimental confirmation available.

Show »
Length:484
Mass (Da):51,329
Checksum:iF49849A9813B336C
GO

Sequence cautioni

The sequence AAH63860.1 differs from that shown. Reason: Erroneous initiation. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti247 – 2471I → M.1 Publication
Corresponds to variant rs12225010 [ dbSNP | Ensembl ].
VAR_044542

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 329329Missing in isoform 3. 2 PublicationsVSP_054151Add
BLAST
Alternative sequencei440 – 813374Missing in isoform 2. 1 PublicationVSP_034723Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK123340 mRNA. Translation: BAC85586.1.
AP001922 Genomic DNA. No translation available.
BC063860 mRNA. Translation: AAH63860.1. Different initiation.
BC139780 mRNA. Translation: AAI39781.1.
BC150254 mRNA. Translation: AAI50255.1.
AB058781 mRNA. Translation: BAB47507.1.
CCDSiCCDS31641.1. [Q96JE9-1]
CCDS44686.1. [Q96JE9-2]
RefSeqiNP_149052.1. NM_033063.1. [Q96JE9-1]
NP_997460.1. NM_207577.1. [Q96JE9-2]
UniGeneiHs.585540.

Genome annotation databases

EnsembliENST00000304771; ENSP00000307093; ENSG00000171533. [Q96JE9-1]
ENST00000434603; ENSP00000415108; ENSG00000171533. [Q96JE9-2]
ENST00000526740; ENSP00000434278; ENSG00000171533. [Q96JE9-3]
ENST00000614044; ENSP00000484920; ENSG00000171533. [Q96JE9-3]
GeneIDi4135.
KEGGihsa:4135.
UCSCiuc001owu.3. human. [Q96JE9-1]

Polymorphism databases

DMDMi205830862.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK123340 mRNA. Translation: BAC85586.1.
AP001922 Genomic DNA. No translation available.
BC063860 mRNA. Translation: AAH63860.1. Different initiation.
BC139780 mRNA. Translation: AAI39781.1.
BC150254 mRNA. Translation: AAI50255.1.
AB058781 mRNA. Translation: BAB47507.1.
CCDSiCCDS31641.1. [Q96JE9-1]
CCDS44686.1. [Q96JE9-2]
RefSeqiNP_149052.1. NM_033063.1. [Q96JE9-1]
NP_997460.1. NM_207577.1. [Q96JE9-2]
UniGeneiHs.585540.

3D structure databases

ProteinModelPortaliQ96JE9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110307. 3 interactions.
IntActiQ96JE9. 1 interaction.
STRINGi9606.ENSP00000307093.

PTM databases

PhosphoSiteiQ96JE9.

Polymorphism databases

DMDMi205830862.

Proteomic databases

PaxDbiQ96JE9.
PRIDEiQ96JE9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000304771; ENSP00000307093; ENSG00000171533. [Q96JE9-1]
ENST00000434603; ENSP00000415108; ENSG00000171533. [Q96JE9-2]
ENST00000526740; ENSP00000434278; ENSG00000171533. [Q96JE9-3]
ENST00000614044; ENSP00000484920; ENSG00000171533. [Q96JE9-3]
GeneIDi4135.
KEGGihsa:4135.
UCSCiuc001owu.3. human. [Q96JE9-1]

Organism-specific databases

CTDi4135.
GeneCardsiGC11M075297.
H-InvDBHIX0009952.
HIX0171354.
HGNCiHGNC:6868. MAP6.
HPAiCAB015442.
CAB022600.
HPA039061.
HPA039062.
MIMi601783. gene.
neXtProtiNX_Q96JE9.
PharmGKBiPA30614.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG87903.
GeneTreeiENSGT00530000063947.
HOGENOMiHOG000113479.
HOVERGENiHBG053112.
InParanoidiQ96JE9.
KOiK10432.
OMAiPQSQERW.
OrthoDBiEOG7ZWD1D.
PhylomeDBiQ96JE9.
TreeFamiTF338320.

Miscellaneous databases

GeneWikiiMAP6.
GenomeRNAii4135.
NextBioi16240.
PROiQ96JE9.
SOURCEiSearch...

Gene expression databases

BgeeiQ96JE9.
CleanExiHS_MAP6.
GenevestigatoriQ96JE9.

Family and domain databases

InterProiIPR007882. MAP6.
IPR024963. MAP6/FAM154.
[Graphical view]
PANTHERiPTHR14759. PTHR14759. 1 hit.
PfamiPF05217. STOP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Brain.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3), VARIANT MET-247.
    Tissue: PNS.
  4. "Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Nakayama M., Nakajima D., Kikuno R., Ohara O.
    DNA Res. 8:85-95(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 91-813 (ISOFORM 1).
    Tissue: Brain.
  5. "Stable tubule only polypeptides (STOP) proteins co-aggregate with spheroid neurofilaments in amyotrophic lateral sclerosis."
    Letournel F., Bocquet A., Dubas F., Barthelaix A., Eyer J.
    J. Neuropathol. Exp. Neurol. 62:1211-1219(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  6. Cited for: TISSUE SPECIFICITY.
  7. "The FTLD risk factor TMEM106B and MAP6 control dendritic trafficking of lysosomes."
    Schwenk B.M., Lang C.M., Hogl S., Tahirovic S., Orozco D., Rentzsch K., Lichtenthaler S.F., Hoogenraad C.C., Capell A., Haass C., Edbauer D.
    EMBO J. 33:450-467(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH TMEM106B.

Entry informationi

Entry nameiMAP6_HUMAN
AccessioniPrimary (citable) accession number: Q96JE9
Secondary accession number(s): A7E2A1, Q6P3T0, Q6ZWB8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: July 22, 2008
Last modified: March 4, 2015
This is version 87 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.